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Conserved domains on  [gi|42822864|ref|NP_976322|]
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ribonuclease inhibitor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116 238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                ..
gi 42822864 324 SF 325
Cdd:cd00116 318 SF 319
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 42822864 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238 338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116 238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                ..
gi 42822864 324 SF 325
Cdd:cd00116 318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 42822864 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238 338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238 182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238 262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238 340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                       250       260
                ....*....|....*....|
gi 42822864 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238 391 QGAEALIDALQT--NRLHTL 408
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 42822864     6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 42822864    397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 42822864    283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116  80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116 238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                ..
gi 42822864 324 SF 325
Cdd:cd00116 318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 42822864 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238 338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238 182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238 262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238 340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                       250       260
                ....*....|....*....|
gi 42822864 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238 391 QGAEALIDALQT--NRLHTL 408
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 114-308 7.70e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 82.53  E-value: 7.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 114 TLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 194 LKdSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHpSSRLRTLWIWECGITAKGC 273
Cdd:COG5238 260 LK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                       170       180       190
                ....*....|....*....|....*....|....*
gi 42822864 274 GDLCRVLRAKESLKELSLAGNELGDEGARLLCETL 308
Cdd:COG5238 338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 147-450 1.12e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 147 LQLEYCSLSaasCEPLASVLRAKPDFKELTV--SNNDINEAGVRVLCQGLKDSPcQLEALKLESCGVTSDNCRDLCGIVA 224
Cdd:COG5238 158 LLGLAARLG---LLAAISMAKALQNNSVETVylGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALK 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLL 304
Cdd:COG5238 234 GNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIAL 312

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864 305 CETLlEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQglgqpgsvlrvlwladcdvsd 384
Cdd:COG5238 313 AEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK--------------------- 370

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42822864 385 sscsslaatLLANH-SLRELDLSNNCLGDAGILQLVESVRqpGCLLEQLVLYDIYWSEEMEDRLQAL 450
Cdd:COG5238 371 ---------YLEGNtTLRELNLGKNNIGKQGAEALIDALQ--TNRLHTLILDGNLIGAEAQQRLEQL 426
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-195 3.45e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.89  E-value: 3.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   5 IQSLDIQCEELSDARWAELLPLLQ-QCQVVRLDDCG--LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKnNTTVETLYLSGnqIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEP 161
Cdd:COG5238 318 GNK-TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEA 395

                       170       180       190
                ....*....|....*....|....*....|....
gi 42822864 162 LASVLRaKPDFKELTVSNNDINEAGVRVLCQGLK 195
Cdd:COG5238 396 LIDALQ-TNRLHTLILDGNLIGAEAQQRLEQLLE 428
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 42822864     6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-182 6.10e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 6.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864   4 DIQSLDIQCEELSDarWAELLPLLQQCQVVRLDDCGLTearckDISSALRVNPALAELNLRSNELGDVGVHcvLQGLQtp 83
Cdd:COG4886 114 NLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLT-- 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42822864  84 scKIQKLSLQNCCLTgagcgVLSSTLRTLPTLQELHLSDNLLGDAGLQLlceglldPQC-RLEKLQLEYCSLSAascepl 162
Cdd:COG4886 183 --NLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTDLPEPL-------ANLtNLETLDLSNNQLTD------ 242

                       170       180
                ....*....|....*....|
gi 42822864 163 ASVLRAKPDFKELTVSNNDI 182
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQL 262
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 42822864    397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 42822864    283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
112-139 1.02e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|....*...
gi 42822864    112 LPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
340-367 3.92e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 3.92e-03
                           10        20
                   ....*....|....*....|....*...
gi 42822864    340 NRFLLELQISNNRLEDAGVRELCQGLGQ 367
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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