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Conserved domains on  [gi|42476105|ref|NP_963886|]
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neuronal membrane glycoprotein M6-a isoform 3 [Homo sapiens]

Protein Classification

myelin proteolipid family protein( domain architecture ID 10472648)

myelin proteolipid family protein similar to human myelin proteolipid protein (PLP) that plays an important role in the formation or maintenance of the multilamellar structure of myelin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
4-236 3.71e-101

Myelin proteolipid protein (PLP or lipophilin);


:

Pssm-ID: 460144  Cd Length: 231  Bit Score: 294.59  E-value: 3.71e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105     4 FECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFemARTAGDTLDVFTMIDIFKYVIYGIAAAFFV 83
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVF--HRNYQDYELLATWIDAFQYVIYGIAAFFFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105    84 YGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLC 163
Cdd:pfam01275  79 LGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTNQLC 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42476105   164 LDLRQFGIVTIGE-EKKICTVSEnFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACR 236
Cdd:pfam01275 159 IDFRQFGFLPWNAtPGKVCGMTE-LKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
4-236 3.71e-101

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 294.59  E-value: 3.71e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105     4 FECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFemARTAGDTLDVFTMIDIFKYVIYGIAAAFFV 83
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVF--HRNYQDYELLATWIDAFQYVIYGIAAFFFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105    84 YGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLC 163
Cdd:pfam01275  79 LGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTNQLC 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42476105   164 LDLRQFGIVTIGE-EKKICTVSEnFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACR 236
Cdd:pfam01275 159 IDFRQFGFLPWNAtPGKVCGMTE-LKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
146-201 5.41e-18

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 75.60  E-value: 5.41e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42476105    146 NLWTICRNTTLVEGA-----NLCLDLRQFGIVTIGE-EKKICTVseNFLRMCESTELNMTFH 201
Cdd:smart00002   1 NTWTTCQSITFPEKTttsigTLCVDARQYGILPWNAfPGKVCGS--NLLSICKTSEFQMTFH 60
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
4-236 3.71e-101

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 294.59  E-value: 3.71e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105     4 FECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFemARTAGDTLDVFTMIDIFKYVIYGIAAAFFV 83
Cdd:pfam01275   1 YDCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVF--HRNYQDYELLATWIDAFQYVIYGIAAFFFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476105    84 YGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLC 163
Cdd:pfam01275  79 LGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAVFMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLSTNQLC 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42476105   164 LDLRQFGIVTIGE-EKKICTVSEnFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACR 236
Cdd:pfam01275 159 IDFRQFGFLPWNAtPGKVCGMTE-LKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
146-201 5.41e-18

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 75.60  E-value: 5.41e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42476105    146 NLWTICRNTTLVEGA-----NLCLDLRQFGIVTIGE-EKKICTVseNFLRMCESTELNMTFH 201
Cdd:smart00002   1 NTWTTCQSITFPEKTttsigTLCVDARQYGILPWNAfPGKVCGS--NLLSICKTSEFQMTFH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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