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Conserved domains on  [gi|238550175|ref|NP_958745|]
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EARP and GARP complex-interacting protein 1 isoform a [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-373 1.17e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 135 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 212
Cdd:cd00200   10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 213 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 292
Cdd:cd00200   79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 293 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 352
Cdd:cd00200  155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260
                 ....*....|....*....|.
gi 238550175 353 DWaSADPWLFASLSYDGRLVI 373
Cdd:cd00200  226 AF-SPDGYLLASGSEDGTIRV 245
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-373 1.17e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 135 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 212
Cdd:cd00200   10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 213 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 292
Cdd:cd00200   79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 293 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 352
Cdd:cd00200  155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260
                 ....*....|....*....|.
gi 238550175 353 DWaSADPWLFASLSYDGRLVI 373
Cdd:cd00200  226 AF-SPDGYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
59-377 3.84e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175  59 VLLHQAGEIWHISASPADKGVLATCYNKTtdsrvqacAAVWrmpkelesgshespdDPASTAQTLELLCHldnsaQGNVA 138
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGT--------VRLW---------------DLATGKLLRTLTGH-----SGAVT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 139 CVVWEPmgDGKKVISL-ADSHILLWDLQpsSSQAVlassATLEGRGQLkFTAGRWSPhhNCTQVATAS-DTTLRGWDTRS 216
Cdd:COG2319  167 SVAFSP--DGKLLASGsDDGTVRLWDLA--TGKLL----RTLTGHTGA-VRSVAFSP--DGKLLASGSaDGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 217 MSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLTGSSDS 295
Cdd:COG2319  236 GKLLRTLT-GHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAF--SPDgKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 296 RVIL---------------SNMV-SISSEPFGHLV----DDG-----DISDPEEhhaekskeplqdnvIATYEEHEDSVY 350
Cdd:COG2319  311 TVRLwdlatgkllrtltghTGAVrSVAFSPDGKTLasgsDDGtvrlwDLATGEL--------------LRTLTGHTGAVT 376

                        330       340
                 ....*....|....*....|....*..
gi 238550175 351 AVDWASADPWLfASLSYDGRLVINRVP 377
Cdd:COG2319  377 SVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 238550175   225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 7.74e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.74e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 238550175  225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 204-260 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238550175 204 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 260
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-373 1.17e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 135 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 212
Cdd:cd00200   10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 213 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 292
Cdd:cd00200   79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 293 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 352
Cdd:cd00200  155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260
                 ....*....|....*....|.
gi 238550175 353 DWaSADPWLFASLSYDGRLVI 373
Cdd:cd00200  226 AF-SPDGYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
59-377 3.84e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175  59 VLLHQAGEIWHISASPADKGVLATCYNKTtdsrvqacAAVWrmpkelesgshespdDPASTAQTLELLCHldnsaQGNVA 138
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGT--------VRLW---------------DLATGKLLRTLTGH-----SGAVT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 139 CVVWEPmgDGKKVISL-ADSHILLWDLQpsSSQAVlassATLEGRGQLkFTAGRWSPhhNCTQVATAS-DTTLRGWDTRS 216
Cdd:COG2319  167 SVAFSP--DGKLLASGsDDGTVRLWDLA--TGKLL----RTLTGHTGA-VRSVAFSP--DGKLLASGSaDGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 217 MSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLTGSSDS 295
Cdd:COG2319  236 GKLLRTLT-GHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAF--SPDgKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 296 RVIL---------------SNMV-SISSEPFGHLV----DDG-----DISDPEEhhaekskeplqdnvIATYEEHEDSVY 350
Cdd:COG2319  311 TVRLwdlatgkllrtltghTGAVrSVAFSPDGKTLasgsDDGtvrlwDLATGEL--------------LRTLTGHTGAVT 376

                        330       340
                 ....*....|....*....|....*..
gi 238550175 351 AVDWASADPWLfASLSYDGRLVINRVP 377
Cdd:COG2319  377 SVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-299 2.84e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175  39 YDNQIHIIDFddENNIINKNVLLHqAGEIWHISASPADKGVLATCYNKTT---DSRVQACAAVWRMPKELESGSHESPDD 115
Cdd:cd00200   29 GDGTIKVWDL--ETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIrlwDLETGECVRTLTGHTSYVSSVAFSPDG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 116 P----ASTAQTL------------ELLCHLDNsaqgnVACVVWEPmgdGKKVI--SLADSHILLWDLQPSSSQAvlassa 177
Cdd:cd00200  106 RilssSSRDKTIkvwdvetgkcltTLRGHTDW-----VNSVAFSP---DGTFVasSSQDGTIKLWDLRTGKCVA------ 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 178 TLEG-RGQLKFTAgrWSPhhNCTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKqYYLASCGDDCKVKF 255
Cdd:cd00200  172 TLTGhTGEVNSVA--FSP--DGEKLLSSSsDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDG-YLLASGSEDGTIRV 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 238550175 256 WDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:cd00200  246 WDLRT-GECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
147-373 2.31e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 147 DGKKVISLA-DSHILLWDLQPSSSQAvlassaTLEGRGQlKFTAGRWSPhhNCTQVATAS-DTTLRGWDTRSMSQIYCIE 224
Cdd:COG2319   89 DGRLLASASaDGTVRLWDLATGLLLR------TLTGHTG-AVRSVAFSP--DGKTLASGSaDGTVRLWDLATGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 225 nAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLTGSSDSRVILSNmv 303
Cdd:COG2319  160 -GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAF--SPDgKLLASGSADGTVRLWD-- 232

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 304 sissepfghlVDDGDisdpeehhaekskeplqdnVIATYEEHEDSVYAVDWaSADPWLFASLSYDGRLVI 373
Cdd:COG2319  233 ----------LATGK-------------------LLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-373 3.24e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 227 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVILSnmvsis 306
Cdd:cd00200    8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLW------ 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238550175 307 sepfghlvddgDISDPEEHHaekskeplqdnviaTYEEHEDSVYAVDWASADPWLFASlSYDGRLVI 373
Cdd:cd00200   79 -----------DLETGECVR--------------TLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-257 1.33e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 134 QGNVACVVWEPmgDGKKVISLA-DSHILLWDLQPSssqavlASSATLEGRGQlKFTAGRWSPHHNcTQVATASDTTLRGW 212
Cdd:cd00200  177 TGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTG------KCLGTLRGHEN-GVNSVAFSPDGY-LLASGSEDGTIRVW 246

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 238550175 213 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:cd00200  247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-260 3.09e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175  39 YDNQIHIIDFDDENNIInknVLLHQAGEIWHISASPaDKGVLATCynkTTDSRVQacaaVWRmpkelesgshespddpAS 118
Cdd:COG2319  224 ADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSP-DGRLLASG---SADGTVR----LWD----------------LA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550175 119 TAQTLELLCHLDNSaqgnVACVVWEPmgDGKKVISL-ADSHILLWDLqpsSSQAVLAssaTLEGRGQlKFTAGRWSPhhN 197
Cdd:COG2319  277 TGELLRTLTGHSGG----VNSVAFSP--DGKLLASGsDDGTVRLWDL---ATGKLLR---TLTGHTG-AVRSVAFSP--D 341

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238550175 198 CTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRN 260
Cdd:COG2319  342 GKTLASGSdDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 238550175   225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 7.74e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.74e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 238550175  225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-299 1.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 238550175   263 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKL 38
PTZ00420 PTZ00420
coronin; Provisional
 204-260 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238550175 204 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 260
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
263-299 2.57e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 238550175  263 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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