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Conserved domains on  [gi|38570135|ref|NP_942089|]
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mitogen-activated protein kinase kinase kinase kinase 5 [Homo sapiens]

Protein Classification

mitogen-activated protein kinase kinase kinase kinase 5( domain architecture ID 10159732)

mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
10-277 0e+00

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 594.70  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06646   1 DILRRNPQHDYELIQRVGSGTYGDVYKARNLHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06646  81 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Cdd:cd06646 161 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 240
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06646 241 FHNFVKISLTKNPKKRPTAERLLTHLFV 268
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
511-826 5.36e-102

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 318.14  E-value: 5.36e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    511 CATSWIHPDTKDQ-YIIFGTEDGIYTLNLNELHeATMEQLFPRK---CTWLYVINNTLMSLSeGKTFQLYSHNLIALFEH 586
Cdd:smart00036   1 NTAKWNHPITCDGkWLLVGTEEGLYVLNISDQP-GTLEKLIGRRsvtQIWVLEENNVLLMIS-GKKPQLYSHPLSALVEK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    587 AkkpglaahiqTHRFPDRILPRKFALTtKIPDTKGCHKCCIVRNPYtgHKYLCGALQSGIVLLQWYEPMQKFMLIKHF-D 665
Cdd:smart00036  79 K----------EALGSARLVIRKNVLT-KIPDVKGCHLCAVVNGKR--SLFLCVALQSSVVLLQWYNPLKKFKLFKSKfL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    666 FPLPSPLNVFEMLVIPEQEYPMVCVAISKGteSNQVVQFE--TINLNSASSWFTEIGAGSqqlDSIHVTQLERDTVLVCL 743
Cdd:smart00036 146 FPLISPVPVFVELVSSSFERPGICIGSDKG--GGDVVQFHesLVSKEDLSLPFLSEETSL---KPISVVQVPRDEVLLCY 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    744 DKFVKIVNLQGKlksSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISD-ETRVFRLLG-SDRVVV 821
Cdd:smart00036 221 DEFGVFVNLYGK---RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADrETRKIRLLGsSDRKIL 297

                   ....*
gi 38570135    822 LESRP 826
Cdd:smart00036 298 LSSSP 302
 
Name Accession Description Interval E-value
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
10-277 0e+00

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 594.70  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06646   1 DILRRNPQHDYELIQRVGSGTYGDVYKARNLHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06646  81 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Cdd:cd06646 161 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 240
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06646 241 FHNFVKISLTKNPKKRPTAERLLTHLFV 268
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
511-826 5.36e-102

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 318.14  E-value: 5.36e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    511 CATSWIHPDTKDQ-YIIFGTEDGIYTLNLNELHeATMEQLFPRK---CTWLYVINNTLMSLSeGKTFQLYSHNLIALFEH 586
Cdd:smart00036   1 NTAKWNHPITCDGkWLLVGTEEGLYVLNISDQP-GTLEKLIGRRsvtQIWVLEENNVLLMIS-GKKPQLYSHPLSALVEK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    587 AkkpglaahiqTHRFPDRILPRKFALTtKIPDTKGCHKCCIVRNPYtgHKYLCGALQSGIVLLQWYEPMQKFMLIKHF-D 665
Cdd:smart00036  79 K----------EALGSARLVIRKNVLT-KIPDVKGCHLCAVVNGKR--SLFLCVALQSSVVLLQWYNPLKKFKLFKSKfL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    666 FPLPSPLNVFEMLVIPEQEYPMVCVAISKGteSNQVVQFE--TINLNSASSWFTEIGAGSqqlDSIHVTQLERDTVLVCL 743
Cdd:smart00036 146 FPLISPVPVFVELVSSSFERPGICIGSDKG--GGDVVQFHesLVSKEDLSLPFLSEETSL---KPISVVQVPRDEVLLCY 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    744 DKFVKIVNLQGKlksSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISD-ETRVFRLLG-SDRVVV 821
Cdd:smart00036 221 DEFGVFVNLYGK---RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADrETRKIRLLGsSDRKIL 297

                   ....*
gi 38570135    822 LESRP 826
Cdd:smart00036 298 LSSSP 302
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
20-277 1.45e-86

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 275.56  E-value: 1.45e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDrERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRKSFIGT 178
Cdd:smart00220  81 GGDLFDLLKKRGRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPG-EKLTTFVGT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF-LMSKSNFQPPklKDKTKWSSTFHNFVKIA 257
Cdd:smart00220 160 PEYMAPEVL---LGKGYGKAVDIWSLGVILYELLTGKPPFPGDDQLLELFkKIGKPKPPFP--PPEWDISPEAKDLIRKL 234
                          250       260
                   ....*....|....*....|
gi 38570135    258 LTKNPKKRPTAERLLTHTFV 277
Cdd:smart00220 235 LVKDPEKRLTAEEALQHPFF 254
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
522-815 4.05e-51

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 180.13  E-value: 4.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   522 DQYIIFGTEDGIYTLNLNelHEATMEQLF-PRKCTWLYVIN--NTLMSLSeGKTFQLYSHNLIALFehakkpglaahiqt 598
Cdd:pfam00780   2 GQNLLLGTEEGLYVLNRS--GPREPVRIIdKKRVTQLAVLEefNLLLLLS-GKDKRLYVYPLSALD-------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   599 hrfPDRILPRKFALTTKIPDTKGCHKCCIVRNpyTGHKYLCGALQSGIVLLQWYEPMQ-KFMLIKHFDFPLPSPlnVFEM 677
Cdd:pfam00780  65 ---SREENDRKDAAKNKLPETKGCHFFKVGRH--SNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPV--SIEL 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   678 LVipeqeyPMVCVAISKGtesnqvvqFETINLNSASSW----FTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQ 753
Cdd:pfam00780 138 LK------SKLCVGCAKG--------FEIVSLDSKATEslltSLLFANRQENLKPLAVVRLDRSEFLLCYNEFGVYVNLQ 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135   754 GKLKSSkklaSELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLG 815
Cdd:pfam00780 204 GRRSRP----WEIEWEGAPEAVAYLYPYLLAFHDNFIEIRDVETGELVQEIAGRKIRFLNSG 261
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
20-272 3.13e-49

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 181.36  E-value: 3.13e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLI---QQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:COG0515   9 YRILRLLGRGGMGVVYLARDLRLGRPVALKVLRPELAADPEARerfRREARALARLNHPNIVRVYDVGEEDGRPYLVMEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AKITATIAKRKSF 175
Cdd:COG0515  89 VEGESLADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIArALGGATLTQTGTV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVK 255
Cdd:COG0515 169 VGTPGYMAPEQAR---GEPVDPRSDVYSLGVTLYELLTGRPP-FDGDSPAELLRAHLREPPPPPSELRPDLPPALDAIVL 244
                       250
                ....*....|....*...
gi 38570135 256 IALTKNPKKRP-TAERLL 272
Cdd:COG0515 245 RALAKDPEERYqSAAELA 262
Pkinase pfam00069
Protein kinase domain;
20-277 7.69e-47

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 166.27  E-value: 7.69e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD--FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKkkDKNILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHtkgkmhrdikganilltdhgdvkladfgvaakitatiaKRKSFIG 177
Cdd:pfam00069  81 EGGSLFDLLSEKGAFSEREAKFIMKQILEGLESGS--------------------------------------SLTTFVG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   178 TPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTkWSSTFHNFVKIA 257
Cdd:pfam00069 123 TPWYMAPEVL---GGNPYGPKVDVWSLGCILYELLTGKPP-FPGINGNEIYELIIDQPYAFPELPSN-LSEEAKDLLKKL 197
                         250       260
                  ....*....|....*....|
gi 38570135   258 LTKNPKKRPTAERLLTHTFV 277
Cdd:pfam00069 198 LKKDPSKRLTATQALQHPWF 217
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
16-284 1.44e-37

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 144.20  E-value: 1.44e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:PLN00034  72 SLSELERVNRIGSGAGGTVYKVIHRPTGRLYALKVIYGNHEDTVRRqICREIEILRDVNHPNVVKCHDMFDHNGEIQVLL 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   95 EYCGGGSLQDiYHVTgplSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:PLN00034 152 EFMDGGSLEG-THIA---DEQFLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNS 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  175 FIGTPYWMAPEVAAVEKN-GGYNQLC-DIWAVGITAIE--LGELQPPMF---DLHPMRALFLMSKSNFQPPKLkdktkwS 247
Cdd:PLN00034 228 SVGTIAYMSPERINTDLNhGAYDGYAgDIWSLGVSILEfyLGRFPFGVGrqgDWASLMCAICMSQPPEAPATA------S 301
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 38570135  248 STFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSR 284
Cdd:PLN00034 302 REFRHFISCCLQREPAKRWSAMQLLQHPFILRAQPGQ 338
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
20-220 1.56e-22

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 102.57  E-value: 1.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfsliqqEIFMVK---ECK------HCNIVAYF-----GSYL 85
Cdd:NF033483   9 YEIGERIGRGGMAEVYLAKDTRLDRDVAVKVLRPDLARD------PEFVARfrrEAQsaaslsHPNIVSVYdvgedGGIP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   86 sreklWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AK 164
Cdd:NF033483  83 -----YIVMEYVDGRTLKDYIREHGPLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIArAL 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135  165 ITATIAKRKSFIGTPYWMAPEVAAveknGGY--NQlCDIWAVGITaieLGEL---QPPmFD 220
Cdd:NF033483 158 SSTTMTQTNSVLGTVHYLSPEQAR----GGTvdAR-SDIYSLGIV---LYEMltgRPP-FD 209
 
Name Accession Description Interval E-value
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
10-277 0e+00

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 594.70  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06646   1 DILRRNPQHDYELIQRVGSGTYGDVYKARNLHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06646  81 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Cdd:cd06646 161 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 240
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06646 241 FHNFVKISLTKNPKKRPTAERLLTHLFV 268
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
19-277 0e+00

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 581.19  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd06613   1 DYELIQRIGSGTYGDVYKARNIATGELAAVKVIKLEPGDDFEIIQQEISMLKECRHPNIVAYFGSYLRRDKLWIVMEYCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGT 178
Cdd:cd06613  81 GGSLQDIYQVTGPLSELQIAYVCRETLKGLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQLTATIAKRKSFIGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIAL 258
Cdd:cd06613 161 PYWMAPEVAAVERKGGYDGKCDIWALGITAIELAELQPPMFDLHPMRALFLIPKSNFDPPKLKDKEKWSPDFHDFIKKCL 240
                       250
                ....*....|....*....
gi 38570135 259 TKNPKKRPTAERLLTHTFV 277
Cdd:cd06613 241 TKNPKKRPTATKLLQHPFV 259
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
10-279 6.89e-178

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 512.67  E-value: 6.89e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  10 DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06645   3 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHSNIVAYFGSYLRRDK 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06645  83 LWICMEFCGGGSLQDIYHVTGPLSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Cdd:cd06645 163 AKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 242
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06645 243 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 272
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
19-277 9.94e-123

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 369.99  E-value: 9.94e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd05122   1 LFEILEKIGKGGFGVVYKARHKKTGQIVAIKKINLESKEKKESILNEIAILKKCKHPNIVKYYGSYLKKDELWIVMEFCS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVT-GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAkRKSFIG 177
Cdd:cd05122  81 GGSLKDLLKNTnKTLTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSAQLSDGKT-RNTFVG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIA 257
Cdd:cd05122 160 TPYWMAPEVI---QGKPYGFKADIWSLGITAIEMAEGKPPYSELPPMKALFLIATNG--PPGLRNPKKWSKEFKDFLKKC 234
                       250       260
                ....*....|....*....|
gi 38570135 258 LTKNPKKRPTAERLLTHTFV 277
Cdd:cd05122 235 LQKDPEKRPTAEQLLKHPFI 254
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
16-277 2.45e-116

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 353.49  E-value: 2.45e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgdDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd06612   1 PEEVFDILEKLGEGSYGSVYKAIHKETGQVVAIKVVPVEE--DLQEIIKEISILKQCDSPYIVKYYGSYFKNTDLWIVME 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06612  79 YCGAGSVSDIMKITNkTLTEEEIAAILYQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKLADFGVSGQLTDTMAKRNT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMskSNFQPPKLKDKTKWSSTFHNFV 254
Cdd:cd06612 159 VIGTPFWMAPEV--IQEI-GYNNKADIWSLGITAIEMAEGKPPYSDIHPMRAIFMI--PNKPPPTLSDPEKWSPEFNDFV 233
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06612 234 KKCLVKDPEERPSAIQLLQHPFI 256
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
18-277 1.71e-115

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 352.32  E-value: 1.71e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06609   1 ELFTLLERIGKGSFGEVYKGIDKRTNQVVAIKVIDLEEAeDEIEDIQQEIQFLSQCDSPYITKYYGSFLKGSKLWIIMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd06609  81 CGGGSVLDLLK-PGPLDETYIAFILREVLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLADFGVSGQLTSTMSKRNTFV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKtKWSSTFHNFVKI 256
Cdd:cd06609 160 GTPFWMAPEVI---KQSGYDEKADIWSLGITAIELAKGEPPLSDLHPMRVLFLIPKNN--PPSLEGN-KFSKPFKDFVEL 233
                       250       260
                ....*....|....*....|.
gi 38570135 257 ALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06609 234 CLNKDPKERPSAKELLKHKFI 254
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
14-277 5.98e-110

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 337.74  E-value: 5.98e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLSR----- 87
Cdd:cd06608   2 PDPAGIFELVEVIGEGTYGKVYKARHKKTGQLAAIKIMDIIE-DEEEEIKLEINILRKfSNHPNIATFYGAFIKKdppgg 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 -EKLWICMEYCGGGSLQD----IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd06608  81 dDQLWLVMEYCGGGSVTDlvkgLRKKGKRLKEEWIAYILRETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFGVS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKL 240
Cdd:cd06608 161 AQLDSTLGRRNTFIGTPYWMAPEVIACDQQpdASYDARCDVWSLGITAIELADGKPPLCDMHPMRALFKIPRN--PPPTL 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06608 239 KSPEKWSKEFNDFISECLIKNYEQRPFTEELLEHPFI 275
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
20-278 3.84e-102

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 316.46  E-value: 3.84e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd06614   2 YKNLEKIGEGASGEVYKATDRATGKEVAIKKMRLR-KQNKELIINEILIMKECKHPNIVDYYDSYLVGDELWVVMEYMDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGT 178
Cdd:cd06614  81 GSLTDiITQNPVRMNESQIAYVCREVLQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLTKEKSKRNSVVGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIAL 258
Cdd:cd06614 161 PYWMAPEVI---KRKDYGPKVDIWSLGIMCIEMAEGEPPYLEEPPLRALFLITTKG--IPPLKNPEKWSPEFKDFLNKCL 235
                       250       260
                ....*....|....*....|
gi 38570135 259 TKNPKKRPTAERLLTHTFVA 278
Cdd:cd06614 236 VKDPEKRPSAEELLQHPFLK 255
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
511-826 5.36e-102

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 318.14  E-value: 5.36e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    511 CATSWIHPDTKDQ-YIIFGTEDGIYTLNLNELHeATMEQLFPRK---CTWLYVINNTLMSLSeGKTFQLYSHNLIALFEH 586
Cdd:smart00036   1 NTAKWNHPITCDGkWLLVGTEEGLYVLNISDQP-GTLEKLIGRRsvtQIWVLEENNVLLMIS-GKKPQLYSHPLSALVEK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    587 AkkpglaahiqTHRFPDRILPRKFALTtKIPDTKGCHKCCIVRNPYtgHKYLCGALQSGIVLLQWYEPMQKFMLIKHF-D 665
Cdd:smart00036  79 K----------EALGSARLVIRKNVLT-KIPDVKGCHLCAVVNGKR--SLFLCVALQSSVVLLQWYNPLKKFKLFKSKfL 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    666 FPLPSPLNVFEMLVIPEQEYPMVCVAISKGteSNQVVQFE--TINLNSASSWFTEIGAGSqqlDSIHVTQLERDTVLVCL 743
Cdd:smart00036 146 FPLISPVPVFVELVSSSFERPGICIGSDKG--GGDVVQFHesLVSKEDLSLPFLSEETSL---KPISVVQVPRDEVLLCY 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    744 DKFVKIVNLQGKlksSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISD-ETRVFRLLG-SDRVVV 821
Cdd:smart00036 221 DEFGVFVNLYGK---RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADrETRKIRLLGsSDRKIL 297

                   ....*
gi 38570135    822 LESRP 826
Cdd:smart00036 298 LSSSP 302
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
15-286 1.30e-101

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 316.30  E-value: 1.30e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06611   2 NPNDIWEIIGELGDGAFGKVYKAQHKETGLFAAAKIIQIESEEELEDFMVEIDILSECKHPNIVGLYEAYFYENKLWILI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06611  82 EFCDGGALDSIMLELErGLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGVSAKNKSTLQKRD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVE--KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTKWSSTFH 251
Cdd:cd06611 162 TFIGTPYWMAPEVVACEtfKDNPYDYKADIWSLGITLIELAQMEPPHHELNPMRVLLKILKS--EPPTLDQPSKWSSSFN 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRAL 286
Cdd:cd06611 240 DFLKSCLVKDPDDRPTAAELLKHPFVSDQSDNKAI 274
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
14-277 9.28e-90

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 285.36  E-value: 9.28e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLSR----- 87
Cdd:cd06636  12 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKKySHHRNIATYYGAFIKKsppgh 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 -EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd06636  91 dDQLWLVMEFCGAGSVTDLVKNTkgNALKEDWIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKD 242
Cdd:cd06636 171 LDRTVGRRNTFIGTPYWMAPEVIACDENpdATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPKLKS 248
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 243 KtKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06636 249 K-KWSKKFIDFIEGCLVKNYLSRPSTEQLLKHPFI 282
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
12-286 4.64e-88

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 281.15  E-value: 4.64e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  12 LRR--NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06644   4 VRRdlDPNEVWEIIGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYMVEIEILATCNHPYIVKLLGAFYWDGK 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd06644  84 LWIMIEFCPGGAVDAIMlELDRGLTEPQIQVICRQMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVSAKNVKT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKSFIGTPYWMAPEVAAVE--KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTKW 246
Cdd:cd06644 164 LQRRDSFIGTPYWMAPEVVMCEtmKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--EPPTLSQPSKW 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRAL 286
Cdd:cd06644 242 SMEFRDFLKTALDKHPETRPSAAQLLEHPFVSSVTSNRPL 281
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
20-277 1.45e-86

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 275.56  E-value: 1.45e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDrERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRKSFIGT 178
Cdd:smart00220  81 GGDLFDLLKKRGRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPG-EKLTTFVGT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF-LMSKSNFQPPklKDKTKWSSTFHNFVKIA 257
Cdd:smart00220 160 PEYMAPEVL---LGKGYGKAVDIWSLGVILYELLTGKPPFPGDDQLLELFkKIGKPKPPFP--PPEWDISPEAKDLIRKL 234
                          250       260
                   ....*....|....*....|
gi 38570135    258 LTKNPKKRPTAERLLTHTFV 277
Cdd:smart00220 235 LVKDPEKRLTAEEALQHPFF 254
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
20-277 6.97e-86

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 273.72  E-value: 6.97e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd06627   2 YQLGDLIGRGAFGSVYKGLNLNTGEFVAIKQISLEkiPKSDLKSVMGEIDLLKKLNHPNIVKYIGSVKTKDSLYIILEYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177
Cdd:cd06627  82 ENGSLASIIKKFGKFPESLVAVYIYQVLEGLAYLHEQGVIHRDIKGANILTTKDGLVKLADFGVATKLNEVEKDENSVVG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSkSNFQPPKLKDKtkwSSTFHNFVKIA 257
Cdd:cd06627 162 TPYWMAPEVIEMS---GVTTASDIWSVGCTVIELLTGNPPYYDLQPMAALFRIV-QDDHPPLPENI---SPELRDFLLQC 234
                       250       260
                ....*....|....*....|
gi 38570135 258 LTKNPKKRPTAERLLTHTFV 277
Cdd:cd06627 235 FQKDPTLRPSAKELLKHPWL 254
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
14-295 5.15e-85

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 273.13  E-value: 5.15e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLSR----- 87
Cdd:cd06637   2 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKySHHRNIATYYGAFIKKnppgm 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 -EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd06637  81 dDQLWLVMEFCGAGSVTDLIKNTkgNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKD 242
Cdd:cd06637 161 LDRTVGRRNTFIGTPYWMAPEVIACDENpdATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 243 KtKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN 295
Cdd:cd06637 239 K-KWSKKFQSFIESCLVKNHSQRPSTEQLMKHPFIRDQPNERQVRIQLKDHID 290
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
15-293 1.37e-84

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 271.55  E-value: 1.37e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd06642   1 DPEELFTKLERIGKGSFGEVYKGIDNRTKEVVAIKIIDLEEAEDeIEDIQQEITVLSQCDSPYITRYYGSYLKGTKLWII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06642  81 MEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDktKWSSTFHNF 253
Cdd:cd06642 160 TFVGTPFWMAPEVI---KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS--PPTLEG--QHSKPFKEF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDK 293
Cdd:cd06642 233 VEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDR 272
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
19-276 1.51e-83

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 268.07  E-value: 1.51e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd06610   2 DYELIEVIGSGATAVVYAAYCLPKKEKVAIKRIDLEKCQtSMDELRKEIQAMSQCNHPNVVSYYTSFVVGDELWLVMPLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDI--YHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI----TATIA 170
Cdd:cd06610  82 SGGSLLDImkSSYpRGGLDEAIIATVLKEVLKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVSASLatggDRTRK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKL---KDKTKWS 247
Cdd:cd06610 162 VRKTFVGTPCWMAPEV--MEQVRGYDFKADIWSFGITAIELATGAAPYSKYPPMKVLMLTLQND--PPSLetgADYKKYS 237
                       250       260
                ....*....|....*....|....*....
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd06610 238 KSFRKMISLCLQKDPSKRPTAEELLKHKF 266
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
15-278 1.62e-82

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 266.12  E-value: 1.62e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06643   2 NPEDFWEIVGELGDGAFGKVYKAQNKETGILAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06643  82 EFCAGGAVDAVMlELERPLTEPQIRVVCKQTLEALVYLHENKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTLQRRD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVE--KNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTKWSSTFH 251
Cdd:cd06643 162 SFIGTPYWMAPEVVMCEtsKDRPYDYKADVWSLGVTLIEMAQIEPPHHELNPMRVLLKIAKS--EPPTLAQPSRWSPEFK 239
                       250       260
                ....*....|....*....|....*..
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd06643 240 DFLRKCLEKNVDARWTTSQLLQHPFVS 266
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
15-293 2.83e-81

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 262.70  E-value: 2.83e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd06641   1 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDeIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06641  81 MEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDktKWSSTFHNF 253
Cdd:cd06641 160 *FVGTPFWMAPEVI---KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN--PPTLEG--NYSKPLKEF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDK 293
Cdd:cd06641 233 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDR 272
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
15-293 2.99e-80

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 259.98  E-value: 2.99e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd06640   1 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDeIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06640  81 MEYLGGGSALDLLR-AGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKsnFQPPKLKDktKWSSTFHNF 253
Cdd:cd06640 160 TFVGTPFWMAPEVI---QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPK--NNPPTLVG--DFSKPFKEF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDK 293
Cdd:cd06640 233 IDACLNKDPSFRPTAKELLKHKFIVKNAKKTSYLTELIDR 272
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
20-279 7.16e-79

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 255.45  E-value: 7.16e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL---EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06607   3 FEDLREIGHGSFGAVYYARNKRTSEVVAIKKMSYsgkQSTEKWQDIIKEVKFLRQLRHPNTIEYKGCYLREHTAWLVMEY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGgSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAakitATIAKRKSF 175
Cdd:cd06607  83 CLG-SASDIVEVhKKPLQEVEIAAICHGALQGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSA----SLVCPANSF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKdKTKWSSTFHNFVK 255
Cdd:cd06607 158 VGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQND--SPTLS-SGEWSDDFRNFVD 234
                       250       260
                ....*....|....*....|....
gi 38570135 256 IALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06607 235 SCLQKIPQDRPSAEDLLKHPFVTR 258
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
16-295 1.37e-78

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 255.48  E-value: 1.37e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVqrvGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKHC---NIVAYFGSYLSREKLW 91
Cdd:cd06917   2 LYRRLELV---GRGSYGAVYRGYHVKTGRVVALKVLNLDtDDDDVSDIQKEVALLSQLKLGqpkNIIKYYGSYLKGPSLW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd06917  79 IIMDYCEGGSIRTLMR-AGPIAERYIAVIMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAASLNQNSSK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTkWSSTFH 251
Cdd:cd06917 158 RSTFVGTPYWMAPEV--ITEGKYYDTKADIWSLGITTYEMATGNPPYSDVDALRAVMLIPKS--KPPRLEGNG-YSPLLK 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFV-AQPGLSRALAVELLDKVN 295
Cdd:cd06917 233 EFVAACLDEEPKDRLSADELLKSKWIkQHSKTPTSVLKELISRYN 277
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
15-277 2.86e-78

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 254.94  E-value: 2.86e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIikLEPGDDF-SLIQQEIFMVKECK-HCNIVAYFGSYLSRE---- 88
Cdd:cd06638  15 DPSDTWEIIETIGKGTYGKVFKVLNKKNGSKAAVKI--LDPIHDIdEEIEAEYNILKALSdHPNVVKFYGMYYKKDvkng 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 -KLWICMEYCGGGSLQDIyhVTGPL------SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd06638  93 dQLWLVLELCNGGSVTDL--VKGFLkrgermEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNILLTTEGGVKLVDFGV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRKSFIGTPYWMAPEVAAVEK--NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPK 239
Cdd:cd06638 171 SAQLTSTRLRRNTSVGTPFWMAPEVIACEQqlDSTYDARCDVWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPT 248
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06638 249 LHQPELWSNEFNDFIRKCLTKDYEKRPTVSDLLQHVFI 286
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
19-277 9.83e-76

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 247.05  E-value: 9.83e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06606   1 RWKKGELLGKGSFGSVYLALNLDTGELMAVKEVELSGDSEEELeaLEREIRILSSLKHPNIVRYLGTERTENTLNIFLEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI--TATIAKRKS 174
Cdd:cd06606  81 VPGGSLASLLKKFGKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAKRLaeIATGEGTKS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLH-PMRALFLMSKSNfQPPKLKDKTkwSSTFHNF 253
Cdd:cd06606 161 LRGTPYWMAPEVI---RGEGYGRAADIWSLGCTVIEMATGKPPWSELGnPVAALFKIGSSG-EPPPIPEHL--SEEAKDF 234
                       250       260
                ....*....|....*....|....
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06606 235 LRKCLQRDPKKRPTADELLQHPFL 258
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
15-277 1.21e-71

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 236.36  E-value: 1.21e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06647   4 DPKKKYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06647  84 EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFV 254
Cdd:cd06647 163 MVGTPYWMAPEVVTRKA---YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSAIFRDFL 237
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06647 238 NRCLEMDVEKRGSAKELLQHPFL 260
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
15-277 2.73e-70

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 233.73  E-value: 2.73e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIikLEPGDDF-SLIQQEIFMVKEC-KHCNIVAYFGSYLSREK--- 89
Cdd:cd06639  19 DPSDTWDIIETIGKGTYGKVYKVTNKKDGSLAAVKI--LDPISDVdEEIEAEYNILRSLpNHPNVVKFYGMFYKADQyvg 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 --LWICMEYCGGGSLQDIyhVTG------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd06639  97 gqLWLVLELCNGGSVTEL--VKGllkcgqRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRKSFIGTPYWMAPEVAAVEK--NGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPK 239
Cdd:cd06639 175 SAQLTSARLRRNTSVGTPFWMAPEVIACEQqyDYSYDARCDVWSLGITAIELADGDPPLFDMHPVKALFKIPRN--PPPT 252
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06639 253 LLNPEKWCRGFSHFISQCLIKDFEKRPSVTHLLEHPFI 290
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
24-277 3.06e-70

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 232.29  E-value: 3.06e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-----IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd06632   6 QLLGSGSFGSVYEGFNGDTGDFFAVKEVSLVDDDKKSResvkqLEQEIALLSKLRHPNIVQYYGTEREEDNLYIFLEYVP 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAKRKSFIGT 178
Cdd:cd06632  86 GGSIHKLLQRYGAFEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGM-AKHVEAFSFAKSFKGS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAAvEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPP---KLKDKTKwsstfhNFVK 255
Cdd:cd06632 165 PYWMAPEVIM-QKNSGYGLAVDIWSLGCTVLEMATGKPPWSQYEGVAAIFKIGNSGELPPipdHLSPDAK------DFIR 237
                       250       260
                ....*....|....*....|..
gi 38570135 256 IALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06632 238 LCLQRDPEDRPTASQLLEHPFV 259
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
9-299 6.90e-69

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 230.69  E-value: 6.90e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   9 ADIL-RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL---EPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84
Cdd:cd06633  11 ADLFyKDDPEEIFVDLHEIGHGSFGAVYFATNSHTNEVVAIKKMSYsgkQTNEKWQDIIKEVKFLQQLKHPNTIEYKGCY 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  85 LSREKLWICMEYCGGgSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd06633  91 LKDHTAWLVMEYCLG-SASDLLEVhKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSAS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATiakrKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKdK 243
Cdd:cd06633 170 IASPA----NSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQND--SPTLQ-S 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 244 TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALaVELL----DKVNNPDN 299
Cdd:cd06633 243 NEWTDSFRGFVDYCLQKIPQERPSSAELLRHDFVRRERPPRVL-IDLIqrtkDAVRELDN 301
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
15-278 1.02e-67

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 225.78  E-value: 1.02e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06648   4 DPRSDLDNFVKIGEGSTGIVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIyhVT-GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd06648  84 EFLEGGALTDI--VThTRMNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGFCAQVSKEVPRRK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTKWSSTFHNF 253
Cdd:cd06648 162 SLVGTPYWMAPEVISRLP---YGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRIRDN--EPPKLKNLHKVSPRLRSF 236
                       250       260
                ....*....|....*....|....*
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd06648 237 LDRMLVRDPAQRATAAELLNHPFLA 261
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
2-286 3.16e-66

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 222.94  E-value: 3.16e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   2 EAPLRPAADilRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYF 81
Cdd:cd06659   7 KAALRMVVD--QGDPRQLLENYVKIGEGSTGVVCIAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHPNVVEMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  82 GSYLSREKLWICMEYCGGGSLQDIYHVTgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd06659  85 KSYLVGEELWVLMEYLQGGALTDIVSQT-RLNEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLK 241
Cdd:cd06659 164 CAQISKDVPKRKSLVGTPYWMAPEVIS---RCPYGTEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS--PPPKLK 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 38570135 242 DKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRAL 286
Cdd:cd06659 239 NSHKASPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECL 283
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
15-280 7.57e-65

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 219.21  E-value: 7.57e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06654  17 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06654  97 EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFV 254
Cdd:cd06654 176 MVGTPYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSAIFRDFL 250
                       250       260
                ....*....|....*....|....*...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTF--VAQP 280
Cdd:cd06654 251 NRCLEMDVEKRGSAKELLQHQFlkIAKP 278
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
12-277 1.72e-64

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 218.77  E-value: 1.72e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  12 LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL---EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSRE 88
Cdd:cd06635  19 FKEDPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYsgkQSNEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREH 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGgSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd06635  99 TAWLVMEYCLG-SASDLLEVhKKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASP 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TiakrKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKdKTKWS 247
Cdd:cd06635 178 A----NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPTLQ-SNEWS 250
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06635 251 DYFRNFVDSCLQKIPQDRPTSEELLKHMFV 280
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
26-277 2.84e-64

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 216.07  E-value: 2.84e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-----DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd06625   8 LGQGAFGQVYLCYDADTGRELAVKQVEIDPINteaskEVKALECEIQLLKNLQHERIVQYYGCLQDEKSLSIFMEYMPGG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKITATIAKR---KSFIG 177
Cdd:cd06625  88 SVKDEIKAYGALTENVTRKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFG-ASKRLQTICSStgmKSVTG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAavekNG-GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKsnfQPPKLKDKTKWSSTFHNFVKI 256
Cdd:cd06625 167 TPYWMSPEVI----NGeGYGRKADIWSVGCTVVEMLTTKPPWAEFEPMAAIFKIAT---QPTNPQLPPHVSEDARDFLSL 239
                       250       260
                ....*....|....*....|.
gi 38570135 257 ALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06625 240 IFVRNKKQRPSAEELLSHSFV 260
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
15-280 2.31e-63

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 214.97  E-value: 2.31e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06656  16 DPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06656  96 EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRST 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFV 254
Cdd:cd06656 175 MVGTPYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFL 249
                       250       260
                ....*....|....*....|....*...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTF--VAQP 280
Cdd:cd06656 250 NRCLEMDVDRRGSAKELLQHPFlkLAKP 277
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
19-277 3.67e-63

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 213.22  E-value: 3.67e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd06623   2 DLERVKVLGQGSSGVVYKVRHKPTGKIYALKKIHVDGDEEFrKQLLRELKTLRSCESPYVVKCYGAFYKEGEISIVLEYM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKM-HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd06623  82 DGGSLADLLKKVGKIPEPVLAYIARQILKGLDYLHTKRHIiHRDIKPSNLLINSKGEVKIADFGISKVLENTLDQCNTFV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKI 256
Cdd:cd06623 162 GTVTYMSPERIQGES---YSYAADIWSLGLTLLECALGKFPFLPPGQPSFFELMQAICDGPPPSLPAEEFSPEFRDFISA 238
                       250       260
                ....*....|....*....|.
gi 38570135 257 ALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06623 239 CLQKDPKKRPSAAELLQHPFI 259
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
19-277 4.47e-63

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 212.71  E-value: 4.47e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd08215   1 KYEKIRVIGKGSFGSAYLVRRKSDGKLYVLKEIDLSnmSEKEREEALNEVKLLSKLKHPNIVKYYESFEENGKLCIVMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIY----HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd08215  81 ADGGDLAQKIkkqkKKGQPFPEEQILDWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFGISKVLESTTDLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLM-SKSNFQPPklkdKTKWSSTFH 251
Cdd:cd08215 161 KTVVGTPYYLSPELC---ENKPYNYKSDIWALGCVLYELCTLKHP-FEANNLPALVYKiVKGQYPPI----PSQYSSELR 232
                       250       260
                ....*....|....*....|....*.
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08215 233 DLVNSMLQKDPEKRPSANEILSSPFI 258
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
13-277 3.65e-62

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 212.19  E-value: 3.65e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  13 RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL---EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd06634  10 KDDPEKLFSDLREIGHGSFGAVYFARDVRNNEVVAIKKMSYsgkQSNEKWQDIIKEVKFLQKLRHPNTIEYRGCYLREHT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGgSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAkitaT 168
Cdd:cd06634  90 AWLVMEYCLG-SASDLLEVhKKPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSAS----I 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKdKTKWSS 248
Cdd:cd06634 165 MAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN--ESPALQ-SGHWSE 241
                       250       260
                ....*....|....*....|....*....
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06634 242 YFRNFVDSCLQKIPQDRPTSDVLLKHRFL 270
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
24-277 4.09e-62

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 210.62  E-value: 4.09e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD--FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd06626   6 NKIGEGTFGKVYTAVNLDTGELMAMKEIRFQDNDPktIKEIADEMKVLEGLDHPNLVRYYGVEVHREEVYIFMEYCQEGT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-----TATIAKRKSFI 176
Cdd:cd06626  86 LEELLRHGRILDEAVIRVYTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAVKLknnttTMAPGEVNSLV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLhpmralflmsKSNFQ---------PPKLKDKTKWS 247
Cdd:cd06626 166 GTPAYMAPEVITGNKGEGHGRAADIWSLGCVVLEMATGKRPWSEL----------DNEWAimyhvgmghKPPIPDSLQLS 235
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06626 236 PEGKDFLSRCLESDPKKRPTASELLDHPFI 265
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
15-280 7.41e-62

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 211.12  E-value: 7.41e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06655  16 DPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSFLVGDELFVVM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06655  96 EYLAGGSLTDVVTETC-MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRST 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFV 254
Cdd:cd06655 175 MVGTPYWMAPEVVTRK---AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSPIFRDFL 249
                       250       260
                ....*....|....*....|....*...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTF--VAQP 280
Cdd:cd06655 250 NRCLEMDVEKRGSAKELLQHPFlkLAKP 277
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
18-279 1.04e-61

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 209.51  E-value: 1.04e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGddfSLIQQEIFM----VKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd06605   1 DDLEYLGELGEGNGGVVSKVRHRPSGQIMAVKVIRLEID---EALQKQILReldvLHKCNSPYIVGFYGAFYSEGDISIC 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATIAkr 172
Cdd:cd06605  78 MEYMDGGSLDKILKEVGRIPERILGKIAVAVVKGLIYLHEKHKiIHRDVKPSNILVNSRGQVKLCDFGVSGQLVDSLA-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQ---PPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSST 249
Cdd:cd06605 156 KTFVGTRSYMAPERI---SGGKYTVKSDIWSLGLSLVELATGRfpyPPPNAKPSMMIFELLSYIVDEPPPLLPSGKFSPD 232
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06605 233 FQDFVSQCLQKDPTERPSYKELMEHPFIKR 262
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
27-277 4.84e-58

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 199.20  E-value: 4.84e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARnVHTGELAAVKIIKLEPGD------DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd06631  10 GKGAYGTVYCGL-TSTGQLIAVKQVELDTSDkekaekEYEKLQEEVDLLKTLKHVNIVGYLGTCLEDNVVSIFMEFVPGG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR------KS 174
Cdd:cd06631  89 SIASILARFGALEEPVFCRYTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAKRLCINLSSGsqsqllKS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDktKWSSTFHNFV 254
Cdd:cd06631 169 MRGTPYWMAPEVI---NETGHGRKSDIWSIGCTVFEMATGKPPWADMNPMAAIFAIGSGRKPVPRLPD--KFSPEARDFV 243
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06631 244 HACLTRDQDERPSAEQLLKHPFI 266
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
19-274 7.22e-58

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 198.47  E-value: 7.22e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd05117   1 KYELGKVLGRGSFGVVRLAVHKKTGEEYAVKIIdkKKLKSEDEEMLRREIEILKRLDHPNIVKLYEVFEDDKNLYLVMEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---DHGDVKLADFGVAAKITATIaKRK 173
Cdd:cd05117  81 CTGGELFDRIVKKGSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLAskdPDSPIKIIDFGLAKIFEEGE-KLK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVG-ITAIEL-GElqPPmFDLHPMRALF---LMSKSNFQPPKLKDKtkwSS 248
Cdd:cd05117 160 TVCGTPYYVAPEVL---KGKGYGKKCDIWSLGvILYILLcGY--PP-FYGETEQELFekiLKGKYSFDSPEWKNV---SE 230
                       250       260
                ....*....|....*....|....*.
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd05117 231 EAKDLIKRLLVVDPKKRLTAAEALNH 256
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
15-281 1.31e-56

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 196.41  E-value: 1.31e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd06658  19 DPREYLDSFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVM 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd06658  99 EFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKS 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnfQPPKLKDKTKWSSTFHNFV 254
Cdd:cd06658 178 LVGTPYWMAPEVIS---RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDN--LPPRVKDSHKVSSVLRGFL 252
                       250       260
                ....*....|....*....|....*..
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFVAQPG 281
Cdd:cd06658 253 DLMLVREPSQRATAQELLQHPFLKLAG 279
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
27-274 3.99e-55

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 189.40  E-value: 3.99e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD- 104
Cdd:cd00180   2 GKGSFGKVYKARDKETGKKVAVKVIPKEkLKKLLEELLREIEILKKLNHPNIVKLYDVFETENFLYLVMEYCEGGSLKDl 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG--TPYWM 182
Cdd:cd00180  82 LKENKGPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGttPPYYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 183 APEVAaveKNGGYNQLCDIWAVGITAIELGELQppmfdlhpmralflmsksnfqppklkdktkwsstfhNFVKIALTKNP 262
Cdd:cd00180 162 PPELL---GGRYYGPKVDIWSLGVILYELEELK------------------------------------DLIRRMLQYDP 202
                       250
                ....*....|..
gi 38570135 263 KKRPTAERLLTH 274
Cdd:cd00180 203 KKRPSAKELLEH 214
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
25-277 2.95e-54

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 189.56  E-value: 2.95e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfslIQQEIF----MVKECKHCNIVAYFGSYL--SREKLWICMEYCG 98
Cdd:cd06621   8 SLGEGAGGSVTKCRLRNTKTIFALKTITTDPNPD---VQKQILreleINKSCASPYIVKYYGAFLdeQDSSIGIAMEYCE 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIY----HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAkrKS 174
Cdd:cd06621  85 GGSLDSIYkkvkKKGGRIGEKVLGKIAESVLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSGELVNSLA--GT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQ---PPMFDLHPMRALFLMSKSNFQPPKLKD----KTKWS 247
Cdd:cd06621 163 FTGTSYYMAPERI---QGGPYSITSDVWSLGLTLLEVAQNRfpfPPEGEPPLGPIELLSYIVNMPNPELKDepenGIKWS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06621 240 ESFKDFIEKCLEKDGTRRPGPWQMLAHPWI 269
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
20-268 1.97e-53

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 186.25  E-value: 1.97e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD---FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14014   2 YRLVRLLGRGGMGEVYRARDTLLGRPVAIKVLRPELAEDeefRERFLREARALARLSHPNIVRVYDVGEDDGRPYIVMEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR-KSF 175
Cdd:cd14014  82 VEGGSLADLLRERGPLPPREALRILAQIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALGDSGLTQtGSV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSStFHNFVK 255
Cdd:cd14014 162 LGTPAYMAPEQA---RGGPVDPRSDIYSLGVVLYELLTGRPPFDGDSPAAVLAKHLQEAPPPPSPLNPDVPPA-LDAIIL 237
                       250
                ....*....|...
gi 38570135 256 IALTKNPKKRPTA 268
Cdd:cd14014 238 RALAKDPEERPQS 250
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
25-281 9.73e-53

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 185.61  E-value: 9.73e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd06657  27 KIGEGSTGIVCIATVKSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Cdd:cd06657 107 IVTHT-RMNEEQIAAVCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 185 EVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALfLMSKSNFqPPKLKDKTKWSSTFHNFVKIALTKNPKK 264
Cdd:cd06657 186 ELIS---RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAM-KMIRDNL-PPKLKNLHKVSPSLKGFLDRLLVRDPAQ 260
                       250
                ....*....|....*..
gi 38570135 265 RPTAERLLTHTFVAQPG 281
Cdd:cd06657 261 RATAAELLKHPFLAKAG 277
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
26-267 3.67e-51

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 179.66  E-value: 3.67e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd13999   1 IGSGSFGEVYKGK--WRGTDVAIKKLKVEDDNDELLkeFRREVSILSKLRHPNIVQFIGACLSPPPLCIVTEYMPGGSLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYH-VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWM 182
Cdd:cd13999  79 DLLHkKKIPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKNSTTEKMTGVVGTPRWM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 183 APEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDktkWSSTFHNFVKIALTKNP 262
Cdd:cd13999 159 APEVL---RGEPYTEKADVYSFGIVLWELLTGEVPFKELSPIQIAAAVVQKGLRPPIPPD---CPPELSKLIKRCWNEDP 232

                ....*
gi 38570135 263 KKRPT 267
Cdd:cd13999 233 EKRPS 237
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
522-815 4.05e-51

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 180.13  E-value: 4.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   522 DQYIIFGTEDGIYTLNLNelHEATMEQLF-PRKCTWLYVIN--NTLMSLSeGKTFQLYSHNLIALFehakkpglaahiqt 598
Cdd:pfam00780   2 GQNLLLGTEEGLYVLNRS--GPREPVRIIdKKRVTQLAVLEefNLLLLLS-GKDKRLYVYPLSALD-------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   599 hrfPDRILPRKFALTTKIPDTKGCHKCCIVRNpyTGHKYLCGALQSGIVLLQWYEPMQ-KFMLIKHFDFPLPSPlnVFEM 677
Cdd:pfam00780  65 ---SREENDRKDAAKNKLPETKGCHFFKVGRH--SNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPV--SIEL 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   678 LVipeqeyPMVCVAISKGtesnqvvqFETINLNSASSW----FTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQ 753
Cdd:pfam00780 138 LK------SKLCVGCAKG--------FEIVSLDSKATEslltSLLFANRQENLKPLAVVRLDRSEFLLCYNEFGVYVNLQ 203
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135   754 GKLKSSkklaSELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLG 815
Cdd:pfam00780 204 GRRSRP----WEIEWEGAPEAVAYLYPYLLAFHDNFIEIRDVETGELVQEIAGRKIRFLNSG 261
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
26-277 2.07e-50

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 178.11  E-value: 2.07e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD---------FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06628   8 IGSGSFGSVYLGMNASSGELMAVKQVELPSVSAenkdrkksmLDALQREIALLRELQHENIVQYLGSSSDANHLNIFLEY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI------TATIA 170
Cdd:cd06628  88 VPGGSVATLLNNYGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLeanslsTKNNG 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMskSNFQPPKLKDKTkwSSTF 250
Cdd:cd06628 168 ARPSLQGSVFWMAPEVV---KQTSYTRKADIWSLGCLVVEMLTGTHPFPDCTQMQAIFKI--GENASPTIPSNI--SSEA 240
                       250       260
                ....*....|....*....|....*..
gi 38570135 251 HNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06628 241 RDFLEKTFEIDHNKRPTADELLKHPFL 267
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
24-277 2.12e-50

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 178.34  E-value: 2.12e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD----------FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd06629   7 ELIGKGTYGRVYLAMNATTGEMLAVKQVELPKTSSdradsrqktvVDALKSEIDTLKDLDHPNIVQYLGFEETEDYFSIF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV---AAKITATIA 170
Cdd:cd06629  87 LEYVPGGSIGSCLRKYGKFEEDLVRFFTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGIskkSDDIYGNNG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KrKSFIGTPYWMAPEVaaVEKNG-GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPkLKDKTKWSST 249
Cdd:cd06629 167 A-TSMQGSVFWMAPEV--IHSQGqGYSAKVDIWSLGCVVLEMLAGRRPWSDDEAIAAMFKLGNKRSAPP-VPEDVNLSPE 242
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06629 243 ALDFLNACFAIDPRDRPTAAELLSHPFL 270
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
20-272 3.13e-49

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 181.36  E-value: 3.13e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLI---QQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:COG0515   9 YRILRLLGRGGMGVVYLARDLRLGRPVALKVLRPELAADPEARerfRREARALARLNHPNIVRVYDVGEEDGRPYLVMEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AKITATIAKRKSF 175
Cdd:COG0515  89 VEGESLADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIArALGGATLTQTGTV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVK 255
Cdd:COG0515 169 VGTPGYMAPEQAR---GEPVDPRSDVYSLGVTLYELLTGRPP-FDGDSPAELLRAHLREPPPPPSELRPDLPPALDAIVL 244
                       250
                ....*....|....*...
gi 38570135 256 IALTKNPKKRP-TAERLL 272
Cdd:COG0515 245 RALAKDPEERYqSAAELA 262
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
19-274 1.35e-48

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 172.70  E-value: 1.35e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14003   1 NYELGKTLGEGSFGKVKLARHKLTGEKVAIKIIDKSklKEEIEEKIKREIEIMKLLNHPNIIKLYEVIETENKIYLVMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITaTIAKRKSFI 176
Cdd:cd14003  81 ASGGELFDYIVNNGRLSEDEARRFFQQLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFR-GGSLLKTFC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVaaVEKNGGYNQLCDIWAVGIT--AIELGELqPpmFDLHPMRALF--LMSKSNFQPPKLkdktkwSSTFHN 252
Cdd:cd14003 160 GTPAYAAPEV--LLGRKYDGPKADVWSLGVIlyAMLTGYL-P--FDDDNDSKLFrkILKGKYPIPSHL------SPDARD 228
                       250       260
                ....*....|....*....|..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14003 229 LIRRMLVVDPSKRITIEEILNH 250
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
18-279 1.76e-48

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 173.39  E-value: 1.76e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpgDDFSLIQQ---EIFMVKECKHCNIVAYFGSYLSRE-KLWIC 93
Cdd:cd06620   5 QDLETLKDLGAGNGGSVSKVLHIPTGTIMAKKVIHID--AKSSVRKQilrELQILHECHSPYIVSFYGAFLNENnNIIIC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATIAkr 172
Cdd:cd06620  83 MEYMDCGSLDKILKKKGPFPEEVLGKIAVAVLEGLTYLYNVHRiIHRDIKPSNILVNSKGQIKLCDFGVSGELINSIA-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL--GEL------QPPMFDLHPMRALFLMSK-SNFQPPKLKDK 243
Cdd:cd06620 161 DTFVGTSTYMSPERI---QGGKYSVKSDVWSLGLSIIELalGEFpfagsnDDDDGYNGPMGILDLLQRiVNEPPPRLPKD 237
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 244 TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06620 238 RIFPKDLRDFVDRCLLKDPRERPSPQLLLDHDPFIQ 273
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
19-277 3.09e-47

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 169.44  E-value: 3.09e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-----DDFSLIQQEIFMVKECKHCNIVAYFGSYLSRE--KLW 91
Cdd:cd06653   3 NWRLGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPDsqetsKEVNALECEIQLLKNLRHDRIVQYYGCLRDPEekKLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITaTIAK 171
Cdd:cd06653  83 IFVEYMPGGSVKDQLKAYGALTENVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQ-TICM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 R----KSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFlmsKSNFQP--PKLKDKTk 245
Cdd:cd06653 162 SgtgiKSVTGTPYWMSPEVISGE---GYGRKADVWSVACTVVEMLTEKPPWAEYEAMAAIF---KIATQPtkPQLPDGV- 234
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 246 wSSTFHNFVKIALTKNpKKRPTAERLLTHTFV 277
Cdd:cd06653 235 -SDACRDFLRQIFVEE-KRRPTAEFLLRHPFV 264
Pkinase pfam00069
Protein kinase domain;
20-277 7.69e-47

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 166.27  E-value: 7.69e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD--FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKkkDKNILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHtkgkmhrdikganilltdhgdvkladfgvaakitatiaKRKSFIG 177
Cdd:pfam00069  81 EGGSLFDLLSEKGAFSEREAKFIMKQILEGLESGS--------------------------------------SLTTFVG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   178 TPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTkWSSTFHNFVKIA 257
Cdd:pfam00069 123 TPWYMAPEVL---GGNPYGPKVDVWSLGCILYELLTGKPP-FPGINGNEIYELIIDQPYAFPELPSN-LSEEAKDLLKKL 197
                         250       260
                  ....*....|....*....|
gi 38570135   258 LTKNPKKRPTAERLLTHTFV 277
Cdd:pfam00069 198 LKKDPSKRLTATQALQHPWF 217
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
19-277 2.82e-46

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 166.11  E-value: 2.82e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14007   1 DFEIGKPLGKGKFGNVYLAREKKSGFIVALKVISKSQLQKSGLEHQlrrEIEIQSHLRHPNILRLYGYFEDKKRIYLILE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKSF 175
Cdd:cd14007  81 YAPNGELYKELKKQKRFDEKEAAKYIYQLALALDYLHSKNIIHRDIKPENILLGSNGELKLADFGWSVHAPSN--RRKTF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL--GElqPPmFDLHPMRALFlmskSNFQPPKLKDKTKWSSTFHNF 253
Cdd:cd14007 159 CGTLDYLPPEMV---EGKEYDYKVDIWSLGVLCYELlvGK--PP-FESKSHQETY----KRIQNVDIKFPSSVSPEAKDL 228
                       250       260
                ....*....|....*....|....
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14007 229 ISKLLQKDPSKRLSLEQVLNHPWI 252
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
19-277 1.98e-45

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 163.58  E-value: 1.98e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14002   2 NYHVLELIGEGSFGKVYKGRRKYTGQVVALKFIpkRGKSEKELRNLRQEIEILRKLNHPNIIEMLDSFETKKEFVVVTEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 cGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd14002  82 -AQGELFQILEDDGTLPEEEVRSIAKQLVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCNTLVLTSIK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAvEKNggYNQLCDIWAVGITAIELGELQPPMFdlhpmralflmSKSNFQPPKL--KDKTKW----SSTF 250
Cdd:cd14002 161 GTPLYMAPELVQ-EQP--YDHTADLWSLGCILYELFVGQPPFY-----------TNSIYQLVQMivKDPVKWpsnmSPEF 226
                       250       260
                ....*....|....*....|....*..
gi 38570135 251 HNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14002 227 KSFLQGLLNKDPSKRLSWPDLLEHPFV 253
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
27-277 2.00e-45

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 164.26  E-value: 2.00e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIK--------------LEPGDDFSLIQQEIFMVKECKHCNIVAYFG--SYLSREKL 90
Cdd:cd14008   2 GRGSFGKVKLALDTETGQLYAIKIFNksrlrkrregkndrGKIKNALDDVRREIAIMKKLDHPNIVRLYEviDDPESDKL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDI--YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA---AKI 165
Cdd:cd14008  82 YLVLEYCEGGPVMELdsGDRVPPLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSemfEDG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATIAKRKsfiGTPYWMAPEVAAVEkNGGYN-QLCDIWAVGIT--AIELGELqpPMFDLHPMrALFLMSKSNFQPPKLKD 242
Cdd:cd14008 162 NDTLQKTA---GTPAFLAPELCDGD-SKTYSgKAADIWALGVTlyCLVFGRL--PFNGDNIL-ELYEAIQNQNDEFPIPP 234
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 243 ktKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14008 235 --ELSPELKDLLRRMLEKDPEKRITLKEIKEHPWV 267
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
19-277 2.39e-45

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 164.06  E-value: 2.39e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP-----GDDFSLIQQEIFMVKECKHCNIVAYFGSYL-SREK-LW 91
Cdd:cd06652   3 NWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPespetSKEVNALECEIQLLKNLLHERIVQYYGCLRdPQERtLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKITATI-- 169
Cdd:cd06652  83 IFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFG-ASKRLQTIcl 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 --AKRKSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK--SNFQ-PPKLKDKT 244
Cdd:cd06652 162 sgTGMKSVTGTPYWMSPEVISGE---GYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATqpTNPQlPAHVSDHC 238
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 245 KwsstfhNFVKIALTKnPKKRPTAERLLTHTFV 277
Cdd:cd06652 239 R------DFLKRIFVE-AKLRPSADELLRHTFV 264
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
19-291 1.04e-44

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 163.62  E-value: 1.04e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYgdVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd08216   3 LYEIGKCFKGGGV--VHLAKHKPTNTLVAVKKINLEsdSKEDLKFLQQEILTSRQLQHPNILPYVTSFVVDNDLYVVTPL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd08216  81 MAYGSCRDLLktHFPEGLPELAIAFILRDVLNALEYIHSKGYIHRSVKASHILISGDGKVVLSGLRYAYSMVKHGKRQRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTP-------YWMAPEVaaVEKN-GGYNQLCDIWAVGITAIELGELQPPMFDLHPMraLFLMSKSNFQPPKLKDKT-- 244
Cdd:cd08216 161 VHDFPksseknlPWLSPEV--LQQNlLGYNEKSDIYSVGITACELANGVVPFSDMPAT--QMLLEKVRGTTPQLLDCSty 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 245 ------------------------------KWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELL 291
Cdd:cd08216 237 pleedsmsqsedsstehpnnrdtrdipyqrTFSEAFHQFVELCLQRDPELRPSASQLLAHSFFKQCRRSNTSLLDLL 313
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
19-277 2.20e-44

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 161.17  E-value: 2.20e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSRE--KLWIC 93
Cdd:cd08217   1 DYEVLETIGKGSFGTVRKVRRKSDGKILVWKEIdygKMSEKEKQQLVS-EVNILRELKHPNIVRYYDRIVDRAntTLYIV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDI----YHVTGPLSELQIAYVCRETLQGLAYLHTKGK-----MHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd08217  80 MEYCEGGDLAQLikkcKKENQYIPEEFIWKIFTQLLLALYECHNRSVgggkiLHRDLKPANIFLDSDNNVKLGDFGLARV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKS-NFQP-PKlkd 242
Cdd:cd08217 160 LSHDSSFAKTYVGTPYYMSPELLNEQS---YDEKSDIWSLGCLIYELCALHPP-FQAANQLELAKKIKEgKFPRiPS--- 232
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 243 ktKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08217 233 --RYSSELNEVIKSMLNVDPDKRPSVEELLQLPLI 265
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
17-277 1.06e-43

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 159.50  E-value: 1.06e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELV---QRV--GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd06624   2 EYEYEYDesgERVvlGKGTFGVVYAARDLSTQVRIAIKEIPERDSREVQPLHEEIALHSRLSHKNIVQYLGSVSEDGFFK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVT-GPL--SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLADFGVAAKITA 167
Cdd:cd06624  82 IFMEQVPGGSLSALLRSKwGPLkdNENTIGYYTKQILEGLKYLHDNKIVHRDIKGDNVLVnTYSGVVKISDFGTSKRLAG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEVaaVEKN-GGYNQLCDIWAVGITAIELGELQPPMFDL-HPMRALFL--MSKSNFQ-PPKLKD 242
Cdd:cd06624 162 INPCTETFTGTLQYMAPEV--IDKGqRGYGPPADIWSLGCTIIEMATGKPPFIELgEPQAAMFKvgMFKIHPEiPESLSE 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 243 KTKwsstfhNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06624 240 EAK------SFILRCFEPDPDKRATASDLLQDPFL 268
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
19-272 2.18e-43

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 157.96  E-value: 2.18e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDdfSLIQQ----EIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd08529   1 DFEILNKLGKGSFGVVYKVVRKVDGRVYALKQIDISRMS--RKMREeaidEARVLSKLNSPYVIKYYDSFVDKGKLNIVM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd08529  79 EYAENGDLHSLIKsqRGRPLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDTTNFA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAAvEKngGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQPPklkdKTKWSSTFH 251
Cdd:cd08529 159 QTIVGTPYYLSPELCE-DK--PYNEKSDVWALGCVLYELCTGKHP-FEAQNQGALILkIVRGKYPPI----SASYSQDLS 230
                       250       260
                ....*....|....*....|.
gi 38570135 252 NFVKIALTKNPKKRPTAERLL 272
Cdd:cd08529 231 QLIDSCLTKDYRQRPDTTELL 251
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
19-276 2.92e-43

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 157.72  E-value: 2.92e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14099   2 RYRRGKFLGKGGFAKCYEVTDMSTGKVYAGKVVPKSSLTKPKQrekLKSEIKIHRSLKHPNIVKFHDCFEDEENVYILLE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd14099  82 LCSNGSLMELLKRRKALTEPEVRYFMRQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAARLEYDGERKKTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSN-FQPPKlkdKTKWSSTFHNFV 254
Cdd:cd14099 162 CGTPNYIAPEV--LEKKKGHSFEVDIWSLGVILYTLLVGKPP-FETSDVKETYKRIKKNeYSFPS---HLSISDEAKDLI 235
                       250       260
                ....*....|....*....|..
gi 38570135 255 KIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14099 236 RSMLQPDPTKRPSLDEILSHPF 257
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
19-274 1.56e-41

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 153.01  E-value: 1.56e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14098   1 KYQIIDRLGSGTFAEVKKAVEVETGKMRAIKQIVkrkvAGNDKNLQLFQREINILKSLEHPGIVRLIDWYEDDQHIYLVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD--VKLADFGVaAKITATIAKR 172
Cdd:cd14098  81 EYVEGGDLMDFIMAWGAIPEQHARELTKQILEAMAYTHSMGITHRDLKPENILITQDDPviVKISDFGL-AKVIHTGTFL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEV---AAVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF-LMSKSNFQPPKLKDkTKWSS 248
Cdd:cd14098 160 VTFCGTMAYLAPEIlmsKEQNLQGGYSNLVDMWSVGCLVYVMLTGALP-FDGSSQLPVEkRIRKGRYTQPPLVD-FNISE 237
                       250       260
                ....*....|....*....|....*.
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14098 238 EAIDFILRLLDVDPEKRMTAAQALDH 263
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
26-276 7.21e-41

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 151.39  E-value: 7.21e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEP-----GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSR--EKLWICMEYCG 98
Cdd:cd06651  15 LGQGAFGRVYLCYDVDTGRELAAKQVQFDPespetSKEVSALECEIQLLKNLQHERIVQYYGCLRDRaeKTLTIFMEYMP 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKITATIAKR----KS 174
Cdd:cd06651  95 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG-ASKRLQTICMSgtgiRS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPkLKDKTkwSSTFHNFV 254
Cdd:cd06651 174 VTGTPYWMSPEVISGE---GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQ-LPSHI--SEHARDFL 247
                       250       260
                ....*....|....*....|..
gi 38570135 255 KIALTKnPKKRPTAERLLTHTF 276
Cdd:cd06651 248 GCIFVE-ARHRPSAEELLRHPF 268
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
26-268 1.03e-39

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 147.28  E-value: 1.03e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK---LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05123   1 LGKGSFGKVLLVRKKDTGKLYAMKVLRkkeIIKRKEVEHTLNERNILERVNHPFIVKLHYAFQTEEKLYLVLDYVPGGEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 qdIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Cdd:cd05123  81 --FSHLSkeGRFPEERARFYAAEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKELSSDGDRTYTFCGTPE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 WMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDlHPMRALFlmskSNFQPPKLKDKTKWSSTFHNFVKIALTK 260
Cdd:cd05123 159 YLAPEVL---LGKGYGKAVDWWSLGVLLYEMLTGKPPFYA-ENRKEIY----EKILKSPLKFPEYVSPEAKSLISGLLQK 230

                ....*...
gi 38570135 261 NPKKRPTA 268
Cdd:cd05123 231 DPTKRLGS 238
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
18-276 1.18e-39

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 148.23  E-value: 1.18e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS--LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07833   1 NKYEVLGVVGEGAYGVVLKCRNKATGEIVAIKKFKESEDDEDVkkTALREVKVLRQLRHENIVNLKEAFRRKGRLYLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR-KS 174
Cdd:cd07833  81 YVERTLLELLEASPGGLPPDAVRSYIWQLLQAIAYCHSHNIIHRDIKPENILVSESGVLKLCDFGFARALTARPASPlTD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL--GElqpPMF----DL----HPMRALFLMSKSN---------- 234
Cdd:cd07833 161 YVATRWYRAPELLVGDTN--YGKPVDVWAIGCIMAELldGE---PLFpgdsDIdqlyLIQKCLGPLPPSHqelfssnprf 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 38570135 235 ----FQPPKLKD------KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07833 236 agvaFPEPSQPEslerryPGKVSSPALDFLKACLRMDPKERLTCDELLQHPY 287
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
19-274 1.29e-39

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 147.15  E-value: 1.29e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpgddfSLIQQ-------EIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd08530   1 DFKVLKKLGKGSYGSVYKVKRLSDNQVYALKEVNLG-----SLSQKeredsvnEIRLLASVNHPNIIRYKEAFLDGNRLC 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGslqDIYHV-------TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd08530  76 IVMEYAPFG---DLSKLiskrkkkRRLFPEDDIWRIFIQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKV 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKsfIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKlkdKT 244
Cdd:cd08530 153 LKKNLAKTQ--IGTPLYAAPEVW---KGRPYDYKSDIWSLGCLLYEMATFRPP-FEARTMQELRYKVCRGKFPPI---PP 223
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd08530 224 VYSQDLQQIIRSLLQVNPKKRPSCDKLLQS 253
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
19-274 1.88e-39

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 147.09  E-value: 1.88e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14069   2 DWDLVQTLGEGAFGEVFLAVNRNTEEAVAVKFVdmKRAPGDCPENIKKEVCIQKMLSHKNVVRFYGHRREGEFQYLFLEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKRK--- 173
Cdd:cd14069  82 ASGGELFDKIEPDVGMPEDVAQFYFQQLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGL-----ATVFRYKgke 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 ----SFIGTPYWMAPEVAAveKNGGYNQLCDIWAVGI--TAIELGEL---QPPMFDLhpmralflmSKSNFQPPKLKDKT 244
Cdd:cd14069 157 rllnKMCGTLPYVAPELLA--KKKYRAEPVDVWSCGIvlFAMLAGELpwdQPSDSCQ---------EYSDWKENKKTYLT 225
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 245 KW---SSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14069 226 PWkkiDTAALSLLRKILTENPNKRITIEDIKKH 258
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
20-276 2.22e-39

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 147.30  E-value: 2.22e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07830   1 YKVIKQLGDGTFGSVYLARNKETGELVAIKKMKkkFYSWEECMNLREVKSLRKLNEHPNIVKLKEVFRENDELYFVFEYM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGgSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAtiakRKSF 175
Cdd:cd07830  81 EG-NLYQLMkdRKGKPFSESVIRSIIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAREIRS----RPPY 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 ---IGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQpPMF-------DLHPM-------------RALFLMSK 232
Cdd:cd07830 156 tdyVSTRWYRAPEI--LLRSTSYSSPVDIWALGCIMAELYTLR-PLFpgsseidQLYKIcsvlgtptkqdwpEGYKLASK 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 38570135 233 SNF-----QPPKLKD-KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07830 233 LGFrfpqfAPTSLHQlIPNASPEAIDLIKDMLRWDPKKRPTASQALQHPY 282
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
21-277 3.80e-39

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 146.92  E-value: 3.80e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd06622   4 EVLDELGKGNYGSVYKVLHRPTGVTMAMKEIRLELDEsKFNQIIMELDILHKAVSPYIVDFYGAFFIEGAVYMCMEYMDA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIY---HVTGPLSELQIAYVCRETLQGLAYLHTKGKM-HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKsf 175
Cdd:cd06622  84 GSLDKLYaggVATEGIPEDVLRRITYAVVKGLKFLKEEHNIiHRDVKPTNVLVNGNGQVKLCDFGVSGNLVASLAKTN-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAVE---KNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLKDktKWSSTF 250
Cdd:cd06622 162 IGCQSYMAPERIKSGgpnQNPTYTVQSDVWSLGLSILEMALGRYP-YPPETYANIFaqLSAIVDGDPPTLPS--GYSDDA 238
                       250       260
                ....*....|....*....|....*..
gi 38570135 251 HNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06622 239 QDFVAKCLNKIPNRRPTYAQLLEHPWL 265
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
18-274 4.79e-39

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 146.36  E-value: 4.79e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14046   6 TDFEELQVLGKGAFGQVVKVRNKLDGRYYAIKKIKLRSESKnNSRILREVMLLSRLNHQHVVRYYQAWIERANLYIQMEY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-------AKITATI 169
Cdd:cd14046  86 CEKSTLRDLIDSGLFQDTDRLWRLFRQILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGLAtsnklnvELATQDI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSF-----------IGTPYWMAPEVAAVEKnGGYNQLCDIWAVGITAIELgeLQPP---MFDLHPMRAlfLMSKSNF 235
Cdd:cd14046 166 NKSTSAalgssgdltgnVGTALYVAPEVQSGTK-STYNEKVDMYSLGIIFFEM--CYPFstgMERVQILTA--LRSVSIE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 38570135 236 QPPKLkDKTKWSSTFhNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14046 241 FPPDF-DDNKHSKQA-KLIRWLLNHDPAKRPSAQELLKS 277
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
19-277 1.23e-38

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 145.59  E-value: 1.23e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLIQQEIFMVKECKHC-NIVAYFGSYLSREKLWICMEY 96
Cdd:cd06618  16 DLENLGEIGSGTCGQVYKMRHKKTGHVMAVKqMRRSGNKEENKRILMDLDVVLKSHDCpYIVKCYGYFITDSDVFICMEL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 ---CGGGSLQDIYHvtgPLSELQIAYVCRETLQGLAYLHTK-GKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd06618  96 mstCLDKLLKRIQG---PIPEDILGKMTVSIVKALHYLKEKhGVIHRDVKPSNILLDESGNVKLCDFGISGRLVDSKAKT 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSfIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHN 252
Cdd:cd06618 173 RS-AGCAAYMAPERIDPPDNPKYDIRADVWSLGISLVELATGQFP-YRNCKTEFEVLTKILNEEPPSLPPNEGFSPDFCS 250
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06618 251 FVDLCLTKDHRYRPKYRELLQHPFI 275
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
19-278 2.91e-38

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 144.89  E-value: 2.91e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpgddfslIQQEIF--MVKECK--H-CN---IVAYFGSYLSREKL 90
Cdd:cd06615   2 DFEKLGELGAGNGGVVTKVLHRPSGLIMARKLIHLE-------IKPAIRnqIIRELKvlHeCNspyIVGFYGAFYSDGEI 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06615  75 SICMEHMDGGSLDQVLKKAGRIPENILGKISIAVLRGLTYLREKHKiMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AkrKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIEL-------------------------GELQPPMFDL--H 222
Cdd:cd06615 155 A--NSFVGTRSYMSPERLQGTH---YTVQSDIWSLGLSLVEMaigrypipppdakeleamfgrpvseGEAKESHRPVsgH 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 223 PMR-----ALF--LMSKSNFQPPKLKDKTkWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd06615 230 PPDsprpmAIFelLDYIVNEPPPKLPSGA-FSDEFQDFVDKCLKKNPKERADLKELTKHPFIK 291
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
20-276 5.50e-38

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 143.39  E-value: 5.50e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD----FSLiqQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07829   1 YEKLEKLGEGTYGVVYKAKDKKTGEIVALKKIRLDNEEEgipsTAL--REISLLKELKHPNIVKLLDVIHTENKLYLVFE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGggslQDIYHV----TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd07829  79 YCD----QDLKKYldkrPGPLPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARAFGIPLRT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGitAIeLGEL--QPPMF----DLHpmrALFLMSK-----SNFQPPKL 240
Cdd:cd07829 155 YTHEVVTLWYRAPEILLGSKH--YSTAVDIWSVG--CI-FAELitGKPLFpgdsEID---QLFKIFQilgtpTEESWPGV 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 241 KDKTKWSSTFHNFVKIALTK-------------------NPKKRPTAERLLTHTF 276
Cdd:cd07829 227 TKLPDYKPTFPKWPKNDLEKvlprldpegidllskmlqyNPAKRISAKEALKHPY 281
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
26-274 1.11e-37

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 142.18  E-value: 1.11e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKL------EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd06630   8 LGTGAFSSCYQARDVKTGTLMAVKQVSFcrnsssEQEEVVEAIREEIRMMARLNHPNIVRMLGATQHKSHFNIFVEWMAG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG-DVKLADFGVAAKITATIAKRKSF--- 175
Cdd:cd06630  88 GSVASLLSKYGAFSENVIINYTLQILRGLAYLHDNQIIHRDLKGANLLVDSTGqRLRIADFGAAARLASKGTGAGEFqgq 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 -IGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPP--MFDLHPMRALFLMSKSNFQPPKLKDktKWSSTFHN 252
Cdd:cd06630 168 lLGTIAFMAPEVLRGEQ---YGRSCDVWSVGCVIIEMATAKPPwnAEKISNHLALIFKIASATTPPPIPE--HLSPGLRD 242
                       250       260
                ....*....|....*....|..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTH 274
Cdd:cd06630 243 VTLRCLELQPEDRPPARELLKH 264
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
20-277 1.15e-37

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 141.63  E-value: 1.15e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd08225   2 YEIIKKIGEGSFGKIYLAKAKSDSEHCVIKEIDLTkmPVKEKEASKKEVILLAKMKHPNIVTFFASFQENGRLFIVMEYC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSL-QDIYHVTGPL-SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDV-KLADFGVAAKITATIAKRKS 174
Cdd:cd08225  82 DGGDLmKRINRQRGVLfSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNGMVaKLGDFGIARQLNDSMELAYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQPPklkdKTKWSSTFHNF 253
Cdd:cd08225 162 CVGTPYYLSPEIC---QNRPYNNKTDIWSLGCVLYELCTLKHP-FEGNNLHQLVLkICQGYFAPI----SPNFSRDLRSL 233
                       250       260
                ....*....|....*....|....
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08225 234 ISQLFKVSPRDRPSITSILKRPFL 257
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
16-284 1.44e-37

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 144.20  E-value: 1.44e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:PLN00034  72 SLSELERVNRIGSGAGGTVYKVIHRPTGRLYALKVIYGNHEDTVRRqICREIEILRDVNHPNVVKCHDMFDHNGEIQVLL 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   95 EYCGGGSLQDiYHVTgplSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:PLN00034 152 EFMDGGSLEG-THIA---DEQFLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNS 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  175 FIGTPYWMAPEVAAVEKN-GGYNQLC-DIWAVGITAIE--LGELQPPMF---DLHPMRALFLMSKSNFQPPKLkdktkwS 247
Cdd:PLN00034 228 SVGTIAYMSPERINTDLNhGAYDGYAgDIWSLGVSILEfyLGRFPFGVGrqgDWASLMCAICMSQPPEAPATA------S 301
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 38570135  248 STFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSR 284
Cdd:PLN00034 302 REFRHFISCCLQREPAKRWSAMQLLQHPFILRAQPGQ 338
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
20-277 3.13e-37

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 140.33  E-value: 3.13e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVK---IIKLEPGDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd08218   2 YVRIKKIGEGSFGKALLVKSKEDGKQYVIKeinISKMSPKER-EESRKEVAVLSKMKHPNIVQYQESFEENGNLYIVMDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSL-QDIYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd08218  81 CDGGDLyKRINAQRGvLFPEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVLNSTVELART 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKlkdKTKWSSTFHNFV 254
Cdd:cd08218 161 CIGTPYYLSPEIC---ENKPYNNKSDIWALGCVLYEMCTLKHA-FEAGNMKNLVLKIIRGSYPPV---PSRYSYDLRSLV 233
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08218 234 SQLFKRNPRDRPSINSILEKPFI 256
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
17-273 4.52e-37

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 140.51  E-value: 4.52e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL-EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd13996   5 LNDFEEIELLGSGGFGSVYKVRNKVDGVTYAIKKIRLtEKSSASEKVLREVKALAKLNHPNIVRYYTAWVEEPPLYIQME 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYH---VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-DHGDVKLADFGVAAKITAT--- 168
Cdd:cd13996  85 LCEGGTLRDWIDrrnSSSKNDRKLALELFKQILKGVSYIHSKGIVHRDLKPSNIFLDnDDLQVKIGDFGLATSIGNQkre 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 -----------IAKRKSFIGTPYWMAPEvaaVEKNGGYNQLCDIWAVGITAIELgeLQPP---MFDLHPMRALflmsKSN 234
Cdd:cd13996 165 lnnlnnnnngnTSNNSVGIGTPLYASPE---QLDGENYNEKADIYSLGIILFEM--LHPFktaMERSTILTDL----RNG 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 38570135 235 FQPPKLKDKTKwssTFHNFVKIALTKNPKKRPTAERLLT 273
Cdd:cd13996 236 ILPESFKAKHP---KEADLIQSLLSKNPEERPSAEQLLR 271
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
18-279 1.20e-36

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 139.63  E-value: 1.20e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS-LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06619   1 QDIQYQEILGHGNGGTVYKAYHLLTRRILAVKVIPLDITVELQkQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLqDIYhvtGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAkrKSFI 176
Cdd:cd06619  81 MDGGSL-DVY---RKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIA--KTYV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIEL--GELQPPMF-----DLHPMRALFLMSKSNfqPPKLKDKtKWSST 249
Cdd:cd06619 155 GTNAYMAPERISGEQ---YGIHSDVWSLGISFMELalGRFPYPQIqknqgSLMPLQLLQCIVDED--PPVLPVG-QFSEK 228
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06619 229 FVHFITQCMRKQPKERPAPENLMDHPFIVQ 258
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
19-280 1.67e-36

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 139.81  E-value: 1.67e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD----FSLiqQEIFMVKECKHCNIV----AYFGSYLsrEKL 90
Cdd:cd07845   8 EFEKLNRIGEGTYGIVYRARDTTSGEIVALKKVRMDNERDgipiSSL--REITLLLNLRHPNIVelkeVVVGKHL--DSI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGggslQD----IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd07845  84 FLVMEYCE----QDlaslLDNMPTPFSESQVKCLMLQLLRGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLARTYG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP--------------------------PMFD 220
Cdd:cd07845 160 LPAKPMTPKVVTLWYRAPELLLGCTT--YTTAIDMWAVGCILAELLAHKPllpgkseieqldliiqllgtpnesiwPGFS 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 221 LHPMRALFLMSKsnfQP-PKLKDKTKW-SSTFHNFVKIALTKNPKKRPTAERLLTHT-FVAQP 280
Cdd:cd07845 238 DLPLVGKFTLPK---QPyNNLKHKFPWlSEAGLRLLNFLLMYDPKKRATAEEALESSyFKEKP 297
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
19-279 3.70e-36

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 139.42  E-value: 3.70e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd06650   6 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEikPAIRNQIIR-ELQVLHECNSPYIVGFYGAFYSDGEISICMEH 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATIAkrKSF 175
Cdd:cd06650  85 MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKiMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELG----ELQPP-------MF------------------------- 219
Cdd:cd06650 163 VGTRSYMSPERL---QGTHYSVQSDIWSMGLSLVEMAvgryPIPPPdakelelMFgcqvegdaaetpprprtpgrplssy 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38570135 220 --DLHPMRALF--LMSKSNFQPPKLKDKTkWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06650 240 gmDSRPPMAIFelLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 302
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
20-276 5.05e-36

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 138.08  E-value: 5.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ--QEIFMVKECKHCN------IVAYFGSYLSREKLW 91
Cdd:cd07840   1 YEKIAQIGEGTYGQVYKARNKKTGELVALKKIRMENEKEGFPITaiREIKLLQKLDHPNvvrlkeIVTSKGSAKYKGSIY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGggslQD----IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITa 167
Cdd:cd07840  81 MVFEYMD----HDltglLDNPEVKFTESQIKCYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPYT- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 tiaKRKSFIGTP-----YWMAPEVAAVEKNggYNQLCDIWAVGITAIEL--GElqpPMF----DLHPMRALFLMSKS--- 233
Cdd:cd07840 156 ---KENNADYTNrvitlWYRPPELLLGATR--YGPEVDMWSVGCILAELftGK---PIFqgktELEQLEKIFELCGSpte 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 234 -------------NFQPPK-----LKD--KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07840 228 enwpgvsdlpwfeNLKPKKpykrrLREvfKNVIDPSALDLLDKLLTLDPKKRISADQALQHEY 290
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
20-276 6.10e-36

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 136.60  E-value: 6.10e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgDDFSLIQQEIFMVKECK----HCNIVAYFGSYLSRE--KLWIC 93
Cdd:cd05118   1 YEVLRKIGEGAFGTVWLARDKVTGEKVAIKKIKNDF-RHPKAALREIKLLKHLNdvegHPNIVKLLDVFEHRGgnHLCLV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGggslQDIYHVTG----PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-DHGDVKLADFGVaakitAT 168
Cdd:cd05118  80 FELMG----MNLYELIKdyprGLPLDLIKSYLYQLLQALDFLHSNGIIHRDLKPENILINlELGQLKLADFGL-----AR 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRK---SFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSnFQPPKLKDktk 245
Cdd:cd05118 151 SFTSPpytPYVATRWYRAPEV--LLGAKPYGSSIDIWSLGCILAELLTGRPLFPGDSEVDQLAKIVRL-LGTPEALD--- 224
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 246 wsstfhnFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd05118 225 -------LLSKMLKYDPAKRITASQALAHPY 248
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
19-273 6.24e-36

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 136.64  E-value: 6.24e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL-EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd08219   1 QYNVLRVVGEGSFGRALLVQHVNSDQKYAMKEIRLpKSSSAVEDSRKEAVLLAKMKHPNIVAFKESFEADGHLYIVMEYC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSL-QDIYHVTGPL-SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd08219  81 DGGDLmQKIKLQRGKLfPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLTSPGAYACTY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQP-PklkdkTKWSSTFHNF 253
Cdd:cd08219 161 VGTPYYVPPEIW---ENMPYNNKSDIWSLGCILYELCTLKHP-FQANSWKNLILkVCQGSYKPlP-----SHYSYELRSL 231
                       250       260
                ....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAERLLT 273
Cdd:cd08219 232 IKQMFKRNPRSRPSATTILS 251
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
19-268 1.09e-35

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 136.25  E-value: 1.09e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd08224   1 NYEIEKKIGKGQFSVVYRARCLLDGRLVALKKVQIFEMMDAKARQdclKEIDLLQQLNHPNIIKYLASFIENNELNIVLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSL-QDIYHVTG---PLSELQI----AYVCRetlqGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV----AA 163
Cdd:cd08224  81 LADAGDLsRLIKHFKKqkrLIPERTIwkyfVQLCS----ALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLgrffSS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATiakrKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmfdlhpmralFLMSKSN----FQ--- 236
Cdd:cd08224 157 KTTAA----HSLVGTPYYMSPERI---REQGYDFKSDIWSLGCLLYEMAALQSP----------FYGEKMNlyslCKkie 219
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 237 ----PPKLKDktKWSSTFHNFVKIALTKNPKKRPTA 268
Cdd:cd08224 220 kceyPPLPAD--LYSQELRDLVAACIQPDPEKRPDI 253
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
19-279 2.83e-35

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 135.63  E-value: 2.83e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQ-EIFMvkECKHC-NIVAYFGSYLSREKLWICM 94
Cdd:cd06617   2 DLEVIEELGRGAYGVVDKMRHVPTGTIMAVKRIRatVNSQEQKRLLMDlDISM--RSVDCpYTVTFYGALFREGDVWICM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGgSLQDIY-HVTGP---LSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd06617  80 EVMDT-SLDKFYkKVYDKgltIPEDILGKIAVSIVKALEYLHSKLSvIHRDVKPSNVLINRNGQVKLCDFGISGYLVDSV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYwMAPEVAAVEKNG-GYNQLCDIWAVGITAIELGELQPPMFDLHPMralFLMSKSNFQ--PPKLKdKTKW 246
Cdd:cd06617 159 AKTIDAGCKPY-MAPERINPELNQkGYDVKSDVWSLGITMIELATGRFPYDSWKTP---FQQLKQVVEepSPQLP-AEKF 233
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06617 234 SPEFQDFVNKCLKKNYKERPNYPELLQHPFFEL 266
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
20-277 6.51e-35

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 133.71  E-value: 6.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL------EPGDdfslIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd08221   2 YIPVRVLGRGAFGEAVLYRKTEDNSLVVWKEVNLsrlsekERRD----ALNEIDILSLLNHDNIITYYNHFLDGESLFIE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQD-IYHVTGPL-SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd08221  78 MEYCNGGNLHDkIAQQKNQLfPEEVVLWYLYQIVSAVSHIHKAGILHRDIKTLNIFLTKADLVKLGDFGISKVLDSESSM 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQppklKDKTKWSSTFH 251
Cdd:cd08221 158 AESIVGTPYYMSPELVQGVK---YNFKSDIWAVGCVLYELLTLKRTFDATNPLRLAVKIVQGEYE----DIDEQYSEEII 230
                       250       260
                ....*....|....*....|....*.
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08221 231 QLVHDCLHQDPEDRPTAEELLERPLL 256
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
19-276 1.91e-34

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 132.80  E-value: 1.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII----KLEpgddfslIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14010   1 NYVLYDEIGRGKHSVVYKGRRKGTIEFVAIKCVdkskRPE-------VLNEVRLTHELKHPNVLKFYEWYETSNHLWLVV 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA---- 170
Cdd:cd14010  74 EYCTGGDLETLLRQDGNLPESSVRKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLARREGEILKelfg 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 ------------KRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLmsKSNFQ 236
Cdd:cd14010 154 qfsdegnvnkvsKKQAKRGTPYYMAPELF---QGGVHSFASDLWALGCVLYEMFTGKPPFVaeSFTELVEKIL--NEDPP 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 237 PPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14010 229 PPPPKVSSKPSPDFKSLLKGLLEKDPAKRLSWDELVKHPF 268
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
20-266 2.06e-34

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 132.84  E-value: 2.06e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLSREK----LWICM 94
Cdd:cd13985   2 YQVTKQLGEGGFSYVYLAHDVNTGRRYALKRMYFNDEEQLRVAIKEIEIMKRlCGHPNIVQYYDSAILSSEgrkeVLLLM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGgSLQDIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTDHGDVKLADFGVAAKItATIA 170
Cdd:cd13985  82 EYCPG-SLVDILEKSppSPLSEEEVLRIFYQICQAVGHLHSQSPpiIHRDIKIENILFSNTGRFKLCDFGSATTE-HYPL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIG----------TPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLmsksNFqppKL 240
Cdd:cd13985 160 ERAEEVNiieeeiqkntTPMYRAPEMIDLYSKKPIGEKADIWALGCLLYKLCFFKLPFDESSKLAIVAG----KY---SI 232
                       250       260
                ....*....|....*....|....*.
gi 38570135 241 KDKTKWSSTFHNFVKIALTKNPKKRP 266
Cdd:cd13985 233 PEQPRYSPELHDLIRHMLTPDPAERP 258
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
26-277 7.30e-34

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 131.72  E-value: 7.30e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQ--QEIFMVKECKHC-NIVAYFGSYLSREKLWICMEYCGGgSL 102
Cdd:cd06616  14 IGRGAFGTVNKMLHKPSGTIMAVKRIRST-VDEKEQKRllMDLDVVMRSSDCpYIVKFYGALFREGDCWICMELMDI-SL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIY-----HVTGPLSELQIAYVCRETLQGLAYLHTKGKM-HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd06616  92 DKFYkyvyeVLDSVIPEEILGKIAVATVKALNYLKEELKIiHRDVKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDAG 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYwMAPE-VAAVEKNGGYNQLCDIWAVGITAIEL--GELQPPMFDlhpmrALF--LMSKSNFQPPKLK--DKTKWSST 249
Cdd:cd06616 172 CRPY-MAPErIDPSASRDGYDVRSDVWSLGITLYEVatGKFPYPKWN-----SVFdqLTQVVKGDPPILSnsEEREFSPS 245
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd06616 246 FVNFVNLCLIKDESKRPKYKELLKHPFI 273
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
18-277 7.65e-34

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 130.59  E-value: 7.65e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14073   1 HRYELLETLGKGTYGKVKLAIERATGREVAIKSIkkdKIEDEQDMVRIRREIEIMSSLNHPHIIRIYEVFENKDKIVIVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKitatIAKRK- 173
Cdd:cd14073  81 EYASGGELYDYISERRRLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGLSNL----YSKDKl 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 --SFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLkdktkwsST 249
Cdd:cd14073 157 lqTFCGSPLYASPEI--VNGTPYQGPEVDCWSLGVLLYTLVYGTMP-FDGSDFKRLVkqISSGDYREPTQP-------SD 226
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14073 227 ASGLIRWMLTVNPKRRATIEDIANHWWV 254
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
21-272 1.20e-33

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 129.92  E-value: 1.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    21 ELVQRVGSGTYGDVYKAR----NVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:pfam07714   2 TLGEKLGEGAFGEVYKGTlkgeGENTKIKVAVKTLKEGADEEEREdFLEEASIMKKLDHPNIVKLLGVCTQGEPLYIVTE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    96 YCGGGSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:pfam07714  82 YMPGGDLLDFLRKhKRKLTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYYRKR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   175 FIG-TPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRALFLMsKSNFQPPKLKDktkWSSTFH 251
Cdd:pfam07714 162 GGGkLPIkWMAPESL---KDGKFTSKSDVWSFGVLLWEIFTLgEQPYPGMSNEEVLEFL-EDGYRLPQPEN---CPDELY 234
                         250       260
                  ....*....|....*....|.
gi 38570135   252 NFVKIALTKNPKKRPTAERLL 272
Cdd:pfam07714 235 DLMKQCWAYDPEDRPTFSELV 255
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
19-277 1.27e-33

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 129.85  E-value: 1.27e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd08220   1 KYEKIRVVGRGAYGTVYLCRRKDDNKLVIIKQIPVEqmTKEERQAALNEVKVLSMLHHPNIIEYYESFLEDKALMIVMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD-VKLADFGVaAKITATIAKRK 173
Cdd:cd08220  81 APGGTLFEYIQQRKGslLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNKKRTvVKIGDFGI-SKILSSKSKAY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQPPklkdKTKWSSTFHN 252
Cdd:cd08220 160 TVVGTPCYISPELC---EGKPYNQKSDIWALGCVLYELASLKRA-FEAANLPALVLkIMRGTFAPI----SDRYSEELRH 231
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08220 232 LILSMLHLDPNKRPTLSEIMAQPII 256
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
20-274 2.00e-33

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 129.37  E-value: 2.00e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDfsLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14095   2 YDIGRVIGDGNFAVVKECRDKATDKEYALKIIdkaKCKGKEH--MIENEVAILRRVKHPNIVQLIEEYDTDTELYLVMEL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKITATIAkr 172
Cdd:cd14095  80 VKGGDLFDAITSSTKFTERDASRMVTDLAQALKYLHSLSIVHRDIKPENLLVVEHEDgsksLKLADFGLATEVKEPLF-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVAAvEKngGYNQLCDIWAVG-ITAIEL---------GELQPPMFDlhpmraLFLMSKSNFQPPKLkD 242
Cdd:cd14095 158 -TVCGTPTYVAPEILA-ET--GYGLKVDIWAAGvITYILLcgfppfrspDRDQEELFD------LILAGEFEFLSPYW-D 226
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 243 KTKWSStfHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14095 227 NISDSA--KDLISRMLVVDPEKRYSAGQVLDH 256
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
19-274 4.15e-33

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 128.27  E-value: 4.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpgddFSLIQQEIFMVKECK-------HCNIVAYFGSYLSREKLW 91
Cdd:cd13997   1 HFHELEQIGSGSFSEVFKVRSKVDGCLYAVKKSKKP----FRGPKERARALREVEahaalgqHPNIVRYYSSWEEGGHLY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGP---LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd13997  77 IQMELCENGSLQDALEELSPiskLSEAEVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLETS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKsfiGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPpmfdLHPMRALFLMSKSNFQPPKLKDktKWSS 248
Cdd:cd13997 157 GDVEE---GDSRYLAPEL--LNENYTHLPKADIFSLGVTVYEAATGEP----LPRNGQQWQQLRQGKLPLPPGL--VLSQ 225
                       250       260
                ....*....|....*....|....*.
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd13997 226 ELTRLLKVMLDPDPTRRPTADQLLAH 251
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
20-277 5.49e-33

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 128.31  E-value: 5.49e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNV---HTGELAAVKII---KLEPgDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd08222   2 YRVVRKLGSGNFGTVYLVSDLkatADEELKVLKEIsvgELQP-DETVDANREAKLLSKLDHPAIVKFHDSFVEKESFCIV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSL----QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDhGDVKLADFGVAAKITATI 169
Cdd:cd08222  81 TEYCEGGDLddkiSEYKKSGTTIDENQILDWFIQLLLAVQYMHERRILHRDLKAKNIFLKN-NVIKVGDFGISRILMGTS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALfLMSKSNFQPPKLKDktKWSST 249
Cdd:cd08222 160 DLATTFTGTPYYMSPEVL---KHEGYNSKSDIWSLGCILYEMCCLKHA-FDGQNLLSV-MYKIVEGETPSLPD--KYSKE 232
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08222 233 LNAIYSRMLNKDPALRPSAAEILKIPFI 260
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
26-265 6.19e-33

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 128.11  E-value: 6.19e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05572   1 LGVGGFGRVELVQLKSKGRTFALKCVKKRHIVQTRQqehIFSEKEILEECNSPFIVKLYRTFKDKKYLYMLMEYCLGGEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKItATIAKRKSFIGTPYWM 182
Cdd:cd05572  81 WTILRDRGLFDEYTARFYTACVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKL-GSGRKTWTFCGTPEYV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 183 APEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmF---DLHPMRA--LFLMSKSNFQPPKLKDKtkwssTFHNFVKIA 257
Cdd:cd05572 160 APEII---LNKGYDFSVDYWSLGILLYELLTGRPP-FggdDEDPMKIynIILKGIDKIEFPKYIDK-----NAKNLIKQL 230

                ....*...
gi 38570135 258 LTKNPKKR 265
Cdd:cd05572 231 LRRNPEER 238
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
19-277 9.41e-33

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 127.55  E-value: 9.41e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS--LIQQEIFMVKECKHCNIVAYFGSYLSREK-LWICME 95
Cdd:cd08223   1 EYQFLRVIGKGSYGEVWLVRHKRDRKQYVIKKLNLKNASKRErkAAEQEAKLLSKLKHPNIVSYKESFEGEDGfLYIVMG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGslqDIYHVTG-----PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd08223  81 FCEGG---DLYTRLKeqkgvLLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARVLESSSD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDktkWSSTF 250
Cdd:cd08223 158 MATTLIGTPYYMSPELFS---NKPYNHKSDVWALGCCVYEMATLKHA-FNAKDMNSLVYKILEGKLPPMPKQ---YSPEL 230
                       250       260
                ....*....|....*....|....*..
gi 38570135 251 HNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd08223 231 GELIKAMLHQDPEKRPSVKRILRQPYI 257
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
20-277 1.39e-32

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 127.78  E-value: 1.39e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD---FSLIQqEIFMVKE---CKHCNIVAYF----GSYLSRE- 88
Cdd:cd07838   1 YEEVAEIGEGAYGTVYKARDLQDGRFVALKKVRVPLSEEgipLSTIR-EIALLKQlesFEHPNVVRLLdvchGPRTDREl 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGggslQDI-----YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd07838  80 KLTLVFEHVD----QDLatyldKCPKPGLPPETIKDLMRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLAR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAkRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPpMF----DLHPMRALF----------- 228
Cdd:cd07838 156 IYSFEMA-LTSVVVTLWYRAPEVLL---QSSYATPVDMWSVGCIFAELFNRRP-LFrgssEADQLGKIFdviglpseeew 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 229 ----LMSKSNF----QPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd07838 231 prnsALPRSSFpsytPRPFKSFVPEIDEEGLDLLKKMLTFNPHKRISAFEALQHPYF 287
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
26-274 2.84e-32

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 126.28  E-value: 2.84e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIklePGDDFSLIQQEIfmvKEC-KHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd13995  12 IPRGAFGKVYLAQDTKTKKRMACKLI---PVEQFKPSDVEI---QACfRHENIAELYGALLWEETVHLFMEAGEGGSVLE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVkLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Cdd:cd13995  86 KLESCGPMREFEIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYVPKDLRGTEIYMSP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 185 EVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRA----LFLMSKsnfQPPKLKD-KTKWSSTFHNFVKIALT 259
Cdd:cd13995 165 EVILCR---GHNTKADIYSLGATIIHMQTGSPPWVRRYPRSAypsyLYIIHK---QAPPLEDiAQDCSPAMRELLEAALE 238
                       250
                ....*....|....*
gi 38570135 260 KNPKKRPTAERLLTH 274
Cdd:cd13995 239 RNPNHRSSAAELLKH 253
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
28-268 6.06e-32

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 125.79  E-value: 6.06e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  28 SGTYGDVYKARNVHTGELAAVKIIKlepGDDFS--------LIQQEIFMvkECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05579   3 RGAYGRVYLAKKKSTGDLYAIKVIK---KRDMIrknqvdsvLAERNILS--QAQNPFVVKLYYSFQGKKNLYLVMEYLPG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG---------------VAAK 164
Cdd:cd05579  78 GDLYSLLENVGALDEDVARIYIAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGlskvglvrrqiklsiQKKS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMrALFL-MSKSNFQPPKLKDK 243
Cdd:cd05579 158 NGAPEKEDRRIVGTPDYLAPEIL---LGQGHGKTVDWWSLGVILYEFLVGIPPFHAETPE-EIFQnILNGKIEWPEDPEV 233
                       250       260
                ....*....|....*....|....*
gi 38570135 244 tkwSSTFHNFVKIALTKNPKKRPTA 268
Cdd:cd05579 234 ---SDEAKDLISKLLTPDPEKRLGA 255
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
26-276 6.51e-32

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 125.03  E-value: 6.51e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14009   1 IGRGSFATVWKGRHKQTGEVVAIKEISRKKLNKKLQenLESEIAILKSIKHPNIVRLYDVQKTEDFIYLVLEYCAGGDLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKI-TATIAkrKSFIGTP 179
Cdd:cd14009  81 QYIRKRGRLPEAVARHFMQQLASGLKFLRSKNIIHRDLKPQNLLLSTSGDdpvLKIADFGFARSLqPASMA--ETLCGSP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 180 YWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALT 259
Cdd:cd14009 159 LYMAPEILQFQK---YDAKADLWSVGAILFEMLVGKPP-FRGSNHVQLLRNIERSDAVIPFPIAAQLSPDCKDLLRRLLR 234
                       250
                ....*....|....*..
gi 38570135 260 KNPKKRPTAERLLTHTF 276
Cdd:cd14009 235 RDPAERISFEEFFAHPF 251
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
26-271 7.01e-32

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 124.86  E-value: 7.01e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnvHTGELAAVKIIKLEpgDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14058   1 VGRGSFGVVCKAR--WRNQIVAVKIIESE--SEKKAFEVEVRQLSRVDHPNIIKLYGACSNQKPVCLVMEYAEGGSLYNV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YHVTGPLSELQIAYV---CRETLQGLAYLHT---KGKMHRDIKGANILLTDHG-DVKLADFGVAAKITATIAKRKsfiGT 178
Cdd:cd14058  77 LHGKEPKPIYTAAHAmswALQCAKGVAYLHSmkpKALIHRDLKPPNLLLTNGGtVLKICDFGTACDISTHMTNNK---GS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDL-HPMRALFLMSKSNFQPPKLKDKTKwssTFHNFVKIA 257
Cdd:cd14058 154 AAWMAPEVF---EGSKYSEKCDVFSWGIILWEVITRRKPFDHIgGPAFRIMWAVHNGERPPLIKNCPK---PIESLMTRC 227
                       250
                ....*....|....
gi 38570135 258 LTKNPKKRPTAERL 271
Cdd:cd14058 228 WSKDPEKRPSMKEI 241
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
18-280 7.93e-32

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 125.41  E-value: 7.93e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIklepgdDFSLIQQE-----IFMVKE----CKHCNIVAYFGSYLSRE 88
Cdd:cd05581   1 NDFKFGKPLGEGSYSTVVLAKEKETGKEYAIKVL------DKRHIIKEkkvkyVTIEKEvlsrLAHPGIVKLYYTFQDES 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKIT-- 166
Cdd:cd05581  75 KLYFVLEYAPNGDLLEYIRKYGSLDEKCTRFYTAEIVLALEYLHSKGIIHRDLKPENILLDEDMHIKITDFG-TAKVLgp 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ----------------ATIAKRKSFIGTPYWMAPEVAAvEKNGGYNqlCDIWAVGITAIElgelqppMF-DLHPMRAlfl 229
Cdd:cd05581 154 dsspestkgdadsqiaYNQARAASFVGTAEYVSPELLN-EKPAGKS--SDLWALGCIIYQ-------MLtGKPPFRG--- 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 38570135 230 msKSNFQppklkdktkwssTFHNFVKIALTKNPKKRPTAERLLTHTFVAQP 280
Cdd:cd05581 221 --SNEYL------------TFQKIVKLEYEFPENFPPDAKDLIQKLLVLDP 257
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
26-277 1.79e-31

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 124.39  E-value: 1.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII---KL--------------------EPGDDFSLIQQEIFMVKECKHCNIVAYFg 82
Cdd:cd14118   2 IGKGSYGIVKLAYNEEDNTLYAMKILskkKLlkqagffrrppprrkpgalgKPLDPLDRVYREIAILKKLDHPNVVKLV- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  83 SYL---SREKLWICMEYCGGGSLQDIyHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159
Cdd:cd14118  81 EVLddpNEDNLYMVFELVDKGAVMEV-PTDNPLSEETARSYFRDIVLGIEYLHYQKIIHRDIKPSNLLLGDDGHVKIADF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 160 GVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRalfLMSKSNFQPPK 239
Cdd:cd14118 160 GVSNEFEGDDALLSSTAGTPAFMAPEALSESRKKFSGKALDIWAMGVTLYCFVFGRCPFEDDHILG---LHEKIKTDPVV 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14118 237 FPDDPVVSEQLKDLILRMLDKNPSERITLPEIKEHPWV 274
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
18-279 1.88e-31

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 125.93  E-value: 1.88e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd06649   5 DDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEikPAIRNQIIR-ELQVLHECNSPYIVGFYGAFYSDGEISICME 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLTDHGDVKLADFGVAAKITATIAkrKS 174
Cdd:cd06649  84 HMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQiMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELG------------ELQ-----------------------PP-- 217
Cdd:cd06649 162 FVGTRSYMSPERL---QGTHYSVQSDIWSMGLSLVELAigrypipppdakELEaifgrpvvdgeegephsisprprPPgr 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 218 -----MFDLHPMRALF--LMSKSNFQPPKLKDKTkWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd06649 239 pvsghGMDSRPAMAIFelLDYIVNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLMNHTFIKR 306
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
19-274 2.66e-31

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 123.28  E-value: 2.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14663   1 RYELGRTLGEGTFAKVKFARNTKTGESVAIKIIDKEQVAREGMVEQikrEIAIMKLLRHPNIVELHEVMATKTKIFFVME 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA--KITATIAKRK 173
Cdd:cd14663  81 LVTGGELFSKIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLSAlsEQFRQDGLLH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVG-ITAIELGELQPpmFDLHPMRALFL-MSKSNFQPPklkdktKWSST-F 250
Cdd:cd14663 161 TTCGTPNYVAPEV--LARRGYDGAKADIWSCGvILFVLLAGYLP--FDDENLMALYRkIMKGEFEYP------RWFSPgA 230
                       250       260
                ....*....|....*....|....
gi 38570135 251 HNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14663 231 KSLIKRILDPNPSTRITVEQIMAS 254
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
21-272 3.59e-31

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 123.02  E-value: 3.59e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     21 ELVQRVGSGTYGDVYKAR----NVHTGELAAVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:smart00219   2 TLGKKLGEGAFGEVYKGKlkgkGGKKKVEVAVKTLKEDASEqQIEEFLREARIMRKLDHPNVVKLLGVCTEEEPLYIVME 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     96 YCGGGSLQD---IYHVTGPLSEL-----QIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:smart00219  82 YMEGGDLLSylrKNRPKLSLSDLlsfalQIA-------RGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYD 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    168 TIAKRKSFIGTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRALFLMSKSNF--QPPKLKDK 243
Cdd:smart00219 155 DDYYRKRGGKLPIrWMAPESL---KEGKFTSKSDVWSFGVLLWEIFTLgEQPYPGMSNEEVLEYLKNGYRlpQPPNCPPE 231
                          250       260
                   ....*....|....*....|....*....
gi 38570135    244 tkwsstFHNFVKIALTKNPKKRPTAERLL 272
Cdd:smart00219 232 ------LYDLMLQCWAEDPEDRPTFSELV 254
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
20-276 3.66e-31

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 123.64  E-value: 3.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIkLEPGDDfSLIQQ----EIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07847   3 YEKLSKIGEGSYGVVFKCRNRETGQIVAIKKF-VESEDD-PVIKKialrEIRMLKQLKHPNLVNLIEVFRRKRKLHLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd07847  81 YCDHTVLNELEKNPRGVPEHLIKKIIWQTLQAVNFCHKHNCIHRDVKPENILITKQGQIKLCDFGFARILTGPGDDYTDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPE--VAAVEknggYNQLCDIWAVGITAIE-----------------------LGELQPPMFDL----HPMRA 226
Cdd:cd07847 161 VATRWYRAPEllVGDTQ----YGPPVDVWAIGCVFAElltgqplwpgksdvdqlylirktLGDLIPRHQQIfstnQFFKG 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 38570135 227 LFLMSKSNFQPpkLKDK-TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07847 237 LSIPEPETREP--LESKfPNISSPALSFLKGCLQMDPTERLSCEELLEHPY 285
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
14-274 3.81e-31

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 123.23  E-value: 3.81e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQR-VGSGTYGDVYKARNVHTGELAAVKIIKL-EPGDDFSL-IQQEIFMVKECKHCN-IVAYFGSYLSREK 89
Cdd:cd14106   3 ENINEVYTVESTpLGRGKFAVVRKCIHKETGKEYAAKFLRKrRRGQDCRNeILHEIAVLELCKDCPrVVNLHEVYETRSE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---DHGDVKLADFGVAAKIT 166
Cdd:cd14106  83 LILILELAAGGELQTLLDEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLTsefPLGDIKLCDFGISRVIG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKsFIGTPYWMAPEVAAveknggYNQLC---DIWAVGI-TAIELGELQPpmFDLHPMRALFL-MSKSNFQ-PPKL 240
Cdd:cd14106 163 EGEEIRE-ILGTPDYVAPEILS------YEPISlatDMWSIGVlTYVLLTGHSP--FGGDDKQETFLnISQCNLDfPEEL 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 241 KDKTkwSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14106 234 FKDV--SPLAIDFIKRLLVKDPEKRLTAKECLEH 265
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
20-277 1.01e-30

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 121.59  E-value: 1.01e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14081   3 YRLGKTLGKGQTGLVKLAKHCVTGQKVAIKIVNKEKLSKESVlmkVEREIAIMKLIEHPNVLKLYDVYENKKYLYLVLEY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDiYHVT-GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAkITATIAKRKSF 175
Cdd:cd14081  83 VSGGELFD-YLVKkGRLTEKEARKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGMAS-LQPEGSLLETS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAVEKNGGynQLCDIWAVGIT--AIELGELqPpmFDLHPMRALFLMSKS------NFQPPKLKDktkws 247
Cdd:cd14081 161 CGSPHYACPEVIKGEKYDG--RKADIWSCGVIlyALLVGAL-P--FDDDNLRQLLEKVKRgvfhipHFISPDAQD----- 230
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 248 stfhnFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14081 231 -----LLRRMLEVNPEKRITIEEIKKHPWF 255
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
20-274 1.05e-30

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 121.91  E-value: 1.05e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKA--RNVHTGELAAVKII--KLEPgDDFslIQQ----EIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd14080   2 YRLGKTIGEGSYSKVKLAeyTKSGLKEKVACKIIdkKKAP-KDF--LEKflprELEILRKLRHPNIIQVYSIFERGSKVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd14080  79 IFMEYAEHGDLLEYIQKRGALSESQARIWFRQLALAVQYLHSLDIAHRDLKCENILLDSNNNVKLSDFGFARLCPDDDGD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKS--FIGTPYWMAPEVAaveKNGGYN-QLCDIWAVG-ITAIELGELQPpmFDLHPMRALF---LMSKSNFQPpklkDKT 244
Cdd:cd14080 159 VLSktFCGSAAYAAPEIL---QGIPYDpKKYDIWSLGvILYIMLCGSMP--FDDSNIKKMLkdqQNRKVRFPS----SVK 229
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14080 230 KLSPECKDLIDQLLEPDPTKRATIEEILNH 259
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
27-274 1.52e-30

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 120.84  E-value: 1.52e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIY 106
Cdd:cd14006   2 GRGRFGVVKRCIEKATGREFAAKFIPKRDKKK-EAVLREISILNQLQHPRIIQLHEAYESPTELVLILELCSGGELLDRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 107 HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG--DVKLADFGVAAKITATiAKRKSFIGTPYWMAP 184
Cdd:cd14006  81 AERGSLSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLADRPspQIKIIDFGLARKLNPG-EELKEIFGTPEFVAP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 185 EVAAVEKNGGYNqlcDIWAVGITA-IELGELQPpmfdlhpmralFL----------MSKSNFqppklkdktKWSSTFHN- 252
Cdd:cd14006 160 EIVNGEPVSLAT---DMWSIGVLTyVLLSGLSP-----------FLgeddqetlanISACRV---------DFSEEYFSs 216
                       250       260
                ....*....|....*....|....*....
gi 38570135 253 -------FVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14006 217 vsqeakdFIRKLLVKEPRKRPTAQEALQH 245
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
26-276 2.01e-30

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 120.79  E-value: 2.01e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTG-ELA--AVKIIKLEPgDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM--EYCGGG 100
Cdd:cd13983   9 LGRGSFKTVYRAFDTEEGiEVAwnEIKLRKLPK-AERQRFKQEIEILKSLKHPNIIKFYDSWESKSKKEVIFitELMTSG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLT-DHGDVKLADFGVAAKITATiaKRKSFIG 177
Cdd:cd13983  88 TLKQYLKRFKRLKLKVIKSWCRQILEGLNYLHTRDPpiIHRDLKCDNIFINgNTGEVKIGDLGLATLLRQS--FAKSVIG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAavekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLkDKTKwSSTFHNFVKIA 257
Cdd:cd13983 166 TPEFMAPEMY----EEHYDEKVDIYAFGMCLLEMATGEYPYSECTNAAQIYKKVTSGIKPESL-SKVK-DPELKDFIEKC 239
                       250
                ....*....|....*....
gi 38570135 258 LTKnPKKRPTAERLLTHTF 276
Cdd:cd13983 240 LKP-PDERPSARELLEHPF 257
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
18-265 2.11e-30

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 121.53  E-value: 2.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgddfsliQQEIFMVKECKHCN-------------IVAYFGSY 84
Cdd:cd05580   1 DDFEFLKTLGTGSFGRVRLVKHKDSGKYYALKILK----------KAKIIKLKQVEHVLnekrilsevrhpfIVNLLGSF 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd05580  71 QDDRNLYMVMEYVPGGELFSLLRRSGRFPNDVAKFYAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKR 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 I---TATIAkrksfiGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLK 241
Cdd:cd05580 151 VkdrTYTLC------GTPEYLAPEII---LSKGHGKAVDWWALGILIYEMLAGYPPFFDENPMKIYEKILEGKIRFPSFF 221
                       250       260
                ....*....|....*....|....
gi 38570135 242 DKTKwsstfHNFVKIALTKNPKKR 265
Cdd:cd05580 222 DPDA-----KDLIKRLLVVDLTKR 240
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
21-267 2.22e-30

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 120.73  E-value: 2.22e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     21 ELVQRVGSGTYGDVYKAR----NVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:smart00221   2 TLGKKLGEGAFGEVYKGTlkgkGDGKEVEVAVKTLKEDASEQqIEEFLREARIMRKLDHPNIVKLLGVCTEEEPLMIVME 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135     96 YCGGGSLQDIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:smart00221  82 YMPGGDLLDYLRKNRPkeLSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYKV 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    174 SFIGTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIE---LGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKtkwsst 249
Cdd:smart00221 162 KGGKLPIrWMAPESL---KEGKFTSKSDVWSFGVLLWEiftLGEEPYPGMSNAEVLEYLKKGYRLPKPPNCPPE------ 232
                          250
                   ....*....|....*...
gi 38570135    250 FHNFVKIALTKNPKKRPT 267
Cdd:smart00221 233 LYKLMLQCWAEDPEDRPT 250
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
20-277 2.31e-30

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 120.44  E-value: 2.31e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNvHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14161   5 YEFLETLGKGTYGRVKKARD-SSGRLVAIKSIrkdRIKDEQDLLHIRREIEIMSSLNHPHIISVYEVFENSSKIVIVMEY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAKRKSFI 176
Cdd:cd14161  84 ASRGDLYDYISERQRLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGL-SNLYNQDKFLQTYC 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNqlCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLKDKTkwsstfhNFV 254
Cdd:cd14161 163 GSPLYASPEIVNGRPYIGPE--VDSWSLGVLLYILVHGTMP-FDGHDYKILVkqISSGAYREPTKPSDAC-------GLI 232
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14161 233 RWLLMVNPERRATLEDVASHWWV 255
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
18-275 2.32e-30

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 120.49  E-value: 2.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIFMVKECK-------HCNIVAYFGSYLSREKL 90
Cdd:cd14050   1 QCFTILSKLGEGSFGEVFKVRSREDGKLYAVKRSR----SRFRGEKDRKRKLEEVErheklgeHPNCVRFIKAWEEKGIL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGgSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd14050  77 YIQTELCDT-SLQQYCEETHSLPESEVWNILLDLLKGLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGLVVELDKEDI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSfIGTPYWMAPEVAavekNGGYNQLCDIWAVGITAIELG-ELQPPMF--DLHPMRALFLmsksnfqPPKLKDKTkwS 247
Cdd:cd14050 156 HDAQ-EGDPRYMAPELL----QGSFTKAADIFSLGITILELAcNLELPSGgdGWHQLRQGYL-------PEEFTAGL--S 221
                       250       260
                ....*....|....*....|....*...
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHT 275
Cdd:cd14050 222 PELRSIIKLMMDPDPERRPTAEDLLALP 249
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
17-278 2.32e-30

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 121.64  E-value: 2.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14166   2 RETFIFMEVLGSGAFSEVYLVKQRSTGKLYALKCIKKSPLSRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGAN-----------ILLTDHGDVKLADFGVAAki 165
Cdd:cd14166  82 VSGGELFDRILERGVYTEKDASRVINQVLSAVKYLHENGIVHRDLKPENllyltpdenskIMITDFGLSKMEQNGIMS-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATiakrksfiGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRaLFLMSKS---NFQPPKLKD 242
Cdd:cd14166 160 TAC--------GTPGYVAPEVLAQKP---YSKAVDCWSIGVITYILLCGYPPFYEETESR-LFEKIKEgyyEFESPFWDD 227
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 243 ktkWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd14166 228 ---ISESAKDFIRHLLEKNPSKRYTCEKALSHPWII 260
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
19-276 4.03e-30

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 120.90  E-value: 4.03e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQqEIFMVKECK-HCNIVAYFGSYLSREKLWICM 94
Cdd:cd07832   1 RYKILGRIGEGAHGIVFKAKDRETGETVALKKValrKLEGGIPNQALR-EIKALQACQgHPYVVKLRDVFPHGTGFVLVF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd07832  80 EYMLSSLSEVLRDEERPLTEAQVKRYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGLARLFSEEDPRLYS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 F-IGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL--------GE------------LQPPMFDLHP-MRALFLMSK 232
Cdd:cd07832 160 HqVATRWYRAPELLYGSRK--YDEGVDLWAVGCIFAELlngsplfpGEndieqlaivlrtLGTPNEKTWPeLTSLPDYNK 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 233 SNF--QPPKLkdktkWSSTFHN-------FVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07832 238 ITFpeSKGIR-----LEEIFPDcspeaidLLKGLLVYNPKKRLSAEEALRHPY 285
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
20-281 4.83e-30

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 120.75  E-value: 4.83e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------GDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd07841   2 YEKGKKLGEGTYAVVYKARDKETGRIVAIKKIKLGErkeakdGINFTALR-EIKLLQELKHPNIIGLLDVFGHKSNINLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd07841  81 FEFMETDLEKVIKDKSIVLTPADIKSYMLMTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARSFGSPNRKMT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELgELQPPMF----DLHPMRALF--LMSKSNFQPP---KLKDKT 244
Cdd:cd07841 161 HQVVTRWYRAPELLFGARH--YGVGVDMWSVGCIFAEL-LLRVPFLpgdsDIDQLGKIFeaLGTPTEENWPgvtSLPDYV 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 245 KWSST----FHNFVKIA-----------LTKNPKKRPTAERLLTHT-FVAQPG 281
Cdd:cd07841 238 EFKPFpptpLKQIFPAAsddaldllqrlLTLNPNKRITARQALEHPyFSNDPA 290
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
20-276 1.03e-29

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 119.46  E-value: 1.03e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07839   2 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGvpSSALREICLLKELKHKNIVRLYDVLHSDKKLTLVFEYC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GggslQDIYHVTGPLSELQIAYVCR----ETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd07839  82 D----QDLKKYFDSCNGDIDPEIVKsfmfQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEKngGYNQLCDIWAVGITAIELGELQPPMF-----DLHPMRALFLMSKSNFQP-------PKLK 241
Cdd:cd07839 158 AEVVTLWYRPPDVLFGAK--LYSTSIDMWSAGCIFAELANAGRPLFpgndvDDQLKRIFRLLGTPTEESwpgvsklPDYK 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 242 D------KTKW-------SSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07839 236 PypmypaTTSLvnvvpklNSTGRDLLQNLLVCNPVQRISAEEALQHPY 283
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
20-277 1.04e-29

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 118.64  E-value: 1.04e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14078   5 YELHETIGSGGFAKVKLATHILTGEKVAIKIMdKKALGDDLPRVKTEIEALKNLSHQHICRLYHVIETDNKIFMVLEYCP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDiYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR-KSFI 176
Cdd:cd14078  85 GGELFD-YIVAKDrLSEDEARVFFRQIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGLCAKPKGGMDHHlETCC 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNqlCDIWAVGIT--AIELGELqPpmFDLHPMRALF-LMSKSNFQPPklkdktKW-SSTFHN 252
Cdd:cd14078 164 GSPAYAAPELIQGKPYIGSE--ADVWSMGVLlyALLCGFL-P--FDDDNVMALYrKIQSGKYEEP------EWlSPSSKL 232
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14078 233 LLDQMLQVDPKKRITVKELLNHPWV 257
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
17-278 1.07e-29

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 118.98  E-value: 1.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14167   2 RDIYDFREVLGTGAFSEVVLAEEKRTQKLVAIKCIakKALEGKETS-IENEIAVLHKIKHPNIVALDDIYESGGHLYLIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL---LTDHGDVKLADFGVaAKITATIAK 171
Cdd:cd14167  81 QLVSGGELFDRIVEKGFYTERDASKLIFQILDAVKYLHDMGIVHRDLKPENLLyysLDEDSKIMISDFGL-SKIEGSGSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRaLF---LMSKSNFQPPKLKDktkWSS 248
Cdd:cd14167 160 MSTACGTPGYVAPEVLAQKP---YSKAVDCWSIGVIAYILLCGYPPFYDENDAK-LFeqiLKAEYEFDSPYWDD---ISD 232
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd14167 233 SAKDFIQHLMEKDPEKRFTCEQALQHPWIA 262
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
26-272 1.18e-29

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 118.80  E-value: 1.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKAR---NVHTGELAAVKIIKlepgDDFSLIQQEIFMvKECK------HCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd00192   3 LGEGAFGEVYKGKlkgGDGKTVDVAVKTLK----EDASESERKDFL-KEARvmkklgHPNVVRLLGVCTEEEPLYLVMEY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQD---------IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd00192  78 MEGGDLLDflrksrpvfPSPEPSTLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSRDIYD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSfIGTP---YWMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRALFLMSKSNF--QPPKLK 241
Cdd:cd00192 158 DDYYRKK-TGGKlpiRWMAPESL---KDGIFTSKSDVWSFGVLLWEIFTLgATPYPGLSNEEVLEYLRKGYRlpKPENCP 233
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 242 DKtkwsstFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd00192 234 DE------LYELMLSCWQLDPEDRPTFSELV 258
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
26-276 1.26e-29

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 118.49  E-value: 1.26e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd14189   9 LGKGGFARCYEMTDLATNKTYAVKVIphsRVAKPHQREKIVNEIELHRDLHHKHVVKFSHHFEDAENIYIFLELCSRKSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWM 182
Cdd:cd14189  89 AHIWKARHTLLEPEVRYYLKQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARLEPPEQRKKTICGTPNYL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 183 APEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPklkdkTKWSSTFHNFVKIALTKNP 262
Cdd:cd14189 169 APEVLLRQ---GHGPESDVWSLGCVMYTLLCGNPPFETLDLKETYRCIKQVKYTLP-----ASLSLPARHLLAGILKRNP 240
                       250
                ....*....|....
gi 38570135 263 KKRPTAERLLTHTF 276
Cdd:cd14189 241 GDRLTLDQILEHEF 254
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
18-274 2.95e-29

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 117.59  E-value: 2.95e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIVAYFGSY------------- 84
Cdd:cd14047   6 QDFKEIELIGSGGFGQVFKAKHRIDGKTYAIKRVKLNN----EKAEREVKALAKLDHPNIVRYNGCWdgfdydpetsssn 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  85 ---LSREKLWICMEYCGGGSLQD-IYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159
Cdd:cd14047  82 ssrSKTKCLFIQMEFCEKGTLESwIEKRNGeKLDKVLALEIFEQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 160 GVAAKITATIAKRKSfIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELgelqppmfdLHPMRALFLMSK--SNFQP 237
Cdd:cd14047 162 GLVTSLKNDGKRTKS-KGTLSYMSPEQISSQD---YGKEVDIYALGLILFEL---------LHVCDSAFEKSKfwTDLRN 228
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 238 PKLKDK-TKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14047 229 GILPDIfDKRYKIEKTIIKKMLSKKPEDRPNASEILRT 266
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
20-274 3.15e-29

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 117.47  E-value: 3.15e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSLiQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14083   5 YEFKEVLGTGAFSEVVLAEDKATGKLVAIKCIdkKALKGKEDSL-ENEIAVLRKIKHPNIVQLLDIYESKSHLYLVMELV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITATIAkrKS 174
Cdd:cd14083  84 TGGELFDRIVEKGSYTEKDASHLIRQVLEAVDYLHSLGIVHRDLKPENLLYYSPDEdskIMISDFGLSKMEDSGVM--ST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMFDL--HPMRALFLMSKSNFQPPKLKDktkWSSTFHN 252
Cdd:cd14083 162 ACGTPGYVAPEVLAQK---PYGKAVDCWSIGVISYILLCGYPPFYDEndSKLFAQILKAEYEFDSPYWDD---ISDSAKD 235
                       250       260
                ....*....|....*....|..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14083 236 FIRHLMEKDPNKRYTCEQALEH 257
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
20-211 3.21e-29

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 117.97  E-value: 3.21e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL--EPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07836   2 FKQLEKLGEGTYATVYKGRNRTTGEIVALKEIHLdaEEGTPSTAIR-EISLMKELKHENIVRLHDVIHTENKLMLVFEYM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGG--SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd07836  81 DKDlkKYMDTHGVRGALDPNTVKSFTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFSNE 160
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 38570135 176 IGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL 211
Cdd:cd07836 161 VVTLWYRAPDVLLGSRT--YSTSIDIWSVGCIMAEM 194
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
18-265 1.01e-28

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 118.00  E-value: 1.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgddfsliQQEIFMVKECKHCN-------------IVAYFGSY 84
Cdd:PTZ00263  18 SDFEMGETLGTGSFGRVRIAKHKGTGEYYAIKCLK----------KREILKMKQVQHVAqeksilmelshpfIVNMMCSF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:PTZ00263  88 QDENRVYFLLEFVVGGELFTHLRKAGRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKK 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  165 ITatiAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDkt 244
Cdd:PTZ00263 168 VP---DRTFTLCGTPEYLAPEVI---QSKGHGKAVDWWTMGVLLYEFIAGYPPFFDDTPFRIYEKILAGRLKFPNWFD-- 239
                        250       260
                 ....*....|....*....|.
gi 38570135  245 kwsSTFHNFVKIALTKNPKKR 265
Cdd:PTZ00263 240 ---GRARDLVKGLLQTDHTKR 257
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
26-211 1.15e-28

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 115.57  E-value: 1.15e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTgelAAVKIIKL-EPG-DDFSLIQQEIFMVKECKHCNIVAYFGsYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14062   1 IGSGSFGTVYKGRWHGD---VAVKKLNVtDPTpSQLQAFKNEVAVLRKTRHVNILLFMG-YMTKPQLAIVTQWCEGSSLY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSEL-QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKRKS-------F 175
Cdd:cd14062  77 KHLHVLETKFEMlQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGL-----ATVKTRWSgsqqfeqP 151
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 38570135 176 IGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14062 152 TGSILWMAPEVIRMQDENPYSFQSDVYAFGIVLYEL 187
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
18-295 1.27e-28

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 116.75  E-value: 1.27e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14086   1 DEYDLKEELGKGAFSVVRRCVQKSTGQEFAAKIINTKklSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSL-QDIyhVTGPL-SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL---TDHGDVKLADFGVAAKITATIA 170
Cdd:cd14086  81 LVTGGELfEDI--VAREFySEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLaskSKGAAVKLADFGLAIEVQGDQQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFD--LHPMRALFLMSKSNFQPPklkdktKWSS 248
Cdd:cd14086 159 AWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDedQHRLYAQIKAGAYDYPSP------EWDT 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 249 TF---HNFVKIALTKNPKKRPTAERLLTHTFVAQ-----PGLSRALAVELLDKVN 295
Cdd:cd14086 230 VTpeaKDLINQMLTVNPAKRITAAEALKHPWICQrdrvaSMVHRQETVDCLKKFN 284
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
29-217 1.32e-28

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 115.66  E-value: 1.32e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  29 GTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLI-----QQEIFMVKECKHcNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd05611   7 GAFGSVYLAKKRSTGDYFAIKVLKKSDMIAKNQVtnvkaERAIMMIQGESP-YVAKLYYSFQSKDYLYLVMEYLNGGDCA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAKRKSFIGTPYWMA 183
Cdd:cd05611  86 SLIKTLGGLPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGL-SRNGLEKRHNKKFVGTPDYLA 164
                       170       180       190
                ....*....|....*....|....*....|....
gi 38570135 184 PEVaaVEKNGGyNQLCDIWAVGITAIELGELQPP 217
Cdd:cd05611 165 PET--ILGVGD-DKMSDWWSLGCVIFEFLFGYPP 195
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
20-265 1.45e-28

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 115.43  E-value: 1.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd05578   2 FQILRVIGKGSFGKVCIVQKKDTKKMFAMKYMnkqKCIEKDSVRNVLNELEILQELEHPFLVNLWYSFQDEEDMYMVVDL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQdiYHVT--GPLSELQIA-YVCrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRK 173
Cdd:cd05578  82 LLGGDLR--YHLQqkVKFSEETVKfYIC-EIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDG-TLAT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPmFDLHP------MRALFLmSKSNFQPPklkdktKWS 247
Cdd:cd05578 158 STSGTKPYMAPEVFMRA---GYSFAVDWWSLGVTAYEMLRGKRP-YEIHSrtsieeIRAKFE-TASVLYPA------GWS 226
                       250
                ....*....|....*...
gi 38570135 248 STFHNFVKIALTKNPKKR 265
Cdd:cd05578 227 EEAIDLINKLLERDPQKR 244
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
20-276 1.54e-28

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 115.91  E-value: 1.54e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL--------EPGDDFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKL 90
Cdd:cd14093   5 YEPKEILGRGVSSTVRRCIEKETGQEFAVKIIDItgekssenEAEELREATRREIEILRQVsGHPNIIELHDVFESPTFI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiA 170
Cdd:cd14093  85 FLVFELCRKGELFDYLTEVVTLSEKKTRRIMRQLFEAVEFLHSLNIVHRDLKPENILLDDNLNVKISDFGFATRLDEG-E 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVAAV---EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL-FLMS-KSNFQPPKLKDKtk 245
Cdd:cd14093 164 KLRELCGTPGYLAPEVLKCsmyDNAPGYGKEVDMWACGVIMYTLLAGCPPFWHRKQMVMLrNIMEgKYEFGSPEWDDI-- 241
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 246 wSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14093 242 -SDTAKDLISKLLVVDPKKRLTAEEALEHPF 271
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
18-276 1.65e-28

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 115.84  E-value: 1.65e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgDDFSLIQ---------QEIFMVKECK-HCNIVAYFGSYLSR 87
Cdd:cd14181  10 QKYDPKEVIGRGVSSVVRRCVHRHTGQEFAVKIIEVTA-ERLSPEQleevrsstlKEIHILRQVSgHPSIITLIDSYESS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd14181  89 TFIFLVFDLMRRGELFDYLTEKVTLSEKETRSIMRSLLEAVSYLHANNIVHRDLKPENILLDDQLHIKLSDFGFSCHLEP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TiAKRKSFIGTPYWMAPEV---AAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ--PPKLKD 242
Cdd:cd14181 169 G-EKLRELCGTPGYLAPEIlkcSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQMLMLRMIMEGRYQfsSPEWDD 247
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 243 KtkwSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14181 248 R---SSTVKDLISRLLVVDPEIRLTAEQALQHPF 278
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
20-277 2.61e-28

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 115.18  E-value: 2.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--------LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd14084   8 YIMSRTLGSGACGEVKLAYDKSTCKKVAIKIINkrkftigsRREINKPRNIETEIEILKKLSHPCIIKIEDFFDAEDDYY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVaAKITAT 168
Cdd:cd14084  88 IVLELMEGGELFDRVVSNKRLKEAICKLYFYQMLLAVKYLHSNGIIHRDLKPENVLLSSQEEeclIKITDFGL-SKILGE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVG-ITAIELGELQPpmFDLH----PMRALFLMSKSNFQPPKLKDK 243
Cdd:cd14084 167 TSLMKTLCGTPTYLAPEVLRSFGTEGYTRAVDCWSLGvILFICLSGYPP--FSEEytqmSLKEQILSGKYTFIPKAWKNV 244
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 244 tkwSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14084 245 ---SEEAKDLVKKMLVVDPSRRPSIEEALEHPWL 275
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
19-266 2.71e-28

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 114.91  E-value: 2.71e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKAR-NVHTGELAAVKIIKL----------EPGDDFSLIQQEIFMVKE-CKHCNIVAYFGSYLS 86
Cdd:cd08528   1 EYAVLELLGSGAFGCVYKVRkKSNGQTLLALKEINMtnpafgrteqERDKSVGDIISEVNIIKEqLRHPNIVRYYKTFLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLWICMEYCGGGSLQDIYHV----TGPLSELQIAYVCRETLQGLAYLHT-KGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd08528  81 NDRLYIVMELIEGAPLGEHFSSlkekNEHFTEDRIWNIFVQMVLALRYLHKeKQIVHRDLKPNNIMLGEDDKVTITDFGL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmfdLHPMRALFLMSK---SNFQP- 237
Cdd:cd08528 161 AKQKGPESSKMTSVVGTILYSCPEIV---QNEPYGEKADIWALGCILYQMCTLQPP---FYSTNMLTLATKiveAEYEPl 234
                       250       260
                ....*....|....*....|....*....
gi 38570135 238 PKLkdktKWSSTFHNFVKIALTKNPKKRP 266
Cdd:cd08528 235 PEG----MYSDDITFVIRSCLTPDPEARP 259
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
15-276 5.02e-28

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 114.91  E-value: 5.02e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIVAYFGSYLSREK----- 89
Cdd:cd14137   1 PVEISYTIEKVIGSGSFGVVYQAKLLETGEVVAIKKVLQDK----RYKNRELQIMRRLKHPNIVKLKYFFYSSGEkkdev 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 -LWICMEYCgGGSLQDIYH----VTGPLSELQI---AYvcrETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLADFG 160
Cdd:cd14137  77 yLNLVMEYM-PETLYRVIRhyskNKQTIPIIYVklySY---QLFRGLAYLHSLGICHRDIKPQNLLVdPETGVLKLCDFG 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 161 VAAKITATiAKRKSFIGTPYWMAPE--VAAVEknggYNQLCDIWAVG--ITAIELGElqpPMF----------------- 219
Cdd:cd14137 153 SAKRLVPG-EPNVSYICSRYYRAPEliFGATD----YTTAIDIWSAGcvLAELLLGQ---PLFpgessvdqlveiikvlg 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 220 -----DLHPMRAlflmSKSNFQPPKLKDKTkWSSTFHNFVK---IALTK-----NPKKRPTAERLLTHTF 276
Cdd:cd14137 225 tptreQIKAMNP----NYTEFKFPQIKPHP-WEKVFPKRTPpdaIDLLSkilvyNPSKRLTALEALAHPF 289
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
20-276 5.61e-28

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 114.44  E-value: 5.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIkLEPGDDF---SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd07846   3 YENLGLVGEGSYGMVMKCRHKETGQIVAIKKF-LESEDDKmvkKIAMREIKMLKQLRHENLVNLIEVFRRKKRWYLVFEF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd07846  82 VDHTVLDDLEKYPNGLDESRVRKYLFQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIE-----------------------LGELQP---PMFDLHPMRALFLM 230
Cdd:cd07846 162 ATRWYRAPEL--LVGDTKYGKAVDVWAVGCLVTEmltgeplfpgdsdidqlyhiikcLGNLIPrhqELFQKNPLFAGVRL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 231 SKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07846 240 PEVKEVEPLERRYPKLSGVVIDLAKKCLHIDPDKRPSCSELLHHEF 285
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
18-277 6.07e-28

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 113.42  E-value: 6.07e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14186   1 EDFKVLNLLGKGSFACVYRARSLHTGLEVAIKMIDKKAMQKAGMVQrvrNEVEIHCQLKHPSILELYNYFEDSNYVYLVL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd14186  81 EMCHNGEMSRyLKNRKKPFTEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEKNGGYNqlcDIWAVGITAIELGELQPPmFDLHPMR-ALFLMSKSNFQPPKLkdktkWSSTFHN 252
Cdd:cd14186 161 TMCGTPNYISPEIATRSAHGLES---DVWSLGCMFYTLLVGRPP-FDTDTVKnTLNKVVLADYEMPAF-----LSREAQD 231
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14186 232 LIHQLLRKNPADRLSLSSVLDHPFM 256
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
20-273 6.90e-28

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 113.60  E-value: 6.90e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVK-IIKLEP-GDDFSLIQQEIFM------VKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd13993   2 YQLISPIGEGAYGVVYLAVDLRTGRKYAIKcLYKSGPnSKDGNDFQKLPQLreidlhRRVSRHPNIITLHDVFETEVAIY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD-VKLADFGVAakITAT 168
Cdd:cd13993  82 IVLEYCPNGDLFEAITenRIYVGKTELIKNVFLQLIDAVKHCHSLGIYHRDIKPENILLSQDEGtVKLCDFGLA--TTEK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IaKRKSFIGTPYWMAPEVaaVEKNGGYNQLC-----DIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfQPPKLKDK 243
Cdd:cd13993 160 I-SMDFGVGSEFYMAPEC--FDEVGRSLKGYpcaagDIWSLGIILLNLTFGRNPWKIASESDPIFYDYYLN-SPNLFDVI 235
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 244 TKWSSTFHNFVKIALTKNPKKRPTAERLLT 273
Cdd:cd13993 236 LPMSDDFYNLLRQIFTVNPNNRILLPELQL 265
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
26-276 8.20e-28

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 113.18  E-value: 8.20e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd14188   9 LGKGGFAKCYEMTDLTTNKVYAAKIIphsRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWM 182
Cdd:cd14188  89 AHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAARLEPLEHRRRTICGTPNYL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 183 APEVAAVEKNGGYNqlcDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPklkdkTKWSSTFHNFVKIALTKNP 262
Cdd:cd14188 169 SPEVLNKQGHGCES---DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLP-----SSLLAPAKHLIASMLSKNP 240
                       250
                ....*....|....
gi 38570135 263 KKRPTAERLLTHTF 276
Cdd:cd14188 241 EDRPSLDEIIRHDF 254
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
20-277 1.46e-27

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 113.52  E-value: 1.46e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--------------------------LEPGDDFSLIQQEIFMVKECK 73
Cdd:cd14199   4 YKLKDEIGKGSYGVVKLAYNEDDNTYYAMKVLSkkklmrqagfprrppprgaraapegcTQPRGPIERVYQEIAILKKLD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  74 HCNIVAYFGSY--LSREKLWICMEYCGGGSLQDIyHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH 151
Cdd:cd14199  84 HPNVVKLVEVLddPSEDHLYMVFELVKQGPVMEV-PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDVKPSNLLVGED 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 152 GDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDlhpMRALFLMS 231
Cdd:cd14199 163 GHIKIADFGVSNEFEGSDALLTNTVGTPAFMAPETLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD---ERILSLHS 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 232 KSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14199 240 KIKTQPLEFPDQPDISDDLKDLLFRMLDKNPESRISVPEIKLHPWV 285
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
19-266 1.62e-27

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 112.81  E-value: 1.62e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKAR---NVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd08228   3 NFQIEKKIGRGQFSEVYRATcllDRKPVALKKVQIFEMMDAKARQDCVKEIDLLKQLNHPNVIKYLDSFIEDNELNIVLE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSL-QDIYHVTGP---LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd08228  83 LADAGDLsQMIKYFKKQkrlIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEvaAVEKNgGYNQLCDIWAVGITAIELGELQPPMFDlHPMRALFLMSK-SNFQPPKLKdKTKWSSTF 250
Cdd:cd08228 163 AHSLVGTPYYMSPE--RIHEN-GYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLFSLCQKiEQCDYPPLP-TEHYSEKL 237
                       250
                ....*....|....*.
gi 38570135 251 HNFVKIALTKNPKKRP 266
Cdd:cd08228 238 RELVSMCIYPDPDQRP 253
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
19-327 1.64e-27

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 114.33  E-value: 1.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIFMVKECKhcNIVAYFGS---------YLSREK 89
Cdd:cd05601   2 DFEVKNVIGRGHFGEVQVVKEKATGDIYAMKVLK----KSETLAQEEVSFFEEER--DIMAKANSpwitklqyaFQDSEN 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGG---SLQDIYHvtGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd05601  76 LYLVMEYHPGGdllSLLSRYD--DIFEESMARFYLAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGSAAKLS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 AT-IAKRKSFIGTPYWMAPEVAAV---EKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF-LMSKSNFQppKLK 241
Cdd:cd05601 154 SDkTVTSKMPVGTPDYIAPEVLTSmngGSKGTYGVECDWWSLGIVAYEMLYGKTPFTEDTVIKTYSnIMNFKKFL--KFP 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 242 DKTKWSSTFHNFVKIALTkNPKKRPTAERLLTHTFVAQPGLSRalaveLLDKVnnPDNHAHYTEADD----DDFEPHAII 317
Cdd:cd05601 232 EDPKVSESAVDLIKGLLT-DAKERLGYEGLCCHPFFSGIDWNN-----LRQTV--PPFVPTLTSDDDtsnfDEFEPKKTR 303
                       330
                ....*....|
gi 38570135 318 RHTIRSTNRN 327
Cdd:cd05601 304 PSYENFNKSK 313
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
26-206 2.49e-27

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 111.74  E-value: 2.49e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII-KLE-PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14082  11 LGSGQFGIVYGGKHRKTGRDVAIKVIdKLRfPTKQESQLRNEVAILQQLSHPGVVNLECMFETPERVFVVMEKLHGDMLE 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVaAKITATIAKRKSFIGTP 179
Cdd:cd14082  91 MILsSEKGRLPERITKFLVTQILVALRYLHSKNIVHCDLKPENVLLASAEPfpqVKLCDFGF-ARIIGEKSFRRSVVGTP 169
                       170       180
                ....*....|....*....|....*..
gi 38570135 180 YWMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd14082 170 AYLAPEVL---RNKGYNRSLDMWSVGV 193
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
19-274 2.88e-27

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 112.70  E-value: 2.88e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-F---SLiqQEIFMVKECKHCNIVAY----FGSYLsrEKL 90
Cdd:cd07843   6 EYEKLNRIEEGTYGVVYRARDKKTGEIVALKKLKMEKEKEgFpitSL--REINILLKLQHPNIVTVkevvVGSNL--DKI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGgSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd07843  82 YMVMEYVEH-DLKSLMeTMKQPFLQSEVKCLMLQLLSGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAREYGSPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGitAIeLGEL--QPPMF----DLHPMRALF--------------- 228
Cdd:cd07843 161 KPYTQLVVTLWYRAPELLLGAKE--YSTAIDMWSVG--CI-FAELltKKPLFpgksEIDQLNKIFkllgtptekiwpgfs 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 229 ---LMSKSNFQPP---KLKDK---TKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd07843 236 elpGAKKKTFTKYpynQLRKKfpaLSLSDNGFDLLNRLLTYDPAKRISAEDALKH 290
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
20-276 3.12e-27

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 111.58  E-value: 3.12e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDfsLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14185   2 YEIGRTIGDGNFAVVKECRHWNENQEYAMKIIdksKLKGKED--MIESEILIIKSLSHPNIVKLFEVYETEKEIYLILEY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKITATIAkr 172
Cdd:cd14185  80 VRGGDLFDAIIESVKFTEHDAALMIIDLCEALVYIHSKHIVHRDLKPENLLVQHNPDksttLKLADFGLAKYVTGPIF-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVAAvEKngGYNQLCDIWAVG-ITAIELGELQP---PMFDLHPMRALFLMSKSNFQPPklkdktKW-- 246
Cdd:cd14185 158 -TVCGTPTYVAPEILS-EK--GYGLEVDMWAAGvILYILLCGFPPfrsPERDQEELFQIIQLGHYEFLPP------YWdn 227
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 247 -SSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14185 228 iSEAAKDLISRLLVVDPEKRYTAKQVLQHPW 258
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
26-277 4.36e-27

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 111.26  E-value: 4.36e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARN--VHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14202  10 IGHGAFAVVFKGRHkeKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEIANSVYLVMEYCNGGDLA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---------VKLADFGVAAKITATIAKrKS 174
Cdd:cd14202  90 DYLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLSYSGGrksnpnnirIKIADFGFARYLQNNMMA-AT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTkwSSTFHNFV 254
Cdd:cd14202 169 LCGSPMYMAPEVIMSQH---YDAKADLWSIGTIIYQCLTGKAPFQASSPQDLRLFYEKNKSLSPNIPRET--SSHLRQLL 243
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14202 244 LGLLQRNQKDRMDFDEFFHHPFL 266
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
24-206 5.38e-27

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 110.84  E-value: 5.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKA-RNVHTGELAAVKII---KLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14121   1 EKLGSGTYATVYKAyRKSGAREVVAVKCVsksSLNKASTENLLT-EIELLKKLKHPHIVELKDFQWDEEHIYLIMEYCSG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSElqiaYVCRETLQGLA----YLHTKGKMHRDIKGANILLTDHGDV--KLADFGVAAKITATIAKRk 173
Cdd:cd14121  80 GDLSRFIRSRRTLPE----STVRRFLQQLAsalqFLREHNISHMDLKPQNLLLSSRYNPvlKLADFGFAQHLKPNDEAH- 154
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 174 SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGI 206
Cdd:cd14121 155 SLRGSPLYMAPEMIL---KKKYDARVDLWSVGV 184
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
15-278 5.75e-27

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 112.06  E-value: 5.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREKLWI 92
Cdd:cd14168   7 DIKKIFEFKEVLGTGAFSEVVLAEERATGKLFAVKCIpkKALKGKESS-IENEIAVLRKIKHENIVALEDIYESPNHLYL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL---TDHGDVKLADFGVaAKITATI 169
Cdd:cd14168  86 VMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYfsqDEESKIMISDFGL-SKMEGKG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL--FLMSKSNFQPPKLKDktkWS 247
Cdd:cd14168 165 DVMSTACGTPGYVAPEVLAQKP---YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFeqILKADYEFDSPYWDD---IS 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd14168 239 DSAKDFIRNLMEKDPNKRYTCEQALRHPWIA 269
PK_STRAD_alpha cd08227
Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain ...
21-279 7.06e-27

Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha, stabilized through ATP and MO25, may be needed to activate LKB1. A mutation which results in a truncation of a C-terminal part of the human STRAD-alpha pseudokinase domain and disrupts its association with LKB1, leads to PMSE (polyhydramnios, megalencephaly, symptomatic epilepsy) syndrome. Several splice variants of STRAD-alpha exist which exhibit different effects on the localization and activation of LKB1. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. The STRAD alpha subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173767 [Multi-domain]  Cd Length: 327  Bit Score: 112.34  E-value: 7.06e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGtYGD---VYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd08227   1 ELLTVIGRG-FEDlmtVNLARYKPTGEYVTVRRINLEacTNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLA---------DFGVAAK 164
Cdd:cd08227  80 FMAYGSAKDLIctHFMDGMSELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSglrsnlsmiNHGQRLR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKsfIGTPYWMAPEVaaVEKN-GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF---------LMSKSN 234
Cdd:cd08227 160 VVHDFPKYS--VKVLPWLSPEV--LQQNlQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLeklngtvpcLLDTTT 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 235 FQPPKLKDKTK--------------------------------WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd08227 236 IPAEELTMKPSrsgansglgesttvstprpsngessshpynrtFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQ 312
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
18-279 9.69e-27

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 110.77  E-value: 9.69e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ-QEI---------FMVKECKHCNIVAYFGSYLSR 87
Cdd:cd14182   3 EKYEPKEILGRGVSSVVRRCIHKPTRQEYAVKIIDITGGGSFSPEEvQELreatlkeidILRKVSGHPNIIQLKDTYETN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKItA 167
Cdd:cd14182  83 TFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL-D 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEV---AAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ--PPKLKD 242
Cdd:cd14182 162 PGEKLREVCGTPGYLAPEIiecSMDDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQfgSPEWDD 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 243 KtkwSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14182 242 R---SDTVKDLISRFLVVQPQKRYTAEEALAHPFFQQ 275
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
19-327 1.38e-26

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 111.99  E-value: 1.38e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgdDFSLIQQ-EIFMVKECK----HCN---IVAYFGSYLSREKL 90
Cdd:cd05573   2 DFEVIKVIGRGAFGEVWLVRDKDTGQVYAMKILR-----KSDMLKReQIAHVRAERdilaDADspwIVRLHYAFQDEDHL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGG---SLQDIYHVtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-- 165
Cdd:cd05573  77 YLVMEYMPGGdlmNLLIKYDV---FPEETARFYIAELVLALDSLHKLGFIHRDIKPDNILLDADGHIKLADFGLCTKMnk 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 --------------------TATIAKRK-------SFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPM 218
Cdd:cd05573 154 sgdresylndsvntlfqdnvLARRRPHKqrrvraySAVGTPDYIAPEVLRGT---GYGPECDWWSLGVILYEMLYGFPPF 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 219 FDLHPMRALF-LMS-KSNFQPPklkDKTKWSSTFHNFVKiALTKNPKKR-PTAERLLTHTFVAqpGL----SRALAVELL 291
Cdd:cd05573 231 YSDSLVETYSkIMNwKESLVFP---DDPDVSPEAIDLIR-RLLCDPEDRlGSAEEIKAHPFFK--GIdwenLRESPPPFV 304
                       330       340       350
                ....*....|....*....|....*....|....*.
gi 38570135 292 DKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRN 327
Cdd:cd05573 305 PELSSPTDTSNFDDFEDDLLLSEYLSNGSPLLGKGK 340
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
20-277 1.77e-26

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 109.56  E-value: 1.77e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS--LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14097   3 YTFGRKLGQGSFGVVIEATHKETQTKWAIKKINREKAGSSAvkLLEREVDILKHVNHAHIIHLEEVFETPKRMYLVMELC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-------TDHGDVKLADFGVAA-KITATI 169
Cdd:cd14097  83 EDGELKELLLRKGFFSENETRHIIQSLASAVAYLHKNDIVHRDLKLENILVkssiidnNDKLNIKVTDFGLSVqKYGLGE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQppklKDKTKW--- 246
Cdd:cd14097 163 DMLQETCGTPIYMAPEVIS---AHGYSQQCDIWSIGVIMYMLLCGEPPFVAKSEEKLFEEIRKGDLT----FTQSVWqsv 235
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14097 236 SDAAKNVLQQLLKVDPAHRMTASELLDNPWI 266
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
26-276 1.86e-26

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 109.38  E-value: 1.86e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNV-HTGELAAVKII-KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14120   1 IGHGAFAVVFKGRHRkKPDLPVAIKCItKKNLSKSQNLLGKEIKILKELSHENVVALLDCQETSSSVYLVMEYCNGGDLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---------VKLADFGVA-----AKITATI 169
Cdd:cd14120  81 DYLQAKGTLSEDTIRVFLQQIAAAMKALHSKGIVHRDLKPQNILLSHNSGrkpspndirLKIADFGFArflqdGMMAATL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AkrksfiGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELgelqppmfdlhpmralfLMSKSNFQ---PPKLK---DK 243
Cdd:cd14120 161 C------GSPMYMAPEVIMSLQ---YDAKADLWSIGTIVYQC-----------------LTGKAPFQaqtPQELKafyEK 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 38570135 244 TK---------WSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14120 215 NAnlrpnipsgTSPALKDLLLGLLKRNPKDRIDFEDFFSHPF 256
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
21-211 1.89e-26

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 109.72  E-value: 1.89e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDVYKARnvHTGELAaVKIIKL-EP-GDDFSLIQQEIFMVKECKHCNIVAYFGsYLSREKLWICMEYCG 98
Cdd:cd14150   3 SMLKRIGTGSFGTVFRGK--WHGDVA-VKILKVtEPtPEQLQAFKNEMQVLRKTRHVNILLFMG-FMTRPNFAIITQWCE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKRKSFI- 176
Cdd:cd14150  79 GSSLYRHLHVTETrFDTMQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL-----ATVKTRWSGSq 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 38570135 177 ------GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14150 154 qveqpsGSILWMAPEVIRMQDTNPYSFQSDVYAYGVVLYEL 194
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
16-272 1.92e-26

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 109.77  E-value: 1.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARnvHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGsYLSREKLWICM 94
Cdd:cd14151   6 PDGQITVGQRIGSGSFGTVYKGK--WHGDVAVKMLNVTAPTpQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSEL-QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKRK 173
Cdd:cd14151  83 QWCEGSSLYHHLHIIETKFEMiKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGL-----ATVKSRW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 S-------FIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPM-RALFLMSKSNFQPPKLKDKTK 245
Cdd:cd14151 158 SgshqfeqLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRdQIIFMVGRGYLSPDLSKVRSN 237
                       250       260
                ....*....|....*....|....*..
gi 38570135 246 WSSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd14151 238 CPKAMKRLMAECLKKKRDERPLFPQIL 264
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
20-211 2.09e-26

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 109.90  E-value: 2.09e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07860   2 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGvpSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GggslQDI--YHVTGPLSELQIAYV---CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd07860  82 H----QDLkkFMDASALTGIPLPLIksyLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY 157
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 38570135 173 KSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL 211
Cdd:cd07860 158 THEVVTLWYRAPEILLGCKY--YSTAVDIWSLGCIFAEM 194
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
20-277 2.50e-26

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 109.11  E-value: 2.50e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd14105   7 YDIGEELGSGQFAVVKKCREKSTGLEYAAKFIKKRRskasrrGVSREDIEREVSILRQVLHPNIITLHDVFENKTDVVLI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD----HGDVKLADFGVAAKITATi 169
Cdd:cd14105  87 LELVAGGELFDFLAEKESLSEEEATEFLKQILDGVNYLHTKNIAHFDLKPENIMLLDknvpIPRIKLIDFGLAHKIEDG- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGgynQLCDIWAVG-ITAIELGELQPPMFDLHpMRALFLMSKSNFQ-PPKLKDKTkwS 247
Cdd:cd14105 166 NEFKNIFGTPEFVAPEIVNYEPLG---LEADMWSIGvITYILLSGASPFLGDTK-QETLANITAVNYDfDDEYFSNT--S 239
                       250       260       270
                ....*....|....*....|....*....|
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14105 240 ELAKDFIRQLLVKDPRKRMTIQESLRHPWI 269
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
22-284 2.85e-26

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 109.35  E-value: 2.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKARnvHTGELAaVKIIKL-EPG-DDFSLIQQEIFMVKECKHCNIVAYFGsYLSREKLWICMEYCGG 99
Cdd:cd14149  16 LSTRIGSGSFGTVYKGK--WHGDVA-VKILKVvDPTpEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEG 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK--SFI 176
Cdd:cd14149  92 SSLYKHLHVqETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQveQPT 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPM-RALFLMSKSNFQPPKLKDKTKWSSTFHNFVK 255
Cdd:cd14149 172 GSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRdQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 251
                       250       260
                ....*....|....*....|....*....
gi 38570135 256 IALTKNPKKRPTAERLLTHTFVAQPGLSR 284
Cdd:cd14149 252 DCIKKVKEERPLFPQILSSIELLQHSLPK 280
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
20-206 3.43e-26

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 108.54  E-value: 3.43e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14162   2 YIVGKTLGHGSYAVVKKAYSTKHKCKVAIKIVsKKKAPEDYlqKFLPREIEVIKGLKHPNLICFYEAIETTSRVYIIMEL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR---- 172
Cdd:cd14162  82 AENGDLLDYIRKNGALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFARGVMKTKDGKpkls 161
                       170       180       190
                ....*....|....*....|....*....|....*
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYN-QLCDIWAVGI 206
Cdd:cd14162 162 ETYCGSYAYASPEIL---RGIPYDpFLSDIWSMGV 193
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
27-277 5.05e-26

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 108.11  E-value: 5.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLE-----PGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSRE--KLWICMEYCGG 99
Cdd:cd14119   2 GEGSYGKVKEVLDTETLCRRAVKILKKRklrriPNGEAN-VKREIQILRRLNHRNVIKLVDVLYNEEkqKLYMVMEYCVG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVtgPLSELQI----AYVCrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-------TAT 168
Cdd:cd14119  81 GLQEMLDSA--PDKRLPIwqahGYFV-QLIDGLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEALdlfaeddTCT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKrksfiGTPYWMAPEVAavekNG-----GYnqLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDK 243
Cdd:cd14119 158 TSQ-----GSPAFQPPEIA----NGqdsfsGF--KVDIWSAGVTLYNMTTGKYPFEGDNIYKLFENIGKGEYTIPDDVDP 226
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 244 tkwssTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14119 227 -----DLQDLLRGMLEKDPEKRFTIEQIRQHPWF 255
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
26-276 5.09e-26

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 108.10  E-value: 5.09e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLiQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd14187  15 LGKGGFAKCYEITDADTKEVFAGKIVPksllLKPHQKEKM-SMEIAIHRSLAHQHVVGFHGFFEDNDFVYVVLELCRRRS 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
Cdd:cd14187  94 LLELHKRRKALTEPEARYYLRQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGERKKTLCGTPNY 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 182 MAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSN-FQPPKlkdktKWSSTFHNFVKIALTK 260
Cdd:cd14187 174 IAPEVLSKK---GHSFEVDIWSIGCIMYTLLVGKPP-FETSCLKETYLRIKKNeYSIPK-----HINPVAASLIQKMLQT 244
                       250
                ....*....|....*.
gi 38570135 261 NPKKRPTAERLLTHTF 276
Cdd:cd14187 245 DPTARPTINELLNDEF 260
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
18-279 5.39e-26

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 110.09  E-value: 5.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKiiKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYF-----GSYLSREK 89
Cdd:cd07849   5 PRYQNLSYIGEGAYGMVCSAVHKPTGQKVAIK--KISPFEHQTYCLRtlrEIKILLRFKHENIIGILdiqrpPTFESFKD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGggslQDIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITA 167
Cdd:cd07849  83 VYIVQELME----TDLYKLikTQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGL-ARIAD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSF----IGTPYWMAPEVAAVEKngGYNQLCDIWAVGITAIELgELQPPMFD--------LHPMRALFLMSKSNF 235
Cdd:cd07849 158 PEHDHTGFlteyVATRWYRAPEIMLNSK--GYTKAIDIWSVGCILAEM-LSNRPLFPgkdylhqlNLILGILGTPSQEDL 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 236 QPPK------------LKDKTKWSSTFHN-------FVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd07849 235 NCIIslkarnyikslpFKPKVPWNKLFPNadpkaldLLDKMLTFNPHKRITVEEALAHPYLEQ 297
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
18-223 5.47e-26

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 109.06  E-value: 5.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05612   1 DDFERIKTIGTGTFGRVHLVRDRISEHYYALKVMAIPEVIRLKQEQHvhnEKRVLKEVSHPFIIRLFWTEHDQRFLYMLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKItatIAKRKS 174
Cdd:cd05612  81 EYVPGGELFSYLRNSGRFSNSTGLFYASEIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKL---RDRTWT 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 175 FIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHP 223
Cdd:cd05612 158 LCGTPEYLAPEVIQ---SKGHNKAVDWWALGILIYEMLVGYPPFFDDNP 203
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
19-276 7.40e-26

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 108.94  E-value: 7.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLI-QQEIFMVKECKHCNIV-----AYFGSYLSREKL- 90
Cdd:cd07866   9 DYEILGKLGEGTFGEVYKARQIKTGRVVALKkILMHNEKDGFPITaLREIKILKKLKHPNVVplidmAVERPDKSKRKRg 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 -------WICMEYCGGGSLQDIYhvtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd07866  89 svymvtpYMDHDLSGLLENPSVK-----LTESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLAR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIG-----------TPYWMAPEVAAVEKNggYNQLCDIWAVGITaieLGEL--QPPMF----DLHPMRA 226
Cdd:cd07866 164 PYDGPPPNPKGGGGggtrkytnlvvTRWYRPPELLLGERR--YTTAVDIWGIGCV---FAEMftRRPILqgksDIDQLHL 238
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135 227 LF-LM------SKSNFQ--------------PPKLKDK-TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07866 239 IFkLCgtpteeTWPGWRslpgcegvhsftnyPRTLEERfGKLGPEGLDLLSKLLSLDPYKRLTASDALEHPY 310
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
15-277 7.52e-26

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 107.80  E-value: 7.52e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSRE 88
Cdd:cd14194   2 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRtkssrrGVSREDIEREVSILKEIQHPNVITLHEVYENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD----HGDVKLADFGVAAK 164
Cdd:cd14194  82 DVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDrnvpKPRIKIIDFGLAHK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATiAKRKSFIGTPYWMAPEVAAVEKNGgynQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQppklKDKT 244
Cdd:cd14194 162 IDFG-NEFKNIFGTPEFVAPEIVNYEPLG---LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYE----FEDE 233
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 245 KWSST---FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14194 234 YFSNTsalAKDFIRRLLVKDPKKRMTIQDSLQHPWI 269
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
20-277 8.81e-26

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 107.78  E-value: 8.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd14195   7 YEMGEELGSGQFAIVRKCREKGTGKEYAAKFIKKRRlsssrrGVSREEIEREVNILREIQHPNIITLHDIFENKTDVVLI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG----DVKLADFGVAAKITATi 169
Cdd:cd14195  87 LELVSGGELFDFLAEKESLTEEEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNvpnpRIKLIDFGIAHKIEAG- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAVEKNGgynQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQppklKDKTKWSST 249
Cdd:cd14195 166 NEFKNIFGTPEFVAPEIVNYEPLG---LEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYD----FDEEYFSNT 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 250 FH---NFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14195 239 SElakDFIRRLLVKDPKKRMTIAQSLEHSWI 269
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
19-277 9.47e-26

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 107.09  E-value: 9.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--------PGDDFSLIQQEIFM---VKECKHCNIVAYFGSYLSR 87
Cdd:cd14004   1 DYTILKEMGEGAYGQVNLAIYKSKGKEVVIKFIFKErilvdtwvRDRKLGTVPLEIHIldtLNKRSHPNIVKLLDFFEDD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGG-SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd14004  81 EFYYLVMEKHGSGmDLFDFIERKPNMDEKEAKYIFRQVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDFGSAAYIK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 AtiAKRKSFIGTPYWMAPEVAAVEKNGGYNQlcDIWAVGITAIELgelqppMFDLHPMRALFLMSKSNFQPPKLKDKTKW 246
Cdd:cd14004 161 S--GPFDTFVGTIDYAAPEVLRGNPYGGKEQ--DIWALGVLLYTL------VFKENPFYNIEEILEADLRIPYAVSEDLI 230
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 247 SstfhnFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14004 231 D-----LISRMLNRDVGDRPTIEELLTDPWL 256
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
14-277 1.08e-25

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 111.65  E-value: 1.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   14 RNPQQD-YELVQRVGSGTYGDVYKA-RNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:PTZ00267  62 NNPREHmYVLTTLVGRNPTTAAFVAtRGSDPKEKVVAKFVMLNDERQAAYARSELHCLAACDHFGIVKHFDDFKSDDKLL 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   92 ICMEYCGGGSLQDIY------HVtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI 165
Cdd:PTZ00267 142 LIMEYGSGGDLNKQIkqrlkeHL--PFQEYEVGLLFYQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGFSKQY 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  166 TATIA--KRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQP-Pklkd 242
Cdd:PTZ00267 220 SDSVSldVASSFCGTPYYLAPELWERKR---YSKKADMWSLGVILYELLTLHRPFKGPSQREIMQQVLYGKYDPfP---- 292
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 38570135  243 kTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:PTZ00267 293 -CPVSSGMKALLDPLLSKNPALRPTTQQLLHTEFL 326
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
20-277 1.40e-25

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 107.50  E-value: 1.40e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRV-GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14090   3 YKLTGELlGEGAYASVQTCINLYTGKEYAVKIIEKHPGHSRSRVFREVETLHQCQgHPNILQLIEYFEDDERFYLVFEKM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKIT-------- 166
Cdd:cd14090  83 RGGPLLSHIEKRVHFTEQEASLVVRDIASALDFLHDKGIAHRDLKPENILCESMDKvspVKICDFDLGSGIKlsstsmtp 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKSFIGTPYWMAPEV--AAVEKNGGYNQLCDIWAVGITAIELGELQPPMF----------------DLHPMraLF 228
Cdd:cd14090 163 VTTPELLTPVGSAEYMAPEVvdAFVGEALSYDKRCDLWSLGVILYIMLCGYPPFYgrcgedcgwdrgeacqDCQEL--LF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 38570135 229 LMSKSN-FQPPKlKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14090 241 HSIQEGeYEFPE-KEWSHISAEAKDLISHLLVRDASQRYTAEQVLQHPWV 289
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
20-275 1.44e-25

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 107.38  E-value: 1.44e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK-----LWICM 94
Cdd:cd13986   2 YRIQRLLGEGGFSFVYLVEDLSTGRLYALKKILCHSKEDVKEAMREIENYRLFNHPNILRLLDSQIVKEAggkkeVYLLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYH---VTG-PLSELQIAYVCRETLQGLAYLH---TKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd13986  82 PYYKRGSLQDEIErrlVKGtFFPEDRILHIFLGICRGLKAMHepeLVPYAHRDIKPGNVLLSEDDEPILMDLGSMNPARI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFI---------GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITaielgeLQPPMFDLHPMRALFLMSKS----- 233
Cdd:cd13986 162 EIEGRREALalqdwaaehCTMPYRAPELFDVKSHCTIDEKTDIWSLGCT------LYALMYGESPFERIFQKGDSlalav 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 38570135 234 ---NFQPPklkDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHT 275
Cdd:cd13986 236 lsgNYSFP---DNSRYSEELHQLVKSMLVVNPAERPSIDDLLSRV 277
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
20-273 1.82e-25

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 106.45  E-value: 1.82e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDdFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14072   2 YRLLKTIGKGNFAKVKLARHVLTGREVAIKIIdktQLNPSS-LQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRKSFI 176
Cdd:cd14072  81 ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTPG-NKLDTFC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNqlCDIWAVGITAIELGELQPPmFD---LHPMRALFLMSKsnFQPPKLKdktkwSSTFHNF 253
Cdd:cd14072 160 GSPPYAAPELFQGKKYDGPE--VDVWSLGVILYTLVSGSLP-FDgqnLKELRERVLRGK--YRIPFYM-----STDCENL 229
                       250       260
                ....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAERLLT 273
Cdd:cd14072 230 LKKFLVLNPSKRGTLEQIMK 249
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
19-277 2.21e-25

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 106.63  E-value: 2.21e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQR--VGSGTYGDVYKARNVHTG--ELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14201   5 DFEYSRKdlVGHGAFAVVFKGRHRKKTdwEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQEMPNSVFLVM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG---------DVKLADFGVAAKI 165
Cdd:cd14201  85 EYCNGGDLADYLQAKGTLSEDTIRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASrkkssvsgiRIKIADFGFARYL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATIAKrKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTk 245
Cdd:cd14201 165 QSNMMA-ATLCGSPMYMAPEVIMSQH---YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKNLQPSIPRET- 239
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 246 wSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14201 240 -SPYLADLLLGLLQRNQKDRMDFEAFFSHPFL 270
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
26-272 2.49e-25

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 106.59  E-value: 2.49e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnVHTGELAAVKiiKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYL-SREKLWICmEYCGGGS 101
Cdd:cd14066   1 IGSGGFGTVYKGV-LENGTVVAVK--RLNEMNCAASKKEfltELEMLGRLRHPNLVRLLGYCLeSDEKLLVY-EYMPNGS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTG---PLSELQIAYVCRETLQGLAYLHTKGK---MHRDIKGANILLTDHGDVKLADFGVAAKIT--ATIAKRK 173
Cdd:cd14066  77 LEDRLHCHKgspPLPWPQRLKIAKGIARGLEYLHEECPppiIHGDIKSSNILLDEDFEPKLTDFGLARLIPpsESVSKTS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPpklkdktKWSSTFHNF 253
Cdd:cd14066 157 AVKGTIGYLAPEYI---RTGRVSTKSDVYSFGVVLLELLTGKPA-VDENRENASRKDLVEWVES-------KGKEELEDI 225
                       250       260
                ....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPT-AERLL 272
Cdd:cd14066 226 LDKRLVDDDGVEEEeVEALL 245
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
19-292 2.83e-25

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 106.56  E-value: 2.83e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDdfslIQQEI-FMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14091   1 EYEIKEEIGKGSYSVCKRCIHKATGKEYAVKIIDKSKRD----PSEEIeILLRYGQHPNIITLRDVYDDGNSVYLVTELL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG----DVKLADFGVAAKITAtiakRK 173
Cdd:cd14091  77 RGGELLDRILRQKFFSEREASAVMKTLTKTVEYLHSQGVVHRDLKPSNILYADESgdpeSLRICDFGFAKQLRA----EN 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTP-Y---WMAPEVAaveKNGGYNQLCDIWAVGITaielgelqppmfdLHPM---RALFLMSKSNFQPPKLK----- 241
Cdd:cd14091 153 GLLMTPcYtanFVAPEVL---KKQGYDAACDIWSLGVL-------------LYTMlagYTPFASGPNDTPEVILArigsg 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 242 ----DKTKW---SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ-PGLSRALAVELLD 292
Cdd:cd14091 217 kidlSGGNWdhvSDSAKDLVRKMLHVDPSQRPTAAQVLQHPWIRNrDSLPQRQLTDPQD 275
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
20-280 3.04e-25

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 105.84  E-value: 3.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIklEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14665   2 YELVKDIGSGNFGVARLMRDKQTKELVAVKYI--ERGEKIDEnVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL--TDHGDVKLADFGVaAKITATIAKRKSFI 176
Cdd:cd14665  80 GGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLdgSPAPRLKICDFGY-SKSSVLHSQPKSTV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGynQLCDIWAVGITaielgelqppmfdLHPMralfLMSKSNFQPPklKDKTKWSSTFHNF--V 254
Cdd:cd14665 159 GTPAYIAPEVLLKKEYDG--KIADVWSCGVT-------------LYVM----LVGAYPFEDP--EEPRNFRKTIQRIlsV 217
                       250       260
                ....*....|....*....|....*.
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFVAQP 280
Cdd:cd14665 218 QYSIPDYVHISPECRHLISRIFVADP 243
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
19-276 4.08e-25

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 107.39  E-value: 4.08e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDF--SLIQQEIFMVKEcKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd05615  11 DFNFLMVLGKGSFGKVMLAERKGSDELYAIKILKKDvviQDDDVecTMVEKRVLALQD-KPPFLTQLHSCFQTVDRLYFV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLqdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd05615  90 MEYVNGGDL--MYHIqqVGKFKEPQAVFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMVEGVT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQPPKLKDKTKWSstf 250
Cdd:cd05615 168 TRTFCGTPDYIAPEIIAYQP---YGRSVDWWAYGVLLYEMLAGQPP-FDGEDEDELFQsIMEHNVSYPKSLSKEAVS--- 240
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 251 hnFVKIALTKNPKKR----PTAER-LLTHTF 276
Cdd:cd05615 241 --ICKGLMTKHPAKRlgcgPEGERdIREHAF 269
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
26-206 4.25e-25

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 105.61  E-value: 4.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd13978   1 LGSGGFGTVSKARHVSWFGMVAIKCLHSSPNCIEerKALLKEAEKMERARHSYVLPLLGVCVERRSLGLVMEYMENGSLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYH-----VTGPLSeLQIAYvcrETLQGLAYLH--TKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA-----K 171
Cdd:cd13978  81 SLLEreiqdVPWSLR-FRIIH---EIALGMNFLHnmDPPLLHHDLKPENILLDNHFHVKISDFGLSKLGMKSISanrrrG 156
                       170       180       190
                ....*....|....*....|....*....|....*
gi 38570135 172 RKSFIGTPYWMAPEvAAVEKNGGYNQLCDIWAVGI 206
Cdd:cd13978 157 TENLGGTPIYMAPE-AFDDFNKKPTSKSDVYSFAI 190
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
26-277 4.91e-25

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 105.47  E-value: 4.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDV--YKARNVHTGELAAVKIIKLEPGDdfSLIQQEIFMV-KE----CK--HCNIVAYFGSYLSRE-KLWICME 95
Cdd:cd13994   1 IGKGATSVVriVTKKNPRSGVLYAVKEYRRRDDE--SKRKDYVKRLtSEyiisSKlhHPNIVKVLDLCQDLHgKWCLVME 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA----TIAK 171
Cdd:cd13994  79 YCPGGDLFTLIEKADSLSLEEKDCFFKQILRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGTAEVFGMpaekESPM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAaveKNGGYN-QLCDIWAVGITAIElgelqppMFDLhpmRALFLMSK---SNFQPPKLKDKTKWS 247
Cdd:cd13994 159 SAGLCGSEPYMAPEVF---TSGSYDgRAVDVWSCGIVLFA-------LFTG---RFPWRSAKksdSAYKAYEKSGDFTNG 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 248 STFHNFVKIA----------LTKNPKKRPTAERLLTHTFV 277
Cdd:cd13994 226 PYEPIENLLPsecrrliyrmLHPDPEKRITIDEALNDPWV 265
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
16-277 5.58e-25

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 104.90  E-value: 5.58e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14111   1 PQKPYTFLDEKARGRFGVIRRCRENATGKNFPAKIVPYQAEEKQGVLQ-EYEILKSLHHERIMALHEAYITPRYLVLIAE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGG----SLQDIYHvtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd14111  80 FCSGKellhSLIDRFR----YSEDDVVGYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQSFNPLSLR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKS-FIGTPYWMAPEVAAVEKNGgynQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTF 250
Cdd:cd14111 156 QLGrRTGTLEYMAPEMVKGEPVG---PPADIWSIGVLTYIMLSGRSPFEDQDPQETEAKILVAKFDAFKLYPNVSQSASL 232
                       250       260
                ....*....|....*....|....*..
gi 38570135 251 hnFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14111 233 --FLKKVLSSYPWSRPTTKDCFAHAWL 257
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
20-311 5.78e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 106.30  E-value: 5.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQ-QEIFMVKECKHCNIVAYF------GSYLSREK-- 89
Cdd:cd07865  14 YEKLAKIGQGTFGEVFKARHRKTGQIVALKKVLMEnEKEGFPITAlREIKILQLLKHENVVNLIeicrtkATPYNRYKgs 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCG---GGSLQDIYhVTGPLSElqIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AKI 165
Cdd:cd07865  94 IYLVFEFCEhdlAGLLSNKN-VKFTLSE--IKKVMKMLLNGLYYIHRNKILHRDMKAANILITKDGVLKLADFGLArAFS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATIAKRKSFIG---TPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK--SNFQPPKL 240
Cdd:cd07865 171 LAKNSQPNRYTNrvvTLWYRPPELLLGERD--YGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQlcGSITPEVW 248
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 241 KDKTKWSStfhnFVKIALTKNpKKRPTAERLLthtfvaqPGLSRALAVELLDK--VNNPDNHAHYTEADDDDF 311
Cdd:cd07865 249 PGVDKLEL----FKKMELPQG-QKRKVKERLK-------PYVKDPYALDLIDKllVLDPAKRIDADTALNHDF 309
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
26-278 6.06e-25

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 104.50  E-value: 6.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYkaRNVHTGELAAVKIIKLEPgddfsliQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14059   1 LGSGAQGAVF--LGKFRGEEVAVKKVRDEK-------ETDIKHLRKLNHPNIIKFKGVCTQAPCYCILMEYCPYGQLYEV 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKITATIAKRKSFIGTPYWMAPE 185
Cdd:cd14059  72 LRAGREITPSLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFG-TSKELSEKSTKMSFAGTVAWMAPE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 186 VAaveKNGGYNQLCDIWAVGITAIEL--GELqpPMFDLHPMRALFLMSKSNFQPP---------KLKDKTKWSStfhnfv 254
Cdd:cd14059 151 VI---RNEPCSEKVDIWSFGVVLWELltGEI--PYKDVDSSAIIWGVGSNSLQLPvpstcpdgfKLLMKQCWNS------ 219
                       250       260
                ....*....|....*....|....
gi 38570135 255 kialtkNPKKRPTAERLLTHTFVA 278
Cdd:cd14059 220 ------KPRNRPSFRQILMHLDIA 237
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
15-266 6.53e-25

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 105.88  E-value: 6.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd08229  21 NTLANFRIEKKIGRGQFSEVYRATCLLDGVPVALKKVQIFDLMDAKARAdciKEIDLLKQLNHPNVIKYYASFIEDNELN 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSL-QDIYHVTGPLSELQIAYVCRETLQ---GLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd08229 101 IVLELADAGDLsRMIKHFKKQKRLIPEKTVWKYFVQlcsALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEvaAVEKNgGYNQLCDIWAVGITAIELGELQPPMF-DLHPMRALFLMSKSNFQPPKLKDktKW 246
Cdd:cd08229 181 KTTAAHSLVGTPYYMSPE--RIHEN-GYNFKSDIWSLGCLLYEMAALQSPFYgDKMNLYSLCKKIEQCDYPPLPSD--HY 255
                       250       260
                ....*....|....*....|
gi 38570135 247 SSTFHNFVKIALTKNPKKRP 266
Cdd:cd08229 256 SEELRQLVNMCINPDPEKRP 275
PK_STRAD_beta cd08226
Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain ...
34-279 6.78e-25

Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity.STRAD-beta is also referred to as ALS2CR2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein), since the human gene encoding it is located within the juvenile ALS2 critical region on chromosome 2q33-q34. It is not linked to the development of ALS2. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. The STRAD-beta subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270864 [Multi-domain]  Cd Length: 328  Bit Score: 106.49  E-value: 6.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  34 VYKARNVHTGELAAVKIIKLEPGDD--FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC---MEYCGGGSLQDIYHV 108
Cdd:cd08226  16 VYLARHTPTGTLVTVKITNLDNCSEehLKALQNEVVLSHFFRHPNIMTHWTVFTEGSWLWVIspfMAYGSARGLLKTYFP 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 109 TGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY-------W 181
Cdd:cd08226  96 EG-MNEALIGNILYGAIKALNYLHQNGCIHRSVKASHILISGDGLVSLSGLSHLYSMVTNGQRSKVVYDFPQfstsvlpW 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 182 MAPEVAAVEKNgGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS-------NFQPPKLKDKTK--------- 245
Cdd:cd08226 175 LSPELLRQDLH-GYNVKSDIYSVGITACELARGQVPFQDMRRTQMLLQKLKGppyspldIFPFPELESRMKnsqsgmdsg 253
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 246 --------------------------WSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd08226 254 igesvatssmtrtmtserlqtpssktFSPAFHNLVELCLQQDPEKRPSASSLLSHSFFKQ 313
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
20-276 7.06e-25

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 106.22  E-value: 7.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKAR--NVHTGELAAVKIIKLEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGSYLS--REKLWI 92
Cdd:cd07842   2 YEIEGCIGRGTYGRVYKAKrkNGKDGKEYAIKKFKGDKEQYTGISQsacREIALLRELKHENVVSLVEVFLEhaDKSVYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGggslQDIYHVTGPLSELQIAYVCRET--------LQGLAYLHTKGKMHRDIKGANILLT----DHGDVKLADFG 160
Cdd:cd07842  82 LFDYAE----HDLWQIIKFHRQAKRVSIPPSMvksllwqiLNGIHYLHSNWVLHRDLKPANILVMgegpERGVVKIGDLG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 161 VAAKITATIakrKSFIG------TPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQPP------------MFDLH 222
Cdd:cd07842 158 LARLFNAPL---KPLADldpvvvTIWYRAPELLLGARH--YTKAIDIWAIGCIFAELLTLEPIfkgreakikksnPFQRD 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 223 PMRALF----------------------LMSK---SNFQPPKL-----KDKTKWSSTFHNFVKIaLTKNPKKRPTAERLL 272
Cdd:cd07842 233 QLERIFevlgtptekdwpdikkmpeydtLKSDtkaSTYPNSLLakwmhKHKKPDSQGFDLLRKL-LEYDPTKRITAEEAL 311

                ....
gi 38570135 273 THTF 276
Cdd:cd07842 312 EHPY 315
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
19-276 8.90e-25

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 106.24  E-value: 8.90e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDF--SLIQQEIFMVKEcKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd05616   1 DFNFLMVLGKGSFGKVMLAERKGTDELYAVKILKKDvviQDDDVecTMVEKRVLALSG-KPPFLTQLHSCFQTMDRLYFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLqdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd05616  80 MEYVNGGDL--MYHIqqVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFL-MSKSNFQPPKLKDKTKWSstf 250
Cdd:cd05616 158 TKTFCGTPDYIAPEIIAYQP---YGKSVDWWAFGVLLYEMLAGQAP-FEGEDEDELFQsIMEHNVAYPKSMSKEAVA--- 230
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 251 hnFVKIALTKNPKKR----PTAER-LLTHTF 276
Cdd:cd05616 231 --ICKGLMTKHPGKRlgcgPEGERdIKEHAF 259
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
20-278 1.33e-24

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 104.59  E-value: 1.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14169   5 YELKEKLGEGAFSEVVLAQERGSQRLVALKCIpkKALRGKE-AMVENEIAVLRRINHENIVSLEDIYESPTHLYLAMELV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKL--ADFGVaAKITATIAKRKS 174
Cdd:cd14169  84 TGGELFDRIIERGSYTEKDASQLIGQVLQAVKYLHQLGIVHRDLKPENLLYaTPFEDSKImiSDFGL-SKIEAQGMLSTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 fIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLH--PMRALFLMSKSNFQPPKLKDktkWSSTFHN 252
Cdd:cd14169 163 -CGTPGYVAPELL---EQKPYGKAVDVWAIGVISYILLCGYPPFYDENdsELFNQILKAEYEFDSPYWDD---ISESAKD 235
                       250       260
                ....*....|....*....|....*.
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd14169 236 FIRHLLERDPEKRFTCEQALQHPWIS 261
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
13-278 1.35e-24

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 106.32  E-value: 1.35e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  13 RRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd05593  10 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEviiAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDR 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05593  90 LCFVMEYVNGGEL--FFHLSRErvFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGIT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFqPPKLkdktk 245
Cdd:cd05593 168 DAATMKTFCGTPEYLAPEV--LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYnqDHEKLFELILMEDIKF-PRTL----- 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 246 wSSTFHNFVKIALTKNPKKR-----PTAERLLTHTFVA 278
Cdd:cd05593 239 -SADAKSLLSGLLIKDPNKRlgggpDDAKEIMRHSFFT 275
KIND smart00750
kinase non-catalytic C-lobe domain; It is an interaction domain identified as being similar to ...
100-277 1.90e-24

kinase non-catalytic C-lobe domain; It is an interaction domain identified as being similar to the C-terminal protein kinase catalytic fold (C lobe). Its presence at the N terminus of signalling proteins and the absence of the active-site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of KIND only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features


Pssm-ID: 214801  Cd Length: 176  Bit Score: 100.94  E-value: 1.90e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    100 GSLQDIYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHrdikgaNILLTDHGDVKLadFGVAAKITATIAkrksfIGT 178
Cdd:smart00750   1 VSLADILEVRGrPLNEEEIWAVCLQCLGALRELHRQAKSG------NILLTWDGLLKL--DGSVAFKTPEQS-----RPD 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF--LMSKS-NFQPPKLKDKTKWSS--TFHNF 253
Cdd:smart00750  68 PYFMAPEVI---QGQSYTEKADIYSLGITLYEALDYELPYNEERELSAILeiLLNGMpADDPRDRSNLEGVSAarSFEDF 144
                          170       180
                   ....*....|....*....|....
gi 38570135    254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:smart00750 145 MRLCASRLPQRREAANHYLAHCRA 168
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
24-273 2.26e-24

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 103.62  E-value: 2.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKArnVHTGELAAVKIIKLEPGDDFSL--IQQEIfMVKECKHCNIV--------AYFGSYLSreklwIC 93
Cdd:cd13979   9 EPLGSGGFGSVYKA--TYKGETVAVKIVRRRRKNRASRqsFWAEL-NAARLRHENIVrvlaaetgTDFASLGL-----II 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQD-IYHVTGPLS-ELQIAYVCrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd13979  81 MEYCGNGTLQQlIYEGSEPLPlAHRILISL-DIARALRFCHSHGIVHLDVKPANILISEQGVCKLCDFGCSVKLGEGNEV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 ---RKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMrALFLMSKSNFQP--PKLKDKTKw 246
Cdd:cd13979 160 gtpRSHIGGTYTYRAPELL---KGERVTPKADIYSFGITLWQMLTRELPYAGLRQH-VLYAVVAKDLRPdlSGLEDSEF- 234
                       250       260
                ....*....|....*....|....*..
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLT 273
Cdd:cd13979 235 GQRLRSLISRCWSAQPAERPNADESLL 261
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
14-272 2.32e-24

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 107.65  E-value: 2.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREK- 89
Cdd:PTZ00283  28 KEQAKKYWISRVLGSGATGTVLCAKRVSDGEPFAVKVVDMEgmsEADKNR-AQAEVCCLLNCDFFSIVKCHEDFAKKDPr 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   90 -------LWICMEYCGGGSL-QDIYH---VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLAD 158
Cdd:PTZ00283 107 npenvlmIALVLDYANAGDLrQEIKSrakTNRTFREHEAGLLFIQVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLGD 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  159 FGVAAKITATIAKR--KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRAlfLMSKS--- 233
Cdd:PTZ00283 187 FGFSKMYAATVSDDvgRTFCGTPYYVAPEIW---RRKPYSKKADMFSLGVLLYELLTLKRP-FDGENMEE--VMHKTlag 260
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 38570135  234 NFQPpkLKDKTkwSSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:PTZ00283 261 RYDP--LPPSI--SPEMQEIVTALLSSDPKRRPSSSKLL 295
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
26-316 2.84e-24

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 104.70  E-value: 2.84e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05595   3 LGKGTFGKVILVREKATGRYYAMKILRKEviiAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGEL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 qdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Cdd:cd05595  83 --FFHLSRErvFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGITDGATMKTFCGTPE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 WMAPEVaaVEKNgGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFqPPKLKDKTKwsstfhNFVKIAL 258
Cdd:cd05595 161 YLAPEV--LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYnqDHERLFELILMEEIRF-PRTLSPEAK------SLLAGLL 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 259 TKNPKKR----PT-AERLLTHTFVA----QPGLSRALAVELLDKVNNPDNHAHYteadDDDFEPHAI 316
Cdd:cd05595 231 KKDPKQRlgggPSdAKEVMEHRFFLsinwQDVVQKKLLPPFKPQVTSEVDTRYF----DDEFTAQSI 293
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
20-277 3.66e-24

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 103.49  E-value: 3.66e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--------------------KLEPGDD------FSLIQQEIFMVKECK 73
Cdd:cd14200   2 YKLQSEIGKGSYGVVKLAYNESDDKYYAMKVLskkkllkqygfprrppprgsKAAQGEQakplapLERVYQEIAILKKLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  74 HCNIVAYFGSY--LSREKLWICMEYCGGGSLQDIyHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH 151
Cdd:cd14200  82 HVNIVKLIEVLddPAEDNLYMVFDLLRKGPVMEV-PSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 152 GDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHpmrALFLMS 231
Cdd:cd14200 161 GHVKIADFGVSNQFEGNDALLSSTAGTPAFMAPETLSDSGQSFSGKALDVWAMGVTLYCFVYGKCPFIDEF---ILALHN 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 232 KSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14200 238 KIKNKPVEFPEEPEISEELKDLILKMLDKNPETRITVPEIKVHPWV 283
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
19-277 4.43e-24

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 102.53  E-value: 4.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF---------SLIQQEIFMVKEC------KHCNIVAYFGS 83
Cdd:cd14077   2 NWEFVKTIGAGSMGKVKLAKHIRTGEKCAIKIIPRASNAGLkkerekrleKEISRDIRTIREAalssllNHPHICRLRDF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  84 YLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaA 163
Cdd:cd14077  82 LRTPNHYYMLFEYVDGGQLLDYIISHGKLKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGL-S 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNqlCDIWAVGITAIELGELQPPmFDLHPMRALFlmsksnfqpPKLKD- 242
Cdd:cd14077 161 NLYDPRRLLRTFCGSLYFAAPELLQAQPYTGPE--VDVWSFGVVLYVLVCGKVP-FDDENMPALH---------AKIKKg 228
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 38570135 243 KTKWSSTFHNFVKIALTK----NPKKRPTAERLLTHTFV 277
Cdd:cd14077 229 KVEYPSYLSSECKSLISRmlvvDPKKRATLEQVLNHPWM 267
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
26-211 5.55e-24

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 101.80  E-value: 5.55e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLePGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14065   1 LGKGFFGEVYKVTHRETGKVMVMKELKR-FDEQRSFLK-EVKLMRRLSHPNILRFIGVCVKDNKLNFITEYVNGGTLEEL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 Y-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL--TDHG-DVKLADFGVAAKITATIAK---RK---SF 175
Cdd:cd14065  79 LkSMDEQLPWSQRVSLAKDIASGMAYLHSKNIIHRDLNSKNCLVreANRGrNAVVADFGLAREMPDEKTKkpdRKkrlTV 158
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 38570135 176 IGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd14065 159 VGSPYWMAPEMLRGES---YDEKVDVFSFGIVLCEI 191
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
26-276 6.73e-24

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 103.24  E-value: 6.73e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDF--SLIQQEIFMVKEcKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd05587   4 LGKGSFGKVMLAERKGTDELYAIKILKKDviiQDDDVecTMVEKRVLALSG-KPPFLTQLHSCFQTMDRLYFVMEYVNGG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLqdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGT 178
Cdd:cd05587  83 DL--MYHIqqVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEGIFGGKTTRTFCGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLKDKTKwsstfhNFVKI 256
Cdd:cd05587 161 PDYIAPEIIAYQP---YGKSVDWWAYGVLLYEMLAGQPP-FDGEDEDELFqsIMEHNVSYPKSLSKEAV------SICKG 230
                       250       260
                ....*....|....*....|....*
gi 38570135 257 ALTKNPKKR----PTAER-LLTHTF 276
Cdd:cd05587 231 LLTKHPAKRlgcgPTGERdIKEHPF 255
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
20-277 7.04e-24

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 101.96  E-value: 7.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd14196   7 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQsrasrrGVSREEIEREVSILRQVLHPNIITLHDVYENRTDVVLI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG----DVKLADFGVAAKITATI 169
Cdd:cd14196  87 LELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNipipHIKLIDFGLAHEIEDGV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 aKRKSFIGTPYWMAPEVAAVEKNGgynQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQppklKDKTKWSST 249
Cdd:cd14196 167 -EFKNIFGTPEFVAPEIVNYEPLG---LEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD----FDEEFFSHT 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 250 FH---NFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14196 239 SElakDFIRKLLVKETRKRLTIQEALRHPWI 269
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
20-205 7.14e-24

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 102.37  E-value: 7.14e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07835   1 YQKLEKIGEGTYGVVYKARDKLTGEIVALKKIRLETEDEGvpSTAIREISLLKELNHPNIVRLLDVVHSENKLYLVFEFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GggslQDI-----YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd07835  81 D----LDLkkymdSSPLTGLDPPLIKSYLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGALKLADFGLARAFGVPVRTY 156
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 173 KSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVG 205
Cdd:cd07835 157 THEVVTLWYRAPEILLGSKH--YSTPVDIWSVG 187
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
20-207 7.15e-24

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 101.77  E-value: 7.15e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14662   2 YELVKDIGSGNFGVARLMRNKETKELVAVKYIERGLKIDEN-VQREIINHRSLRHPNIIRFKEVVLTPTHLAIVMEYAAG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH--GDVKLADFGVaAKITATIAKRKSFIG 177
Cdd:cd14662  81 GELFERICNAGRFSEDEARYFFQQLISGVSYCHSMQICHRDLKLENTLLDGSpaPRLKICDFGY-SKSSVLHSQPKSTVG 159
                       170       180       190
                ....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEKNGGynQLCDIWAVGIT 207
Cdd:cd14662 160 TPAYIAPEVLSRKEYDG--KVADVWSCGVT 187
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
19-281 8.79e-24

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 107.90  E-value: 8.79e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK---LEPGDDFSLIqQEIFMVKECKHCNIVAYFGSYLSR--EKLWIC 93
Cdd:PTZ00266   14 EYEVIKKIGNGRFGEVFLVKHKRTQEFFCWKAISyrgLKEREKSQLV-IEVNVMRELKHKNIVRYIDRFLNKanQKLYIL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135    94 MEYCGGGSL----QDIYHVTGPLSELQIAYVCRETLQGLAYLHT-----KGK--MHRDIKGANILLTD---H-GDV---- 154
Cdd:PTZ00266   93 MEFCDAGDLsrniQKCYKMFGKIEEHAIVDITRQLLHALAYCHNlkdgpNGErvLHRDLKPQNIFLSTgirHiGKItaqa 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   155 ---------KLADFGVAAKItATIAKRKSFIGTPYWMAPEVaAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMR 225
Cdd:PTZ00266  173 nnlngrpiaKIGDFGLSKNI-GIESMAHSCVGTPYYWSPEL-LLHETKSYDDKSDMWALGCIIYELCSGKTPFHKANNFS 250
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135   226 ALFLMSKsnfQPPKLKDKTKwSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPG 281
Cdd:PTZ00266  251 QLISELK---RGPDLPIKGK-SKELNILIKNLLNLSAKERPSALQCLGYQIIKNVG 302
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
19-277 1.12e-23

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 101.52  E-value: 1.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNvHTGELAAVKIIKLEpGDDFSLIQ---QEIFMVKECKHC-NIVAYFGSYLSRE--KLWI 92
Cdd:cd14131   2 PYEILKQLGKGGSSKVYKVLN-PKKKIYALKRVDLE-GADEQTLQsykNEIELLKKLKGSdRIIQLYDYEVTDEddYLYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEyCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDhGDVKLADFGVAAKI---TA 167
Cdd:cd14131  80 VME-CGEIDLATILkkKRPKPIDPNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANFLLVK-GRLKLIDFGIAKAIqndTT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIaKRKSFIGTPYWMAPEVAAVEKNGGYNQLC-------DIWAVGITAIELGELQPPMFDL-HPMRALFLMSKSNFQ--- 236
Cdd:cd14131 158 SI-VRDSQVGTLNYMSPEAIKDTSASGEGKPKskigrpsDVWSLGCILYQMVYGKTPFQHItNPIAKLQAIIDPNHEief 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 38570135 237 ----PPKLKDktkwsstfhnFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14131 237 pdipNPDLID----------VMKRCLQRDPKKRPSIPELLNHPFL 271
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
60-276 1.17e-23

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 100.90  E-value: 1.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  60 SLIQQEIFMVKECKHCNIVAYFGSYLSRE------KLWICMEYCGGGSLQDIYHVTGPLSelqIAYVCRETLQ---GLAY 130
Cdd:cd14012  43 QLLEKELESLKKLRHPNLVSYLAFSIERRgrsdgwKVYLLTEYAPGGSLSELLDSVGSVP---LDTARRWTLQlleALEY 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 131 LHTKGKMHRDIKGANILLTDH---GDVKLADFGVAAKITATIAKRKSFIGTP-YWMAPEVAAVekNGGYNQLCDIWAVGI 206
Cdd:cd14012 120 LHRNGVVHKSLHAGNVLLDRDagtGIVKLTDYSLGKTLLDMCSRGSLDEFKQtYWLPPELAQG--SKSPTRKTDVWDLGL 197
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135 207 TAIELgelqppMFDLHPmralflmsKSNFQPPK-LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14012 198 LFLQM------LFGLDV--------LEKYTSPNpVLVSLDLSASLQDFLSKCLSLDPKKRPTALELLPHEF 254
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
11-279 1.38e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 103.02  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  11 ILRRnpqqdYELVQRVGSGTYGDVYKARNVHTGELAAVKIIklepgddFSLIQ---------QEIFMVKECKHC-NIVAY 80
Cdd:cd07852   5 ILRR-----YEILKKLGKGAYGIVWKAIDKKTGEVVALKKI-------FDAFRnatdaqrtfREIMFLQELNDHpNIIKL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  81 FGS---------YLSREklwiCMEycgggslQDIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT 149
Cdd:cd07852  73 LNViraendkdiYLVFE----YME-------TDLHAVirANILEDIHKQYIMYQLLKALKYLHSGGVIHRDLKPSNILLN 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 150 DHGDVKLADFGVAAKITATIAKRKSFIGTPY----WM-APEVAAVEKNggYNQLCDIWAVG-ItaieLGEL--QPPMF-- 219
Cdd:cd07852 142 SDCRVKLADFGLARSLSQLEEDDENPVLTDYvatrWYrAPEILLGSTR--YTKGVDMWSVGcI----LGEMllGKPLFpg 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 220 --------------------DLHPMRALF----LMSKSNFQPPKLKDK-TKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd07852 216 tstlnqlekiievigrpsaeDIESIQSPFaatmLESLPPSRPKSLDELfPKASPDALDLLKKLLVFNPNKRLTAEEALRH 295

                ....*
gi 38570135 275 TFVAQ 279
Cdd:cd07852 296 PYVAQ 300
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
24-210 1.92e-23

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 100.21  E-value: 1.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05041   1 EKIGRGNFGDVYRGVLKPDNTEVAVKTCRETlPPDLKRKFLQEARILKQYDHPNIVKLIGVCVQKQPIMIVMELVPGGSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV----AAKITATIAKRKSFig 177
Cdd:cd05041  81 LTFLRKKGArLTVKQLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMsreeEDGEYTVSDGLKQI-- 158
                       170       180       190
                ....*....|....*....|....*....|....
gi 38570135 178 tPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIE 210
Cdd:cd05041 159 -PIkWTAPEAL---NYGRYTSESDVWSFGILLWE 188
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
27-160 1.98e-23

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 96.74  E-value: 1.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK--HCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd13968   2 GEGASAKVFWAEGECTTIGVAVKIGDDVNNEEGEDLESEMDILRRLKglELNIPKVLVTEDVDGPNILLMELVKGGTLIA 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 105 iYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG 160
Cdd:cd13968  82 -YTQEEELDEKDVESIMYQLAECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
18-277 2.19e-23

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 100.42  E-value: 2.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14116   5 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLfkaQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLIL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAakITATIAKRKS 174
Cdd:cd14116  85 EYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF-LMSKSNFQ-PPKLKDKTKwsstfhN 252
Cdd:cd14116 163 LCGTLDYLPPEMI---EGRMHDEKVDLWSLGVLCYEFLVGKPP-FEANTYQETYkRISRVEFTfPDFVTEGAR------D 232
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14116 233 LISRLLKHNPSQRPMLREVLEHPWI 257
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
20-277 2.49e-23

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 100.87  E-value: 2.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRV-GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14173   3 YQLQEEVlGEGAYARVQTCINLITNKEYAVKIIEKRPGHSRSRVFREVEMLYQCQgHRNVLELIEFFEEEDKFYLVFEKM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIlLTDHGD----VKLADFGVAAKItaTIAKRK 173
Cdd:cd14173  83 RGGSILSHIHRRRHFNELEASVVVQDIASALDFLHNKGIAHRDLKPENI-LCEHPNqvspVKICDFDLGSGI--KLNSDC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTP---------YWMAPEV--AAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDL----------HPMRALFLMSK 232
Cdd:cd14173 160 SPISTPelltpcgsaEYMAPEVveAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGRcgsdcgwdrgEACPACQNMLF 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 233 SNFQPPKL----KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14173 240 ESIQEGKYefpeKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 288
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
20-279 2.58e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 101.83  E-value: 2.58e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKiiKLEPGDDFSL----IQQEIFMVKECKHCNIVAYF-----GSYLSREKL 90
Cdd:cd07834   2 YELLKPIGSGAYGVVCSAYDKRTGRKVAIK--KISNVFDDLIdakrILREIKILRHLKHENIIGLLdilrpPSPEEFNDV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGgSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd07834  80 YIVTELMET-DLHKVIKSPQPLTDDHIQYFLYQILRGLKYLHSAGVIHRDLKPSNILVNSNCDLKICDFGLARGVDPDED 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRK--SFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL--------GE-----LQ--------PPMFDLHP---M 224
Cdd:cd07834 159 KGFltEYVVTRWYRAPELLLSSKK--YTKAIDIWSVGCIFAELltrkplfpGRdyidqLNlivevlgtPSEEDLKFissE 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 225 RAL-FLMSKSNFQPPKLKDKTKWSST-FHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd07834 237 KARnYLKSLPKKPKKPLSEVFPGASPeAIDLLEKMLVFNPKKRITADEALAHPYLAQ 293
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
23-220 4.57e-23

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 99.65  E-value: 4.57e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd14192   9 HEVLGGGRFGQVHKCTELSTGLTLAAKIIKVKGAKEREEVKNEINIMNQLNHVNLIQLYDAFESKTNLTLIMEYVDGGEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH--GDVKLADFGVAAKITATiAKRKSFIGTP 179
Cdd:cd14192  89 FDrITDESYQLTELDAILFTRQICEGVHYLHQHYILHLDLKPENILCVNStgNQIKIIDFGLARRYKPR-EKLKVNFGTP 167
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 38570135 180 YWMAPEVAAVEKnggYNQLCDIWAVG-ITAIELGELQPPMFD 220
Cdd:cd14192 168 EFLAPEVVNYDF---VSFPTDMWSVGvITYMLLSGLSPFLGE 206
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
26-211 5.27e-23

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 99.09  E-value: 5.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLiqQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14155   1 IGSGFFSEVYKVRHRTSGQVMALKMNTLSSNRANML--REVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINGGNLEQL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITATIAK--RKSFIGTPY 180
Cdd:cd14155  79 LDSNEPLSWTVRVKLALDIARGLSYLHSKGIFHRDLTSKNCLIKRDENgytAVVGDFGLAEKIPDYSDGkeKLAVVGSPY 158
                       170       180       190
                ....*....|....*....|....*....|.
gi 38570135 181 WMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14155 159 WMAPEVL---RGEPYNEKADVFSYGIILCEI 186
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
24-277 6.05e-23

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 99.61  E-value: 6.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIK-LEPGDDF-SLIQQEIFMVKECKHC-NIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd14198  14 KELGRGKFAVVRQCISKSTGQEYAAKFLKkRRRGQDCrAEILHEIAVLELAKSNpRVVNLHEVYETTSEIILILEYAAGG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 slqDIYHVTGP-----LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD---HGDVKLADFGVAAKITATIAKR 172
Cdd:cd14198  94 ---EIFNLCVPdlaemVSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSiypLGDIKIVDFGMSRKIGHACELR 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KsFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKlKDKTKWSSTFHN 252
Cdd:cd14198 171 E-IMGTPEYLAPEILNYDP---ITTATDMWNIGVIAYMLLTHESPFVGEDNQETFLNISQVNVDYSE-ETFSSVSQLATD 245
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14198 246 FIQKLLVKNPEKRPTAEICLSHSWL 270
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
20-277 6.86e-23

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 99.88  E-value: 6.86e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQ-QEIFMVKECKHCNIVAYFGSYLS----------R 87
Cdd:cd07864   9 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDnEKEGFPITAiREIKILRQLNHRSVVNLKEIVTDkqdaldfkkdK 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITA 167
Cdd:cd07864  89 GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLLEGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGL-ARLYN 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKR--KSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITaieLGEL--QPPMFDLH-PMRALFLMSKSNFQP----- 237
Cdd:cd07864 168 SEESRpyTNKVITLWYRPPELLLGEER--YGPAIDVWSCGCI---LGELftKKPIFQANqELAQLELISRLCGSPcpavw 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 238 -------------PKLKDKTKWSSTFHNFVKIA-------LTKNPKKRPTAERLLTHTFV 277
Cdd:cd07864 243 pdviklpyfntmkPKKQYRRRLREEFSFIPTPAldlldhmLTLDPSKRCTAEQALNSPWL 302
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
16-277 7.10e-23

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 99.92  E-value: 7.10e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL-----EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd14094   1 FEDVYELCEVIGKGPFSVVRRCIHRETGQQFAVKIVDVakftsSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQ-DIYH--VTGPL-SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---DHGDVKLADFGVAA 163
Cdd:cd14094  81 YMVFEFMDGADLCfEIVKraDAGFVySEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLAskeNSAPVKLGGFGVAI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGITaielgelqppMFDLHPMRALFLMSKSNFQPPKLKDK 243
Cdd:cd14094 161 QLGESGLVAGGRVGTPHFMAPEV--VKRE-PYGKPVDVWGCGVI----------LFILLSGCLPFYGTKERLFEGIIKGK 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 38570135 244 TK-----W---SSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14094 228 YKmnprqWshiSESAKDLVRRMLMLDPAERITVYEALNHPWI 269
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
27-265 7.32e-23

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 100.51  E-value: 7.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLq 103
Cdd:cd05571   4 GKGTFGKVILCREKATGELYAIKILKKEviiAKDEVAHTLTENRVLQNTRHPFLTSLKYSFQTNDRLCFVMEYVNGGEL- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 dIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
Cdd:cd05571  83 -FFHLSreRVFSEDRTRFYGAEIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKEEISYGATTKTFCGTPEY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 182 MAPEVaaVEKNgGYNQLCDIWAVGITAIEL--GELqpPMF--DLHPMRALFLMSKSNFqPPKLKDKTKwsstfhNFVKIA 257
Cdd:cd05571 162 LAPEV--LEDN-DYGRAVDWWGLGVVMYEMmcGRL--PFYnrDHEVLFELILMEEVRF-PSTLSPEAK------SLLAGL 229

                ....*...
gi 38570135 258 LTKNPKKR 265
Cdd:cd05571 230 LKKDPKKR 237
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
20-274 8.26e-23

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 98.81  E-value: 8.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14107   4 YEVKEEIGRGTFGFVKRVTHKGNGECCAAKFIPLRSSTR-ARAFQERDILARLSHRRLTCLLDQFETRKTLILILELCSS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT--DHGDVKLADFGVAAKITATIAKRKSFiG 177
Cdd:cd14107  83 EELLDRLFLKGVVTEAEVKLYIQQVLEGIGYLHGMNILHLDIKPDNILMVspTREDIKICDFGFAQEITPSEHQFSKY-G 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPmRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIA 257
Cdd:cd14107 162 SPEFVAPEIVHQEP---VSAATDIWALGVIAYLSLTCHSPFAGEND-RATLLNVAEGVVSWDTPEITHLSEDAKDFIKRV 237
                       250
                ....*....|....*..
gi 38570135 258 LTKNPKKRPTAERLLTH 274
Cdd:cd14107 238 LQPDPEKRPSASECLSH 254
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
26-217 8.42e-23

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 98.62  E-value: 8.42e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFSL----IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd14061   2 IGVGGFGKVYRGI--WRGEEVAVKAARQDPDEDISVtlenVRQEARLFWMLRHPNIIALRGVCLQPPNLCLVMEYARGGA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDiyHVTG---PLSEL-----QIAyvcretlQGLAYLHTKGKM---HRDIKGANILL---TDHGDV-----KLADFGVA 162
Cdd:cd14061  80 LNR--VLAGrkiPPHVLvdwaiQIA-------RGMNYLHNEAPVpiiHRDLKSSNILIleaIENEDLenktlKITDFGLA 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 163 AKITATiaKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd14061 151 REWHKT--TRMSAAGTYAWMAPEVI---KSSTFSKASDVWSYGVLLWELLTGEVP 200
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
26-265 1.00e-22

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 99.14  E-value: 1.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCNIVAYfgSYLSREKLWICMEYCGGG 100
Cdd:cd05577   1 LGRGGFGEVCACQVKATGKMYACKKldkkrIKKKKGETMALNEKIILEKVSSPFIVSLAY--AFETKDKLCLVLTLMNGG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRKSFIGT 178
Cdd:cd05577  79 DLKyHIYNVGTRgFSEARAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAVEFKGG-KKIKGRVGT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRalflMSKSNFQPPKLKDKTKWSSTF----HNFV 254
Cdd:cd05577 158 HGYMAPEV--LQKEVAYDFSVDWFALGCMLYEMIAGRSP-FRQRKEK----VDKEELKRRTLEMAVEYPDSFspeaRSLC 230
                       250
                ....*....|.
gi 38570135 255 KIALTKNPKKR 265
Cdd:cd05577 231 EGLLQKDPERR 241
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
20-277 1.47e-22

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 98.74  E-value: 1.47e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgdDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14085   5 FEIESELGRGATSVVYRCRQKGTQKPYAVKKLKKTV--DKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVaAKITATIAKRKSFI 176
Cdd:cd14085  83 GELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPdapLKIADFGL-SKIVDQQVTMKTVC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAaveKNGGYNQLCDIWAVG-ITAIELGELQpPMFDLHPMRALF---LMSKSNFQPPKLKDKtkwSSTFHN 252
Cdd:cd14085 162 GTPGYCAPEIL---RGCAYGPEVDMWSVGvITYILLCGFE-PFYDERGDQYMFkriLNCDYDFVSPWWDDV---SLNAKD 234
                       250       260
                ....*....|....*....|....*
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14085 235 LVKKLIVLDPKKRLTTQQALQHPWV 259
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
20-220 1.56e-22

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 102.57  E-value: 1.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfsliqqEIFMVK---ECK------HCNIVAYF-----GSYL 85
Cdd:NF033483   9 YEIGERIGRGGMAEVYLAKDTRLDRDVAVKVLRPDLARD------PEFVARfrrEAQsaaslsHPNIVSVYdvgedGGIP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   86 sreklWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AK 164
Cdd:NF033483  83 -----YIVMEYVDGRTLKDYIREHGPLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIArAL 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135  165 ITATIAKRKSFIGTPYWMAPEVAAveknGGY--NQlCDIWAVGITaieLGEL---QPPmFD 220
Cdd:NF033483 158 SSTTMTQTNSVLGTVHYLSPEQAR----GGTvdAR-SDIYSLGIV---LYEMltgRPP-FD 209
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
25-272 1.65e-22

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 98.73  E-value: 1.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARnvHTGELAAVKiiKLEPGDDFS------LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14158  22 KLGEGGFGVVFKGY--INDKNVAVK--KLAAMVDIStedltkQFEQEIQVMAKCQHENLVELLGYSCDGPQLCLVYTYMP 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQD---IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA---AKITATIAKR 172
Cdd:cd14158  98 NGSLLDrlaCLNDTPPLSWHMRCKIAQGTANGINYLHENNHIHRDIKSANILLDETFVPKISDFGLArasEKFSQTIMTE 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KsFIGTPYWMAPEVAavekNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKS----------NFQPPKLKD 242
Cdd:cd14158 178 R-IVGTTAYMAPEAL----RGEITPKSDIFSFGVVLLEIITGLPP-VDENRDPQLLLDIKEeiedeektieDYVDKKMGD 251
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 243 ktkW-SSTFHNFVKIA---LTKNPKKRPTAERLL 272
Cdd:cd14158 252 ---WdSTSIEAMYSVAsqcLNDKKNRRPDIAKVQ 282
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
20-278 1.85e-22

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 99.00  E-value: 1.85e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL--EPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07869   7 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLqeEEGTPFTAIR-EASLLKGLKHANIVLLHDIIHTKETLTLVFEYV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177
Cdd:cd07869  86 HTDLCQYMDKHPGGLHPENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGE---LQPPMFDLH-PMRALFLM-------------SKSNFQPPKL 240
Cdd:cd07869 166 TLWYRPPDV--LLGSTEYSTCLDMWGVGCIFVEMIQgvaAFPGMKDIQdQLERIFLVlgtpnedtwpgvhSLPHFKPERF 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 241 K-----------DKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd07869 244 TlyspknlrqawNKLSYVNHAEDLASKLLQCFPKNRLSAQAALSHEYFS 292
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
20-279 1.90e-22

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 99.36  E-value: 1.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIklepGDDFSLIQ------QEIFMVKECKHCNIVAYFGSYLSREKL--- 90
Cdd:cd07855   7 YEPIETIGSGAYGVVCSAIDTKSGQKVAIKKI----PNAFDVVTtakrtlRELKILRHFKHDNIIAIRDILRPKVPYadf 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 ---WICMEYCGGgSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd07855  83 kdvYVVLDLMES-DLHHIIHSDQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLCT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSF----IGTPYWMAPEVAAVekNGGYNQLCDIWAVG-ITAIELG--ELQPPMFDLHPMRALFLMSKS------- 233
Cdd:cd07855 162 SPEEHKYFmteyVATRWYRAPELMLS--LPEYTQAIDMWSVGcIFAEMLGrrQLFPGKNYVHQLQLILTVLGTpsqavin 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 234 ------------NFQPpklKDKTKWSSTFH-------NFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd07855 240 aigadrvrryiqNLPN---KQPVPWETLYPkadqqalDLLSQMLRFDPSERITVAEALQHPFLAK 301
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
19-274 2.61e-22

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 98.02  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLePGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSR------EK- 89
Cdd:cd14048   7 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAVKRIRL-PNNELARekVLREVRALAKLDHPGIVRYFNAWLERppegwqEKm 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 ----LWICMEYCGGGSLQDIYHVTGPLSELQIAY---VCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd14048  86 devyLYIQMQLCRKENLKDWMNRRCTMESRELFVclnIFKQIASAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVGDFGLV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKI------------TATIAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELgeLQPPMFDLHPMRALFLM 230
Cdd:cd14048 166 TAMdqgepeqtvltpMPAYAKHTGQVGTRLYMSPEQI---HGNQYSEKVDIFALGLILFEL--IYSFSTQMERIRTLTDV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 38570135 231 SKSNFqPPKLKDKTKWSstfHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14048 241 RKLKF-PALFTNKYPEE---RDMVQQMLSPSPSERPEAHEVIEH 280
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
27-276 2.80e-22

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 98.44  E-value: 2.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05570   4 GKGSFGKVMLAERKKTDELYAIKVLKkeviIEDDDVECTMTEKRVLALANRHPFLTGLHACFQTEDRLYFVMEYVNGGDL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 qdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA------AKITATiakrks 174
Cdd:cd05570  84 --MFHIqrARRFTEERARFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCkegiwgGNTTST------ 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLKDKTKwsstfhN 252
Cdd:cd05570 156 FCGTPDYIAPEILREQD---YGFSVDWWALGVLLYEMLAGQSP-FEGDDEDELFeaILNDEVLYPRWLSREAV------S 225
                       250       260
                ....*....|....*....|....*....
gi 38570135 253 FVKIALTKNPKKR----PTAER-LLTHTF 276
Cdd:cd05570 226 ILKGLLTKDPARRlgcgPKGEAdIKAHPF 254
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
20-277 3.24e-22

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 96.83  E-value: 3.24e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14087   3 YDIKALIGRGSFSRVVRVEHRVTRQPYAIKMIETKCRGR-EVCESELNVLRRVRHTNIIQLIEVFETKERVYMVMELATG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG-DVKL--ADFGVAAKITATIAK-RKSF 175
Cdd:cd14087  82 GELFDRIIAKGSFTERDATRVLQMVLDGVKYLHGLGITHRDLKPENLLYYHPGpDSKImiTDFGLASTRKKGPNClMKTT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMR--ALFLMSKSNFQPPKLKDKtkwSSTFHNF 253
Cdd:cd14087 162 CGTPEYIAPEILLRKP---YTQSVDMWAVGVIAYILLSGTMPFDDDNRTRlyRQILRAKYSYSGEPWPSV---SNLAKDF 235
                       250       260
                ....*....|....*....|....
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14087 236 IDRLLTVNPGERLSATQALKHPWI 259
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
26-274 3.26e-22

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 96.91  E-value: 3.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL--- 102
Cdd:cd14103   1 LGRGKFGTVYRCVEKATGKELAAKFIKCRKAKDREDVRNEIEIMNQLRHPRLLQLYDAFETPREMVLVMEYVAGGELfer 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 --QDIYHvtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL---LTDHgDVKLADFGVAAKITATIAKRKSFiG 177
Cdd:cd14103  81 vvDDDFE----LTERDCILFMRQICEGVQYMHKQGILHLDLKPENILcvsRTGN-QIKIIDFGLARKYDPDKKLKVLF-G 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEKNGgynQLCDIWAVG-ITAIELGELQPPM--FDLHPMrALFLMSKSNFQPPKLKDKtkwSSTFHNFV 254
Cdd:cd14103 155 TPEFVAPEVVNYEPIS---YATDMWSVGvICYVLLSGLSPFMgdNDAETL-ANVTRAKWDFDDEAFDDI---SDEAKDFI 227
                       250       260
                ....*....|....*....|
gi 38570135 255 KIALTKNPKKRPTAERLLTH 274
Cdd:cd14103 228 SKLLVKDPRKRMSAAQCLQH 247
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
20-276 3.80e-22

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 97.73  E-value: 3.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD---FSLIQqEIFMVKECK---HCNIVAYF----GSYLSRE- 88
Cdd:cd07863   2 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVQTNEDglpLSTVR-EVALLKRLEafdHPNIVRLMdvcaTSRTDREt 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGggslQDI--YHVTGPLSEL---QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaA 163
Cdd:cd07863  81 KVTLVFEHVD----QDLrtYLDKVPPPGLpaeTIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGL-A 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQP------------PMFDLHPMRAL---- 227
Cdd:cd07863 156 RIYSCQMALTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPlfcgnseadqlgKIFDLIGLPPEddwp 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 228 --FLMSKSNFQP----PKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07863 233 rdVTLPRGAFSPrgprPVQSVVPEIEESGAQLLLEMLTFNPHKRISAFRALQHPF 287
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
20-216 4.14e-22

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 97.34  E-value: 4.14e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL--EPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07870   2 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMktEEGVPFTAIR-EASLLKGLKHANIVLLHDIIHTKETLTFVFEYM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177
Cdd:cd07870  81 HTDLAQYMIQHPGGLHPYNVRLFMFQLLRGLAYIHGQHILHRDLKPQNLLISYLGELKLADFGLARAKSIPSQTYSSEVV 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 38570135 178 TPYWMAPEV--AAVEknggYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07870 161 TLWYRPPDVllGATD----YSSALDIWGAGCIFIEMLQGQP 197
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
19-274 4.34e-22

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 96.59  E-value: 4.34e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRV-GSGTYGDVYKARNVHTGELAAVKIIKLEPGDdfsliQQEI---FMVKECKH-CNIV-AYFGSYLSREKLWI 92
Cdd:cd14089   1 DYTISKQVlGLGINGKVLECFHKKTGEKFALKVLRDNPKA-----RREVelhWRASGCPHiVRIIdVYENTYQGRKCLLV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSL----QDiyHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVaAKI 165
Cdd:cd14089  76 VMECMEGGELfsriQE--RADSAFTEREAAEIMRQIGSAVAHLHSMNIAHRDLKPENLLYSSKGPnaiLKLTDFGF-AKE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVG-ITAIELGELqPPMFDLH-----P-MRALFLMSKSNFQPP 238
Cdd:cd14089 153 TTTKKSLQTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGvIMYILLCGY-PPFYSNHglaisPgMKKRIRNGQYEFPNP 228
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 38570135 239 klkdktKW---SSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14089 229 ------EWsnvSEEAKDLIRGLLKTDPSERLTIEEVMNH 261
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
9-278 4.82e-22

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 98.56  E-value: 4.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   9 ADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECKHCNIVAYFGSYL 85
Cdd:cd05594  16 TKPKHKVTMNDFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEvivAKDEVAHTLTENRVLQNSRHPFLTALKYSFQ 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHT-KGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd05594  96 THDRLCFVMEYANGGEL--FFHLSRErvFSEDRARFYGAEIVSALDYLHSeKNVVYRDLKLENLMLDKDGHIKITDFGLC 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKITATIAKRKSFIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFqPPKL 240
Cdd:cd05594 174 KEGIKDGATMKTFCGTPEYLAPEV--LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYnqDHEKLFELILMEEIRF-PRTL 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 241 KDKTKwsstfhNFVKIALTKNPKKR-----PTAERLLTHTFVA 278
Cdd:cd05594 250 SPEAK------SLLSGLLKKDPKQRlgggpDDAKEIMQHKFFA 286
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
20-277 5.21e-22

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 96.57  E-value: 5.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgdDF---SLIQQEI--FMVKECK--HCNIVAYFGSYLSREKLWI 92
Cdd:cd14133   1 YEVLEVLGKGTFGQVVKCYDLLTGEEVALKIIKNNK--DYldqSLDEIRLleLLNKKDKadKYHIVRLKDVFYFKNHLCI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGG----SLQDIYHvtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD--VKLADFGVAAKIT 166
Cdd:cd14133  79 VFELLSQNlyefLKQNKFQ---YLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLASYSRcqIKIIDFGSSCFLT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAkrkSFIGTPYWMAPEVAAvekngG--YNQLCDIWAVGITAIEL--GElqpPMFD----------LHPMRALF---L 229
Cdd:cd14133 156 QRLY---SYIQSRYYRAPEVIL-----GlpYDEKIDMWSLGCILAELytGE---PLFPgasevdqlarIIGTIGIPpahM 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 230 MSKSNFQPPKLKDktkwsstfhnFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14133 225 LDQGKADDELFVD----------FLKKLLEIDPKERPTASQALSHPWL 262
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
22-271 5.77e-22

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 97.13  E-value: 5.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYkaRNVHTGELAAVKIikLEPGDDFSLIQQ-EIFMVKECKHCNIVAYFGSYL----SREKLWICMEY 96
Cdd:cd14142   9 LVECIGKGRYGEVW--RGQWQGESVAVKI--FSSRDEKSWFREtEIYNTVLLRHENILGFIASDMtsrnSCTQLWLITHY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDiYHVTGPLSELQIAYVCRETLQGLAYLHTK-----GK---MHRDIKGANILLTDHGDVKLADFGVA---AKI 165
Cdd:cd14142  85 HENGSLYD-YLQRTTLDHQEMLRLALSAASGLVHLHTEifgtqGKpaiAHRDLKSKNILVKSNGQCCIADLGLAvthSQE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATI-AKRKSFIGTPYWMAPEV----AAVEKNGGYNQLcDIWAVGITAIELG----------ELQPPMFDLHPMRALFL- 229
Cdd:cd14142 164 TNQLdVGNNPRVGTKRYMAPEVldetINTDCFESYKRV-DIYAFGLVLWEVArrcvsggiveEYKPPFYDVVPSDPSFEd 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 230 MSK----SNFQP--PKlkdktKWSS--TFHNFVKI---ALTKNPKKRPTAERL 271
Cdd:cd14142 243 MRKvvcvDQQRPniPN-----RWSSdpTLTAMAKLmkeCWYQNPSARLTALRI 290
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
18-274 5.90e-22

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 96.25  E-value: 5.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14184   1 EKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIdKAKCCGKEHLIENEVSILRRVKHPNIIMLIEEMDTPAELYLVMEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKITATIAkr 172
Cdd:cd14184  81 VKGGDLFDAITSSTKYTERDASAMVYNLASALKYLHGLCIVHRDIKPENLLVCEYPDgtksLKLGDFGLATVVEGPLY-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVG-ITAIEL---------GELQPPMFDlhpmraLFLMSKSNFQPP---K 239
Cdd:cd14184 159 -TVCGTPTYVAPEIIA---ETGYGLKVDIWAAGvITYILLcgfppfrseNNLQEDLFD------QILLGKLEFPSPywdN 228
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 240 LKDKTKwsstfhNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14184 229 ITDSAK------ELISHMLQVNVEARYTAEQILSH 257
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
24-186 6.96e-22

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 97.06  E-value: 6.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTG----ELAAVKIIklePGDDFSLIQQE--IFMVKECKHCNIVAYFGSYL----SREKLWIC 93
Cdd:cd14055   1 KLVGKGRFAEVWKAKLKQNAsgqyETVAVKIF---PYEEYASWKNEkdIFTDASLKHENILQFLTAEErgvgLDRQYWLI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDiYHVTGPLSELQIAYVCRETLQGLAYLH----TKGKM-----HRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd14055  78 TAYHENGSLQD-YLTRHILSWEDLCKMAGSLARGLAHLHsdrtPCGRPkipiaHRDLKSSNILVKNDGTCVLADFGLALR 156
                       170       180
                ....*....|....*....|....*..
gi 38570135 165 ITATIAkRKSF-----IGTPYWMAPEV 186
Cdd:cd14055 157 LDPSLS-VDELansgqVGTARYMAPEA 182
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
26-280 8.60e-22

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 97.52  E-value: 8.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   26 VGSGTYGDVYKARNVHTGELAAVKIIKL---------------EPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:PTZ00024  17 LGEGTYGKVEKAYDTLTGKIVAIKKVKIieisndvtkdrqlvgMCGIHFTTLR-ELKIMNEIKHENIMGLVDVYVEGDFI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   91 WICMEYCGGgSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK-----I 165
Cdd:PTZ00024  96 NLVMDIMAS-DLKKVVDRKIRLTESQVKCILLQILNGLNVLHKWYFMHRDLSPANIFINSKGICKIADFGLARRygyppY 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  166 TATIAKRK---------SFIGTPYWMAPE-VAAVEKnggYNQLCDIWAVGITAIELgELQPPMF----DLHPM-RALFLM 230
Cdd:PTZ00024 175 SDTLSKDEtmqrreemtSKVVTLWYRAPElLMGAEK---YHFAVDMWSVGCIFAEL-LTGKPLFpgenEIDQLgRIFELL 250
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  231 ---SKSNF-QPPKLKDKTKWSST----FHNFVKIA-----------LTKNPKKRPTAERLLTHT-FVAQP 280
Cdd:PTZ00024 251 gtpNEDNWpQAKKLPLYTEFTPRkpkdLKTIFPNAsddaidllqslLKLNPLERISAKEALKHEyFKSDP 320
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
19-216 1.47e-21

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 95.56  E-value: 1.47e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd07861   1 DYTKIEKIGEGTYGVVYKGRNKKTGQIVAMKKIRLESEEEGvpSTAIREISLLKELQHPNIVCLEDVLMQENRLYLVFEF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 --CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd07861  81 lsMDLKKYLDSLPKGKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTH 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 38570135 175 FIGTPYWMAPEVAAveknGG--YNQLCDIWAVGITAIELGELQP 216
Cdd:cd07861 161 EVVTLWYRAPEVLL----GSprYSTPVDIWSIGTIFAEMATKKP 200
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
20-216 2.22e-21

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 95.14  E-value: 2.22e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP--GDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd07844   2 YKKLDKLGEGSYATVYKGRSKLTGQLVALKEIRLEHeeGAPFTAIR-EASLLKDLKHANIVTLHDIIHTKKTLTLVFEYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-AKITATiakrKSF- 175
Cdd:cd07844  81 DTDLKQYMDDCGGGLSMHNVRLFLFQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLArAKSVPS----KTYs 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 176 --IGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07844 157 neVVTLWYRPPDVLLGSTE--YSTSLDMWGVGCIFYEMATGRP 197
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
19-272 2.32e-21

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 95.27  E-value: 2.32e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVK--IIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREK--LWICM 94
Cdd:cd14049   7 EFEEIARLGKGGYGKVYKVRNKLDGQYYAIKkiLIKKVTKRDCMKVLREVKVLAGLQHPNIVGYHTAWMEHVQlmLYIQM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYC----------------------GGGSLQDIYHVTGPLSELqiayvcretLQGLAYLHTKGKMHRDIKGANILLtdHG 152
Cdd:cd14049  87 QLCelslwdwivernkrpceeefksAPYTPVDVDVTTKILQQL---------LEGVTYIHSMGIVHRDLKPRNIFL--HG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 153 ---DVKLADFGVAAKI-------TATIAKRKSF-----IGTPYWMAPEvaavEKNGG-YNQLCDIWAVGITAIELgeLQP 216
Cdd:cd14049 156 sdiHVRIGDFGLACPDilqdgndSTTMSRLNGLthtsgVGTCLYAAPE----QLEGShYDFKSDMYSIGVILLEL--FQP 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 217 pmFDLHPMRALFLMSKSNFQPPKLKDKtKWsSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd14049 230 --FGTEMERAEVLTQLRNGQIPKSLCK-RW-PVQAKYIKLLTSTEPSERPSASQLL 281
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
19-217 2.99e-21

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 95.85  E-value: 2.99e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKiiklepgddfSLIQQEIFMVKECKHCN-------------IVAYFGSYL 85
Cdd:cd05598   2 MFEKIKTIGVGAFGEVSLVRKKDTNALYAMK----------TLRKKDVLKRNQVAHVKaerdilaeadnewVVKLYYSFQ 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLQDIYHVTG----PLSELQIAyvcrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd05598  72 DKENLYFVMDYIPGGDLMSLLIKKGifeeDLARFYIA----ELVCAIESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL 147
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKR----KSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd05598 148 CTGFRWTHDSKyylaHSLVGTPNYIAPEVLLRT---GYTQLCDWWSVGVILYEMLVGQPP 204
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
27-217 3.64e-21

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 95.53  E-value: 3.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIK----LEPGD-DFSLIQQEIFMVKeCKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05592   4 GKGSFGKVMLAELKGTNQYFAIKALKkdvvLEDDDvECTMIERRVLALA-SQHPFLTHLFCTFQTESHLFFVMEYLNGGD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LqdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTP 179
Cdd:cd05592  83 L--MFHIqqSGRFDEDRARFYGAEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKENIYGENKASTFCGTP 160
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 38570135 180 YWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd05592 161 DYIAPEILKGQK---YNQSVDWWSFGVLLYEMLIGQSP 195
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
28-279 4.31e-21

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 94.27  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  28 SGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREK-----LWICMEYCGGGS 101
Cdd:cd14037  13 EGGFAHVYLVKTSNGGNRAALKRVYVNDEHDLNVCKREIEIMKRLSgHKNIVGYIDSSANRSGngvyeVLLLMEYCKGGG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI- 176
Cdd:cd14037  93 VIDLMnqRLQTGLTESEILKIFCDVCEAVAAMHYLKPplIHRDLKVENVLISDSGNYKLCDFGSATTKILPPQTKQGVTy 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 --------GTPYWMAPEVaaVEKNGG--YNQLCDIWAVGITAIELGELQPPmFDLHPMRAlflMSKSNFQPPklkDKTKW 246
Cdd:cd14037 173 veedikkyTTLQYRAPEM--IDLYRGkpITEKSDIWALGCLLYKLCFYTTP-FEESGQLA---ILNGNFTFP---DNSRY 243
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14037 244 SKRLHKLIRYMLEEDPEKRPNIYQVSYEAFELA 276
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
18-228 4.65e-21

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 95.38  E-value: 4.65e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQ--EIFMVKE------CKHCNIVAYFGSYLSREK 89
Cdd:cd05619   5 EDFVLHKMLGKGSFGKVFLAELKGTNQFFAIKALK----KDVVLMDDdvECTMVEKrvlslaWEHPFLTHLFCTFQTKEN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLqdIYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05619  81 LFFVMEYLNGGDL--MFHIQSchKFDLPRATFYAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135 168 TIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF 228
Cdd:cd05619 159 GDAKTSTFCGTPDYIAPEILLGQK---YNTSVDWWSFGVLLYEMLIGQSP-FHGQDEEELF 215
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
19-276 5.42e-21

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 93.06  E-value: 5.42e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHT-------GELAAVKiiKLEPGDDFSLIQQEIFMVKECKHC-NIVAYFGSYLSREKL 90
Cdd:cd14019   2 KYRIIEKIGEGTFSSVYKAEDKLHdlydrnkGRLVALK--HIYPTSSPSRILNELECLERLGGSnNVSGLITAFRNEDQV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDIYHvTGPLSELQIaYVcRETLQGLAYLHTKGKMHRDIKGANILL---TDHGdvKLADFGVAAKITA 167
Cdd:cd14019  80 VAVLPYIEHDDFRDFYR-KMSLTDIRI-YL-RNLFKALKHVHSFGIIHRDVKPGNFLYnreTGKG--VLVDFGLAQREED 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEVaaVEKNGgyNQLC--DIWAVGITAIE-LGELQPPMFDLHPMRALF-LMSksnfqppklkdK 243
Cdd:cd14019 155 RPEQRAPRAGTRGFRAPEV--LFKCP--HQTTaiDIWSAGVILLSiLSGRFPFFFSSDDIDALAeIAT-----------I 219
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 244 TKWSSTFHnFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14019 220 FGSDEAYD-LLDKLLELDPSKRITAEEALKHPF 251
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
20-206 6.25e-21

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 93.17  E-value: 6.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS--LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14075   4 YRIRGELGSGNFSQVKLGIHQLTKEKVAIKILDKTKLDQKTqrLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKR----K 173
Cdd:cd14075  84 SGGELYTKISTEGKLSESEAKPLFAQIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGF-----STHAKRgetlN 158
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 174 SFIGTPYWMAPEVAAVEKNGGynQLCDIWAVGI 206
Cdd:cd14075 159 TFCGSPPYAAPELFKDEHYIG--IYVDIWALGV 189
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
19-274 8.25e-21

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 93.26  E-value: 8.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELA-AVKIIKLEPGD--DFSLIQQEIFMVKECK---HCNIVAYFGSYLSREKLWI 92
Cdd:cd14052   1 RFANVELIGSGEFSQVYKVSERVPTGKVyAVKKLKPNYAGakDRLRRLEEVSILRELTldgHDNIVQLIDSWEYHGHLYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQ---DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAti 169
Cdd:cd14052  81 QTELCENGSLDvflSELGLLGRLDEFRVWKILVELSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGMATVWPL-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 170 AKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL-GELQPP-------------MFDLHPMRALFLMSKSNF 235
Cdd:cd14052 159 IRGIEREGDREYIAPEILS---EHMYDKPADIFSLGLILLEAaANVVLPdngdawqklrsgdLSDAPRLSSTDLHSASSP 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 38570135 236 Q---PPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14052 236 SsnpPPDPPNMPILSGSLDRVVRWMLSPEPDRRPTADDVLAT 277
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
18-219 9.59e-21

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 93.54  E-value: 9.59e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07871   5 ETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEheEGAPCTAIR-EVSLLKNLKHANIVTLHDIIHTERCLTLVFE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd07871  84 YLDSDLKQYLDNCGNLMSMHNVKIFMFQLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNE 163
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 176 IGTPYWMAPEV--AAVEknggYNQLCDIWAVGITAIELGELQpPMF 219
Cdd:cd07871 164 VVTLWYRPPDVllGSTE----YSTPIDMWGVGCILYEMATGR-PMF 204
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
20-219 1.66e-20

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 92.96  E-value: 1.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:PLN00009   4 YEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEQEDEGvpSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   98 gGGSLQDIYHVTGPLSELQ--IAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD-VKLADFGVAAKITATIAKRKS 174
Cdd:PLN00009  84 -DLDLKKHMDSSPDFAKNPrlIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNaLKLADFGLARAFGIPVRTFTH 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 38570135  175 FIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGElQPPMF 219
Cdd:PLN00009 163 EVVTLWYRAPEILLGSRH--YSTPVDIWSVGCIFAEMVN-QKPLF 204
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
24-367 1.67e-20

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 93.43  E-value: 1.67e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05590   1 RVLGKGSFGKVMLARLKESGRLYAVKVLKkdviLQDDDVECTMTEKRILSLARNHPFLTQLYCCFQTPDRLFFVMEFVNG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177
Cdd:cd05590  81 GDL--MFHIQKSrrFDEARARFYAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIFNGKTTSTFCG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFlmsksnfqPPKLKDKTKWSSTFH----NF 253
Cdd:cd05590 159 TPDYIAPEILQEML---YGPSVDWWAMGVLLYEMLCGHAP-FEAENEDDLF--------EAILNDEVVYPTWLSqdavDI 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 254 VKIALTKNPKKRPTAerllthtfVAQPGlsralavelldkvnnpdnhahyteaddddfePHAIIRHTIrstnrnaraert 333
Cdd:cd05590 227 LKAFMTKNPTMRLGS--------LTLGG-------------------------------EEAILRHPF------------ 255
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 38570135 334 ASEINFDKL---QFEPPLRKETEARDEMGlSSDPNFM 367
Cdd:cd05590 256 FKELDWEKLnrrQIEPPFRPRIKSREDVS-NFDPDFI 291
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
16-206 1.88e-20

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 91.64  E-value: 1.88e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKArnVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKeCKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05039   4 NKKDLKLGELIGKGEFGDVMLG--DYRGQKVAVKCLKDDSTAAQAFLAEASVMTT-LRHPNLVQLLGVVLEGNGLYIVTE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDI------YHVTGplsELQIAYvCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd05039  81 YMAKGSLVDYlrsrgrAVITR---KDQLGF-ALDVCEGMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFGLAKEASSNQ 156
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 38570135 170 AKRKSFIGtpyWMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd05039 157 DGGKLPIK---WTAPEAL---REKKFSTKSDVWSFGI 187
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
26-211 1.96e-20

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 92.19  E-value: 1.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14154   1 LGKGFFGQAIKVTHRETGEVMVMKeLIRFDEEAQRNFLK-EVKVMRSLDHPNVLKFIGVLYKDKKLNLITEYIPGGTLKD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYH-VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA--------------------A 163
Cdd:cd14154  80 VLKdMARPLPWAQRVRFAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLArliveerlpsgnmspsetlrH 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 164 KITATIAKRKSFIGTPYWMAPEVAavekNG-GYNQLCDIWAVGITAIEL 211
Cdd:cd14154 160 LKSPDRKKRYTVVGNPYWMAPEML----NGrSYDEKVDIFSFGIVLCEI 204
STKc_ROCK cd05596
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
12-211 2.73e-20

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK is also referred to as Rho-associated kinase or simply as Rho kinase. It contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain. It is activated via interaction with Rho GTPases and is involved in many cellular functions including contraction, adhesion, migration, motility, proliferation, and apoptosis. The ROCK subfamily consists of two isoforms, ROCK1 and ROCK2, which may be functionally redundant in some systems, but exhibit different tissue distributions. Both isoforms are ubiquitously expressed in most tissues, but ROCK2 is more prominent in brain and skeletal muscle while ROCK1 is more pronounced in the liver, testes, and kidney. Studies in knockout mice result in different phenotypes, suggesting that the two isoforms do not compensate for each other during embryonic development. The ROCK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270747 [Multi-domain]  Cd Length: 352  Bit Score: 93.21  E-value: 2.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  12 LRRNPQqDYELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLE----PGDDFSLIQQEIfMVkeckHCN---IVAYFGS 83
Cdd:cd05596  21 LRMNAE-DFDVIKVIGRGAFGEVQLVRHKSTKKVYAMKLLsKFEmikrSDSAFFWEERDI-MA----HANsewIVQLHYA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  84 YLSREKLWICMEYCGGG---SLQDIYHVTgplsELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG 160
Cdd:cd05596  95 FQDDKYLYMVMDYMPGGdlvNLMSNYDVP----EKWARFYTAEVVLALDAIHSMGFVHRDVKPDNMLLDASGHLKLADFG 170
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 161 VAAKITAT-IAKRKSFIGTPYWMAPEV-AAVEKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05596 171 TCMKMDKDgLVRSDTAVGTPDYISPEVlKSQGGDGVYGRECDWWSVGVFLYEM 223
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
26-270 3.52e-20

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 91.73  E-value: 3.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnvHTGELAAVKIIKLEpgDDFSLIQQ-EIFMVKECKHCNIVAYFGS----YLSREKLWICMEYCGGG 100
Cdd:cd13998   3 IGKGRFGEVWKAS--LKNEPVAVKIFSSR--DKQSWFREkEIYRTPMLKHENILQFIAAderdTALRTELWLVTAFHPNG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDiYHVTGPLSELQIAYVCRETLQGLAYLH------TKGK---MHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd13998  79 SL*D-YLSLHTIDWVSLCRLALSVARGLAHLHseipgcTQGKpaiAHRDLKSKNILVKNDGTCCIADFGLAVRLSPSTGE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 ----RKSFIGTPYWMAPEV----AAVEKNGGYNQLcDIWAVGITAIELG-----------ELQPPMFD---LHP----MR 225
Cdd:cd13998 158 ednaNNGQVGTKRYMAPEVlegaINLRDFESFKRV-DIYAMGLVLWEMAsrctdlfgiveEYKPPFYSevpNHPsfedMQ 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 226 ALFLMSKsnfQPPKLKDKTKWSSTFHNFVKI---ALTKNPKKRPTAER 270
Cdd:cd13998 237 EVVVRDK---QRPNIPNRWLSHPGLQSLAETieeCWDHDAEARLTAQC 281
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
26-211 3.61e-20

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 91.04  E-value: 3.61e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPgdDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14156   1 IGSGFFSKVYKVTHGATGKVMVVKIYKNDV--DQHKIVREISLLQKLSHPNIVRYLGICVKDEKLHPILEYVSGGCLEEL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVK---LADFGVAAKITATIAK---RK-SFIG 177
Cdd:cd14156  79 LAREElPLSWREKVELACDISRGMVYLHSKNIYHRDLNSKNCLIRVTPRGReavVTDFGLAREVGEMPANdpeRKlSLVG 158
                       170       180       190
                ....*....|....*....|....*....|....
gi 38570135 178 TPYWMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd14156 159 SAFWMAPEMLRGEP---YDRKVDVFSFGIVLCEI 189
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
23-273 4.60e-20

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 91.42  E-value: 4.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRV-GSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGS-YLSRE-------KLWI 92
Cdd:cd14036   4 IKRViAEGGFAFVYEAQDVGTGKEYALKrLLSNEEEKNKAIIQEINFMKKLSGHPNIVQFCSAaSIGKEesdqgqaEYLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQDIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd14036  84 LTELCKGQLVDFVKKVEapGPFSPDTVLKIFYQTCRAVQHMHKQSPpiIHRDLKIENLLIGNQGQIKLCDFGSATTEAHY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 -----IAKRKSFI-------GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALflmsKSNFQ 236
Cdd:cd14036 164 pdyswSAQKRSLVedeitrnTTPMYRTPEMIDLYSNYPIGEKQDIWALGCILYLLCFRKHPFEDGAKLRII----NAKYT 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 237 PPklKDKTKWsSTFHNFVKIALTKNPKKRPTAERLLT 273
Cdd:cd14036 240 IP--PNDTQY-TVFHDLIRSTLKVNPEERLSITEIVE 273
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
20-277 5.38e-20

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 90.82  E-value: 5.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP--GDDfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14183   8 YKVGRTIGDGNFAVVKECVERSTGREYALKIINKSKcrGKE-HMIQNEVSILRRVKHPNIVLLIEEMDMPTELYLVMELV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKITATIAkrk 173
Cdd:cd14183  87 KGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDgsksLKLGDFGLATVVDGPLY--- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVG-ITAIELGELQPPMFDLHPMRALF---LMSKSNFQPPKLKDKtkwSST 249
Cdd:cd14183 164 TVCGTPTYVAPEIIA---ETGYGLKVDIWAAGvITYILLCGFPPFRGSGDDQEVLFdqiLMGQVDFPSPYWDNV---SDS 237
                       250       260
                ....*....|....*....|....*...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14183 238 AKELITMMLQVDVDQRYSALQVLEHPWV 265
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
18-278 5.46e-20

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 92.25  E-value: 5.46e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05610   4 EEFVIVKPISRGAFGKVYLGRKKNNSKLYAVKVVKKADMINKNMVHQvqaERDALALSKSPFIVHLYYSLQSANNVYLVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKI--------- 165
Cdd:cd05610  84 EYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGL-SKVtlnrelnmm 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 ----TATIAKRKS-----------------------------------------FIGTPYWMAPEVAAVEKNGgynQLCD 200
Cdd:cd05610 163 diltTPSMAKPKNdysrtpgqvlslisslgfntptpyrtpksvrrgaarvegerILGTPDYLAPELLLGKPHG---PAVD 239
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38570135 201 IWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPklKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd05610 240 WWALGVCLFEFLTGIPPFNDETPQQVFQNILNRDIPWP--EGEEELSVNAQNAIEILLTMDPTKRAGLKELKQHPLFH 315
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
19-219 5.55e-20

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 90.93  E-value: 5.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK-----LEPGDDFSLIQQEIFMVKEckhcN--IVAYFGSYLSREKLW 91
Cdd:cd05609   1 DFETIKLISNGAYGAVYLVRHRETRQRFAMKKINkqnliLRNQIQQVFVERDILTFAE----NpfVVSMYCSFETKRHLC 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLS-ELQIAYVCrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKI----- 165
Cdd:cd05609  77 MVMEYVEGGDCATLLKNIGPLPvDMARMYFA-ETVLALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGL-SKIglmsl 154
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 166 -----------TATIAKRKSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMF 219
Cdd:cd05609 155 ttnlyeghiekDTREFLDKQVCGTPEYIAPEVILRQ---GYGKPVDWWAMGIILYEFLVGCVPFF 216
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
26-219 5.82e-20

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 91.95  E-value: 5.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05603   3 IGKGSFGKVLLAKRKCDGKFYAVKVLQkktiLKKKEQNHIMAERNVLLKNLKHPFLVGLHYSFQTSEKLYFVLDYVNGGE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTP 179
Cdd:cd05603  83 L--FFHLQRErcFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGMEPEETTSTFCGTP 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 180 YWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMF 219
Cdd:cd05603 161 EYLAPEVLRKEP---YDRTVDWWCLGAVLYEMLYGLPPFY 197
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
20-220 5.90e-20

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 90.47  E-value: 5.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14088   3 YDLGQVIKTEEFCEIFRAKDKTTGKLYTCKKFLKRDGRKVrKAAKNEINILKMVKHPNILQLVDVFETRKEYFIFLELAT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD---HGDVKLADFGVAAKITATIakrKSF 175
Cdd:cd14088  83 GREVFDWILDQGYYSERDTSNVIRQVLEAVAYLHSLKIVHRNLKLENLVYYNrlkNSKIVISDFHLAKLENGLI---KEP 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 176 IGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFD 220
Cdd:cd14088 160 CGTPEYLAPEVVGRQR---YGRPVDCWAIGVIMYILLSGNPPFYD 201
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
20-216 8.02e-20

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 90.66  E-value: 8.02e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD---------FSLIQ---QEIFMVK--------ECKHCNIVA 79
Cdd:cd07837   3 YEKLEKIGEGTYGKVYKARDKNTGKLVALKKTRLEMEEEgvpstalreVSLLQmlsQSIYIVRlldvehveENGKPLLYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  80 YFgSYLSRE-KLWICMEYCGGGSlqdiyhvtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLA 157
Cdd:cd07837  83 VF-EYLDTDlKKFIDSYGRGPHN---------PLPAKTIQSFMYQLCKGVAHCHSHGVMHRDLKPQNLLVdKQKGLLKIA 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 158 DFGVAAKITATIAKRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07837 153 DLGLGRAFTIPIKSYTHEIVTLWYRAPEV--LLGSTHYSTPVDMWSVGCIFAEMSRKQP 209
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
26-318 8.82e-20

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 91.19  E-value: 8.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCNIVAYfgSYLSREKLWICMEYCGGG 100
Cdd:cd05632  10 LGKGGFGEVCACQVRATGKMYACKRlekkrIKKRKGESMALNEKQILEKVNSQFVVNLAY--AYETKDALCLVLTIMNGG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSfIGT 178
Cdd:cd05632  88 DLKfHIYNMGNPgFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGESIRGR-VGT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 179 PYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRalflMSKSNFQPPKLKDKTKWSSTF----HNFV 254
Cdd:cd05632 167 VGYMAPEVL---NNQRYTLSPDYWGLGCLIYEMIEGQSP-FRGRKEK----VKREEVDRRVLETEEVYSAKFseeaKSIC 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 255 KIALTKNPKKR-----PTAERLLTHTFVAQPGLSRaLAVELLDKVNNPDNHAHYTEaDDDDFEPHAIIR 318
Cdd:cd05632 239 KMLLTKDPKQRlgcqeEGAGEVKRHPFFRNMNFKR-LEAGMLDPPFVPDPRAVYCK-DVLDIEQFSTVK 305
STKc_NDR2 cd05627
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze ...
19-223 8.85e-20

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR2 (also called STK38-like) plays a role in proper centrosome duplication. In addition, it is involved in regulating neuronal growth and differentiation, as well as in facilitating neurite outgrowth. NDR2 is also implicated in fear conditioning as it contributes to the coupling of neuronal morphological changes with fear-memory consolidation. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270776 [Multi-domain]  Cd Length: 366  Bit Score: 92.04  E-value: 8.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK---LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05627   3 DFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRkadMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIME 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT------- 168
Cdd:cd05627  83 FLPGGDMMTLLMKKDTLSEEATQFYIAETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAhrtefyr 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 ---------------IAKRK-------------SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFD 220
Cdd:cd05627 163 nlthnppsdfsfqnmNSKRKaetwkknrrqlaySTVGTPDYIAPEVFM---QTGYNKLCDWWSLGVIMYEMLIGYPPFCS 239

                ...
gi 38570135 221 LHP 223
Cdd:cd05627 240 ETP 242
STKc_ROCK2 cd05621
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
18-211 9.55e-20

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2 was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270771 [Multi-domain]  Cd Length: 379  Bit Score: 92.37  E-value: 9.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05621  52 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLsKFEmiKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVM 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHvTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT-IAKRK 173
Cdd:cd05621 132 EYMPGGDLVNLMS-NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCMKMDETgMVHCD 210
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 38570135 174 SFIGTPYWMAPEVAAVEKNGG-YNQLCDIWAVGITAIEL 211
Cdd:cd05621 211 TAVGTPDYISPEVLKSQGGDGyYGRECDWWSVGVFLFEM 249
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
26-265 1.23e-19

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 91.01  E-value: 1.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK----LEPGD-DFSLIQQEIfMVKECKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd05591   3 LGKGSFGKVMLAERKGTDEVYAIKVLKkdviLQDDDvDCTMTEKRI-LALAAKHPFLTALHSCFQTKDRLFFVMEYVNGG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Cdd:cd05591  82 DLMFQIQRARKFDEPRARFYAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGKTTTTFCGTPD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 WMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALF--LMSKSNFQPPKLkdktkwSSTFHNFVKIAL 258
Cdd:cd05591 162 YIAPEIL---QELEYGPSVDWWALGVLMYEMMAGQPP-FEADNEDDLFesILHDDVLYPVWL------SKEAVSILKAFM 231

                ....*..
gi 38570135 259 TKNPKKR 265
Cdd:cd05591 232 TKNPAKR 238
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
27-272 1.23e-19

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 88.86  E-value: 1.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTG-ELAAVKIIKLEPgddfsliQQEIFMVkeCKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDi 105
Cdd:cd14060   2 GGGSFGSVYRAIWVSQDkEVAVKKLLKIEK-------EAEILSV--LSHRNIIQFYGAILEAPNYGIVTEYASYGSLFD- 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YHVTGPLSELQIAYV---CRETLQGLAYLHTKGKM---HRDIKGANILLTDHGDVKLADFGVAAKITATIakRKSFIGTP 179
Cdd:cd14060  72 YLNSNESEEMDMDQImtwATDIAKGMHYLHMEAPVkviHRDLKSRNVVIAADGVLKICDFGASRFHSHTT--HMSLVGTF 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 180 YWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPpklkdkTKWSS---TFHNFVKI 256
Cdd:cd14060 150 PWMAPEVI---QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERP------TIPSScprSFAELMRR 220
                       250
                ....*....|....*.
gi 38570135 257 ALTKNPKKRPTAERLL 272
Cdd:cd14060 221 CWEADVKERPSFKQII 236
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
26-265 1.40e-19

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 90.79  E-value: 1.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05604   4 IGKGSFGKVLLAKRKRDGKYYAVKVLQkkviLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTDKLYFVLDFVNGGE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTP 179
Cdd:cd05604  84 L--FFHLQRErsFPEPRARFYAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEGISNSDTTTTFCGTP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 180 YWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFQPPklKDKTKWSstfhnFVKIA 257
Cdd:cd05604 162 EYLAPEVIRKQP---YDNTVDWWCLGSVLYEMLYGLPPFYcrDTAEMYENILHKPLVLRPG--ISLTAWS-----ILEEL 231

                ....*...
gi 38570135 258 LTKNPKKR 265
Cdd:cd05604 232 LEKDRQLR 239
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
20-274 1.42e-19

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 90.19  E-value: 1.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVH-TGELAAVKII-KLEPGDDFSL------IQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd14096   3 YRLINKIGEGAFSNVYKAVPLRnTGKPVAIKVVrKADLSSDNLKgssranILKEVQIMKRLSHPNIVKLLDFQESDEYYY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQD-IYHVTgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT--------------------- 149
Cdd:cd14096  83 IVLELADGGEIFHqIVRLT-YFSEDLSRHVITQVASAVKYLHEIGVVHRDIKPENLLFEpipfipsivklrkadddetkv 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 150 DHGD------------VKLADFGVAAKITATIAKRKSfiGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd14096 162 DEGEfipgvggggigiVKLADFGLSKQVWDSNTKTPC--GTVGYTAPEVVKDER---YSKKVDMWALGCVLYTLLCGFPP 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 218 MFDLHPMRALFLMSKSN--FQPPklkdktkW----SSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14096 237 FYDESIETLTEKISRGDytFLSP-------WwdeiSKSAKDLISHLLTVDPAKRYDIDEFLAH 292
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
18-206 1.42e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 90.32  E-value: 1.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQR---VGSGTYGDVYKARNVHTGELAAVKII--KLEpgddfSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLW 91
Cdd:cd14180   3 QCYELDLEepaLGEGSFSVCRKCRHRQSGQEYAVKIIsrRME-----ANTQREVAALRLCQsHPNIVALHEVLHDQYHTY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITAT 168
Cdd:cd14180  78 LVMELLRGGELLDRIKKKARFSESEASQLMRSLVSAVSFMHEAGVVHRDLKPENILYADESDgavLKVIDFGFARLRPQG 157
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 38570135 169 IAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGI 206
Cdd:cd14180 158 SRPLQTPCFTLQYAAPELFS---NQGYDESCDLWSLGV 192
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
18-277 1.47e-19

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 89.28  E-value: 1.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRV-GSGTYGDVYKARNVHTGELAAVKIIKLEPGddfslIQQEI---FMVKECKH--CNIVAYFGSYLSREKLW 91
Cdd:cd14172   3 DDYKLSKQVlGLGVNGKVLECFHRRTGQKCALKLLYDSPK-----ARREVehhWRASGGPHivHILDVYENMHHGKRCLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---DHGDVKLADFGVAAKIT 166
Cdd:cd14172  78 IIMECMEGGELFSRIQERGdqAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLYTskeKDAVLKLTDFGFAKETT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKSFIgTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFD-----LHP-MRALFLMSKSNFQPPKL 240
Cdd:cd14172 158 VQNALQTPCY-TPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGFPPFYSntgqaISPgMKRRIRMGQYGFPNPEW 233
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 241 KDKtkwSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14172 234 AEV---SEEAKQLIRHLLKTDPTERMTITQFMNHPWI 267
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
20-276 1.49e-19

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 89.64  E-value: 1.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQ-----EIFMVKECK-HCNIVAYFGSYLSRE--KLW 91
Cdd:cd07831   1 YKILGKIGEGTFSEVLKAQSRKTGKYYAIKCMK----KHFKSLEQvnnlrEIQALRRLSpHPNILRLIEVLFDRKtgRLA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEycgggsLQD--IYHVT----GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDhGDVKLADFGVAaki 165
Cdd:cd07831  77 LVFE------LMDmnLYELIkgrkRPLPEKRVKNYMYQLLKSLDHMHRNGIFHRDIKPENILIKD-DILKLADFGSC--- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 tATIAKRKSF---IGTPYWMAPEvaAVEKNGGYNQLCDIWAVGITAIELGELQpPMF----------DLH-----PMRAL 227
Cdd:cd07831 147 -RGIYSKPPYteyISTRWYRAPE--CLLTDGYYGPKMDIWAVGCVFFEILSLF-PLFpgtneldqiaKIHdvlgtPDAEV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 228 FLM----SKSNFQPPKLKDK------TKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd07831 223 LKKfrksRHMNYNFPSKKGTglrkllPNASAEGLDLLKKLLAYDPDERITAKQALRHPY 281
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
19-277 1.90e-19

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 89.15  E-value: 1.90e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14117   7 DFDIGRPLGKGKFGNVYLAREKQSKFIVALKVLfksQIEKEGVEHQLRREIEIQSHLRHPNILRLYNYFHDRKRIYLILE 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAakITATIAKRKSF 175
Cdd:cd14117  87 YAPRGELYKELQKHGRFDEQRTATFMEELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ-PPKLKDKTKwsstfhNFV 254
Cdd:cd14117 165 CGTLDYLPPEMI---EGRTHDEKVDLWCIGVLCYELLVGMPPFESASHTETYRRIVKVDLKfPPFLSDGSR------DLI 235
                       250       260
                ....*....|....*....|...
gi 38570135 255 KIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14117 236 SKLLRYHPSERLPLKGVMEHPWV 258
STKc_NDR1 cd05628
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze ...
18-223 2.29e-19

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR1 (also called STK38) plays a role in proper centrosome duplication. It is highly expressed in thymus, muscle, lung and spleen. It is not an essential protein because mice deficient of NDR1 remain viable and fertile. However, these mice develop T-cell lymphomas and appear to be hypersenstive to carcinogenic treatment. NDR1 appears to also act as a tumor suppressor. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270777 [Multi-domain]  Cd Length: 376  Bit Score: 90.87  E-value: 2.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK---LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05628   1 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRkadMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA------------ 162
Cdd:cd05628  81 EFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCtglkkahrtefy 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 -----------------AKITATIAKRK------SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMF 219
Cdd:cd05628 161 rnlnhslpsdftfqnmnSKRKAETWKRNrrqlafSTVGTPDYIAPEVFM---QTGYNKLCDWWSLGVIMYEMLIGYPPFC 237

                ....
gi 38570135 220 DLHP 223
Cdd:cd05628 238 SETP 241
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
15-219 2.33e-19

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 90.46  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQ---QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSR 87
Cdd:cd05602   1 NPHakpSDFHFLKVIGKGSFGKVLLARHKSDEKFYAVKVLQkkaiLKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGGSLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI 165
Cdd:cd05602  81 DKLYFVLDYINGGEL--FYHLQRErcFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKEN 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 38570135 166 TATIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMF 219
Cdd:cd05602 159 IEPNGTTSTFCGTPEYLAPEVLHKQP---YDRTVDWWCLGAVLYEMLYGLPPFY 209
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
27-276 2.99e-19

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 88.60  E-value: 2.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNV---HTGELAAVKIIKlepgdDFSLIQ------------QEIFMVKECKHcnIVAYFGSYLSREKLW 91
Cdd:cd05583   3 GTGAYGKVFLVRKVgghDAGKLYAMKVLK-----KATIVQkaktaehtmterQVLEAVRQSPF--LVTLHYAFQTDAKLH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd05583  76 LILDYVNGGELFTHLYQREHFTESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFLPGEND 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RK-SFIGTPYWMAPEVAAvEKNGGYNQLCDIWAVGITAIEL----------GE-------------LQPPMfdlhpmral 227
Cdd:cd05583 156 RAySFCGTIEYMAPEVVR-GGSDGHDKAVDWWSLGVLTYELltgaspftvdGErnsqseiskrilkSHPPI--------- 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 38570135 228 flmsksnfqPPKLkdktkwSSTFHNFVKIALTKNPKKR-----PTAERLLTHTF 276
Cdd:cd05583 226 ---------PKTF------SAEAKDFILKLLEKDPKKRlgagpRGAHEIKEHPF 264
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
26-276 3.04e-19

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 88.52  E-value: 3.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTG------ELAAVKIIKLEPgDDFSliqQEIFMVKECKHCNIVAYFGSYLSREKLWICM----E 95
Cdd:cd14033   9 IGRGSFKTVYRGLDTETTvevawcELQTRKLSKGER-QRFS---EEVEMLKGLQHPNIVRFYDSWKSTVRGHKCIilvtE 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTD-HGDVKLADFGVAAKITATIAKr 172
Cdd:cd14033  85 LMTSGTLKTYLKRFREMKLKLLQRWSRQILKGLHFLHSRCPpiLHRDLKCDNIFITGpTGSVKIGDLGLATLKRASFAK- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVAAvEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQP--------PKLKDkt 244
Cdd:cd14033 164 -SVIGTPEFMAPEMYE-EK---YDEAVDVYAFGMCILEMATSEYPYSECQNAAQIYRKVTSGIKPdsfykvkvPELKE-- 236
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 245 kwsstfhnFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14033 237 --------IIEGCIRTDKDERFTIQDLLEHRF 260
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
26-211 3.27e-19

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 88.43  E-value: 3.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD- 104
Cdd:cd14193  12 LGGGRFGQVHKCEEKSSGLKLAAKIIKARSQKEKEEVKNEIEVMNQLNHANLIQLYDAFESRNDIVLVMEYVDGGELFDr 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT--DHGDVKLADFGVAAKITATIAKRKSFiGTPYWM 182
Cdd:cd14193  92 IIDENYNLTELDTILFIKQICEGIQYMHQMYILHLDLKPENILCVsrEANQVKIIDFGLARRYKPREKLRVNF-GTPEFL 170
                       170       180       190
                ....*....|....*....|....*....|
gi 38570135 183 APEVAavekNGGYNQL-CDIWAVGITAIEL 211
Cdd:cd14193 171 APEVV----NYEFVSFpTDMWSLGVIAYML 196
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
18-216 3.60e-19

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 89.28  E-value: 3.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07872   6 ETYIKLEKLGEGTYATVFKGRSKLTENLVALKEIRLEheEGAPCTAIR-EVSLLKDLKHANIVTLHDIVHTDKSLTLVFE 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd07872  85 YLDKDLKQYMDDCGNIMSMHNVKIFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 38570135 176 IGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07872 165 VVTLWYRPPDV--LLGSSEYSTQIDMWGVGCIFFEMASGRP 203
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
18-211 4.00e-19

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 88.16  E-value: 4.00e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYkaRNVHTGELAAVKIIKLEPGDDFSL----IQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd14147   3 QELRLEEVIGIGGFGKVY--RGSWRGELVAVKAARQDPDEDISVtaesVRQEARLFAMLAHPNIIALKAVCLEEPNLCLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIY-------HVTGPLSeLQIAyvcretlQGLAYLHTKG---KMHRDIKGANILLT--------DHGDVK 155
Cdd:cd14147  81 MEYAAGGPLSRALagrrvppHVLVNWA-VQIA-------RGMHYLHCEAlvpVIHRDLKSNNILLLqpienddmEHKTLK 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 156 LADFGVAAKITATiaKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14147 153 ITDFGLAREWHKT--TQMSAAGTYAWMAPEVI---KASTFSKGSDVWSFGVLLWEL 203
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
18-216 4.29e-19

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 88.91  E-value: 4.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07873   2 ETYIKLDKLGEGTYATVYKGRSKLTDNLVALKEIRLEheEGAPCTAIR-EVSLLKDLKHANIVTLHDIIHTEKSLTLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd07873  81 YLDKDLKQYLDDCGNSINMHNVKLFLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 38570135 176 IGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07873 161 VVTLWYRPPDI--LLGSTDYSTQIDMWGVGCIFYEMSTGRP 199
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
26-262 5.88e-19

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 87.88  E-value: 5.88e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIF-MVKECKHCN-IVAYFGSYLSREKLWICMEYCG 98
Cdd:cd05606   2 IGRGGFGEVYGCRKADTGKMYAMKCldkkrIKMKQGETLALNERIMLsLVSTGGDCPfIVCMTYAFQTPDKLCFILDLMN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQdiYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKSFI 176
Cdd:cd05606  82 GGDLH--YHLSqhGVFSEAEMRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVaaVEKNGGYNQLCDiWavgitaielgelqppmFDLHPMRALFLMSKSNFQPPKLKDKtkwsstfHNFVKI 256
Cdd:cd05606 158 GTHGYMAPEV--LQKGVAYDSSAD-W----------------FSLGCMLYKLLKGHSPFRQHKTKDK-------HEIDRM 211

                ....*.
gi 38570135 257 ALTKNP 262
Cdd:cd05606 212 TLTMNV 217
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
26-279 7.36e-19

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 87.47  E-value: 7.36e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTG------ELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM----E 95
Cdd:cd14031  18 LGRGAFKTVYKGLDTETWvevawcELQDRKLTKAEQ----QRFKEEAEMLKGLQHPNIVRFYDSWESVLKGKKCIvlvtE 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTD-HGDVKLADFGVAAKITATIAKr 172
Cdd:cd14031  94 LMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPpiIHRDLKCDNIFITGpTGSVKIGDLGLATLMRTSFAK- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVaaVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTkwSSTFHN 252
Cdd:cd14031 173 -SVIGTPEFMAPEM--YEEH--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVT--DPEVKE 245
                       250       260
                ....*....|....*....|....*..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14031 246 IIEGCIRQNKSERLSIKDLLNHAFFAE 272
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
18-206 7.52e-19

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 88.44  E-value: 7.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDdFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd05599   1 EDFEPLKVIGRGAFGEVRLVRKKDTGHVYAMKKLRksemLEKEQ-VAHVRAERDILAEADNPWVVKLYYSFQDEENLYLI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSL------QDIyhvtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05599  80 MEFLPGGDMmtllmkKDT------LTEEETRFYIAETVLAIESIHKLGYIHRDIKPDNLLLDARGHIKLSDFGLCTGLKK 153
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 38570135 168 TIaKRKSFIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGI 206
Cdd:cd05599 154 SH-LAYSTVGTPDYIAPEV--FLQK-GYGKECDWWSLGV 188
STKc_ROCK1 cd05622
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
14-211 7.60e-19

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270772 [Multi-domain]  Cd Length: 405  Bit Score: 89.68  E-value: 7.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd05622  69 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLsKFEmiKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYL 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDI---YHVTGPLSELQIAyvcrETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05622 149 YMVMEYMPGGDLVNLmsnYDVPEKWARFYTA----EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNK 224
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 168 T-IAKRKSFIGTPYWMAPEVAAVEKNGG-YNQLCDIWAVGITAIEL 211
Cdd:cd05622 225 EgMVRCDTAVGTPDYISPEVLKSQGGDGyYGRECDWWSVGVFLYEM 270
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
27-268 7.76e-19

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 87.67  E-value: 7.76e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARnvHTGELAAVKIIKLEP---------------------GDDFSLIQQEIFMVKECKHCNIVAYFGsyL 85
Cdd:cd14000   3 GDGGFGSVYRAS--YKGEPVAVKIFNKHTssnfanvpadtmlrhlratdaMKNFRLLRQELTVLSHLHHPSIVYLLG--I 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLQDI-------YHVTGPLSELQIAYvcrETLQGLAYLHTKGKMHRDIKGANILL-----TDHGD 153
Cdd:cd14000  79 GIHPLMLVLELAPLGSLDHLlqqdsrsFASLGRTLQQRIAL---QVADGLRYLHSAMIIYRDLKSHNVLVwtlypNSAII 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 154 VKLADFGVAAKITATIAkrKSFIGTPYWMAPEVAavEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS 233
Cdd:cd14000 156 IKIADYGISRQCCRMGA--KGSEGTPGFRAPEIA--RGNVIYNEKVDVFSFGMLLYEILSGGAPMVGHLKFPNEFDIHGG 231
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 234 NFQPPKLKDKTKWSSTfHNFVKIALTKNPKKRPTA 268
Cdd:cd14000 232 LRPPLKQYECAPWPEV-EVLMKKCWKENPQQRPTA 265
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
19-272 8.11e-19

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 88.57  E-value: 8.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCN-IVAYFGSYLSREKLWI 92
Cdd:cd14223   1 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCldkkrIKMKQGETLALNERIMLSLVSTGDCPfIVCMSYAFHTPDKLSF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQdiYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATia 170
Cdd:cd14223  81 ILDLMNGGDLH--YHLSqhGVFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSKK-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELgelqppmfdlhpmralfLMSKSNFQPPKLKDKTKWSS-T 249
Cdd:cd14223 157 KPHASVGTHGYMAPEV--LQKGVAYDSSADWFSLGCMLFKL-----------------LRGHSPFRQHKTKDKHEIDRmT 217
                       250       260
                ....*....|....*....|...
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd14223 218 LTMAVELPDSFSPELRSLLEGLL 240
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
18-274 8.56e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 88.13  E-value: 8.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYEL---VQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPgddfsliQQEIFMVKECK-HCNIVAYFGSYLSREKLW 91
Cdd:cd14092   3 QNYELdlrEEALGDGSFSVCRKCVHKKTGQEFAVKIVsrRLDT-------SREVQLLRLCQgHPNIVKLHEVFQDELHTY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVA-AKITA 167
Cdd:cd14092  76 LVMELLRGGELLERIRKKKRFTESEASRIMRQLVSAVSFMHSKGVVHRDLKPENLLFTDEDDdaeIKIVDFGFArLKPEN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFigTPYWMAPEV-AAVEKNGGYNQLCDIWAVGITaielgelqppmfdLHPMralfLMSKSNFQPP-------- 238
Cdd:cd14092 156 QPLKTPCF--TLPYAAPEVlKQALSTQGYDESCDLWSLGVI-------------LYTM----LSGQVPFQSPsrnesaae 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 239 ---KLK------DKTKW---SSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14092 217 imkRIKsgdfsfDGEEWknvSSEAKSLIQGLLTVDPSKRLTMSELRNH 264
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
20-274 8.87e-19

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 86.87  E-value: 8.87e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14114   4 YDILEELGTGAFGVVHRCTERATGNNFAAKFIMTPHESDKETVRKEIQIMNQLHHPKLINLHDAFEDDNEMVLILEFLSG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH--GDVKLADFGVAAKITATiAKRKSFI 176
Cdd:cd14114  84 GELFErIAAEHYKMSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIMCTTKrsNEVKLIDFGLATHLDPK-ESVKVTT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKNGGYNqlcDIWAVGITA-IELGELQPpmF----DLHPMRAL----FLMSKSNFQ--PPKLKDktk 245
Cdd:cd14114 163 GTAEFAAPEIVEREPVGFYT---DMWAVGVLSyVLLSGLSP--FagenDDETLRNVkscdWNFDDSAFSgiSEEAKD--- 234
                       250       260
                ....*....|....*....|....*....
gi 38570135 246 wsstfhnFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14114 235 -------FIRKLLLADPNKRMTIHQALEH 256
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
19-276 1.15e-18

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 88.05  E-value: 1.15e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNV---HTGELAAVKIIKlepgdDFSLIQQEifmvKECKHCN--------------IVAYF 81
Cdd:cd05614   1 NFELLKVLGTGAYGKVFLVRKVsghDANKLYAMKVLR-----KAALVQKA----KTVEHTRternvlehvrqspfLVTLH 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  82 GSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd05614  72 YAFQTDAKLHLILDYVSGGELFTHLYQRDHFSEDEVRFYSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRK-SFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRalflmsksNFQPPKL 240
Cdd:cd05614 152 SKEFLTEEKERTySFCGTIEYMAPEI--IRGKSGHGKAVDWWSLGILMFELLTGASP-FTLEGEK--------NTQSEVS 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 241 KDKTKWSSTFHNFV--------KIALTKNPKKR----PT-AERLLTHTF 276
Cdd:cd05614 221 RRILKCDPPFPSFIgpvardllQKLLCKDPKKRlgagPQgAQEIKEHPF 269
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
24-272 1.16e-18

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 87.45  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELA----AVKII--KLEPGDDFSL---IQQEIFMVKECKHCNIVAYFG-SYLSREKLWIC 93
Cdd:cd14001   5 KKLGYGTGVNVYLMKRSPRGGSSrspwAVKKInsKCDKGQRSLYqerLKEEAKILKSLNHPNIVGFRAfTKSEDGSLCLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGgSLQDI-----YHVTGPLSELQIAYVCRETLQGLAYLHTKGK-MHRDIKGANILLT-DHGDVKLADFGVAAKIT 166
Cdd:cd14001  85 MEYGGK-SLNDLieeryEAGLGPFPAATILKVALSIARALEYLHNEKKiLHGDIKSGNVLIKgDFESVKLCDFGVSLPLT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIA----KRKSFIGTPYWMAPEvaAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFL---MSKSNFQP-- 237
Cdd:cd14001 164 ENLEvdsdPKAQYVGTEPWKAKE--ALEEGGVITDKADIFAYGLVLWEMMTLSVPHLNLLDIEDDDEdesFDEDEEDEea 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 238 --------PKLKDKTKWSStfHNFVkIAL-----TKNPKKRPTAERLL 272
Cdd:cd14001 242 yygtlgtrPALNLGELDDS--YQKV-IELfyactQEDPKDRPSAAHIV 286
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
16-315 1.17e-18

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 88.17  E-value: 1.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQdYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlEPGDdfSLIQ-----QEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd07877  16 PER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS-RPFQ--SIIHakrtyRELRLLKHMKHENVIGLLDVFTPARSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 wicmeycggGSLQDIYHVT-------------GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLA 157
Cdd:cd07877  92 ---------EEFNDVYLVThlmgadlnnivkcQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 158 DFGVAAKitaTIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL--GELQPPMFDlHPMRALFLMSKSNF 235
Cdd:cd07877 163 DFGLARH---TDDEMTGYVATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAELltGRTLFPGTD-HIDQLKLILRLVGT 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 236 QPPKLKDKTKwSSTFHNFVKiALTKNPKKRptaerlLTHTFV-AQPglsraLAVELLDKVNNPDN-----------HAHY 303
Cdd:cd07877 237 PGAELLKKIS-SESARNYIQ-SLTQMPKMN------FANVFIgANP-----LAVDLLEKMLVLDSdkritaaqalaHAYF 303
                       330
                ....*....|..
gi 38570135 304 TEADDDDFEPHA 315
Cdd:cd07877 304 AQYHDPDDEPVA 315
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
21-211 1.21e-18

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 87.26  E-value: 1.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDV----YKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFG--SYLSREKLWIC 93
Cdd:cd05080   7 KKIRDLGEGHFGKVslycYDPTNDGTGEMVAVKALKADCGPQHrSGWKQEIDILKTLYHENIVKYKGccSEQGGKSLQLI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDiYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-TATIAKR 172
Cdd:cd05080  87 MEYVPLGSLRD-YLPKHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVpEGHEYYR 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 38570135 173 KSFIG-TP-YWMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05080 166 VREDGdSPvFWYAPECL---KEYKFYYASDVWSFGVTLYEL 203
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
18-221 1.29e-18

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 88.55  E-value: 1.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLWIC 93
Cdd:cd05618  20 QDFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKElvnDDEDIDWVQTEKHVFEQASnHPFLVGLHSCFQTESRLFFV 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd05618 100 IEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTS 179
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 174 SFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDL 221
Cdd:cd05618 180 TFCGTPNYIAPEILRGED---YGFSVDWWALGVLMFEMMAGRSP-FDI 223
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
20-220 1.32e-18

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 86.60  E-value: 1.32e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14191   4 YDIEERLGSGKFGQVFRLVEKKTKKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEMVSG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH--GDVKLADFGVAAKITATiAKRKSFI 176
Cdd:cd14191  84 GELFErIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKtgTKIKLIDFGLARRLENA-GSLKVLF 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 177 GTPYWMAPEVAAVEKNGgynQLCDIWAVG-ITAIELGELQPPMFD 220
Cdd:cd14191 163 GTPEFVAPEVINYEPIG---YATDMWSIGvICYILVSGLSPFMGD 204
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
18-216 1.86e-18

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 86.63  E-value: 1.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTG----ELAAVKIIKLEPGDDFSLIQQEIFM--VKECKHCNIVAYFG----SYLSR 87
Cdd:cd07862   1 QQYECVAEIGEGAYGKVFKARDLKNGgrfvALKRVRVQTGEEGMPLSTIREVAVLrhLETFEHPNVVRLFDvctvSRTDR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 E-KLWICMEYCGGGSLQDIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKI 165
Cdd:cd07862  81 EtKLTLVFEHVDQDLTTYLDKVPEPgVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGL-ARI 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 38570135 166 TATIAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07862 160 YSFQMALTSVVVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKP 207
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
18-206 2.35e-18

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 87.02  E-value: 2.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQR---VGSGTYGDVYKARNVHTGELAAVKII--KLEpgddfSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLW 91
Cdd:cd14179   4 QHYELDLKdkpLGEGSFSICRKCLHKKTNQEYAVKIVskRME-----ANTQREIAALKLCEgHPNIVKLHEVYHDQLHTF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITAT 168
Cdd:cd14179  79 LVMELLKGGELLERIKKKQHFSETEASHIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDESDnseIKIIDFGFARLKPPD 158
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 38570135 169 IAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd14179 159 NQPLKTPCFTLHYAAPELL---NYNGYDESCDLWSLGV 193
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
20-211 2.46e-18

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 87.27  E-value: 2.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKiiKL-EPgddfslIQQEIF---------MVKECKHCNIVAYFGSYLSR-- 87
Cdd:cd07879  17 YTSLKQVGSGAYGSVCSAIDKRTGEKVAIK--KLsRP------FQSEIFakrayreltLLKHMQHENVIGLLDVFTSAvs 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 ----EKLWICMEYCgggsLQDIYHVTG-PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd07879  89 gdefQDFYLVMPYM----QTDLQKIMGhPLSEDKVQYLVYQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLA 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 163 AKITATIAkrkSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd07879 165 RHADAEMT---GYVVTRWYRAPEV--ILNWMHYNQTVDIWSVGCIMAEM 208
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
4-233 2.75e-18

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 86.32  E-value: 2.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   4 PLRPAADIlrrnPQQDYELVQRVGSGTYGDVYKAR-----NVHTGELA-AVKIIKLEPGD-DFSLIQQEIFMVKEC-KHC 75
Cdd:cd05053   2 PLDPEWEL----PRDRLTLGKPLGEGAFGQVVKAEavgldNKPNEVVTvAVKMLKDDATEkDLSDLVSEMEMMKMIgKHK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  76 NIVAYFGSYLSREKLWICMEYCGGGSLQDIYH----------------VTGPLSELQIAYVCRETLQGLAYLHTKGKMHR 139
Cdd:cd05053  78 NIINLLGACTQDGPLYVVVEYASKGNLREFLRarrppgeeaspddprvPEEQLTQKDLVSFAYQVARGMEYLASKKCIHR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 140 DIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG-TPY-WMAPEvaAVEKNgGYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd05053 158 DLAARNVLVTEDNVMKIADFGLARDIHHIDYYRKTTNGrLPVkWMAPE--ALFDR-VYTHQSDVWSFGVLLWEIFTLGGS 234
                       250
                ....*....|....*.
gi 38570135 218 MFDLHPMRALFLMSKS 233
Cdd:cd05053 235 PYPGIPVEELFKLLKE 250
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
26-214 2.86e-18

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 85.42  E-value: 2.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKArnVHTGELAAVKIIKLEPGDDFSL----IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd14148   2 IGVGGFGKVYKG--LWRGEEVAVKAARQDPDEDIAVtaenVRQEARLFWMLQHPNIIALRGVCLNPPHLCLVMEYARGGA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIY-------HVTGPLSeLQIAyvcretlQGLAYLHTKGK---MHRDIKGANILLTDHGD--------VKLADFGVAA 163
Cdd:cd14148  80 LNRALagkkvppHVLVNWA-VQIA-------RGMNYLHNEAIvpiIHRDLKSSNILILEPIEnddlsgktLKITDFGLAR 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 164 KITATiaKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL--GEL 214
Cdd:cd14148 152 EWHKT--TKMSAAGTYAWMAPEVI---RLSLFSKSSDVWSFGVLLWELltGEV 199
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
26-206 2.92e-18

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 85.45  E-value: 2.92e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEpgddfsLIQQEIFmVKE-------CKHCNIVAYFGSYLSREKLWI-CMEYC 97
Cdd:cd13987   1 LGEGTYGKVLLAVHKGSGTKMALKFVPKP------STKLKDF-LREynislelSVHPHIIKTYDVAFETEDYYVfAQEYA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG--DVKLADFGVAAKITATIaKRKSF 175
Cdd:cd13987  74 PYGDLFSIIPPQVGLPEERVKRCAAQLASALDFMHSKNLVHRDIKPENVLLFDKDcrRVKLCDFGLTRRVGSTV-KRVSG 152
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 176 IgTPYwMAPEVAAVEKNGGY--NQLCDIWAVGI 206
Cdd:cd13987 153 T-IPY-TAPEVCEAKKNEGFvvDPSIDVWAFGV 183
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
19-272 2.95e-18

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 85.86  E-value: 2.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARnVHtGElAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14063   1 ELEIKEVIGKGRFGRVHRGR-WH-GD-VAIKLLNIDYLNEEQLeaFKEEVAAYKNTRHDNLVLFMGACMDPPHLAIVTSL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLtDHGDVKLADFGV--AAKITATIAKRK 173
Cdd:cd14063  78 CKGRTLYSlIHERKEKFDFNKTVQIAQQICQGMGYLHAKGIIHKDLKSKNIFL-ENGRVVITDFGLfsLSGLLQPGRRED 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYW---MAPEVA-------AVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDK 243
Cdd:cd14063 157 TLVIPNGWlcyLAPEIIralspdlDFEESLPFTKASDVYAFGTVWYELLAGRWPFKEQPAESIIWQVGCGKKQSLSQLDI 236
                       250       260
                ....*....|....*....|....*....
gi 38570135 244 TKwssTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd14063 237 GR---EVKDILMQCWAYDPEKRPTFSDLL 262
STKc_Sid2p_like cd05600
Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the ...
19-205 3.13e-18

Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group contains fungal kinases including Schizosaccharomyces pombe Sid2p and Saccharomyces cerevisiae Dbf2p. Group members show similarity to NDR kinases in that they contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Sid2p plays a crucial role in the septum initiation network (SIN) and in the initiation of cytokinesis. Dbf2p is important in regulating the mitotic exit network (MEN) and in cytokinesis. The Sid2p-like group is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270751 [Multi-domain]  Cd Length: 386  Bit Score: 87.78  E-value: 3.13e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK---LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05600  12 DFQILTQVGQGGYGSVFLARKKDTGEICALKIMKkkvLFKLNEVNHVLTERDILTTTNSPWLVKLLYAFQDPENVYLAME 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA-------- 167
Cdd:cd05600  92 YVPGGDFRTLLNNSGILSEEHARFYIAEMFAAISSLHQLGYIHRDLKPENFLIDSSGHIKLTDFGLASGTLSpkkiesmk 171
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 168 --------------TIAKR---------------KSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVG 205
Cdd:cd05600 172 irleevkntaflelTAKERrniyramrkedqnyaNSVVGSPDYMAPEVLRGE---GYDLTVDYWSLG 235
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
26-298 3.29e-18

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 85.85  E-value: 3.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCNIVAYfgSYLSREKLWICMEYCGGG 100
Cdd:cd05630   8 LGKGGFGEVCACQVRATGKMYACKKlekkrIKKRKGEAMALNEKQILEKVNSRFVVSLAY--AYETKDALCLVLTLMNGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHV-TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT--ATIAKRksfI 176
Cdd:cd05630  86 DLKfHIYHMgQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPegQTIKGR---V 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmfdlhpmralFLMSKSNFQPPKLKDKTK-----WSSTF- 250
Cdd:cd05630 163 GTVGYMAPEVV---KNERYTFSPDWWALGCLLYEMIAGQSP----------FQQRKKKIKREEVERLVKevpeeYSEKFs 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 251 ---HNFVKIALTKNPKKR-----PTAERLLTHTFVAQPGLSRaLAVELLDKVNNPD 298
Cdd:cd05630 230 pqaRSLCSMLLCKDPAERlgcrgGGAREVKEHPLFKKLNFKR-LGAGMLEPPFKPD 284
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
20-315 3.33e-18

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 86.93  E-value: 3.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGelAAVKIIKLepgddFSLIQQEIF---------MVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd07880  17 YRDLKQVGSGAYGTVCSALDRRTG--AKVAIKKL-----YRPFQSELFakrayrelrLLKHMKHENVIGLLDVFTPDLSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 ------WICMEYCGGGSLQDIYHVTgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd07880  90 drfhdfYLVMPFMGTDLGKLMKHEK--LSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 itaTIAKRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELgELQPPMFDLHP-MRALFLMSKSNFQPPKLKDK 243
Cdd:cd07880 168 ---TDSEMTGYVVTRWYRAPEV--ILNWMHYTQTVDIWSVGCIMAEM-LTGKPLFKGHDhLDQLMEIMKVTGTPSKEFVQ 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 244 TKWSSTFHNFVKiALTKNPKK---------RPTAERLLTHTFVAQPGlSRALAVELLdkvnnpdNHAHYTEADDDDFEPH 314
Cdd:cd07880 242 KLQSEDAKNYVK-KLPRFRKKdfrsllpnaNPLAVNVLEKMLVLDAE-SRITAAEAL-------AHPYFEEFHDPEDETE 312

                .
gi 38570135 315 A 315
Cdd:cd07880 313 A 313
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
20-276 3.43e-18

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 85.01  E-value: 3.43e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14079   4 YILGKTLGVGSFGKVKLAEHELTGHKVAVKILnrqKIKSLDMEEKIRREIQILKLFRHPHIIRLYEVIETPTDIFMVMEY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaakitATIAKRKSFI 176
Cdd:cd14079  84 VSGGELFDYIVQKGRLSEDEARRFFQQIISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGL-----SNIMRDGEFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 ----GTPYWMAPEVAAVEKNGGYNqlCDIWAVGIT--AIELGELqPpmFDLHPMRALFLMSKS-NFQPPklkdkTKWSST 249
Cdd:cd14079 159 ktscGSPNYAAPEVISGKLYAGPE--VDVWSCGVIlyALLCGSL-P--FDDEHIPNLFKKIKSgIYTIP-----SHLSPG 228
                       250       260
                ....*....|....*....|....*..
gi 38570135 250 FHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14079 229 ARDLIKRMLVVDPLKRITIPEIRQHPW 255
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
27-210 3.47e-18

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 85.96  E-value: 3.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQ---EIFMVKECKHCNIVAYFG-----SYLSREKL-WICMEYC 97
Cdd:cd13989   2 GSGGFGYVTLWKHQDTGEYVAIKKCRQELSPSDKNRERwclEVQIMKKLNHPNVVSARDvppelEKLSPNDLpLLAMEYC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYH----VTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITATiA 170
Cdd:cd13989  82 SGGDLRKVLNqpenCCG-LKESEVRTLLSDISSAISYLHENRIIHRDLKPENIVLQQGGGrviYKLIDLGYAKELDQG-S 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:cd13989 160 LCTSFVGTLQYLAPELFESKK---YTCTVDYWSFGTLAFE 196
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
25-186 3.55e-18

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 85.79  E-value: 3.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFSLiQQEIFMVKECKHCNIVAYFG----SYLSREKLWICMEYCGGG 100
Cdd:cd14056   2 TIGKGRYGEVWLGK--YRGEKVAVKIFSSRDEDSWFR-ETEIYQTVMLRHENILGFIAadikSTGSWTQLWLITEYHEHG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDiYHVTGPLSELQIAYVCRETLQGLAYLHT-----KGK---MHRDIKGANILLTDHGDVKLADFGVA----AKITAT 168
Cdd:cd14056  79 SLYD-YLQRNTLDTEEALRLAYSAASGLAHLHTeivgtQGKpaiAHRDLKSKNILVKRDGTCCIADLGLAvrydSDTNTI 157
                       170
                ....*....|....*...
gi 38570135 169 IAKRKSFIGTPYWMAPEV 186
Cdd:cd14056 158 DIPPNPRVGTKRYMAPEV 175
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
26-278 3.72e-18

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 86.47  E-value: 3.72e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKlepgddfsliQQEIFMVKECKHC----------------NIVAYFGSYLSREK 89
Cdd:cd05586   1 IGKGTFGQVYQVRKKDTRRIYAMKVLS----------KKVIVAKKEVAHTigernilvrtaldespFIVGLKFSFQTPTD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLqdIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05586  71 LYLVTDYMSGGEL--FWHLQkeGRFSEDRAKFYIAELVLALEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKADLT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEVAAVEKngGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFQPPKLKDKTK 245
Cdd:cd05586 149 DNKTTNTFCGTTEYLAPEVLLDEK--GYTKMVDFWSLGVLVFEMCCGWSPFYaeDTQQMYRNIAFGKVRFPKDVLSDEGR 226
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 246 wsstfhNFVKIALTKNPKKR----PTAERLLTHTFVA 278
Cdd:cd05586 227 ------SFVKGLLNRNPKHRlgahDDAVELKEHPFFA 257
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
22-211 3.94e-18

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 85.48  E-value: 3.94e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKArnVHTGELAAVKIIKLEPGDDFSL----IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14145  10 LEEIIGIGGFGKVYRA--IWIGDEVAVKAARHDPDEDISQtienVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCrETLQGLAYLHTKG---KMHRDIKGANILL---TDHGD-----VKLADFGVAAKIT 166
Cdd:cd14145  88 RGGPLNRVLSGKRIPPDILVNWAV-QIARGMNYLHCEAivpVIHRDLKSSNILIlekVENGDlsnkiLKITDFGLAREWH 166
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 167 ATiaKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14145 167 RT--TKMSAAGTYAWMAPEVI---RSSMFSKGSDVWSYGVLLWEL 206
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
25-211 3.99e-18

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 84.64  E-value: 3.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKAR-NVHTGelAAVKIIKlePG----DDFSliqQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05034   2 KLGAGQFGEVWMGVwNGTTK--VAVKTLK--PGtmspEAFL---QEAQIMKKLRHDKLVQLYAVCSDEEPIYIVTELMSK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDiYHVTGPLSEL----------QIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Cdd:cd05034  75 GSLLD-YLRTGEGRALrlpqlidmaaQIA-------SGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLIEDDE 146
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 170 AKRKSFIGTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05034 147 YTAREGAKFPIkWTAPEAA---LYGRFTIKSDVWSFGILLYEI 186
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
25-203 4.12e-18

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 85.26  E-value: 4.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEpgddfsliqqeIFMVKECKHCN------IVAYFGSYlsREKLW--ICMEY 96
Cdd:cd13991  13 RIGRGSFGEVHRMEDKQTGFQCAVKKVRLE-----------VFRAEELMACAgltsprVVPLYGAV--REGPWvnIFMDL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG-DVKLADFGVAAKI-----TATIA 170
Cdd:cd13991  80 KEGGSLGQLIKEQGCLPEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSDGsDAFLCDFGHAECLdpdglGKSLF 159
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 171 KRKSFIGTPYWMAPEVAAVEKNGGYnqlCDIWA 203
Cdd:cd13991 160 TGDYIPGTETHMAPEVVLGKPCDAK---VDVWS 189
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
26-261 4.26e-18

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 86.65  E-value: 4.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCN-IVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05633  13 IGRGGFGEVYGCRKADTGKMYAMKCldkkrIKMKQGETLALNERIMLSLVSTGDCPfIVCMTYAFHTPDKLCFILDLMNG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQdiYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKSFIG 177
Cdd:cd05633  93 GDLH--YHLSqhGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELgelqppmfdlhpmralfLMSKSNFQPPKLKDKtkwsstfHNFVKIA 257
Cdd:cd05633 169 THGYMAPEV--LQKGTAYDSSADWFSLGCMLFKL-----------------LRGHSPFRQHKTKDK-------HEIDRMT 222

                ....
gi 38570135 258 LTKN 261
Cdd:cd05633 223 LTVN 226
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
19-279 5.38e-18

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 85.47  E-value: 5.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRV-GSGTYGDVYKARNVHTGELAAVKIIKlepgdDFSLIQQEI---FMVKECKH-CNIV-AYFGSYLSREKLWI 92
Cdd:cd14170   2 DYKVTSQVlGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVelhWRASQCPHiVRIVdVYENLYAGRKCLLI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQDIYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD---HGDVKLADFGVaAKITA 167
Cdd:cd14170  77 VMECLDGGELFSRIQDRGdqAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSkrpNAILKLTDFGF-AKETT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLH------PMRALFLMSKSNFQPPKLk 241
Cdd:cd14170 156 SHNSLTTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHglaispGMKTRIRMGQYEFPNPEW- 231
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 38570135 242 dkTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14170 232 --SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 267
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
20-278 5.77e-18

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 85.92  E-value: 5.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpgddfSLIQQEIFM---VKECK-------HCNIV----------- 78
Cdd:cd07857   2 YELIKELGQGAYGIVCSARNAETSEEETVAIKKIT-----NVFSKKILAkraLRELKllrhfrgHKNITclydmdivfpg 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  79 AYFGSYLSREklwiCMEYcgggSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLAD 158
Cdd:cd07857  77 NFNELYLYEE----LMEA----DLHQIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICD 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 159 FGVAAKITATIAKRKSFI----GTPYWMAPEVaaVEKNGGYNQLCDIWAVG-ITAIELGelQPPMFD----LHPM----- 224
Cdd:cd07857 149 FGLARGFSENPGENAGFMteyvATRWYRAPEI--MLSFQSYTKAIDVWSVGcILAELLG--RKPVFKgkdyVDQLnqilq 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 225 ----------------RALFLMSKSNFQPPKlkdKTKWSSTFHNFVKIALTK-----NPKKRPTAERLLTHTFVA 278
Cdd:cd07857 225 vlgtpdeetlsrigspKAQNYIRSLPNIPKK---PFESIFPNANPLALDLLEkllafDPTKRISVEEALEHPYLA 296
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
26-220 6.55e-18

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 84.59  E-value: 6.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL-QD 104
Cdd:cd14190  12 LGGGKFGKVHTCTEKRTGLKLAAKVINKQNSKDKEMVLLEIQVMNQLNHRNLIQLYEAIETPNEIVLFMEYVEGGELfER 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL---TDHgDVKLADFGVAAKITATiAKRKSFIGTPYW 181
Cdd:cd14190  92 IVDEDYHLTEVDAMVFVRQICEGIQFMHQMRVLHLDLKPENILCvnrTGH-QVKIIDFGLARRYNPR-EKLKVNFGTPEF 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 182 MAPEVAavekngGYNQL---CDIWAVG-ITAIELGELQPPMFD 220
Cdd:cd14190 170 LSPEVV------NYDQVsfpTDMWSMGvITYMLLSGLSPFLGD 206
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
18-224 6.56e-18

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 85.15  E-value: 6.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIiklepgddfsLIQQEIFMVKECKHC-------------NIVAYFGSY 84
Cdd:cd14209   1 DDFDRIKTLGTGSFGRVMLVRHKETGNYYAMKI----------LDKQKVVKLKQVEHTlnekrilqainfpFLVKLEYSF 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd14209  71 KDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKR 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 165 I---TATIAkrksfiGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPM 224
Cdd:cd14209 151 VkgrTWTLC------GTPEYLAPEII---LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 204
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
20-278 7.44e-18

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 85.70  E-value: 7.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIkLEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGSYLSreklwicmey 96
Cdd:cd07856  12 YSDLQPVGMGAFGLVCSARDQLTGQNVAVKKI-MKPFSTPVLAKrtyRELKLLKHLRHENIISLSDIFIS---------- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 cgggSLQDIYHVT-------------GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaA 163
Cdd:cd07856  81 ----PLEDIYFVTellgtdlhrlltsRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGL-A 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITAtiAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP---------------PMFDLHPMRALF 228
Cdd:cd07856 156 RIQD--PQMTGYVSTRYYRAPEIMLTWQK--YDVEVDIWSAGCIFAEMLEGKPlfpgkdhvnqfsiitELLGTPPDDVIN 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135 229 LMSKSN----FQPPKLKDKTKWSSTFHN-------FVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd07856 232 TICSENtlrfVQSLPKRERVPFSEKFKNadpdaidLLEKMLVFDPKKRISAAEALAHPYLA 292
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
26-279 8.69e-18

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 84.36  E-value: 8.69e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTG------ELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM----E 95
Cdd:cd14032   9 LGRGSFKTVYKGLDTETWvevawcELQDRKLTKVER----QRFKEEAEMLKGLQHPNIVRFYDFWESCAKGKRCIvlvtE 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTD-HGDVKLADFGVAAKITATIAKr 172
Cdd:cd14032  85 LMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPpiIHRDLKCDNIFITGpTGSVKIGDLGLATLKRASFAK- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 kSFIGTPYWMAPEVaaVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTkwSSTFHN 252
Cdd:cd14032 164 -SVIGTPEFMAPEM--YEEH--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVT--DPEIKE 236
                       250       260
                ....*....|....*....|....*..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14032 237 IIGECICKNKEERYEIKDLLSHAFFAE 263
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
17-274 1.03e-17

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 84.22  E-value: 1.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELV--QRVGSGTYGDVYKARNVHTG-ELAAVKIIKLEPGDDFSL-IQQEIfMVKECKHCN--IVAYFGSYLSREKL 90
Cdd:cd14197   6 QERYSLSpgRELGRGKFAVVRKCVEKDSGkEFAAKFMRKRRKGQDCRMeIIHEI-AVLELAQANpwVINLHEVYETASEM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSL--QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH---GDVKLADFGVaAKI 165
Cdd:cd14197  85 ILVLEYAAGGEIfnQCVADREEAFKEKDVKRLMKQILEGVSFLHNNNVVHLDLKPQNILLTSEsplGDIKIVDFGL-SRI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 TATIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITA-IELGELQPPMFDlhPMRALFL-MSKSNFQPPKlKDK 243
Cdd:cd14197 164 LKNSEELREIMGTPEYVAPEILSYEP---ISTATDMWSIGVLAyVMLTGISPFLGD--DKQETFLnISQMNVSYSE-EEF 237
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 244 TKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14197 238 EHLSESAIDFIKTLLIKKPENRATAEDCLKH 268
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
20-277 1.09e-17

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 84.90  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIFMVKECKH---------CNIVAYFGSYLSREKL 90
Cdd:cd14210  15 YEVLSVLGKGSFGQVVKCLDHKTGQLVAIKIIR----NKKRFHQQALVEVKILKHlndndpddkHNIVRYKDSFIFRGHL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGggslQDIYHVTG-----PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD--HGDVKLADFGVAA 163
Cdd:cd14210  91 CIVFELLS----INLYELLKsnnfqGLSLSLIRKFAKQILQALQFLHKLNIIHCDLKPENILLKQpsKSSIKVIDFGSSC 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAkrkSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL--GElqpPMF------DL---------HPMRA 226
Cdd:cd14210 167 FEGEKVY---TYIQSRFYRAPEVIL---GLPYDTAIDMWSLGCILAELytGY---PLFpgeneeEQlacimevlgVPPKS 237
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38570135 227 LFLMSK-------SNFQPPKLKD---KTKWSST-------------FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14210 238 LIDKASrrkkffdSNGKPRPTTNskgKKRRPGSkslaqvlkcddpsFLDFLKKCLRWDPSERMTPEEALQHPWI 311
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
25-265 1.24e-17

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 84.33  E-value: 1.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RV-GSGTYGDVYKARNVHTGELAAVKiiKLEP-------GDDFSLIQQEI-------FMVKeckhcniVAYfgSYLSREK 89
Cdd:cd05605   6 RVlGKGGFGEVCACQVRATGKMYACK--KLEKkrikkrkGEAMALNEKQIlekvnsrFVVS-------LAY--AYETKDA 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQ-DIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA 167
Cdd:cd05605  75 LCLVLTIMNGGDLKfHIYNMGNPgFEEERAVFYAAEITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 --TIAKRksfIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRalflMSKSNFQPPKLKDKTK 245
Cdd:cd05605 155 geTIRGR---VGTVGYMAPEVV---KNERYTFSPDWWGLGCLIYEMIEGQAP-FRARKEK----VKREEVDRRVKEDQEE 223
                       250       260
                ....*....|....*....|....
gi 38570135 246 WSSTF----HNFVKIALTKNPKKR 265
Cdd:cd05605 224 YSEKFseeaKSICSQLLQKDPKTR 247
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
26-279 1.35e-17

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 84.16  E-value: 1.35e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII-----KLEPGDDFSLIQQEIFMVKECKHCNIVAYfgSYLSREKLWICMEYCGGG 100
Cdd:cd05608   9 LGKGGFGEVSACQMRATGKLYACKKLnkkrlKKRKGYEGAMVEKRILAKVHSRFIVSLAY--AFQTKTDLCLVMTIMNGG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHV--TGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd05608  87 DLRyHIYNVdeENPgFQEPRACFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAVELKDGQTKTKGYA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmfdlhpmralFLMSKSNFQPPKLKDKT---------KWS 247
Cdd:cd05608 167 GTPGFMAPELLLGEE---YDYSVDYFTLGVTLYEMIAARGP----------FRARGEKVENKELKQRIlndsvtyseKFS 233
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 248 STFHNFVKIALTKNPKKR-----PTAERLLTHTFVAQ 279
Cdd:cd05608 234 PASKSICEALLAKDPEKRlgfrdGNCDGLRTHPFFRD 270
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
18-221 1.47e-17

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 85.07  E-value: 1.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLWIC 93
Cdd:cd05617  15 QDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKElvhDDEDIDWVQTEKHVFEQASsNPFLVGLHSCFQTTSRLFLV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRK 173
Cdd:cd05617  95 IEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTS 174
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 174 SFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDL 221
Cdd:cd05617 175 TFCGTPNYIAPEILRGEE---YGFSVDWWALGVLMFEMMAGRSP-FDI 218
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
18-272 1.51e-17

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 83.43  E-value: 1.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14110   3 KTYAFQTEINRGRFSVVRQCEEKRSGQMLAAKIIPYKP-EDKQLVLREYQVLRRLSHPRIAQLHSAYLSPRHLVLIEELC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT---ATIAKRKS 174
Cdd:cd14110  82 SGPELLYNLAERNSYSEAEVTDYLWQILSAVDYLHSRRILHLDLRSENMIITEKNLLKIVDLGNAQPFNqgkVLMTDKKG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPywMAPEVaaVEKNGGYNQlCDIWAVGITA-IELGELQPPMFDLhpmralflmsKSNFQPPKLKDKTKWSSTFH-- 251
Cdd:cd14110 162 DYVET--MAPEL--LEGQGAGPQ-TDIWAIGVTAfIMLSADYPVSSDL----------NWERDRNIRKGKVQLSRCYAgl 226
                       250       260
                ....*....|....*....|....*.
gi 38570135 252 -----NFVKIALTKNPKKRPTAERLL 272
Cdd:cd14110 227 sggavNFLKSTLCAKPWGRPTASECL 252
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
22-238 1.57e-17

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 83.97  E-value: 1.57e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKAR----NVHTGELAAVKIIKLEPGD----DFsliQQEIFMVKECKHCNIVAYFG-SY-LSREKLW 91
Cdd:cd05038   8 FIKQLGEGHFGSVELCRydplGDNTGEQVAVKSLQPSGEEqhmsDF---KREIEILRTLDHEYIVKYKGvCEsPGRRSLR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQD--------IYHVTGPLSELQIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd05038  85 LIMEYLPSGSLRDylqrhrdqIDLKRLLLFASQIC-------KGMEYLGSQRYIHRDLAARNILVESEDLVKISDFGLAK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITA------TIAKRKSFIgtpYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmfDLHPMrALFLMSKSNFQP 237
Cdd:cd05038 158 VLPEdkeyyyVKEPGESPI---FWYAPECLRESR---FSSASDVWSFGVTLYELFTYGDP--SQSPP-ALFLRMIGIAQG 228

                .
gi 38570135 238 P 238
Cdd:cd05038 229 Q 229
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
26-214 1.58e-17

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 83.55  E-value: 1.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKArnVHTGELAAVKIIKLEPGDDFSL----IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd14146   2 IGVGGFGKVYRA--TWKGQEVAVKAARQDPDEDIKAtaesVRQEAKLFSMLRHPNIIKLEGVCLEEPNLCLVMEFARGGT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQ----DIYHVTGPLSELQI-----AYVCRETLQGLAYLHTKGK---MHRDIKGANILL---TDHGDV-----KLADFGV 161
Cdd:cd14146  80 LNralaAANAAPGPRRARRIpphilVNWAVQIARGMLYLHEEAVvpiLHRDLKSSNILLlekIEHDDIcnktlKITDFGL 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 162 AAKITATiaKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL--GEL 214
Cdd:cd14146 160 AREWHRT--TKMSAAGTYAWMAPEVI---KSSLFSKGSDIWSYGVLLWELltGEV 209
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
26-277 1.67e-17

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 83.93  E-value: 1.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK-HCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14174  10 LGEGAYAKVQGCVSLQNGKEYAVKIIEKNAGHSRSRVFREVETLYQCQgNKNILELIEFFEDDTRFYLVFEKLRGGSILA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL--LTDH-GDVKLADFGVAAKI-------TATIAKRKS 174
Cdd:cd14174  90 HIQKRKHFNEREASRVVRDIASALDFLHTKGIAHRDLKPENILceSPDKvSPVKICDFDLGSGVklnsactPITTPELTT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAV--EKNGGYNQLCDIWAVGITAIELGELQPPMF-----DLHPMRA---------LF-LMSKSNFQP 237
Cdd:cd14174 170 PCGSAEYMAPEVVEVftDEATFYDKRCDLWSLGVILYIMLSGYPPFVghcgtDCGWDRGevcrvcqnkLFeSIQEGKYEF 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 238 PKlKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14174 250 PD-KDWSHISSEAKDLISKLLVRDAKERLSAAQVLQHPWV 288
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
26-217 1.87e-17

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 84.23  E-value: 1.87e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIfmvkEC----KHCNIVAYFGSYLS--------REKLWIC 93
Cdd:cd05620   3 LGKGSFGKVLLAELKGKGEYFAVKALK----KDVVLIDDDV----ECtmveKRVLALAWENPFLThlyctfqtKEHLFFV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLqdIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd05620  75 MEFLNGGDL--MFHIqdKGRFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENVFGDNR 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 172 RKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPP 217
Cdd:cd05620 153 ASTFCGTPDYIAPEILQGLK---YTFSVDWWSFGVLLYEMLIGQSP 195
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
20-211 1.89e-17

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 84.65  E-value: 1.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKiiKL-EPGddFSLIQ-----QEIFMVKECKHCNIVAYFGSYLSREKLwic 93
Cdd:cd07851  17 YQNLSPVGSGAYGQVCSAFDTKTGRKVAIK--KLsRPF--QSAIHakrtyRELRLLKHMKHENVIGLLDVFTPASSL--- 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 meycggGSLQDIYHVT-------------GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG 160
Cdd:cd07851  90 ------EDFQDVYLVThlmgadlnnivkcQKLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFG 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 38570135 161 VAAKitaTIAKRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd07851 164 LARH---TDDEMTGYVATRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAEL 209
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
19-276 2.03e-17

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 83.51  E-value: 2.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVH---TGELAAVKIIKlepgdDFSLIQQeifmVKECKHCN--------------IVAYF 81
Cdd:cd05613   1 NFELLKVLGTGAYGKVFLVRKVSghdAGKLYAMKVLK-----KATIVQK----AKTAEHTRterqvlehirqspfLVTLH 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  82 GSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV 161
Cdd:cd05613  72 YAFQTDTKLHLILDYINGGELFTHLSQRERFTENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAKRK-SFIGTPYWMAPEVAAvEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS--NFQPP 238
Cdd:cd05613 152 SKEFLLDENERAySFCGTIEYMAPEIVR-GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRilKSEPP 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 239 KLKDktkWSSTFHNFVKIALTKNPKKR----PT-AERLLTHTF 276
Cdd:cd05613 231 YPQE---MSALAKDIIQRLLMKDPKKRlgcgPNgADEIKKHPF 270
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
20-216 2.52e-17

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 83.12  E-value: 2.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKiiKLEPGDDFSLIQQ----EIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd07848   3 FEVLGVVGEGAYGVVLKCRHKETKEIVAIK--KFKDSEENEEVKEttlrELKMLRTLKQENIVELKEAFRRRGKLYLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIY-HVTGPLSELQIAYVcRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT-ATIAKRK 173
Cdd:cd07848  81 YVEKNMLELLEeMPNGVPPEKVRSYI-YQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSeGSNANYT 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 174 SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07848 160 EYVATRWYRSPELLL---GAPYGKAVDMWSVGCILGELSDGQP 199
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
20-266 2.58e-17

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 82.56  E-value: 2.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14070   4 YLIGRKLGEGSFAKVREGLHAVTGEKVAIKVIdkKKAKKDSYVTknLRREGRIQQMIRHPNITQLLDILETENSYYLVME 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA--AKITATIAKRK 173
Cdd:cd14070  84 LCPGGNLMHRIYDKKRLEEREARRYIRQLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLSncAGILGYSDPFS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGIT--AIELGELqPPMFDLHPMRALF---LMSKSNFQPPKLkdktkwSS 248
Cdd:cd14070 164 TQCGSPAYAAPELLARKK---YGPKVDVWSIGVNmyAMLTGTL-PFTVEPFSLRALHqkmVDKEMNPLPTDL------SP 233
                       250
                ....*....|....*...
gi 38570135 249 TFHNFVKIALTKNPKKRP 266
Cdd:cd14070 234 GAISFLRSLLEPDPLKRP 251
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
20-213 2.61e-17

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 83.89  E-value: 2.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlePGD-------DFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKLW 91
Cdd:cd05589   1 FRCIAVLGRGHFGKVLLAEYKPTGELFAIKALK--KGDiiardevESLMCEKRIFETVNSaRHPFLVNLFACFQTPEHVC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSL-----QDIYhvtgplSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd05589  79 FVMEYAAGGDLmmhihEDVF------SEPRAVFYAACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGM 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 167 ATIAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL--GE 213
Cdd:cd05589 153 GFGDRTSTFCGTPEFLAPEVLT---DTSYTRAVDWWGLGVLIYEMlvGE 198
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
20-206 3.03e-17

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 83.14  E-value: 3.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLiqqeifMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14178   5 YEIKEDIGIGSYSVCKRCVHKATSTEYAVKIIdksKRDPSEEIEI------LLRYGQHPNIITLKDVYDDGKFVYLVMEL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH-GD---VKLADFGVAAKITATIAKR 172
Cdd:cd14178  79 MRGGELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYMDEsGNpesIRICDFGFAKQLRAENGLL 158
                       170       180       190
                ....*....|....*....|....*....|....
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd14178 159 MTPCYTANFVAPEVL---KRQGYDAACDIWSLGI 189
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
22-211 3.44e-17

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 82.76  E-value: 3.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKAR----NVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLS--REKLWICME 95
Cdd:cd14205   8 FLQQLGKGNFGSVEMCRydplQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSagRRNLRLIME 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvaakITATIAKRKS 174
Cdd:cd14205  88 YLPYGSLRDyLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFG----LTKVLPQDKE 163
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 38570135 175 F--IGTP-----YWMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd14205 164 YykVKEPgespiFWYAPESLTESK---FSVASDVWSFGVVLYEL 204
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
20-277 3.56e-17

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 83.92  E-value: 3.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQqeiFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14176  21 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE---ILLRYGQHPNIITLKDVYDDGKYVYVVTELMKG 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG----DVKLADFGVAAKITATIAKRKSF 175
Cdd:cd14176  98 GELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESgnpeSIRICDFGFAKQLRAENGLLMTP 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMF---DLHPMRALFLMSKSNFQppklKDKTKWSSTFH- 251
Cdd:cd14176 178 CYTANFVAPEVL---ERQGYDAACDIWSLGVLLYTMLTGYTPFAngpDDTPEEILARIGSGKFS----LSGGYWNSVSDt 250
                       250       260
                ....*....|....*....|....*...
gi 38570135 252 --NFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14176 251 akDLVSKMLHVDPHQRLTAALVLRHPWI 278
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
26-207 4.30e-17

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 83.31  E-value: 4.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDdfslIQQEIFMV-KECKHCNIVAYFGS---YLSREKLwICMEYC 97
Cdd:cd13988   1 LGQGATANVFRGRHKKTGDLYAVKVFNnlsfMRPLD----VQMREFEVlKKLNHKNIVKLFAIeeeLTTRHKV-LVMELC 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSL----QDIYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL--LTDHGDV--KLADFGvAAKITATI 169
Cdd:cd13988  76 PCGSLytvlEEPSNAYG-LPESEFLIVLRDVVAGMNHLRENGIVHRDIKPGNIMrvIGEDGQSvyKLTDFG-AARELEDD 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 170 AKRKSFIGTPYWMAP---EVAAVEKNGG--YNQLCDIWAVGIT 207
Cdd:cd13988 154 EQFVSLYGTEEYLHPdmyERAVLRKDHQkkYGATVDLWSIGVT 196
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
27-369 4.37e-17

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 83.22  E-value: 4.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHT---GELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05584   5 GKGGYGKVFQVRKTTGsdkGKIFAMKVLKkasiVRNQKDTAHTKAERNILEAVKHPFIVDLHYAFQTGGKLYLILEYLSG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTP 179
Cdd:cd05584  85 GELFMHLEREGIFMEDTACFYLAEITLALGHLHSLGIIYRDLKPENILLDAQGHVKLTDFGLCKESIHDGTVTHTFCGTI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 180 YWMAPEVAAvekNGGYNQLCDIWAvgitaieLGELqppMFDLhpmralflmskSNFQPPKLKDktkwsstfhnfvkialt 259
Cdd:cd05584 165 EYMAPEILT---RSGHGKAVDWWS-------LGAL---MYDM-----------LTGAPPFTAE----------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 260 kNPKKrpTAERLLTHTFVAQPGLSRAlAVELLDKV--NNPDNHAHYTEADDDDFEPHAIIRHtirstnrnaraertaseI 337
Cdd:cd05584 204 -NRKK--TIDKILKGKLNLPPYLTNE-ARDLLKKLlkRNVSSRLGSGPGDAEEIKAHPFFRH-----------------I 262
                       330       340       350
                ....*....|....*....|....*....|....*
gi 38570135 338 NFDKL---QFEPPLRKETEARDEMGLsSDPNFMLQ 369
Cdd:cd05584 263 NWDDLlakKVEPPFKPLLQSEEDVSQ-FDSKFTKQ 296
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
28-276 4.60e-17

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 81.93  E-value: 4.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  28 SGT--YGDVYKARNVhtgelaAVKIIKLEpgdDFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKLWICMEYCGGgSLQD 104
Cdd:cd13982  14 EGTivFRGTFDGRPV------AVKRLLPE---FFDFADREVQLLRESdEHPNVIRYFCTEKDRQFLYIALELCAA-SLQD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IyhVTGPL-------SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-----DHGDVKLADFGVAAKITatiAKR 172
Cdd:cd13982  84 L--VESPResklflrPGLEPVRLLRQIASGLAHLHSLNIVHRDLKPQNILIStpnahGNVRAMISDFGLCKKLD---VGR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFI------GTPYWMAPEVAAVEKNGGYNQLCDIWAVG--ITAIELGELQPpmFDLHPMRALFLMsKSNFQPPKLKDKT 244
Cdd:cd13982 159 SSFSrrsgvaGTSGWIAPEMLSGSTKRRQTRAVDIFSLGcvFYYVLSGGSHP--FGDKLEREANIL-KGKYSLDKLLSLG 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 245 KWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd13982 236 EHGPEAQDLIERMIDFDPEKRPSAEEVLNHPF 267
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
26-211 6.02e-17

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 81.93  E-value: 6.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14221   1 LGKGCFGQAIKVTHRETGEVMVMKeLIRFDEETQRTFLK-EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTG---PLSelQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT--------------A 167
Cdd:cd14221  80 IIKSMDshyPWS--QRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMVdektqpeglrslkkP 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 168 TIAKRKSFIGTPYWMAPEVAavekNG-GYNQLCDIWAVGITAIEL 211
Cdd:cd14221 158 DRKKRYTVVGNPYWMAPEMI----NGrSYDEKVDVFSFGIVLCEI 198
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
24-270 6.42e-17

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 81.67  E-value: 6.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYgdvYKARNVHTGELAAVKIIKLEPGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd13992   9 SHTGEPKY---VKKVGVYGGRTVAIKHITFSRTEKRT-ILQELNQLKELVHDNLNKFIGICINPPNIAVVTEYCTRGSLQ 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTG-PL-SELQIAYVcRETLQGLAYLH-TKGKMHRDIKGANILLTDHGDVKLADFGVA---------AKITATIAK 171
Cdd:cd13992  85 DVLLNREiKMdWMFKSSFI-KDIVKGMNYLHsSSIGYHGRLKSSNCLVDSRWVVKLTDFGLRnlleeqtnhQLDEDAQHK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 172 RKsfigtpYWMAPEV---AAVEKNGgyNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSS 248
Cdd:cd13992 164 KL------LWTAPELlrgSLLEVRG--TQKGDVYSFAIILYEILFRSDP-FALEREVAIVEKVISGGNKPFRPELAVLLD 234
                       250       260
                ....*....|....*....|....*.
gi 38570135 249 TFHN----FVKIALTKNPKKRPTAER 270
Cdd:cd13992 235 EFPPrlvlLVKQCWAENPEKRPSFKQ 260
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
20-271 6.52e-17

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 82.60  E-value: 6.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK--HCNIVAYFGSYLSREK-------- 89
Cdd:cd13977   2 YSLIREVGRGSYGVVYEAVVRRTGARVAVKKIRCNAPENVELALREFWALSSIQrqHPNVIQLEECVLQRDGlaqrmshg 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 ----------------------------LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETlQGLAYLHTKGKMHRDI 141
Cdd:cd13977  82 ssksdlylllvetslkgercfdprsacyLWFVMEFCDGGDMNEYLLSRRPDRQTNTSFMLQLS-SALAFLHRNQIVHRDL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 142 KGANILLTDHGD---VKLADFGVaAKITATIAKR--------KSFI----GTPYWMAPEVAavekNGGYNQLCDIWAVG- 205
Cdd:cd13977 161 KPDNILISHKRGepiLKVADFGL-SKVCSGSGLNpeepanvnKHFLssacGSDFYMAPEVW----EGHYTAKADIFALGi 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 206 --------ITAIE-------LGELQPPMFDLHPM-RALFLMSKSNFQPPkLKDKTKWSSTFHNFVKIALTKNPKKRPTAE 269
Cdd:cd13977 236 iiwamverITFRDgetkkelLGTYIQQGKEIVPLgEALLENPKLELQIP-LKKKKSMNDDMKQLLRDMLAANPQERPDAF 314

                ..
gi 38570135 270 RL 271
Cdd:cd13977 315 QL 316
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
16-271 6.59e-17

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 81.63  E-value: 6.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARnVHTGELAAVKIIKlePGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05072   5 PRESIKLVKKLGAGQFGEVWMGY-YNNSTKVAVKTLK--PGTmSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIIT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd05072  82 EYMAKGSLLDFLKSDegGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIEL---GELQ-PPMFDLHPMRALflmsKSNFQPPKLKDktkWS 247
Cdd:cd05072 162 REGAKFPIkWTAPEAINF---GSFTIKSDVWSFGILLYEIvtyGKIPyPGMSNSDVMSAL----QRGYRMPRMEN---CP 231
                       250       260
                ....*....|....*....|....
gi 38570135 248 STFHNFVKIALTKNPKKRPTAERL 271
Cdd:cd05072 232 DELYDIMKTCWKEKAEERPTFDYL 255
STKc_LATS2 cd05626
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs ...
23-223 6.94e-17

Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS2 is an essential mitotic regulator responsible for coordinating accurate cytokinesis completion and governing the stabilization of other mitotic regulators. It is also critical in the maintenance of proper chromosome number, genomic stability, mitotic fidelity, and the integrity of centrosome duplication. Downregulation of LATS2 is associated with poor prognosis in acute lymphoblastic leukemia and breast cancer. The LATS2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173715 [Multi-domain]  Cd Length: 381  Bit Score: 83.52  E-value: 6.94e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP---GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05626   6 IKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDvlnRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA---------------- 163
Cdd:cd05626  86 GDMMSLLIRMEVFPEVLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTgfrwthnskyyqkgsh 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 ------------------------KITATIAKRK-------SFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELG 212
Cdd:cd05626 166 irqdsmepsdlwddvsncrcgdrlKTLEQRATKQhqrclahSLVGTPNYIAPEVLLRK---GYTQLCDWWSVGVILFEML 242
                       250
                ....*....|.
gi 38570135 213 ELQPPMFDLHP 223
Cdd:cd05626 243 VGQPPFLAPTP 253
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
26-211 7.81e-17

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 81.53  E-value: 7.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVK-IIKLEPGDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14222   1 LGKGFFGQAIKVTHKATGKVMVMKeLIRCDEETQKTFLT-EVKVMRSLDHPNVLKFIGVLYKDKRLNLLTEFIEGGTLKD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT----------ATIAKRK- 173
Cdd:cd14222  80 FLRADDPFPWQQKVSFAKGIASGMAYLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVeekkkpppdkPTTKKRTl 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 174 ---------SFIGTPYWMAPEVAavekNG-GYNQLCDIWAVGITAIEL 211
Cdd:cd14222 160 rkndrkkryTVVGNPYWMAPEML----NGkSYDEKVDIFSFGIVLCEI 203
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
20-274 9.90e-17

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 80.90  E-value: 9.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14071   2 YDIERTIGKGNFAVVKLARHRITKTEVAIKIIDKSQLDEENLkkIYREVQIMKMLNHPHIIKLYQVMETKDMLYLVTEYA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiAKRKSFIG 177
Cdd:cd14071  82 SNGEIFDYLAQHGRMSEKEARKKFWQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPG-ELLKTWCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEKNGGyNQLcDIWAVGITAIEL--GELQppmFD---LHPMRALFLMSKsnFQPPKLKdktkwSSTFHN 252
Cdd:cd14071 161 SPPYAAPEVFEGKEYEG-PQL-DIWSLGVVLYVLvcGALP---FDgstLQTLRDRVLSGR--FRIPFFM-----STDCEH 228
                       250       260
                ....*....|....*....|..
gi 38570135 253 FVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14071 229 LIRRMLVLDPSKRLTIEQIKKH 250
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
20-277 1.28e-16

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 80.42  E-value: 1.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII-KLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSYLSRE-KLWICME 95
Cdd:cd14163   2 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIdKSGGPEEFiqRFLPRELQIVERLDHKNIIHVYEMLESADgKIYLVME 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHgDVKLADFGVAAKITATIAK-RKS 174
Cdd:cd14163  82 LAEDGDVFDCVLHGGPLPEHRAKALFRQLVEAIRYCHGCGVAHRDLKCENALLQGF-TLKLTDFGFAKQLPKGGRElSQT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEV-AAVEKNggyNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLkdktKWSSTFHNF 253
Cdd:cd14163 161 FCGSTAYAAPEVlQGVPHD---SRKGDIWSMGVVLYVMLCAQLPFDDTDIPKMLCQQQKGVSLPGHL----GVSRTCQDL 233
                       250       260
                ....*....|....*....|....
gi 38570135 254 VKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14163 234 LKRLLEPDMVLRPSIEEVSWHPWL 257
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
26-265 1.39e-16

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 81.59  E-value: 1.39e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIklepgddfsliQQEIFM---------------VKECKHCNIVAYFGSYLSREKL 90
Cdd:cd05575   3 IGKGSFGKVLLARHKAEGKLYAVKVL-----------QKKAILkrnevkhimaernvlLKNVKHPFLVGLHYSFQTKDKL 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV------A 162
Cdd:cd05575  72 YFVLDYVNGGEL--FFHLQRErhFPEPRARFYAAEIASALGYLHSLNIIYRDLKPENILLDSQGHVVLTDFGLckegieP 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKITATiakrksFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPP--------MFD--LHpmralflmsk 232
Cdd:cd05575 150 SDTTST------FCGTPEYLAPEVLRKQP---YDRTVDWWCLGAVLYEMLYGLPPfysrdtaeMYDniLH---------- 210
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 233 snfQPpkLKDKTKWSSTFHNFVKIALTKNPKKR 265
Cdd:cd05575 211 ---KP--LRLRTNVSPSARDLLEGLLQKDRTKR 238
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
20-279 1.41e-16

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 81.23  E-value: 1.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFSLiqqeifMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14175   3 YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIdksKRDPSEEIEI------LLRYGQHPNIITLKDVYDDGKHVYLVTEL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH-GD---VKLADFGVAAKITATIAKR 172
Cdd:cd14175  77 MRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYVDEsGNpesLRICDFGFAKQLRAENGLL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGI---------TAIELGELQPPMFDLHPM-RALFLMSKSNFQppklkd 242
Cdd:cd14175 157 MTPCYTANFVAPEVL---KRQGYDEGCDIWSLGIllytmlagyTPFANGPSDTPEEILTRIgSGKFTLSGGNWN------ 227
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 243 ktKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14175 228 --TVSDAAKDLVSKMLHVDPHQRLTAKQVLQHPWITQ 262
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
20-279 2.15e-16

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 80.29  E-value: 2.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14104   2 YMIAEELGRGQFGIVHRCVETSSKKTYMAKFVKVK-GADQVLVKKEISILNIARHRNILRLHESFESHEELVMIFEFISG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 gslQDIYHVTGP----LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH--GDVKLADFGVAAKITATIAKRK 173
Cdd:cd14104  81 ---VDIFERITTarfeLNEREIVSYVRQVCEALEFLHSKNIGHFDIRPENIIYCTRrgSYIKIIEFGQSRQLKPGDKFRL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIgTPYWMAPEVAAVEKNGgynQLCDIWAVG-ITAIELGELQPPMFDLHP-MRALFLMSKSNFQPPKLKDktkWSSTFH 251
Cdd:cd14104 158 QYT-SAEFYAPEVHQHESVS---TATDMWSLGcLVYVLLSGINPFEAETNQqTIENIRNAEYAFDDEAFKN---ISIEAL 230
                       250       260
                ....*....|....*....|....*...
gi 38570135 252 NFVKIALTKNPKKRPTAERLLTHTFVAQ 279
Cdd:cd14104 231 DFVDRLLVKERKSRMTAQEALNHPWLKQ 258
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
16-271 2.16e-16

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 80.07  E-value: 2.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKAR-NVHTGelAAVKIIKlePGD-DFSLIQQEIFMVKECKHCNIVAyFGSYLSREKLWIC 93
Cdd:cd05073   9 PRESLKLEKKLGAGQFGEVWMATyNKHTK--VAVKTMK--PGSmSVEAFLAEANVMKTLQHDKLVK-LHAVVTKEPIYII 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHVTG----PLSEL-----QIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd05073  84 TEFMAKGSLLDFLKSDEgskqPLPKLidfsaQIA-------EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIEL---GELQ-PPMFDLHPMRAL---FLMSKSNFQ 236
Cdd:cd05073 157 IEDNEYTAREGAKFPIkWTAPEAI---NFGSFTIKSDVWSFGILLMEIvtyGRIPyPGMSNPEVIRALergYRMPRPENC 233
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 237 PPKLKDktkwsstfhnfVKIALTKN-PKKRPTAERL 271
Cdd:cd05073 234 PEELYN-----------IMMRCWKNrPEERPTFEYI 258
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
20-277 2.29e-16

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 79.76  E-value: 2.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ--QEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14074   5 YDLEETLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDDVSKAHlfQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQD--IYHVTGpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD-HGDVKLADFGVAAKITATiAKRKS 174
Cdd:cd14074  85 DGGDMYDyiMKHENG-LNEDLARKYFRQIVSAISYCHKLHVVHRDLKPENVVFFEkQGLVKLTDFGFSNKFQPG-EKLET 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEV--------AAVeknggynqlcDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ-PPKLKDKTK 245
Cdd:cd14074 163 SCGSLAYSAPEIllgdeydaPAV----------DIWSLGVILYMLVCGQPPFQEANDSETLTMIMDCKYTvPAHVSPECK 232
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 246 wsstfhNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14074 233 ------DLIRRMLIRDPKKRASLEEIENHPWL 258
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
24-271 2.41e-16

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 80.21  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARnvHTGELAAVKI-IKLEPGDDFSliQQEIFMVKECKHCNIVAYFGSYL----SREKLWICMEYCG 98
Cdd:cd14144   1 RSVGKGRYGEVWKGK--WRGEKVAVKIfFTTEEASWFR--ETEIYQTVLMRHENILGFIAADIkgtgSWTQLYLITDYHE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIY--HVTGPLSELQIAYvcrETLQGLAYLH-----TKGK---MHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd14144  77 NGSLYDFLrgNTLDTQSMLKLAY---SAACGLAHLHteifgTQGKpaiAHRDIKSKNILVKKNGTCCIADLGLAVKFISE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAK----RKSFIGTPYWMAPEVAAVEKNGGYNQ---LCDIWAVGITAIELG----------ELQPPMFDLHP-------M 224
Cdd:cd14144 154 TNEvdlpPNTRVGTKRYMAPEVLDESLNRNHFDaykMADMYSFGLVLWEIArrcisggiveEYQLPYYDAVPsdpsyedM 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 38570135 225 RALFLMSKsnFQPPKlkdKTKWSS-----TFHNFVKIALTKNPKKRPTAERL 271
Cdd:cd14144 234 RRVVCVER--RRPSI---PNRWSSdevlrTMSKLMSECWAHNPAARLTALRV 280
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
26-223 2.91e-16

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 80.35  E-value: 2.91e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLEPG----DDFSliqQEIFMVKECKHCNIVAYFG-----SYLSREKLWICMEY 96
Cdd:cd14039   1 LGTGGFGNVCLYQNQETGEKIAIKSCRLELSvknkDRWC---HEIQIMKKLNHPNVVKACDvpeemNFLVNDVPLLAMEY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIyhVTGP-----LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDV---KLADFGVAAKITAT 168
Cdd:cd14039  78 CSGGDLRKL--LNKPenccgLKESQVLSLLSDIGSGIQYLHENKIIHRDLKPENIVLQEINGKivhKIIDLGYAKDLDQG 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 169 iAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIE-LGELQPPMFDLHP 223
Cdd:cd14039 156 -SLCTSFVGTLQYLAPELF---ENKSYTVTVDYWSFGTMVFEcIAGFRPFLHNLQP 207
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
24-186 3.24e-16

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 80.06  E-value: 3.24e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFsLIQQEIFMVKECKHCNIVAYFGSylsrEK--------LWICME 95
Cdd:cd14053   1 EIKARGRFGAVWKAQ--YLNRLVAVKIFPLQEKQSW-LTEREIYSLPGMKHENILQFIGA----EKhgesleaeYWLITE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVtgplSELQIAYVCR--ETL-QGLAYLHT----------KGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd14053  74 FHERGSLCDYLKG----NVISWNELCKiaESMaRGLAYLHEdipatngghkPSIAHRDFKSKNVLLKSDLTACIADFGLA 149
                       170       180
                ....*....|....*....|....*.
gi 38570135 163 AKITATIAKRKSF--IGTPYWMAPEV 186
Cdd:cd14053 150 LKFEPGKSCGDTHgqVGTRRYMAPEV 175
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
15-162 3.25e-16

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 80.28  E-value: 3.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlePGDDFSlIQQEIFMVKE-CKHCNIVAYFGS---YLSREKL 90
Cdd:cd14132  15 GSQDDYEIIRKIGRGKYSEVFEGINIGNNEKVVIKVLK--PVKKKK-IKREIKILQNlRGGPNIVKLLDVvkdPQSKTPS 91
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38570135  91 WIcMEYCGGGSLQDIYHVtgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIlLTDHG--DVKLADFGVA 162
Cdd:cd14132  92 LI-FEYVNNTDFKTLYPT---LTDYDIRYYMYELLKALDYCHSKGIMHRDVKPHNI-MIDHEkrKLRLIDWGLA 160
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
16-271 4.00e-16

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 79.16  E-value: 4.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKA-RNVHTgelaAVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFgSYLSREKLWIC 93
Cdd:cd05067   5 PRETLKLVERLGAGQFGEVWMGyYNGHT----KVAIKSLKQGSmSPDAFLAEANLMKQLQHQRLVRLY-AVVTQEPIYII 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDiYHVTGPLSELQIAYVCRETLQ---GLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd05067  80 TEYMENGSLVD-FLKTPSGIKLTINKLLDMAAQiaeGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIEL---GELQ-PPMFDLHPMRAL---FLMSKSNFQPPKLkd 242
Cdd:cd05067 159 TAREGAKFPIkWTAPEAI---NYGTFTIKSDVWSFGILLTEIvthGRIPyPGMTNPEVIQNLergYRMPRPDNCPEEL-- 233
                       250       260
                ....*....|....*....|....*....
gi 38570135 243 ktkwsstfHNFVKIALTKNPKKRPTAERL 271
Cdd:cd05067 234 --------YQLMRLCWKERPEDRPTFEYL 254
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
65-219 4.63e-16

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 81.04  E-value: 4.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   65 EIFMVKECKHCNIVAYFGSYlsREKLWICM---EYcgggsLQDIY---HVTGPLSELQIAYVCRETLQGLAYLHTKGKMH 138
Cdd:PHA03207 136 EIDILKTISHRAIINLIHAY--RWKSTVCMvmpKY-----KCDLFtyvDRSGPLPLEQAITIQRRLLEALAYLHGRGIIH 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  139 RDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF--IGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQP 216
Cdd:PHA03207 209 RDVKTENIFLDEPENAVLGDFGAACKLDAHPDTPQCYgwSGTLETNSPELLALDP---YCAKTDIWSAGLVLFEMSVKNV 285

                 ...
gi 38570135  217 PMF 219
Cdd:PHA03207 286 TLF 288
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
18-211 4.65e-16

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 80.48  E-value: 4.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlEPGDdfSLIQ-----QEIFMVKECKHCNIVAYFGSYLSReklwi 92
Cdd:cd07878  15 ERYQNLTPVGSGAYGSVCSAYDTRLRQKVAVKKLS-RPFQ--SLIHarrtyRELRLLKHMKHENVIGLLDVFTPA----- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 cmeyCGGGSLQDIYHVTG-------------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159
Cdd:cd07878  87 ----TSIENFNEVYLVTNlmgadlnnivkcqKLSDEHVQFLIYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDF 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 38570135 160 GVAAKitaTIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIEL 211
Cdd:cd07878 163 GLARQ---ADDEMTGYVATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAEL 209
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
12-211 5.92e-16

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 79.00  E-value: 5.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  12 LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELA----AVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGSYLS 86
Cdd:cd05057   1 LRIVKETELEKGKVLGSGAFGTVYKGVWIPEGEKVkipvAIKVLREETGpKANEEILDEAYVMASVDHPHLVRLLGICLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 rEKLWICMEYCGGGSLQDiyHV---TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd05057  81 -SQVQLITQLMPLGCLLD--YVrnhRDNIGSQLLLNWCVQIAKGMSYLEEKRLVHRDLAARNVLVKTPNHVKITDFGLAK 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 164 KITatiAKRKSFIGT----PY-WMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05057 158 LLD---VDEKEYHAEggkvPIkWMALESI---QYRIYTHKSDVWSYGVTVWEL 204
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
18-274 6.25e-16

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 79.04  E-value: 6.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELV--QRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDdfsliQQEIFMVKECK-HCNIVAYFGSY---------- 84
Cdd:cd14171   4 EEYEVNwtQKLGTGISGPVRVCVKKSTGERFALKILLDRPKA-----RTEVRLHMMCSgHPNIVQIYDVYansvqfpges 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGV 161
Cdd:cd14171  79 SPRARLLIVMELMEGGELFDRISQHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLKPENLLLKDNSEdapIKLCDFGF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 aAKITATIAKRKSFigTPYWMAPEVAAV------EKNGG--------YNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Cdd:cd14171 159 -AKVDQGDLMTPQF--TPYYVAPQVLEAqrrhrkERSGIptsptpytYDKSCDMWSLGVIIYIMLCGYPPFYSEHPSRTI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 228 F------LMSKSnFQPPKlKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14171 236 TkdmkrkIMTGS-YEFPE-EEWSQISEMAKDIVRKLLCVDPEERMTIEEVLHH 286
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
26-265 6.99e-16

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 78.88  E-value: 6.99e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKI-----IKLEPGDDFSLIQQEIFMVKECKHCNIVAYfgSYLSREKLWICMEYCGGG 100
Cdd:cd05631   8 LGKGGFGEVCACQVRATGKMYACKKlekkrIKKRKGEAMALNEKRILEKVNSRFVVSLAY--AYETKDALCLVLTIMNGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT--ATIAKRksfI 176
Cdd:cd05631  86 DLKfHIYNMGNPgFDEQRAIFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPegETVRGR---V 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKI 256
Cdd:cd05631 163 GTVGYMAPEVI---NNEKYTFSPDWWGLGCLIYEMIQGQSP-FRKRKERVKREEVDRRVKEDQEEYSEKFSEDAKSICRM 238

                ....*....
gi 38570135 257 ALTKNPKKR 265
Cdd:cd05631 239 LLTKNPKER 247
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
6-219 7.13e-16

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 80.82  E-value: 7.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   6 RPAADILR--RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVK-ECKHCNIV 78
Cdd:cd05624  58 KPFTQLVKemQLHRDDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNkwemLKRAETACFREERNVLVNgDCQWITTL 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  79 AYfgSYLSREKLWICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLA 157
Cdd:cd05624 138 HY--AFQDENYLYLVMDYYVGGDLLTLLsKFEDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLA 215
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 158 DFGVAAKITATIAKRKSF-IGTPYWMAPEV--AAVEKNGGYNQLCDIWAVGITAIELGELQPPMF 219
Cdd:cd05624 216 DFGSCLKMNDDGTVQSSVaVGTPDYISPEIlqAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY 280
STKc_Unc-89_rpt2 cd14112
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated ...
16-277 8.22e-16

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271014 [Multi-domain]  Cd Length: 259  Bit Score: 78.34  E-value: 8.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKA--RNVHTGELAAVKIikLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd14112   1 PTGRFSFGSEIFRGRFSVIVKAvdSTTETDAHCAVKI--FEVSDEASEAVREFESLRTLQHENVQRLIAAFKPSNFAYLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGG-----SLQDIYhvtgplSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD--VKLADFGVAAKIT 166
Cdd:cd14112  79 MEKLQEDvftrfSSNDYY------SEEQVATTVRQILDALHYLHFKGIAHLDVQPDNIMFQSVRSwqVKLVDFGRAQKVS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 AtiAKRKSFIGTPYWMAPEVAAVEKNgGYNQlCDIWAVGITAIELgelqppMFDLHPMRA------------LFLMSKSN 234
Cdd:cd14112 153 K--LGKVPVDGDTDWASPEFHNPETP-ITVQ-SDIWGLGVLTFCL------LSGFHPFTSeyddeeetkenvIFVKCRPN 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 235 FQPpklKDKTKWSStfhNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14112 223 LIF---VEATQEAL---RFATWALKKSPTRRMRTDEALEHRWL 259
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
20-276 8.89e-16

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 78.28  E-value: 8.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPgDDF--SLIQQEIFMVKECKHCNIVAYFGSY-LSREKLWICM 94
Cdd:cd14165   3 YILGINLGEGSYAKVKSAYSERLKCNVAIKIIdkKKAP-DDFveKFLPRELEILARLNHKSIIKTYEIFeTSDGKVYIVM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI----TATIA 170
Cdd:cd14165  82 ELGVQGDLLEFIKLRGALPEDVARKMFHQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRClrdeNGRIV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGIT--AIELGELQPPMFDLHPMRALFLMSKSNFQPPKlkdktKWSS 248
Cdd:cd14165 162 LSKTFCGSAAYAAPEV--LQGIPYDPRIYDIWSLGVIlyIMVCGSMPYDDSNVKKMLKIQKEHRVRFPRSK-----NLTS 234
                       250       260
                ....*....|....*....|....*...
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14165 235 ECKDLIYRLLQPDVSQRLCIDEVLSHPW 262
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
16-271 9.22e-16

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 78.22  E-value: 9.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKAR-NVHTGelAAVKiiKLEPG----DDFsliQQEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd05068   6 DRKSLKLLRKLGSGQFGEVWEGLwNNTTP--VAVK--TLKPGtmdpEDF---LREAQIMKKLRHPKLIQLYAVCTLEEPI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDIYHvtGPLSELQIAYVCRETLQ---GLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITA 167
Cdd:cd05068  79 YIITELMKHGSLLEYLQ--GKGRSLQLPQLIDMAAQvasGMAYLESQNYIHRDLAARNVLVGENNICKVADFGL-ARVIK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPY---WMAPEVAAveknggYNQLC---DIWAVGITAIEL---GELQ-PPMFD---LHPMRALFLMSKSN 234
Cdd:cd05068 156 VEDEYEAREGAKFpikWTAPEAAN------YNRFSiksDVWSFGILLTEIvtyGRIPyPGMTNaevLQQVERGYRMPCPP 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 235 FQPPKLKDktkwsstfhnfvkIAL---TKNPKKRPTAERL 271
Cdd:cd05068 230 NCPPQLYD-------------IMLecwKADPMERPTFETL 256
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
20-274 1.18e-15

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 77.66  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ------QEIFMVKEC---KHCNIVAYFGSYLSREKL 90
Cdd:cd14005   2 YEVGDLLGKGGFGTVYSGVRIRDGLPVAVKFVPKSRVTEWAMINgpvpvpLEIALLLKAskpGVPGVIRLLDWYERPDGF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEY---CGggSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-DHGDVKLADFGVAAKIT 166
Cdd:cd14005  82 LLIMERpepCQ--DLFDFITERGALSENLARIIFRQVVEAVRHCHQRGVLHRDIKDENLLINlRTGEVKLIDFGCGALLK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIakRKSFIGTPYWMAPEV----------AAVeknggynqlcdiWAVGITAIEL--GELqPPMFDLHPMRALFLmsksn 234
Cdd:cd14005 160 DSV--YTDFDGTRVYSPPEWirhgryhgrpATV------------WSLGILLYDMlcGDI-PFENDEQILRGNVL----- 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 38570135 235 FQPpklkdktKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14005 220 FRP-------RLSKECCDLISRCLQFDPSKRPSLEQILSH 252
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
26-276 1.61e-15

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 78.17  E-value: 1.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTG------ELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM----E 95
Cdd:cd14030  33 IGRGSFKTVYKGLDTETTvevawcELQDRKLSKSER----QRFKEEAGMLKGLQHPNIVRFYDSWESTVKGKKCIvlvtE 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTD-HGDVKLADFGVAAKITATIAkr 172
Cdd:cd14030 109 LMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPpiIHRDLKCDNIFITGpTGSVKIGDLGLATLKRASFA-- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAAvEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLkDKTKWSSTfHN 252
Cdd:cd14030 187 KSVIGTPEFMAPEMYE-EK---YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASF-DKVAIPEV-KE 260
                       250       260
                ....*....|....*....|....
gi 38570135 253 FVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14030 261 IIEGCIRQNKDERYAIKDLLNHAF 284
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
24-206 1.75e-15

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 77.28  E-value: 1.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL 102
Cdd:cd05084   2 ERIGRGNFGEVFSGRLRADNTPVAVKSCRETlPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK-----ITATIAKRKSFI 176
Cdd:cd05084  82 LTFLRTEGPrLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREeedgvYAATGGMKQIPV 161
                       170       180       190
                ....*....|....*....|....*....|
gi 38570135 177 GtpyWMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd05084 162 K---WTAPEAL---NYGRYSSESDVWSFGI 185
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
24-223 1.80e-15

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 77.87  E-value: 1.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYkaRNVHTGELAAVKIIKLEpgDDFSLIQQ-EIFMVKECKHCNIVAYF-------GSYlsrEKLWICME 95
Cdd:cd14143   1 ESIGKGRFGEVW--RGRWRGEDVAVKIFSSR--EERSWFREaEIYQTVMLRHENILGFIaadnkdnGTW---TQLWLVSD 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDiYHVTGPLSELQIAYVCRETLQGLAYLH-----TKGK---MHRDIKGANILLTDHGDVKLADFGVAAK--- 164
Cdd:cd14143  74 YHEHGSLFD-YLNRYTVTVEGMIKLALSIASGLAHLHmeivgTQGKpaiAHRDLKSKNILVKKNGTCCIADLGLAVRhds 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 165 ITATI-AKRKSFIGTPYWMAPEVaaVEKNGGYNQLC-----DIWAVGITAIELG----------ELQPPMFDLHP 223
Cdd:cd14143 153 ATDTIdIAPNHRVGTKRYMAPEV--LDDTINMKHFEsfkraDIYALGLVFWEIArrcsiggiheDYQLPYYDLVP 225
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
20-278 2.11e-15

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 77.75  E-value: 2.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII---KLEPGDDFsliqqEIFMvKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd14177   6 YELKEDIGVGSYSVCKRCIHRATNMEFAVKIIdksKRDPSEEI-----EILM-RYGQHPNIITLKDVYDDGRYVYLVTEL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG----DVKLADFGVAAKITATIAKR 172
Cdd:cd14177  80 MKGGELLDRILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMDDSanadSIRICDFGFAKQLRGENGLL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGITAIELGELQPPMF---DLHPMRALFLMSKSNFQppklKDKTKW--- 246
Cdd:cd14177 160 LTPCYTANFVAPEVLMRQ---GYDAACDIWSLGVLLYTMLAGYTPFAngpNDTPEEILLRIGSGKFS----LSGGNWdtv 232
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd14177 233 SDAAKDLLSHMLHVDPHQRYTAEQVLKHSWIA 264
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
25-216 2.24e-15

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 78.19  E-value: 2.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQ-QEIFMVKECKHCNIVAYFGSYLSR--EKLWICMEYcgggS 101
Cdd:cd07867   9 KVGRGTYGHVYKAKRKDGKDEKEYALKQIE-GTGISMSAcREIALLRELKHPNVIALQKVFLSHsdRKVWLLFDY----A 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTG------------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT----DHGDVKLADFGVAAKI 165
Cdd:cd07867  84 EHDLWHIIKfhraskankkpmQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMgegpERGRVKIADMGFARLF 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 38570135 166 TA---TIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07867 164 NSplkPLADLDPVVVTFWYRAPELLLGARH--YTKAIDIWAIGCIFAELLTSEP 215
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
16-206 2.30e-15

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 77.09  E-value: 2.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAaVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05148   4 PREEFTLERKLGSGYFGEVWEGLWKNRVRVA-IKILKSDDLLKQQDFQKEVQALKRLRHKHLISLFAVCSVGEPVYIITE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQdIYHVTGPLSELQIA---YVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd05148  83 LMEKGSLL-AFLRSPEGQVLPVAsliDMACQVAEGMAYLEEQNSIHRDLAARNILVGEDLVCKVADFGLARLIKEDVYLS 161
                       170       180       190
                ....*....|....*....|....*....|....*
gi 38570135 173 KSfIGTPY-WMAPEVAAvekNGGYNQLCDIWAVGI 206
Cdd:cd05148 162 SD-KKIPYkWTAPEAAS---HGTFSTKSDVWSFGI 192
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
26-238 2.47e-15

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 76.80  E-value: 2.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnvHTGELAAVKIIKLEP---GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSR-EKLWICMEYCGGGS 101
Cdd:cd14064   1 IGSGSFGKVYKGR--CRNKIVAIKRYRANTycsKSDVDMFCREVSILCRLNHPCVIQFVGACLDDpSQFAIVTQYVSGGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYH----VTGPLSELQIAYvcrETLQGLAYLH--TKGKMHRDIKGANILLTDHGDVKLADFG----VAAKITATIAK 171
Cdd:cd14064  79 LFSLLHeqkrVIDLQSKLIIAV---DVAKGMEYLHnlTQPIIHRDLNSHNILLYEDGHAVVADFGesrfLQSLDEDNMTK 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 172 RKsfiGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIEL--GELqpPMFDLHPMRALFLMSKSNFQPP 238
Cdd:cd14064 156 QP---GNLRWMAPEV--FTQCTRYSIKADVFSYALCLWELltGEI--PFAHLKPAAAAADMAYHHIRPP 217
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
20-206 2.52e-15

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 77.14  E-value: 2.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDV-----YKARNVHTGELAAVKIIK---LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd14076   3 YILGRTLGEGEFGKVklgwpLPKANHRSGVQVAIKLIRrdtQQENCQTSKIMREINILKGLTHPNIVRLLDVLKTKKYIG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK 171
Cdd:cd14076  83 IVLEFVSGGELFDYILARRRLKDSVACRLFAQLISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFANTFDHFNGD 162
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 38570135 172 -RKSFIGTPYWMAPEVaAVEKNGGYNQLCDIWAVGI 206
Cdd:cd14076 163 lMSTSCGSPCYAAPEL-VVSDSMYAGRKADIWSCGV 197
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
24-211 3.03e-15

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 76.69  E-value: 3.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFsliQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05052  12 HKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDtmEVEEF---LKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMPYGN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTP 179
Cdd:cd05052  89 LLDYLRECNReeLNAVVLLYMATQIASAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 168
                       170       180       190
                ....*....|....*....|....*....|...
gi 38570135 180 Y-WMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05052 169 IkWTAPESLAYNK---FSIKSDVWAFGVLLWEI 198
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
26-211 3.81e-15

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 76.38  E-value: 3.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARnVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14664   1 IGRGGAGTVYKGV-MPNGTLVAVKRLKGEGTQGGDHgFQAEIQTLGMIRHRNIVRLRGYCSNPTTNLLVYEYMPNGSLGE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYHVTGPLSE-LQIAYVCRETLQ---GLAYLHTKGK---MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI- 176
Cdd:cd14664  80 LLHSRPESQPpLDWETRQRIALGsarGLAYLHHDCSpliIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDSHVMSSVa 159
                       170       180       190
                ....*....|....*....|....*....|....*
gi 38570135 177 GTPYWMAPEVAAVEKNggyNQLCDIWAVGITAIEL 211
Cdd:cd14664 160 GSYGYIAPEYAYTGKV---SEKSDVYSYGVVLLEL 191
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
26-220 3.91e-15

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 77.23  E-value: 3.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKL-----EPGDDFSLIQQEIFMVKECKHcnIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd05585   2 IGKGSFGKVMQVRKKDTSRIYALKTIRKahivsRSEVTHTLAERTVLAQVDCPF--IVPLKFSFQSPEKLYLVLAFINGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLqdIYHVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGT 178
Cdd:cd05585  80 EL--FHHLQreGRFDLSRARFYTAELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMKDDDKTNTFCGT 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 38570135 179 PYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFD 220
Cdd:cd05585 158 PEYLAPELLL---GHGYTKAVDWWTLGVLLYEMLTGLPPFYD 196
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
21-211 3.93e-15

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 76.55  E-value: 3.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDVYKARnvHTGELAaVKIIKLEPG--DDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14152   3 ELGELIGQGRWGKVHRGR--WHGEVA-IRLLEIDGNnqDHLKLFKKEVMNYRQTRHENVVLFMGACMHPPHLAIITSFCK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIyhVTGPLSELQI---AYVCRETLQGLAYLHTKGKMHRDIKGANILLtDHGDVKLADFGVAAkITATI--AKRK 173
Cdd:cd14152  80 GRTLYSF--VRDPKTSLDInktRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFY-DNGKVVITDFGLFG-ISGVVqeGRRE 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 174 SFIGTP----YWMAPEVAAVEKNGG------YNQLCDIWAVGITAIEL 211
Cdd:cd14152 156 NELKLPhdwlCYLAPEIVREMTPGKdedclpFSKAADVYAFGTIWYEL 203
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
16-281 4.13e-15

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 76.65  E-value: 4.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAavkIIKLEPGDDF-SLIQQEIFMVKECKHCNIVAYFgSYLSREKLWICM 94
Cdd:cd05069  10 PRESLRLDVKLGQGCFGEVWMGTWNGTTKVA---IKTLKPGTMMpEAFLQEAQIMKKLRHDKLVPLY-AVVSEEPIYIVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIY------HVTGPlselQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd05069  86 EFMGKGSLLDFLkegdgkYLKLP----QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIEL---GELQ-PPMFDlhpmRALFLMSKSNFQPPKLKDk 243
Cdd:cd05069 162 EYTARQGAKFPIkWTAPEAALY---GRFTIKSDVWSFGILLTELvtkGRVPyPGMVN----REVLEQVERGYRMPCPQG- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 244 tkWSSTFHNFVKIALTKNPKKRPTAERL---LTHTFVA-----QPG 281
Cdd:cd05069 234 --CPESLHELMKLCWKKDPDERPTFEYIqsfLEDYFTAtepqyQPG 277
STKc_LATS1 cd05625
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the ...
23-309 4.16e-15

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumor suppressor and is implicated in cell cycle regulation. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes. The LATS1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270775 [Multi-domain]  Cd Length: 382  Bit Score: 78.16  E-value: 4.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP---GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05625   6 IKTLGIGAFGEVCLARKVDTKALYATKTLRKKDvllRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITAT----------- 168
Cdd:cd05625  86 GDMMSLLIRMGVFPEDLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWThdskyyqsgdh 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 -----------------------------IAKRK-------SFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELG 212
Cdd:cd05625 166 lrqdsmdfsnewgdpencrcgdrlkplerRAARQhqrclahSLVGTPNYIAPEVLL---RTGYTQLCDWWSVGVILFEML 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 213 ELQPPMFDLHPMRAlfLMSKSNFQ-----PPKLKDKTKWSSTFhnfvkIALTKNPKKR---PTAERLLTHTFVAQPGLS- 283
Cdd:cd05625 243 VGQPPFLAQTPLET--QMKVINWQtslhiPPQAKLSPEASDLI-----IKLCRGPEDRlgkNGADEIKAHPFFKTIDFSs 315
                       330       340
                ....*....|....*....|....*...
gi 38570135 284 --RALAVELLDKVNNPDNHAHYTEADDD 309
Cdd:cd05625 316 dlRQQSAPYIPKITHPTDTSNFDPVDPD 343
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
16-281 4.18e-15

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 76.65  E-value: 4.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYkaRNVHTGElAAVKIIKLEPG--DDFSLIQQEIFMvKECKHCNIVAYFgSYLSREKLWIC 93
Cdd:cd05070   7 PRESLQLIKRLGNGQFGEVW--MGTWNGN-TKVAIKTLKPGtmSPESFLEEAQIM-KKLKHDKLVQLY-AVVSEEPIYIV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDIYHvTGPLSELQIAYVCRETLQ---GLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd05070  82 TEYMSKGSLLDFLK-DGEGRALKLPNLVDMAAQvaaGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 171 KRKSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIEL---GELQPPMFDlhpMRALFLMSKSNFQPPKLKDktkW 246
Cdd:cd05070 161 TARQGAKFPIkWTAPEAALY---GRFTIKSDVWSFGILLTELvtkGRVPYPGMN---NREVLEQVERGYRMPCPQD---C 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERL---LTHTFVA-----QPG 281
Cdd:cd05070 232 PISLHELMIHCWKKDPEERPTFEYLqgfLEDYFTAtepqyQPG 274
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
26-211 4.33e-15

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 77.06  E-value: 4.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVH---TGELAAVKIIK---LEPGDDF-SLIQQEIFMvkECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd05582   3 LGQGSFGKVFLVRKITgpdAGTLYAMKVLKkatLKVRDRVrTKMERDILA--DVNHPFIVKLHYAFQTEGKLYLILDFLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSL------------QDiyhVTGPLSELQIAyvcretlqgLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd05582  81 GGDLftrlskevmfteED---VKFYLAELALA---------LDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESI 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 167 ATIAKRKSFIGTPYWMAPEVaaVEKNgGYNQLCDIWAVGITAIEL 211
Cdd:cd05582 149 DHEKKAYSFCGTVEYMAPEV--VNRR-GHTQSADWWSFGVLMFEM 190
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
16-216 6.41e-15

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 75.84  E-value: 6.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYK--ARNVHTGEL---AAVKIIKLEP--GDDFSLIQQEIFMvKECKHCNIVAYFGSYLSRE 88
Cdd:cd05032   4 PREKITLIRELGQGSFGMVYEglAKGVVKGEPetrVAIKTVNENAsmRERIEFLNEASVM-KEFNCHHVVRLLGVVSTGQ 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQ----------DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLAD 158
Cdd:cd05032  83 PTLVVMELMAKGDLKsylrsrrpeaENNPGLGPPTLQKFIQMAAEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGD 162
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135 159 FGVAAKITATIAKRKSFIGT-PY-WMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL--QP 216
Cdd:cd05032 163 FGMTRDIYETDYYRKGGKGLlPVrWMAPESL---KDGVFTTKSDVWSFGVVLWEMATLaeQP 221
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
26-211 7.56e-15

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 76.02  E-value: 7.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTgeLAAVKIIKLEPGDDFSLIQQ----EIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd14159   1 IGEGGFGCVYQAVMRNT--EYAVKRLKEDSELDWSVVKNsfltEVEKLSRFRHPNIVDLAGYSAQQGNYCLIYVYLPNGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTG---PLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTDHGDVKLADFGVA--------AKITAT 168
Cdd:cd14159  79 LEDRLHCQVscpCLSWSQRLHVLLGTARAIQYLHSDSPslIHGDVKSSNILLDAALNPKLGDFGLArfsrrpkqPGMSST 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 169 IAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14159 159 LARTQTVRGTLAYLPEEYV---KTGTLSVEIDVYSFGVVLLEL 198
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
17-273 8.16e-15

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 75.54  E-value: 8.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNV-HTGEL--AAVKIIKLE-PGDDFSLIQQEIFMVKECKHCNIVAYFGsYLSREKLWI 92
Cdd:cd05056   5 REDITLGRCIGEGQFGDVYQGVYMsPENEKiaVAVKTCKNCtSPSVREKFLQEAYIMRQFDHPHIVKLIG-VITENPVWI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSL--------QDIYHVTGPLSELQIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK 164
Cdd:cd05056  84 VMELAPLGELrsylqvnkYSLDLASLILYAYQLS-------TALAYLESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 ITATIAKRKSFIGTPY-WMAPEVAAVEKnggYNQLCDIWAVG----------------------ITAIELGElQPPMFDL 221
Cdd:cd05056 157 MEDESYYKASKGKLPIkWMAPESINFRR---FTSASDVWMFGvcmweilmlgvkpfqgvknndvIGRIENGE-RLPMPPN 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 38570135 222 HPMRALFLMSKSnfqppklkdktkWSStfhnfvkialtkNPKKRPTAERLLT 273
Cdd:cd05056 233 CPPTLYSLMTKC------------WAY------------DPSKRPRFTELKA 260
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
20-285 9.37e-15

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 76.36  E-value: 9.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYL---SRE--KLWI 92
Cdd:cd07859   2 YKIQEVIGKGSYGVVCSAIDTHTGEKVAIKKINdvFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLppsRREfkDIYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGggslQDIYHVTGP---LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG---VAAKIT 166
Cdd:cd07859  82 VFELME----SDLHQVIKAnddLTPEHHQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGlarVAFNDT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKSFIGTPYWMAPEVAAvEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPP-------- 238
Cdd:cd07859 158 PTAIFWTDYVATRWYRAPELCG-SFFSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLITDLLGTPSpetisrvr 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 239 -----------KLKDKTKWSSTFHNFVKIA-------LTKNPKKRPTAERLLTHTFVAqpGLSRA 285
Cdd:cd07859 237 nekarrylssmRKKQPVPFSQKFPNADPLAlrllerlLAFDPKDRPTAEEALADPYFK--GLAKV 299
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
16-267 9.49e-15

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 75.78  E-value: 9.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYK--ARNVHTGEL---AAVKIIklepgDDFSLIQQEIFMVKE--------CKHcnIVAYFG 82
Cdd:cd05061   4 SREKITLLRELGQGSFGMVYEgnARDIIKGEAetrVAVKTV-----NESASLRERIEFLNEasvmkgftCHH--VVRLLG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  83 SYLSREKLWICMEYCGGGSLQDIYHVTGPLSE----------LQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG 152
Cdd:cd05061  77 VVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEnnpgrppptlQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 153 DVKLADFGVAAKITATIAKRKSFIG-TPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRAL-F 228
Cdd:cd05061 157 TVKIGDFGMTRDIYETDYYRKGGKGlLPVrWMAPESL---KDGVFTTSSDMWSFGVVLWEITSLaEQPYQGLSNEQVLkF 233
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 38570135 229 LMSKSNFQPPKlkdktKWSSTFHNFVKIALTKNPKKRPT 267
Cdd:cd05061 234 VMDGGYLDQPD-----NCPERVTDLMRMCWQFNPKMRPT 267
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
26-265 1.03e-14

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 75.33  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII-----KLEPGDDFSLIQQEIfmVKECKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd05607  10 LGKGGFGEVCAVQVKNTGQMYACKKLdkkrlKKKSGEKMALLEKEI--LEKVNSPFIVSLAYAFETKTHLCLVMSLMNGG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQ-DIYHVTGPLSEL-QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT--ATIAKRKsfi 176
Cdd:cd05607  88 DLKyHIYNVGERGIEMeRVIFYSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAVEVKegKPITQRA--- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 GTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMralflMSKSNFQPPKLKDKTK-----WSSTFH 251
Cdd:cd05607 165 GTNGYMAPEIL---KEESYSYPVDWFAMGCSIYEMVAGRTPFRDHKEK-----VSKEELKRRTLEDEVKfehqnFTEEAK 236
                       250
                ....*....|....
gi 38570135 252 NFVKIALTKNPKKR 265
Cdd:cd05607 237 DICRLFLAKKPENR 250
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
24-267 1.06e-14

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 75.22  E-value: 1.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQ--QEIFMVKECKHCNIVAYFGsyLSREKLWICMEYCGGGS 101
Cdd:cd14025   2 EKVGSGGFGQVYKVRHKHWKTWLAIKCPPSLHVDDSERMEllEEAKKMEMAKFRHILPVYG--ICSEPVGLVMEYMETGS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYhVTGPLS---ELQIAYvcrETLQGLAYLHTKGK--MHRDIKGANILLTDHGDVKLADFGVA---AKITATIAKRK 173
Cdd:cd14025  80 LEKLL-ASEPLPwelRFRIIH---ETAVGMNFLHCMKPplLHLDLKPANILLDAHYHVKISDFGLAkwnGLSHSHDLSRD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTPYWMAPEVaAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Cdd:cd14025 156 GLRGTIAYLPPER-FKEKNRCPDTKHDVYSFAIVIWGILTQKKPFAGENNILHIMVKVVKGHRPSLSPIPRQRPSECQQM 234
                       250
                ....*....|....*..
gi 38570135 254 VKI---ALTKNPKKRPT 267
Cdd:cd14025 235 ICLmkrCWDQDPRKRPT 251
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
12-219 1.50e-14

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 77.00  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   12 LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgddfSLIQQEIFMVKECKHCNIV-----AYFGSYLS 86
Cdd:PTZ00036  60 INRSPNKSYKLGNIIGNGSFGVVYEAICIDTSEKVAIKKVLQDP----QYKNRELLIMKNLNHINIIflkdyYYTECFKK 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   87 REK---LWICMEYCGGGSLQDIYHVT---GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG-DVKLADF 159
Cdd:PTZ00036 136 NEKnifLNVVMEFIPQTVHKYMKHYArnnHALPLFLVKLYSYQLCRALAYIHSKFICHRDLKPQNLLIDPNThTLKLCDF 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  160 GVAAKITATiAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELgELQPPMF 219
Cdd:PTZ00036 216 GSAKNLLAG-QRSVSYICSRFYRAPELMLGATN--YTTHIDLWSLGCIIAEM-ILGYPIF 271
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
23-211 1.70e-14

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 74.97  E-value: 1.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDV----YKARNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGsylsreklwIC---- 93
Cdd:cd05079   9 IRDLGEGHFGKVelcrYDPEGDNTGEQVAVKSLKPESGGNHIAdLKKEIEILRNLYHENIVKYKG---------ICtedg 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 -------MEYCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvaakI 165
Cdd:cd05079  80 gngikliMEFLPSGSLKEyLPRNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFG----L 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 166 TATIAKRKSF------IGTP-YWMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05079 156 TKAIETDKEYytvkddLDSPvFWYAPECLIQSK---FYIASDVWSFGVTLYEL 205
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
23-211 1.77e-14

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 74.93  E-value: 1.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDV----YKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLS--REKLWICMEY 96
Cdd:cd05081   9 ISQLGKGNFGSVelcrYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGpgRRSLRLVMEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIY----HVTGPLSELQIAY-VCRetlqGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaK 171
Cdd:cd05081  89 LPSGCLRDFLqrhrARLDASRLLLYSSqICK----GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--K 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 172 RKSFIGTP-----YWMAPEVAAvekNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05081 163 DYYVVREPgqspiFWYAPESLS---DNIFSRQSDVWSFGVVLYEL 204
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
26-311 1.88e-14

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 75.44  E-value: 1.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGE-------LAAVKIIKLEPGD-DFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd05100  20 LGEGCFGQVVMAEAIGIDKdkpnkpvTVAVKMLKDDATDkDLSDLVSEMEMMKMIgKHKNIINLLGACTQDGPLYVLVEY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGP-----------LSELQIAY-----VCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG 160
Cdd:cd05100 100 ASKGNLREYLRARRPpgmdysfdtckLPEEQLTFkdlvsCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 161 VAAKITATIAKRKSFIGT-PY-WMAPEvAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPP 238
Cdd:cd05100 180 LARDVHNIDYYKKTTNGRlPVkWMAPE-ALFDRV--YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 256
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 239 KLKDKTKwssTFHNFVKIALTKNPKKRPTAERLLTHtfvaqpgLSRALAV----ELLD--------KVNNPDNHAHYTEA 306
Cdd:cd05100 257 KPANCTH---ELYMIMRECWHAVPSQRPTFKQLVED-------LDRVLTVtstdEYLDlsvpfeqySPGCPDSPSSCSSG 326

                ....*
gi 38570135 307 DDDDF 311
Cdd:cd05100 327 DDSVF 331
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
20-322 2.19e-14

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 75.48  E-value: 2.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAyfgsylsrekLWICMEYC 97
Cdd:cd07858   7 YVPIKPIGRGAYGIVCSAKNSETNEKVAIKKIAnaFDNRIDAKRTLREIKLLRHLDHENVIA----------IKDIMPPP 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHV--------------TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd07858  77 HREAFNDVYIVyelmdtdlhqiirsSQTLSDDHCQYFLYQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP--PMFD-LHPMRAL--FLMSKSN---- 234
Cdd:cd07858 157 TTSEKGDFMTEYVVTRWYRAPELLLNCSE--YTTAIDVWSVGCIFAELLGRKPlfPGKDyVHQLKLIteLLGSPSEedlg 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 235 -FQPPKLKdktKWSSTFHNFVKIALTKN-PKKRPTAERLLTHTFVAQPglSRALAVEllDKVNNPDNHAHYTEADDD--- 309
Cdd:cd07858 235 fIRNEKAR---RYIRSLPYTPRQSFARLfPHANPLAIDLLEKMLVFDP--SKRITVE--EALAHPYLASLHDPSDEPvcq 307
                       330
                ....*....|....*...
gi 38570135 310 -----DFEPHAIIRHTIR 322
Cdd:cd07858 308 tpfsfDFEEDALTEEDIK 325
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
26-272 2.20e-14

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 74.66  E-value: 2.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGE-------LAAVKIIKLEPGD-DFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd05098  21 LGEGCFGQVVLAEAIGLDKdkpnrvtKVAVKMLKSDATEkDLSDLISEMEMMKMIgKHKNIINLLGACTQDGPLYVIVEY 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGP----------------LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG 160
Cdd:cd05098 101 ASKGNLREYLQARRPpgmeycynpshnpeeqLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 161 VAAKITATIAKRKSFIGT-PY-WMAPEvAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFqpp 238
Cdd:cd05098 181 LARDIHHIDYYKKTTNGRlPVkWMAPE-ALFDRI--YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH--- 254
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 239 KLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd05098 255 RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 288
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
26-274 2.30e-14

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 73.84  E-value: 2.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDfslIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQ 103
Cdd:cd14115   1 IGRGRFSIVKKCLHKATRKDVAVKFVskKMKKKEQ---AAHEAALLQHLQHPQYITLHDTYESPTSYILVLELMDDGRLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---DHGDVKLADFGVAAKITATIaKRKSFIGTPY 180
Cdd:cd14115  78 DYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDlriPVPRVKLIDLEDAVQISGHR-HVHHLLGNPE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 WMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ-PPKLKDKTkwSSTFHNFVKIALT 259
Cdd:cd14115 157 FAAPEVI---QGTPVSLATDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSfPDEYFGDV--SQAARDFINVILQ 231
                       250
                ....*....|....*
gi 38570135 260 KNPKKRPTAERLLTH 274
Cdd:cd14115 232 EDPRRRPTAATCLQH 246
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
26-206 2.74e-14

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 73.50  E-value: 2.74e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKArNVHTGELAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS-LQ 103
Cdd:cd05085   4 LGKGNFGEVYKG-TLKDKTPVAVKTCKEDLPQELKIkFLSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGDfLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY-WM 182
Cdd:cd05085  83 FLRKKKDELKTKQLVKFSLDAAAGMAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQIPIkWT 162
                       170       180
                ....*....|....*....|....
gi 38570135 183 APEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd05085 163 APEAL---NYGRYSSESDVWSFGI 183
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
16-271 3.48e-14

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 73.95  E-value: 3.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGELAavkIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFgSYLSREKLWICM 94
Cdd:cd05071   7 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVA---IKTLKPGTmSPEAFLQEAQVMKKLRHEKLVQLY-AVVSEEPIYIVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYH-VTGPLSEL-QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd05071  83 EYMSKGSLLDFLKgEMGKYLRLpQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 173 KSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKlkdKTKWSSTFH 251
Cdd:cd05071 163 RQGAKFPIkWTAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC---PPECPESLH 236
                       250       260
                ....*....|....*....|
gi 38570135 252 NFVKIALTKNPKKRPTAERL 271
Cdd:cd05071 237 DLMCQCWRKEPEERPTFEYL 256
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
27-268 3.66e-14

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 73.06  E-value: 3.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKArnVHTGELAAVKIIKLEPgdDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLwiCMEYCGGGSLQDIY 106
Cdd:cd14068   3 GDGGFGSVYRA--VYRGEDVAVKIFNKHT--SFRLLRQELVVLSHLHHPSLVALLAAGTAPRML--VMELAPKGSLDALL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 107 -HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL----TDHGDV-KLADFGVAAKITATiaKRKSFIGTPY 180
Cdd:cd14068  77 qQDNASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLftlyPNCAIIaKIADYGIAQYCCRM--GIKTSEGTPG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 WMAPEVAavEKNGGYNQLCDIWAVGITAIEL---------GELQPPMFDLHPMRAlflmsksnfqppKLKDKTK------ 245
Cdd:cd14068 155 FRAPEVA--RGNVIYNQQADVYSFGLLLYDIltcgeriveGLKFPNEFDELAIQG------------KLPDPVKeygcap 220
                       250       260
                ....*....|....*....|...
gi 38570135 246 WSStFHNFVKIALTKNPKKRPTA 268
Cdd:cd14068 221 WPG-VEALIKDCLKENPQCRPTS 242
PKc_CLK cd14134
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity ...
20-276 4.02e-14

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on S/T residues. In Drosophila, the CLK homolog DOA (Darkener of apricot) is essential for embryogenesis and its mutation leads to defects in sexual differentiation, eye formation, and neuronal development. In fission yeast, the CLK homolog Lkh1 is a negative regulator of filamentous growth and asexual flocculation, and is also involved in oxidative stress response. Vertebrates contain mutliple CLK proteins and mammals have four (CLK1-4). The CLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271036 [Multi-domain]  Cd Length: 332  Bit Score: 74.52  E-value: 4.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMV-----KECKHcNIVAYFGSYLSREKLWIC 93
Cdd:cd14134  14 YKILRLLGEGTFGKVLECWDRKRKRYVAVKIIRNVEKyREAAKIEIDVLETlaekdPNGKS-HCVQLRDWFDYRGHMCIV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGgSLQDI-----YHVTgPLSelQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD------------------ 150
Cdd:cd14134  93 FELLGP-SLYDFlkknnYGPF-PLE--HVQHIAKQLLEAVAFLHDLKLTHTDLKPENILLVDsdyvkvynpkkkrqirvp 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 151 -HGDVKLADFGVAakiTATIAKRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL--GELqppMFDLHP-MRA 226
Cdd:cd14134 169 kSTDIKLIDFGSA---TFDDEYHSSIVSTRHYRAPEVIL---GLGWSYPCDVWSIGCILVELytGEL---LFQTHDnLEH 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 227 LFLMSKSNFQPPKL---------------KDKTKWS-----------------------STFH----NFVKIALTKNPKK 264
Cdd:cd14134 240 LAMMERILGPLPKRmirrakkgakyfyfyHGRLDWPegsssgrsikrvckplkrlmllvDPEHrllfDLIRKMLEYDPSK 319
                       330
                ....*....|..
gi 38570135 265 RPTAERLLTHTF 276
Cdd:cd14134 320 RITAKEALKHPF 331
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
21-237 4.43e-14

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 73.50  E-value: 4.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDVYKARnvHTGELAaVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd14153   3 EIGELIGKGRFGQVYHGR--WHGEVA-IRLIDIERDNEEQLkaFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSL----QDIYHVTGPLSELQIAyvcRETLQGLAYLHTKGKMHRDIKGANILLtDHGDVKLADFGVAAkITATI--AKR 172
Cdd:cd14153  80 GRTLysvvRDAKVVLDVNKTRQIA---QEIVKGMGYLHAKGILHKDLKSKNVFY-DNGKVVITDFGLFT-ISGVLqaGRR 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 173 KSFIGTPY-W---MAPEV------AAVEKNGGYNQLCDIWAVGITAIELGELQPPmFDLHPMRALFLMSKSNFQP 237
Cdd:cd14153 155 EDKLRIQSgWlchLAPEIirqlspETEEDKLPFSKHSDVFAFGTIWYELHAREWP-FKTQPAEAIIWQVGSGMKP 228
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
18-272 4.81e-14

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 72.99  E-value: 4.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVY--KARNVHTgelAAVKIIKLEPGDDFSLIQQEIFMVKeCKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05113   4 KDLTFLKELGTGQFGVVKygKWRGQYD---VAIKMIKEGSMSEDEFIEEAKVMMN-LSHEKLVQLYGVCTKQRPIFIITE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKS 174
Cdd:cd05113  80 YMANGCLLNYLREMRKrFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPY---WMAPEVAAVEKnggYNQLCDIWAVGITAIE---LGELQPPMFDlHPMRALFLMSKSNFQPPKLKDKTKWS- 247
Cdd:cd05113 158 SVGSKFpvrWSPPEVLMYSK---FSSKSDVWAFGVLMWEvysLGKMPYERFT-NSETVEHVSQGLRLYRPHLASEKVYTi 233
                       250       260
                ....*....|....*....|....*..
gi 38570135 248 --STFHnfvkialtKNPKKRPTAERLL 272
Cdd:cd05113 234 mySCWH--------EKADERPTFKILL 252
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
18-271 4.95e-14

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 72.98  E-value: 4.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFSLiqQEIFMVKECKHCNIVAYFGSYLsREKLWICMEYC 97
Cdd:cd05083   6 QKLTLGEIIGEGEFGAVLQGE--YMGQKVAVKNIKCDVTAQAFL--EETAVMTKLQHKNLVRLLGVIL-HNGLYIVMELM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF 175
Cdd:cd05083  81 SKGNLVNFLRSRGraLVPVIQLLQFSLDVAEGMEYLESKKLVHRDLAARNILVSEDGVAKISDFGLAKVGSMGVDNSRLP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 176 IGtpyWMAPEVAaveKNGGYNQLCDIWAVGITAIELGEL--QPpmfdlHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Cdd:cd05083 161 VK---WTAPEAL---KNKKFSSKSDVWSYGVLLWEVFSYgrAP-----YPKMSVKEVKEAVEKGYRMEPPEGCPPDVYSI 229
                       250
                ....*....|....*...
gi 38570135 254 VKIALTKNPKKRPTAERL 271
Cdd:cd05083 230 MTSCWEAEPGKRPSFKKL 247
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
18-265 5.18e-14

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 73.81  E-value: 5.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS-----LIQQEIFMVkeCKHCNIVAYFGSYLSREKLWI 92
Cdd:cd05574   1 DHFKKIKLLGKGDVGRVYLVRLKGTGKLFAMKVLDKEEMIKRNkvkrvLTEREILAT--LDHPFLPTLYASFQTSTHLCF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGslqDIYHV-----TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA----- 162
Cdd:cd05574  79 VMDYCPGG---ELFRLlqkqpGKRLPEEVARFYAAEVLLALEYLHLLGFVYRDLKPENILLHESGHIMLTDFDLSkqssv 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 ------------------------AKITATIAKRKSFIGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPm 218
Cdd:cd05574 156 tpppvrkslrkgsrrssvksiekeTFVAEPSARSNSFVGTEEYIAPEVI---KGDGHGSAVDWWTLGILLYEMLYGTTP- 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 219 FDLHPMRALFlmskSNF--QPPKLKDKTKWSSTFHNFVKIALTKNPKKR 265
Cdd:cd05574 232 FKGSNRDETF----SNIlkKELTFPESPPVSSEAKDLIRKLLVKDPSKR 276
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
25-216 5.33e-14

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 73.94  E-value: 5.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEpGDDFSLIQ-QEIFMVKECKHCNIVAYFGSYLSR--EKLWICMEYcgggS 101
Cdd:cd07868  24 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE-GTGISMSAcREIALLRELKHPNVISLQKVFLSHadRKVWLLFDY----A 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVTG------------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT----DHGDVKLADFGVAAKI 165
Cdd:cd07868  99 EHDLWHIIKfhraskankkpvQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMgegpERGRVKIADMGFARLF 178
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 38570135 166 TA---TIAKRKSFIGTPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQP 216
Cdd:cd07868 179 NSplkPLADLDPVVVTFWYRAPELLLGARH--YTKAIDIWAIGCIFAELLTSEP 230
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
20-274 5.36e-14

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 72.63  E-value: 5.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSlIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd14108   4 YDIHKEIGRGAFSYLRRVKEKSSDLSFAAKFIPVRAKKKTS-ARRELALLAELDHKSIVRFHDAFEKRRVVIIVTELCHE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVTgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD--VKLADFGVAAKITATIAKRKSFiG 177
Cdd:cd14108  83 ELLERITKRP-TVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKPENLLMADQKTdqVRICDFGNAQELTPNEPQYCKY-G 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSN--FQPPKLKDKTKWSSTFhnFVK 255
Cdd:cd14108 161 TPEFVAPEIV---NQSPVSKVTDIWPVGVIAYLCLTGISPFVGENDRTTLMNIRNYNvaFEESMFKDLCREAKGF--IIK 235
                       250
                ....*....|....*....
gi 38570135 256 IALtkNPKKRPTAERLLTH 274
Cdd:cd14108 236 VLV--SDRLRPDAEETLEH 252
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
20-179 5.56e-14

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 72.88  E-value: 5.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAvkiIKLEPGDDF-SLIQQEIFMVKECKHCNIVA---YFGSYlsREKLWICME 95
Cdd:cd14016   2 YKLVKKIGSGSFGEVYLGIDLKTGEEVA---IKIEKKDSKhPQLEYEAKVYKLLQGGPGIPrlyWFGQE--GDYNVMVMD 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCgGGSLQDIYHVTGP-LSE---LQIAYvcrETLQGLAYLHTKGKMHRDIKGANILL---TDHGDVKLADFGVAAKITAT 168
Cdd:cd14016  77 LL-GPSLEDLFNKCGRkFSLktvLMLAD---QMISRLEYLHSKGYIHRDIKPENFLMglgKNSNKVYLIDFGLAKKYRDP 152
                       170
                ....*....|....*...
gi 38570135 169 IAKR-------KSFIGTP 179
Cdd:cd14016 153 RTGKhipyregKSLTGTA 170
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
22-206 9.16e-14

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 72.29  E-value: 9.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKARNVHTGELAaVKIIKLEPGDDFSLIQQEIFMVKeCKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05112   8 FVQEIGSGQFGLVHLGYWLNKDKVA-IKTIREGAMSEEDFIEEAEVMMK-LSHPKLVQLYGVCLEQAPICLVFEFMEHGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDIYHVT-GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKSFIGTPY 180
Cdd:cd05112  86 LSDYLRTQrGLFSAETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVVKVSDFGMTRFVLDD--QYTSSTGTKF 163
                       170       180
                ....*....|....*....|....*....
gi 38570135 181 ---WMAPEVAaveKNGGYNQLCDIWAVGI 206
Cdd:cd05112 164 pvkWSSPEVF---SFSRYSSKSDVWSFGV 189
STKc_MRCK_alpha cd05623
Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 ...
17-238 9.43e-14

Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270773 [Multi-domain]  Cd Length: 409  Bit Score: 74.28  E-value: 9.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVK-ECKHCNIVAYfgSYLSREKLW 91
Cdd:cd05623  71 KEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNkwemLKRAETACFREERDVLVNgDSQWITTLHY--AFQDDNNLY 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIY-HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Cdd:cd05623 149 LVMDYYVGGDLLTLLsKFEDRLPEDMARFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGT 228
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 171 KRKSF-IGTPYWMAPEV--AAVEKNGGYNQLCDIWAVGITAIELGELQPPMF--DLHPMRALFLMSKSNFQPP 238
Cdd:cd05623 229 VQSSVaVGTPDYISPEIlqAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYaeSLVETYGKIMNHKERFQFP 301
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
24-271 1.11e-13

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 71.87  E-value: 1.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARNVHTGELAavkIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFgSYLSREKLWICMEYCGGGSL 102
Cdd:cd14203   1 VKLGQGCFGEVWMGTWNGTTKVA---IKTLKPGTmSPEAFLEEAQIMKKLRHDKLVQLY-AVVSEEPIYIVTEFMSKGSL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QD-IYHVTGPLSEL-QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY 180
Cdd:cd14203  77 LDfLKDGEGKYLKLpQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPI 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 181 -WMAPEVAAVeknGGYNQLCDIWAVGITAIEL---GELQPPMFD----LHPMRALFLMSKSNFQPPKLkdktkwsstfHN 252
Cdd:cd14203 157 kWTAPEAALY---GRFTIKSDVWSFGILLTELvtkGRVPYPGMNnrevLEQVERGYRMPCPPGCPESL----------HE 223
                       250
                ....*....|....*....
gi 38570135 253 FVKIALTKNPKKRPTAERL 271
Cdd:cd14203 224 LMCQCWRKDPEERPTFEYL 242
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
21-206 1.16e-13

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 71.75  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  21 ELVQRVGSGTYGDVYKARNVHTGELAAVKiiKLEPGDD--FSLIQQEIFMVKEC-KHCNIVAYFGSYlsreklwICMEYC 97
Cdd:cd13975   3 KLGRELGRGQYGVVYACDSWGGHFPCALK--SVVPPDDkhWNDLALEFHYTRSLpKHERIVSLHGSV-------IDYSYG 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSL----------QDIYH-VTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKIT 166
Cdd:cd13975  74 GGSSIavllimerlhRDLYTgIKAGLSLEERLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGF-CKPE 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAkrKSFIGTPYWMAPEVAavekNGGYNQLCDIWAVGI 206
Cdd:cd13975 153 AMMS--GSIVGTPIHMAPELF----SGKYDNSVDVYAFGI 186
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
16-216 1.49e-13

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 72.17  E-value: 1.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKAR--NVHTGE---LAAVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLSREK 89
Cdd:cd05050   3 PRNNIEYVRDIGQGAFGRVFQARapGLLPYEpftMVAVKMLKEEASADMQAdFQREAALMAEFDHPNIVKLLGVCAVGKP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGP----------------------LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL 147
Cdd:cd05050  83 MCLLFEYMAYGDLNEFLRHRSPraqcslshstssarkcglnplpLSCTEQLCIAKQVAAGMAYLSERKFVHRDLATRNCL 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38570135 148 LTDHGDVKLADFGVAAKITAT---IAKRKSFIGTpYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGE--LQP 216
Cdd:cd05050 163 VGENMVVKIADFGLSRNIYSAdyyKASENDAIPI-RWMPPESIFYNR---YTTESDVWAYGVVLWEIFSygMQP 232
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
27-274 1.50e-13

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 71.39  E-value: 1.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYGDVYKARNVHTG-ELAAvkiiKLEPGDDFSLiqQEIFMVKECKHCNIVAYFGSYLSREK---LWICMEYCGGGSL 102
Cdd:cd14109  13 KRAAQGAPFHVTERSTGrNFLA----QLRYGDPFLM--REVDIHNSLDHPNIVQMHDAYDDEKLavtVIDNLASTIELVR 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 103 QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHgDVKLADFGVA-----AKITATIakrksfIG 177
Cdd:cd14109  87 DNLLPGKDYYTERQVAVFVRQLLLALKHMHDLGIAHLDLRPEDILLQDD-KLKLADFGQSrrllrGKLTTLI------YG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 178 TPYWMAPEVAAVEkngGYNQLCDIWAVG-ITAIELGELQPPMFD-----LHPMRAlflmSKSNFqppklkDKTKW---SS 248
Cdd:cd14109 160 SPEFVSPEIVNSY---PVTLATDMWSVGvLTYVLLGGISPFLGDndretLTNVRS----GKWSF------DSSPLgniSD 226
                       250       260
                ....*....|....*....|....*.
gi 38570135 249 TFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14109 227 DARDFIKKLLVYIPESRLTVDEALNH 252
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
16-272 1.67e-13

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 72.36  E-value: 1.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGE-------LAAVKIIKLEPGD-DFSLIQQEIFMVKEC-KHCNIVAYFGSYLS 86
Cdd:cd05101  22 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKdkpkeavTVAVKMLKDDATEkDLSDLVSEMEMMKMIgKHKNIINLLGACTQ 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLWICMEYCGGGSLQDIYHVTGPLS---ELQIAYVCRETL-------------QGLAYLHTKGKMHRDIKGANILLTD 150
Cdd:cd05101 102 DGPLYVIVEYASKGNLREYLRARRPPGmeySYDINRVPEEQMtfkdlvsctyqlaRGMEYLASQKCIHRDLAARNVLVTE 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 151 HGDVKLADFGVAAKITATIAKRKSFIGT-PY-WMAPEvAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Cdd:cd05101 182 NNVMKIADFGLARDINNIDYYKKTTNGRlPVkWMAPE-ALFDRV--YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 258
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 38570135 229 LMSKSNFQPPKLKDKTkwsSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd05101 259 KLLKEGHRMDKPANCT---NELYMMMRDCWHAVPSQRPTFKQLV 299
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
16-294 2.05e-13

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 71.92  E-value: 2.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKAR-------NVHTGELAAVKIIKLEPGD-DFSLIQQEIFMVKEC-KHCNIVAYFGSYLS 86
Cdd:cd05099  10 PRDRLVLGKPLGEGCFGQVVRAEaygidksRPDQTVTVAVKMLKDNATDkDLADLISEMELMKLIgKHKNIINLLGVCTQ 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLWICMEYCGGGSLQDIYHVTGP-----------LSELQIAY-----VCRETLQGLAYLHTKGKMHRDIKGANILLTD 150
Cdd:cd05099  90 EGPLYVIVEYAAKGNLREFLRARRPpgpdytfditkVPEEQLSFkdlvsCAYQVARGMEYLESRRCIHRDLAARNVLVTE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 151 HGDVKLADFGVAAKITATIAKRKSFIG-TPY-WMAPEvAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Cdd:cd05099 170 DNVMKIADFGLARGVHDIDYYKKTSNGrLPVkWMAPE-ALFDRV--YTHQSDVWSFGILMWEIFTLGGSPYPGIPVEELF 246
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 229 LMSKSNFqppKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLlthtfvaqpglsralaVELLDKV 294
Cdd:cd05099 247 KLLREGH---RMDKPSNCTHELYMLMRECWHAVPTQRPTFKQL----------------VEALDKV 293
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
24-186 2.93e-13

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 71.24  E-value: 2.93e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDFsLIQQEIFMVKECKHCNIVAYFGS------YLSREKLwICMEYC 97
Cdd:cd14054   1 QLIGQGRYGTVWKGS--LDERPVAVKVFPARHRQNF-QNEKDIYELPLMEHSNILRFIGAderptaDGRMEYL-LVLEYA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDiYHVTGPLSELQIAYVCRETLQGLAYLHTKGKM---------HRDIKGANILLTDHGDVKLADFGVAAKI--- 165
Cdd:cd14054  77 PKGSLCS-YLRENTLDWMSSCRMALSLTRGLAYLHTDLRRgdqykpaiaHRDLNSRNVLVKADGSCVICDFGLAMVLrgs 155
                       170       180       190
                ....*....|....*....|....*....|..
gi 38570135 166 -----------TATIAKRksfiGTPYWMAPEV 186
Cdd:cd14054 156 slvrgrpgaaeNASISEV----GTLRYMAPEV 183
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
20-274 2.96e-13

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 71.45  E-value: 2.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG------DDFSLIQQeifmVKECK-----HCNIVAYFGSYLSR- 87
Cdd:cd14136  12 YHVVRKLGWGHFSTVWLCWDLQNKRFVALKVVKSAQHyteaalDEIKLLKC----VREADpkdpgREHVVQLLDDFKHTg 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 -EKLWICM--EYCGGGSLQDI--YHVTGplseLQIAYV---CRETLQGLAYLHTKGKM-HRDIKGANILLT-DHGDVKLA 157
Cdd:cd14136  88 pNGTHVCMvfEVLGPNLLKLIkrYNYRG----IPLPLVkkiARQVLQGLDYLHTKCGIiHTDIKPENVLLCiSKIEVKIA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 158 DFGVAA----KITATIAKRKsfigtpyWMAPEVAAvekNGGYNQLCDIWAVGITAIEL--GELqppMFDLHPMR------ 225
Cdd:cd14136 164 DLGNACwtdkHFTEDIQTRQ-------YRSPEVIL---GAGYGTPADIWSTACMAFELatGDY---LFDPHSGEdysrde 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 226 ---ALF---------------------------LMSKSNFQPPKLKD----KTKWS----STFHNFVKIALTKNPKKRPT 267
Cdd:cd14136 231 dhlALIiellgriprsiilsgkysreffnrkgeLRHISKLKPWPLEDvlveKYKWSkeeaKEFASFLLPMLEYDPEKRAT 310

                ....*..
gi 38570135 268 AERLLTH 274
Cdd:cd14136 311 AAQCLQH 317
PTKc_Wee1a cd14138
Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the ...
19-275 3.79e-13

Catalytic domain of the Protein Tyrosine Kinase, Wee1a; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of human Wee1a, Xenopus laevis Wee1b (XeWee1b) and similar vertebrate proteins. Members of this subfamily show a wide expression pattern. XeWee1b functions after the first zygotic cell divisions. It is expressed in all tissues and is also present after the gastrulation stage of embryos. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The Wee1a subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271040 [Multi-domain]  Cd Length: 276  Bit Score: 70.82  E-value: 3.79e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKEC-KHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14138   6 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKkpLAGSVDEQNALREVYAHAVLgQHSHVVRYYSAWAEDDHMLIQNE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDI----YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---------DHGD--------- 153
Cdd:cd14138  86 YCNGGSLADAisenYRIMSYFTEPELKDLLLQVARGLKYIHSMSLVHMDIKPSNIFISrtsipnaasEEGDedewasnkv 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 154 -VKLADFGVAAKITATIAKRksfiGTPYWMAPEVaaVEKNGGYNQLCDIWAVGITAIELGELQP-PMF--DLHPMRALFL 229
Cdd:cd14138 166 iFKIGDLGHVTRVSSPQVEE----GDSRFLANEV--LQENYTHLPKADIFALALTVVCAAGAEPlPTNgdQWHEIRQGKL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 230 msksnfqpPKLKDKTkwSSTFHNFVKIALTKNPKKRPTAERLLTHT 275
Cdd:cd14138 240 --------PRIPQVL--SQEFLDLLKVMIHPDPERRPSAVALVKHS 275
PTKc_Wee1 cd14051
Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the ...
23-275 5.24e-13

Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Wee1 is a nuclear cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. There are two distinct Wee1 proteins in vertebrates showing different expression patterns, called Wee1a and Wee1b. They are functionally dstinct and are implicated in different steps of egg maturation and embryo development. The Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270953 [Multi-domain]  Cd Length: 275  Bit Score: 70.13  E-value: 5.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKlEPgddFSLIQQEIFMVKEC-------KHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14051   5 VEKIGSGEFGSVYKCINRLDGCVYAIKKSK-KP---VAGSVDEQNALNEVyahavlgKHPHVVRYYSAWAEDDHMIIQNE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDI----YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT---------------------- 149
Cdd:cd14051  81 YCNGGSLADAisenEKAGERFSEAELKDLLLQVAQGLKYIHSQNLVHMDIKPGNIFISrtpnpvsseeeeedfegeednp 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 150 --DHGDVKLADFGVAAKITatiaKRKSFIGTPYWMAPEVaaVEKNggYNQL--CDIWAVGITAIEL---GELQPPMFDLH 222
Cdd:cd14051 161 esNEVTYKIGDLGHVTSIS----NPQVEEGDCRFLANEI--LQEN--YSHLpkADIFALALTVYEAaggGPLPKNGDEWH 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 38570135 223 PMRalflmsKSNFQP-PKLkdktkwSSTFHNFVKIALTKNPKKRPTAERLLTHT 275
Cdd:cd14051 233 EIR------QGNLPPlPQC------SPEFNELLRSMIHPDPEKRPSAAALLQHP 274
PKc_YAK1 cd14212
Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze ...
20-211 5.74e-13

Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of proteins with similarity to Saccharomyces cerevisiae YAK1 (or Yak1p), a dual-specificity kinase that autophosphorylates at tyrosine residues and phosphorylates substrates on S/T residues. YAK1 phosphorylates and activates the transcription factors Hsf1 and Msn2, which play important roles in cellular homeostasis during stress conditions including heat shock, oxidative stress, and nutrient deficiency. It also phosphorylates the protein POP2, a component of a complex that regulates transcription, under glucose-deprived conditions. It functions as a part of a glucose-sensing system that is involved in controlling growth in yeast. The YAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271114 [Multi-domain]  Cd Length: 330  Bit Score: 70.74  E-value: 5.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgddfSLIQQ---EIFMV--------KECKHcNIVAYFGSYLSRE 88
Cdd:cd14212   1 YLVLDLLGQGTFGQVVKCQDLKTNKLVAVKVLKNKP----AYFRQamlEIAILtllntkydPEDKH-HIVRLLDHFMHHG 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCG-------------GGSLQDIYHVTGPLselqiayvcretLQGLAYLHTKGKMHRDIKGANILLT--DHGD 153
Cdd:cd14212  76 HLCIVFELLGvnlyellkqnqfrGLSLQLIRKFLQQL------------LDALSVLKDARIIHCDLKPENILLVnlDSPE 143
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 38570135 154 VKLADFGVAAKITATIakrKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14212 144 IKLIDFGSACFENYTL---YTYIQSRFYRSPEVLL---GLPYSTAIDMWSLGCIAAEL 195
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
16-267 5.96e-13

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 70.59  E-value: 5.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARN---VHTGELAAVKIIKLEPGDDFS----LIQQEIFMVKECKHCNIVAYFGSYLSRE 88
Cdd:cd05055  33 PRNNLSFGKTLGAGAFGKVVEATAyglSKSDAVMKVAVKMLKPTAHSSereaLMSELKIMSHLGNHENIVNLLGACTIGG 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQDIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI- 165
Cdd:cd05055 113 PILVITEYCCYGDLLNFLRRKREsfLTLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICDFGLARDIm 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 --TATIAKRKSFIGTPyWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFL--------MSKSNF 235
Cdd:cd05055 193 ndSNYVVKGNARLPVK-WMAPESIF---NCVYTFESDVWSYGILLWEIFSLGSNPYPGMPVDSKFYklikegyrMAQPEH 268
                       250       260       270
                ....*....|....*....|....*....|....
gi 38570135 236 QPPKLKD--KTKWSSTfhnfvkialtknPKKRPT 267
Cdd:cd05055 269 APAEIYDimKTCWDAD------------PLKRPT 290
STKc_TTBK cd14017
Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the ...
20-211 6.25e-13

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270919 [Multi-domain]  Cd Length: 263  Bit Score: 69.59  E-value: 6.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKI-IKLEPGDDFSLIQQEIFMVKECKH-CNIVAyFGsylsREK--LWICME 95
Cdd:cd14017   2 WKVVKKIGGGGFGEIYKVRDVVDGEEVAMKVeSKSQPKQVLKMEVAVLKKLQGKPHfCRLIG-CG----RTEryNYIVMT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCgGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL----TDHGDVKLADFGVAAKITAT- 168
Cdd:cd14017  77 LL-GPNLAELRrsQPRGKFSVSTTLRLGIQILKAIEDIHEVGFLHRDVKPSNFAIgrgpSDERTVYILDFGLARQYTNKd 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 169 ----IAKRKS--FIGTPyWMAPEVAAVEKNGGYNQlcDIWAVGITAIEL 211
Cdd:cd14017 156 geveRPPRNAagFRGTV-RYASVNAHRNKEQGRRD--DLWSWFYMLIEF 201
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
25-210 7.30e-13

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 69.99  E-value: 7.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPG----DDFSLiqqEIFMVKECKHCNIVAYFGSYLSREKL------WICM 94
Cdd:cd14038   1 RLGTGGFGNVLRWINQETGEQVAIKQCRQELSpknrERWCL---EIQIMKRLNHPNVVAARDVPEGLQKLapndlpLLAM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQ---DIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLtDHGDVKLA----DFGVAAKITA 167
Cdd:cd14038  78 EYCQGGDLRkylNQFENCCGLREGAILTLLSDISSALRYLHENRIIHRDLKPENIVL-QQGEQRLIhkiiDLGYAKELDQ 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 168 TiAKRKSFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:cd14038 157 G-SLCTSFVGTLQYLAPELLEQQK---YTVTVDYWSFGTLAFE 195
STKc_DMPK_like cd05597
Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; ...
19-213 1.02e-12

Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is composed of DMPK and DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK). DMPK is expressed in skeletal and cardiac muscles, and in central nervous tissues. The functional role of DMPK is not fully understood. It may play a role in the signal transduction and homeostasis of calcium. The DMPK gene is implicated in myotonic dystrophy 1 (DM1), an inherited multisystemic disorder with symptoms that include muscle hyperexcitability, progressive muscle weakness and wasting, cataract development, testicular atrophy, and cardiac conduction defects. The genetic basis for DM1 is the mutational expansion of a CTG repeat in the 3'-UTR of DMPK. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270748 [Multi-domain]  Cd Length: 331  Bit Score: 70.07  E-value: 1.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIK----LEPGDDFSLIQQEIFMVKECKHCnIVAYFGSYLSREKLWICM 94
Cdd:cd05597   2 DFEILKVIGRGAFGEVAVVKLKSTEKVYAMKILNkwemLKRAETACFREERDVLVNGDRRW-ITKLHYAFQDENYLYLVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 E-YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA--TIAK 171
Cdd:cd05597  81 DyYCGGDLLTLLSKFEDRLPEEMARFYLAEMVLAIDSIHQLGYVHRDIKPDNVLLDRNGHIRLADFGSCLKLREdgTVQS 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 38570135 172 RKSfIGTPYWMAPEV--AAVEKNGGYNQLCDIWAVGITAIEL--GE 213
Cdd:cd05597 161 SVA-VGTPDYISPEIlqAMEDGKGRYGPECDWWSLGVCMYEMlyGE 205
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
24-223 1.09e-12

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 69.30  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARnvHTGELAAVKII-KLEPGDDFSliQQEIFMVKECKHCNIVAYFGSYL----SREKLWICMEYCG 98
Cdd:cd14220   1 RQIGKGRYGEVWMGK--WRGEKVAVKVFfTTEEASWFR--ETEIYQTVLMRHENILGFIAADIkgtgSWTQLYLITDYHE 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYHVT--GPLSELQIAYvcrETLQGLAYLHT-----KGK---MHRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd14220  77 NGSLYDFLKCTtlDTRALLKLAY---SAACGLCHLHTeiygtQGKpaiAHRDLKSKNILIKKNGTCCIADLGLAVKFNSD 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135 169 IAK----RKSFIGTPYWMAPEVAAVEKNGGYNQ---LCDIWAVGITAIELG----------ELQPPMFDLHP 223
Cdd:cd14220 154 TNEvdvpLNTRVGTKRYMAPEVLDESLNKNHFQayiMADIYSFGLIIWEMArrcvtggiveEYQLPYYDMVP 225
STKc_BMPR1b cd14219
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs ...
14-271 1.26e-12

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1b, also called Activin receptor-Like Kinase 6 (ALK6), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Mutations in BMPR1b that led to inhibition of chondrogenesis can cause Brachydactyly (BD) type A2, a dominant hand malformation characterized by shortening and lateral deviation of the index fingers. A point mutation in the BMPR1b kinase domain is also associated with the Booroola phenotype, characterized by precocious differentiation of ovarian follicles. BMPR1b belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1b, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271121 [Multi-domain]  Cd Length: 305  Bit Score: 69.69  E-value: 1.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  14 RNPQQDYELVQRVGSGTYGDVYKARnvHTGELAAVKII-KLEPGDDFSliQQEIFMVKECKHCNIVAYFGSYL----SRE 88
Cdd:cd14219   1 RTIAKQIQMVKQIGKGRYGEVWMGK--WRGEKVAVKVFfTTEEASWFR--ETEIYQTVLMRHENILGFIAADIkgtgSWT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQDIYHVT--GPLSELQIAYvcrETLQGLAYLHT-----KGK---MHRDIKGANILLTDHGDVKLAD 158
Cdd:cd14219  77 QLYLITDYHENGSLYDYLKSTtlDTKAMLKLAY---SSVSGLCHLHTeifstQGKpaiAHRDLKSKNILVKKNGTCCIAD 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 159 FGVAAKITATIAK----RKSFIGTPYWMAPEVAAVEKNGGYNQ---LCDIWAVGITAIELG----------ELQPPMFDL 221
Cdd:cd14219 154 LGLAVKFISDTNEvdipPNTRVGTKRYMPPEVLDESLNRNHFQsyiMADMYSFGLILWEVArrcvsggiveEYQLPYHDL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135 222 HP-------MRALFLMSKSNFQPPklkdkTKWSS-----TFHNFVKIALTKNPKKRPTAERL 271
Cdd:cd14219 234 VPsdpsyedMREIVCIKRLRPSFP-----NRWSSdeclrQMGKLMTECWAHNPASRLTALRV 290
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
20-268 1.44e-12

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 68.85  E-value: 1.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDfslIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYC 97
Cdd:cd14113   9 YSEVAELGRGRFSVVKKCDQRGTKRAVATKFVnkKLMKRDQ---VTHELGVLQSLQHPQLVGLLDTFETPTSYILVLEMA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD---VKLADFGVAAKITATIAKRKs 174
Cdd:cd14113  86 DQGRLLDYVVRWGNLTEEKIRFYLREILEALQYLHNCRIAHLDLKPENILVDQSLSkptIKLADFGDAVQLNTTYYIHQ- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPYWMAPEVAAveknGGYNQLC-DIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPklKDKTKW-SSTFHN 252
Cdd:cd14113 165 LLGSPEFAAPEIIL----GNPVSLTsDLWSIGVLTYVLLSGVSPFLDESVEETCLNICRLDFSFP--DDYFKGvSQKAKD 238
                       250
                ....*....|....*.
gi 38570135 253 FVKIALTKNPKKRPTA 268
Cdd:cd14113 239 FVCFLLQMDPAKRPSA 254
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
20-186 1.55e-12

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 68.35  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNV-HTGELAAVKIIKLEPGDDF--SLIQQEIFMVKECKHCNIVAYFGSY-LSREKLWICME 95
Cdd:cd14164   2 YTLGTTIGEGSFSKVKLATSQkYCCKVAIKIVDRRRASPDFvqKFLPRELSILRRVNHPNIVQMFECIeVANGRLYIVME 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIY---HVTGPLSELQIAYVcretLQGLAYLHTKGKMHRDIKGANILLT-DHGDVKLADFGVAAKITATIAK 171
Cdd:cd14164  82 AAATDLLQKIQevhHIPKDLARDMFAQM----VGAVNYLHDMNIVHRDLKCENILLSaDDRKIKIADFGFARFVEDYPEL 157
                       170
                ....*....|....*
gi 38570135 172 RKSFIGTPYWMAPEV 186
Cdd:cd14164 158 STTFCGSRAYTPPEV 172
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
18-211 1.97e-12

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 68.08  E-value: 1.97e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARnvHTGELAAVKIIKLEPGDDfSLIQQEIFMVkECKHCNIVAYFGSYLS-REKLWICMEY 96
Cdd:cd05082   6 KELKLLQTIGKGEFGDVMLGD--YRGNKVAVKCIKNDATAQ-AFLAEASVMT-QLRHSNLVQLLGVIVEeKGGLYIVTEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd05082  82 MAKGSLVDYLRSRGRsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL 161
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 38570135 175 FIGtpyWMAPEvAAVEKNggYNQLCDIWAVGITAIEL 211
Cdd:cd05082 162 PVK---WTAPE-ALREKK--FSTKSDVWSFGILLWEI 192
STKc_NDR_like_fungal cd05629
Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs ...
18-210 2.03e-12

Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group is composed of fungal NDR-like proteins including Saccharomyces cerevisiae CBK1 (or CBK1p), Schizosaccharomyces pombe Orb6 (or Orb6p), Ustilago maydis Ukc1 (or Ukc1p), and Neurospora crassa Cot1. Like NDR kinase, group members contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. CBK1 is an essential component in the RAM (regulation of Ace2p activity and cellular morphogenesis) network. CBK1 and Orb6 play similar roles in coordinating cell morphology with cell cycle progression. Ukc1 is involved in morphogenesis, pathogenicity, and pigment formation. Cot1 plays a role in polar tip extension.The fungal NDR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270778 [Multi-domain]  Cd Length: 377  Bit Score: 69.88  E-value: 2.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVK-IIKLE--PGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05629   1 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKtLLKSEmfKKDQLAHVKAERDVLAESDSPWVVSLYYSFQDAQYLYLIM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA----------- 163
Cdd:cd05629  81 EFLPGGDLMTMLIKYDTFSEDVTRFYMAECVLAIEAVHKLGFIHRDIKPDNILIDRGGHIKLSDFGLSTgfhkqhdsayy 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 ----------------------KITATIAKRK--------------SFIGTPYWMAPEVAAVEkngGYNQLCDIWAVGIT 207
Cdd:cd05629 161 qkllqgksnknridnrnsvavdSINLTMSSKDqiatwkknrrlmaySTVGTPDYIAPEIFLQQ---GYGQECDWWSLGAI 237

                ...
gi 38570135 208 AIE 210
Cdd:cd05629 238 MFE 240
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
22-211 2.22e-12

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 67.86  E-value: 2.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVY--KARNVHTgelAAVKIIKlePG----DDFslIQQEIFMVKeCKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05059   8 FLKELGSGQFGVVHlgKWRGKID---VAIKMIK--EGsmseDDF--IEEAKVMMK-LSHPKLVQLYGVCTKQRPIFIVTE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATiaKRKS 174
Cdd:cd05059  80 YMANGCLLNyLRERRGKFQTEQLLEMCKDVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDD--EYTS 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 175 FIGTPY---WMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05059 158 SVGTKFpvkWSPPEVFMYSK---FSSKSDVWSFGVLMWEV 194
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
110-223 3.58e-12

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 68.75  E-value: 3.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGvAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Cdd:PHA03209 152 RPLPIDQALIIEKQILEGLRYLHAQRIIHRDVKTENIFINDVDQVCIGDLG-AAQFPVVAPAFLGLAGTVETNAPEVLAR 230
                         90       100       110
                 ....*....|....*....|....*....|....
gi 38570135  190 EKnggYNQLCDIWAVGITAIELGELQPPMFDLHP 223
Cdd:PHA03209 231 DK---YNSKADIWSAGIVLFEMLAYPSTIFEDPP 261
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
29-211 3.63e-12

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 68.13  E-value: 3.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  29 GTYGDVYKARNVHtgELAAVKIIKLEPGDDFSlIQQEIFMVKECKHCNIVAYF-----GSYLSREkLWICMEYCGGGSLQ 103
Cdd:cd14140   6 GRFGCVWKAQLMN--EYVAVKIFPIQDKQSWQ-SEREIFSTPGMKHENLLQFIaaekrGSNLEME-LWLITAFHDKGSLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 104 DiYHVTGPLSELQIAYVCRETLQGLAYLH-----TKGK------MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Cdd:cd14140  82 D-YLKGNIVSWNELCHIAETMARGLSYLHedvprCKGEghkpaiAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKPPG 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 173 KSF--IGTPYWMAPEVAAVEKNGGYNQL--CDIWAVGITAIEL 211
Cdd:cd14140 161 DTHgqVGTRRYMAPEVLEGAINFQRDSFlrIDMYAMGLVLWEL 203
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
26-221 6.85e-12

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 67.45  E-value: 6.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQE--IFMVKEcKHCNIVAYFGSYLSREKLWICMEYCGGG 100
Cdd:cd05588   3 IGRGSYAKVLMVELKKTKRIYAMKVIKKElvnDDEDIDWVQTEkhVFETAS-NHPFLVGLHSCFQTESRLFFVIEFVNGG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLqdIYHVTGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV------AAKITATiakr 172
Cdd:cd05588  82 DL--MFHMQRQrrLPEEHARFYSAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMckeglrPGDTTST---- 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 173 ksFIGTPYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPmFDL 221
Cdd:cd05588 156 --FCGTPNYIAPEILRGED---YGFSVDWWALGVLMFEMLAGRSP-FDI 198
pknD PRK13184
serine/threonine-protein kinase PknD;
18-206 1.10e-11

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 68.64  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlEPGDDFSLIQQEifMVKECK------HCNIVAYFGSYLSREKLW 91
Cdd:PRK13184   2 QRYDIIRLIGKGGMGEVYLAYDPVCSRRVALKKIR-EDLSENPLLKKR--FLREAKiaadliHPGIVPVYSICSDGDPVY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   92 ICMEYCGGGSLQDIYH-------VTGPLSE-------LQIAY-VCretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKL 156
Cdd:PRK13184  79 YTMPYIEGYTLKSLLKsvwqkesLSKELAEktsvgafLSIFHkIC----ATIEYVHSKGVLHRDLKPDNILLGLFGEVVI 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38570135  157 ADFGVAAKITA--------TIAKRKSF----------IGTPYWMAPE----VAAVEKNggynqlcDIWAVGI 206
Cdd:PRK13184 155 LDWGAAIFKKLeeedlldiDVDERNICyssmtipgkiVGTPDYMAPErllgVPASEST-------DIYALGV 219
STKc_ACVR2a cd14141
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the ...
29-212 1.39e-11

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2a (or ActRIIA) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271043 [Multi-domain]  Cd Length: 290  Bit Score: 66.22  E-value: 1.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  29 GTYGDVYKARNVHtgELAAVKIIKLEpgDDFSLIQQ-EIFMVKECKHCNIVAYFGSylsrEK--------LWICMEYCGG 99
Cdd:cd14141   6 GRFGCVWKAQLLN--EYVAVKIFPIQ--DKLSWQNEyEIYSLPGMKHENILQFIGA----EKrgtnldvdLWLITAFHEK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDiYHVTGPLSELQIAYVCRETLQGLAYLHTK----------GKMHRDIKGANILLTDHGDVKLADFGVAAKITA-- 167
Cdd:cd14141  78 GSLTD-YLKANVVSWNELCHIAQTMARGLAYLHEDipglkdghkpAIAHRDIKSKNVLLKNNLTACIADFGLALKFEAgk 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 38570135 168 TIAKRKSFIGTPYWMAPEVAAVEKNGGYNQL--CDIWAVGITAIELG 212
Cdd:cd14141 157 SAGDTHGQVGTRRYMAPEVLEGAINFQRDAFlrIDMYAMGLVLWELA 203
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
16-206 1.70e-11

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 65.87  E-value: 1.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVH-TGELAAVKI-IKLEPGD-------DFSLiqqEIFMVKECKHCNIVAYFGSYLS 86
Cdd:cd05036   4 PRKNLTLIRALGQGAFGEVYEGTVSGmPGDPSPLQVaVKTLPELcseqdemDFLM---EALIMSKFNHPNIVRCIGVCFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLWICMEYCGGGSLQDIYHVTGPLSE----------LQIAyvcRETLQGLAYLHTKGKMHRDIKGANILLTDHGD--- 153
Cdd:cd05036  81 RLPRFILLELMAGGDLKSFLRENRPRPEqpssltmldlLQLA---QDVAKGCRYLEENHFIHRDIAARNCLLTCKGPgrv 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 154 VKLADFGVAAKITATIAKRKSfiGTPY----WMAPEvAAVEknGGYNQLCDIWAVGI 206
Cdd:cd05036 158 AKIGDFGMARDIYRADYYRKG--GKAMlpvkWMPPE-AFLD--GIFTSKTDVWSFGV 209
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
20-211 2.06e-11

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 66.59  E-value: 2.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII--KLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL------W 91
Cdd:cd07876  23 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLsrPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKSLeefqdvY 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHvtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAK 171
Cdd:cd07876 103 LVMELMDANLCQVIHM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTACTNFM 178
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL 211
Cdd:cd07876 179 MTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEL 215
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
16-216 2.19e-11

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 65.47  E-value: 2.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKARNVHTGE-----LAAVKIIK----LEPGDDFsliQQEIFMVKECKHCNIVAYFGSYLS 86
Cdd:cd05048   3 PLSAVRFLEELGEGAFGKVYKGELLGPSSeesaiSVAIKTLKenasPKTQQDF---RREAELMSDLQHPNIVCLLGVCTK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLwiCM--EYCGGGSLQ-------------------DIYHVTGPLSELQIAYvcrETLQGLAYLHTKGKMHRDIKGAN 145
Cdd:cd05048  80 EQPQ--CMlfEYMAHGDLHeflvrhsphsdvgvssdddGTASSLDQSDFLHIAI---QIAAGMEYLSSHHYVHRDLAARN 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 146 ILLTDHGDVKLADFGVAAKITATIAKR---KSFIgtPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIELGE--LQP 216
Cdd:cd05048 155 CLVGDGLTVKISDFGLSRDIYSSDYYRvqsKSLL--PVrWMPPEAILY---GKFTTESDVWSFGVVLWEIFSygLQP 226
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
104-210 2.30e-11

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 66.84  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  104 DIYHVTG----PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA--AKITATIAKRKSFIG 177
Cdd:PHA03211 245 DLYTYLGarlrPLGLAQVTAVARQLLSAIDYIHGEGIIHRDIKTENVLVNGPEDICLGDFGAAcfARGSWSTPFHYGIAG 324
                         90       100       110
                 ....*....|....*....|....*....|...
gi 38570135  178 TPYWMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:PHA03211 325 TVDTNAPEVLAGDP---YTPSVDIWSAGLVIFE 354
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
28-204 2.60e-11

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 64.83  E-value: 2.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  28 SGTYGDVYKARNVHTGeLAAVKIIKLEP---GDDFSLIQqEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD 104
Cdd:cd14027   3 SGGFGKVSLCFHRTQG-LVVLKTVYTGPnciEHNEALLE-EGKMMNRLRHSRVVKLLGVILEEGKYSLVMEYMEKGNLMH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 105 IYH-VTGPLSelQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-----AKITATIAKRKSFI-- 176
Cdd:cd14027  81 VLKkVSVPLS--VKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAsfkmwSKLTKEEHNEQREVdg 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 177 ------GTPYWMAPE------VAAVEKNGGYNQLCDIWAV 204
Cdd:cd14027 159 takknaGTLYYMAPEhlndvnAKPTEKSDVYSFAIVLWAI 198
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
26-272 6.78e-11

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 63.59  E-value: 6.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYK--ARNV---HTGEL-AAVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd05044   3 LGSGAFGEVFEgtAKDIlgdGSGETkVAVKTLRKGATDqEKAEFLKEAHLMSNFKHPNILKLLGVCLDNDPQYIILELME 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIYH------VTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKITA 167
Cdd:cd05044  83 GGDLLSYLRaarptaFTPPlLTLKDLLSICVDVAKGCVYLEDMHFVHRDLAARNCLVSSKDYrervVKIGDFGLARDIYK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGT-PY-WMAPEvAAVEknGGYNQLCDIWAVGITAIE---LGElQPpmfdlHPMRalflmskSNF------- 235
Cdd:cd05044 163 NDYYRKEGEGLlPVrWMAPE-SLVD--GVFTTQSDVWAFGVLMWEiltLGQ-QP-----YPAR-------NNLevlhfvr 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 236 ------QPPKLKDKtkwsstFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd05044 227 aggrldQPDNCPDD------LYELMLRCWSTDPEERPSFARIL 263
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
22-210 7.63e-11

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 63.55  E-value: 7.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKARNVHTGE---LAAVKIIKlePG------DDFsliQQEIFMVKECKHCNIVAYFGSYLSREKLWI 92
Cdd:cd05033   8 IEKVIGGGEFGEVCSGSLKLPGKkeiDVAIKTLK--SGysdkqrLDF---LTEASIMGQFDHPNVIRLEGVVTKSRPVMI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLqDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA-----AKI 165
Cdd:cd05033  83 VTEYMENGSL-DKFlrENDGKFTVTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSrrledSEA 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 38570135 166 TATIAKRKSFIgtpYWMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:cd05033 162 TYTTKGGKIPI---RWTAPEAIAYRK---FTSASDVWSFGIVMWE 200
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
20-206 8.96e-11

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 63.49  E-value: 8.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgdDFS---------LIQQEIFMVKECKHCNIVAYFGSY-LSREK 89
Cdd:cd13990   2 YLLLNLLGKGGFSEVYKAFDLVEQRYVACKIHQLNK--DWSeekkqnyikHALREYEIHKSLDHPRIVKLYDVFeIDTDS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILL---TDHGDVKLADFGVaAK 164
Cdd:cd13990  80 FCTVLEYCDGNDLDFYLKQHKSIPEREARSIIMQVVSALKYLNEIKPpiIHYDLKPGNILLhsgNVSGEIKITDFGL-SK 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 38570135 165 I-------TATIAKRKSFIGTPYWMAPEVAAVEKNG-GYNQLCDIWAVGI 206
Cdd:cd13990 159 ImddesynSDGMELTSQGAGTYWYLPPECFVVGKTPpKISSKVDVWSVGV 208
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
20-211 9.80e-11

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 64.34  E-value: 9.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL------W 91
Cdd:cd07874  19 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSrpFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKSLeefqdvY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHvtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAK 171
Cdd:cd07874  99 LVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFM 174
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 38570135 172 RKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL 211
Cdd:cd07874 175 MTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEM 211
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
20-278 1.65e-10

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 63.64  E-value: 1.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYF------GSYLSRE----- 88
Cdd:cd07854   7 YMDLRPLGCGSNGLVFSAVDSDCDKRVAVKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVYevlgpsGSDLTEDvgslt 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 ---KLWICMEYCGggslQDIYHV--TGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLADFGVa 162
Cdd:cd07854  87 elnSVYIVQEYME----TDLANVleQGPLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANVFInTEDLVLKIGDFGL- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKITATIAKRKSFIG----TPYWMAPEVAAVEKNggYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKS----- 233
Cdd:cd07854 162 ARIVDPHYSHKGYLSeglvTKWYRSPRLLLSPNN--YTKAIDMWAAGCIFAEMLTGKPLFAGAHELEQMQLILESvpvvr 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 234 --------NFQPPKLKDKTKW------------SSTFHNFVKIALTKNPKKRPTAERLLTHTFVA 278
Cdd:cd07854 240 eedrnellNVIPSFVRNDGGEprrplrdllpgvNPEALDFLEQILTFNPMDRLTAEEALMHPYMS 304
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
20-205 1.66e-10

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 63.59  E-value: 1.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKiiKL-EPgddFSLIQ------QEIFMVKECKHCNIVAYFGSYLSREKL-- 90
Cdd:cd07850   2 YQNLKPIGSGAQGIVCAAYDTVTGQNVAIK--KLsRP---FQNVThakrayRELVLMKLVNHKNIIGLLNVFTPQKSLee 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 ----WICMEYCGGgSLQDIYHVTgpLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKIT 166
Cdd:cd07850  77 fqdvYLVMELMDA-NLCQVIQMD--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTA 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 38570135 167 ATiakrkSFIGTP-----YWMAPEVAAvekNGGYNQLCDIWAVG 205
Cdd:cd07850 153 GT-----SFMMTPyvvtrYYRAPEVIL---GMGYKENVDIWSVG 188
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
18-224 2.16e-10

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 63.08  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   18 QDYELVQRVGSGTYGDV----YKARN---VHTGELAAVKIIKLEPGDDfslIQQEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:PTZ00426  30 EDFNFIRTLGTGSFGRVilatYKNEDfppVAIKRFEKSKIIKQKQVDH---VFSERKILNYINHPFCVNLYGSFKDESYL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   91 WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATia 170
Cdd:PTZ00426 107 YLVLEFVIGGEFFTFLRRNKRFPNDVGCFYAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGF-AKVVDT-- 183
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 38570135  171 KRKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIELGELQPPMFDLHPM 224
Cdd:PTZ00426 184 RTYTLCGTPEYIAPEILL---NVGHGKAADWWTLGIFIYEILVGCPPFYANEPL 234
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
122-220 2.38e-10

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 63.48  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  122 RETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA-KITATIAKRKSFIGTPYWMAPEVAAVEKnggYNQLCD 200
Cdd:PHA03212 189 RSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAACfPVDINANKYYGWAGTIATNAPELLARDP---YGPAVD 265
                         90       100
                 ....*....|....*....|
gi 38570135  201 IWAVGITAIELGELQPPMFD 220
Cdd:PHA03212 266 IWSAGIVLFEMATCHDSLFE 285
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
26-267 2.82e-10

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 62.29  E-value: 2.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGELA-----AVKIIKLEPGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05045   8 LGEGEFGKVVKATAFRLKGRAgyttvAVKMLKENASSsELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIYHVT------------------------GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVK 155
Cdd:cd05045  88 GSLRSFLRESrkvgpsylgsdgnrnssyldnpdeRALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMK 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 156 LADFGVAAKI---TATIAKRKSFIGTPyWMAPEVAAvekNGGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRaLFLMS 231
Cdd:cd05045 168 ISDFGLSRDVyeeDSYVKRSKGRIPVK-WMAIESLF---DHIYTTQSDVWSFGVLLWEIVTLgGNPYPGIAPER-LFNLL 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 38570135 232 KSNFqppKLKDKTKWSSTFHNFVKIALTKNPKKRPT 267
Cdd:cd05045 243 KTGY---RMERPENCSEEMYNLMLTCWKQEPDKRPT 275
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
26-211 2.86e-10

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 61.91  E-value: 2.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGEL-AAVKIIKLEPGddFSLIQQEIFM-----VKECKHCNIVAYFGSYLSREKLWICMEYCGG 99
Cdd:cd05063  13 IGAGEFGEVFRGILKMPGRKeVAVAIKTLKPG--YTEKQRQDFLseasiMGQFSHHNIIRLEGVVTKFKPAMIITEYMEN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSL-QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI------TATIAKR 172
Cdd:cd05063  91 GALdKYLRDHDGEFSSYQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVSDFGLSRVLeddpegTYTTSGG 170
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 38570135 173 KSFIgtpYWMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05063 171 KIPI---RWTAPEAIAYRK---FTSASDVWSFGIVMWEV 203
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
26-272 2.88e-10

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 62.10  E-value: 2.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVY--KARNVHTGELAAVKIIK-LEPGDDFSLIQ---QEIFMVKECKHCNIVAYFGsyLSREKLWICM--EYC 97
Cdd:cd05046  13 LGRGEFGEVFlaKAKGIEEEGGETLVLVKaLQKTKDENLQSefrRELDMFRKLSHKNVVRLLG--LCREAEPHYMilEYT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  98 GGGSLQDIYHVTG---------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA-KITA 167
Cdd:cd05046  91 DLGDLKQFLRATKskdeklkppPLSTKQKVALCTQIALGMDHLSNARFVHRDLAARNCLVSSQREVKVSLLSLSKdVYNS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIAKRKSFIGTPYWMAPEvaAVEKNgGYNQLCDIWAVGITAIEL---GELqpPMFDLHPMRALflmSKSNFQPPKLKDKT 244
Cdd:cd05046 171 EYYKLRNALIPLRWLAPE--AVQED-DFSTKSDVWSFGVLMWEVftqGEL--PFYGLSDEEVL---NRLQAGKLELPVPE 242
                       250       260
                ....*....|....*....|....*...
gi 38570135 245 KWSSTFHNFVKIALTKNPKKRPTAERLL 272
Cdd:cd05046 243 GCPSRLYKLMTRCWAVNPKDRPSFSELV 270
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
25-210 2.94e-10

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 61.60  E-value: 2.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  25 RVGSGTYGDV----YKARNVHTGELAaVKIIKLEpgddfSLIQQEIFMVKECK------HCNIVAYFGSYLSrEKLWICM 94
Cdd:cd05060   2 ELGHGNFGSVrkgvYLMKSGKEVEVA-VKTLKQE-----HEKAGKKEFLREASvmaqldHPCIVRLIGVCKG-EPLMLVM 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Cdd:cd05060  75 ELAPLGPLLKYLKKRREIPVSDLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGMSRALGAGSDYYRA 154
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 38570135 175 FIGTPY---WMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:cd05060 155 TTAGRWplkWYAPECINYGK---FSSKSDVWSYGVTLWE 190
PK_GC_unk cd14045
Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The ...
40-271 3.23e-10

Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270947 [Multi-domain]  Cd Length: 269  Bit Score: 61.80  E-value: 3.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  40 VHTGELAAVKIIKLEPgddFSL---IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYhvtgpLSE-- 114
Cdd:cd14045  27 IYDGRTVAIKKIAKKS---FTLskrIRKEVKQVRELDHPNLCKFIGGCIEVPNVAIITEYCPKGSLNDVL-----LNEdi 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 115 -LQIAY---VCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA----KITATIAKRKSFIGTPYwMAPEV 186
Cdd:cd14045  99 pLNWGFrfsFATDIARGMAYLHQHKIYHGRLKSSNCVIDDRWVCKIADYGLTTyrkeDGSENASGYQQRLMQVY-LPPEN 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 187 AAVeKNGGYNQLCDIWAVGITAIELGELQPPM-FDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKR 265
Cdd:cd14045 178 HSN-TDTEPTQATDVYSYAIILLEIATRNDPVpEDDYSLDEAWCPPLPELISGKTENSCPCPADYVELIRRCRKNNPAQR 256

                ....*.
gi 38570135 266 PTAERL 271
Cdd:cd14045 257 PTFEQI 262
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
16-216 3.37e-10

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 61.95  E-value: 3.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKAR----NVHTGELAAVKIIK-LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL 90
Cdd:cd05090   3 PLSAVRFMEELGECAFGKIYKGHlylpGMDHAQLVAIKTLKdYNNPQQWNEFQQEASLMTELHHPNIVCLLGVVTQEQPV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGGGSLQDIYHVTGPLSELQIA-----------------YVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD 153
Cdd:cd05090  83 CMLFEFMNQGDLHEFLIMRSPHSDVGCSsdedgtvkssldhgdflHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLH 162
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38570135 154 VKLADFGVAAKITAT---IAKRKSFIGTpYWMAPEVAAVeknGGYNQLCDIWAVGITAIELGE--LQP 216
Cdd:cd05090 163 VKISDLGLSREIYSSdyyRVQNKSLLPI-RWMPPEAIMY---GKFSSDSDIWSFGVVLWEIFSfgLQP 226
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
20-214 3.52e-10

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 62.75  E-value: 3.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL------W 91
Cdd:cd07875  26 YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSrpFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLeefqdvY 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHvtgPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVaAKITATIAK 171
Cdd:cd07875 106 IVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFM 181
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 38570135 172 RKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITaieLGEL 214
Cdd:cd07875 182 MTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCI---MGEM 218
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
22-216 3.75e-10

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 61.96  E-value: 3.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKARNVHTG---ELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHCNIVAYFGSYLSREKLWICME 95
Cdd:cd05091  10 FMEELGEDRFGKVYKGHLFGTApgeQTQAVAIKTLKDKAEGPLreeFRHEAMLRSRLQHPNIVCLLGVVTKEQPMSMIFS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDIYHVTGPLSEL----------------QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159
Cdd:cd05091  90 YCSHGDLHEFLVMRSPHSDVgstdddktvkstlepaDFLHIVTQIAAGMEYLSSHHVVHKDLATRNVLVFDKLNVKISDL 169
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38570135 160 GVAAKITAtiAKRKSFIGTPY----WMAPEVAAVeknGGYNQLCDIWAVGITAIELGE--LQP 216
Cdd:cd05091 170 GLFREVYA--ADYYKLMGNSLlpirWMSPEAIMY---GKFSIDSDIWSYGVVLWEVFSygLQP 227
PTKc_Wee1b cd14139
Catalytic domain of the Protein Tyrosine Kinase, Wee1b; PTKs catalyze the transfer of the ...
23-275 4.24e-10

Catalytic domain of the Protein Tyrosine Kinase, Wee1b; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of human Wee1b (also called Wee2), Xenopus laevis Wee1a (XeWee1a) and similar vertebrate proteins. XeWee1a accumulates after exiting the metaphase II stage in oocytes and in early mitotic cells. It functions during the first zygotic cell division and not during subsequent divisions. Mammalian Wee2/Wee1b is an oocyte-specific inhibitor of meiosis that functions downstream of cAMP. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The Wee1b subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271041 [Multi-domain]  Cd Length: 274  Bit Score: 61.48  E-value: 4.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIFMVKEC-------KHCNIVAYFGSYLSREKLWICME 95
Cdd:cd14139   5 LEKIGVGEFGSVYKCIKRLDGCVYAIKRSM----RPFAGSSNEQLALHEVyahavlgHHPHVVRYYSAWAEDDHMIIQNE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  96 YCGGGSLQDI---------YHVTGPLSE--LQIAyvcretlQGLAYLHTKGKMHRDIKGANILLTD---------HGDVK 155
Cdd:cd14139  81 YCNGGSLQDAisentksgnHFEEPELKDilLQVS-------MGLKYIHNSGLVHLDIKPSNIFICHkmqsssgvgEEVSN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 156 LADF----GVAAKI-----TATIAKRKSFIGTPYWMAPEVaaVEKNGGYNQLCDIWAVGIT-AIELGELQPPM--FDLHP 223
Cdd:cd14139 154 EEDEflsaNVVYKIgdlghVTSINKPQVEEGDSRFLANEI--LQEDYRHLPKADIFALGLTvALAAGAEPLPTngAAWHH 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 38570135 224 MRalflmsKSNFQP-PKlkdktKWSSTFHNFVKIALTKNPKKRPTAERLLTHT 275
Cdd:cd14139 232 IR------KGNFPDvPQ-----ELPESFSSLLKNMIQPDPEQRPSATALARHT 273
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
24-211 5.81e-10

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 60.82  E-value: 5.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKAR-NVHTGEL--AAVKIIKLEpgddfSLIQQEIFM--VKEC------KHCNIVAYFGSYLSrEKLWI 92
Cdd:cd05040   1 EKLGDGSFGVVRRGEwTTPSGKViqVAVKCLKSD-----VLSQPNAMDdfLKEVnamhslDHPNLIRLYGVVLS-SPLMM 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYCGGGSLQDIYHVTGPlsELQIAYVCRETLQ---GLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGV--AAKIT- 166
Cdd:cd05040  75 VTELAPLGSLLDRLRKDQG--HFLISTLCDYAVQianGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLmrALPQNe 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 167 ---ATIAKRKsfigTPY-WMAPEVAaveKNGGYNQLCDIWAVGITAIEL 211
Cdd:cd05040 153 dhyVMQEHRK----VPFaWCAPESL---KTRKFSHASDVWMFGVTLWEM 194
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
28-211 5.91e-10

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 61.03  E-value: 5.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   28 SGTYGDVYKARNVHTGELAAVKIIKLEpgdDFSLIQqeiFMVKECKHCN---IVAYFGSYLSREKLWIcMEYCGGGSLQD 104
Cdd:PHA03390  26 DGKFGKVSVLKHKPTQKLFVQKIIKAK---NFNAIE---PMVHQLMKDNpnfIKLYYSVTTLKGHVLI-MDYIKDGDLFD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  105 IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD-VKLADFGVaAKITATiakrKS-FIGTPYWM 182
Cdd:PHA03390  99 LLKKEGKLSEAEVKKIIRQLVEALNDLHKHNIIHNDIKLENVLYDRAKDrIYLCDYGL-CKIIGT----PScYDGTLDYF 173
                        170       180
                 ....*....|....*....|....*....
gi 38570135  183 APEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:PHA03390 174 SPEKIKGHN---YDVSFDWWAVGVLTYEL 199
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
26-214 6.17e-10

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 60.82  E-value: 6.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKARNVHTGEL--AAVKIIK-LEPGDDFSLIQQEI-FMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGS 101
Cdd:cd05047   3 IGEGNFGQVLKARIKKDGLRmdAAIKRMKeYASKDDHRDFAGELeVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQD---------------IYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI 165
Cdd:cd05047  83 LLDflrksrvletdpafaIANSTAStLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 166 TATIAKRKSFIGTpYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGEL 214
Cdd:cd05047 163 EVYVKKTMGRLPV-RWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSL 207
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
17-211 6.77e-10

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 61.14  E-value: 6.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVH-----TGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLW 91
Cdd:cd05092   4 RRDIVLKWELGEGAFGKVFLAECHNllpeqDKMLVAVKALKEATESARQDFQREAELLTVLQHQHIVRFYGVCTEGEPLI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGGGSLQDIYHVTGPLSEL---------------QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKL 156
Cdd:cd05092  84 MVFEYMRHGDLNRFLRSHGPDAKIldggegqapgqltlgQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGQGLVVKI 163
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 157 ADFGVAAKITATIAKRksfIG----TPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05092 164 GDFGMSRDIYSTDYYR---VGgrtmLPIrWMPPESILYRK---FTTESDIWSFGVVLWEI 217
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
29-267 6.89e-10

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 61.09  E-value: 6.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  29 GTYGDVYKARNVHTGELAAVKIIKLE--PGD-DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDI 105
Cdd:cd14026   8 GAFGTVSRARHADWRVTVAIKCLKLDspVGDsERNCLLKEAEILHKARFSYILPILGICNEPEFLGIVTEYMTNGSLNEL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 106 YH-------VTGPLsELQIAYvcrETLQGLAYLH--TKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFI 176
Cdd:cd14026  88 LHekdiypdVAWPL-RLRILY---EIALGVNYLHnmSPPLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSISQSRSSK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 177 -----GTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDL-HPMRALFLMSKS---NFQPPKLKDKTKWS 247
Cdd:cd14026 164 sapegGTIIYMPPEEYEPSQKRRASVKHDIYSYAIIMWEVLSRKIPFEEVtNPLQIMYSVSQGhrpDTGEDSLPVDIPHR 243
                       250       260
                ....*....|....*....|
gi 38570135 248 STFHNFVKIALTKNPKKRPT 267
Cdd:cd14026 244 ATLINLIESGWAQNPDERPS 263
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
27-232 7.67e-10

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 60.75  E-value: 7.67e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  27 GSGTYgdVYKARnvHTGELAAVKIIKLE--------PGDD-------------FSLIQQEIFMVKECKHCNIVAYFGsyL 85
Cdd:cd14067   5 GSGTV--IYRAR--YQGQPVAVKRFHIKkckkrtdgSADTmlkhlraadamknFSEFRQEASMLHSLQHPCIVYLIG--I 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLQDI---------YHVTGPLSELQIAYvcrETLQGLAYLHTKGKMHRDIKGANILL-----TDH 151
Cdd:cd14067  79 SIHPLCFALELAPLGSLNTVleenhkgssFMPLGHMLTFKIAY---QIAAGLAYLHKKNIIFCDLKSDNILVwsldvQEH 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 152 GDVKLADFGVAakitatiakRKSF-------IGTPYWMAPEvaaVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPM 224
Cdd:cd14067 156 INIKLSDYGIS---------RQSFhegalgvEGTPGYQAPE---IRPRIVYDEKVDMFSYGMVLYELLSGQRPSLGHHQL 223

                ....*...
gi 38570135 225 RALFLMSK 232
Cdd:cd14067 224 QIAKKLSK 231
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
9-211 1.04e-09

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 60.35  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135   9 ADILRrnpQQDYELVQRVGSGTYGDVYKARNVHTGEL----AAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGs 83
Cdd:cd05111   1 ARIFK---ETELRKLKVLGSGVFGTVHKGIWIPEGDSikipVAIKVIQDRSGrQSFQAVTDHMLAIGSLDHAYIVRLLG- 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  84 YLSREKLWICMEYCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162
Cdd:cd05111  77 ICPGASLQLVTQLLPLGSLLDhVRQHRGSLGPQLLLNWCVQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVA 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 38570135 163 AKITATIAKR-KSFIGTPY-WMAPEVAAVeknGGYNQLCDIWAVGITAIEL 211
Cdd:cd05111 157 DLLYPDDKKYfYSEAKTPIkWMALESIHF---GKYTHQSDVWSYGVTVWEM 204
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
20-277 1.16e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 59.98  E-value: 1.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF------SLIQQEIFMVKECKH--CNIVAYFGSYLSREKLW 91
Cdd:cd14100   2 YQVGPLLGSGGFGSVYSGIRVADGAPVAIKHVEKDRVSEWgelpngTRVPMEIVLLKKVGSgfRGVIRLLDWFERPDSFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYcgGGSLQDIYHVT---GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-DHGDVKLADFGVAAKITA 167
Cdd:cd14100  82 LVLER--PEPVQDLFDFIterGALPEELARSFFRQVLEAVRHCHNCGVLHRDIKDENILIDlNTGELKLIDFGSGALLKD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 168 TIakRKSFIGTPYWMAPEVAAVEKNGGYNqlCDIWAVGITAIEL--GELqPPMFDLHPMRALFLMsksnfqppklkdKTK 245
Cdd:cd14100 160 TV--YTDFDGTRVYSPPEWIRFHRYHGRS--AAVWSLGILLYDMvcGDI-PFEHDEEIIRGQVFF------------RQR 222
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14100 223 VSSECQHLIKWCLALRPSDRPSFEDIQNHPWM 254
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
16-211 1.18e-09

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 60.17  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVYKA--RNVHTGE---LAAVKIIKlEPGD-----DFsliQQEIFMVKECKHCNIVAYFGSYL 85
Cdd:cd05049   3 KRDTIVLKRELGEGAFGKVFLGecYNLEPEQdkmLVAVKTLK-DASSpdarkDF---EREAELLTNLQHENIVKFYGVCT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLQDIYHVTGP--------------LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH 151
Cdd:cd05049  79 EGDPLLMVFEYMEHGDLNKFLRSHGPdaaflasedsapgeLTLSQLLHIAVQIASGMVYLASQHFVHRDLATRNCLVGTN 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38570135 152 GDVKLADFGVAAKITATIAKRksfIG----TPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05049 159 LVVKIGDFGMSRDIYSTDYYR---VGghtmLPIrWMPPESILYRK---FTTESDVWSFGVVLWEI 217
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
15-272 1.53e-09

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 59.49  E-value: 1.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  15 NPQQdYELVQRVGSGTYGdvykarNVHTGELAA---VKIIKLEPG----DDFslIQQEIFMVKeCKHCNIVAYFGSYLSR 87
Cdd:cd05114   2 NPSE-LTFMKELGSGLFG------VVRLGKWRAqykVAIKAIREGamseEDF--IEEAKVMMK-LTHPKLVQLYGVCTQQ 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  88 EKLWICMEYCGGGSLQD-IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd05114  72 KPIYIVTEFMENGCLLNyLRQRRGKLSRDMLLSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVL 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 167 ATIAKRKSFIGTPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIEL-GELQPPMFDLHPMRALFLMSKSN-FQPPKLKDK 243
Cdd:cd05114 152 DDQYTSSSGAKFPVkWSPPEVFNYSK---FSSKSDVWSFGVLMWEVfTEGKMPFESKSNYEVVEMVSRGHrLYRPKLASK 228
                       250       260       270
                ....*....|....*....|....*....|..
gi 38570135 244 TKWS---STFHnfvkialtKNPKKRPTAERLL 272
Cdd:cd05114 229 SVYEvmySCWH--------EKPEGRPTFADLL 252
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
20-277 2.13e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 59.20  E-value: 2.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS-----LIQQEIFMVKECKHC--NIVAYFGSYLSREKLWI 92
Cdd:cd14102   2 YQVGSVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGtlngvMVPLEIVLLKKVGSGfrGVIKLLDWYERPDGFLI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 CMEYcgGGSLQDIY-HVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLADFGVAAKITAT 168
Cdd:cd14102  82 VMER--PEPVKDLFdFITekGALDEDTARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVdLRTGELKLIDFGSGALLKDT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IakRKSFIGTPYWMAPEVAAVEKNGGYNqlCDIWAVGITAIEL--GELqPPMFDLHPMRAlflmsksnfqppKLKDKTKW 246
Cdd:cd14102 160 V--YTDFDGTRVYSPPEWIRYHRYHGRS--ATVWSLGVLLYDMvcGDI-PFEQDEEILRG------------RLYFRRRV 222
                       250       260       270
                ....*....|....*....|....*....|.
gi 38570135 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14102 223 SPECQQLIKWCLSLRPSDRPTLEQIFDHPWM 253
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
116-336 2.28e-09

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 60.86  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  116 QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI-TATIAKRKSFIGTPYWMAPEVAAVEkngG 194
Cdd:PHA03210 268 QTRAIMKQLLCAVEYIHDKKLIHRDIKLENIFLNCDGKIVLGDFGTAMPFeKEREAFDYGWVGTVATNSPEILAGD---G 344
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  195 YNQLCDIWAVGITAIEL----------GELQPPMFDLHPMRALFLMSKSNFQPP-KLKDKTKWSSTFHNFVKI-ALTKNP 262
Cdd:PHA03210 345 YCEITDIWSCGLILLDMlshdfcpigdGGGKPGKQLLKIIDSLSVCDEEFPDPPcKLFDYIDSAEIDHAGHSVpPLIRNL 424
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135  263 KKRPTAE----RLLTHTFVAQPGLSRALAVELLD-KVNNPDNHAHYTEADDDDFEPhaiIRHTIRSTNRNARAERTASE 336
Cdd:PHA03210 425 GLPADFEyplvKMLTFDWHLRPGAAELLALPLFSaEEEEEILFIHGLKSGAAHFKP---IKPACRIESDTAALPLSMSD 500
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
22-211 2.68e-09

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 59.28  E-value: 2.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  22 LVQRVGSGTYGDVYKAR--NVHTGE---LAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEY 96
Cdd:cd05093   9 LKRELGEGAFGKVFLAEcyNLCPEQdkiLVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  97 CGGGSLQDIYHVTGP-------------LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd05093  89 MKHGDLNKFLRAHGPdavlmaegnrpaeLTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 168
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKR-KSFIGTPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIEL 211
Cdd:cd05093 169 DVYSTDYYRvGGHTMLPIrWMPPESIMYRK---FTTESDVWSLGVVLWEI 215
STKc_KIS cd14020
Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called ...
20-280 2.85e-09

Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KIS (or UHMK1) contains an N-terminal kinase domain and a C-terminal domain with a UHM motif, a protein interaction motif initially found in the pre-mRNA splicing factor U2AF. It phosphorylates the splicing factor SF1, which enhances binding to the splice site to promote spliceosome assembly. KIS was first identified as a kinase that interacts with stathmin, a phosphoprotein that plays a role in axon development and microtubule dynamics. It localizes in RNA granules in neurons and is important in neurite outgrowth. The KIS/UHMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270922 [Multi-domain]  Cd Length: 285  Bit Score: 59.18  E-value: 2.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGEL--AAVKIIKLEP-----GDDFSLIQQEIFMVKECKHCNIVAYFGSYLSreklwi 92
Cdd:cd14020   2 WEVQSRLGQGSSASVYRVSSGRGADQptSALKEFQLDHqgsqeSGDYGFAKERAALEQLQGHRNIVTLYGVFTN------ 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  93 cmEYCGGGS----LQDIYHVTgpLSEL------------QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLT-DHGDVK 155
Cdd:cd14020  76 --HYSANVPsrclLLELLDVS--VSELllrssnqgcsmwMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSaEDECFK 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 156 LADFGVAAKITATIAKrksFIGTPYWMAPEV--------AAVEKNGGYNQLCDIWAVGITAIELgelqppmfdlhpmral 227
Cdd:cd14020 152 LIDFGLSFKEGNQDVK---YIQTDGYRAPEAelqnclaqAGLQSETECTSAVDLWSLGIVLLEM---------------- 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38570135 228 flmsksnFQPPKLKDKTK---WSS---------------------TFH--NFVKIALTKNPKKRPTAERLLTHTFVAQP 280
Cdd:cd14020 213 -------FSGMKLKHTVRsqeWKDnssaiidhifasnavvnpaipAYHlrDLIKSMLHNDPGKRATAEAALCSPFFSIP 284
PTKc_Aatyk cd05042
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs ...
24-274 3.18e-09

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Aatyk subfamily is also referred to as the lemur tyrosine kinase (Lmtk) subfamily. It consists of Aatyk1 (Lmtk1), Aatyk2 (Lmtk2, Brek), Aatyk3 (Lmtk3), and similar proteins. Aatyk proteins are mostly receptor PTKs (RTKs) containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk1 does not contain a transmembrane segment and is a cytoplasmic (or nonreceptor) kinase. Aatyk proteins are classified as PTKs based on overall sequence similarity and the phylogenetic tree. However, analysis of catalytic residues suggests that Aatyk proteins may be multispecific kinases, functioning also as serine/threonine kinases. They are involved in neural differentiation, nerve growth factor (NGF) signaling, apoptosis, and spermatogenesis. The Aatyk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270638 [Multi-domain]  Cd Length: 269  Bit Score: 58.75  E-value: 3.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  24 QRVGSGTYGDVYKARnVHTGELAAVKIIKlEPGDDFSLIQQEIFM-----VKECKHCNIVAYFGSYLSREKLWICMEYCG 98
Cdd:cd05042   1 QEIGNGWFGKVLLGE-IYSGTSVAQVVVK-ELKASANPKEQDTFLkegqpYRILQHPNILQCLGQCVEAIPYLLVMEFCD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  99 GGSLQDIY-----HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKitatiAKRK 173
Cdd:cd05042  79 LGDLKAYLrsereHERGDSDTRTLQRMACEVAAGLAHLHKLNFVHSDLALRNCLLTSDLTVKIGDYGLAHS-----RYKE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 174 SFIGTP-------YWMAPE-VAAVEKN---GGYNQLCDIWAVGITAIELGEL-QPPMFDLHPMRAL-FLMSKSNFQPPKL 240
Cdd:cd05042 154 DYIETDdklwfplRWTAPElVTEFHDRllvVDQTKYSNIWSLGVTLWELFENgAQPYSNLSDLDVLaQVVREQDTKLPKP 233
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 38570135 241 KDKTKWSSTFHNFVKIALtKNPKKRPTAE---RLLTH 274
Cdd:cd05042 234 QLELPYSDRWYEVLQFCW-LSPEQRPAAEdvhLLLTY 269
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
12-238 3.32e-09

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 59.31  E-value: 3.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  12 LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELA----AVKIIKLEPGDDFSL-IQQEIFMVKECKHCNIVAYFGSYLS 86
Cdd:cd05110   1 LRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVkipvAIKILNETTGPKANVeFMDEALIMASMDHPHLVRLLGVCLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 REKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKIT 166
Cdd:cd05110  81 PTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLE 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 167 ATIAKRKSFIG-TPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL-FLMSKSNF--QPP 238
Cdd:cd05110 161 GDEKEYNADGGkMPIkWMALECIHYRK---FTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIpDLLEKGERlpQPP 234
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
10-267 5.97e-09

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 58.88  E-value: 5.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  10 DILRRNPQQD----YELVQRVGSGTYGDVYKARNVHTgelaaVKIIKLEPGDDFSLIQQEIFMvkeckhcNIVAYFGSYL 85
Cdd:cd05105 152 DIFGINPADEstrsYVILSFENKGDYMDMKQADTTQY-----VPMLEIKEASKYSDIQRSNYD-------RPASYKGSND 219
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  86 SREKLWICMEYCGGGSLQDIYHVTgplseLQIAyvcretlQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI 165
Cdd:cd05105 220 SEVKNLLSDDGSEGLTTLDLLSFT-----YQVA-------RGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 287
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 166 ---TATIAKRKSFIGTPyWMAPEvaAVEKNgGYNQLCDIWAVGITAIEL----GELQPPMFD----LHPMRALFLMSKSN 234
Cdd:cd05105 288 mhdSNYVSKGSTFLPVK-WMAPE--SIFDN-LYTTLSDVWSYGILLWEIfslgGTPYPGMIVdstfYNKIKSGYRMAKPD 363
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 235 FQPPKLKDKTK--WSStfhnfvkialtkNPKKRPT 267
Cdd:cd05105 364 HATQEVYDIMVkcWNS------------EPEKRPS 386
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
111-211 6.16e-09

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 58.99  E-value: 6.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK--------ITATIAkrksfigTPYWM 182
Cdd:cd07853  99 PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVeepdeskhMTQEVV-------TQYYR 171
                        90       100
                ....*....|....*....|....*....
gi 38570135 183 APEVAAVEKNggYNQLCDIWAVGITAIEL 211
Cdd:cd07853 172 APEILMGSRH--YTSAVDIWSVGCIFAEL 198
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
20-274 8.96e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 57.17  E-value: 8.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKII------KLEPGDDFSLIQQEIFMVKEC----KHCNIVAYFGSYLSREK 89
Cdd:cd14101   2 YTMGNLLGKGGFGTVYAGHRISDGLQVAIKQIsrnrvqQWSKLPGVNPVPNEVALLQSVgggpGHRGVIRLLDWFEIPEG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICME---YCgggslQDIY-HVT--GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL-TDHGDVKLADFGVA 162
Cdd:cd14101  82 FLLVLErpqHC-----QDLFdYITerGALDESLARRFFKQVVEAVQHCHSKGVVHRDIKDENILVdLRTGDIKLIDFGSG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 163 AKITATIakRKSFIGTPYWMAPEVAAVEKnggYNQL-CDIWAVGITAIEL--GELqPPMFDLHPMRAlflmsksnfqppK 239
Cdd:cd14101 157 ATLKDSM--YTDFDGTRVYSPPEWILYHQ---YHALpATVWSLGILLYDMvcGDI-PFERDTDILKA------------K 218
                       250       260       270
                ....*....|....*....|....*....|....*
gi 38570135 240 LKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTH 274
Cdd:cd14101 219 PSFNKRVSNDCRSLIRSCLAYNPSDRPSLEQILLH 253
STKc_HIPK3 cd14229
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; ...
20-211 9.82e-09

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK3 is a Fas-interacting protein that induces FADD (Fas-associated death domain) phosphorylation and mediates FasL-induced JNK activation. Overexpression of HIPK3 does not affect cell death, however its expression in prostate cancer cells contributes to increased resistance to Fas receptor-mediated apoptosis. HIPK3 also plays a role in regulating steroidogenic gene expression. In response to cAMP, HIPK3 activates the phosphorylation of JNK and c-Jun, leading to increased activity of the transcription factor SF-1 (Steroidogenic factor 1), a key regulator for steroid biosynthesis in the gonad and adrenal gland. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271131 [Multi-domain]  Cd Length: 330  Bit Score: 57.73  E-value: 9.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPgddfSLIQQ---EIFMV-----KECKHCNIVAYFGSYLSREKLW 91
Cdd:cd14229   2 YEVLDFLGRGTFGQVVKCWKRGTNEIVAVKILKNHP----SYARQgqiEVGILarlsnENADEFNFVRAYECFQHRNHTC 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  92 ICMEYCGggslQDIYHV--TGPLSELQIAyVCRETLQ----GLAYLHTKGKMHRDIKGANILLTD----HGDVKLADFGV 161
Cdd:cd14229  78 LVFEMLE----QNLYDFlkQNKFSPLPLK-VIRPILQqvatALKKLKSLGLIHADLKPENIMLVDpvrqPYRVKVIDFGS 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 38570135 162 AAKITATIAkrKSFIGTPYWMAPEVAAvekNGGYNQLCDIWAVGITAIEL 211
Cdd:cd14229 153 ASHVSKTVC--STYLQSRYYRAPEIIL---GLPFCEAIDMWSLGCVIAEL 197
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
126-228 1.24e-08

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 58.10  E-value: 1.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKI---TATIAKRKSFIGTPyWMAPEVAAvekNGGYNQLCDIW 202
Cdd:cd05107 250 NGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLK-WMAPESIF---NNLYTTLSDVW 325
                        90       100
                ....*....|....*....|....*.
gi 38570135 203 AVGITAIELGELQPPMFDLHPMRALF 228
Cdd:cd05107 326 SFGILLWEIFTLGGTPYPELPMNEQF 351
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
18-206 1.34e-08

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 57.37  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL------EPGDDF-SLIQQEIFMVKECKHCNIVAYFGSY-LSREK 89
Cdd:cd14040   6 ERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLnkswrdEKKENYhKHACREYRIHKELDHPRIVKLYDYFsLDTDT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  90 LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK--MHRDIKGANILLTDH---GDVKLADFGVAAK 164
Cdd:cd14040  86 FCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPpiIHYDLKPGNILLVDGtacGEIKITDFGLSKI 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 38570135 165 I------TATIAKRKSFIGTPYWMAPEVAAVEKN-GGYNQLCDIWAVGI 206
Cdd:cd14040 166 MdddsygVDGMDLTSQGAGTYWYLPPECFVVGKEpPKISNKVDVWSVGV 214
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
16-216 1.35e-08

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 57.29  E-value: 1.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  16 PQQDYELVQRVGSGTYGDVY------------KARNVHTGE--LAAVKIIKLEPG----DDFsliQQEIFMVKECKHCNI 77
Cdd:cd05097   3 PRQQLRLKEKLGEGQFGEVHlceaeglaeflgEGAPEFDGQpvLVAVKMLRADVTktarNDF---LKEIKIMSRLKNPNI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIA------------YVCRETLQGLAYLHTKGKMHRDIKGAN 145
Cdd:cd05097  80 IRLLGVCVSDDPLCMITEYMENGDLNQFLSQREIESTFTHAnnipsvsianllYMAVQIASGMKYLASLNFVHRDLATRN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 146 ILLTDHGDVKLADFGVAakitatiakRKSFIGTPY-----------WMAPEVAAVeknGGYNQLCDIWAVGITAIELGEL 214
Cdd:cd05097 160 CLVGNHYTIKIADFGMS---------RNLYSGDYYriqgravlpirWMAWESILL---GKFTTASDVWAFGVTLWEMFTL 227

                ....*
gi 38570135 215 ---QP 216
Cdd:cd05097 228 ckeQP 232
PTKc_TrkC cd05094
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze ...
17-223 1.45e-08

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkC is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkC to its ligand, neurotrophin 3 (NT3), results in receptor oligomerization and activation of the catalytic domain. TrkC is broadly expressed in the nervous system and in some non-neural tissues including the developing heart. NT3/TrkC signaling plays an important role in the innervation of the cardiac conducting system and the development of smooth muscle cells. Mice deficient with NT3 and TrkC have multiple heart defects. NT3/TrkC signaling is also critical for the development and maintenance of enteric neurons that are important for the control of gut peristalsis. The TrkC subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270676 [Multi-domain]  Cd Length: 287  Bit Score: 56.94  E-value: 1.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  17 QQDYELVQRVGSGTYGDVYKARNVHTGE-----LAAVKIIK---LEPGDDFsliQQEIFMVKECKHCNIVAYFGSYLSRE 88
Cdd:cd05094   4 RRDIVLKRELGEGAFGKVFLAECYNLSPtkdkmLVAVKTLKdptLAARKDF---QREAELLTNLQHDHIVKFYGVCGDGD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSLQDIYHVTGP----------------LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG 152
Cdd:cd05094  81 PLIMVFEYMKHGDLNKFLRAHGPdamilvdgqprqakgeLGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGANL 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 38570135 153 DVKLADFGVAAKITATIAKR-KSFIGTPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIELGEL-QPPMFDLHP 223
Cdd:cd05094 161 LVKIGDFGMSRDVYSTDYYRvGGHTMLPIrWMPPESIMYRK---FTTESDVWSFGVILWEIFTYgKQPWFQLSN 231
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
26-210 1.54e-08

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 56.88  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYG----DVYKARNVHTGelAAVKIIKL--EPGDDFSLIQQEIFMvKECKHCNIVAYFGsYLSREKLWICMEYCGG 99
Cdd:cd05115  12 LGSGNFGcvkkGVYKMRKKQID--VAIKVLKQgnEKAVRDEMMREAQIM-HQLDNPYIVRMIG-VCEAEALMLVMEMASG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 100 GSLQDIyhVTGPLSEL---QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA--TIAKRKS 174
Cdd:cd05115  88 GPLNKF--LSGKKDEItvsNVVELMHQVSMGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGAddSYYKARS 165
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 38570135 175 FIGTPY-WMAPEVAAVEKnggYNQLCDIWAVGITAIE 210
Cdd:cd05115 166 AGKWPLkWYAPECINFRK---FSSRSDVWSYGVTMWE 199
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
18-214 1.57e-08

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 56.93  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  18 QDYELVQRVGSGTYGDVYKARNVHTGEL--AAVKIIK--LEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWIC 93
Cdd:cd05089   2 EDIKFEDVIGEGNFGQVIKAMIKKDGLKmnAAIKMLKefASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  94 MEYCGGGSLQDI----------------YHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLA 157
Cdd:cd05089  82 IEYAPYGNLLDFlrksrvletdpafakeHGTASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIA 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 158 DFGVAAKITATIAKRKSFIGTpYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGEL 214
Cdd:cd05089 162 DFGLSRGEEVYVKKTMGRLPV-RWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSL 214
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
20-223 3.90e-08

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 55.54  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRvgsGTYGDVYKA--RNVHTGELAA-VKIIKlepgDDFSLIQ-----QEIFMVKECKHCNI-----VAYFGSyls 86
Cdd:cd05043  11 SDLLQE---GTFGRIFHGilRDEKGKEEEVlVKTVK----DHASEIQvtmllQESSLLYGLSHQNLlpilhVCIEDG--- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  87 rEKLWICMEYCGGGSL----QDIYHV--TGP--LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLAD 158
Cdd:cd05043  81 -EKPMVLYPYMNWGNLklflQQCRLSeaNNPqaLSTQQLVHMALQIACGMSYLHRRGVIHKDIAARNCVIDDELQVKITD 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38570135 159 FGVAakitatiakRKSFIGTPY-----------WMAPEvaAVEKNGgYNQLCDIWAVGITAIELGEL-QPPMFDLHP 223
Cdd:cd05043 160 NALS---------RDLFPMDYHclgdnenrpikWMSLE--SLVNKE-YSSASDVWSFGVLLWELMTLgQTPYVEIDP 224
PTKc_Aatyk2 cd05086
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs ...
23-274 4.69e-08

Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk2 is a member of the Aatyk subfamily of proteins, which are receptor kinases containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk2 is also called lemur tyrosine kinase 2 (Lmtk2) or brain-enriched kinase (Brek). It is expressed at high levels in early postnatal brain, and has been shown to play a role in nerve growth factor (NGF) signaling. Studies with knockout mice reveal that Aatyk2 is essential for late stage spermatogenesis. Although it is classified as a PTK based on sequence similarity and the phylogenetic tree, Aatyk2 has been functionally characterized as a serine/threonine kinase. The Aatyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270669 [Multi-domain]  Cd Length: 271  Bit Score: 55.26  E-value: 4.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  23 VQRVGSGTYGDVYKARnVHTGELAAVKIIK--------------LEPGDDFSLIQqeifmvkeckHCNIVAYFGSYLSRE 88
Cdd:cd05086   2 IQEIGNGWFGKVLLGE-IYTGTSVARVVVKelkasanpkeqddfLQQGEPYYILQ----------HPNILQCVGQCVEAI 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  89 KLWICMEYCGGGSL-----QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd05086  71 PYLLVFEFCDLGDLktylaNQQEKLRGDSQIMLLQRMACEIAAGLAHMHKHNFLHSDLALRNCYLTSDLTVKVGDYGIGF 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 ---KITATIAKRKSFIGTpYWMAPEVAAVEKNG----GYNQLCDIWAVGITAIELGE-LQPPMFDLHPMRAL-FLMSKSN 234
Cdd:cd05086 151 sryKEDYIETDDKKYAPL-RWTAPELVTSFQDGllaaEQTKYSNIWSLGVTLWELFEnAAQPYSDLSDREVLnHVIKERQ 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 38570135 235 FQPPKLKDKTKWSSTFHNFVKIALTkNPKKRPTAE---RLLTH 274
Cdd:cd05086 230 VKLFKPHLEQPYSDRWYEVLQFCWL-SPEKRPTAEevhRLLTY 271
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
20-277 5.20e-08

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 55.86  E-value: 5.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKlepgDDFSLIQQEIFMVKECKH---------CNIVAYFGSYLSREKL 90
Cdd:cd14225  45 YEILEVIGKGSFGQVVKALDHKTNEHVAIKIIR----NKKRFHHQALVEVKILDAlrrkdrdnsHNVIHMKEYFYFRNHL 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  91 WICMEYCGggslQDIYHVTGP-----LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHG--DVKLADFGVAA 163
Cdd:cd14225 121 CITFELLG----MNLYELIKKnnfqgFSLSLIRRFAISLLQCLRLLYRERIIHCDLKPENILLRQRGqsSIKVIDFGSSC 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAkrkSFIGTPYWMAPEVAAvekngG--YNQLCDIWAVGITAIEL--------GELQP-------PMFDLHPM-- 224
Cdd:cd14225 197 YEHQRVY---TYIQSRFYRSPEVIL-----GlpYSMAIDMWSLGCILAELytgyplfpGENEVeqlacimEVLGLPPPel 268
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 225 ------RALFLMSKSNfqpPKL----KDKTKWSST-------------FHNFVKIALTKNPKKRPTAERLLTHTFV 277
Cdd:cd14225 269 ienaqrRRLFFDSKGN---PRCitnsKGKKRRPNSkdlasalktsdplFLDFIRRCLEWDPSKRMTPDEALQHEWI 341
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
26-271 8.08e-08

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 54.46  E-value: 8.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKAR-NVHTGEL--AAVKIIKLEpGDDFSLIQQ---EIFMVKECKHCNIVAYFGSYL---SREKLWICM-- 94
Cdd:cd05035   7 LGEGEFGSVMEAQlKQDDGSQlkVAVKTMKVD-IHTYSEIEEflsEAACMKDFDHPNVMRLIGVCFtasDLNKPPSPMvi 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 -EYCGGGSLQD--IYHVTGPLSElqiaYVCRETL--------QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAA 163
Cdd:cd05035  86 lPFMKHGDLHSylLYSRLGGLPE----KLPLQTLlkfmvdiaKGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 164 KITATIAKRKSFIGT-PY-WMAPEVAAvekNGGYNQLCDIWAVGITAIEL---GELQPPMFDLHPMRALFLMSKSNFQPP 238
Cdd:cd05035 162 KIYSGDYYRQGRISKmPVkWIALESLA---DNVYTSKSDVWSFGVTMWEIatrGQTPYPGVENHEIYDYLRNGNRLKQPE 238
                       250       260       270
                ....*....|....*....|....*....|...
gi 38570135 239 KLKDKTKWSSTFhnfvkiALTKNPKKRPTAERL 271
Cdd:cd05035 239 DCLDEVYFLMYF------CWTVDPKDRPTFTKL 265
STKc_HIPK cd14211
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs ...
20-211 8.55e-08

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). They show speckled localization in the nucleus, apart from the nucleoles. They play roles in the regulation of many nuclear pathways including gene transcription, cell survival, proliferation, differentiation, development, and DNA damage response. Vertebrates contain three HIPKs (HIPK1-3) and mammals harbor an additional family member HIPK4, which does not contain a homeobox-interacting domain and is localized in the cytoplasm. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors and it regulates gene transcription during development and in DNA damage response. The HIPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271113 [Multi-domain]  Cd Length: 329  Bit Score: 55.15  E-value: 8.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDfSLIQQEIFMV-----KECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd14211   1 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA-RQGQIEVSILsrlsqENADEFNFVRAYECFQHKNHTCLVF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGggslQDIYHVT-----GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGD----VKLADFGVAAKI 165
Cdd:cd14211  80 EMLE----QNLYDFLkqnkfSPLPLKYIRPILQQVLTALLKLKSLGLIHADLKPENIMLVDPVRqpyrVKVIDFGSASHV 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 38570135 166 TATIAkrKSFIGTPYWMAPEVAAvekngG--YNQLCDIWAVGITAIEL 211
Cdd:cd14211 156 SKAVC--STYLQSRYYRAPEIIL-----GlpFCEAIDMWSLGCVIAEL 196
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
34-276 8.99e-08

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 54.64  E-value: 8.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  34 VYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIF---MVKECK------HCNIVAYFGSYL-SREKLWICME--YCgggS 101
Cdd:cd14011  12 IYNGSKKSTKQEVSVFVFEKKQLEEYSKRDREQIlelLKRGVKqltrlrHPRILTVQHPLEeSRESLAFATEpvFA---S 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 102 LQDI--YHVTGP----------LSELQIAYVCRETLQGLAYLHTKGKM-HRDIKGANILLTDHGDVKLADFGVAAKITAT 168
Cdd:cd14011  89 LANVlgERDNMPspppelqdykLYDVEIKYGLLQISEALSFLHNDVKLvHGNICPESVVINSNGEWKLAGFDFCISSEQA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 169 IAKRKSFIG-----------TPYWMAPEVAAVEKNGGYNqlcDIWAVGITAIELGELQPPMFDlhpMRALFLMSKSNFQP 237
Cdd:cd14011 169 TDQFPYFREydpnlpplaqpNLNYLAPEYILSKTCDPAS---DMFSLGVLIYAIYNKGKPLFD---CVNNLLSYKKNSNQ 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 38570135 238 ---PKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Cdd:cd14011 243 lrqLSLSLLEKVPEELRDHVKTLLNVTPEVRPDAEQLSKIPF 284
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
26-206 9.41e-08

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 54.20  E-value: 9.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  26 VGSGTYGDVYKA--RNVHTGELAAVKIIKLEpGDDFSL---IQQEIFMVKECKHCNIVAYFGsYLSREKLWICMEYCGGG 100
Cdd:cd05116   3 LGSGNFGTVKKGyyQMKKVVKTVAVKILKNE-ANDPALkdeLLREANVMQQLDNPYIVRMIG-ICEAESWMLVMEMAELG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135 101 SLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITA--TIAKRKSFIGT 178
Cdd:cd05116  81 PLNKFLQKNRHVTEKNITELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAdeNYYKAQTHGKW 160
                       170       180
                ....*....|....*....|....*....
gi 38570135 179 PY-WMAPEVAAVEKnggYNQLCDIWAVGI 206
Cdd:cd05116 161 PVkWYAPECMNYYK---FSSKSDVWSFGV 186
PTKc_Tie2 cd05088
Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the ...
19-214 1.15e-07

Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie2 is a receptor PTK (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie2 is expressed mainly in endothelial cells and hematopoietic stem cells. It is also found in a subset of tumor-associated monocytes and eosinophils. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. Tie2 signaling plays key regulatory roles in vascular integrity and quiescence, and in inflammation. The Tie2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133219 [Multi-domain]  Cd Length: 303  Bit Score: 54.23  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  19 DYELVQRVGSGTYGDVYKARNVHTGEL--AAVKIIK-LEPGDDFSLIQQEI-FMVKECKHCNIVAYFGSYLSREKLWICM 94
Cdd:cd05088   8 DIKFQDVIGEGNFGQVLKARIKKDGLRmdAAIKRMKeYASKDDHRDFAGELeVLCKLGHHPNIINLLGACEHRGYLYLAI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38570135  95 EYCGGGSLQD---------------IYHVTGP-LSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLAD 158
Cdd:cd05088  88 EYAPHGNLLDflrksrvletdpafaIANSTAStLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIAD 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 38570135 159 FGVAAKITATIAKRKSFIGTpYWMAPEVAAVEKnggYNQLCDIWAVGITAIELGEL 214
Cdd:cd05088 168 FGLSRGQEVYVKKTMGRLPV-RWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSL 219
STKc_SNT7_plant cd14013
Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the ...
117-185 1.93e-07

Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNT7 is a plant thylakoid-associated kinase that is essential in short- and long-term acclimation responses to cope with various light conditions in order to maintain photosynthetic redox poise for optimal photosynthetic performance. Short-term response involves state transitions over periods of minutes while the long-term response (LTR) occurs over hours to days and involves changing the relative amounts of photosystems I and II. SNT7 acts as a redox sensor and a signal transducer for both responses, which are triggered by the redox state of the plastoquinone (PQ) pool. It is positioned at the top of a phosphorylation cascade that induces state transitions by phosphorylating light-harvesting complex II (LHCII), and triggers the LTR through the phosphorylation of chloroplast proteins. The SNT7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270915 [Multi-domain]  Cd Length: 318  Bit Score: 53.98  E-value: 1.93e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38570135 117 IAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDH-GDVKLADFGVAAKITATIA-KRKSFIGTPYWMAPE 185
Cdd:cd14013 122 IKSIMRQILVALRKLHSTGIVHRDVKPQNIIVSEGdGQFKIIDLGAAADLRIGINyIPKEFLLDPRYAPPE 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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