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Conserved domains on  [gi|1613448914|ref|NP_942017|]
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epidermal growth factor-like protein 7 isoform 1 precursor [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10540348)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 42-95 1.92e-16

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 72.07  E-value: 1.92e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1613448914  42 SETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRRSPgVTPARPRYACCPGWKR 95
Cdd:pfam07546  17 TESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
138-163 2.28e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*...
gi 1613448914 138 DVDECSTGEASCPQR--CVNTVGSYWCQ 163
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECR 28
PCRF super family cl40670
This domain is found in peptide chain release factors;
197-222 2.19e-03

This domain is found in peptide chain release factors;


The actual alignment was detected with superfamily member PRK00591:

Pssm-ID: 477417 [Multi-domain]  Cd Length: 359  Bit Score: 38.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1613448914 197 MAREEVYRLQARVDVLEQKLQLVLAP 222
Cdd:PRK00591   79 MAKEELKELEERLEELEEELKILLLP 104
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-136 4.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 4.52e-03
                          10        20
                  ....*....|....*....|....*....
gi 1613448914 111 PCGNGGSCI-RPG--HCRCPVGWQGDTCQ 136
Cdd:cd00054    10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 42-95 1.92e-16

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 72.07  E-value: 1.92e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1613448914  42 SETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRRSPgVTPARPRYACCPGWKR 95
Cdd:pfam07546  17 TESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
138-163 2.28e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*...
gi 1613448914 138 DVDECSTGEASCPQR--CVNTVGSYWCQ 163
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECR 28
prfA PRK00591
peptide chain release factor 1; Validated
 197-222 2.19e-03

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 38.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1613448914 197 MAREEVYRLQARVDVLEQKLQLVLAP 222
Cdd:PRK00591   79 MAKEELKELEERLEELEEELKILLLP 104
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-136 4.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 4.52e-03
                          10        20
                  ....*....|....*....|....*....
gi 1613448914 111 PCGNGGSCI-RPG--HCRCPVGWQGDTCQ 136
Cdd:cd00054    10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 42-95 1.92e-16

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 72.07  E-value: 1.92e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1613448914  42 SETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRRSPgVTPARPRYACCPGWKR 95
Cdd:pfam07546  17 TESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
138-163 2.28e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*...
gi 1613448914 138 DVDECSTGEASCPQR--CVNTVGSYWCQ 163
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECR 28
prfA PRK00591
peptide chain release factor 1; Validated
 197-222 2.19e-03

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 38.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1613448914 197 MAREEVYRLQARVDVLEQKLQLVLAP 222
Cdd:PRK00591   79 MAKEELKELEERLEELEEELKILLLP 104
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 111-136 4.52e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.15  E-value: 4.52e-03
                          10        20
                  ....*....|....*....|....*....
gi 1613448914 111 PCGNGGSCI-RPG--HCRCPVGWQGDTCQ 136
Cdd:cd00054    10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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