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Conserved domains on  [gi|197276668|ref|NP_940974|]
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speriolin isoform 1 [Homo sapiens]

Protein Classification

Speriolin_N and Speriolin_C domain-containing protein( domain architecture ID 12171954)

Speriolin_N and Speriolin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Speriolin_C pfam15059
Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein ...
 445-591 4.74e-70

Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein speriolin.


:

Pssm-ID: 464476  Cd Length: 148  Bit Score: 222.56  E-value: 4.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  445 LVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPAL 524
Cdd:pfam15059   1 VVGEIAFQLDRRILSYVFPGRTRLYGFTVSNIPEKIKQVSTNPLTGKVDEEQRAELTERYESLMERLKKLGYNPDVHPTF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  525 TEQLVNAYGILRERPELAASEGGPY-TVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW 591
Cdd:pfam15059  81 SEFIVNTYGILKQRPELGDIDDYAYnDPDYLRKLVIDVVPPKFLKDSLLLLNCLCELSKDDGKPLFIW 148
Speriolin_N pfam15058
Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein ...
 1-228 3.16e-68

Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein speriolin.


:

Pssm-ID: 434426 [Multi-domain]  Cd Length: 196  Bit Score: 219.53  E-value: 3.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668    1 MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAiktqagglgisgftsgLGEATAGLSSRQNNGVFLPPSPAV 80
Cdd:pfam15058   1 MSLLTPYEGLRHQIERLVRENEELKKQVRLLRENQELKRA----------------LGEACAGRCGRQQRGVFLPPVPAY 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   81 ANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLP 160
Cdd:pfam15058  65 ASEPCSPGPGGRALAPLAGMPDTPQQSAEEGSLVDPLTSSLEDLLSGHAPLSQEDCQACQTTDPVAAPPGRTLASSLGLP 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  161 STGTLTPSSLVAGPVAMSQSSPLIAPvmgtvavslsspllssTATPPGVSQNLLANPMSNLVLPEAPR 228
Cdd:pfam15058 145 STGFLTPSSPRAGTVAVSLSSPLLSS----------------TATPVGVNQNTLQNPLADKTLPEVPR 196
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 116-383 3.64e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  116 PLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPvmgtvAVSL 195
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-----PTTA 2764

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  196 SSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTkvPLSTEPPQSTqdPEPLSMA 275
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS--PAGPLPPPTS--AQPTAPP 2840

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  276 FAGAPLQTSTPIGamGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTT 355
Cdd:PHA03247 2841 PPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                         250       260
                  ....*....|....*....|....*...
gi 197276668  356 HIAQgAPHPPSRMHNSPTQNLPVPHCPP 383
Cdd:PHA03247 2919 PQPQ-PPPPPQPQPPPPPPPRPQPPLAP 2945
 
Name Accession Description Interval E-value
Speriolin_C pfam15059
Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein ...
 445-591 4.74e-70

Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein speriolin.


Pssm-ID: 464476  Cd Length: 148  Bit Score: 222.56  E-value: 4.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  445 LVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPAL 524
Cdd:pfam15059   1 VVGEIAFQLDRRILSYVFPGRTRLYGFTVSNIPEKIKQVSTNPLTGKVDEEQRAELTERYESLMERLKKLGYNPDVHPTF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  525 TEQLVNAYGILRERPELAASEGGPY-TVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW 591
Cdd:pfam15059  81 SEFIVNTYGILKQRPELGDIDDYAYnDPDYLRKLVIDVVPPKFLKDSLLLLNCLCELSKDDGKPLFIW 148
Speriolin_N pfam15058
Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein ...
 1-228 3.16e-68

Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein speriolin.


Pssm-ID: 434426 [Multi-domain]  Cd Length: 196  Bit Score: 219.53  E-value: 3.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668    1 MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAiktqagglgisgftsgLGEATAGLSSRQNNGVFLPPSPAV 80
Cdd:pfam15058   1 MSLLTPYEGLRHQIERLVRENEELKKQVRLLRENQELKRA----------------LGEACAGRCGRQQRGVFLPPVPAY 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   81 ANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLP 160
Cdd:pfam15058  65 ASEPCSPGPGGRALAPLAGMPDTPQQSAEEGSLVDPLTSSLEDLLSGHAPLSQEDCQACQTTDPVAAPPGRTLASSLGLP 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  161 STGTLTPSSLVAGPVAMSQSSPLIAPvmgtvavslsspllssTATPPGVSQNLLANPMSNLVLPEAPR 228
Cdd:pfam15058 145 STGFLTPSSPRAGTVAVSLSSPLLSS----------------TATPVGVNQNTLQNPLADKTLPEVPR 196
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-383 3.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  116 PLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPvmgtvAVSL 195
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-----PTTA 2764

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  196 SSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTkvPLSTEPPQSTqdPEPLSMA 275
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS--PAGPLPPPTS--AQPTAPP 2840

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  276 FAGAPLQTSTPIGamGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTT 355
Cdd:PHA03247 2841 PPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                         250       260
                  ....*....|....*....|....*...
gi 197276668  356 HIAQgAPHPPSRMHNSPTQNLPVPHCPP 383
Cdd:PHA03247 2919 PQPQ-PPPPPQPQPPPPPPPRPQPPLAP 2945
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 70-434 3.70e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   70 NGVFLPPSPAVANERVLEEVGIMALAPLAEMLTSlQPSATPGSLMSPLTGTLSTLLSGPA--PTSQSSPLTSFLTSPIAG 147
Cdd:pfam03154 178 SGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTlhPQRLPSPHPPLQPMTQPP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  148 PLTGTLASSLGLPS---TGTLTPSSLVAGPVAMSQSSPlIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLP 224
Cdd:pfam03154 257 PPSQVSPQPLPQPSlhgQMPPMPHSLQTGPSHMQHPVP-PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  225 EAPRLRlAEPLrggPTGPQSPACVVPTATTKVPLSTEP-----PQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAf 299
Cdd:pfam03154 336 SQQPPR-EQPL---PPAPLSMPHIKPPPTTPIPQLPNPqshkhPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSA- 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  300 sfNTSDTQAQPSAAQEQVVPASVPTspttsptvtvLASAPALAPQVATSYTPSSTTHIAQGAPHPP-SRMHNSPTQNLPv 378
Cdd:pfam03154 411 --HPPPLQLMPQSQQLPPPPAQPPV----------LTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhPFVPGGPPPITP- 477

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 197276668  379 PHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENP 434
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESP 533
PHA03247 PHA03247
large tegument protein UL36; Provisional
 75-360 3.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   75 PPSPAVANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPA-----PTSQSSPLTSFLTSPIAGP- 148
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArparpPTTAGPPAPAPPAAPAAGPp 2780

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  149 --LTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEA 226
Cdd:PHA03247 2781 rrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  227 PrLRLAEPLRGGPTGPQSPA--CVVPTATTKVPLSTEP---PQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKT---- 297
Cdd:PHA03247 2861 D-VRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprp 2939

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197276668  298 -AFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQG 360
Cdd:PHA03247 2940 qPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
 
Name Accession Description Interval E-value
Speriolin_C pfam15059
Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein ...
 445-591 4.74e-70

Speriolin C-terminus; This family represents the C-terminus of the sperm centrosome protein speriolin.


Pssm-ID: 464476  Cd Length: 148  Bit Score: 222.56  E-value: 4.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  445 LVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPAL 524
Cdd:pfam15059   1 VVGEIAFQLDRRILSYVFPGRTRLYGFTVSNIPEKIKQVSTNPLTGKVDEEQRAELTERYESLMERLKKLGYNPDVHPTF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  525 TEQLVNAYGILRERPELAASEGGPY-TVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW 591
Cdd:pfam15059  81 SEFIVNTYGILKQRPELGDIDDYAYnDPDYLRKLVIDVVPPKFLKDSLLLLNCLCELSKDDGKPLFIW 148
Speriolin_N pfam15058
Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein ...
 1-228 3.16e-68

Speriolin N terminus; This family represents the N-terminus of the sperm centrosome protein speriolin.


Pssm-ID: 434426 [Multi-domain]  Cd Length: 196  Bit Score: 219.53  E-value: 3.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668    1 MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAiktqagglgisgftsgLGEATAGLSSRQNNGVFLPPSPAV 80
Cdd:pfam15058   1 MSLLTPYEGLRHQIERLVRENEELKKQVRLLRENQELKRA----------------LGEACAGRCGRQQRGVFLPPVPAY 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   81 ANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLP 160
Cdd:pfam15058  65 ASEPCSPGPGGRALAPLAGMPDTPQQSAEEGSLVDPLTSSLEDLLSGHAPLSQEDCQACQTTDPVAAPPGRTLASSLGLP 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  161 STGTLTPSSLVAGPVAMSQSSPLIAPvmgtvavslsspllssTATPPGVSQNLLANPMSNLVLPEAPR 228
Cdd:pfam15058 145 STGFLTPSSPRAGTVAVSLSSPLLSS----------------TATPVGVNQNTLQNPLADKTLPEVPR 196
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-383 3.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  116 PLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPvmgtvAVSL 195
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-----PTTA 2764

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  196 SSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTkvPLSTEPPQSTqdPEPLSMA 275
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS--PAGPLPPPTS--AQPTAPP 2840

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  276 FAGAPLQTSTPIGamGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTT 355
Cdd:PHA03247 2841 PPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                         250       260
                  ....*....|....*....|....*...
gi 197276668  356 HIAQgAPHPPSRMHNSPTQNLPVPHCPP 383
Cdd:PHA03247 2919 PQPQ-PPPPPQPQPPPPPPPRPQPPLAP 2945
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 70-434 3.70e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   70 NGVFLPPSPAVANERVLEEVGIMALAPLAEMLTSlQPSATPGSLMSPLTGTLSTLLSGPA--PTSQSSPLTSFLTSPIAG 147
Cdd:pfam03154 178 SGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS-PATSQPPNQTQSTAAPHTLIQQTPTlhPQRLPSPHPPLQPMTQPP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  148 PLTGTLASSLGLPS---TGTLTPSSLVAGPVAMSQSSPlIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLP 224
Cdd:pfam03154 257 PPSQVSPQPLPQPSlhgQMPPMPHSLQTGPSHMQHPVP-PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  225 EAPRLRlAEPLrggPTGPQSPACVVPTATTKVPLSTEP-----PQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAf 299
Cdd:pfam03154 336 SQQPPR-EQPL---PPAPLSMPHIKPPPTTPIPQLPNPqshkhPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSA- 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  300 sfNTSDTQAQPSAAQEQVVPASVPTspttsptvtvLASAPALAPQVATSYTPSSTTHIAQGAPHPP-SRMHNSPTQNLPv 378
Cdd:pfam03154 411 --HPPPLQLMPQSQQLPPPPAQPPV----------LTQSQSLPPPAASHPPTSGLHQVPSQSPFPQhPFVPGGPPPITP- 477

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 197276668  379 PHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENP 434
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESP 533
PHA03247 PHA03247
large tegument protein UL36; Provisional
 93-399 1.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   93 ALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLsGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVA 172
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVSATPLPP-GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  173 GPVAMSQSSPliAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLP--EAPRLRLAEPLRGGPTGPQSPACVVP 250
Cdd:PHA03247 2770 APPAAPAAGP--PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPpaASPAGPLPPPTSAQPTAPPPPPGPPP 2847

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  251 TATT-------------KVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQPSAAQEQV 317
Cdd:PHA03247 2848 PSLPlggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP 2927

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  318 VPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQGAPHPPSRM--HNSPTQNLPVPHCPPHNAHSPPRTSSS 395
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRvpQPAPSREAPASSTPPLTGHSLSRVSSW 3007


                  ....
gi 197276668  396 PASV 399
Cdd:PHA03247 3008 ASSL 3011
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-441 1.49e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  105 QPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPltGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSP-- 182
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRpr 2665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  183 -LIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEaPRLRLAEPLRGGPTGPQS-----------PACVVP 250
Cdd:PHA03247 2666 rARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPE-PAPHALVSATPLPPGPAAarqaspalpaaPAPPAV 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  251 TATTKVPLSTEPPQSTQ------DPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPT 324
Cdd:PHA03247 2745 PAGPATPGGPARPARPPttagppAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  325 SPTTSPTVTVLASAPALAPqvatSYTPSSTTHIAQGAPHPPSRMHNSPTQNLPVPHCPPHNAHS-------PPRTSSSPA 397
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPP----GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpavSRSTESFAL 2900

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 197276668  398 SVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENPRESKQLA 441
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLA 2944
PHA03247 PHA03247
large tegument protein UL36; Provisional
 128-405 2.33e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  128 PAPTSQSSPLTSFLTSPIaGPLTGTLASSLGLPSTGTlTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPP 207
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPS-EPAVTSRARRPDAPPQSA-RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  208 GVSQNLLANPMSNLVLPEAPRlRLAEPLR----GGPTGPQSPA-----CVVPTATTKVPLSTEPPQSTQDPEPLSMAFAG 278
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPG-RVSRPRRarrlGRAAQASSPPqrprrRAARPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  279 A-PLQTSTPIGAMGTPAPKTAfsfntsdtQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAP----------QVAT 347
Cdd:PHA03247 2718 AtPLPPGPAAARQASPALPAA--------PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaagpprrltrPAVA 2789

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 197276668  348 SYTPSSTTHIAQGAPHPPSRMHNSPTQNLPVPHCPPhnAHSPPRTSSSPASVNDSRGP 405
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA--GPLPPPTSAQPTAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-400 7.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   95 APLAEMLTSLQPSATPGSLMSPLTGTLS-TLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAG 173
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSeSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  174 PVAMSQsspliaPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLrggPTGPQSPACVVPTAT 253
Cdd:PHA03247 2845 PPPPSL------PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL---PPDQPERPPQPQAPP 2915

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  254 TKVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQ--------PSAAQEQVVPASVPTS 325
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRvavprfrvPQPAPSREAPASSTPP 2995

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  326 PTTSPTVTVLASAPALAPQVATSYTP-----------------------SSTTHIAQGAPHPPSRMHNSPTQNLPVPHCP 382
Cdd:PHA03247 2996 LTGHSLSRVSSWASSLALHEETDPPPvslkqtlwppddtedsdadslfdSDSERSDLEALDPLPPEPHDPFAHEPDPATP 3075

                         330
                  ....*....|....*...
gi 197276668  383 PHNAHSPPRTSSSPASVN 400
Cdd:PHA03247 3076 EAGARESPSSQFGPPPLS 3093
PHA03247 PHA03247
large tegument protein UL36; Provisional
 75-360 3.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668   75 PPSPAVANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGTLSTLLSGPA-----PTSQSSPLTSFLTSPIAGP- 148
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArparpPTTAGPPAPAPPAAPAAGPp 2780

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  149 --LTGTLASSLGLPSTGTLTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEA 226
Cdd:PHA03247 2781 rrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  227 PrLRLAEPLRGGPTGPQSPA--CVVPTATTKVPLSTEP---PQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKT---- 297
Cdd:PHA03247 2861 D-VRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprp 2939

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197276668  298 -AFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQG 360
Cdd:PHA03247 2940 qPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 224-414 6.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  224 PEAPRLRLAEPLRGGPTGPQSPACVVPTATTKVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIgamgtPAPKTAFSFNT 303
Cdd:PHA03307  123 PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP-----SSPPAEPPPST 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276668  304 SDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQGAPHPPSRMHNSPTQ-------NL 376
Cdd:PHA03307  198 PPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRiweasgwNG 277

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 197276668  377 PVPHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKS 414
Cdd:PHA03307  278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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