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Conserved domains on  [gi|38198663|ref|NP_938167|]
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BTB/POZ domain-containing protein KCTD8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
H1_KCTD8 cd22218
H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium ...
 202-321 3.80e-79

H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium channel tetramerization domain-containing protein 8 (KCTD8), a BTB/POZ domain-containing protein, is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors that determine the pharmacology and kinetics of the receptor response. It generates largely non-desensitizing receptor responses. KCTD8 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD8, which may not be involved in desensitization.


:

Pssm-ID: 409029  Cd Length: 122  Bit Score: 241.89  E-value: 3.80e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 202 QDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFD 281
Cdd:cd22218   3 LDKRSGFITIGYRGSYTMVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRPPEKYTSRFYLKFTYLEQAFD 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 38198663 282 RLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFR 321
Cdd:cd22218  83 RLSEAGFHMVACNSTGTAAFVNQYRDDKIWSSYTEYIFFR 122
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-150 3.68e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


:

Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 205.04  E-value: 3.68e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18396   2 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSR-------RAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALP 74

                        90       100
                ....*....|....*....|....*....
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSPKV 150
Cdd:cd18396  75 DHFPEKERLLREAEYFQLGDLVKLLTPKV 103
 
Name Accession Description Interval E-value
H1_KCTD8 cd22218
H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium ...
 202-321 3.80e-79

H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium channel tetramerization domain-containing protein 8 (KCTD8), a BTB/POZ domain-containing protein, is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors that determine the pharmacology and kinetics of the receptor response. It generates largely non-desensitizing receptor responses. KCTD8 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD8, which may not be involved in desensitization.


Pssm-ID: 409029  Cd Length: 122  Bit Score: 241.89  E-value: 3.80e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 202 QDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFD 281
Cdd:cd22218   3 LDKRSGFITIGYRGSYTMVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRPPEKYTSRFYLKFTYLEQAFD 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 38198663 282 RLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFR 321
Cdd:cd22218  83 RLSEAGFHMVACNSTGTAAFVNQYRDDKIWSSYTEYIFFR 122
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-150 3.68e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 205.04  E-value: 3.68e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18396   2 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSR-------RAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALP 74

                        90       100
                ....*....|....*....|....*....
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSPKV 150
Cdd:cd18396  75 DHFPEKERLLREAEYFQLGDLVKLLTPKV 103
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 46-142 8.18e-15

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 69.93  E-value: 8.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663    46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarRRGELPRDSRARFFIDRDGFLFRYVLDYLRDK-QLALPEHF 124
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLE---------LECDDYDDDTNEYFFDRSPKHFETILNFYRTGgKLHRPEEV 71

                          90
                  ....*....|....*...
gi 38198663   125 PEKErLLREAEYFQLTDL 142
Cdd:pfam02214  72 CLDE-FLEEAEFYGLDEL 88
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 46-145 5.83e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 5.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663     46 VELNVGGQVYVTkHSTLLSVPDSTLASMFSpssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHfp 125
Cdd:smart00225   2 VTLVVGGKKFHA-HKAVLAAHSPYFKALFS----------SDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-- 68

                           90       100
                   ....*....|....*....|
gi 38198663    126 EKERLLREAEYFQLTDLVKL 145
Cdd:smart00225  69 NVEELLELADYLQIPGLVEL 88
 
Name Accession Description Interval E-value
H1_KCTD8 cd22218
H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium ...
 202-321 3.80e-79

H1 domain found in potassium channel tetramerization domain-containing protein 8; Potassium channel tetramerization domain-containing protein 8 (KCTD8), a BTB/POZ domain-containing protein, is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors that determine the pharmacology and kinetics of the receptor response. It generates largely non-desensitizing receptor responses. KCTD8 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD8, which may not be involved in desensitization.


Pssm-ID: 409029  Cd Length: 122  Bit Score: 241.89  E-value: 3.80e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 202 QDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFD 281
Cdd:cd22218   3 LDKRSGFITIGYRGSYTMVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRPPEKYTSRFYLKFTYLEQAFD 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 38198663 282 RLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFR 321
Cdd:cd22218  83 RLSEAGFHMVACNSTGTAAFVNQYRDDKIWSSYTEYIFFR 122
H1_KCTD12b cd22216
H1 domain found in potassium channel tetramerization domain-containing protein 12b; Potassium ...
 204-321 7.15e-74

H1 domain found in potassium channel tetramerization domain-containing protein 12b; Potassium channel tetramerization domain-containing protein 12b (KCTD12b) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors associated with mood disorders. KCTD12b consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


Pssm-ID: 409027  Cd Length: 118  Bit Score: 227.99  E-value: 7.15e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 204 KRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRL 283
Cdd:cd22216   1 RRAGFITIGYRGSYTLGRDSQTDAKFRRVARIMVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFTFLEQAFDKL 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 38198663 284 SEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFR 321
Cdd:cd22216  81 ADAGFHMVACNSTGTCAFAHDQTDDKIWTSYTEYVFYR 118
H1_KCTD16 cd22219
H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium ...
 203-323 6.99e-72

H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium channel tetramerization domain-containing protein 16 (KCTD16) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-) receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. KCTD16 generates largely non-desensitizing receptor responses. It consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD16, which may not be involved in desensitization.


Pssm-ID: 409030  Cd Length: 121  Bit Score: 223.25  E-value: 6.99e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 203 DKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDR 282
Cdd:cd22219   1 DRKWGFITVGYRGSCTMGRESQADAKFRRVPRILVCGRIALAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDM 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 38198663 283 LSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPP 323
Cdd:cd22219  81 LSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREP 121
H1_KCTD12-like cd22204
H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain ...
 206-321 1.09e-71

H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain is found in potassium channel tetramerization domain-containing proteins such as KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), KCTD12b, and KCTD16. They serve as auxiliary gamma-aminobutyric acid type B (GABA-B) receptor subunits that constitute receptor subtypes with distinct functional properties. KCTD12 and -12b generate desensitizing receptor responses while KCTD8 and -16 generate largely non-desensitizing receptor responses. They control GABA-B signaling and regulate the rise time and duration of G protein-coupled inwardly rectifying potassium (GIRK) currents, as well as enhance receptor expression levels. KCTD12 regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. Members of this family consist of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


Pssm-ID: 409026  Cd Length: 118  Bit Score: 222.46  E-value: 1.09e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 206 SGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDR-QPEKYTSRFYLKFTYLEQAFDRLS 284
Cdd:cd22204   1 PGYITLGYRGTFAFGRDGQADVKFRKLARILVCGKVSLCREVFGDTLNESRDPDRgEPDRYTSRFFLKHNYLEQAFDQLA 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 38198663 285 EAGFHMVACNSSGTAAFV-NQYRDDKIWSSYTEYIFFR 321
Cdd:cd22204  81 EAGFRLVASCGSGTSGLPsAGDSEEKRWNHYTEFVFVR 118
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-150 3.68e-65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 205.04  E-value: 3.68e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18396   2 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSR-------RAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALP 74

                        90       100
                ....*....|....*....|....*....
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSPKV 150
Cdd:cd18396  75 DHFPEKERLLREAEYFQLGDLVKLLTPKV 103
H1_KCTD12 cd22217
H1 domain found in potassium channel tetramerization domain-containing protein 12; Potassium ...
 205-321 8.52e-65

H1 domain found in potassium channel tetramerization domain-containing protein 12; Potassium channel tetramerization domain-containing protein 12 (KCTD12), also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors associated with mood disorders. It regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. KCTD12 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


Pssm-ID: 409028  Cd Length: 119  Bit Score: 204.86  E-value: 8.52e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663 205 RSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLS 284
Cdd:cd22217   1 RSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLS 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 38198663 285 EAGFHMVACNSSGTAAFV-NQYRDDKIWSSYTEYIFFR 321
Cdd:cd22217  81 ESGFHMVACSSTGTCAFAsTDQSEDKIWTSYTEYVFCR 118
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-148 1.01e-62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 198.67  E-value: 1.01e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18367   1 FPEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSG-------KNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLP 73

                        90       100
                ....*....|....*....|....*..
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSP 148
Cdd:cd18367  74 ENFPERERLKREAEYFQLPELVKALRA 100
BTB_POZ_KCTD16 cd18398
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-148 5.59e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349706 [Multi-domain]  Cd Length: 103  Bit Score: 165.86  E-value: 5.59e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGarrrgELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18398   1 FPEVVELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDTAN-----DLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLP 75

                        90       100
                ....*....|....*....|....*..
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSP 148
Cdd:cd18398  76 DHFPEKGRLKREAEYFQLPDLVKLLTP 102
BTB_POZ_KCTD12_Pfetin cd18397
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-148 9.21e-50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349705 [Multi-domain]  Cd Length: 100  Bit Score: 165.06  E-value: 9.21e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18397   1 FPEIVELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKP-------GELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLP 73

                        90       100
                ....*....|....*....|....*..
gi 38198663 122 EHFPEKERLLREAEYFQLTDLVKLLSP 148
Cdd:cd18397  74 DYFPERSRLQREAEFFQLPELVKRLNP 100
BTB_POZ_KCTD6_like cd18365
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-146 3.40e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349674 [Multi-domain]  Cd Length: 94  Bit Score: 112.87  E-value: 3.40e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgeLPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18365   1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMP---------TTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPED 71

                        90       100
                ....*....|....*....|...
gi 38198663 124 FPEKERLLREAEYFQLTDLVKLL 146
Cdd:cd18365  72 FKEYDLLLREADFYQIEPLIEAL 94
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-137 2.37e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 109.95  E-value: 2.37e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFS---------GRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFV 71

                        90
                ....*....|..
gi 38198663 126 EKERLLREAEYF 137
Cdd:cd18316  72 ELEELLAEAEFY 83
BTB_POZ_KCTD6 cd18394
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-149 8.78e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349702 [Multi-domain]  Cd Length: 104  Bit Score: 101.19  E-value: 8.78e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFspssprggarrRGELP--RDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18394   5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMF-----------RGDFPtaRDSQGNYFIDRDGPLFRYILNFLRTSELTLPVD 73

                        90       100
                ....*....|....*....|....*..
gi 38198663 124 FPEKERLLREAEYFQLTDLVKLLS-PK 149
Cdd:cd18394  74 FKEFDLLRKEADFYQIEPLIQCLNdPK 100
BTB_POZ_KCTD7 cd18366
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-143 1.53e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349675  Cd Length: 92  Bit Score: 99.69  E-value: 1.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  42 FPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLalp 121
Cdd:cd18366   2 FPEVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSG---------RHHIPKDSEGRYFIDRDGSYFGYILNFLRDGDL--- 69

                        90       100
                ....*....|....*....|....*
gi 38198663 122 ehfPEKERLL---REAEYFQLTDLV 143
Cdd:cd18366  70 ---PPRERARavyKEAQYYGIGPLI 91
BTB_POZ_KCTD4 cd18364
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-139 8.11e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349673 [Multi-domain]  Cd Length: 86  Bit Score: 97.83  E-value: 8.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  45 VVELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYPDSFLEGMVN---------GKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGF 71

                        90
                ....*....|....*
gi 38198663 125 PEKERLLREAEYFQL 139
Cdd:cd18364  72 QENQLLALEADFYQL 86
BTB_POZ_KCTD21 cd18395
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-149 2.36e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349703 [Multi-domain]  Cd Length: 98  Bit Score: 96.93  E-value: 2.36e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRggarrrgelPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFPT---------KKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQ 73

                        90       100
                ....*....|....*....|....
gi 38198663 126 EKERLLREAEYFQLTDLVKLLSPK 149
Cdd:cd18395  74 EMGLLKREADFYQIQPLIEALQEK 97
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-148 1.98e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 94.03  E-value: 1.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGgarrrgelpRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18375   1 ELVTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKDQDF---------KVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTE 71

                        90       100
                ....*....|....*....|....*
gi 38198663 124 FPEKERLLREAEYFQLTDLVKLLSP 148
Cdd:cd18375  72 FSDYNRLAREAEFYGLYSLADLLSQ 96
BTB_POZ_KCTD14 cd18371
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-150 1.27e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349680  Cd Length: 99  Bit Score: 92.12  E-value: 1.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  43 PEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSpSSPRggarrrgeLPRDSRARFFIDRDGFLFRYVLDYLRDKQLAlPE 122
Cdd:cd18371   1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELFN-GQPK--------LRTDSEGRYFIDRDGTYFRYILEYLRTNQVP-TQ 70

                        90       100       110
                ....*....|....*....|....*....|
gi 38198663 123 HFPEkerLLREAEYFQLTDLVKLL--SPKV 150
Cdd:cd18371  71 HIQE---VYKEALFYDIEPLVKLLeeSPQI 97
BTB_POZ_FIP2-like cd18376
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-142 1.55e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349685  Cd Length: 89  Bit Score: 91.54  E-value: 1.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarRRGELPRDSRARFFIDRDGFLFRYVLDYLRD-KQLALPEHF 124
Cdd:cd18376   1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFS---------GRHSLKKDEDGSYFIDRDGTHFRHILNYLRDgEVKIPTEDR 71

                        90
                ....*....|....*...
gi 38198663 125 PEKERLLREAEYFQLTDL 142
Cdd:cd18376  72 SVLKELLEEAEYYQLRGL 89
BTB_POZ_KCTD1-like cd18361
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-146 3.63e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349670  Cd Length: 94  Bit Score: 90.51  E-value: 3.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgeLPRDS-RARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIP---------IVLDSlKQHYFIDRDGKMFRHILNFLRTSKLLLPDDF 71

                        90       100
                ....*....|....*....|..
gi 38198663 125 PEKERLLREAEYFQLTDLVKLL 146
Cdd:cd18361  72 TEFDLLYEEARYYELQPMVKQL 93
BTB_POZ_KCTD11 cd18370
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-138 3.98e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.


Pssm-ID: 349679  Cd Length: 88  Bit Score: 84.67  E-value: 3.98e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFspsspRGGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRFPDSMLGAMF-----RAGTPIPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYG 75

                        90
                ....*....|...
gi 38198663 126 EKERLLREAEYFQ 138
Cdd:cd18370  76 ETALLRAEADFYQ 88
BTB_POZ_KCTD15 cd18388
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-146 3.23e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.


Pssm-ID: 349696  Cd Length: 99  Bit Score: 76.96  E-value: 3.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgeLPRDS-RARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18388   4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEP---------IVLDSlKQHYFIDRDGEIFRYILSFLRTSKLLLPEDF 74

                        90       100
                ....*....|....*....|..
gi 38198663 125 PEKERLLREAEYFQLTDLVKLL 146
Cdd:cd18388  75 KDFNLLYEEAKYYQLQPMVKEL 96
BTB_POZ_KCTD10-like_BACURD cd18369
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-144 5.66e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349678 [Multi-domain]  Cd Length: 91  Bit Score: 70.11  E-value: 5.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSvPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18369   1 VKLNVGGSLHYTTIGTLTK-QDTMLRAMFSG---------RMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRR 70

                        90
                ....*....|....*....
gi 38198663 126 EKERLLREAEYFQLTDLVK 144
Cdd:cd18369  71 ELAELLAEAKYYLVQGLVE 89
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-150 7.51e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 69.98  E-value: 7.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLS-VPDSTLASMFSPSSPRGGARrrgelprDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18368   3 IKLNVGGRIFTTTRSTLVKkEPDSMLARMFSDDSTWPSSR-------DENGAYLIDRSPEYFEPILNYLRHGQLILNDGL 75

                        90       100
                ....*....|....*....|....*.
gi 38198663 125 pEKERLLREAEYFQLTDLVKLLSPKV 150
Cdd:cd18368  76 -NPLGVLEEAKFFGIQSLIEILEQLI 100
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 46-142 8.18e-15

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 69.93  E-value: 8.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663    46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarRRGELPRDSRARFFIDRDGFLFRYVLDYLRDK-QLALPEHF 124
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLE---------LECDDYDDDTNEYFFDRSPKHFETILNFYRTGgKLHRPEEV 71

                          90
                  ....*....|....*...
gi 38198663   125 PEKErLLREAEYFQLTDL 142
Cdd:pfam02214  72 CLDE-FLEEAEFYGLDEL 88
BTB_POZ_KCTD3-like cd18363
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-137 6.69e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349672  Cd Length: 86  Bit Score: 67.01  E-value: 6.69e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarrrGELP--RDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18363   2 DIINLNVGGKRFSTSRQTLTWIPDSFFTSLLS-----------GRISslKDETGAIFIDRDPKLFSIILNYLRTKEIDLR 70

                        90
                ....*....|....*.
gi 38198663 122 EhfPEKERLLREAEYF 137
Cdd:cd18363  71 N--VDISSLRHEAEFY 84
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-142 2.34e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349695  Cd Length: 105  Bit Score: 66.18  E-value: 2.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgeLPRDS-RARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18387   5 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEP---------IVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDF 75

                        90
                ....*....|....*...
gi 38198663 125 PEKERLLREAEYFQLTDL 142
Cdd:cd18387  76 KDYSLLYEEAKYFQLQPM 93
BTB_POZ_KCTD13_BACURD1 cd18400
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-144 3.23e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349708  Cd Length: 103  Bit Score: 65.73  E-value: 3.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLlSVPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18400   4 VKLNVGGSLHYTTVQTL-TKQDTMLKAMFSG---------RVEVLTDSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTR 73

                        90
                ....*....|....*....
gi 38198663 126 EKERLLREAEYFQLTDLVK 144
Cdd:cd18400  74 ELEELLGEARYYLVQGLVE 92
BTB_POZ_TNFAIP1_BACURD2 cd18401
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-168 1.20e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349709  Cd Length: 104  Bit Score: 64.13  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKhSTLLSVPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18401   5 VRLNVGGSLYYTT-VQVLTRHDTMLKAMFSG---------RMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQ 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 38198663 126 EKERLLREAEYFQLTDLVKLlspkvtkqnslndegCQSDLEDN 168
Cdd:cd18401  75 EIKELMAEAKYYLIQGLVDM---------------CQAALQDK 102
BTB_POZ_KCTD18 cd18372
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-137 1.53e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349681  Cd Length: 101  Bit Score: 63.67  E-value: 1.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgeLPRDSRARFFIDRDGFLFRYVLDYLRDkQLALPEH 123
Cdd:cd18372   1 DVLRLNVGGCIYTARRESLCRFKDSMLSSMFSGRFP---------LKLDESGACVIDRDGRLFKYLLDYLHG-ELQIPED 70

                        90
                ....*....|....
gi 38198663 124 FPEKERLLREAEYF 137
Cdd:cd18372  71 EQTRLALQEEADYF 84
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-136 1.93e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 59.93  E-value: 1.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMfspssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKL----------AKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVC 70

                        90
                ....*....|.
gi 38198663 126 EkERLLREAEY 136
Cdd:cd18317  71 P-ASFKEELEF 80
BTB_POZ_KCTD10_BACURD3 cd18399
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-144 1.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349707  Cd Length: 110  Bit Score: 58.54  E-value: 1.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLlSVPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18399   9 VKLNVGGALYYTTMQTL-TKQDTMLKAMFSG---------RMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRR 78

                        90
                ....*....|....*....
gi 38198663 126 EKERLLREAEYFQLTDLVK 144
Cdd:cd18399  79 EIEELLAEAKYYLVQGLVE 97
BTB_POZ_SHKBP1 cd18393
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-146 3.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349701  Cd Length: 103  Bit Score: 57.25  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggarrrGELP--RDSRARFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18393   2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLS-----------GRIStlKDETGAIFIDRDPTVFAPILNFLRTKELDPR 70

                        90       100
                ....*....|....*....|....*
gi 38198663 122 EhfPEKERLLREAEYFQLTDLVKLL 146
Cdd:cd18393  71 G--IHVSLLLHEAQFYGITPLVRRL 93
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-153 1.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 55.00  E-value: 1.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGarrrgelpRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSD--------RDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMA 74

                        90       100
                ....*....|....*....|....*...
gi 38198663 126 EkERLLREAEYFQLTDLVKLLSPKVTKQ 153
Cdd:cd18391  75 E-EGVLEEAEFYNIGPLIRIIKDRMEEK 101
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-137 3.47e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 53.63  E-value: 3.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSsprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPG--------REFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGIS 72

                        90
                ....*....|..
gi 38198663 126 EkERLLREAEYF 137
Cdd:cd18187  73 I-PDLREECDFY 83
BTB_POZ_KCTD3 cd18392
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-140 3.98e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349700  Cd Length: 88  Bit Score: 53.33  E-value: 3.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALpeH 123
Cdd:cd18392   2 EIIQLNVGGTRFSTSRQTLMWIPDSFFSSLLSG---------RISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL--R 70

                        90
                ....*....|....*..
gi 38198663 124 FPEKERLLREAEYFQLT 140
Cdd:cd18392  71 GVNINVLRHEAEFYGIT 87
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 46-145 5.83e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 5.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663     46 VELNVGGQVYVTkHSTLLSVPDSTLASMFSpssprggarrRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHfp 125
Cdd:smart00225   2 VTLVVGGKKFHA-HKAVLAAHSPYFKALFS----------SDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-- 68

                           90       100
                   ....*....|....*....|
gi 38198663    126 EKERLLREAEYFQLTDLVKL 145
Cdd:smart00225  69 NVEELLELADYLQIPGLVEL 88
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-155 1.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 53.07  E-value: 1.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSpssprggARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18390   7 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQ-------ADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLA 79

                        90       100       110
                ....*....|....*....|....*....|
gi 38198663 126 EkERLLREAEYFQLTDLVKLLSPKVTKQNS 155
Cdd:cd18390  80 E-EGVLEEAEFYNITSLIKLVKDKIRERDS 108
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-150 2.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 51.91  E-value: 2.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGarrrgelPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEHFP 125
Cdd:cd18389   3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPDLDS-------DKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELA 75

                        90       100
                ....*....|....*....|....*
gi 38198663 126 EkERLLREAEYFQLTDLVKLLSPKV 150
Cdd:cd18389  76 E-EGVLEEAEFYNIASLVRLVKERI 99
BTB_POZ_KCTD2-like cd18362
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-137 3.90e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.


Pssm-ID: 349671 [Multi-domain]  Cd Length: 85  Bit Score: 50.44  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSprggarrrgELP--RDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18362   2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDP---------DLPsdKDETGAYLIDRDPTYFGPILNYLRHGKLIIDKD 72

                        90
                ....*....|....
gi 38198663 124 FPEkERLLREAEYF 137
Cdd:cd18362  73 LAE-EGVLEEAEFY 85
BTB1_POZ_KCTD19 cd18373
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 49-146 8.45e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349682  Cd Length: 98  Bit Score: 47.08  E-value: 8.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  49 NVGGQVYVTKHSTLLSVPDSTLAsmfspssprggaRRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALpEHFPEKE 128
Cdd:cd18373   4 NVGGWIFSVPKSKLAQFPDSLLW------------KEASSLSESENTRLFIDRDGFTFRHVHYYLQTSKLSS-SSCSELN 70

                        90
                ....*....|....*...
gi 38198663 129 RLLREAEYFQLTDLVKLL 146
Cdd:cd18373  71 LLYEQAAGLQLTSLLQAL 88
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-121 1.80e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 46.62  E-value: 1.80e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38198663  46 VELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrgELPRDSRAR-FFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEAS--------AFDYDPVTGeFFFDRHPGVFAQILNYYRTGKLHCP 69
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-128 1.94e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 46.21  E-value: 1.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  48 LNVGGQVYVTKHSTLLSVPDSTLasmfspssprgGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLalpeHFPEK 127
Cdd:cd18380   4 INVSGRRFETWKNTLEKYPDTLL-----------GSTEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKL----HYPRH 68


                .
gi 38198663 128 E 128
Cdd:cd18380  69 E 69
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-121 9.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 44.77  E-value: 9.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGELPRDSRA-----RFFIDRDGFLFRYVLDYLRDKQL 118
Cdd:cd18415   2 ERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSpgggnEFFFDRHPGVFAYVLNYYRTGKL 81


                ...
gi 38198663 119 ALP 121
Cdd:cd18415  82 HCP 84
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-121 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 43.79  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  43 PEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPrggarrrGELPRDSRA-RFFIDRDGFLFRYVLDYLRDKQLALP 121
Cdd:cd18414   2 SDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAH-------SNFDYDPRAdEFFFDRHPGVFAHILNYYRTGKLHCP 74
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-123 9.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 42.53  E-value: 9.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLasmfspssprgGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18420  36 EKLIINVSGRRFETWRNTLEKYPDTLL-----------GSNEREFFYDEETKEYFFDRDPDIFRHILNYYRTGKLHYPKH 104
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-123 1.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 41.10  E-value: 1.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38198663  45 VVELNVGGQVYVTKHSTLLSVPDSTLasmfspssprgGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18418   1 LIVLNVSGTRFQTWRNTLERYPDTLL-----------GSSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRH 68
BTB2_POZ_KCTD19 cd18374
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-146 1.50e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349683  Cd Length: 99  Bit Score: 40.95  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDStlasmfspssprggarrrgeLPRDSRARF-------FIDRDGFLFRYVLDYLRDK 116
Cdd:cd18374   1 QIVKVYVGSHWYATYLKTLLKYPEL--------------------LSNSKKVRWitygqtlLISGDGQMFRHILNFLRLG 60

                        90       100       110
                ....*....|....*....|....*....|
gi 38198663 117 QLALPEHFPEKERLLREAEYFQLTDLVKLL 146
Cdd:cd18374  61 KLLLPSEFKEWPLLCQEVEEYQIPALSEAL 90
BTB_POZ_KCNA7 cd18408
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-137 3.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349715  Cd Length: 115  Bit Score: 40.30  E-value: 3.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLasmfspssprGGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRD-KQLALPE 122
Cdd:cd18408   6 ERVVLNVAGLRFETRARTLGRFPDTLL----------GDPARRGRFYDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRPA 75

                        90       100       110
                ....*....|....*....|....*....|
gi 38198663 123 HFP---------------EKERLLREAEYF 137
Cdd:cd18408  76 HVPldvfleevafyglgaAALARLREDEGC 105
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-123 5.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 39.96  E-value: 5.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLasmfspssprgGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18419  35 ELIVLNVSGRRFQTWRTTLERYPDTLL-----------GSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRY 103
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-123 2.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 38.39  E-value: 2.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  44 EVVELNVGGQVYVTKHSTLLSVPDSTLasmfspssprGGARRRGELPRDSRARFFiDRDGFLFRYVLDYLRDKQLALPEH 123
Cdd:cd18417  35 EILVVNVSGRRFQTWKNTLDRYPDTLL----------GSSEKEFFYNEDTQEYFF-DRDPEMFRHILNFYRTGRLHYPRH 103
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-142 4.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 37.10  E-value: 4.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38198663  48 LNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRggarrRGELPRDSR---ARFFIDRDGFLFRYVLDYLRDKQLALPEHF 124
Cdd:cd18424   3 INVGGSRFVLSQQVLSSHPETRLGKLAVSVRDS-----VLELCDDANfvdNEYFFDRSSQAFKYIMNYYKTGHLHVMEEL 77

                        90
                ....*....|....*...
gi 38198663 125 PEKErLLREAEYFQLTDL 142
Cdd:cd18424  78 CAIS-FLQEIEYWGIDEL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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