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Conserved domains on  [gi|1566185500|ref|NP_899197|]
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solute carrier family 12 member 1 isoform A [Mus musculus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1090 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1523.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSI 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  252 GLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIA 330
Cdd:TIGR00930  162 GLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSIL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  331 NFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 409
Cdd:TIGR00930  242 NIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  410 IFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITA 489
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  490 GIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLAS 569
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  570 YALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQAL 649
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  650 SYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAW 729
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  730 LIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQG 809
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  810 FDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagklnitKPAPKKDGNISSIQSMHvgefnqklVEA 889
Cdd:TIGR00930  713 LPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LEA 750
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  890 SAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIG 968
Cdd:TIGR00930  751 STQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLM 830
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  969 DINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLS 1047
Cdd:TIGR00930  831 DINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLS 910
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|...
gi 1566185500 1048 LPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1090
Cdd:TIGR00930  911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1090 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1523.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSI 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  252 GLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIA 330
Cdd:TIGR00930  162 GLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSIL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  331 NFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 409
Cdd:TIGR00930  242 NIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  410 IFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITA 489
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  490 GIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLAS 569
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  570 YALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQAL 649
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  650 SYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAW 729
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  730 LIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQG 809
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  810 FDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagklnitKPAPKKDGNISSIQSMHvgefnqklVEA 889
Cdd:TIGR00930  713 LPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LEA 750
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  890 SAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIG 968
Cdd:TIGR00930  751 STQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLM 830
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  969 DINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLS 1047
Cdd:TIGR00930  831 DINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLS 910
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|...
gi 1566185500 1048 LPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1090
Cdd:TIGR00930  911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
685-1090 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 604.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  685 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 764
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  765 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELE-KLEQERLALEAAIKDNECEE 843
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEElGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  844 GKGGIRGLFKKAGKLN--------ITKPAPKKDGNISSIQSMHVGEF--------NQKLVEASAQFKKKQGKGTIDVWWL 907
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDsnlslspdKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  908 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMI 986
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  987 EPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1066
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1566185500 1067 ILTKNLPPVLLVRGNHKNVLTFYS 1090
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
181-640 3.48e-38

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 148.89  E-value: 3.48e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  181 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 260
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  261 VAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvips 340
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  341 nnekksrGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGV 420
Cdd:COG0531    169 -------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  421 AICVAACVVRDATGSMNDTIvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 498
Cdd:COG0531    241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  499 ALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYALINFS 576
Cdd:COG0531    288 LNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1566185500  577 CFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 640
Cdd:COG0531    366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1090 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1523.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSI 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSI 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  252 GLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIA 330
Cdd:TIGR00930  162 GLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSIL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  331 NFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 409
Cdd:TIGR00930  242 NIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  410 IFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITA 489
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  490 GIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLAS 569
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  570 YALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQAL 649
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  650 SYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAW 729
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  730 LIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQG 809
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  810 FDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagklnitKPAPKKDGNISSIQSMHvgefnqklVEA 889
Cdd:TIGR00930  713 LPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LEA 750
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  890 SAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIG 968
Cdd:TIGR00930  751 STQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLM 830
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  969 DINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLS 1047
Cdd:TIGR00930  831 DINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLS 910
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|...
gi 1566185500 1048 LPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1090
Cdd:TIGR00930  911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
685-1090 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 604.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  685 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 764
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  765 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELE-KLEQERLALEAAIKDNECEE 843
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEElGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  844 GKGGIRGLFKKAGKLN--------ITKPAPKKDGNISSIQSMHVGEF--------NQKLVEASAQFKKKQGKGTIDVWWL 907
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDsnlslspdKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  908 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMI 986
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  987 EPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1066
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1566185500 1067 ILTKNLPPVLLVRGNHKNVLTFYS 1090
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
173-676 1.59e-126

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 394.38  E-value: 1.59e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  173 GVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGSIG 252
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  253 L------IFAFANAVAVAMYVVGFAETVVDLLKESdsmmvdptndirIIGSITVVILLGISVAGMEWEAKAQVILLVILL 326
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  327 IAIANFFIGTVIPSNNEKKSRG--FFNYQASIFAENFGPSFTKGegFFSVFAIFFPAATGILAGANISGDLEDPQDAIPR 404
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG--FISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPK 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  405 GTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmncngsaacglgydfsrcqhepcqYGLMNNFQVMSMVSGFG 484
Cdd:pfam00324  226 AILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLA 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  485 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKglqFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNviAPIISN 564
Cdd:pfam00324  281 PLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLN--PAIVFN 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  565 FFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGS 644
Cdd:pfam00324  356 FLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGA 435
                          490       500       510
                   ....*....|....*....|....*....|..
gi 1566185500  645 STQALSYVSALDNALELTTVEDHVKNFRPQCI 676
Cdd:pfam00324  436 GSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
181-640 3.48e-38

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 148.89  E-value: 3.48e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  181 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 260
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  261 VAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvips 340
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  341 nnekksrGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGV 420
Cdd:COG0531    169 -------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  421 AICVAACVVRDATGSMNDTIvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 498
Cdd:COG0531    241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  499 ALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYALINFS 576
Cdd:COG0531    288 LNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1566185500  577 CFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 640
Cdd:COG0531    366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
86-148 1.54e-29

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 112.15  E-value: 1.54e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500   86 DSHTNTYYLQ-----TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVT--VAPGSADRVANGDG 148
Cdd:pfam08403    1 DTHGSTYYLQtfghnTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSAlaVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
198-620 1.14e-16

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 83.90  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  198 AGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDL 277
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  278 LKESdsmMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPsnneKKSRGFFNYqASIF 357
Cdd:pfam13520  107 LGPD---LVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNL-LSGE 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  358 AENFGPSFTKGegFFSVFAIFFPAATGILAGANISGdlEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMN 437
Cdd:pfam13520  179 WHTFFPDGWPG--VFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALSS 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  438 DTIVSGmncngsaacglgydfsrcqhepcqyGLMNNFQVMSMVSGFgplITAGIFSATLSSALASLVSAPKVFQALCKDN 517
Cdd:pfam13520  255 GLGQVA-------------------------ALLFQAVGGKWGAII---VVILLALSLLGAVNTAIVGASRLLYALARDG 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566185500  518 IFKGLQFFAKgYGKNNEPLRGYFLTFVIAMAFILI-----AELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRpay 592
Cdd:pfam13520  307 VLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLfllspAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGR--- 382
                          410       420
                   ....*....|....*....|....*...
gi 1566185500  593 gIYNMWVSLFGAILCCAVMFVINWWAAV 620
Cdd:pfam13520  383 -IPGRWPVAIFGILFSLFLIVALFFPPV 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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