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Conserved domains on  [gi|34335134|ref|NP_899195|]
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protein SEC13 homolog isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.69e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 2.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 185 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLW---DLATGELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 34335134 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.69e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 2.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 185 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLW---DLATGELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 34335134 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.44e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 89
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  90 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200  82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 165 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200 147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 34335134 244 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200 205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 4.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.10e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 34335134     49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134   11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 34335134   84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
202-243 6.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 6.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 34335134   202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.69e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 2.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 105 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 184
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 185 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 262
Cdd:COG2319 264 GSADGTVRLW---DLATGELLRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTgh 329

                       250       260
                ....*....|....*....|....*...
gi 34335134 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 330 tGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 6.42e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 6.42e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 105 SVNSVCWAPHdyGLILACGSSDGAISLLTYTGegqWEVKKINNAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFAS 184
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAF-----------SPDG------KLLAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 185 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 262
Cdd:COG2319 306 GSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW-------DLATGELLRTLTgh 371

                       250       260
                ....*....|....*....|....*...
gi 34335134 263 -DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 372 tGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
10-289 6.54e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 6.54e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 89
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  90 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWApavvpgsli 168
Cdd:COG2319 151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFS--------- 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 169 dhPSGQkpnyikRFASGGCDNLIKLWKEEedgQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 248
Cdd:COG2319 214 --PDGK------LLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 34335134 249 SSNTWsPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.44e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 89
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  90 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200  82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 165 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200 147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 34335134 244 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200 205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-290 6.85e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 6.85e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134   7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 86
Cdd:cd00200  45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  87 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWapa 161
Cdd:cd00200 121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAF--- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 162 vvpgslidHPSGqkpnyiKRFASGGCDNLIKLWkEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 241
Cdd:cd00200 186 --------SPDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 34335134 242 IWtcddassNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 290
Cdd:cd00200 245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.18e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 104
Cdd:COG2319  48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 105 SVNSVCWAPHdyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFA 183
Cdd:COG2319 122 AVRSVAFSPD--GKTLASGSADGTVRLWdLATGKLLRTLT----GHSGAVTSVAF-----------SPDG------KLLA 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134 184 SGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDASSNTWsPKLLHKFND 263
Cdd:COG2319 179 SGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD-G---KLLASGSADGTVRLW---DLATGKL-LRTLTGHSG 247

                       250       260
                ....*....|....*....|....*.
gi 34335134 264 VVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
10-87 1.55e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.55e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34335134  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 87
Cdd:COG2319 327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 4.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.10e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 34335134     49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335134   11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 34335134   84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-243 1.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 34335134    201 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
202-243 6.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 6.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 34335134   202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
49-86 6.92e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 6.92e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 34335134    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 3.67e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 3.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 34335134     92 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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