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Conserved domains on  [gi|33624896|ref|NP_891550|]
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A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 3.94e-116

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 365.79  E-value: 3.94e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ 371
Cdd:cd04273    1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  372 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 447
Cdd:cd04273   81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 33624896  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273  161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1736-1934 1.88e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 352.30  E-value: 1.88e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1736 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1815
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1816 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1894
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 33624896   1895 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1934
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.65e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.65e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896     49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33624896    129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 4.75e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.75e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    754 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 33624896    833 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 7.05e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 7.05e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    511 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 1.20e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 81.35  E-value: 1.20e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1386-1439 7.58e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 7.58e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1439
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1559-1612 2.55e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.55e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1559 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1332-1383 4.32e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 4.32e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1332 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1383
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 7.71e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.83  E-value: 7.71e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896     591 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1501-1554 5.99e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 5.99e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1501 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1554
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 6.61e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.61e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1056 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1445-1498 6.80e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.80e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1498
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 7.15e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.15e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 2.90e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 59.34  E-value: 2.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    648 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 33624896    718 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 5.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 5.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1186 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 6.98e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1681-1729 8.06e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 8.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33624896   1681 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1729
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1616-1675 2.30e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.30e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33624896   1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1675
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 2.36e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 2.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33624896    885 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 1.89e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    939 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 3.94e-116

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 365.79  E-value: 3.94e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ 371
Cdd:cd04273    1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  372 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 447
Cdd:cd04273   81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 33624896  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273  161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1736-1934 1.88e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 352.30  E-value: 1.88e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1736 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1815
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1816 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1894
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 33624896   1895 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1934
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.65e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.65e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896     49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33624896    129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 4.75e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.75e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    754 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 33624896    833 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-499 2.74e-33

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 128.19  E-value: 2.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    293 RFVEVLVVADNRMVSYHGENLQH---YILTLMSIVASIYKDpsignlINI-VIVNLIVIHNEQDGPSISFNAQTTLKNFC 368
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIrVVLVGLEIWTDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    369 QWQHSkNSPGGIHHDTAVLLTRQDIcrahdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHD 445
Cdd:pfam01421   75 KWRQE-YLKKRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQHD 148

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 33624896    446 DNN---KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 499
Cdd:pfam01421  149 DFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 7.05e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 7.05e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    511 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 1.20e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 81.35  E-value: 1.20e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1386-1439 7.58e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 7.58e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1439
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1559-1612 2.55e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.55e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1559 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1332-1383 4.32e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 4.32e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1332 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1383
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 7.71e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.83  E-value: 7.71e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896     591 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1501-1554 5.99e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 5.99e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1501 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1554
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 6.61e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.61e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1056 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1445-1498 6.80e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.80e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1498
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 7.15e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.15e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 2.90e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 59.34  E-value: 2.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    648 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 33624896    718 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 5.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 5.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1186 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 6.98e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1681-1729 8.06e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 8.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33624896   1681 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1729
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1616-1675 2.30e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.30e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33624896   1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1675
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 592-642 4.92e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 4.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 33624896    592 GSWSPFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 642
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1239-1296 1.74e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 1.74e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 33624896    1239 CGQWKalDWSSCSVTCGQGRATRQVMCVNYSDHViDRSECDQDYiPETdQDCSMSPCP 1296
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1001-1054 2.04e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 2.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVTIQRCSEFPCP 1054
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1199-1317 2.31e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  1199 GKGTRMRY----VSCRDENG-----SVADESACATLPRPVAKEECS----VTPCGQWKalDWSSCSVTCGQGRATRQ--V 1263
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 33624896  1264 MCVNYSDHVIdrSECDQDyipetdqDCSMSPCPQRTPDsglaQHPFQNEDYRPR 1317
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPA----PVPPTPEDDNPR 305
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 2.36e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 2.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33624896    885 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1186-1239 4.10e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 4.10e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVaDESACATLPRpvAKEECSVTPC 1239
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1562-1613 5.09e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 5.09e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1562 EEWQECTKTCGEGSRYRKVVCVdDNKNEVHGARCDVSKRpvDRESCSLQPCE 1613
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1059-1103 1.25e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 33624896    1059 GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC---DPETKPTSMQTC 1103
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCtgeDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1386-1440 1.40e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.40e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    1386 WAYGNWGECTKLCGGGIRTRLVVCQrSNGERFPDLSCEILDkpPDREQCNTHACP 1440
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1332-1384 4.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 4.61e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1384
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1445-1499 5.34e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 5.34e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDyCKHLAKPhgHRKCRGGRCP 1499
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP-CTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1504-1555 9.55e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.55e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1504 GAWSQCSVSCGRGVQQRHVGCqIGTHKIARETECNPYTRpeSERDCQGPRCP 1555
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 1.89e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    939 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1615-1676 2.85e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.85e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1615 VWITGEWSECSVTCGKGYKQRLVSCseiytgkeNYEYSYQTTINCPGtQPPSVHPCYLRDCP 1676
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC--------CSPPPQNGGGPCTG-EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1114-1166 6.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 6.58e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 33624896    1114 GPWGQCSVTCGQGYQLRAVKCIIGTymSVVDDNDCNAATRptDTQDCELPSCH 1166
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-496 3.94e-116

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 365.79  E-value: 3.94e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ 371
Cdd:cd04273    1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  372 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 447
Cdd:cd04273   81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 33624896  448 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Cdd:cd04273  161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1736-1934 1.88e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 352.30  E-value: 1.88e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1736 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1815
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896   1816 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1894
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 33624896   1895 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1934
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 293-488 1.27e-70

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 235.01  E-value: 1.27e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMVSY---HGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQ 369
Cdd:cd04267    1 REIELVVVADHRMVSYfnsDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  370 WQHSknspGGIHHDTAVLLTRQDIcrahDKCDTLGLAELGTICDPYRSCSISEDSG--LSTAFTIAHELGHVFNMPHDDN 447
Cdd:cd04267   81 WRAE----GPIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEHDGG 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 33624896  448 NKCKEEGVKSPQHVMAPTLNFyTNPWMWSKCSRKYITEFLD 488
Cdd:cd04267  153 DELAFECDGGGNYIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 293-497 1.13e-39

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 146.61  E-value: 1.13e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMVSYHGENL---QHYILTLMSIVASIYKDpsignlINI-VIVNLIVIHNEQDGPSISFNAQTTLKNFC 368
Cdd:cd04269    1 KYVELVVVVDNSLYKKYGSNLskvRQRVIEIVNIVDSIYRP------LNIrVVLVGLEIWTDKDKISVSGDAGETLNRFL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  369 QWQHSKNSPGgIHHDTAVLLTRQDICRahdkcDTLGLAELGTICDPYRSCSISEDSG---LSTAFTIAHELGHVFNMPHD 445
Cdd:cd04269   75 DWKRSNLLPR-KPHDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGMEHD 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 33624896  446 DNN-KCKEEGVkspqhVMAPTLNFYTnpWMWSKCSRKYITEFLDTGYGECLLN 497
Cdd:cd04269  149 DGGcTCGRSTC-----IMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.65e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.65e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896     49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33624896    129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 754-871 4.75e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.75e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    754 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 832
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 33624896    833 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 871
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-499 2.74e-33

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 128.19  E-value: 2.74e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    293 RFVEVLVVADNRMVSYHGENLQH---YILTLMSIVASIYKDpsignlINI-VIVNLIVIHNEQDGPSISFNAQTTLKNFC 368
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKE------LNIrVVLVGLEIWTDEDKIDVSGDANDTLRNFL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    369 QWQHSkNSPGGIHHDTAVLLTRQDIcrahdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHD 445
Cdd:pfam01421   75 KWRQE-YLKKRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQHD 148

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 33624896    446 DNN---KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 499
Cdd:pfam01421  149 DFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 293-487 1.64e-31

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 121.86  E-value: 1.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  293 RFVEVLVVADNRMvsYHGENLQHYILTLMSIVASIYKDPsigNLINIVIVNLIVIHneqdgpsisfnaqttlknfcqwqh 372
Cdd:cd00203    1 KVIPYVVVADDRD--VEEENLSAQIQSLILIAMQIWRDY---LNIRFVLVGVEIDK------------------------ 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  373 sknspggihHDTAVLLTRQDIcrahdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHDDNNK 449
Cdd:cd00203   52 ---------ADIAILVTRQDF-----DGGTGGWAYLGRVCDSLRGVGVLQDNQSGTkegAQTIAHELGHALGFYHDHDRK 117

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 33624896  450 CKEEGVKS----------PQHVMAPTLNFYT--NPWMWSKCSRKYITEFL 487
Cdd:cd00203  118 DRDDYPTIddtlnaedddYYSVMSYTKGSFSdgQRKDFSQCDIDQINKLY 167
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 511-578 7.05e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.39  E-value: 7.05e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    511 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 578
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1111-1165 1.20e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 81.35  E-value: 1.20e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 294-495 2.71e-14

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 73.93  E-value: 2.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  294 FVEVLVVADNRMVSYHGENLQ--HYILTLMSIVASIYKDPSIGNlINIVIVNLIVIHNEQDGPSI------SFNAQTTLK 365
Cdd:cd04272    2 YPELFVVVDYDHQSEFFSNEQliRYLAVMVNAANLRYRDLKSPR-IRLLLVGITISKDPDFEPYIhpinygYIDAAETLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  366 NFCQWQHSKNSPGgiHHDTAVLLTRQDICRAHD-KCDT--LGLAELGTICDPYRsCSISEDSGLS--TAFTIAHELGHVF 440
Cdd:cd04272   81 NFNEYVKKKRDYF--NPDVVFLVTGLDMSTYSGgSLQTgtGGYAYVGGACTENR-VAMGEDTPGSyyGVYTMTHELAHLL 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33624896  441 NMPHDD---NNKCK----------EEGvkspqHVMApTLNFYTNPWMWSKCSRKYITEFLDTGYGECL 495
Cdd:cd04272  158 GAPHDGsppPSWVKghpgsldcpwDDG-----YIMS-YVVNGERQYRFSQCSQRQIRNVFRRLGASCL 219
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1386-1439 7.58e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 7.58e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1439
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
291-473 1.07e-12

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 68.60  E-value: 1.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    291 YPRFVEVLVVADNRMVSYH-GENLQHYILTLMSIVASIYKDPSigNlINIVIVNLIvIHNEQDGPSISF----NAQTTLK 365
Cdd:pfam13688    1 STRTVALLVAADCSYVAAFgGDAAQANIINMVNTASNVYERDF--N-ISLGLVNLT-ISDSTCPYTPPAcstgDSSDRLS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    366 NFcQWQHSKNspGGIHHDTAVLLTrqdicraHDKCDTLGLAELGTICDPYRSCSISEDSG--------LSTAFTIAHELG 437
Cdd:pfam13688   77 EF-QDFSAWR--GTQNDDLAYLFL-------MTNCSGGGLAWLGQLCNSGSAGSVSTRVSgnnvvvstATEWQVFAHEIG 146

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 33624896    438 HVFNMPHDDNNKCKEEG--------VKSPQHVMAPTLNFYTNPW 473
Cdd:pfam13688  147 HNFGAVHDCDSSTSSQCcppsnstcPAGGRYIMNPSSSPNSTDF 190
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1559-1612 2.55e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.24  E-value: 2.55e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1559 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1332-1383 4.32e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 4.32e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1332 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1383
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 591-642 7.71e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.83  E-value: 7.71e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896     591 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1501-1554 5.99e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 5.99e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1501 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1554
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1056-1108 6.61e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.61e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1056 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1445-1498 6.80e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.80e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1498
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1001-1053 7.15e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.15e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1053
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 316-445 2.26e-10

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 60.08  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    316 YILTLMSIVASIY-KDPSIG-NLINIVIVNLivihneQDGPSISFNAQTTLKNFCQWQHskNSPGGIHHDTAVLLTRQDi 393
Cdd:pfam13582    2 RIVSLVNRANTIYeRDLGIRlQLAAIIITTS------ADTPYTSSDALEILDELQEVND--TRIGQYGYDLGHLFTGRD- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    394 crahdKCDTLGLAELGTICDPYRSCSISEDS---GLSTAFTIAHELGHVFNMPHD 445
Cdd:pfam13582   73 -----GGGGGGIAYVGGVCNSGSKFGVNSGSgpvGDTGADTFAHEIGHNFGLNHT 122
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 648-752 2.90e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 59.34  E-value: 2.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    648 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 717
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 33624896    718 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 752
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1186-1239 5.57e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 5.57e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1186 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1239
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1242-1295 6.98e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896   1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1295
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1681-1729 8.06e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 8.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33624896   1681 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1729
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 312-487 1.24e-08

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 56.87  E-value: 1.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    312 NLQHYILTLMSIVASIYKDPSIGnlINIVIVN---LIVIHNEQD-GPSISFNAQTTLKN---FCQWQHSKNspggihHDT 384
Cdd:pfam13574    2 NVTENLVNVVNRVNQIYEPDDIN--INGGLVNpgeIPATTSASDsGNNYCNSPTTIVRRlnfLSQWRGEQD------YCL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896    385 AVLLTRQDICRAhdkcdTLGLAELGTICDPYRSCsISEDSGLSTAFT-------------IAHELGHVFNMPHDDN---- 447
Cdd:pfam13574   74 AHLVTMGTFSGG-----ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDCDgsqy 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 33624896    448 --NKCKEEGVKSP-----QHVMAPT---LNFytnpwMWSKCSRKYITEFL 487
Cdd:pfam13574  148 asSGCERNAATSVcsangSFIMNPAsksNND-----LFSPCSISLICDVL 192
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1616-1675 2.30e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.30e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33624896   1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1675
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 298-501 4.74e-07

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 53.15  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  298 LVVADNRMVSYHGENLQ----HYILTLMSIVASIYKDPSIGNLI--NI-VIVNLIVIHNEQDgPSISFNAQTtlkNFC-- 368
Cdd:cd04270    6 LLVADHRFYKYMGRGEEettiNYLISHIDRVDDIYRNTDWDGGGfkGIgFQIKRIRIHTTPD-EVDPGNKFY---NKSfp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  369 -----QWQHSKNSPGgiHHDtavlltrqDICRAHDKCD------TLGLAELGT--------ICDPYRSCS----ISEDSG 425
Cdd:cd04270   82 nwgveKFLVKLLLEQ--FSD--------DVCLAHLFTYrdfdmgTLGLAYVGSprdnsaggICEKAYYYSngkkKYLNTG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  426 LSTAF-------------TIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAP--TLNFYTNPWMWSKCSRKYITEFLDT 489
Cdd:cd04270  152 LTTTVnygkrvptkesdlVTAHELGHNFGSPHDpDIAECAPGESQGGNYIMYAraTSGDKENNKKFSPCSKKSISKVLEV 231

                        250
                 ....*....|..
gi 33624896  490 GYGEClLNEPES 501
Cdd:cd04270  232 KSNSC-FVERSQ 242
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 592-642 4.92e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 4.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 33624896    592 GSWSPFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 642
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1239-1296 1.74e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 1.74e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 33624896    1239 CGQWKalDWSSCSVTCGQGRATRQVMCVNYSDHViDRSECDQDYiPETdQDCSMSPCP 1296
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1001-1054 2.04e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.73  E-value: 2.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVTIQRCSEFPCP 1054
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1199-1317 2.31e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33624896  1199 GKGTRMRY----VSCRDENG-----SVADESACATLPRPVAKEECS----VTPCGQWKalDWSSCSVTCGQGRATRQ--V 1263
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 33624896  1264 MCVNYSDHVIdrSECDQDyipetdqDCSMSPCPQRTPDsglaQHPFQNEDYRPR 1317
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPA----PVPPTPEDDNPR 305
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 885-931 2.36e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 2.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33624896    885 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 931
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1186-1239 4.10e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 4.10e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVaDESACATLPRpvAKEECSVTPC 1239
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1562-1613 5.09e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 5.09e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1562 EEWQECTKTCGEGSRYRKVVCVdDNKNEVHGARCDVSKRpvDRESCSLQPCE 1613
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
591-642 5.33e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.41  E-value: 5.33e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33624896    591 WGSWSPfgtCSRTCGGGIKTAIRECNRPEPknGGKYCVGRRMKFKSCNTEPC 642
Cdd:pfam00090    3 WSPWSP---CSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1059-1103 1.25e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 33624896    1059 GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC---DPETKPTSMQTC 1103
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCtgeDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1386-1440 1.40e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.42  E-value: 1.40e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    1386 WAYGNWGECTKLCGGGIRTRLVVCQrSNGERFPDLSCEILDkpPDREQCNTHACP 1440
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1332-1384 4.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 4.61e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 33624896    1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1384
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1445-1499 5.34e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 5.34e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDyCKHLAKPhgHRKCRGGRCP 1499
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP-CTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1504-1555 9.55e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 9.55e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1504 GAWSQCSVSCGRGVQQRHVGCqIGTHKIARETECNPYTRpeSERDCQGPRCP 1555
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1188-1209 1.02e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.55  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|..
gi 33624896   1188 FGSWTPCSATCGKGTRMRYVSC 1209
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 939-993 1.89e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.89e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33624896    939 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 996-1053 2.69e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 2.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 33624896    996 CNTGGWrySAWTECSKSCDGGTQRR-RAICVNTRNdvlDDSKCTHQEKVtiQRCSEFPC 1053
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTRtRTVIVEPQN---GGRPCPELLER--RPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1615-1676 2.85e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.85e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33624896    1615 VWITGEWSECSVTCGKGYKQRLVSCseiytgkeNYEYSYQTTINCPGtQPPSVHPCYLRDCP 1676
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC--------CSPPPQNGGGPCTG-EDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1188-1239 6.09e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 6.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 33624896   1188 FGSWTPCSATCGKG--TRMRYVSCRDENGSvadeSACatlPRPVAKEECSVTPC 1239
Cdd:pfam19028    6 WSEWSECSVTCGGGvqTRTRTVIVEPQNGG----RPC---PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1114-1166 6.58e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 6.58e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 33624896    1114 GPWGQCSVTCGQGYQLRAVKCIIGTymSVVDDNDCNAATRptDTQDCELPSCH 1166
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1618-1639 7.75e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.24  E-value: 7.75e-03
                           10        20
                   ....*....|....*....|..
gi 33624896   1618 TGEWSECSVTCGKGYKQRLVSC 1639
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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