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Conserved domains on  [gi|33469931|ref|NP_877950|]
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pikachurin isoform 2 [Homo sapiens]

Protein Classification

EGF_CA and LamG domain-containing protein( domain architecture ID 10059433)

EGF_CA and LamG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 626-751 1.74e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.92  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   626 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 704
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 33469931   705 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 157-307 1.08e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 126.38  E-value: 1.08e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 157 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 236
Cdd:cd00110   4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33469931 237 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 307
Cdd:cd00110  82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 384-531 1.31e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.60  E-value: 1.31e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 384 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 463
Cdd:cd00110   8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33469931 464 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 531
Cdd:cd00110  85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 558-586 2.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.18e-06
                        10        20
                ....*....|....*....|....*....
gi 33469931 558 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
Cdd:cd00054  10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 326-368 4.73e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.73e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 33469931 326 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 368
Cdd:cd00054   1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 626-751 1.74e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.92  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   626 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 704
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 33469931   705 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 157-307 1.08e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 126.38  E-value: 1.08e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 157 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 236
Cdd:cd00110   4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33469931 237 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 307
Cdd:cd00110  82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 598-747 3.85e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 124.84  E-value: 3.85e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 598 FIGRSYLTYDNPDILKRvsgsRSNVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS 677
Cdd:cd00110   4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 678 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCIS 747
Cdd:cd00110  77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
621-751 4.25e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 4.25e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    621 NVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMV-NGSFNDGRWHRVKAVRDGQSGKITV 699
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33469931    700 DDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Cdd:smart00282  78 DGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 384-531 1.31e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.60  E-value: 1.31e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 384 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 463
Cdd:cd00110   8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33469931 464 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 531
Cdd:cd00110  85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
402-533 1.19e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ 480
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 33469931    481 KIVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGVLKPFSGSIQKIILNDR 533
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
181-312 2.42e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.18  E-value: 2.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   181 FRAEAEDGLLLYCGENEHGrgDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT 260
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33469931   261 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRID 312
Cdd:pfam00054  79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
176-309 7.22e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.05  E-value: 7.22e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    176 QITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-TKIKLGGWHTVMLYRDGLNGLLQLN 254
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33469931    255 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 309
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 407-533 1.17e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.97  E-value: 1.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   407 FRPDSGDGVLLYSYDtGSKDFLSINLAGGHVEFRFDCGSGTGVLRS-EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEG 485
Cdd:pfam02210   1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 33469931   486 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGVLKPFSGSIQKIILNDR 533
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 558-586 2.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.18e-06
                        10        20
                ....*....|....*....|....*....
gi 33469931 558 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
Cdd:cd00054  10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 326-368 4.73e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.73e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 33469931 326 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 368
Cdd:cd00054   1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 554-584 2.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 2.58e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 33469931   554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLH 584
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
558-586 6.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.93e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 33469931    558 PCAHGGSCRPRKEGYDCDCPLGFE-GLHCQ 586
Cdd:smart00179  10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
326-368 5.15e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 5.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 33469931    326 DVGECSSGicdeASCIHGGTCTAiKADSYICLCPLGFK-GRHCE 368
Cdd:smart00179   1 DIDECASG----NPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 335-366 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 6.09e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 33469931   335 CDEASCIHGGTCTAIKaDSYICLCPLGFKGRH 366
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 626-751 1.74e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.92  E-value: 1.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   626 FKTTAKDGLLLWRGDSpmrpNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRVKAVRDGQSGKITVDDYGA 704
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESLLSSGKnLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 33469931   705 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Cdd:pfam02210  77 VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 157-307 1.08e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 126.38  E-value: 1.08e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 157 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 236
Cdd:cd00110   4 FSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQ--NGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQ 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33469931 237 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVN 307
Cdd:cd00110  82 WHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 598-747 3.85e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 124.84  E-value: 3.85e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 598 FIGRSYLTYDNPDILKRvsgsRSNVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS 677
Cdd:cd00110   4 FSGSSYVRLPTLPAPRT----RLSISFSFRTTSPNGLLLYAGS---QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 678 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCIS 747
Cdd:cd00110  77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIR 146
LamG smart00282
Laminin G domain;
621-751 4.25e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 4.25e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    621 NVFMRFKTTAKDGLLLWRGDspmRPNSDFISLGLRDGALVFSYNLGSGVASIMV-NGSFNDGRWHRVKAVRDGQSGKITV 699
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGS---KGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 33469931    700 DDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Cdd:smart00282  78 DGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 384-531 1.31e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.60  E-value: 1.31e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931 384 SYAATPWPlepQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 463
Cdd:cd00110   8 SYVRLPTL---PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33469931 464 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKnSGVLKPFSGSIQKIILN 531
Cdd:cd00110  85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
402-533 1.19e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 1.19e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ 480
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 33469931    481 KIVEGMAEGGFTQIKCNTDIFIGGVPNyDDVKKNSGVLKPFSGSIQKIILNDR 533
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
181-312 2.42e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 113.18  E-value: 2.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   181 FRAEAEDGLLLYCGENEHGrgDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT 260
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTER--DFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 33469931   261 GQSQ-GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRID 312
Cdd:pfam00054  79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
176-309 7.22e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.05  E-value: 7.22e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931    176 QITLEFRAEAEDGLLLYCGENehGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-TKIKLGGWHTVMLYRDGLNGLLQLN 254
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSK--GGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSVD 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 33469931    255 NGTPVTGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 309
Cdd:smart00282  79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 407-533 1.17e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.97  E-value: 1.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   407 FRPDSGDGVLLYSYDtGSKDFLSINLAGGHVEFRFDCGSGTGVLRS-EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEG 485
Cdd:pfam02210   1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 33469931   486 MAEGGFTQIKCNTDIFIGGVPnYDDVKKNSGVLKPFSGSIQKIILNDR 533
Cdd:pfam02210  80 LPPGESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
626-746 5.82e-27

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 106.63  E-value: 5.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   626 FKTTAKDGLLLWRGdspMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGAR 705
Cdd:pfam00054   1 FRTTEPSGLLLYNG---TQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 33469931   706 TGKSP-GMMRQLNINGALYVGGMKEIALHTNRQ-YMRGLVGCI 746
Cdd:pfam00054  78 TGESPlGATTDLDVDGPLYVGGLPSLGVKKRRLaISPSFDGCI 120
Laminin_G_1 pfam00054
Laminin G domain;
407-536 2.53e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 101.62  E-value: 2.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   407 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGM 486
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 33469931   487 AEGGFTQ-IKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIH 536
Cdd:pfam00054  81 SPLGATTdLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 181-309 2.90e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.56  E-value: 2.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469931   181 FRAEAEDGLLLYCGEnehGRGDFMSLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPV 259
Cdd:pfam02210   1 FRTRQPNGLLLYAGG---GGSDFLALELVNGRLVLRYDLGSGpESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 33469931   260 TGQSQGQYSKITFRTPLYLGGAPSAYwLVRATGTNRGFQGCVQSLAVNGR 309
Cdd:pfam02210  78 SSLPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 558-586 2.18e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.18e-06
                        10        20
                ....*....|....*....|....*....
gi 33469931 558 PCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
Cdd:cd00054  10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 326-368 4.73e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.73e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 33469931 326 DVGECSSGicdeASCIHGGTCTAIKaDSYICLCPLGFKGRHCE 368
Cdd:cd00054   1 DIDECASG----NPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 554-584 2.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 2.58e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 33469931   554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLH 584
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
558-586 6.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.93e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 33469931    558 PCAHGGSCRPRKEGYDCDCPLGFE-GLHCQ 586
Cdd:smart00179  10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 558-586 1.11e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.77  E-value: 1.11e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 33469931 558 PCAHGGSCRPRKEGYDCDCPLGFEG-LHCQ 586
Cdd:cd00053   7 PCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
326-368 5.15e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 5.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 33469931    326 DVGECSSGicdeASCIHGGTCTAiKADSYICLCPLGFK-GRHCE 368
Cdd:smart00179   1 DIDECASG----NPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 335-366 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 6.09e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 33469931   335 CDEASCIHGGTCTAIKaDSYICLCPLGFKGRH 366
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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