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Conserved domains on  [gi|32699064|ref|NP_872433|]
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WD repeat-containing protein 53 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-272 1.59e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKdS 86
Cdd:COG2319  76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-L 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  87 LDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSL 166
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 167 QKARPLWITNLQEDEteemegpqspgqllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGfkGHTSGVSQ 246
Cdd:COG2319 234 ATGKLLRTLTGHSGS------------------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNS 293

                       250       260
                ....*....|....*....|....*.
gi 32699064 247 VCFLPESYLLLTGGNDGKITLWDANS 272
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLAT 319
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-272 1.59e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKdS 86
Cdd:COG2319  76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-L 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  87 LDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSL 166
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 167 QKARPLWITNLQEDEteemegpqspgqllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGfkGHTSGVSQ 246
Cdd:COG2319 234 ATGKLLRTLTGHSGS------------------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNS 293

                       250       260
                ....*....|....*....|....*.
gi 32699064 247 VCFLPESYLLLTGGNDGKITLWDANS 272
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-269 7.31e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 7.31e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTrFQG-ADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKD 85
Cdd:cd00200  49 GHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVRT-LTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  86 SLDhFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:cd00200 128 LTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 166 LQKARPLwitnlqedetEEMEGPQSPgqllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELgfKGHTSGVS 245
Cdd:cd00200 206 LSTGKCL----------GTLRGHENG--------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL--SGHTNSVT 265

                       250       260
                ....*....|....*....|....
gi 32699064 246 QVCFLPESYLLLTGGNDGKITLWD 269
Cdd:cd00200 266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-269 2.00e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32699064    237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-269 2.12e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.12e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 32699064   237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
8-272 1.59e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKdS 86
Cdd:COG2319  76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-L 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  87 LDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSL 166
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 167 QKARPLWITNLQEDEteemegpqspgqllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGfkGHTSGVSQ 246
Cdd:COG2319 234 ATGKLLRTLTGHSGS------------------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNS 293

                       250       260
                ....*....|....*....|....*.
gi 32699064 247 VCFLPESYLLLTGGNDGKITLWDANS 272
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-269 7.31e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 7.31e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWGEDGTPLGHTrFQG-ADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKD 85
Cdd:cd00200  49 GHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVRT-LTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  86 SLDhFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:cd00200 128 LTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 166 LQKARPLwitnlqedetEEMEGPQSPgqllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELgfKGHTSGVS 245
Cdd:cd00200 206 LSTGKCL----------GTLRGHENG--------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL--SGHTNSVT 265

                       250       260
                ....*....|....*....|....
gi 32699064 246 QVCFLPESYLLLTGGNDGKITLWD 269
Cdd:cd00200 266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-272 1.16e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 1.16e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWG-EDGTPL----GHTrfqgaDDVTSVLFSPSCPTKLYASHGETISVLDVR 81
Cdd:COG2319 118 GHTGAVRSVAFSPDGkTLASGSADGTVRLWDlATGKLLrtltGHS-----GAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  82 SLKdSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQV 161
Cdd:COG2319 193 TGK-LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 162 MLWSLQKARPLWITNLQEDETEEM----EGPQ---------------SPGQLLNPALAHSISVASC-----GNIFSCGAE 217
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVafspDGKLlasgsddgtvrlwdlATGKLLRTLTGHTGAVRSVafspdGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32699064 218 DGKVRIFRVMGVKCEQELgfKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANS 272
Cdd:COG2319 351 DGTVRLWDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-277 1.04e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 1.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064   8 GHSSPVLCLNASKEG-LLASGAEGGDLTAWG-EDGTPLghTRFQG-ADDVTSVLFSPScpTKLYASHGE--TISVLDVRS 82
Cdd:cd00200   7 GHTGGVTCVAFSPDGkLLATGSGDGTIKVWDlETGELL--RTLKGhTGPVRDVAASAD--GTYLASGSSdkTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  83 LKdSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQrPQSLVSCGLDMQVM 162
Cdd:cd00200  83 GE-CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 163 LWSLQKARPLWitnlqedeteEMEGPQSPGqllnpalaHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELgfKGHTS 242
Cdd:cd00200 161 LWDLRTGKCVA----------TLTGHTGEV--------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL--RGHEN 220

                       250       260       270
                ....*....|....*....|....*....|....*
gi 32699064 243 GVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKK 277
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 44-278 5.72e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 5.72e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  44 GHTrfqgaDDVTSVLFSPSCPTKLYASHGETISVLDVRSlKDSLDHFHVNEEEIN-CLSLNQTENLLASADDsGAIKILD 122
Cdd:cd00200   7 GHT-----GGVTCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRdVAASADGTYLASGSSD-KTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 123 LENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSLQKARPlwITNLQedeteemeGPQSPgqllnpalAHS 202
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKC--LTTLR--------GHTDW--------VNS 140

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32699064 203 ISVASCGNIFSCGAEDGKVRIFRVMGVKCEQElgFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQ 278
Cdd:cd00200 141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
23-272 5.74e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 5.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  23 LLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDsLDHFHVNEEEINCLSL 102
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL-LATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 103 NQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSLQKarplwitnlqedet 182
Cdd:COG2319  87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLAT-------------- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 183 eemegpqspGQLLNPALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCEQELgfKGHTSGVSQVCFLPESYLLL 257
Cdd:COG2319 152 ---------GKLLRTLTGHSGAVTSVafspdGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLA 220

                       250
                ....*....|....*
gi 32699064 258 TGGNDGKITLWDANS 272
Cdd:COG2319 221 SGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 129-277 2.02e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 2.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064 129 IRSLKRHSNICSSVAFRPQrPQSLVSCGLDMQVMLWSLQKARPLwitnlqedetEEMEGPQSPGQLLNpALAHSISVASC 208
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELL----------RTLKGHTGPVRDVA-ASADGTYLASG 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32699064 209 GNifscgaeDGKVRIFRVMGVKCEQElgFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKK 277
Cdd:cd00200  70 SS-------DKTIRLWDLETGECVRT--LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-269 2.00e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32699064    237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-269 2.12e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.12e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 32699064   237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWD 269
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-278 1.34e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 1.34e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 32699064 237 FKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQ 278
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT 46
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 93-136 7.16e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 7.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 32699064    93 NEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHS 136
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-165 7.89e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 7.89e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 32699064    125 NKKVIRSLKRHSNICSSVAFRPQRPQsLVSCGLDMQVMLWS 165
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 54-172 2.16e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.52  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32699064  54 VTSVLF-SPSCPTKLYAS--HGEtISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIR 130
Cdd:cd22857 181 VTDLTFlSKDDHRKIVTGtgYHQ-VRLYDTRAQRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLG 259

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 32699064 131 SLKrhsNICSSVAFRPQRPQSL---VSCGLDMQVMLWSLQKARPL 172
Cdd:cd22857 260 CFK---GKCGGSIRSIARHPELpliASCGLDRYLRIWDTETRQLL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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