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Conserved domains on  [gi|194097375|ref|NP_872414|]
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photoreceptor ankyrin repeat protein isoform 2 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
98-240 4.99e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 4.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375  98 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 173
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097375 174 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRC----------ADLTAVDPvRGKTALEWAVLTDSFDTV 240
Cdd:COG0666  162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLeivkllleagADVNAKDN-DGKTALDLAAENGNLEIV 235
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
98-240 4.99e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 4.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375  98 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 173
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097375 174 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRC----------ADLTAVDPvRGKTALEWAVLTDSFDTV 240
Cdd:COG0666  162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLeivkllleagADVNAKDN-DGKTALDLAAENGNLEIV 235
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-197 4.70e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 4.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375   99 LYWACVHNDPTQLQAILDGGVspeEATQVDSNGRTGLMVACYHGFQSVVALLshCPFLDVNQQDKGgDTALMLAAQAGHV 178
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA---DANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDNG-RTALHYAARSGHL 74

                          90
                  ....*....|....*....
gi 194097375  179 PLVSLLLNYyvGLDLERRD 197
Cdd:pfam12796  75 EIVKLLLEK--GADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 111-240 4.13e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375 111 LQAILDGGVSPEEAtqvDSNGRTGLMVACYHGFQS-VVALLSH-CpflDVNQQDKGGDTALMLAAQAGHVPLVSLLLNY- 187
Cdd:PLN03192 541 LEELLKAKLDPDIG---DSKGRTPLHIAASKGYEDcVLVLLKHaC---NVHIRDANGNTALWNAISAKHHKIFRILYHFa 614

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097375 188 -----YVGLDL-----ERRDQRGLTALMKAAMrnrcaDLTAVDPvRGKTALEWAVLTDSFDTV 240
Cdd:PLN03192 615 sisdpHAAGDLlctaaKRNDLTAMKELLKQGL-----NVDSEDH-QGATALQVAMAEDHVDMV 671
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
98-240 4.99e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 4.99e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375  98 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 173
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194097375 174 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRC----------ADLTAVDPvRGKTALEWAVLTDSFDTV 240
Cdd:COG0666  162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLeivkllleagADVNAKDN-DGKTALDLAAENGNLEIV 235
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-197 4.70e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 4.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375   99 LYWACVHNDPTQLQAILDGGVspeEATQVDSNGRTGLMVACYHGFQSVVALLshCPFLDVNQQDKGgDTALMLAAQAGHV 178
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA---DANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDNG-RTALHYAARSGHL 74

                          90
                  ....*....|....*....
gi 194097375  179 PLVSLLLNYyvGLDLERRD 197
Cdd:pfam12796  75 EIVKLLLEK--GADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
135-212 3.69e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 3.69e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194097375  135 LMVACYHGFQSVVALLSHCPFlDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvgLDLERRDQrGLTALMKAAMRNR 212
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDN-GRTALHYAARSGH 73
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
98-211 5.77e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 5.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375  98 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVV-ALLSHCPflDVNQQDKGGDTALMLAAQAG 176
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVN---ARDNDGETPLHLAAENGHLEIVkLLLEAGA--DVNAKDNDGKTALDLAAENG 230

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 194097375 177 HVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRN 211
Cdd:COG0666  231 NLEIVKLLLEA--GADLNAKDKDGLTALLLAAAAG 263
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-249 1.88e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375 128 DSNGRTGLMVACYHGFQSVVALLSHcPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKA 207
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLA-AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA--GADVNARDKDGETPLHLA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194097375 208 AMRNRC----------ADLTAVDPvRGKTALEWAVLTDSFDTVwriRQLLRR 249
Cdd:COG0666  128 AYNGNLeivkllleagADVNAQDN-DGNTPLHLAAANGNLEIV---KLLLEA 175
Ank_5 pfam13857
Ankyrin repeats (many copies);
149-204 7.68e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 7.68e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194097375  149 LLSHCPfLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTAL 204
Cdd:pfam13857   1 LLEHGP-IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY--GVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
131-185 1.18e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 1.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 194097375  131 GRTGLMVACYHGFQSVVALLsHCPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLL 185
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLL-LEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
165-212 1.94e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 194097375  165 GDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNR 212
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK--GADINAVDGNGETALHFAASNGN 46
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 111-240 4.13e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375 111 LQAILDGGVSPEEAtqvDSNGRTGLMVACYHGFQS-VVALLSH-CpflDVNQQDKGGDTALMLAAQAGHVPLVSLLLNY- 187
Cdd:PLN03192 541 LEELLKAKLDPDIG---DSKGRTPLHIAASKGYEDcVLVLLKHaC---NVHIRDANGNTALWNAISAKHHKIFRILYHFa 614

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097375 188 -----YVGLDL-----ERRDQRGLTALMKAAMrnrcaDLTAVDPvRGKTALEWAVLTDSFDTV 240
Cdd:PLN03192 615 sisdpHAAGDLlctaaKRNDLTAMKELLKQGL-----NVDSEDH-QGATALQVAMAEDHVDMV 671
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
146-249 6.45e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097375 146 VVALLSHCPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRC----------AD 215
Cdd:COG0666   35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAA--GADINAKDDGGNTLLHAAARNGDLeivkllleagAD 112

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194097375 216 LTAVDPvRGKTALEWAVLTDSFDTVwriRQLLRR 249
Cdd:COG0666  113 VNARDK-DGETPLHLAAYNGNLEIV---KLLLEA 142
Ank_4 pfam13637
Ankyrin repeats (many copies);
95-150 2.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 2.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194097375   95 RLGALYWACVHNDPTQLQAILDGGVSPEEatqVDSNGRTGLMVACYHGFQSVVALL 150
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINA---VDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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