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Conserved domains on  [gi|194440673|ref|NP_872335|]
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THAP domain-containing protein 5 isoform 2 [Homo sapiens]

Protein Classification

THAP domain-containing protein( domain architecture ID 10527248)

THAP domain-containing protein may act as a DNA-binding transcription regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 1-42 4.27e-10

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 461662  Cd Length: 76  Bit Score: 55.62  E-value: 4.27e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194440673    1 MKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIF 42
Cdd:pfam05485  35 CKRKDLPPPSNSYVCSLHFEENDFEKSGGKRKLKPGAIPTLF 76
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 1-42 4.27e-10

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 55.62  E-value: 4.27e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194440673    1 MKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIF 42
Cdd:pfam05485  35 CKRKDLPPPSNSYVCSLHFEENDFEKSGGKRKLKPGAIPTLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-43 9.39e-09

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 51.67  E-value: 9.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194440673     4 DSWVPSKYQFLCSDHFTPDSLDIRWgiRYLKQTAVPTIFS 43
Cdd:smart00980  43 PNRKPKKRSRICSRHFEPDDFDNSG--RRLKPGAVPTLFL 80
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 1-42 4.27e-10

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 55.62  E-value: 4.27e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194440673    1 MKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIF 42
Cdd:pfam05485  35 CKRKDLPPPSNSYVCSLHFEENDFEKSGGKRKLKPGAIPTLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-43 9.39e-09

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 51.67  E-value: 9.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194440673     4 DSWVPSKYQFLCSDHFTPDSLDIRWgiRYLKQTAVPTIFS 43
Cdd:smart00980  43 PNRKPKKRSRICSRHFEPDDFDNSG--RRLKPGAVPTLFL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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