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Conserved domains on  [gi|144953913|ref|NP_872321|]
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zinc finger protein 714 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 4.06e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 171 NSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKC--EECGKAFKHSSTLTTHKMIHTGEKPYRCEecgKAFYHSSHLTTH- 247
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 248 KVIHTGEKPFKCE-ECGKAFNHPSALTTHKFIHVKEKPYKCeeCDKAFNRFSYLTKHKIIHSGEKSYKCEQCGKGFNWSS 326
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 327 TLtkHKRIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKLTIHKIIHTGEKPYKCEECGKAF 406
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 407 NQSSNLTKHKIIHTGE-------KLYKCEECGKAFNRSSNLTTHKR--IHTGE--KPYKCEE--CGKAFNRSSNLTKHNI 473
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|...
gi 144953913 474 IHTGEKSYKC--EECGKAFNQSSTLTKHRKIQQ 504
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
KRAB super family cl42959
krueppel associated box;
2-36 7.94e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.94e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 144953913     2 NVMLENYKNLVFLaGIAVSKQDPITSLEQEKEPWN 36
Cdd:smart00349  28 DVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
131-154 8.27e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....
gi 144953913  131 NSNRHKTRHTGEKPFKCKKCDESF 154
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 4.06e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 171 NSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKC--EECGKAFKHSSTLTTHKMIHTGEKPYRCEecgKAFYHSSHLTTH- 247
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 248 KVIHTGEKPFKCE-ECGKAFNHPSALTTHKFIHVKEKPYKCeeCDKAFNRFSYLTKHKIIHSGEKSYKCEQCGKGFNWSS 326
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 327 TLtkHKRIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKLTIHKIIHTGEKPYKCEECGKAF 406
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 407 NQSSNLTKHKIIHTGE-------KLYKCEECGKAFNRSSNLTTHKR--IHTGE--KPYKCEE--CGKAFNRSSNLTKHNI 473
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|...
gi 144953913 474 IHTGEKSYKC--EECGKAFNQSSTLTKHRKIQQ 504
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
KRAB smart00349
krueppel associated box;
2-36 7.94e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.94e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 144953913     2 NVMLENYKNLVFLaGIAVSKQDPITSLEQEKEPWN 36
Cdd:smart00349  28 DVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 144953913  439 NLTTHKRIHTGEKPYKCEECGKAFNR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
131-154 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....
gi 144953913  131 NSNRHKTRHTGEKPFKCKKCDESF 154
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-504 4.06e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 171 NSYQCEECDKVFKRFSTLTRHKRVHTGEKPFKC--EECGKAFKHSSTLTTHKMIHTGEKPYRCEecgKAFYHSSHLTTH- 247
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 248 KVIHTGEKPFKCE-ECGKAFNHPSALTTHKFIHVKEKPYKCeeCDKAFNRFSYLTKHKIIHSGEKSYKCEQCGKGFNWSS 326
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 327 TLtkHKRIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKLTIHKIIHTGEKPYKCEECGKAF 406
Cdd:COG5048  187 LI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 407 NQSSNLTKHKIIHTGE-------KLYKCEECGKAFNRSSNLTTHKR--IHTGE--KPYKCEE--CGKAFNRSSNLTKHNI 473
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|...
gi 144953913 474 IHTGEKSYKC--EECGKAFNQSSTLTKHRKIQQ 504
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
KRAB smart00349
krueppel associated box;
2-36 7.94e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.94e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 144953913     2 NVMLENYKNLVFLaGIAVSKQDPITSLEQEKEPWN 36
Cdd:smart00349  28 DVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-476 9.76e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 9.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 143 KPFKCKKCDESFCMLLHLHQHKRIHIRENSYQC--EECDKVFKRFSTLTRHKRVHTGEKPFKCE---------------- 204
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 205 -----------ECGKAFKHSSTLTTHKMIHTGEKPYRCE------------------------ECGKAFYHSSHLTTHKV 249
Cdd:COG5048  112 ssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPlpgnnsssvntpqsnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 250 IHTGEKPFKCEECGKAFNHPSALTTHKFIHVKEKPYKCEECDKAF------NRFSYLTKHKIIHSGEKSYKCEQCGKGFN 323
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 324 WSSTLTKHKRIHTG-EKPYKCEECGKAFNVSSHLTTHK--MIHTGE--KPYKCEE--CGKAFNHSSKLTIHKIIHTGEKP 396
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 397 YKC--EECGKAFNQSSN------LTKHKIIHTGEKLYKCE-ECGKAFNRSSNLTTHKRIHTGEKP--YKCEECGKAFNRS 465
Cdd:COG5048  352 AKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 144953913 466 SNLTKHNIIHT 476
Cdd:COG5048  432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
311-473 8.62e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 8.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 311 KSYKCEQCGKGFNWSSTLTKHKR--IHTGE--KPYKCEE--CGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKL 384
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 385 TI-------HKIIHTGEKPYKCE--ECGKAFNQSSNLTKHKIIHT--GEKLYKCEECGKAFNRSSNLTTHKRIHTGEKPY 453
Cdd:COG5048  368 NNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 144953913 454 KCEECGKaFNRSSNLTKHNI 473
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-359 1.28e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 199 KPFKCEECGKAFKHSSTLTTHK--MIHTGE--KPYRCEE--CGKAFYHSSHLTTHKVIHTGEKPFKCEEC------GKAF 266
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 267 NHPSALTTHKFIHVKEKPYKC---EECDKAFNRFSYLTKHKIIH--SGEKSYKCEQCGKGFNWSSTLTKHKRIHTGEKPY 341
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 144953913 342 KCEECGKaFNVSSHLTTH 359
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 198-308 9.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 198 EKPFKCEECGKAFKHSSTL---TTHKMIHT-GEKPYRCE--ECGKAFYHSSHLTTHKvIHTGEKPfkceecgKAFNHPSA 271
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQ-------KLHENPSP 386

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 144953913 272 LTTHKFIhVKEKPYKCEECDKAFNRFSYLtKHKIIHS 308
Cdd:COG5189  387 EKMNIFS-AKDKPYRCEVCDKRYKNLNGL-KYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 144953913  439 NLTTHKRIHTGEKPYKCEECGKAFNR 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-212 1.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.63e-04
                          10        20
                  ....*....|....*....|....*
gi 144953913  188 LTRHKRVHTGEKPFKCEECGKAFKH 212
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-320 2.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 171 NSYQCEECDKVFKRFSTLTRHKR--VHTGE--KPFKCEE--CGKAFKHSSTLTTHKMIHTGEKPYRC--EECGKAFYHSS 242
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 243 H-----LTTHKVIHTGEKPFKCE--ECGKAFNHPSALTTHKFIHVKEKP--YKCEECDKAFNRFSYLTKHKIIHSGEKSY 313
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*..
gi 144953913 314 KCEQCGK 320
Cdd:COG5048  448 LCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 352-501 2.75e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 352 VSSHLTTHKMIHTGEKPYKCEECGKAFNHSSKLTI----HKIIHTGEKPYKCE--ECGKAFNQSSNLTKHKiihtgekly 425
Cdd:COG5189  301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 144953913 426 kceecgkafnrssnLTTHKRIHTGEKPYKceecgkafnrssnlTKHNIIHTGEKSYKCEECGKAFNQSSTLTKHRK 501
Cdd:COG5189  372 --------------LHGHQNQKLHENPSP--------------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-304 3.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 143 KPFKCKKCDESFCMLLHLHQHKR--IHIRENSYQCEE----CDKVFKRFSTLTRHKRVHTGEKPFKC--EECGKAFKHSS 214
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 215 TLTTHKMIH-----TGEKPYRCE--ECGKAFYHSSHLTTHKVIHTGEKP--FKCEECGKAFNHPSALTTHKFIHVKEKPY 285
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 144953913 286 KCEECDKAFNRFSYLTKHK 304
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-351 5.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.18e-04
                          10        20
                  ....*....|....*....|....
gi 144953913  328 LTKHKRIHTGEKPYKCEECGKAFN 351
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-245 8.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 144953913 197 GEKPFKCE--ECGKAFKHSSTLTTHKM-------------------IHTGEKPYRCEECGKAF-------YHSSHLT 245
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYknlnglkYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-380 8.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 144953913  355 HLTTHKMIHTGEKPYKCEECGKAFNH 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-443 1.00e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 281 KEKPYKCEECDKAFNRFSYLTKHKIIHSGEKSYKC--EQCGKGFNWSSTLTKHKRIHTGEKPYKCE-ECGKAFNVSSHLT 357
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 358 THKMIHTGEKPYKCEECGKAFNHSSKLTIHKIIHTGEKPYKCEECGKAFNQSSNLTKHKIIHTGEKLYKCEECGKAFNRS 437
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189


                 ....*.
gi 144953913 438 SNLTTH 443
Cdd:COG5048  190 SNVSTS 195
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 144953913  243 HLTTHKVIHTGEKPFKCEECGKAFNH 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 337-416 3.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953913 337 GEKPYKCE--ECGKAFNVSSHLTTHkMIHTgekpykceECGKAFNHSSKLTIHKIIHTGEKPYKCEECGKAFNQSSNLTK 414
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 144953913 415 HK 416
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-408 3.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*
gi 144953913  384 LTIHKIIHTGEKPYKCEECGKAFNQ 408
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 5.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 144953913  411 NLTKHKIIHTGEKLYKCEECGKAFNR 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 5.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 144953913  467 NLTKHNIIHTGEKSYKCEECGKAFNQ 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 425-447 6.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|...
gi 144953913  425 YKCEECGKAFNRSSNLTTHKRIH 447
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-240 6.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 144953913  216 LTTHKMIHTGEKPYRCEECGKAFYH 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
131-154 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....
gi 144953913  131 NSNRHKTRHTGEKPFKCKKCDESF 154
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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