NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|32967597|ref|NP_870986|]
View 

pyruvate kinase PKLR isoform 2 [Homo sapiens]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 815.40  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 133
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 134 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 212
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 452
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 453 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 32967597 533 YTNIMRVLSI 542
Cdd:cd00288 471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 815.40  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 133
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 134 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 212
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 452
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 453 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 32967597 533 YTNIMRVLSI 542
Cdd:cd00288 471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 681.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597    55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   135 ILQGGPeseVELVKGSQVLVTVDPAFRTrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG-IKIISKIENHEGVKRFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   374 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   454 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 32967597   533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 642.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 135 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:COG0469  77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDE 294
Cdd:COG0469 151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469 231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 375 GETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLS 454
Cdd:COG0469 311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 455 RYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469 389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                ....*....
gi 32967597 534 TNIMRVLSI 542
Cdd:COG0469 463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 622.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597    54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   134 GILQGGPeSEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 32967597   373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 541.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LG-----RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  135 ILQGGPeseVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL---GpeGHGIKIISKIENHEGVKR 291
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 371
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  372 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEAAFK-CCAAAIIVLTTTGRSA 450
Cdd:PRK05826 311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32967597  451 QLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREP-PEAIWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 815.40  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 133
Cdd:cd00288   1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 134 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 212
Cdd:cd00288  75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:cd00288 152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288 232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 452
Cdd:cd00288 312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 453 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288 392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                       490
                ....*....|
gi 32967597 533 YTNIMRVLSI 542
Cdd:cd00288 471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 681.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597    55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   135 ILQGGPeseVELVKGSQVLVTVDPAFRTrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG-IKIISKIENHEGVKRFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   374 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   454 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 32967597   533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 642.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 135 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:COG0469  77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDE 294
Cdd:COG0469 151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469 231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 375 GETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLS 454
Cdd:COG0469 311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 455 RYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469 389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                ....*....
gi 32967597 534 TNIMRVLSI 542
Cdd:COG0469 463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 622.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597    54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   134 GILQGGPeSEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 32967597   373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 541.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LG-----RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  135 ILQGGPeseVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL---GpeGHGIKIISKIENHEGVKR 291
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 371
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  372 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEAAFK-CCAAAIIVLTTTGRSA 450
Cdd:PRK05826 311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32967597  451 QLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREP-PEAIWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 57-524 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 533.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   57 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIRTGIL 136
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN------TGILCAVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  137 Q-GGPeseVELVKGSQVLVTVDpaFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVT-QVENGG 213
Cdd:PLN02461  97 KdGKP---VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEaGTVRcRCENSA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  214 VLGSRKGVNLPGAQVDLPGLSEQDVRD-LRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 292
Cdd:PLN02461 172 MLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNF 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 372
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  373 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 452
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  453 LSRYRPRAAVIAV------TRSAQ-------AARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGD 519
Cdd:PLN02461 412 VAKYRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGD 491


                 ....*
gi 32967597  520 LVIVV 524
Cdd:PLN02461 492 SVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
55-539 1.99e-178

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 510.75  E-value: 1.99e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIRTG 134
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSK------TGKKAAILLDTKGPEIRTM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  135 ILQGGpeSEVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 214
Cdd:PRK09206  76 KLEGG--NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  215 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPE-GHGIKIISKIENHEGVKRFD 293
Cdd:PRK09206 152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 373
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  374 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRqlFEELRRAAPLsrDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 453
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSR--LESNNDNRKL--RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  454 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPpeaiwaDDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 533
Cdd:PRK09206 388 RKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI------ASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGT 461


                 ....*.
gi 32967597  534 TNIMRV 539
Cdd:PRK09206 462 TNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 55-539 2.92e-175

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 507.16  E-value: 2.92e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   55 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLG------KTVGILQDLQGPKIRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  135 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG--LVTQVENG 212
Cdd:PRK06354  82 RFEDGP---IELKTGDEFILTSRE---VLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  213 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPE-GHGIKIISKIENHEGVKR 291
Cdd:PRK06354 156 GVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 371
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  372 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplsrDPTEVTAIG-AV-EAAFKCCAAAIIVLTTTGRS 449
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF-----TTTITNAISqAVsHIALQLDAAAIVTLTKSGAT 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  450 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAiwaddvDRRVQFGIESGKLRGFLRVGDLVIVVTGWRP 529
Cdd:PRK06354 391 ARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPST------DETFDAAINVAQESGLLKQGDLVVITAGTLV 464

                        490
                 ....*....|.
gi 32967597  530 G-SGYTNIMRV 539
Cdd:PRK06354 465 GeSGSTDLMKV 475
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 81-543 1.04e-172

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 495.73  E-value: 1.04e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   81 MNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRTGILQGGpesEVELVKGSQVLVTVDPAF 160
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  161 RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVR 239
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  240 DLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVF 319
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  320 LAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEA 399
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  400 AVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCR 479
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32967597  480 GVFPLLYrePPEAIWADD-VDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 543
Cdd:PTZ00300 392 GVESVFF--DAERLGHDEgKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 32-542 2.20e-168

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 486.96  E-value: 2.20e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   32 AAMADTFLEHLCL-LDIDSEPVA-----ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVRE 105
Cdd:PTZ00066   9 SVMGCSLGKATNIsLDKILEPISdndlrQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  106 AVESfagsplsyRP---VAIALDTKGPEIRTGILQGGpeSEVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPV 182
Cdd:PTZ00066  89 AAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  183 GGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRD-LRFGVEHGVDIVFASFVRKAS 261
Cdd:PTZ00066 157 GNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSAD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  262 DVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQ 341
Cdd:PTZ00066 237 DVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQ 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  342 MLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPT 421
Cdd:PTZ00066 317 MLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQ 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  422 EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRR 501
Cdd:PTZ00066 397 EAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS------FQGTDVV 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 32967597  502 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVLSI 542
Cdd:PTZ00066 471 IRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
PRK06247 PRK06247
pyruvate kinase; Provisional
 54-543 6.51e-142

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 418.18  E-value: 6.51e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREaVESFAGsplsyRPVAIALDTKGPEIRT 133
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIRE-VEDETG-----RPIGILADLQGPKLRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  134 GILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGG 213
Cdd:PRK06247  78 GRFADGK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  214 VLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAlgpEGHGIKIISKIENHEGVKRFD 293
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 373
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  374 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEelrraapLSRDPTEVTAIGAVEAAFKCCA-----AAIIVLTTTGR 448
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLIH-------AQRPQPEATKRDAISYAARDIAerldlAALVAYTSSGD 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  449 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR 528
Cdd:PRK06247 382 TALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVP 455

                        490
                 ....*....|....*.
gi 32967597  529 PG-SGYTNIMRVLSIS 543
Cdd:PRK06247 456 PGtPGSTNMLRIAYIG 471
PLN02765 PLN02765
pyruvate kinase
 57-523 4.86e-117

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 355.90  E-value: 4.86e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   57 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIrtgIL 136
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPEL---QV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  137 QGGPESEVELVKGSQVLVTVD---PAfrtrgNANTVWVDYPNIVRVVPVGGRIYIDDGLIS--------LVVQKIGPEGL 205
Cdd:PLN02765 101 INKTEKPISLKAGNTVTLTPDqskEA-----SSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  206 VTQVENGGVL-GSRKGVNLPGAQVDLPGLSEQDVRDLR-FGVEHGVDIVFASFVRKASDVAAVRAALGPEG-HGIKIISK 282
Cdd:PLN02765 176 VCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAK 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  283 IENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVcATQMLESMITKPRPTRAETSDVAN 362
Cdd:PLN02765 256 IENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVAN 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  363 AVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEaAVYHRQLFeeLRRAAPLSRDP---TEVTAIGAVEAAFKCCAAA 439
Cdd:PLN02765 335 AVLDGADAILLGAETLRGLYPVETISTVGRICAEAE-KVFNQDLY--FKKTVKYVGEPmshLESIASSAVRAAIKVKASV 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  440 IIVLTTTGRSAQLLSRYRPRAAVIAVT-------------RSAQAARQVHLCRGVFPLLY--REPPEAIWADDvDRRVQF 504
Cdd:PLN02765 412 IIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLAdpRHSAESTSATN-ESVLKV 490

                        490
                 ....*....|....*....
gi 32967597  505 GIESGKLRGFLRVGDLVIV 523
Cdd:PLN02765 491 ALDHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 49-538 5.71e-103

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 321.49  E-value: 5.71e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   49 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPlsyrpVAIALDTKG 128
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV-----IAIMLDTKG 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  129 PEIRTGILqggPESeVELVKGSQVLVTVDpafRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ 208
Cdd:PLN02623 179 PEVRSGDL---PQP-IMLEEGQEFTFTIK---RGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCE 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  209 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG 288
Cdd:PLN02623 252 VVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADS 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  289 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGA 368
Cdd:PLN02623 332 IPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGA 411

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  369 DCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAfKCCAAAIIVLTTTGR 448
Cdd:PLN02623 412 DAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFK--NHMSEMFAFHATMMA-NTLGTSIIVFTRTGF 488

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  449 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPlLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTgwr 528
Cdd:PLN02623 489 MAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-----FSDDAEETFARALSLLLNKGMVKEGEEVALVQ--- 559

                        490
                 ....*....|
gi 32967597  529 pgSGYTNIMR 538
Cdd:PLN02623 560 --SGRQPIWR 567
PRK06739 PRK06739
pyruvate kinase; Validated
 60-398 5.63e-95

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 293.39  E-value: 5.63e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   60 IATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplsyrpVAIALDTKGPEIRTGILQGg 139
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  140 peSEVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRK 219
Cdd:PRK06739  75 --EQITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  220 GVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEILEV 298
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQyKETSPNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  299 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETA 378
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 32967597  379 KGNFPVEAVKMQHAIAREAE 398
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 54-536 8.52e-89

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 282.40  E-value: 8.52e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   54 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVRE--AVESFAgsplsyrpVAIALDTKGPEI 131
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA--------VAVMMDTEGSEI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  132 RTGILQGGPESEVElvKGSQVLVTVDpAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISL-VVQKIGPEgLVTQVE 210
Cdd:PLN02762  96 HMGDLGGASSAKAE--DGEEWTFTVR-KFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPD-VKCKCT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  211 NGGVLGSRKGVNL--PGAQVD-----LPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVR---AALGPEgHGIKII 280
Cdd:PLN02762 172 DPGLLLPRANLTFwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKsyiAARSRD-SDIGVI 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  281 SKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDV 360
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  361 ANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRR---AAPLSRDPTEVTAIGAVEAAFKCCA 437
Cdd:PLN02762 331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGV 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  438 AAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYReppeaiWADDVDRRVQFGIESGKLRGFLRV 517
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD------FSDDMESNLNKTFSLLKARGMIKS 484

                        490
                 ....*....|....*....
gi 32967597  518 GDLVIVVTGWRPGSGYTNI 536
Cdd:PLN02762 485 GDLVIAVSDLTPSSMLQSI 503
PRK08187 PRK08187
pyruvate kinase; Validated
 50-387 4.29e-56

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 195.62  E-value: 4.29e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   50 EPVAARSTSIIATI-GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKG 128
Cdd:PRK08187 128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERA-TG-----RRCKILMDLAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  129 PEIRTGILqGGPESEVELVKGSQVLVTVDPAF-RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVT 207
Cdd:PRK08187 202 PKIRTGAV-AGPLGKTRLYTGDRLALVAQGPPrRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  208 QV----ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGvDIVFASFVRKASDVAAVRAAL----GPEGHGIKI 279
Cdd:PRK08187 281 EVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALaarrPDDWRKLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  280 ISKIENHEGVKRFDEILEVSDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTR 354
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350
                 ....*....|....*....|....*....|...
gi 32967597  355 AETSDVANAvlDGADCIMLSgetaKGNFPVEAV 387
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 26-412 5.32e-43

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 162.04  E-value: 5.32e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   26 QQQQLPAAMADTFLEHLCLLDIDSE-----PVAARSTSIIATIgPASRS-----VERLkemIKAGMNIARLNFSHGSHEY 95
Cdd:PRK14725 105 GPAYPPEDTAVTFEEGDELLDEHAEallgpPPSGRPTRIMVTL-PTEAAddpdlVRRL---LAAGMDIARINCAHDDPEA 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   96 HAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTGILQGGPE-----------------SEVELVKGS-------- 150
Cdd:PRK14725 181 WRAMIANVRTAEEELG------RRCRIAMDLAGPKLRTGPIAPGPRviklrptrdalgrvltpARLWLTASEspppsppp 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  151 -QVLVTVDPAF-------------RTRG--------------------------NANTVWVDY----------------- 173
Cdd:PRK14725 255 gPVGLPVDPEWlarlepgdelrftDARGkkrkltvtevddegvlaegsqtaylaNGTLLRLGRhdstrvgglppveqklr 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  174 --------------------------------PNIVRVVPVGGRIYIDDGLISLVVQKIGPEGL---VTQVENGGV-LGS 217
Cdd:PRK14725 335 lkvgdrlvltrddapgdpaqgdapparisctlPEAFRAARVGERVWFDDGKIGAVVVKVEADEVelrITHARPGGSkLKA 414

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  218 RKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGvDIVFASFVRKASDVAAVRAALgpEGHGIK---IISKIENHEGVKRFDE 294
Cdd:PRK14725 415 GKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDAL--EKLGADdlgVVLKIETRRAFENLPR 491

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597  295 IL-----EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLdgAD 369
Cdd:PRK14725 492 ILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AE 569

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 32967597  370 CIMLSgetaKGNFPVEAVKMQHAIAREAEAavYHRQLFEELRR 412
Cdd:PRK14725 570 CVMLN----KGPHIVEAVRVLDDILRRMEE--HQRKKRSLLRR 606
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
328-539 1.54e-40

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 149.28  E-value: 1.54e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 328 RCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRqlf 407
Cdd:COG3848   1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYR--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597 408 eELRRAAPLSRDPTEVTAIG--AVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLL 485
Cdd:COG3848  78 -EQRVPRAKESSTTITDAIShaVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLL 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32967597 486 YREPPEAIwaDDVDRRVQFGIESgklrGFLRVGDLVIVVTGWRPG-SGYTNIMRV 539
Cdd:COG3848 157 VEESASTD--EMFAVAVALALEA----GLVKDGDLVVITAGVPVGvSGTTNLLKV 205
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 422-540 1.43e-35

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 128.75  E-value: 1.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967597   422 EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRR 501
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 32967597   502 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVL 540
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH