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Conserved domains on  [gi|32171233|ref|NP_859059|]
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RNA 5'-monophosphate methyltransferase [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 13391478)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 158-263 1.38e-28

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 105.70  E-value: 1.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233   158 FDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCH---YLLVEPQPWKCYRAAARRLRKLglhdFDHFHSLAIRgdmPNQI 234
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSETI----KANYKTIQLR---PEDF 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 32171233   235 VQILTQDHGMELICCFGNTS------WDRSLLLFR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEELGSTPegkskgFDRPIYLFR 108
UbiG super family cl34436
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-215 4.92e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


The actual alignment was detected with superfamily member COG2227:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 4.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233  71 LDVGCNSGDLSVALykhflslpdgetcsdASREFRLLCCDIDPVLVKRAEKECPFPDaLTFITLDFMNqrtrkvllssfL 150
Cdd:COG2227  29 LDVGCGTGRLALAL---------------ARRGADVTGVDISPEALEIARERAAELN-VDFVQGDLED-----------L 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171233 151 SQFGRSvFDIGFCMsitmwihlnhgdhglwEFLAHLsslchyllvePQPWKCYRAAARRLRKLGL 215
Cdd:COG2227  82 PLEDGS-FDLVICS----------------EVLEHL----------PDPAALLRELARLLKPGGL 119
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 158-263 1.38e-28

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 105.70  E-value: 1.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233   158 FDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCH---YLLVEPQPWKCYRAAARRLRKLglhdFDHFHSLAIRgdmPNQI 234
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSETI----KANYKTIQLR---PEDF 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 32171233   235 VQILTQDHGMELICCFGNTS------WDRSLLLFR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEELGSTPegkskgFDRPIYLFR 108
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-215 4.92e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 4.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233  71 LDVGCNSGDLSVALykhflslpdgetcsdASREFRLLCCDIDPVLVKRAEKECPFPDaLTFITLDFMNqrtrkvllssfL 150
Cdd:COG2227  29 LDVGCGTGRLALAL---------------ARRGADVTGVDISPEALEIARERAAELN-VDFVQGDLED-----------L 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171233 151 SQFGRSvFDIGFCMsitmwihlnhgdhglwEFLAHLsslchyllvePQPWKCYRAAARRLRKLGL 215
Cdd:COG2227  82 PLEDGS-FDLVICS----------------EVLEHL----------PDPAALLRELARLLKPGGL 119
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-186 4.43e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.00  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233    71 LDVGCNSGDLSVALYKHFlslpdgetcsdasrEFRLLCCDIDPVLVKRAEKECPFPDA-LTFITLDFMNqrtrkvllssf 149
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG--------------GARVTGVDLSPEMLERARERAAEAGLnVEFVQGDAED----------- 56

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 32171233   150 LSQFGRSvFDIGFCMSITMWIHLNHGDHGLWEFLAHL 186
Cdd:pfam13649  57 LPFPDGS-FDLVVSSGVLHHLPDPDLEAALREIARVL 92
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 158-263 1.38e-28

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 105.70  E-value: 1.38e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233   158 FDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCH---YLLVEPQPWKCYRAAARRLRKLglhdFDHFHSLAIRgdmPNQI 234
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRpggVLILEPQPWKSYKKAKRLSETI----KANYKTIQLR---PEDF 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 32171233   235 VQILTQDHGMELICCFGNTS------WDRSLLLFR 263
Cdd:pfam06859  74 EEYLLSEVGFESVEELGSTPegkskgFDRPIYLFR 108
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 71-215 4.92e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 4.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233  71 LDVGCNSGDLSVALykhflslpdgetcsdASREFRLLCCDIDPVLVKRAEKECPFPDaLTFITLDFMNqrtrkvllssfL 150
Cdd:COG2227  29 LDVGCGTGRLALAL---------------ARRGADVTGVDISPEALEIARERAAELN-VDFVQGDLED-----------L 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32171233 151 SQFGRSvFDIGFCMsitmwihlnhgdhglwEFLAHLsslchyllvePQPWKCYRAAARRLRKLGL 215
Cdd:COG2227  82 PLEDGS-FDLVICS----------------EVLEHL----------PDPAALLRELARLLKPGGL 119
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-186 4.43e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.00  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171233    71 LDVGCNSGDLSVALYKHFlslpdgetcsdasrEFRLLCCDIDPVLVKRAEKECPFPDA-LTFITLDFMNqrtrkvllssf 149
Cdd:pfam13649   2 LDLGCGTGRLTLALARRG--------------GARVTGVDLSPEMLERARERAAEAGLnVEFVQGDAED----------- 56

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 32171233   150 LSQFGRSvFDIGFCMSITMWIHLNHGDHGLWEFLAHL 186
Cdd:pfam13649  57 LPFPDGS-FDLVVSSGVLHHLPDPDLEAALREIARVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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