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Conserved domains on  [gi|110626175|ref|NP_851992|]
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DENN domain-containing protein 1B isoform 2 [Mus musculus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655153)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 17-196 3.95e-70

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 226.31  E-value: 3.95e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    17 RICLCILSYLPWFEVYYKLLNTLADYLAKELEEDLnETLKSLYNHPVPKANTPVNLS-----VHSCFITPDITGLPTIPe 91
Cdd:smart00799   2 PKCICILSRLPFFELFRKILNELYRLLPSSSNLPL-ELLISLLLYPVPPPGGSLVLVslgpgDLIELQRPLDSSLPLID- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    92 sRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 171
Cdd:smart00799  80 -FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIG 158

                          170       180
                   ....*....|....*....|....*
gi 110626175   172 IHSSLIERVKNKSLEDVVVLNVDTN 196
Cdd:smart00799 159 VHSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 228-293 1.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 83.11  E-value: 1.36e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110626175   228 GDGVARAFLRAQAALFGSYRDALRY---KPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGR 293
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 17-196 3.95e-70

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 226.31  E-value: 3.95e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    17 RICLCILSYLPWFEVYYKLLNTLADYLAKELEEDLnETLKSLYNHPVPKANTPVNLS-----VHSCFITPDITGLPTIPe 91
Cdd:smart00799   2 PKCICILSRLPFFELFRKILNELYRLLPSSSNLPL-ELLISLLLYPVPPPGGSLVLVslgpgDLIELQRPLDSSLPLID- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    92 sRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 171
Cdd:smart00799  80 -FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIG 158

                          170       180
                   ....*....|....*....|....*
gi 110626175   172 IHSSLIERVKNKSLEDVVVLNVDTN 196
Cdd:smart00799 159 VHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 19-196 2.21e-46

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 162.74  E-value: 2.21e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175   19 CLCILSYLPWFEVYYKLLNTLADYLAKELEEDLNETL--KSLYNHPVPKANTPVNLSVHS-----CFITPDITGLPTipE 91
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFiaNLLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL--E 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175   92 SRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 171
Cdd:pfam02141  83 GVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIG 162

                         170       180
                  ....*....|....*....|....*
gi 110626175  172 IHSSLIErVKNKSLEDVVVLNVDTN 196
Cdd:pfam02141 163 VHSRYFD-LLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 228-293 1.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 83.11  E-value: 1.36e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110626175   228 GDGVARAFLRAQAALFGSYRDALRY---KPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGR 293
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 260-310 5.33e-09

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 52.20  E-value: 5.33e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 110626175  260 FCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKLNAGRGFsdiFEEE 310
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESSDPSIDL---FDEE 48
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 17-196 3.95e-70

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 226.31  E-value: 3.95e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    17 RICLCILSYLPWFEVYYKLLNTLADYLAKELEEDLnETLKSLYNHPVPKANTPVNLS-----VHSCFITPDITGLPTIPe 91
Cdd:smart00799   2 PKCICILSRLPFFELFRKILNELYRLLPSSSNLPL-ELLISLLLYPVPPPGGSLVLVslgpgDLIELQRPLDSSLPLID- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175    92 sRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 171
Cdd:smart00799  80 -FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIG 158

                          170       180
                   ....*....|....*....|....*
gi 110626175   172 IHSSLIERVKNKSLEDVVVLNVDTN 196
Cdd:smart00799 159 VHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 19-196 2.21e-46

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 162.74  E-value: 2.21e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175   19 CLCILSYLPWFEVYYKLLNTLADYLAKELEEDLNETL--KSLYNHPVPKANTPVNLSVHS-----CFITPDITGLPTipE 91
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFiaNLLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL--E 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110626175   92 SRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 171
Cdd:pfam02141  83 GVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIG 162

                         170       180
                  ....*....|....*....|....*
gi 110626175  172 IHSSLIErVKNKSLEDVVVLNVDTN 196
Cdd:pfam02141 163 VHSRYFD-LLEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 228-293 1.36e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 83.11  E-value: 1.36e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110626175   228 GDGVARAFLRAQAALFGSYRDALRY---KPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGR 293
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 260-310 5.33e-09

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 52.20  E-value: 5.33e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 110626175  260 FCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKLNAGRGFsdiFEEE 310
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESSDPSIDL---FDEE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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