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Conserved domains on  [gi|126432554|ref|NP_849222|]
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protein arginine N-methyltransferase 6 [Mus musculus]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
54-231 1.59e-46

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  54 YSDVSVHEEMIADQVRTEAYRLGILKnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRLNGL 132
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554 133 EDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWS 212
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....*....
gi 126432554 213 QvkqhYGVDMSCMESFATR 231
Cdd:COG4076  164 F----DGFDFRLFGFLLYA 178
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
54-231 1.59e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  54 YSDVSVHEEMIADQVRTEAYRLGILKnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRLNGL 132
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554 133 EDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWS 212
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....*....
gi 126432554 213 QvkqhYGVDMSCMESFATR 231
Cdd:COG4076  164 F----DGFDFRLFGFLLYA 178
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 89-185 1.07e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   89 VLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRLNGLedRVHVLPGPVETVELP-ERVDAIVSeWMGYGLLH 166
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLP 77

                          90
                  ....*....|....*....
gi 126432554  167 ESMLSSVLHARTKWLKEGG 185
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-188 1.62e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  88 TVLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREvVRLNGLEDRVHVLPGPVETVEL--PERVDAIVSEWMGYGL 164
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVaLELARK-AAAALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 126432554 165 LHEsmLSSVLHARTKWLKEGGLLL 188
Cdd:cd02440   80 VED--LARFLEEARRLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
84-141 2.91e-10

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 60.17  E-value: 2.91e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126432554  84 LRGKTVLDVGAGTGILSIFCAQAGARRVYAV---EAsAIwQQAREVVRLNGLEDRVHVLPG 141
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVdidPQ-AV-EAARENAELNGVELNVYLPQG 176
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 88-140 2.88e-07

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 49.23  E-value: 2.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 126432554   88 TVLDVGAGTGILSIFCAQAGAR-RVYAVEASA-IWQQAREVVRLNGLEDrVHVLP 140
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLPdAYEILEENVKLNNLPN-VVLLN 54
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
54-231 1.59e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  54 YSDVSVHEEMIADQVRTEAYRLGILKnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRLNGL 132
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554 133 EDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWS 212
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....*....
gi 126432554 213 QvkqhYGVDMSCMESFATR 231
Cdd:COG4076  164 F----DGFDFRLFGFLLYA 178
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 82-188 2.54e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.89  E-value: 2.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  82 AALRGKTVLDVGAGTGILSIFCAQAGArRVYAVEASAiwqQAREVVRLNGLEDRVHVLPGPVETVELP-ERVDAIVSewm 160
Cdd:COG2227   21 LLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISP---EALEIARERAAELNVDFVQGDLEDLPLEdGSFDLVIC--- 93

                         90       100
                 ....*....|....*....|....*...
gi 126432554 161 GYGLLHESMLSSVLHARTKWLKEGGLLL 188
Cdd:COG2227   94 SEVLEHLPDPAALLRELARLLKPGGLLL 121
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
83-156 6.45e-14

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 71.36  E-value: 6.45e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126432554  83 ALRGKTVLDVGAGTGILSIFCAQAGARRVYAV--EASAIwQQAREVVRLNGLEDRVHVLPGPVETvelPERVDAIV 156
Cdd:COG2264  146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVdiDPVAV-EAARENAELNGVEDRIEVVLGDLLE---DGPYDLVV 217
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 71-157 2.87e-13

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 68.63  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  71 EAYRLGI----LKNWAALR-GKTVLDVGAGTGILSIFCAQ-AGARRVYAVEA-SAIWQQAREVVRLNGLEDRVHVLPGPV 143
Cdd:COG4123   18 CGYRFGTdavlLAAFAPVKkGGRVLDLGTGTGVIALMLAQrSPGARITGVEIqPEAAELARRNVALNGLEDRITVIHGDL 97

                         90
                 ....*....|....*..
gi 126432554 144 ETVE---LPERVDAIVS 157
Cdd:COG4123   98 KEFAaelPPGSFDLVVS 114
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
64-157 3.26e-13

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 67.62  E-value: 3.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  64 IADQVRTEAYRLGILKnwaalrGKTVLDVGAGTGILSIFCAQAGARRVYAVEasaIWQQAREVVRLN--GLEDRVHVLPG 141
Cdd:COG2263   30 LAAELLHLAYLRGDIE------GKTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIARENaeRLGVRVDFIRA 100

                         90
                 ....*....|....*.
gi 126432554 142 PVETVELPERVDAIVS 157
Cdd:COG2263  101 DVTRIPLGGSVDTVVM 116
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 86-188 5.47e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 66.11  E-value: 5.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  86 GKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwQQ---AREVVRLNGLEDRVHVLPGPVETVELPERVDAIVS----E 158
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRYGVRVTGVTLSP--EQleyARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSigmfE 129

                         90       100       110
                 ....*....|....*....|....*....|
gi 126432554 159 WMGYGLLHESMlsSVLHArtkWLKEGGLLL 188
Cdd:COG2230  130 HVGPENYPAYF--AKVAR---LLKPGGRLL 154
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 89-185 1.07e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   89 VLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRLNGLedRVHVLPGPVETVELP-ERVDAIVSeWMGYGLLH 166
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLP 77

                          90
                  ....*....|....*....
gi 126432554  167 ESMLSSVLHARTKWLKEGG 185
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 88-188 1.62e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.52  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  88 TVLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREvVRLNGLEDRVHVLPGPVETVEL--PERVDAIVSEWMGYGL 164
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVaLELARK-AAAALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 126432554 165 LHEsmLSSVLHARTKWLKEGGLLL 188
Cdd:cd02440   80 VED--LARFLEEARRLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
84-141 2.91e-10

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 60.17  E-value: 2.91e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126432554  84 LRGKTVLDVGAGTGILSIFCAQAGARRVYAV---EAsAIwQQAREVVRLNGLEDRVHVLPG 141
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVdidPQ-AV-EAARENAELNGVELNVYLPQG 176
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-210 1.41e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 53.07  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  77 ILKNWAALRGKTVLDVGAGTGILSIFCAQAGArRVYAVEAS-AIWQQAREvvRLNGLEDRVHVLPGPVETVELP-ERVDA 154
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPdGSFDL 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554 155 IVSewmGYGLLHESMLSSVLH--ARTkwLKEGGLLLpaSAElFVAPISDQMLEW--RLGF 210
Cdd:COG2226   91 VIS---SFVLHHLPDPERALAeiARV--LKPGGRLV--VVD-FSPPDLAELEELlaEAGF 142
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 85-188 2.80e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.38  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  85 RGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRLNGLeDRVHVLPGPV-ETVELP-ERVDAIVSewm 160
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSpeAI-ALARARAAKAGL-GNVEFLVADLaELDPLPaESFDLVVA--- 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 126432554 161 gYGLLH---ESMLSSVLHARTKWLKEGGLLL 188
Cdd:COG0500  101 -FGVLHhlpPEEREALLRELARALKPGGVLL 130
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 86-156 3.03e-08

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 54.58  E-value: 3.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126432554   86 GKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRLNGLEDRVHV-LPGpvetvELPER-VDAIV 156
Cdd:pfam06325 162 GESVLDVGCGSGILAIAALKLGAKKVVGVDIDpvAV-RAAKENAELNGVEARLEVyLPG-----DLPKEkADVVV 230
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 90-188 4.29e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.36  E-value: 4.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   90 LDVGAGTGILSIFCAQAGArRVYAVEasaIWQQAREVVRLNGLEDRVHVLPGPVETVELP-ERVDAIVSEWMgygLLHES 168
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPdNSFDLVLSSEV---LHHVE 73

                          90       100
                  ....*....|....*....|
gi 126432554  169 MLSSVLHARTKWLKEGGLLL 188
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
85-188 6.47e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.21  E-value: 6.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  85 RGKTVLDVGAGTGILS-IFCAQAGARRVYAVEASA--IwQQAREVVrlngleDRVHVLPGPVETVELPERVDAIVS---- 157
Cdd:COG4106    1 PPRRVLDLGCGTGRLTaLLAERFPGARVTGVDLSPemL-ARARARL------PNVRFVVADLRDLDPPEPFDLVVSnaal 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 126432554 158 EWMGyglLHESMLSSVLHArtkwLKEGGLLL 188
Cdd:COG4106   74 HWLP---DHAALLARLAAA----LAPGGVLA 97
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 81-156 1.70e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 52.49  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  81 WAALRG-KTVLDVGAGTGILSIFCAQAgARRVYAVE--ASAIwQQAREVVRLNGLeDRVHVLPGPVETV----ELPERVD 153
Cdd:COG2265  228 WLDLTGgERVLDLYCGVGTFALPLARR-AKKVIGVEivPEAV-EDARENARLNGL-KNVEFVAGDLEEVlpelLWGGRPD 304


                 ...
gi 126432554 154 AIV 156
Cdd:COG2265  305 VVV 307
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 84-138 1.88e-07

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 51.42  E-value: 1.88e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 126432554  84 LRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwqQAREVVRLNGLEDRVHV 138
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDP---EALAALRLNAALNGVAI 120
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 88-140 2.88e-07

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 49.23  E-value: 2.88e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 126432554   88 TVLDVGAGTGILSIFCAQAGAR-RVYAVEASA-IWQQAREVVRLNGLEDrVHVLP 140
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLPdAYEILEENVKLNNLPN-VVLLN 54
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 78-157 3.19e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 50.19  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  78 LKNWAALRGKTVLDVGAGTGILSIFCAQAGA-RRVYAVEAS--AIwQQAREVVRLNGLEDrVHVLPGPV-ETVElPERVD 153
Cdd:COG2813   42 LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPeARVTLVDVNarAV-ELARANAAANGLEN-VEVLWSDGlSGVP-DGSFD 118


                 ....
gi 126432554 154 AIVS 157
Cdd:COG2813  119 LILS 122
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 77-157 3.97e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 50.92  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  77 ILKNWAALRGKTVLDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIwQQAREVVRLNGLEDRVHVLPGPV-ETVELPERV 152
Cdd:COG2890  104 ALALLPAGAPPRVLDLGTGSGAIALALAKERPDaRVTAVDISpdAL-AVARRNAERLGLEDRVRFLQGDLfEPLPGDGRF 182


                 ....*
gi 126432554 153 DAIVS 157
Cdd:COG2890  183 DLIVS 187
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
77-188 4.99e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 49.61  E-value: 4.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  77 ILKNWAALRGKTVLDVGAGTGILSIFCAQAGaRRVYAVEASAiwqQAREVVRLNGLEDRVHVLpGPVETVELPERVDAIV 156
Cdd:COG4976   38 LLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSE---EMLAKAREKGVYDRLLVA-DLADLAEPDGRFDLIV 112

                         90       100       110
                 ....*....|....*....|....*....|..
gi 126432554 157 SeWMGYGLLHEsmLSSVLHARTKWLKEGGLLL 188
Cdd:COG4976  113 A-ADVLTYLGD--LAAVFAGVARALKPGGLFI 141
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 78-157 5.88e-07

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 49.13  E-value: 5.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   78 LKNWAALRGKTVLDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIWqQAREVVRLNGLEDrVHVLPGPV-ETVElPERVD 153
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDaELTMVDINarALE-SARENLAANGLEN-GEVVASDVySGVE-DGKFD 100


                  ....
gi 126432554  154 AIVS 157
Cdd:pfam05175 101 LIIS 104
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 85-156 1.25e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 49.79  E-value: 1.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126432554  85 RGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRLNGLEDRVHVLPGPV-----ETVELPERVDAIV 156
Cdd:COG1092  216 KGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSatAL-EWAKENAALNGLDDRHEFVQADAfdwlrELAREGERFDLII 293
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 60-146 1.63e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 48.68  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  60 HEEMIADQvrteayrLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGArRVYAVE-ASAIWQQAREVVRLNGLEDRVHV 138
Cdd:PRK07580  45 HQRMRDTV-------LSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDiSPQMVEEARERAPEAGLAGNITF 116


                 ....*...
gi 126432554 139 LPGPVETV 146
Cdd:PRK07580 117 EVGDLESL 124
PRK14968 PRK14968
putative methyltransferase; Provisional
 86-164 1.76e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 47.97  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  86 GKTVLDVGAGTGILSIFCAQAGARRV------YAVEasaiwqQAREVVRLNGLEDR-VHVL---------PGPVETV--- 146
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKKVVgvdinpYAVE------CAKCNAKLNNIRNNgVEVIrsdlfepfrGDKFDVIlfn 97

                         90       100
                 ....*....|....*....|
gi 126432554 147 --ELPERVDAIVSEWMGYGL 164
Cdd:PRK14968  98 ppYLPTEEEEEWDDWLNYAL 117
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 65-187 2.81e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 47.38  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  65 ADQVRtEAyrlgiLKNW--AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwqQAREVVRLN----GLEDRVHV 138
Cdd:COG0742   25 TDRVR-EA-----LFNIlgPDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDR---KAAAVIRKNleklGLEDRARV 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 126432554 139 LPGPVETV---ELPERVDAIvsewmgygLL----HESMLSSVLHA--RTKWLKEGGLL 187
Cdd:COG0742   96 IRGDALRFlkrLAGEPFDLV--------FLdppyAKGLLEKALELlaENGLLAPGGLI 145
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
82-156 9.37e-06

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 46.82  E-value: 9.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  82 AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA--IWqqareVVRLN----GLED-RVHVLPGPVETV--ELP-ER 151
Cdd:COG2521  129 GVRRGDRVLDTCTGLGYTAIEALKRGAREVITVEKDPnvLE-----LAELNpwsrELANeRIKIILGDASEVikTFPdES 203


                 ....*
gi 126432554 152 VDAIV 156
Cdd:COG2521  204 FDAII 208
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
66-138 1.41e-05

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 45.31  E-value: 1.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126432554   66 DQVRtEAyrlgiLKNW--AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA-REVVRLNGLEDRVHV 138
Cdd:pfam03602  26 DRVR-EA-----LFNWlaPYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQIlKENLQLLGLPGAVLV 95
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 82-188 4.08e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 43.63  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  82 AALRGKTVLDVGAGTGILSIFCAQAGAR--RVYAVEASAIWQQ-AREVVRLNGLEDRVHVLPGPVETV--ELPER----- 151
Cdd:COG4122   13 RLLGAKRILEIGTGTGYSTLWLARALPDdgRLTTIEIDPERAAiARENFARAGLADRIRLILGDALEVlpRLADGpfdlv 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 126432554 152 -VDAIVSEWMGYglLHESMlssvlhartKWLKEGGLLL 188
Cdd:COG4122   93 fIDADKSNYPDY--LELAL---------PLLRPGGLIV 119
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 45-161 8.21e-05

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 42.58  E-value: 8.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   45 ERDQLYYECYsdvsvhEEMIadqvrtEAYRLGILKNWAALRGKTV-LDVGAGTGIL---SIFCAQAGAR--RVYAVEA-- 116
Cdd:pfam05185  34 EKDPVKYDLY------ERAI------EKALSDRVPEKKKTSKLLViLVVGAGRGPLvdrALRAAEETGTkvKIYAVEKnp 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 126432554  117 SAIWQ-QARevVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMG 161
Cdd:pfam05185 102 NAYVTlQKR--INFEKWGDKVTIISSDMREWQGPEKADILVSELLG 145
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 85-210 1.48e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.86  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  85 RGKTVLDVGAGTGILSIFCAQAGaRRVYAVEASAIW-QQAREVVRLNGLEDrVHVLPGPVETVELP-ERVDAIVSEwMGY 162
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLG-RRVIGSDIDPKMvEGARENLEHYGYED-ADVIRGDARDLPLAdESVDAIVTD-PPY 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 126432554 163 GLLH-------ESMLSSVLHARTKWLKEGGLLlpasaeLFVAPISDQMLEWRLGF 210
Cdd:COG1041  103 GRSSkisgeelLELYEKALEEAARVLKPGGRV------VIVTPRDIDELLEEAGF 151
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 77-157 1.62e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 42.84  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  77 ILKNWAALRGKTVLDVGAGTGILSI----FCAQAgarRVYAVEASAiwqQAREVVRLN---GLEDRVHVLPGPVETVELP 149
Cdd:PRK09328 100 ALEALLLKEPLRVLDLGTGSGAIALalakERPDA---EVTAVDISP---EALAVARRNakhGLGARVEFLQGDWFEPLPG 173


                 ....*...
gi 126432554 150 ERVDAIVS 157
Cdd:PRK09328 174 GRFDLIVS 181
PRK14967 PRK14967
putative methyltransferase; Provisional
 86-137 1.63e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 42.73  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 126432554  86 GKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRLNGLEDRVH 137
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISrrAV-RSARLNALLAGVDVDVR 89
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 86-156 1.81e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 42.45  E-value: 1.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126432554  86 GKTVLDVGAGTGILSIFCAQA----GarRVYAVEASAIWQ-QAREVVRLNGLEDRVHVLPGPVETVELPERVDAIV 156
Cdd:COG2519   92 GARVLEAGTGSGALTLALARAvgpeG--KVYSYERREDFAeIARKNLERFGLPDNVELKLGDIREGIDEGDVDAVF 165
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 86-187 3.15e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 42.16  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  86 GKTVLDVGAGTGILSIFCAQAGARRVYAVEA--SAIwQQAREVVRLNGLEDRVHVLPGPVETV--ELPERVDAIVsewMG 161
Cdd:COG2520  181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDInpDAV-EYLKENIRLNKVEDRVTPILGDAREVapELEGKADRII---MN 256

                         90       100
                 ....*....|....*....|....*..
gi 126432554 162 Y-GLLHESMLSSVLHartkwLKEGGLL 187
Cdd:COG2520  257 LpHSADEFLDAALRA-----LKPGGVI 278
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 90-187 3.42e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 39.27  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   90 LDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSewmgYGLLH 166
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGlEYTGLDISpaALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVA----SNVLH 76

                          90       100
                  ....*....|....*....|..
gi 126432554  167 E-SMLSSVLHARTKWLKEGGLL 187
Cdd:pfam08242  77 HlADPRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 69-188 4.46e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.49  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   69 RTEAYRLGILKNWAALR-GKTVLDVGAGTGILSIFCAQAGArRVYAVEASAIWQQAREVVRLNGLEDRVHVLPgpvetve 147
Cdd:pfam13489   5 RERLLADLLLRLLPKLPsPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFDEQEAAV------- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 126432554  148 LPERVDAIVSeWMGYGLLHEsmLSSVLHARTKWLKEGGLLL 188
Cdd:pfam13489  77 PAGKFDVIVA-REVLEHVPD--PPALLRQIAALLKPGGLLL 114
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 85-114 9.17e-04

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 39.88  E-value: 9.17e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 126432554   85 RGKTVLDVGAGTGILSIFCAQAGARRVYAV 114
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQVALQRGAGKVVGV 50
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
 84-114 9.78e-04

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 40.43  E-value: 9.78e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 126432554  84 LRGKTVLDVGAGTGIlsiF--CA-QAGARRVYAV 114
Cdd:COG1189   76 VAGKVCLDIGASTGG---FtdCLlQRGAAKVYAV 106
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 86-157 1.14e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.39  E-value: 1.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126432554   86 GKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQ-QAREVVRLNGLEDRVHVLPGPVEtvELPERVDAIVS 157
Cdd:pfam02353  62 GMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYkLARKRVAAEGLARKVEVLLQDYR--DFDEPFDRIVS 132
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 75-157 1.40e-03

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 39.75  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554  75 LGILKnWAALRGKTVLDVGAGTG----ILSIFCAQagaRRVYAVEAS---AIWQqaREVVRLNGLEDrVHVLPGPVETVE 147
Cdd:COG0357   58 LALLP-LLPKEGARVLDVGSGAGfpgiPLAIARPD---LQVTLVDSLgkkIAFL--REVVRELGLKN-VTVVHGRAEELA 130

                         90
                 ....*....|
gi 126432554 148 LPERVDAIVS 157
Cdd:COG0357  131 PREKFDVVTA 140
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 90-188 1.95e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 37.29  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   90 LDVGAGTGILSIFCAQA----GARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVeLPERVDAivsewmGYGLL 165
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAAlrdnGLGRLTAVDPDPGAEEAGALLRKAGLDDRVRLIVGDSREA-LPSLADG------PIDLL 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 126432554  166 H-------ESMLSSVLHARtKWLKEGGLLL 188
Cdd:pfam13578  74 FidgdhtyEAVLNDLELWL-PRLAPGGVIL 102
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 85-191 2.54e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 37.69  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   85 RGKTVLDVGAGTGILSIFCA-QAGARRVYAVEASAiwqQAREVVRLNG---LEDRVHVLPG--PVETVELPERVDAIVSE 158
Cdd:TIGR02469  19 PGDVLWDIGAGTGSVTIEAArLVPNGRVYAIERNP---EALDLIERNLrrfGVSNIVIVEGdaPEAPEALLPDPDAVFVG 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 126432554  159 WMGyGLLHEsmlssVLHARTKWLKEGG-LLLPAS 191
Cdd:TIGR02469  96 GSG-GLLQE-----ILEAVERRLRPGGrIVLNAI 123
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 82-141 2.91e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 39.38  E-value: 2.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126432554  82 AALR---GKTVLDVGAGTGILSIFCAQAGAR-RVYAVEASAiwqQAREVVRLN----GLeDRVHVLPG 141
Cdd:COG2242  241 AKLAlrpGDVLWDIGAGSGSVSIEAARLAPGgRVYAIERDP---ERAALIRANarrfGV-PNVEVVEG 304
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 75-119 2.91e-03

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 39.07  E-value: 2.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 126432554  75 LGILKNWAALRGKTVLDVGAGTGILSIFCAQAGArrvyAVEASAI 119
Cdd:PLN02585 134 LLWLAEDGSLAGVTVCDAGCGTGSLAIPLALEGA----IVSASDI 174
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 75-218 5.72e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 38.04  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126432554   75 LGILKNWAALRGKTVLDVGAGTGILSIFCAQAG-ARRVYAVEASAIW-QQAREVVRLNgledrVHVLPGPVETVELPER- 151
Cdd:TIGR02072  24 LALLKEKGIFIPASVLDIGCGTGYLTRALLKRFpQAEFIALDISAGMlAQAKTKLSEN-----VQFICGDAEKLPLEDSs 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126432554  152 VDAIVS----EWmgyglLHEsmLSSVLHARTKWLKEGGLLlpasaeLFVAPISDQMLEWRlGFWSQVKQHY 218
Cdd:TIGR02072  99 FDLIVSnlalQW-----CDD--LSQALSELARVLKPGGLL------AFSTFGPGTLHELR-QSFGQHGLRY 155
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
85-155 9.59e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 36.90  E-value: 9.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126432554  85 RGKTVLDVGAGTGILSIfcaQAgARRVYAVEASAIWQQ--AREVVRLN----GLEDrVHVLPGpVETVELPERVDAI 155
Cdd:PRK08287  31 RAKHLIDVGAGTGSVSI---EA-ALQFPSLQVTAIERNpdALRLIKENrqrfGCGN-IDIIPG-EAPIELPGKADAI 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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