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Conserved domains on  [gi|86990456|ref|NP_849161|]
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leucine-rich repeat transmembrane neuronal protein 1 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886  56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886 129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886 278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 86990456 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886 358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886  56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886 129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886 278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 86990456 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886 358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.20e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 112 LRRVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDL---VKVNFAhfPRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGN 266
Cdd:cd21340  73 LYLGGNRISVV--EGLENLTNLEELHIENQRLppgEKLTFD--PRSLAALSNSLRV------------------LNISGN 130

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 86990456 267 EIEYMEPhvFETVPHLQSLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340 131 NIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.38e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86990456   113 RRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 7.71e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 7.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLV-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113 387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 86990456  247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113 466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR smart00370
Leucine-rich repeats, outliers;
136-159 5.26e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 86990456    136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886  56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886 129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886 278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 86990456 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886 358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.20e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 112 LRRVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDL---VKVNFAhfPRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGN 266
Cdd:cd21340  73 LYLGGNRISVV--EGLENLTNLEELHIENQRLppgEKLTFD--PRSLAALSNSLRV------------------LNISGN 130

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 86990456 267 EIEYMEPhvFETVPHLQSLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340 131 NIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.38e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86990456   113 RRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
90-149 6.35e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 6.35e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456    90 QLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKL 149
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-221 2.22e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86990456   161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 7.71e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 7.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLV-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113 387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 86990456  247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113 466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-293 3.38e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   90 QLTWLYLDHNHICSV----QGDafqklrrVKELTLSSNQITQLPNTtfrpMPN-LRSVDLSYNKLQALAPDLFHGLRKLT 164
Cdd:PRK15370 200 QITTLILDNNELKSLpenlQGN-------IKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  165 TLHmraNAIQFVPVRIFQDcrsLKFLDIGYNQLKSLARNSFAGlfkLTELHLEHNDLVKVNfAHFPrlISLHSLCLRRNK 244
Cdd:PRK15370 269 LFH---NKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALP-ETLP--PGLKTLEAGENA 336

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 86990456  245 VAIVVSSLDwvWNLEKMDLSGNEIEYMEphvfETV-PHLQSLQLDSNRLT 293
Cdd:PRK15370 337 LTSLPASLP--PELQVLDVSKNQITVLP----ETLpPTITTLDVSRNALT 380
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-192 5.95e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 5.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  75 NSLSELRagQFTGLMQLTWLYLDHNHICSVQGdaFQKLRRVKELTLsSNQitQLPNT---TFRPM------PNLRSVDLS 145
Cdd:cd21340  56 NQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ--RLPPGeklTFDPRslaalsNSLRVLNIS 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 86990456 146 YNKLQALAPdlFHGLRKLTTLHMRANAIQ-FVPV-RIFQDCRSLKFLDI 192
Cdd:cd21340 129 GNNIDSLEP--LAPLRNLEQLDASNNQISdLEELlDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
73-125 7.63e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 7.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 86990456    73 RYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQI 125
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
257-315 1.75e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 86990456   257 NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-235 1.40e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   96 LDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQF 175
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSG 489

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 86990456  176 VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL---VKVNFAHFPRLISL 235
Cdd:PLN00113 490 AVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLsgqIPASFSEMPVLSQL 552
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-285 3.85e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 3.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  86 TGLMQLTWLYLDHNHI----CSVQGDAFQKLRRVKELTLSSNQIT----QLPNTTFRPMPNLRSVDLSYNKL-----QAL 152
Cdd:COG5238 233 KGNKSLTTLDLSNNQIgdegVIALAEALKNNTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIgdegaIAL 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 153 APdlfhGLRKLTTLHMranaiqfvpvrifqdcrslkfLDIGYNQL-----KSLARNsFAGLFKLTELHLEHN---DLVKV 224
Cdd:COG5238 313 AE----GLQGNKTLHT---------------------LNLAYNGIgaqgaIALAKA-LQENTTLHSLDLSDNqigDEGAI 366

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 86990456 225 NFAHFPRLI-SLHSLCLRRNKV----AIVVSSLDWVWNLEKMDLSGNEIEY-MEPHVFETVPHLQSL 285
Cdd:COG5238 367 ALAKYLEGNtTLRELNLGKNNIgkqgAEALIDALQTNRLHTLILDGNLIGAeAQQRLEQLLERIKSV 433
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-228 6.29e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 6.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   75 NSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQIT-QLPNTtFRPmPNLRSVDLSYNKLQALA 153
Cdd:PLN00113 414 NSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDS-FGS-KRLENLDLSRNQFSGAV 491

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  154 PDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHND------------- 220
Cdd:PLN00113 492 PRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQlsgeipknlgnve 571


                 ....*....
gi 86990456  221 -LVKVNFAH 228
Cdd:PLN00113 572 sLVQVNISH 580
LRR_8 pfam13855
Leucine rich repeat;
234-292 6.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 6.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 86990456   234 SLHSLCLRRNKVaivvSSLDWVW-----NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRL 292
Cdd:pfam13855   2 NLRSLDLSNNRL----TSLDDGAfkglsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-221 9.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 9.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   90 QLTWLYLDHNHICSVQGDAFQKlRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMR 169
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 86990456  170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-314 2.26e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   99 NHICSVQGDAFQKLRRVKELTLSSNQIT-QLPNTTFRpMPNLRSVDLSYNKLQALAP-DLFHGLRKLTTLHMRANAIQ-- 174
Cdd:PLN00113  55 ADVCLWQGITCNNSSRVVSIDLSGKNISgKISSAIFR-LPYIQTINLSNNQLSGPIPdDIFTTSSSLRYLNLSNNNFTgs 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  175 ----FVPV-------------RIFQDC---RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLIS 234
Cdd:PLN00113 134 iprgSIPNletldlsnnmlsgEIPNDIgsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  235 LHSLCLRRNKVA----------IVVSSLDWVWNlekmDLSGnEIeymePHVFETVPHLQSLQLDSNRLTYIEPRILNSWK 304
Cdd:PLN00113 214 LKWIYLGYNNLSgeipyeigglTSLNHLDLVYN----NLTG-PI----PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ 284

                        250
                 ....*....|
gi 86990456  305 SLTSITLAGN 314
Cdd:PLN00113 285 KLISLDLSDN 294
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-268 1.26e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456  85 FTGLMQLTWLYLDHNHICSVQGDAFQKLRR---VKELTLSSN----QITQLPNTTFR-PMPNLRSVDLSYNKL-----QA 151
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNglgdRGLRLLAKGLKdLPPALEKLVLGRNRLegascEA 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456 152 LApDLFHGLRKLTTLHMRANAIQF----VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK----LTELHLEHNDLVK 223
Cdd:cd00116 157 LA-KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTD 235

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 86990456 224 VNFAHF-----PRLISLHSLCLRRNKVAI-----VVSSLDWVWNLEKMDLSGNEI 268
Cdd:cd00116 236 AGAAALasallSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
185-245 2.99e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.99e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86990456   185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKV 245
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
107-210 3.78e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   107 DAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAP-DLFHGLRKLTTLHMRANAIQFVP---VRIFQ 182
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTNKPhyrLYVIY 137

                          90       100
                  ....*....|....*....|....*...
gi 86990456   183 DCRSLKFLDigYNQLKSLARNSFAGLFK 210
Cdd:pfam14580 138 KVPQLRLLD--FRKVKQKERQAAEKMFR 163
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 114-149 2.22e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 86990456   114 RVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKL 149
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-171 2.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 86990456   137 PNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRAN 171
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
 94-173 2.78e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86990456   94 LYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
280-315 2.99e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 86990456   280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL 36
LRR smart00370
Leucine-rich repeats, outliers;
136-159 5.26e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 86990456    136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
136-159 5.26e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 86990456    136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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