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Conserved domains on  [gi|84781800|ref|NP_848708|]
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capZ-interacting protein isoform a [Mus musculus]

Protein Classification

CAP-ZIP_m and RCSD domain-containing protein( domain architecture ID 11700656)

CAP-ZIP_m and RCSD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP-ZIP_m super family cl21113
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 75-166 2.39e-11

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


The actual alignment was detected with superfamily member pfam15255:

Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 61.00  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800    75 PPKIKvKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAIVspfhSPPSTPSSPGIRSHPSE-------AEEVPVSFDQP 147
Cdd:pfam15255   2 PFKTK-EPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVL----PGLAFPSSEPARSTSPEstptaqgSGEAGVSFDLP 76

                          90
                  ....*....|....*....
gi 84781800   148 PEGTHLPSYNKVRTRGSIK 166
Cdd:pfam15255  77 AQADTLHSANKSRAKVTGK 95
RCSD super family cl25618
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 230-315 2.10e-04

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


The actual alignment was detected with superfamily member pfam05177:

Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 40.41  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800   230 GTPWSAEKPRRRNTCNSTEKPEELVRTPEEANAGEKVGQNPDTASQGHP--EVQAPSQTGSPEAENGCGSPREETTPGEH 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKGRAPEEAEHSPKAVGGSEEEKPKSPakEEAVEAQASSPEAANGCGSPTEEKKAGEK 80


                  ....*...
gi 84781800   308 TDTGKATE 315
Cdd:pfam05177  81 VEEKKSSE 88
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 75-166 2.39e-11

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 61.00  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800    75 PPKIKvKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAIVspfhSPPSTPSSPGIRSHPSE-------AEEVPVSFDQP 147
Cdd:pfam15255   2 PFKTK-EPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVL----PGLAFPSSEPARSTSPEstptaqgSGEAGVSFDLP 76

                          90
                  ....*....|....*....
gi 84781800   148 PEGTHLPSYNKVRTRGSIK 166
Cdd:pfam15255  77 AQADTLHSANKSRAKVTGK 95
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 230-315 2.10e-04

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 40.41  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800   230 GTPWSAEKPRRRNTCNSTEKPEELVRTPEEANAGEKVGQNPDTASQGHP--EVQAPSQTGSPEAENGCGSPREETTPGEH 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKGRAPEEAEHSPKAVGGSEEEKPKSPakEEAVEAQASSPEAANGCGSPTEEKKAGEK 80


                  ....*...
gi 84781800   308 TDTGKATE 315
Cdd:pfam05177  81 VEEKKSSE 88
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
 75-166 2.39e-11

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 61.00  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800    75 PPKIKvKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAIVspfhSPPSTPSSPGIRSHPSE-------AEEVPVSFDQP 147
Cdd:pfam15255   2 PFKTK-EPSSRIGKLQANLAINPAALLPGAAPQIPGAKSVL----PGLAFPSSEPARSTSPEstptaqgSGEAGVSFDLP 76

                          90
                  ....*....|....*....
gi 84781800   148 PEGTHLPSYNKVRTRGSIK 166
Cdd:pfam15255  77 AQADTLHSANKSRAKVTGK 95
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
 230-315 2.10e-04

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 40.41  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781800   230 GTPWSAEKPRRRNTCNSTEKPEELVRTPEEANAGEKVGQNPDTASQGHP--EVQAPSQTGSPEAENGCGSPREETTPGEH 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKGRAPEEAEHSPKAVGGSEEEKPKSPakEEAVEAQASSPEAANGCGSPTEEKKAGEK 80


                  ....*...
gi 84781800   308 TDTGKATE 315
Cdd:pfam05177  81 VEEKKSSE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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