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Conserved domains on  [gi|29570800|ref|NP_817089|]
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cadherin-like protein 26 isoform a precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-271 4.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.14e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 169 EFNITVQENQSAGQPIFQMLAVDLDEEntPNSQVLYFLISQTPllkESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRAR 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 29570800 249 DCGEPSLSSTTTVHVDVQEGNNH 271
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 407-496 2.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 407 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 481
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 29570800 482 ATGTLMLFLSDINDN 496
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-392 5.49e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 280 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 357
Cdd:cd11304   2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29570800 358 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 392
Cdd:cd11304  75 TDGG----------GPPLS--STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 85-161 1.62e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.62e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29570800  85 NMSLMYLISGPGVDeypeiGLFSLeDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIfNIRISDVNDH 161
Cdd:cd11304  29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-271 4.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.14e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 169 EFNITVQENQSAGQPIFQMLAVDLDEEntPNSQVLYFLISQTPllkESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRAR 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 29570800 249 DCGEPSLSSTTTVHVDVQEGNNH 271
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 407-496 2.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 407 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 481
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 29570800 482 ATGTLMLFLSDINDN 496
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
170-266 1.40e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   170 FNITVQENQSAGQPIFQMLAVDLDEenTPNSQVLYFLISQTPLLKesgFRVDRLSGEIRLSGCLDYETAPQFTLLIRARD 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 29570800   250 CGEPSLSSTTTVHVDVQ 266
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 189-273 4.05e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 4.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    189 AVDLDEEntPNSQVLYFLISQTPLLKesgFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEG 268
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 29570800    269 NNHRP 273
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
406-486 6.72e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   406 EEGARPGTLLGTFNAMDPD----SQIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQ 480
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDlgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPL 81


                  ....*.
gi 29570800   481 TATGTL 486
Cdd:pfam00028  82 SSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-392 5.49e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 280 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 357
Cdd:cd11304   2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29570800 358 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 392
Cdd:cd11304  75 TDGG----------GPPLS--STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 419-498 1.06e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    419 NAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQTATGTLMLFLSDI 493
Cdd:smart00112   1 SATDADSgengKVTYSILsGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 29570800    494 NDNVP 498
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
280-388 3.27e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   280 YKVQIPEGRASQG-VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDISTDPetneGILNVIKPLDYETRPAQSLIIVVE 358
Cdd:pfam00028   1 YSASVPENAPVGTeVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 29570800   359 NEerlvfcergkLQPPRkaAASATVSVQVT 388
Cdd:pfam00028  75 DS----------GGPPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-394 8.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    298 VQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVVENEErlvfcergklQPPRka 377
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG----------GPPL-- 63

                           90
                   ....*....|....*..
gi 29570800    378 AASATVSVQVTDANDPP 394
Cdd:smart00112  64 SSTATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 85-161 1.62e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.62e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29570800  85 NMSLMYLISGPGVDeypeiGLFSLeDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIfNIRISDVNDH 161
Cdd:cd11304  29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.13e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.13e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29570800     85 NMSLMYLISGPGVDeypeiGLFSLeDHENGRIYVHRPVDREMTPSFTVYFdVVERSTGKIVDTSLIFNIRISDVNDHAP 163
Cdd:smart00112  10 NGKVTYSILSGNDD-----GLFSI-DPETGEITTTKPLDREEQPEYTLTV-EATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-271 4.14e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.14e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 169 EFNITVQENQSAGQPIFQMLAVDLDEEntPNSQVLYFLISQTPllkESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRAR 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 29570800 249 DCGEPSLSSTTTVHVDVQEGNNH 271
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 407-496 2.19e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 2.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 407 EGARPGTLLGTFNAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQT 481
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSgengEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 29570800 482 ATGTLMLFLSDINDN 496
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
170-266 1.40e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   170 FNITVQENQSAGQPIFQMLAVDLDEenTPNSQVLYFLISQTPLLKesgFRVDRLSGEIRLSGCLDYETAPQFTLLIRARD 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN---FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 29570800   250 CGEPSLSSTTTVHVDVQ 266
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 189-273 4.05e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 4.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    189 AVDLDEEntPNSQVLYFLISQTPLLKesgFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEG 268
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGL---FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 29570800    269 NNHRP 273
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
406-486 6.72e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   406 EEGARPGTLLGTFNAMDPD----SQIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQ 480
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDlgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPL 81


                  ....*.
gi 29570800   481 TATGTL 486
Cdd:pfam00028  82 SSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 280-392 5.49e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 5.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800 280 YKVQIPEGrASQG--VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVV 357
Cdd:cd11304   2 YEVSVPEN-APPGtvVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|....*
gi 29570800 358 ENEErlvfcergklQPPRKaaASATVSVQVTDAND 392
Cdd:cd11304  75 TDGG----------GPPLS--STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 419-498 1.06e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    419 NAMDPDS----QIRYELV-HDPANWVSVDKNSGVVITVEPIDRESphvnNSFYVIIIHAVDDGFPPQTATGTLMLFLSDI 493
Cdd:smart00112   1 SATDADSgengKVTYSILsGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 29570800    494 NDNVP 498
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
280-388 3.27e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.39  E-value: 3.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800   280 YKVQIPEGRASQG-VLRLLVQDRDSPftSAWRAKFNILHGNEEGHFDISTDPetneGILNVIKPLDYETRPAQSLIIVVE 358
Cdd:pfam00028   1 YSASVPENAPVGTeVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 29570800   359 NEerlvfcergkLQPPRkaAASATVSVQVT 388
Cdd:pfam00028  75 DS----------GGPPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-394 8.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29570800    298 VQDRDSPftSAWRAKFNILHGNEEGHFDIstDPETneGILNVIKPLDYETRPAQSLIIVVENEErlvfcergklQPPRka 377
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG----------GPPL-- 63

                           90
                   ....*....|....*..
gi 29570800    378 AASATVSVQVTDANDPP 394
Cdd:smart00112  64 SSTATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 85-161 1.62e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 46.92  E-value: 1.62e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29570800  85 NMSLMYLISGPGVDeypeiGLFSLeDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIfNIRISDVNDH 161
Cdd:cd11304  29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.13e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.13e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29570800     85 NMSLMYLISGPGVDeypeiGLFSLeDHENGRIYVHRPVDREMTPSFTVYFdVVERSTGKIVDTSLIFNIRISDVNDHAP 163
Cdd:smart00112  10 NGKVTYSILSGNDD-----GLFSI-DPETGEITTTKPLDREEQPEYTLTV-EATDGGGPPLSSTATVTITVLDVNDNAP 81
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 380-450 2.07e-03

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 38.09  E-value: 2.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29570800   380 SATVSVQVTDANDPPAFHPQSFIVNkeegarPGTLLGtfNAMDPD------SQIRYELVHDPAN-WVSVDKNSGVVIT 450
Cdd:pfam17963   1 TATVTVTVTPVNDAPVAVDDSVTVT------EDTVLA--NDSDPDgdpltiTSLTVTIVTAPANgTVTVNADGTLTYT 70
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 381-442 5.12e-03

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 36.39  E-value: 5.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29570800   381 ATVSVQVTDANDPPAFHPQSFIVNkEEGAR--PGTLLGtfNAMDPDSqiryelvhDPANWVSVD 442
Cdd:pfam17803   1 ATVTITVTGVNDAPVAVDDTATVD-EDTPVtiTGNVLA--NDTDVDG--------DTLTVTSVT 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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