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Conserved domains on  [gi|613410203|ref|NP_787069|]
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ankyrin repeat domain-containing protein SOWAHA precursor [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-438 2.31e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 346 GFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDHSGRRAYQY 425
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225

                         90
                 ....*....|...
gi 613410203 426 LRPGSSYALRRLL 438
Cdd:COG0666  226 AAENGNLEIVKLL 238
PHA03378 super family cl33729
EBNA-3B; Provisional
 93-234 2.38e-03

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203  93 FGPPGAAAQPSKP-TSTVLPRSASAPGAPPLVRVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGerSADPPLPALELA 171
Cdd:PHA03378 667 TQIGHIPYQPSPTgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG--RARPPAAAPGRA 744

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613410203 172 QATERPSADAAPPPRAPSEAASPCSDPPDAEPGPGAAKGP-PQQKP-----CMLPVRCVPAPATLRLRA 234
Cdd:PHA03378 745 RPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPaPQQRPrgaptPQPPPQAGPTSMQLMPRA 813
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-438 2.31e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 346 GFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDHSGRRAYQY 425
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225

                         90
                 ....*....|...
gi 613410203 426 LRPGSSYALRRLL 438
Cdd:COG0666  226 AAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
346-416 8.12e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 8.12e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613410203  346 GFTALHWAAKSGDGEMALQLVEVArrsgapvDVNARSHGgYTPLHLAALHGHEDaAVLLVVRLGAQVHVRD 416
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHA-------DVNLKDNG-RTALHYAARSGHLE-IVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 332-420 1.14e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 332 LRDRGLAAKRDFMSGFTALHWAAKSGDGEMAL--QLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHeDAAVLLVVRLG 409
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlPLLI------AGISINARNRYGQTPLHYAAVFNN-PRACRRLIALG 280

                         90
                 ....*....|.
gi 613410203 410 AQVHVRDHSGR 420
Cdd:PHA03095 281 ADINAVSSDGN 291
PHA03378 PHA03378
EBNA-3B; Provisional
 93-234 2.38e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203  93 FGPPGAAAQPSKP-TSTVLPRSASAPGAPPLVRVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGerSADPPLPALELA 171
Cdd:PHA03378 667 TQIGHIPYQPSPTgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG--RARPPAAAPGRA 744

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613410203 172 QATERPSADAAPPPRAPSEAASPCSDPPDAEPGPGAAKGP-PQQKP-----CMLPVRCVPAPATLRLRA 234
Cdd:PHA03378 745 RPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPaPQQRPrgaptPQPPPQAGPTSMQLMPRA 813
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 385-414 3.88e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.88e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 613410203   385 GYTPLHLAALHGHEDAAVLLvVRLGAQVHV 414
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLL-LDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-438 2.31e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 346 GFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDHSGRRAYQY 425
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDL 225

                         90
                 ....*....|...
gi 613410203 426 LRPGSSYALRRLL 438
Cdd:COG0666  226 AAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
345-422 3.20e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.45  E-value: 3.20e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613410203 345 SGFTALHWAAKSGDGEMALQLVEvarrSGApvDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLGAQVHVRDHSGRRA 422
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLE----AGA--DVNAQDNDGNTPLHLAAANGNLEIVKLL-LEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
330-422 8.79e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 8.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 330 LLLRDRGLAAKRDFMSGFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLvVRLG 409
Cdd:COG0666   71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLL-LEAG 143

                         90
                 ....*....|...
gi 613410203 410 AQVHVRDHSGRRA 422
Cdd:COG0666  144 ADVNAQDNDGNTP 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
346-416 8.12e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 8.12e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613410203  346 GFTALHWAAKSGDGEMALQLVEVArrsgapvDVNARSHGgYTPLHLAALHGHEDaAVLLVVRLGAQVHVRD 416
Cdd:pfam12796  30 GRTALHLAAKNGHLEIVKLLLEHA-------DVNLKDNG-RTALHYAARSGHLE-IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-438 1.22e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 346 GFTALHWAAKSGDGEMALQLVEvarrSGApvDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGRRAYQY 425
Cdd:COG0666  186 GETPLHLAAENGHLEIVKLLLE----AGA--DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                         90
                 ....*....|...
gi 613410203 426 LRPGSSYALRRLL 438
Cdd:COG0666  260 AAAGAALIVKLLL 272
Ank_4 pfam13637
Ankyrin repeats (many copies);
348-405 1.50e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 1.50e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 613410203  348 TALHWAAKSGDgemaLQLVEVARRSGApvDVNARSHGGYTPLHLAALHGHEDAAVLLV 405
Cdd:pfam13637   3 TALHAAAASGH----LELLRLLLEKGA--DINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
350-405 2.47e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 613410203  350 LHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLV 405
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLL 50
PHA03095 PHA03095
ankyrin-like protein; Provisional
 332-420 1.14e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 332 LRDRGLAAKRDFMSGFTALHWAAKSGDGEMAL--QLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHeDAAVLLVVRLG 409
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlPLLI------AGISINARNRYGQTPLHYAAVFNN-PRACRRLIALG 280

                         90
                 ....*....|.
gi 613410203 410 AQVHVRDHSGR 420
Cdd:PHA03095 281 ADINAVSSDGN 291
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
330-425 4.87e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.33  E-value: 4.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203 330 LLLRDRGLAAKRDFMSGFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVvRLG 409
Cdd:COG0666   38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLA------AGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAG 110

                         90
                 ....*....|....*.
gi 613410203 410 AQVHVRDHSGRRAYQY 425
Cdd:COG0666  111 ADVNARDKDGETPLHL 126
Ank_5 pfam13857
Ankyrin repeats (many copies);
375-425 2.63e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 2.63e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 613410203  375 PVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRlGAQVHVRDHSGRRAYQY 425
Cdd:pfam13857   6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDL 55
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 385-417 6.31e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 613410203  385 GYTPLHLAALH-GHEDAAVLLvVRLGAQVHVRDH 417
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLL-LSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
346-392 1.69e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 613410203  346 GFTALHWAAKSGDGEMALQLVEvarrsgAPVDVNARSHGGYTPLHLA 392
Cdd:pfam13857  16 GYTPLHVAAKYGALEIVRVLLA------YGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 385-422 1.89e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 1.89e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 613410203 385 GYTPLHLAALHGHEDaAVLLVVRLGAQVHVRDHSGRRA 422
Cdd:PLN03192 558 GRTPLHIAASKGYED-CVLVLLKHACNVHIRDANGNTA 594
PHA03378 PHA03378
EBNA-3B; Provisional
 93-234 2.38e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203  93 FGPPGAAAQPSKP-TSTVLPRSASAPGAPPLVRVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGerSADPPLPALELA 171
Cdd:PHA03378 667 TQIGHIPYQPSPTgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG--RARPPAAAPGRA 744

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 613410203 172 QATERPSADAAPPPRAPSEAASPCSDPPDAEPGPGAAKGP-PQQKP-----CMLPVRCVPAPATLRLRA 234
Cdd:PHA03378 745 RPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPaPQQRPrgaptPQPPPQAGPTSMQLMPRA 813
PHA03095 PHA03095
ankyrin-like protein; Provisional
 373-427 2.71e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 2.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 613410203 373 GApvDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGRRAYQ-YLR 427
Cdd:PHA03095  73 GA--DVNAPERCGFTPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvYLS 126
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
98-253 3.44e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203  98 AAAQPSKPTSTVLPRSASAPGAPPLVRVPRPVEPPGDlGLPTEPQDTPGGPASEPAQPPGERSADPPLPALELAQATERP 177
Cdd:PRK12323 395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPE-ALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVA 473

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613410203 178 SADAAPPPRAPSEAASPCSD--PPDAEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPGLRRQLSEEPSPRSSP 253
Cdd:PRK12323 474 AAAAAAPARAAPAAAPAPADddPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAP 551
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 385-414 3.88e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.88e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 613410203   385 GYTPLHLAALHGHEDAAVLLvVRLGAQVHV 414
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLL-LDKGADINA 30
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
99-238 7.52e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 7.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410203  99 AAQPSKPTSTVLPRSASAP---GAPPLVRVPRPVEPPgDLGLPTEPQDTPGGPASEPAQPPGERSADPPLPALELA-QAT 174
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAApvaQPAPAAAAPAAAAPA-PAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArQAS 440

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613410203 175 ERPSADAAPPPRAPSEAASPCSDPPDAEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPG 238
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP 504
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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