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Conserved domains on  [gi|30425352|ref|NP_780769|]
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zinc finger protein 747 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 1.05e-23

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.43  E-value: 1.05e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352     22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYLDVGCAKPALISWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-355 3.29e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 170 HMYTHTGEKPFqCPDCNKRFGRYSSLSTHRAIHRGER-PHQCPDCGKGFTQRCTLVAHM--YSHTGE--KPFQCP--DCN 242
Cdd:COG5048 252 DSSSSASESPR-SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCG 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 243 KCFGRYSSLSMHRAIHRGERPHQCP--DCGKGFTQ-----RCALVEHMYSHTGEKSFNC--PDCCKSFGRPSSLSRHRAI 313
Cdd:COG5048 331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 30425352 314 HLEERPH--RCSHCGKTFTQRSSLTSHLRVHTGEKPYCCADCGR 355
Cdd:COG5048 411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-408 9.47e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.47e-03
                          10
                  ....*....|....*...
gi 30425352   391 YLRRHMRIHTGEKPYSCP 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP 18
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 1.05e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.43  E-value: 1.05e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352     22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYLDVGCAKPALISWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-62 4.40e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.13  E-value: 4.40e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 30425352    22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYLD 62
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 22-61 1.13e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.13e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 30425352  22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYL 61
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-355 3.29e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 170 HMYTHTGEKPFqCPDCNKRFGRYSSLSTHRAIHRGER-PHQCPDCGKGFTQRCTLVAHM--YSHTGE--KPFQCP--DCN 242
Cdd:COG5048 252 DSSSSASESPR-SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCG 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 243 KCFGRYSSLSMHRAIHRGERPHQCP--DCGKGFTQ-----RCALVEHMYSHTGEKSFNC--PDCCKSFGRPSSLSRHRAI 313
Cdd:COG5048 331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 30425352 314 HLEERPH--RCSHCGKTFTQRSSLTSHLRVHTGEKPYCCADCGR 355
Cdd:COG5048 411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-189 7.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.66e-04
                          10        20
                  ....*....|....*....|...
gi 30425352   167 LEAHMYTHTGEKPFQCPDCNKRF 189
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-408 9.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.47e-03
                          10
                  ....*....|....*...
gi 30425352   391 YLRRHMRIHTGEKPYSCP 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP 18
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 1.05e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.43  E-value: 1.05e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352     22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYLDVGCAKPALISWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-62 4.40e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.13  E-value: 4.40e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 30425352    22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYLD 62
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 22-61 1.13e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.13e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 30425352  22 VSFADVAVYFSPEEWRYLRPAQRALYREVMRETYGLLTYL 61
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-355 3.29e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 3.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 170 HMYTHTGEKPFqCPDCNKRFGRYSSLSTHRAIHRGER-PHQCPDCGKGFTQRCTLVAHM--YSHTGE--KPFQCP--DCN 242
Cdd:COG5048 252 DSSSSASESPR-SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCG 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 243 KCFGRYSSLSMHRAIHRGERPHQCP--DCGKGFTQ-----RCALVEHMYSHTGEKSFNC--PDCCKSFGRPSSLSRHRAI 313
Cdd:COG5048 331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 30425352 314 HLEERPH--RCSHCGKTFTQRSSLTSHLRVHTGEKPYCCADCGR 355
Cdd:COG5048 411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-414 2.71e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 234 KPFQCPDCNKCFGRYSSLSMHR--AIHRGE--RPHQCP--DCGKGFTQRCALVEHMYSHTGEKSFNCP--DCCKSFGRPS 305
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 306 -----SLSRHRAIHLEERPHRCSH--CGKTFTQRSSLTSHLRVHTGEKPYCCadcgrcfsqrsrlhehqrvvhsgvtpfS 378
Cdd:COG5048 368 nneppQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC---------------------------K 420

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 30425352 379 CTHCGSAFADSKYLRRHMRIHTGEKPYSCPDWSLLS 414
Cdd:COG5048 421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-341 5.53e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 5.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 147 RADKRHGCHLCGKSFARRSTLEAHMYT--HTGE--KPFQCP--DCNKRFGRYSSLSTHRAIHRGERPHQCP--DCGKGFT 218
Cdd:COG5048 285 GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 219 Q-----RCTLVAHMYSHTGEKPFQC--PDCNKCFGRYSSLSMHRAIHRGERPHQCpdcgkgftqrcalvehmyshtgeks 291
Cdd:COG5048 365 PllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC------------------------- 419

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 30425352 292 fNCPDCCKSFGRPSSLSRHRAIHLEERPHRCSHCGKtFTQRSSLTSHLRV 341
Cdd:COG5048 420 -KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-408 2.20e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 152 HGCHLCGKSFARRSTLEAHMYTHTGEKPFQCPD--CNKRFGRYSSLSTHRAIHRGERPHQCPDCGKG------------- 216
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskasssslsss 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 217 --FTQRCTLVAHMYSHTGEKPFQ--------------CPDCN-------KCFGRYSSLSMHRAIHRGERPHQCPDCGKG- 272
Cdd:COG5048 114 ssNSNDNNLLSSHSLPPSSRDPQlpdllsisnlrnnpLPGNNsssvntpQSNSLHPPLPANSLSKDPSSNLSLLISSNVs 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 273 FTQRCALVEHMYSHTGEKSFNCPDcCKSFGRPSSLSRHRAIHLEER------------PHRCSHCGKTF-----TQRSSL 335
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSD-QNLENSSSSLPLTTNSQLSPKsllsqspsslssSDSSSSASESPrsslpTASSQS 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425352 336 TSHLRVHTGE-----KPYCCADCGRCFSQRSRLHEHQRVVH---SGVTPFSCTH--CGSAFADSKYLRRHMRIHTGEKPY 405
Cdd:COG5048 273 SSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352


                ...
gi 30425352 406 SCP 408
Cdd:COG5048 353 KEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-328 5.63e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.63e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30425352 262 RPHQCPDCGKGFTQRCALVEHMYSHTGEKSFNCPD--CCKSFGRPSSLSRHRAIHLEERPHRCSHCGKT 328
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-189 7.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.66e-04
                          10        20
                  ....*....|....*....|...
gi 30425352   167 LEAHMYTHTGEKPFQCPDCNKRF 189
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 320-342 1.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|...
gi 30425352   320 HRCSHCGKTFTQRSSLTSHLRVH 342
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-301 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 30425352   278 ALVEHMYSHTGEKSFNCPDCCKSF 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-275 4.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 30425352   250 SLSMHRAIHRGERPHQCPDCGKGFTQ 275
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-245 5.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.10e-03
                          10        20
                  ....*....|....*....|...
gi 30425352   223 LVAHMYSHTGEKPFQCPDCNKCF 245
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-219 6.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 30425352   194 SLSTHRAIHRGERPHQCPDCGKGFTQ 219
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 7.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 30425352   334 SLTSHLRVHTGEKPYCCADCGRCFSQ 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-408 9.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.47e-03
                          10
                  ....*....|....*...
gi 30425352   391 YLRRHMRIHTGEKPYSCP 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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