NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30425254|ref|NP_780708|]
View 

SLIT and NTRK-like protein 6 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 7.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886 140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425254 148 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886 217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 4.06e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886 115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30425254 468 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 516
Cdd:COG4886 192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.44e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 30425254    516 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
218-268 1.50e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.50e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425254    218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 7.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886 140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425254 148 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886 217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 4.06e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886 115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30425254 468 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 516
Cdd:COG4886 192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
387-444 4.86e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 4.86e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30425254   387 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYN 444
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-517 1.06e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 344 IHCQERNIESLSDLQPPPhNPRKLILAGNIIHTLmkSDLTDYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 423
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 424 KLnKGmFLGLHSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LQVLPAhiflgipLTRVNLKTN 491
Cdd:cd21340  82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                       170       180
                ....*....|....*....|....*..
gi 30425254 492 QFTHL-PVSNILDDLDFLIQIDLEDNP 517
Cdd:cd21340 153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
92-146 2.40e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30425254    92 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-199 1.64e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 141
Cdd:cd21340  50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30425254 142 QADNNFITIIEPsaFSKLNRLKVLILNDNAIESLP---PNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.44e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 30425254    516 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 1.50e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.50e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425254    218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 386-516 3.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  386 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKV 462
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30425254  463 LYLN-NNLLQVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDFLIQIDLEDN 516
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 7.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLHTnDFSGLTNALSIHLGFNNIADIeTGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886 140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425254 148 ITIIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886 217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-213 7.54e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 7.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  69 LSLLNNGLTMLhTNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEDtFHGLENLEFLQADNNFI 148
Cdd:COG4886 118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30425254 149 TIIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 213
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
388-516 4.06e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 388 LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlPGTFNPMPKLKVLYLNN 467
Cdd:COG4886 115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30425254 468 NLLQVLPAHIFLGIPLTRVNLKTNQFTHLPVSniLDDLDFLIQIDLEDN 516
Cdd:COG4886 192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
387-444 4.86e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 4.86e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30425254   387 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYN 444
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
410-470 2.00e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.00e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30425254   410 TRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLL 470
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-517 1.06e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 344 IHCQERNIESLSDLQPPPhNPRKLILAGNIIHTLmkSDLTDYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 423
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 424 KLnKGmFLGLHSLEYLYLEYNAVKEILPGTFNPM------PKLKVLYL-NNNL-----LQVLPAhiflgipLTRVNLKTN 491
Cdd:cd21340  82 VV-EG-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNIsGNNIdslepLAPLRN-------LEQLDASNN 152

                       170       180
                ....*....|....*....|....*..
gi 30425254 492 QFTHL-PVSNILDDLDFLIQIDLEDNP 517
Cdd:cd21340 153 QISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
92-146 2.40e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30425254    92 SIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-199 7.82e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 7.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  43 IMIINCEEKGINKLSQISVPPSRPFHLSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHinhn 122
Cdd:COG4886  24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT---- 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30425254 123 SLEILKEDTFHGLENLEFLQADNNFITIIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175
LRR_8 pfam13855
Leucine rich repeat;
114-172 2.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.77e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425254   114 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAI 172
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
137-195 3.98e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254   137 NLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 195
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
365-422 2.80e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.80e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 30425254   365 RKLILAGNIIHTLMKSDLTDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHL 422
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-615 7.38e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 7.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  95 LGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNfitiiepSAFSKLNRLKVLILNDNAIES 174
Cdd:COG4886  55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 175 LPPNIFRFVPLTHLDLRGNQLQTLPyvgflehigrildlqlednkwacncellqlknwlenmppqsiigdvicyspppfk 254
Cdd:COG4886 128 LPEELANLTNLKELDLSNNQLTDLP------------------------------------------------------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 255 gSVLSRLKkesfcptppvyeehedpsgsllaitsstsdsrlsskntsilkqptkapglipyltkpstqlpvpycpipcnc 334
Cdd:COG4886 153 -EPLGNLT------------------------------------------------------------------------ 159

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 335 kvlspsgllihcqerNIESLSdlqppphnprkliLAGNIIHTLmKSDLTDYFTLEMLHLGNNRIEVLEEgSFMNLTRLQK 414
Cdd:COG4886 160 ---------------NLKSLD-------------LSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEE 209

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 415 LYLNGNHLTKLNKGmFLGLHSLEYLYLEYNAVKEIlpGTFNPMPKLKVLYLNNNLLQVLPAHIFLGiPLTRVNLKTNQFT 494
Cdd:COG4886 210 LDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQLT 285

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 495 HLPVSNiLDDLDFLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCPGLVNNPSM 574
Cdd:COG4886 286 DLKLKE-LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                       490       500       510       520
                ....*....|....*....|....*....|....*....|.
gi 30425254 575 PTQTTYVIVTSPTVAADTASTLFSSLTDAVPLSVLILGLLI 615
Cdd:COG4886 365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-199 1.64e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 141
Cdd:cd21340  50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30425254 142 QADNNFITIIEPsaFSKLNRLKVLILNDNAIESLP---PNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 1.73e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLHtNDFSGLTNALSIHLGFNNIADIETgAFNGLGLLKQLHINHNSLEILKEdtFHGLENLEFLQADNNF 147
Cdd:COG4886 186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425254 148 ITIIEPSAfsKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 219
Cdd:COG4886 262 LTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
435-493 5.79e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254   435 SLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLQVLPAHIFLGIP-LTRVNLKTNQF 493
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-219 1.36e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  68 HLSLLNNGLTMLhtNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNF 147
Cdd:cd21340   6 HLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254 148 ITIIEpsAFSKLNRLKVLILNDNAIEslPPNIFRFVP---------LTHLDLRGNQLQTLPYVGFLEHIgRILDlqLEDN 218
Cdd:cd21340  80 ISVVE--GLENLTNLEELHIENQRLP--PGEKLTFDPrslaalsnsLRVLNISGNNIDSLEPLAPLRNL-EQLD--ASNN 152


                .
gi 30425254 219 K 219
Cdd:cd21340 153 Q 153
LRRCT smart00082
Leucine rich repeat C-terminal domain;
516-566 1.44e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 1.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 30425254    516 NPWDCSCDLVGLQQWIHKLGKGTMTDDILCTSPGHLDKKELKALNSDLLCP 566
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 98-193 1.74e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.84  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254    98 NNIADIETGAFNGLGLLKQLHINhNSLEILKEDTFHG--LENLEFlqadNNFITIIEPSAFSKLNRLKVLILNDNaIESL 175
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 30425254   176 PPNIFRFVPLTHLDLRGN 193
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
LRR_8 pfam13855
Leucine rich repeat;
69-124 2.53e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 30425254    69 LSLLNNGLTMLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSL 124
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-219 8.70e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254   161 RLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFlEHIGRILDLQLEDNK 219
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 1.50e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.41  E-value: 1.50e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425254    218 NKWACNCELLQLKNWLEN--MPPQSiiGDVICYSPPPFKGSVLSRLKKESFCP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 386-516 3.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  386 FTLEMLHLGNNRIE---VLEEGSFMNLTRLQklyLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKEILPGTFNPMPKLKV 462
Cdd:PLN00113 140 PNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30425254  463 LYLN-NNLLQVLPAHI---------------FLG-IPLTRVNLKTNQFTHL-------PVSNILDDLDFLIQIDLEDN 516
Cdd:PLN00113 217 IYLGyNNLSGEIPYEIggltslnhldlvynnLTGpIPSSLGNLKNLQYLFLyqnklsgPIPPSIFSLQKLISLDLSDN 294
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-179 3.75e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 3.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  54 NKLSQISVPPSRPFHLSLL---NNGLTMLhTNDFSGLTNALSIHLGFNNIADIEtgAFNGLGLLKQLHINHNSLEILKED 130
Cdd:COG4886 192 NQITDLPEPLGNLTNLEELdlsGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPL 268

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30425254 131 TfhGLENLEFLQADNNFITIIEPSAFSKLNRLKVLILNDNAIESLPPNI 179
Cdd:COG4886 269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR_8 pfam13855
Leucine rich repeat;
458-517 5.82e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30425254   458 PKLKVLYLNNNLLQVLPAHIFLGIP-LTRVNLKTNQFTHLPvSNILDDLDFLIQIDLEDNP 517
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 369-494 9.68e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425254  369 LAGNIIHTLmkSDLTDyftLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLNKGMFLGLHSLEYLYLEYNAVKE 448
Cdd:PLN00113 248 LTGPIPSSL--GNLKN---LQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG 322

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 30425254  449 ILPGTFNPMPKLKVLYL-NNNLLQVLPAHIFLGIPLTRVNLKTNQFT 494
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLwSNKFSGEIPKNLGKHNNLTVLDLSTNNLT 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH