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Conserved domains on  [gi|28376668|ref|NP_777586|]
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TLC domain-containing protein 5 isoform b [Homo sapiens]

Protein Classification

TLC domain-containing protein( domain architecture ID 1293)

TLC (TRAM, LAG1 and CLN8) domain-containing protein may possess multiple functions such as lipid trafficking, metabolism, or sensing

Gene Ontology:  GO:0016020
PubMed:  12151215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAM_LAG1_CLN8 super family cl02759
TLC domain;
51-117 7.01e-06

TLC domain;


The actual alignment was detected with superfamily member smart00724:

Pssm-ID: 470668  Cd Length: 205  Bit Score: 43.82  E-value: 7.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28376668     51 HRSYEWSCRLVTFTHGVLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHVLCLTLGYFIFDLGCIWRF 117
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLF 67
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
 51-117 7.01e-06

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 43.82  E-value: 7.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28376668     51 HRSYEWSCRLVTFTHGVLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHVLCLTLGYFIFDLGCIWRF 117
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLF 67
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
 51-117 7.01e-06

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 43.82  E-value: 7.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28376668     51 HRSYEWSCRLVTFTHGVLSIGLSAYIGFIDGPWPFTHPGSPNTPLQVHVLCLTLGYFIFDLGCIWRF 117
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLF 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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