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Conserved domains on  [gi|28372535|ref|NP_777570|]
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dynein light chain Tctex-type protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 85-196 1.62e-61

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


:

Pssm-ID: 412008  Cd Length: 112  Bit Score: 186.77  E-value: 1.62e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  85 NSYRMEPLKKFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIA 164
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRCRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 28372535 165 SRWIWDIAWDSWVAAKHEAESYVALVLVFALY 196
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
PRK13831 super family cl30572
conjugal transfer protein TrbI; Provisional
 11-72 7.61e-04

conjugal transfer protein TrbI; Provisional


The actual alignment was detected with superfamily member PRK13831:

Pssm-ID: 172358 [Multi-domain]  Cd Length: 432  Bit Score: 39.33  E-value: 7.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28372535   11 SPIQTPNQTPQQAPVTP----RKERRPSM---------FEKEAYTQILRERLRESIHNVQYVEPPFDDSIA-DIGK 72
Cdd:PRK13831  94 TPVETQQEEKAVNPFTPqpgqREERRPTLeseeewrarLKREQEEQYLRERQRQRMARLQANAAAYDSPLAvDIGK 169
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 85-196 1.62e-61

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 186.77  E-value: 1.62e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  85 NSYRMEPLKKFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIA 164
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRCRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 28372535 165 SRWIWDIAWDSWVAAKHEAESYVALVLVFALY 196
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 100-193 3.06e-27

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 99.14  E-value: 3.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535   100 VETKVQQILTESLK-DVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVA 178
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDHEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYAS 81

                          90
                  ....*....|....*
gi 28372535   179 AKHEAESYVALVLVF 193
Cdd:pfam03645  82 YKFENKSLFAVVTVF 96
PRK13831 PRK13831
conjugal transfer protein TrbI; Provisional
 11-72 7.61e-04

conjugal transfer protein TrbI; Provisional


Pssm-ID: 172358 [Multi-domain]  Cd Length: 432  Bit Score: 39.33  E-value: 7.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28372535   11 SPIQTPNQTPQQAPVTP----RKERRPSM---------FEKEAYTQILRERLRESIHNVQYVEPPFDDSIA-DIGK 72
Cdd:PRK13831  94 TPVETQQEEKAVNPFTPqpgqREERRPTLeseeewrarLKREQEEQYLRERQRQRMARLQANAAAYDSPLAvDIGK 169
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 85-196 1.62e-61

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 186.77  E-value: 1.62e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  85 NSYRMEPLKKFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIA 164
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRCRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 28372535 165 SRWIWDIAWDSWVAAKHEAESYVALVLVFALY 196
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 95-195 1.35e-29

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 105.27  E-value: 1.35e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  95 FQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWD 174
Cdd:cd21451   1 FNPEKVKKIIKEVLEERLENVTYDPEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 28372535 175 SWVAAKHEAESYVALVLVFAL 195
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 100-193 3.06e-27

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 99.14  E-value: 3.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535   100 VETKVQQILTESLK-DVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVA 178
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDHEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYAS 81

                          90
                  ....*....|....*
gi 28372535   179 AKHEAESYVALVLVF 193
Cdd:pfam03645  82 YKFENKSLFAVVTVF 96
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 94-197 8.00e-24

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 90.62  E-value: 8.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  94 KFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAW 173
Cdd:cd21459   1 KFRPSKVKEIIHEVLKEKLAGKTYDPEEAPQWTKEIADEIKDKLKELGFPRYKIVVQVVIGEQRGQGVRVGSRCLWDADT 80

                        90       100
                ....*....|....*....|....
gi 28372535 174 DSWVAAKHEAESYVALVLVFALYY 197
Cdd:cd21459  81 DNYASEVFINDSLFCVATVFGVYY 104
DLC-like_TCTEX1D4 cd21461
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) ...
 87-198 2.23e-19

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.


Pssm-ID: 412009  Cd Length: 114  Bit Score: 79.32  E-value: 2.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  87 YRMEPLK--KFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIA 164
Cdd:cd21461   1 YKTGPDPgcRFDASRVQQILEATLDSYLGGARYSPATCGQLSQGLSELVRSKVKDLSPPRYKLVCQVVLGQCGNQGLRVA 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 28372535 165 SRWIWDIAWDSWVAAKHEAESYVALVLVFALYYE 198
Cdd:cd21461  81 SRCLWDPERDNFASASFQNASLFAVATVHGVYFE 114
DLC-like_TCTEX1D1 cd21458
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) ...
 95-198 7.76e-13

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) and similar proteins; Tctex1 domain-containing protein 1 (TCTEX1D1) is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. The model corresponds to the (dynein light chain) DLC-like domain of TCTEX1D1.


Pssm-ID: 412006  Cd Length: 104  Bit Score: 61.92  E-value: 7.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535  95 FQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWD 174
Cdd:cd21458   1 FPVASVKNILKDVLESYLQEERYEPELCRQMTKTISEVIKARVKDLMLPRYKIIVLVHIGQLNDQGLRVGSRCLWDPAND 80

                        90       100
                ....*....|....*....|....
gi 28372535 175 SWVAAKHEAESYVALVLVFALYYE 198
Cdd:cd21458  81 TFSSYEFRNSSLFAVATVYGVYFE 104
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 104-194 8.89e-11

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 56.19  E-value: 8.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535 104 VQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHEA 183
Cdd:cd21449   6 IKEVLESILDDKEYDPLKLKEIAKKISEEIKEKLKELSPSRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVSEVYEN 85

                        90
                ....*....|.
gi 28372535 184 ESYVALVLVFA 194
Cdd:cd21449  86 DNIICTVTVFG 96
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 100-195 6.82e-10

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 53.73  E-value: 6.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535 100 VETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGyHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAA 179
Cdd:cd21455   3 VESIVKEAIEAVLGDKTYSHSKVNQWSNSIVEEILKRLAKLN-KPFKYIVTCVIMQKTGAGLHTASSCYWDPTTDGSVTV 81

                        90
                ....*....|....*.
gi 28372535 180 KHEAESYVALVLVFAL 195
Cdd:cd21455  82 RWENKTMYCIVTVFGL 97
DLC-like_DYNLT1-like cd21448
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 102-195 1.31e-05

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) subfamily and similar proteins; The dynein light chain Tctex-type 1 (DYNLT1) subfamily includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The family also includes Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1), Saccharomyces cerevisiae topoisomerase I damage affected protein 2 (TDA2) and similar proteins. SpDlc1 belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. TDA2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules.


Pssm-ID: 411996  Cd Length: 98  Bit Score: 42.43  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28372535 102 TKVQQILTESLKDVKyDDKVFSHLSLE-----LADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSW 176
Cdd:cd21448   1 RKLVTIIQEAIDSAL-DDNEYDHAKTEswsnlIIKLVLSELEKLSKSPFKYIANCTILSINNFGLHTATGAFWDSKKDGS 79

                        90
                ....*....|....*....
gi 28372535 177 VAAKHEAESYVALVLVFAL 195
Cdd:cd21448  80 FTYKWENKNMCQCITILWL 98
PRK13831 PRK13831
conjugal transfer protein TrbI; Provisional
 11-72 7.61e-04

conjugal transfer protein TrbI; Provisional


Pssm-ID: 172358 [Multi-domain]  Cd Length: 432  Bit Score: 39.33  E-value: 7.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28372535   11 SPIQTPNQTPQQAPVTP----RKERRPSM---------FEKEAYTQILRERLRESIHNVQYVEPPFDDSIA-DIGK 72
Cdd:PRK13831  94 TPVETQQEEKAVNPFTPqpgqREERRPTLeseeewrarLKREQEEQYLRERQRQRMARLQANAAAYDSPLAvDIGK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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