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Conserved domains on  [gi|110556629|ref|NP_775904|]
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transmembrane protein 145 isoform 2 precursor [Homo sapiens]

Protein Classification

seven transmembrane receptor family protein( domain architecture ID 10562848)

seven transmembrane receptor family protein similar to Homo sapiens intimal thickness related receptor (GPR180), which is not a GPCR (G protein-coupled receptor) but a component of the TGF-beta signaling pathway and regulates the activity of the TGF-beta receptor complex through SMAD3 phosphorylation, and transmembrane protein 145

Gene Ontology:  GO:0016020
PubMed:  34880217

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GpcrRhopsn4 pfam10192
Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven ...
 143-397 2.18e-75

Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.


:

Pssm-ID: 462989  Cd Length: 257  Bit Score: 237.53  E-value: 2.18e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  143 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 222
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  223 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAE-F 301
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYIKyF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  302 FDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLR--HFPEKQPFYVPFFAAYTLWFFAVPVMALIANFgIPKWARE 379
Cdd:pfam10192 161 FDPASKFHSYDSWPGYLLLALRIVLAIWFLYGLYNTYKkeKSPAKRQFYLKFGIVGTLWFLSFPVIVIIAHF-VDPYVRY 239

                         250
                  ....*....|....*...
gi 110556629  380 KIVNGIQLGIHLYAHGVF 397
Cdd:pfam10192 240 KVITIGTILIQFIAYIVL 257
 
Name Accession Description Interval E-value
GpcrRhopsn4 pfam10192
Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven ...
 143-397 2.18e-75

Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.


Pssm-ID: 462989  Cd Length: 257  Bit Score: 237.53  E-value: 2.18e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  143 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 222
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  223 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAE-F 301
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYIKyF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  302 FDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLR--HFPEKQPFYVPFFAAYTLWFFAVPVMALIANFgIPKWARE 379
Cdd:pfam10192 161 FDPASKFHSYDSWPGYLLLALRIVLAIWFLYGLYNTYKkeKSPAKRQFYLKFGIVGTLWFLSFPVIVIIAHF-VDPYVRY 239

                         250
                  ....*....|....*...
gi 110556629  380 KIVNGIQLGIHLYAHGVF 397
Cdd:pfam10192 240 KVITIGTILIQFIAYIVL 257
 
Name Accession Description Interval E-value
GpcrRhopsn4 pfam10192
Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven ...
 143-397 2.18e-75

Rhodopsin-like GPCR transmembrane domain; This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.


Pssm-ID: 462989  Cd Length: 257  Bit Score: 237.53  E-value: 2.18e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  143 GLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFF 222
Cdd:pfam10192   1 GLKLEYEITLTNGGDFLTSHFSADEQGILELFFFFFLLYIILLIINIVFIQALKKRGLKHPVLKLLSVILLLELISLLLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  223 CIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAE-F 301
Cdd:pfam10192  81 LIHLIVYSYNGIGIPLLQILGEILDILSQILFMLLLILLAKGWTITRYSLSSLNFVILLPIIILITVFQVILVIWYIKyF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556629  302 FDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLR--HFPEKQPFYVPFFAAYTLWFFAVPVMALIANFgIPKWARE 379
Cdd:pfam10192 161 FDPASKFHSYDSWPGYLLLALRIVLAIWFLYGLYNTYKkeKSPAKRQFYLKFGIVGTLWFLSFPVIVIIAHF-VDPYVRY 239

                         250
                  ....*....|....*...
gi 110556629  380 KIVNGIQLGIHLYAHGVF 397
Cdd:pfam10192 240 KVITIGTILIQFIAYIVL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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