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Conserved domains on  [gi|38348729|ref|NP_775821|]
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coiled-coil domain-containing protein 171 isoform 1 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
60-788 1.67e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     60 LASYESQIAKLRSEVEKGEALRQ------SLEYDLAVAR-KEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKElkaelrELELALLVLRlEELREELEELQEELKEAEEELEELTAELQELEEKLEELRL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    133 AFQtsqqKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEkhQREKNEMESHIRETALEEFRLQEEQ 212
Cdd:TIGR02168  275 EVS----ELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA--QLEELESKLDELAEELAELEEKLEE 348
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    213 WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA 292
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLK 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    293 AHLESKFnsEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSK 367
Cdd:TIGR02168  429 KLEEAEL--KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSE 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    368 NKKLNEDIEEQKKVIID-------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKEL 424
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGvlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEI 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    425 ESILDSFTVSGQWTSGIHKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASN------------------------EE 476
Cdd:TIGR02168  587 QGNDREILKNIEGFLGVAKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKlrpgyrivtldgdlvrpggvitggSA 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    477 KACNELDSTKQKIDSHTKNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAA 546
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLE 746
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    547 QSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEY 626
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRE 824
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    627 ICKNKSDTMRELQQTQEDTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQ 705
Cdd:TIGR02168  825 RLESLERRIAATERRLEDL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESE 874
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    706 LVlensHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEE 781
Cdd:TIGR02168  875 LE----ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYS 950

                   ....*..
gi 38348729    782 KKQEEAK 788
Cdd:TIGR02168  951 LTLEEAE 957
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
485-1246 4.00e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 4.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    485 TKQKIDSHTKNIKELQDKLADVNKELSHLHT--KCADR-----------------------EALISTLKVELQNVLHCWE 539
Cdd:TIGR02168  177 TERKLERTRENLDRLEDILNELERQLKSLERqaEKAERykelkaelrelelallvlrleelREELEELQEELKEAEEELE 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    540 KEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLvagcVLIKQPEGMLdkfswselcAVLQENVDALIADLNRANE 619
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA----NEISRLEQQK---------QILRERLANLERQLEELEA 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    620 KIRHLEyickNKSDTMRE---LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEI---AEKNM 693
Cdd:TIGR02168  324 QLEELE----SKLDELAEelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    694 EKLNHIEKSHEQLvleNSHFKKLLSQTQREQMSLLAAcalmagALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLA 773
Cdd:TIGR02168  400 NEIERLEARLERL---EDRRERLQQEIEELLKKLEEA------ELKELQAELEELEEELEELQEELERLEEALEELREEL 470
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    774 QALSTVEEKKQEEAKMKKKTFKGLIRIFR------KGVIAVLA-ANRLKILGQSCASLFTWMESFK--------EGIGML 838
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQEnlegfsEGVKALLKnQSGLSGILGVLSELISVDEGYEaaieaalgGRLQAV 550
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    839 VCTGEPQDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGAAKNSFAKLMDK 915
Cdd:TIGR02168  551 VVENLNAAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLGVAKDLVKFDPK 613
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    916 ISLVMEciPLHSSRSITyvekDSLVQ--RLAHGLHKVNTLALKYG--LRGHVPITKSTASLQKQILGFTQrlhaaevERR 991
Cdd:TIGR02168  614 LRKALS--YLLGGVLVV----DDLDNalELAKKLRPGYRIVTLDGdlVRPGGVITGGSAKTNSSILERRR-------EIE 680
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    992 SLRLEVTEFKRSVNEMKKELDKAQGLQMQL-NEFKQSKLITHE---KFESACEELNNALLREEQAQMLLNEQAQQLQELN 1067
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELeEELEQLRKELEElsrQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1068 YKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHM 1147
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL 840
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1148 RAVENTLHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGgpevvACQAMIKSFMDVYQLASTRIMTLEKEMTSH 1227
Cdd:TIGR02168  841 EDLEEQIEELSEDIES--LAAEIEELEELIEELESELEALLNERA-----SLEEALALLRSELEELSEELRELESKRSEL 913
                          810
                   ....*....|....*....
gi 38348729   1228 RSHIAALKSELHTACLREN 1246
Cdd:TIGR02168  914 RRELEELREKLAQLELRLE 932
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
60-788 1.67e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     60 LASYESQIAKLRSEVEKGEALRQ------SLEYDLAVAR-KEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKElkaelrELELALLVLRlEELREELEELQEELKEAEEELEELTAELQELEEKLEELRL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    133 AFQtsqqKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEkhQREKNEMESHIRETALEEFRLQEEQ 212
Cdd:TIGR02168  275 EVS----ELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA--QLEELESKLDELAEELAELEEKLEE 348
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    213 WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA 292
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLK 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    293 AHLESKFnsEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSK 367
Cdd:TIGR02168  429 KLEEAEL--KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSE 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    368 NKKLNEDIEEQKKVIID-------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKEL 424
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGvlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEI 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    425 ESILDSFTVSGQWTSGIHKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASN------------------------EE 476
Cdd:TIGR02168  587 QGNDREILKNIEGFLGVAKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKlrpgyrivtldgdlvrpggvitggSA 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    477 KACNELDSTKQKIDSHTKNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAA 546
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLE 746
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    547 QSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEY 626
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRE 824
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    627 ICKNKSDTMRELQQTQEDTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQ 705
Cdd:TIGR02168  825 RLESLERRIAATERRLEDL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESE 874
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    706 LVlensHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEE 781
Cdd:TIGR02168  875 LE----ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYS 950

                   ....*..
gi 38348729    782 KKQEEAK 788
Cdd:TIGR02168  951 LTLEEAE 957
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
64-378 1.17e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   64 ESQIAKLRSEVEKgeALR-QSLEYDLAvarkeaglgRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAfQTSQQKWK 142
Cdd:COG1196  199 ERQLEPLERQAEK--AERyRELKEELK---------ELEAELLLLKLRELEAELEELEAELEELEAELEEL-EAELAELE 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  143 EECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEmeshiretaLEEFRLQEEQWEAERRELQF 222
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER---------LEELEEELAELEEELEELEE 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  223 IVQEQDTAVQNMHKKVEKLETEhmdcsdLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAE-RAAHLESKfnS 301
Cdd:COG1196  338 ELEELEEELEEAEEELEEAEAE------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAaQLEELEEA--E 409
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729  302 EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQ 378
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
131-402 3.53e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 61.29  E-value: 3.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    131 EKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMEshiRETALEEFRLQE 210
Cdd:pfam17380  281 QKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAME---RERELERIRQEE 357
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    211 EqweaeRRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQ-TSELEFSTQREERLRK--EFEATTLRVRKLEENI 287
Cdd:pfam17380  358 R-----KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQElEAARKVKILEEERQRKiqQQKVEMEQIRAEQEEA 432
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    288 EAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEA---VADLEIIKNEFKEVESAYEREKHNAQESFA-KLNLLEKE 363
Cdd:pfam17380  433 RQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEerkRKKLELEKEKRDRKRAEEQRRKILEKELEErKQAMIEEE 512
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 38348729    364 yfSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 402
Cdd:pfam17380  513 --RKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEME 549
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
485-1246 4.00e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 4.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    485 TKQKIDSHTKNIKELQDKLADVNKELSHLHT--KCADR-----------------------EALISTLKVELQNVLHCWE 539
Cdd:TIGR02168  177 TERKLERTRENLDRLEDILNELERQLKSLERqaEKAERykelkaelrelelallvlrleelREELEELQEELKEAEEELE 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    540 KEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLvagcVLIKQPEGMLdkfswselcAVLQENVDALIADLNRANE 619
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA----NEISRLEQQK---------QILRERLANLERQLEELEA 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    620 KIRHLEyickNKSDTMRE---LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEI---AEKNM 693
Cdd:TIGR02168  324 QLEELE----SKLDELAEelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    694 EKLNHIEKSHEQLvleNSHFKKLLSQTQREQMSLLAAcalmagALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLA 773
Cdd:TIGR02168  400 NEIERLEARLERL---EDRRERLQQEIEELLKKLEEA------ELKELQAELEELEEELEELQEELERLEEALEELREEL 470
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    774 QALSTVEEKKQEEAKMKKKTFKGLIRIFR------KGVIAVLA-ANRLKILGQSCASLFTWMESFK--------EGIGML 838
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQEnlegfsEGVKALLKnQSGLSGILGVLSELISVDEGYEaaieaalgGRLQAV 550
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    839 VCTGEPQDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGAAKNSFAKLMDK 915
Cdd:TIGR02168  551 VVENLNAAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLGVAKDLVKFDPK 613
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    916 ISLVMEciPLHSSRSITyvekDSLVQ--RLAHGLHKVNTLALKYG--LRGHVPITKSTASLQKQILGFTQrlhaaevERR 991
Cdd:TIGR02168  614 LRKALS--YLLGGVLVV----DDLDNalELAKKLRPGYRIVTLDGdlVRPGGVITGGSAKTNSSILERRR-------EIE 680
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    992 SLRLEVTEFKRSVNEMKKELDKAQGLQMQL-NEFKQSKLITHE---KFESACEELNNALLREEQAQMLLNEQAQQLQELN 1067
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELeEELEQLRKELEElsrQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1068 YKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHM 1147
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL 840
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1148 RAVENTLHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGgpevvACQAMIKSFMDVYQLASTRIMTLEKEMTSH 1227
Cdd:TIGR02168  841 EDLEEQIEELSEDIES--LAAEIEELEELIEELESELEALLNERA-----SLEEALALLRSELEELSEELRELESKRSEL 913
                          810
                   ....*....|....*....
gi 38348729   1228 RSHIAALKSELHTACLREN 1246
Cdd:TIGR02168  914 RRELEELREKLAQLELRLE 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
29-567 1.20e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.23  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    29 ETELDITDNLRKKLHWAKKEKLEITTKHN---AELASYESQIAKLRSEVEKGEALRQSLEyDLAVARKEAGLGRRAAEER 105
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINeisSELPELREELEKLEKEVKELEELKEEIE-ELEKELESLEGSKRKLEEK 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   106 LAEAHRIQEKLCAQNSELQAKTNETEK---------AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRL 176
Cdd:PRK03918  261 IRELEERIEELKKEIEELEEKVKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERL 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   177 EKtLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERRELQFIVQEQdtaVQNMHKKVEKLETEHMDCSDLLRRQT 256
Cdd:PRK03918  341 EE-LKKKLKELEKRLEELEE--RHELYEEAKAKKEELERLKKRLTGLTPEK---LEKELEELEKAKEEIEEEISKITARI 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   257 SELEfstQREERLRKEFEA-------TTLRVRKLEENIEAE--RAAHLE-SKFNSEIIQL--RIRDLEGAL-QVEKA-SQ 322
Cdd:PRK03918  415 GELK---KEIKELKKAIEElkkakgkCPVCGRELTEEHRKEllEEYTAElKRIEKELKEIeeKERKLRKELrELEKVlKK 491
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   323 AEAVADLEIIKNEFKEVESayEREKHNAQESFAKLNLLE--KEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ 400
Cdd:PRK03918  492 ESELIKLKELAEQLKELEE--KLKKYNLEELEKKAEEYEklKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELE 569
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   401 EELVMAKKHQAFL----VETCENNVKELESILDSFTVSGQWTSGIHKDKDKppsfsvvLERLRRTLTDYQNKLEDASNE- 475
Cdd:PRK03918  570 EELAELLKELEELgfesVEELEERLKELEPFYNEYLELKDAEKELEREEKE-------LKKLEEELDKAFEELAETEKRl 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   476 EKACNELDSTKQKIDShtKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHcwEKEKAQAAQSESELQKL 555
Cdd:PRK03918  643 EELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE--ELEEREKAKKELEKLEK 718
                         570
                  ....*....|..
gi 38348729   556 SQAFHKDAEEKL 567
Cdd:PRK03918  719 ALERVEELREKV 730
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
970-1141 2.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  970 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlqmQLNEFKQSKLITHEKFESACEELNNALLRE 1049
Cdd:COG1196  242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERL 318
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1050 EQAQM----LLNEQA---QQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRL 1122
Cdd:COG1196  319 EELEEelaeLEEELEeleEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                        170
                 ....*....|....*....
gi 38348729 1123 EENIHDAESALRMAAKDKE 1141
Cdd:COG1196  399 AAQLEELEEAEEALLERLE 417
PRK11281 PRK11281
mechanosensitive channel MscK;
967-1133 2.30e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   967 KSTASLQKQILGFTQRLhaaeverRSLRLEVTEFKRSVNEMKKE----LDKAQgLQMQLNEfkqskliTHEKFESACEEL 1042
Cdd:PRK11281   80 EETEQLKQQLAQAPAKL-------RQAQAELEALKDDNDEETREtlstLSLRQ-LESRLAQ-------TLDQLQNAQNDL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  1043 N--NALL-----REEQAQMLLNEQAQQLQELNykLELHSSEEADKN-----QTLGEAVKSLSEAKMELRRKD-------Q 1103
Cdd:PRK11281  145 AeyNSQLvslqtQPERAQAALYANSQRLQQIR--NLLKGGKVGGKAlrpsqRVLLQAEQALLNAQNDLQRKSlegntqlQ 222
                         170       180       190
                  ....*....|....*....|....*....|
gi 38348729  1104 SLRQLNRHLTQLEQDkrRLEENIHDAESAL 1133
Cdd:PRK11281  223 DLLQKQRDYLTARIQ--RLEHQLQLLQEAI 250
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
60-788 1.67e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     60 LASYESQIAKLRSEVEKGEALRQ------SLEYDLAVAR-KEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEK 132
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKElkaelrELELALLVLRlEELREELEELQEELKEAEEELEELTAELQELEEKLEELRL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    133 AFQtsqqKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEkhQREKNEMESHIRETALEEFRLQEEQ 212
Cdd:TIGR02168  275 EVS----ELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA--QLEELESKLDELAEELAELEEKLEE 348
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    213 WEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERA 292
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLK 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    293 AHLESKFnsEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLE-----KEYFSK 367
Cdd:TIGR02168  429 KLEEAEL--KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLErlqenLEGFSE 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    368 NKKLNEDIEEQKKVIID-------------------LSKRLQY----NEKSCSELQEELVMAKKHQAFLVETCENNVKEL 424
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGvlselisvdegyeaaieaaLGGRLQAvvveNLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEI 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    425 ESILDSFTVSGQWTSGIHKDKDK-PPSFSVVLE-RLRRTL--TDYQNKLEDASN------------------------EE 476
Cdd:TIGR02168  587 QGNDREILKNIEGFLGVAKDLVKfDPKLRKALSyLLGGVLvvDDLDNALELAKKlrpgyrivtldgdlvrpggvitggSA 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    477 KACNELDSTKQKIDSHTKNIK-------ELQDKLADVNKELSHLHTKCADREAL---ISTLKVELQNVLHCWEKEKAQAA 546
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEeleekiaELEKALAELRKELEELEEELEQLRKEleeLSRQISALRKDLARLEAEVEQLE 746
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    547 QSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFswSELCAVLQENVDALIADLNRANEKIRHLEY 626
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL--KEELKALREALDELRAELTLLNEEAANLRE 824
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    627 ICKNKSDTMRELQQTQEDTftkvaeqikaqescwHRQKKELELQyselflevqkraqkfQEIAEKNMEKLN-HIEKSHEQ 705
Cdd:TIGR02168  825 RLESLERRIAATERRLEDL---------------EEQIEELSED---------------IESLAAEIEELEeLIEELESE 874
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    706 LVlensHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFEL----FKLEIRTLAQALSTVEE 781
Cdd:TIGR02168  875 LE----ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELrlegLEVRIDNLQERLSEEYS 950

                   ....*..
gi 38348729    782 KKQEEAK 788
Cdd:TIGR02168  951 LTLEEAE 957
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
64-378 1.17e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   64 ESQIAKLRSEVEKgeALR-QSLEYDLAvarkeaglgRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAfQTSQQKWK 142
Cdd:COG1196  199 ERQLEPLERQAEK--AERyRELKEELK---------ELEAELLLLKLRELEAELEELEAELEELEAELEEL-EAELAELE 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  143 EECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEmeshiretaLEEFRLQEEQWEAERRELQF 222
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER---------LEELEEELAELEEELEELEE 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  223 IVQEQDTAVQNMHKKVEKLETEhmdcsdLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAE-RAAHLESKfnS 301
Cdd:COG1196  338 ELEELEEELEEAEEELEEAEAE------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAaQLEELEEA--E 409
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729  302 EIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQ 378
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
68-377 9.81e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 63.55  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     68 AKLRSEVEKGEALRQSLEYDLAVARKEaglgRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEecrr 147
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSE----LRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE---- 741
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    148 FEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL---QEALEkhqreknEMESHIRETALEEFRLQEEQWEAERRELQFIV 224
Cdd:TIGR02169  742 LEEDLSSLEQEIENVKSELKELEARIEELEEDLhklEEALN-------DLEARLSHSRIPEIQAELSKLEEEVSRIEARL 814
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    225 QEQDTAVQNMHKKVEKLETEHMDcsdlLRRQTSELEfstQREERLRKEFEATTLRVRKLEENIEAeraahleskfnseiI 304
Cdd:TIGR02169  815 REIEQKLNRLTLEKEYLEKEIQE----LQEQRIDLK---EQIKSIEKEIENLNGKKEELEEELEE--------------L 873
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38348729    305 QLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEE 377
Cdd:TIGR02169  874 EAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
164-430 2.65e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.88  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  164 REYDLLMKEKSRLEKTL-----QEALEKHQREKNEMESHirETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKV 238
Cdd:COG1196  213 ERYRELKEELKELEAELlllklRELEAELEELEAELEEL--EAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  239 EKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVE 318
Cdd:COG1196  291 YELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  319 KASQAEAVADLEIIKNEFKEVESA---YEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS 395
Cdd:COG1196  371 EAELAEAEEELEELAEELLEALRAaaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 38348729  396 CSELQEELVMAKKHQAFLVETCENNVKELESILDS 430
Cdd:COG1196  451 EAELEEEEEALLELLAELLEEAALLEAALAELLEE 485
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
131-402 3.53e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 61.29  E-value: 3.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    131 EKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMEshiRETALEEFRLQE 210
Cdd:pfam17380  281 QKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAME---RERELERIRQEE 357
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    211 EqweaeRRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQ-TSELEFSTQREERLRK--EFEATTLRVRKLEENI 287
Cdd:pfam17380  358 R-----KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQElEAARKVKILEEERQRKiqQQKVEMEQIRAEQEEA 432
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    288 EAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEA---VADLEIIKNEFKEVESAYEREKHNAQESFA-KLNLLEKE 363
Cdd:pfam17380  433 RQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEerkRKKLELEKEKRDRKRAEEQRRKILEKELEErKQAMIEEE 512
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 38348729    364 yfSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 402
Cdd:pfam17380  513 --RKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEME 549
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
62-377 6.23e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 6.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     62 SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNEtekafqtsQQKW 141
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAE--------VEQL 745
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    142 KEECRRFEHDLEERDNMIqncnreydllMKEKSRLEKtLQEALEKHQREKNEMESHIretalEEFRLQEEQWEAERRELQ 221
Cdd:TIGR02168  746 EERIAQLSKELTELEAEI----------EELEERLEE-AEEELAEAEAEIEELEAQI-----EQLKEELKALREALDELR 809
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    222 FIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA---------ERA 292
Cdd:TIGR02168  810 AELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAllnerasleEAL 889
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    293 AHLESKFNSEIIQLR-----IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESA----YEREKHNAQESFAKLNLLEKE 363
Cdd:TIGR02168  890 ALLRSELEELSEELReleskRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlseeYSLTLEEAEALENKIEDDEEE 969
                          330
                   ....*....|....
gi 38348729    364 YFSKNKKLNEDIEE 377
Cdd:TIGR02168  970 ARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
91-431 6.49e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 6.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     91 ARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQkwkeecrrfehDLEERDNMIQNCNREYDLLM 170
Cdd:TIGR02168  664 GSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEE-----------ELEQLRKELEELSRQISALR 732
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    171 KEKSRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQW-----EAERRELQFIVQEQDTAVQNMHKKVEKLETEH 245
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEelaeaEAEIEELEAQIEQLKEELKALREALDELRAEL 812
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    246 MDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAeraahleskfnseiiqlrirdLEGALQVEKASQAEA 325
Cdd:TIGR02168  813 TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES---------------------LAAEIEELEELIEEL 871
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    326 VADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSK---RLQYNEKSCSELQE- 401
Cdd:TIGR02168  872 ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGlevRIDNLQERLSEEYSl 951
                          330       340       350
                   ....*....|....*....|....*....|...
gi 38348729    402 ELVMAKKHQAFLV---ETCENNVKELESILDSF 431
Cdd:TIGR02168  952 TLEEAEALENKIEddeEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
485-1246 4.00e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 4.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    485 TKQKIDSHTKNIKELQDKLADVNKELSHLHT--KCADR-----------------------EALISTLKVELQNVLHCWE 539
Cdd:TIGR02168  177 TERKLERTRENLDRLEDILNELERQLKSLERqaEKAERykelkaelrelelallvlrleelREELEELQEELKEAEEELE 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    540 KEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLvagcVLIKQPEGMLdkfswselcAVLQENVDALIADLNRANE 619
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA----NEISRLEQQK---------QILRERLANLERQLEELEA 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    620 KIRHLEyickNKSDTMRE---LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEI---AEKNM 693
Cdd:TIGR02168  324 QLEELE----SKLDELAEelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    694 EKLNHIEKSHEQLvleNSHFKKLLSQTQREQMSLLAAcalmagALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLA 773
Cdd:TIGR02168  400 NEIERLEARLERL---EDRRERLQQEIEELLKKLEEA------ELKELQAELEELEEELEELQEELERLEEALEELREEL 470
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    774 QALSTVEEKKQEEAKMKKKTFKGLIRIFR------KGVIAVLA-ANRLKILGQSCASLFTWMESFK--------EGIGML 838
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQEnlegfsEGVKALLKnQSGLSGILGVLSELISVDEGYEaaieaalgGRLQAV 550
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    839 VCTGEPQDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGAAKNSFAKLMDK 915
Cdd:TIGR02168  551 VVENLNAAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLGVAKDLVKFDPK 613
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    916 ISLVMEciPLHSSRSITyvekDSLVQ--RLAHGLHKVNTLALKYG--LRGHVPITKSTASLQKQILGFTQrlhaaevERR 991
Cdd:TIGR02168  614 LRKALS--YLLGGVLVV----DDLDNalELAKKLRPGYRIVTLDGdlVRPGGVITGGSAKTNSSILERRR-------EIE 680
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    992 SLRLEVTEFKRSVNEMKKELDKAQGLQMQL-NEFKQSKLITHE---KFESACEELNNALLREEQAQMLLNEQAQQLQELN 1067
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELeEELEQLRKELEElsrQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1068 YKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHM 1147
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL 840
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1148 RAVENTLHKVRDQISLswSAASRNDFTLQLPKLHLETFAMEGLKGgpevvACQAMIKSFMDVYQLASTRIMTLEKEMTSH 1227
Cdd:TIGR02168  841 EDLEEQIEELSEDIES--LAAEIEELEELIEELESELEALLNERA-----SLEEALALLRSELEELSEELRELESKRSEL 913
                          810
                   ....*....|....*....
gi 38348729   1228 RSHIAALKSELHTACLREN 1246
Cdd:TIGR02168  914 RRELEELREKLAQLELRLE 932
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
261-558 5.38e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 5.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    261 FSTQRE-ERLRKEFEATTLRVRKLEENIEAERAAHLEskfnseiIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEV 339
Cdd:TIGR02168  673 LERRREiEELEEKIEELEEKIAELEKALAELRKELEE-------LEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    340 ESAYEREKHNAQESFAKLNLLEK---EYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVET 416
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEErleEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRER 825
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    417 CENNVKELESILDSFTVSGQWTSGIHKDKDkppSFSVVLERLRRTLTDYQNKLEDASNE--------EKACNELDSTKQK 488
Cdd:TIGR02168  826 LESLERRIAATERRLEDLEEQIEELSEDIE---SLAAEIEELEELIEELESELEALLNErasleealALLRSELEELSEE 902
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 38348729    489 IDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLK--------VELQNVLHCWEKEKAQAAQSESELQKLSQA 558
Cdd:TIGR02168  903 LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQerlseeysLTLEEAEALENKIEDDEEEARRRLKRLENK 980
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
134-475 5.89e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.39  E-value: 5.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    134 FQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKtlqeaLEKHQREKNEMESHIRETALEEFRLQEEQW 213
Cdd:TIGR02169  168 FDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAER-----YQALLKEKREYEGYELLKEKEALERQKEAI 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    214 EAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSElefstqREERLRKEFEATTLRVRKLEENI-----E 288
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEE------EQLRVKEKIGELEAEIASLERSIaekerE 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    289 AERAAHLESKFNSEI--IQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLnlleKEYFS 366
Cdd:TIGR02169  317 LEDAEERLAKLEAEIdkLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDEL----KDYRE 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    367 KNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESIldsftvsGQWTSGIHKDKD 446
Cdd:TIGR02169  393 KLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ-------EWKLEQLAADLS 465
                          330       340
                   ....*....|....*....|....*....
gi 38348729    447 KppsFSVVLERLRRTLTDYQNKLEDASNE 475
Cdd:TIGR02169  466 K---YEQELYDLKEEYDRVEKELSKLQRE 491
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
29-567 1.20e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.23  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    29 ETELDITDNLRKKLHWAKKEKLEITTKHN---AELASYESQIAKLRSEVEKGEALRQSLEyDLAVARKEAGLGRRAAEER 105
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINeisSELPELREELEKLEKEVKELEELKEEIE-ELEKELESLEGSKRKLEEK 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   106 LAEAHRIQEKLCAQNSELQAKTNETEK---------AFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRL 176
Cdd:PRK03918  261 IRELEERIEELKKEIEELEEKVKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERL 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   177 EKtLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERRELQFIVQEQdtaVQNMHKKVEKLETEHMDCSDLLRRQT 256
Cdd:PRK03918  341 EE-LKKKLKELEKRLEELEE--RHELYEEAKAKKEELERLKKRLTGLTPEK---LEKELEELEKAKEEIEEEISKITARI 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   257 SELEfstQREERLRKEFEA-------TTLRVRKLEENIEAE--RAAHLE-SKFNSEIIQL--RIRDLEGAL-QVEKA-SQ 322
Cdd:PRK03918  415 GELK---KEIKELKKAIEElkkakgkCPVCGRELTEEHRKEllEEYTAElKRIEKELKEIeeKERKLRKELrELEKVlKK 491
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   323 AEAVADLEIIKNEFKEVESayEREKHNAQESFAKLNLLE--KEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQ 400
Cdd:PRK03918  492 ESELIKLKELAEQLKELEE--KLKKYNLEELEKKAEEYEklKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELE 569
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   401 EELVMAKKHQAFL----VETCENNVKELESILDSFTVSGQWTSGIHKDKDKppsfsvvLERLRRTLTDYQNKLEDASNE- 475
Cdd:PRK03918  570 EELAELLKELEELgfesVEELEERLKELEPFYNEYLELKDAEKELEREEKE-------LKKLEEELDKAFEELAETEKRl 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   476 EKACNELDSTKQKIDShtKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHcwEKEKAQAAQSESELQKL 555
Cdd:PRK03918  643 EELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE--ELEEREKAKKELEKLEK 718
                         570
                  ....*....|..
gi 38348729   556 SQAFHKDAEEKL 567
Cdd:PRK03918  719 ALERVEELREKV 730
PTZ00121 PTZ00121
MAEBL; Provisional
22-503 7.31e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 7.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    22 VKQILKNETELDITDNLRKKLHWAKKEkleittkhnAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRA 101
Cdd:PTZ00121 1304 ADEAKKKAEEAKKADEAKKKAEEAKKK---------ADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKE 1374
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   102 AEERLAEAHRIQEKLCAQNSELQAKTNETEKafQTSQQKWKEECRRFEHDLEERDNMIQNCNrEYDLLMKEKSRLEKTLQ 181
Cdd:PTZ00121 1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKK--KADELKKAAAAKKKADEAKKKAEEKKKAD-EAKKKAEEAKKADEAKK 1451
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   182 EALEKHQREKNEMESHIRETALEEFRLQEEQWEAErrELQFIVQEQDTAVQNMHKKVE-KLETEHMDCSDLLRR--QTSE 258
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD--EAKKKAEEAKKKADEAKKAAEaKKKADEAKKAEEAKKadEAKK 1529
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   259 LEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQ-LRIRDLEGALQVEKASQAEAVADLEIIKNEFK 337
Cdd:PTZ00121 1530 AEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   338 EVESAYEREKHNAQE---------SFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 408
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEElkkaeeekkKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   409 HQAFLVETCENNvKELESILDSFTVSGQWTSGIHKDKDKPpsfSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQK 488
Cdd:PTZ00121 1690 AAEALKKEAEEA-KKAEELKKKEAEEKKKAEELKKAEEEN---KIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765
                         490
                  ....*....|....*
gi 38348729   489 IDSHTKNIKELQDKL 503
Cdd:PTZ00121 1766 EEKKAEEIRKEKEAV 1780
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
173-513 3.47e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.43  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    173 KSRLEKTLQEALEKHQreKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLl 252
Cdd:pfam07888   33 QNRLEECLQERAELLQ--AQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSAS- 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    253 rrqtseLEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEII 332
Cdd:pfam07888  110 ------SEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQT 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    333 KNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNE------DIEEQKKVIIDLSKRLQYNEKSCSELQEEL--- 403
Cdd:pfam07888  184 EEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTahrkeaENEALLEELRSLQERLNASERKVEGLGEELssm 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    404 ------VMAKKHQAFLvETCENNVKELESILDSFTVSGQWTS-------GIHKDKDKPPSFSVVLERLRRTLTdyqnklE 470
Cdd:pfam07888  264 aaqrdrTQAELHQARL-QAAQLTLQLADASLALREGRARWAQeretlqqSAEADKDRIEKLSAELQRLEERLQ------E 336
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 38348729    471 DASNEEKACNEL----DSTKQKIDSHTKNIKELQDKLADVNKELSHL 513
Cdd:pfam07888  337 ERMEREKLEVELgrekDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
54-291 3.95e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.48  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   54 TKHNAELASYESQIAKLRSEVEKGEALRQSLE---YDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
Cdd:COG1196  284 EEAQAEEYELLAELARLEQDIARLEERRRELEerlEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  131 EKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLmKEKSRLEKTLQEALEKHQREKNEMESHIRETALEefRLQE 210
Cdd:COG1196  364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL-EELEEAEEALLERLERLEEELEELEEALAELEEE--EEEE 440
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  211 EQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAE 290
Cdd:COG1196  441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520

                 .
gi 38348729  291 R 291
Cdd:COG1196  521 G 521
PTZ00121 PTZ00121
MAEBL; Provisional
36-566 4.19e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    36 DNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEK 115
Cdd:PTZ00121 1233 EEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAE 1312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   116 LCAQNSELQAKTNETEKAFQTSQQKWKE-----ECRRFEHDLEERDNMIQNCNREYDLLMKEKSRL----------EKTL 180
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEakkaaEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKkadaakkkaeEKKK 1392
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   181 QEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERR----ELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQT 256
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKkkadEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKA 1472
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   257 SELEFSTQ---REERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIK 333
Cdd:PTZ00121 1473 DEAKKKAEeakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELK 1552
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   334 N--------EFKEVESAyEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVM 405
Cdd:PTZ00121 1553 KaeelkkaeEKKKAEEA-KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE 1631
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   406 AKKHQAfLVETCENNVKELESIldsftvsgqwtsgihkdKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDST 485
Cdd:PTZ00121 1632 KKKVEQ-LKKKEAEEKKKAEEL-----------------KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   486 KQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNvlhcwEKEKAQAAQSESELQKLSQAFHKDAEE 565
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEE-----DKKKAEEAKKDEEEKKKIAHLKKEEEK 1768

                  .
gi 38348729   566 K 566
Cdd:PTZ00121 1769 K 1769
PTZ00121 PTZ00121
MAEBL; Provisional
23-509 6.07e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    23 KQILKNETELDITDNLRKKLHWAKK----EKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLG 98
Cdd:PTZ00121 1460 EEAKKKAEEAKKADEAKKKAEEAKKadeaKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    99 RRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEK 178
Cdd:PTZ00121 1540 KKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   179 TLQEALEKHQREKNEMESHIRETAlEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVE--KLETEHMDCSDLLRRQT 256
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEA-EEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEakKAEEDEKKAAEALKKEA 1698
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   257 SElefsTQREERLRKEFEAttlRVRKLEENIEAEraahleskfnsEIIQLRIRDLEGALQVEKASQAEAVADlEIIKNEF 336
Cdd:PTZ00121 1699 EE----AKKAEELKKKEAE---EKKKAEELKKAE-----------EENKIKAEEAKKEAEEDKKKAEEAKKD-EEEKKKI 1759
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   337 KEVESayEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKS----CSELQEELVMAKKHQAF 412
Cdd:PTZ00121 1760 AHLKK--EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEgnlvINDSKEMEDSAIKEVAD 1837
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   413 LVETCENNVKELESILDSF----TVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE-DASNEEKACNELDSTKQ 487
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKnnenGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIErEIPNNNMAGKNNDIIDD 1917
                         490       500
                  ....*....|....*....|....*
gi 38348729   488 KIDSH---TKNIKELQDKLADVNKE 509
Cdd:PTZ00121 1918 KLDKDeyiKRDAEETREEIIKISKK 1942
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
88-516 6.79e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.83  E-value: 6.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    88 LAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKE--ECRRFEHDLEERDNMIQNCNRE 165
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEleKLEKEVKELEELKEEIEELEKE 246
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   166 YDLLMKEKSRLEKTLQEaLEKHQREKnemESHIRETALEEFRLQEEQWEAER-RELQFIVQEQDTAVQNMHKKVEKLETE 244
Cdd:PRK03918  247 LESLEGSKRKLEEKIRE-LEERIEEL---KKEIEELEEKVKELKELKEKAEEyIKLSEFYEEYLDELREIEKRLSRLEEE 322
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   245 hmdcSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA-ERAAHLESKFNseiiqlRIRDLEGALQVEKasqa 323
Cdd:PRK03918  323 ----INGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELyEEAKAKKEELE------RLKKRLTGLTPEK---- 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   324 eavadleiIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNE----------------------DIEEQKKV 381
Cdd:PRK03918  389 --------LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEElkkakgkcpvcgrelteehrkeLLEEYTAE 460
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   382 IIDLSKRLQYNEKSCSELQEELV-----MAKKHQAFLVETCENNVKELESILDSFTvsgqwtsgihkdkdkppsfsvvLE 456
Cdd:PRK03918  461 LKRIEKELKEIEEKERKLRKELRelekvLKKESELIKLKELAEQLKELEEKLKKYN----------------------LE 518
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   457 RLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTK 516
Cdd:PRK03918  519 ELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKE 578
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
171-790 7.58e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   171 KEKSRLEKTLQEALEKHQREKNEMESHIREtaLEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEhmdcsd 250
Cdd:PRK03918  210 NEISSELPELREELEKLEKEVKELEELKEE--IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEK------ 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   251 llRRQTSELEFSTQREERLRKEFEATTLRVRKLEEnieaeRAAHLESKFNSeiIQLRIRDLEgalqvekasqaEAVADLE 330
Cdd:PRK03918  282 --VKELKELKEKAEEYIKLSEFYEEYLDELREIEK-----RLSRLEEEING--IEERIKELE-----------EKEERLE 341
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   331 IIKNEFKEVESAYEREKHNA---QESFAKLNLLEKeyfSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAK 407
Cdd:PRK03918  342 ELKKKLKELEKRLEELEERHelyEEAKAKKEELER---LKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELK 418
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   408 KHQAFLvetcENNVKELEsildsftvsgqwtsgihKDKDKPPSfsvvlerLRRTLTdyqnkledasnEEKACNELDSTKQ 487
Cdd:PRK03918  419 KEIKEL----KKAIEELK-----------------KAKGKCPV-------CGRELT-----------EEHRKELLEEYTA 459
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   488 KIDSHTKNIKELQDKLADVNKELSHLHTKCADREALIstlkvelqnvlhcweKEKAQAAQSESELQKLSQAFHKDAEEKL 567
Cdd:PRK03918  460 ELKRIEKELKEIEEKERKLRKELRELEKVLKKESELI---------------KLKELAEQLKELEEKLKKYNLEELEKKA 524
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   568 TFLHTLYQHLVAgcvLIKQPEGMLDKFswselcavlqENVDALIADLNRANEKIRHLEyicKNKSDTMRELQQTQEDTFT 647
Cdd:PRK03918  525 EEYEKLKEKLIK---LKGEIKSLKKEL----------EKLEELKKKLAELEKKLDELE---EELAELLKELEELGFESVE 588
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   648 KVAEQIKAQESCWhrqKKELELQYSELFLEV-QKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQ----- 721
Cdd:PRK03918  589 ELEERLKELEPFY---NEYLELKDAEKELEReEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEyeelr 665
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38348729   722 REQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMK 790
Cdd:PRK03918  666 EEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYK 734
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
100-622 7.82e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 7.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  100 RAAEERLAEAHRIQEKLCAQNSELQAKTNETEKA-FQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKS---- 174
Cdd:COG4913  258 RELAERYAAARERLAELEYLRAALRLWFAQRRLElLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRgngg 337
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  175 RLEKTLQEALEKHQREKNEMEsHIRETALEEFRLQEEQWEAERRELQfivqeqdTAVQNMHKKVEKLETEHMDCSDLLRR 254
Cdd:COG4913  338 DRLEQLEREIERLERELEERE-RRRARLEALLAALGLPLPASAEEFA-------ALRAEAAALLEALEEELEALEEALAE 409
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  255 QTSELEFSTQREERLRKEFEAttLRVRKLeeNIEAeraahleskfnsEIIQLRiRDLEGALQVeKASQAEAVADLEIIKN 334
Cdd:COG4913  410 AEAALRDLRRELRELEAEIAS--LERRKS--NIPA------------RLLALR-DALAEALGL-DEAELPFVGELIEVRP 471
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  335 EFKEVESAYEREKHNaqesfAKLNLL-EKEYFSK-------NK--------KLNEDIEEQKKVIID---LSKRLQYNEKS 395
Cdd:COG4913  472 EEERWRGAIERVLGG-----FALTLLvPPEHYAAalrwvnrLHlrgrlvyeRVRTGLPDPERPRLDpdsLAGKLDFKPHP 546
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  396 CSE-LQEELvmakkHQAFLVETCEnNVKELESILDSFTVSGQ----WTSGIHKDKDKPPSFSVV--------------LE 456
Cdd:COG4913  547 FRAwLEAEL-----GRRFDYVCVD-SPEELRRHPRAITRAGQvkgnGTRHEKDDRRRIRSRYVLgfdnraklaaleaeLA 620
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  457 RLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHT---KNIKELQDKLADVNKELSHLHTKCADREAL---ISTLKVE 530
Cdd:COG4913  621 ELEEELAEAEERLEALEAELDALQERREALQRLAEYSwdeIDVASAEREIAELEAELERLDASSDDLAALeeqLEELEAE 700
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  531 LQNVlhcwEKEKAQAAQSESELQKLsqafHKDAEEKLTFLHTLYQHLVAGCV------LIKQPEGMLDKFSWSELCAVLQ 604
Cdd:COG4913  701 LEEL----EEELDELKGEIGRLEKE----LEQAEEELDELQDRLEAAEDLARlelralLEERFAAALGDAVERELRENLE 772
                        570
                 ....*....|....*...
gi 38348729  605 ENVDALIADLNRANEKIR 622
Cdd:COG4913  773 ERIDALRARLNRAEEELE 790
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
295-545 7.90e-06

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 50.31  E-value: 7.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   295 LESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAyerekhnAQESFAKLNLLEKEYFSKNKKLNEd 374
Cdd:PRK05771   40 LSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEEL-------IKDVEEELEKIEKEIKELEEEISE- 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   375 IEEQKKVIIDLSKRLQYNEKSCSELQEELvmAKKH-QAFLVETCENNVKELESILDSFTVsgqwtSGIHKDKDKPPSFSV 453
Cdd:PRK05771  112 LENEIKELEQEIERLEPWGNFDLDLSLLL--GFKYvSVFVGTVPEDKLEELKLESDVENV-----EYISTDKGYVYVVVV 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   454 VLERLrrtLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADreaLISTLKVELQN 533
Cdd:PRK05771  185 VLKEL---SDEVEEELKKLGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLE---ELLALYEYLEI 258
                         250
                  ....*....|..
gi 38348729   534 vlhcwEKEKAQA 545
Cdd:PRK05771  259 -----ELERAEA 265
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
970-1141 2.06e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  970 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGlqmQLNEFKQSKLITHEKFESACEELNNALLRE 1049
Cdd:COG1196  242 EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERL 318
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1050 EQAQM----LLNEQA---QQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRL 1122
Cdd:COG1196  319 EELEEelaeLEEELEeleEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                        170
                 ....*....|....*....
gi 38348729 1123 EENIHDAESALRMAAKDKE 1141
Cdd:COG1196  399 AAQLEELEEAEEALLERLE 417
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
46-284 2.06e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.27  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    46 KKEKLEittkhnAELASYESQIAKLRSEVEKGEALRQsleydlAVARKEAGLGRR-AAEERLAEAH-RIQEK------LC 117
Cdd:PRK02224  476 RVEELE------AELEDLEEEVEEVEERLERAEDLVE------AEDRIERLEERReDLEELIAERReTIEEKreraeeLR 543
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   118 AQNSELQAKTNETEKAFQTSQQKwKEECRR----FEHDLEERDNMIQNCNREYDLLmKEKSRLEKTLQEALEKHQrEKNE 193
Cdd:PRK02224  544 ERAAELEAEAEEKREAAAEAEEE-AEEAREevaeLNSKLAELKERIESLERIRTLL-AAIADAEDEIERLREKRE-ALAE 620
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   194 MESHIRETaLEEFR-----LQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHmdcsDLLRRQTSELEFSTQREER 268
Cdd:PRK02224  621 LNDERRER-LAEKRerkreLEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREER----DDLQAEIGAVENELEELEE 695
                         250
                  ....*....|....*.
gi 38348729   269 LRKEFEATTLRVRKLE 284
Cdd:PRK02224  696 LRERREALENRVEALE 711
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
23-537 2.87e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.89  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     23 KQILKNETELDItdnLRKKLHWAKKEKL-EITTKHNAELASYESQIAKLRSEVEKGEALRQSLeydlavARKEAGLGRRA 101
Cdd:TIGR00606  279 KQMEKDNSELEL---KMEKVFQGTDEQLnDLYHNHQRTVREKERELVDCQRELEKLNKERRLL------NQEKTELLVEQ 349
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    102 AEERLaEAHRIQEKLCAQNSELQAKTNETEkafqtsqqkwkeeCRRFEHDLE---ERDNMIQNCNREYDLLMKEKSRLEK 178
Cdd:TIGR00606  350 GRLQL-QADRHQEHIRARDSLIQSLATRLE-------------LDGFERGPFserQIKNFHTLVIERQEDEAKTAAQLCA 415
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    179 TLQEALEKHQREKNEMESHIRETAlEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSE 258
Cdd:TIGR00606  416 DLQSKERLKQEQADEIRDEKKGLG-RTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNS 494
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    259 LEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQL-------RIRDLEGALQVEKASQAEAVADLEI 331
Cdd:TIGR00606  495 LTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKdkmdkdeQIRKIKSRHSDELTSLLGYFPNKKQ 574
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    332 IKNEFKEVEsayeREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRL------QYNEKSCSELQEELVM 405
Cdd:TIGR00606  575 LEDWLHSKS----KEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEK 650
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    406 AKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLE-DASNEEKACNEL-- 482
Cdd:TIGR00606  651 SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTEsELKKKEKRRDEMlg 730
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729    483 --DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHC 537
Cdd:TIGR00606  731 laPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 787
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
60-316 3.41e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 3.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   60 LASYESQIAKLRSEVEKGEALRQSLEydlavARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQq 139
Cdd:COG4913  612 LAALEAELAELEEELAEAEERLEALE-----AELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSD- 685
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  140 kwkeECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR------EKNEMESHIRETALEEFRLQEEQW 213
Cdd:COG4913  686 ----DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDElqdrleAAEDLARLELRALLEERFAAALGD 761
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  214 EAERRELQFIVQEQDTAVQNMHKKVEKLETE--------HMDCSDLlrrqTSELEFSTQREERLRK-------EFEAttl 278
Cdd:COG4913  762 AVERELRENLEERIDALRARLNRAEEELERAmrafnrewPAETADL----DADLESLPEYLALLDRleedglpEYEE--- 834
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 38348729  279 RVRK-LEENIEAERaAHLESKFNSEI--IQLRIRDLEGALQ 316
Cdd:COG4913  835 RFKElLNENSIEFV-ADLLSKLRRAIreIKERIDPLNDSLK 874
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
103-560 4.59e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 4.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  103 EERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQE 182
Cdd:COG4717   48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  183 ALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHmdcSDLLRRQTSELEFS 262
Cdd:COG4717  128 LPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLAT---EEELQDLAEELEEL 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  263 TQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEF------ 336
Cdd:COG4717  205 QQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVlflvlg 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  337 --KEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLv 414
Cdd:COG4717  285 llALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  415 eTCENNVKELESILDSFTVSG--QWTSGIHKDKDKppsfsvvlERLRRTLTDYQNKLEDASNEEKAcnelDSTKQKIDSH 492
Cdd:COG4717  364 -QLEELEQEIAALLAEAGVEDeeELRAALEQAEEY--------QELKEELEELEEQLEELLGELEE----LLEALDEEEL 430
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  493 TKNIKELQDKLADVNKELSHLHTKCADREALISTLK--VELQNVLHCWEKEKAQAAQSESELQKLSQAFH 560
Cdd:COG4717  431 EEELEELEEELEELEEELEELREELAELEAELEQLEedGELAELLQELEELKAELRELAEEWAALKLALE 500
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
472-691 5.20e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 5.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  472 ASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVlhcwEKEKAQAAQSESE 551
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL----EAELAELEKEIAE 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  552 LQKLSQAFHKDAEEKLTFLHTLYQHlvAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNK 631
Cdd:COG4942   95 LRAELEAQKEELAELLRALYRLGRQ--PPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  632 SDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELfLEVQKRAQKFQEIAEK 691
Cdd:COG4942  173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-AELQQEAEELEALIAR 231
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
11-348 9.24e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.96  E-value: 9.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    11 DTQRLKIASLDvKQILKNETELDITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALR--------- 81
Cdd:PRK02224  380 EDRREEIEELE-EEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLeagkcpecg 458
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    82 QSLEYDLAVARKEaglgrrAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAfqtsqqkwKEECRRFEHDLEERDNMIQn 161
Cdd:PRK02224  459 QPVEGSPHVETIE------EDRERVEELEAELEDLEEEVEEVEERLERAEDL--------VEAEDRIERLEERREDLEE- 523
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   162 cnreydLLMKEKSRLEKTlQEALEKHQREKNEMESHIRETAlEEFRLQEEQWEAERRELQFIVQEQdTAVQNMHKKVEKL 241
Cdd:PRK02224  524 ------LIAERRETIEEK-RERAEELRERAAELEAEAEEKR-EAAAEAEEEAEEAREEVAELNSKL-AELKERIESLERI 594
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   242 ETEHMDCSDL------LRRQTSEL-EFSTQREERLRKEFEattlRVRKLEENIEAERAAHLESKfnSEIIQLRIRDLEGA 314
Cdd:PRK02224  595 RTLLAAIADAedeierLREKREALaELNDERRERLAEKRE----RKRELEAEFDEARIEEARED--KERAEEYLEQVEEK 668
                         330       340       350
                  ....*....|....*....|....*....|....
gi 38348729   315 LQVEKASQAEAVADLEIIKNEFKEVESAYEREKH 348
Cdd:PRK02224  669 LDELREERDDLQAEIGAVENELEELEELRERREA 702
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
50-336 9.28e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 46.60  E-value: 9.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     50 LEITTKHNAELasyESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLgrraAEERLAEAHRIQEKLCAQNSELQAKTNE 129
Cdd:pfam19220  127 LAAETEQNRAL---EEENKALREEAQAAEKALQRAEGELATARERLAL----LEQENRRLQALSEEQAAELAELTRRLAE 199
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    130 TEKAFQTSQQKWKEECRRFEHDLEERdnmiqncnreydllmkekSRLEKTLQEALEKHQREKNEM-----ESHIRETALE 204
Cdd:pfam19220  200 LETQLDATRARLRALEGQLAAEQAER------------------ERAEAQLEEAVEAHRAERASLrmkleALTARAAATE 261
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    205 EF---------RLQEEQWEAERRELQFIVqEQDTAvqnmHKKVEKLETEHMDcsdlLRRQTSELEFS----TQREERLRK 271
Cdd:pfam19220  262 QLlaearnqlrDRDEAIRAAERRLKEASI-ERDTL----ERRLAGLEADLER----RTQQFQEMQRAraelEERAEMLTK 332
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38348729    272 EFEATTLRVRKLEENIEA--ERAAHLESKFNSEIIQL--RIRDLEGALQVEKASQAEAVADLEIIKNEF 336
Cdd:pfam19220  333 ALAAKDAALERAEERIASlsDRIAELTKRFEVERAALeqANRRLKEELQRERAERALAQGALEIARESR 401
PTZ00121 PTZ00121
MAEBL; Provisional
62-408 1.09e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    62 SYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKlcAQNSELQAKTNETEKafQTSQQKW 141
Cdd:PTZ00121 1169 ARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAED--AKKAEAVKKAEEAKK--DAEEAKK 1244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   142 KEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIREtALEEFRLQEEQWEAErrELQ 221
Cdd:PTZ00121 1245 AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKK-ADEAKKKAEEAKKAD--EAK 1321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   222 FIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHlESKFNS 301
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD-EAKKKA 1400
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   302 EIIQLRIRDLEGALQVEKAS-----QAEAVADLEIIKNEFKEVESAYEREKhNAQESFAKLNLLEK-EYFSKNKKLNEDI 375
Cdd:PTZ00121 1401 EEDKKKADELKKAAAAKKKAdeakkKAEEKKKADEAKKKAEEAKKADEAKK-KAEEAKKAEEAKKKaEEAKKADEAKKKA 1479
                         330       340       350
                  ....*....|....*....|....*....|...
gi 38348729   376 EEQKKViIDLSKRLQYNEKSCSELQEELVMAKK 408
Cdd:PTZ00121 1480 EEAKKA-DEAKKKAEEAKKKADEAKKAAEAKKK 1511
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
47-724 1.10e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.98  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     47 KEKLEITTkhnAELASYESQIAKLRSEVEKGEALRQSLEYDL-AVARKEAGLGRRAAEERLAEAHRIQE--KLCAQNSEL 123
Cdd:TIGR02169  293 KEKIGELE---AEIASLERSIAEKERELEDAEERLAKLEAEIdKLLAEIEELEREIEEERKRRDKLTEEyaELKEELEDL 369
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    124 QAKTNETEKAFQTSQQKWKEECRRfehdleerdnmIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMEShiRETAL 203
Cdd:TIGR02169  370 RAELEEVDKEFAETRDELKDYREK-----------LEKLKREINELKRELDRLQEELQRLSEELADLNAAIAG--IEAKI 436
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    204 EEFrlqeeqwEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELefstqreERLRKEFEATTLRVRKL 283
Cdd:TIGR02169  437 NEL-------EEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL-------SKLQRELAEAEAQARAS 502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    284 EENIEAERAAHLESKFNSEIIQLRIRDL-----EGALQVEKAsqAEAVADLEIIKNEFKEVES-AYEREKHNAQESFAKL 357
Cdd:TIGR02169  503 EERVRGGRAVEEVLKASIQGVHGTVAQLgsvgeRYATAIEVA--AGNRLNNVVVEDDAVAKEAiELLKRRKAGRATFLPL 580
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    358 NLLekeyfsKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSE----LQEELVM-----AKKHQA-FLVETCENnvkelesi 427
Cdd:TIGR02169  581 NKM------RDERRDLSILSEDGVIGFAVDLVEFDPKYEPAfkyvFGDTLVVedieaARRLMGkYRMVTLEG-------- 646
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    428 lDSFTVSGQWTSGIHKDKDK---PPSFSVVLERLRRTLTDYQNKLEDASNE-EKACNELDSTKQKIDSHTKNIKELQDKL 503
Cdd:TIGR02169  647 -ELFEKSGAMTGGSRAPRGGilfSRSEPAELQRLRERLEGLKRELSSLQSElRRIENRLDELSQELSDASRKIGEIEKEI 725
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    504 ADVNKELSHLHTKCADREALISTLKVELQNVlhcwekeKAQAAQSESELQKLSQAFHKDAEEkltflhtlyqhlvagcvl 583
Cdd:TIGR02169  726 EQLEQEEEKLKERLEELEEDLSSLEQEIENV-------KSELKELEARIEELEEDLHKLEEA------------------ 780
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    584 IKQPEGMLDKFSWSElcavLQENVDALIADLNRANEKIRHLEYICKNKSdtmRELQQTQEDTFTKVAEQIKAQEscwhrQ 663
Cdd:TIGR02169  781 LNDLEARLSHSRIPE----IQAELSKLEEEVSRIEARLREIEQKLNRLT---LEKEYLEKEIQELQEQRIDLKE-----Q 848
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38348729    664 KKELELQYSELflevQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKLLSQTQREQ 724
Cdd:TIGR02169  849 IKSIEKEIENL----NGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKI 905
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
457-1133 1.13e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    457 RLRRTLTDYQnKLEDASNE-EKACNELDSTKQKidshTKNIKELQDKLADVNKELSHLHTKCADREalISTLKVELQNVL 535
Cdd:TIGR02168  180 KLERTRENLD-RLEDILNElERQLKSLERQAEK----AERYKELKAELRELELALLVLRLEELREE--LEELQEELKEAE 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    536 HCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVagcvLIKQPEGMLdkfswselcAVLQENVDALIADLN 615
Cdd:TIGR02168  253 EELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALAN----EISRLEQQK---------QILRERLANLERQLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    616 RANEKIRHLEyickNKSDTMRE---LQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEI---A 689
Cdd:TIGR02168  320 ELEAQLEELE----SKLDELAEelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqI 395
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    690 EKNMEKLNHIEKSHEQLvleNSHFKKLLSQTQREQMSLLAAcalmagALYPLYSRSCALSTQRDFLQEQVNTFELFKLEI 769
Cdd:TIGR02168  396 ASLNNEIERLEARLERL---EDRRERLQQEIEELLKKLEEA------ELKELQAELEELEEELEELQEELERLEEALEEL 466
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    770 RTLAQALSTVEEKKQEEAKMKKKTFKGLIRIFR------KGVIAVLA-ANRLKILGQSCASLFTWMESFK--------EG 834
Cdd:TIGR02168  467 REELEEAEQALDAAERELAQLQARLDSLERLQEnlegfsEGVKALLKnQSGLSGILGVLSELISVDEGYEaaieaalgGR 546
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    835 IGMLVCTGEPQDKhkfpkhqkeqlrclQALSWLTSSDLLAAiisSMAELQDVIGKADPNSR---ICGHLLIGAAKNSFAK 911
Cdd:TIGR02168  547 LQAVVVENLNAAK--------------KAIAFLKQNELGRV---TFLPLDSIKGTEIQGNDreiLKNIEGFLGVAKDLVK 609
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    912 LMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKV---NTLALKYGL--RGHVPITKSTASLQKQILGFTQRLHAA 986
Cdd:TIGR02168  610 FDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVtldGDLVRPGGVitGGSAKTNSSILERRREIEELEEKIEEL 689
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    987 EVERRSLRLEVTEFKRSVNEMKKELDKAQ----GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQ 1062
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEELEEELEQLRkeleELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEER 769
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1063 LQELNYKLELHSSEEADKNQ----------TLGEAVKSLSEAKMELRRKDQSLRQ-----------LNRHLTQLEQDKRR 1121
Cdd:TIGR02168  770 LEEAEEELAEAEAEIEELEAqieqlkeelkALREALDELRAELTLLNEEAANLRErleslerriaaTERRLEDLEEQIEE 849
                          730
                   ....*....|..
gi 38348729   1122 LEENIHDAESAL 1133
Cdd:TIGR02168  850 LSEDIESLAAEI 861
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
70-559 1.49e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 46.26  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     70 LRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFE 149
Cdd:pfam15921  262 LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    150 HDLEERDNMIQNCNREY-------DLLMKEKSRLEKTLQEAL-EKHQREKN---EMESHIR---------------ETAL 203
Cdd:pfam15921  342 DKIEELEKQLVLANSELtearterDQFSQESGNLDDQLQKLLaDLHKREKElslEKEQNKRlwdrdtgnsitidhlRREL 421
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    204 EEFRLQEEQWEA----ERRELQFIVQEQDTAVQNMHKKVEK---LETEHMDCSDLLRRQTSELEFSTQREERLRKEFEAT 276
Cdd:pfam15921  422 DDRNMEVQRLEAllkaMKSECQGQMERQMAAIQGKNESLEKvssLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDL 501
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    277 TLRVRKLEENIEAERA--AHLESKFNSEIIQLR--------IRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYERE 346
Cdd:pfam15921  502 TASLQEKERAIEATNAeiTKLRSRVDLKLQELQhlknegdhLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQH 581
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    347 KHNAQESFAKLNLLEKEYFSKNKKLNE-DIEEQKKviidlSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELE 425
Cdd:pfam15921  582 GRTAGAMQVEKAQLEKEINDRRLELQEfKILKDKK-----DAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERD 656
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    426 SILDSFTVSGQWTSGIHKD--------KDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKAC---------------NEL 482
Cdd:pfam15921  657 QLLNEVKTSRNELNSLSEDyevlkrnfRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMegsdghamkvamgmqKQI 736
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    483 DSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQN------VLHCWEKE-KAQAAQSESELQKL 555
Cdd:pfam15921  737 TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKmageleVLRSQERRlKEKVANMEVALDKA 816

                   ....
gi 38348729    556 SQAF 559
Cdd:pfam15921  817 SLQF 820
PTZ00121 PTZ00121
MAEBL; Provisional
164-721 1.49e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   164 REYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEfrlqeeqwEAERRELQFIVQEQDTAVQNMHKKVEKLET 243
Cdd:PTZ00121 1077 KDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAE--------EAKKKAEDARKAEEARKAEDARKAEEARKA 1148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   244 EHMDCSDLLRR--QTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESKFNSEiiqlRIRDLEGALQVEKAS 321
Cdd:PTZ00121 1149 EDAKRVEIARKaeDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAE----EERKAEEARKAEDAK 1224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   322 QAEAVADLEIIKnefKEVESAYEREKHNAQESFAKLNLLEKEYFSKN---------------------KKLNEDIEEQKK 380
Cdd:PTZ00121 1225 KAEAVKKAEEAK---KDAEEAKKAEEERNNEEIRKFEEARMAHFARRqaaikaeearkadelkkaeekKKADEAKKAEEK 1301
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   381 VIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESIldsftvsgqwTSGIHKDKDKPPSFSVVLERLRR 460
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA----------KAEAEAAADEAEAAEEKAEAAEK 1371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   461 TLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQdKLADVNKELSHLHTKCAD-REALISTLKVElqnvlhcwE 539
Cdd:PTZ00121 1372 KKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELK-KAAAAKKKADEAKKKAEEkKKADEAKKKAE--------E 1442
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   540 KEKAQAAQSESELQKLSQAFHKDAEE--KLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDaliaDLNRA 617
Cdd:PTZ00121 1443 AKKADEAKKKAEEAKKAEEAKKKAEEakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD----EAKKA 1518
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   618 NEkirhleyicKNKSDTMRELQQTQEDTFTKVAEQIKAQESCwhRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLN 697
Cdd:PTZ00121 1519 EE---------AKKADEAKKAEEAKKADEAKKAEEKKKADEL--KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587
                         570       580
                  ....*....|....*....|....
gi 38348729   698 HIEKSHEQLVLENSHFKKLLSQTQ 721
Cdd:PTZ00121 1588 KAEEARIEEVMKLYEEEKKMKAEE 1611
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
174-791 1.81e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.12  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    174 SRLEKTLQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAER--RELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDL 251
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKalEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    252 LRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEA---ERAAHLESKFNSEIIQLRIRDlegaLQVEKASQAEAVAD 328
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKlqeEELKLLAKEEEELKSELLKLE----RRKVDDEEKLKESE 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    329 LEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 408
Cdd:pfam02463  321 KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELK 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    409 HQafLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDstKQK 488
Cdd:pfam02463  401 SE--EEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDL--LKE 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    489 IDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAE-EKL 567
Cdd:pfam02463  477 TQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEvSAT 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    568 TFLHTLYQHLVAGCVLIKQPEGMLDKFSWSELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQ-QTQEDTF 646
Cdd:pfam02463  557 ADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGIlKDTELTK 636
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    647 TKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKKlLSQTQREQMS 726
Cdd:pfam02463  637 LKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE-QREKEELKKL 715
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38348729    727 LLAACALMAGALYPLYSRScalSTQRDFLQEQVNTFELFKLEIRTlaQALSTVEEKKQEEAKMKK 791
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKI---NEELKLLKQKIDEEEEEEEKSRL--KKEEKEEEKSELSLKEKE 775
PTZ00121 PTZ00121
MAEBL; Provisional
55-715 2.11e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    55 KHNAELASYESQIaKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAE-AHRIQEKLCAQNSELQAKTNETEKA 133
Cdd:PTZ00121 1085 EDNRADEATEEAF-GKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEdARKAEEARKAEDAKRVEIARKAEDA 1163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   134 FQTSQQKWKEECRRFEHDLE-------ERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESHIRETALEEF 206
Cdd:PTZ00121 1164 RKAEEARKAEDAKKAEAARKaeevrkaEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAK 1243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   207 RLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTselefSTQREERLRKEFEATtlrvRKLEEN 286
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-----EAKKAEEKKKADEAK----KKAEEA 1314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   287 IEAERAAHL--ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKlnlleKEY 364
Cdd:PTZ00121 1315 KKADEAKKKaeEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK-----AEE 1389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   365 FSKNKKLNEDIEEQKKVIIDLSKRLQYNEKScselqEELvmakKHQAFLVETCENNVKELESILDSFTVSGQwtsgiHKD 444
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKKADELKKAAAAKKKA-----DEA----KKKAEEKKKADEAKKKAEEAKKADEAKKK-----AEE 1455
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   445 KDKPPSFSVVLERLRRTlTDYQNKLEDASNEEKACNELDSTKQKIDSHTKniKELQDKLADvnkELSHLHTKCADREALI 524
Cdd:PTZ00121 1456 AKKAEEAKKKAEEAKKA-DEAKKKAEEAKKADEAKKKAEEAKKKADEAKK--AAEAKKKAD---EAKKAEEAKKADEAKK 1529
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   525 STLKVELQNVLHCWEKEKAQAAQSESELQKLSQAfhKDAEEK----------LTFLHTLYQHLVAGCVLIKQPEGMLDKF 594
Cdd:PTZ00121 1530 AEEAKKADEAKKAEEKKKADELKKAEELKKAEEK--KKAEEAkkaeedknmaLRKAEEAKKAEEARIEEVMKLYEEEKKM 1607
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   595 SWSELCAVLQENVDAliADLNRANEKIRHLEYICKNKSDTMR---ELQQTQEDTFTKVAEQIKAQEscwHRQKKELELQY 671
Cdd:PTZ00121 1608 KAEEAKKAEEAKIKA--EELKKAEEEKKKVEQLKKKEAEEKKkaeELKKAEEENKIKAAEEAKKAE---EDKKKAEEAKK 1682
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 38348729   672 SElflEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLVLENSHFKK 715
Cdd:PTZ00121 1683 AE---EDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKK 1723
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
143-557 2.30e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.48  E-value: 2.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    143 EECRRFEHDLEER----DNMIQNCNREYDLLMKEKSRLEKTLQEAL--EKHQREKNEMESHIRETALEEFRLQEEQWEAE 216
Cdd:pfam05483  264 EESRDKANQLEEKtklqDENLKELIEKKDHLTKELEDIKMSLQRSMstQKALEEDLQIATKTICQLTEEKEAQMEELNKA 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    217 RRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEEnIEAERAAHLE 296
Cdd:pfam05483  344 KAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKK-ILAEDEKLLD 422
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    297 SKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIE 376
Cdd:pfam05483  423 EKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENK 502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    377 EQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKELESILDSFtvsgqwtsgIHKDKDKPPSFSVVLE 456
Cdd:pfam05483  503 ELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEF---------IQKGDEVKCKLDKSEE 573
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    457 RLRRTLTDYQNKLEDASNEEKACNELdstKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLH 536
Cdd:pfam05483  574 NARSIEYEVLKKEKQMKILENKCNNL---KKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQ 650
                          410       420
                   ....*....|....*....|.
gi 38348729    537 CWEkEKAQAAQSESELQKLSQ 557
Cdd:pfam05483  651 KFE-EIIDNYQKEIEDKKISE 670
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
59-426 2.39e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.80  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    59 ELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAhriqeklcaqnsELQAKTNETEKAFQTSQ 138
Cdd:PRK02224  252 ELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEA------------GLDDADAEAVEARREEL 319
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   139 QKWKEECRRfehDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERR 218
Cdd:PRK02224  320 EDRDEELRD---RLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEE--AREAVEDRREEIEELEEEIE 394
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   219 ELQfivqeqdtavqnmhKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLEsk 298
Cdd:PRK02224  395 ELR--------------ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECG-- 458
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   299 fnseiiqlriRDLEGALQVEKASQ-----AEAVADLEIIKNEFKEVESAYEREKhNAQESFAKLNLLEKeyfsKNKKLNE 373
Cdd:PRK02224  459 ----------QPVEGSPHVETIEEdrervEELEAELEDLEEEVEEVEERLERAE-DLVEAEDRIERLEE----RREDLEE 523
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 38348729   374 DIEEQKKVIIDLSKRLQYNEKSCSELQEEL-----VMAKKHQAflVETCENNVKELES 426
Cdd:PRK02224  524 LIAERRETIEEKRERAEELRERAAELEAEAeekreAAAEAEEE--AEEAREEVAELNS 579
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
24-408 2.76e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.40  E-value: 2.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     24 QILKNETELDITDNLRKKLHWAKKEKLEITTkhnaELASYESQIAKLRSEVEKGEALRQSLEydlavarkeaglgrraae 103
Cdd:TIGR04523  298 SDLNNQKEQDWNKELKSELKNQEKKLEEIQN----QISQNNKIISQLNEQISQLKKELTNSE------------------ 355
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    104 erlAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQqKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEA 183
Cdd:TIGR04523  356 ---SENSEKQRELEEKQNEIEKLKKENQSYKQEIK-NLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERL 431
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    184 LEKHQREKNEMEShiretaLEEfrlQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFST 263
Cdd:TIGR04523  432 KETIIKNNSEIKD------LTN---QDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLN 502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    264 QREERLRKEFEATTLRVRKLEENIEaeraahlesKFNSEI--IQLRIRDLEGalqvekasqaeavadlEIIKNEFKEVES 341
Cdd:TIGR04523  503 EEKKELEEKVKDLTKKISSLKEKIE---------KLESEKkeKESKISDLED----------------ELNKDDFELKKE 557
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729    342 AYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKK 408
Cdd:TIGR04523  558 NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKK 624
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
20-557 3.72e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 3.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     20 LDVKQILKNETELditdnlrKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKE----- 94
Cdd:TIGR04523  114 NDKEQKNKLEVEL-------NKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEklniq 186
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     95 -----AGLGRRAAEERLAEAHRIQEK---LCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREY 166
Cdd:TIGR04523  187 knidkIKNKLLKLELLLSNLKKKIQKnksLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIK 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    167 DLLMKEKSRLEKT------LQEALEKHQREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK 240
Cdd:TIGR04523  267 KQLSEKQKELEQNnkkikeLEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQ 346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    241 LETEhmdcsdllrRQTSELEFSTQREERLRKEFEAttlrvrkleENIEAERAAHLESKFNSEIiqlRIRDLEGALQVEKA 320
Cdd:TIGR04523  347 LKKE---------LTNSESENSEKQRELEEKQNEI---------EKLKKENQSYKQEIKNLES---QINDLESKIQNQEK 405
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    321 SQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKN---KKLNEDIEEQKKVIIDLSKRLQYNEKSCS 397
Cdd:TIGR04523  406 LNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEliiKNLDNTRESLETQLKVLSRSINKIKQNLE 485
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    398 ELQEELVMAKKHQAFLVE---TCENNVKELESILDSFTVS-GQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDAS 473
Cdd:TIGR04523  486 QKQKELKSKEKELKKLNEekkELEEKVKDLTKKISSLKEKiEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDE 565
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    474 NEEkacnELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQ 553
Cdd:TIGR04523  566 KNK----EIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKN 641

                   ....
gi 38348729    554 KLSQ 557
Cdd:TIGR04523  642 KLKQ 645
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
174-565 4.35e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.67  E-value: 4.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    174 SRLEKTLQEaLEKHQREKNEMESHIRETALEEFRLQEEQWEAER-RELQFIVQEqdTAVQNMHKKVEKLETEHMDCSDLL 252
Cdd:TIGR02169  170 RKKEKALEE-LEEVEENIERLDLIIDEKRQQLERLRREREKAERyQALLKEKRE--YEGYELLKEKEALERQKEAIERQL 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    253 RRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAEraahleskfnSEIIQLRIRDLEGALQVEKASQAEAVAdleii 332
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDL----------GEEEQLRVKEKIGELEAEIASLERSIA----- 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    333 knefkevesAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQynekscsELQEELvmakkhqaf 412
Cdd:TIGR02169  312 ---------EKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYA-------ELKEEL--------- 366
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    413 lvetcENNVKELESIldsftvsgqwtsgihkdkdkppsfSVVLERLRRTLTDYQNKLEDasneekacneldsTKQKIDSH 492
Cdd:TIGR02169  367 -----EDLRAELEEV------------------------DKEFAETRDELKDYREKLEK-------------LKREINEL 404
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38348729    493 TKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEE 565
Cdd:TIGR02169  405 KRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEE 477
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
178-402 4.80e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  178 KTLQEALEKHQREKNEMESHIRETaleefrlqeeqwEAERRELQFIVQEQDTAVQNMHKKVEKLETEhmdcsdlLRRQTS 257
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAAL------------KKEEKALLKQLAALERRIAALARRIRALEQE-------LAALEA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  258 ELEFSTQREERLRKEFEATTLRVRKLEENIE-AERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAvADLEIIKNEF 336
Cdd:COG4942   84 ELAELEKEIAELRAELEAQKEELAELLRALYrLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQA-EELRADLAEL 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348729  337 KEVESAYEREKhnaqesfAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEE 402
Cdd:COG4942  163 AALRAELEAER-------AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE 221
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
23-562 5.19e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   23 KQILKNETELDITDNLRKKL-HWAKKEKLEI----TTKHNAELASYESQIAKLRSEVEKGEALRQSLEydlaVARKEAGL 97
Cdd:COG4913  262 ERYAAARERLAELEYLRAALrLWFAQRRLELleaeLEELRAELARLEAELERLEARLDALREELDELE----AQIRGNGG 337
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   98 GR--------RAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEEcrrfehdLEERDNMIQNCNREYDLL 169
Cdd:COG4913  338 DRleqlereiERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAAL-------LEALEEELEALEEALAEA 410
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  170 MKEKSRlektLQEALEKHQREKNEME---SHIREtALEEFRLQ-EEQWEAERRELQFI-----VQEQDTAVQNmhkKVEK 240
Cdd:COG4913  411 EAALRD----LRRELRELEAEIASLErrkSNIPA-RLLALRDAlAEALGLDEAELPFVgelieVRPEEERWRG---AIER 482
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  241 letehmdcsdLLRRQTSELEFSTQREERLRKEFEATTLRVR----KLEENIEAERAAHLESKFNSEIIQLRIRDLEGALQ 316
Cdd:COG4913  483 ----------VLGGFALTLLVPPEHYAAALRWVNRLHLRGRlvyeRVRTGLPDPERPRLDPDSLAGKLDFKPHPFRAWLE 552
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  317 VEKASQAEA--VADLEiiknEFKEVESA----------YEREKHNAQESF-----------AKLNLLEKEYfsknKKLNE 373
Cdd:COG4913  553 AELGRRFDYvcVDSPE----ELRRHPRAitragqvkgnGTRHEKDDRRRIrsryvlgfdnrAKLAALEAEL----AELEE 624
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  374 DIEEQKKVIIDLSKRLQYNEKSCSELQ--EELVMAKKHQAFLVETCENNVKELESILDSftvsgqwtsgihkdkdkppsf 451
Cdd:COG4913  625 ELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAEREIAELEAELERLDAS--------------------- 683
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  452 SVVLERLRRTLTDYQNKLEDASNEEKACN-ELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHTKCAD-------REAL 523
Cdd:COG4913  684 SDDLAALEEQLEELEAELEELEEELDELKgEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEerfaaalGDAV 763
                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 38348729  524 ISTLKVELQNVLhcwEKEKAQAAQSESELQKLSQAFHKD 562
Cdd:COG4913  764 ERELRENLEERI---DALRARLNRAEEELERAMRAFNRE 799
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
344-566 5.52e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  344 EREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCENNVKE 423
Cdd:COG4942   26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  424 LESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKAcnELDSTKQKIDSHTKNIKELQDKL 503
Cdd:COG4942  106 LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLA--ELAALRAELEAERAELEALLAEL 183
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38348729  504 ADVNKELSHLHtkcADREALISTLKVELQNVlhcwEKEKAQAAQSESELQKLSQAFHKDAEEK 566
Cdd:COG4942  184 EEERAALEALK---AERQKLLARLEKELAEL----AAELAELQQEAEELEALIARLEAEAAAA 239
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1006-1176 5.89e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 5.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1006 EMKKELD--KAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQT 1083
Cdd:COG1196  217 ELKEELKelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1084 LGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKV---RDQ 1160
Cdd:COG1196  297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAeaeLAE 376
                        170
                 ....*....|....*.
gi 38348729 1161 ISLSWSAASRNDFTLQ 1176
Cdd:COG1196  377 AEEELEELAEELLEAL 392
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
99-277 7.54e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.96  E-value: 7.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     99 RRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDlEERDNMIQNCNREYDLLMKEKSRLEK 178
Cdd:pfam17380  438 RRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAE-EQRRKILEKELEERKQAMIEEERKRK 516
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    179 TLQEALEKHQREKNEMEShiRETALEEFRLQEEQWEAERrelqfiVQEQDTAVQNMHKKVEKLETEHMdcsdlLRRQTSE 258
Cdd:pfam17380  517 LLEKEMEERQKAIYEEER--RREAEEERRKQQEMEERRR------IQEQMRKATEERSRLEAMERERE-----MMRQIVE 583
                          170
                   ....*....|....*....
gi 38348729    259 lefstqrEERLRKEFEATT 277
Cdd:pfam17380  584 -------SEKARAEYEATT 595
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
169-403 8.06e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 8.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  169 LMKEKSRLEKTLQEALEkHQREKNEMESHIRET-----ALEEFRLQEEQWEAERRELQFIVQEQDTA-VQNMHKKVEKLE 242
Cdd:COG4913  216 YMLEEPDTFEAADALVE-HFDDLERAHEALEDAreqieLLEPIRELAERYAAARERLAELEYLRAALrLWFAQRRLELLE 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  243 TEhmdcsdlLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLESkfnseiIQLRIRDLEGALQVEKASQ 322
Cdd:COG4913  295 AE-------LEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQ------LEREIERLERELEERERRR 361
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  323 AEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEyfsknkkLNEDIEEQKKVIIDLSKRLQynekscsELQEE 402
Cdd:COG4913  362 ARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEA-------LEEALAEAEAALRDLRRELR-------ELEAE 427

                 .
gi 38348729  403 L 403
Cdd:COG4913  428 I 428
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
65-418 8.58e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 43.94  E-value: 8.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     65 SQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWK-- 142
Cdd:pfam05483  296 KELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEkn 375
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    143 ------------------EECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQR-----EKNEMESHIR 199
Cdd:pfam05483  376 edqlkiitmelqkksselEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQElifllQAREKEIHDL 455
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    200 ETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEH----MDCSDL---LRRQTSELEFSTQREERLRKE 272
Cdd:pfam05483  456 EIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENkeltQEASDMtleLKKHQEDIINCKKQEERMLKQ 535
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    273 FEATTLRVRKLEENIEAERAahlESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE 352
Cdd:pfam05483  536 IENLEEKEMNLRDELESVRE---EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEE 612
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348729    353 SFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVETCE 418
Cdd:pfam05483  613 LHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVE 678
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
108-795 1.35e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.11  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    108 EAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKeksrLEKTLQeALEKH 187
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMK----LDNEIK-ALKSR 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    188 QREKNEMESHIRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEhmdcSDLLRRQTSELEFSTQR-- 265
Cdd:TIGR00606  278 KKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKE----RRLLNQEKTELLVEQGRlq 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    266 ------------------EERLRKEFE--------------ATTLRVRKLEEniEAERAAHLESKFNSEI---------I 304
Cdd:TIGR00606  354 lqadrhqehirardsliqSLATRLELDgfergpfserqiknFHTLVIERQED--EAKTAAQLCADLQSKErlkqeqadeI 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    305 QLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQE---SFAKLNLLEKEYFSKNKKLNEDIEEQKKV 381
Cdd:TIGR00606  432 RDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQElrkAERELSKAEKNSLTETLKKEVKSLQNEKA 511
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    382 IIDLSKRL------QYNEKSCSELQEELVMAKKHQAF--LVETCENNVKELESILDSFTVSGQWTSGIH-KDKDKPPS-- 450
Cdd:TIGR00606  512 DLDRKLRKldqemeQLNHHTTTRTQMEMLTKDKMDKDeqIRKIKSRHSDELTSLLGYFPNKKQLEDWLHsKSKEINQTrd 591
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    451 ------------------FSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLADVNKELSH 512
Cdd:TIGR00606  592 rlaklnkelasleqnknhINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQ 671
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    513 LHTK---CADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEG 589
Cdd:TIGR00606  672 LTDEnqsCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRN 751
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    590 MLDKFSWSelCAVLQENVDALIADLNRANEKIRHLEyICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCwhrqkkELEL 669
Cdd:TIGR00606  752 KLQKVNRD--IQRLKNDIEEQETLLGTIMPEEESAK-VCLTDVTIMERFQMELKDVERKIAQQAAKLQGS------DLDR 822
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    670 QYSELFLEVQKRAQKFQEIAEKNMEKLNHIEKSHEQLvlenSHFKKLLSQTQREQMSL---LAACALMAGALYPLYSRSC 746
Cdd:TIGR00606  823 TVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQI----QHLKSKTNELKSEKLQIgtnLQRRQQFEEQLVELSTEVQ 898
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 38348729    747 ALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFK 795
Cdd:TIGR00606  899 SLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIK 947
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
982-1141 1.46e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  982 RLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQ----GLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLN 1057
Cdd:COG1196  226 EAELLLLKLRELEAELEELEAELEELEAELEELEaelaELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIA 305
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1058 EQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAA 1137
Cdd:COG1196  306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385

                 ....
gi 38348729 1138 KDKE 1141
Cdd:COG1196  386 EELL 389
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
976-1141 1.93e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  976 ILGFT--QRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLnefkqsklithekfeSACEELNNALLREEQAQ 1053
Cdd:COG4913  603 VLGFDnrAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAL---------------QRLAEYSWDEIDVASAE 667
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1054 MLLNEQAQQLQELnyklelhsseEADkNQTLGEAVKSLSEAKMELRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESAL 1133
Cdd:COG4913  668 REIAELEAELERL----------DAS-SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL 736

                 ....*...
gi 38348729 1134 RMAAKDKE 1141
Cdd:COG4913  737 EAAEDLAR 744
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
313-558 1.94e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  313 GALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYfsknKKLNEDIEEQKKVIIDLSKRLQYN 392
Cdd:COG3883    2 LALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEY----NELQAELEALQAEIDKLQAEIAEA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  393 EKSCSELQEELvmakKHQAFLVETCENNVKELESILDSftvsgqwtsgihkdkdkpPSFSVVLERL--RRTLTDYQNKLE 470
Cdd:COG3883   78 EAEIEERREEL----GERARALYRSGGSVSYLDVLLGS------------------ESFSDFLDRLsaLSKIADADADLL 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  471 DASNEEKAcnELDSTKQKIDshtKNIKELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSES 550
Cdd:COG3883  136 EELKADKA--ELEAKKAELE---AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEA 210

                 ....*...
gi 38348729  551 ELQKLSQA 558
Cdd:COG3883  211 AAAAAAAA 218
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
58-307 2.10e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   58 AELASYESQIAKLRSEVEKGEALRQSLEYDLAvarkeaglgrrAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTS 137
Cdd:COG4942   27 AELEQLQQEIAELEKELAALKKEEKALLKQLA-----------ALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  138 QQKWKEEcrrfEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEmeshiRETALEEFRLQEEQWEAER 217
Cdd:COG4942   96 RAELEAQ----KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA-----RREQAEELRADLAELAALR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  218 RELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLES 297
Cdd:COG4942  167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
                        250
                 ....*....|
gi 38348729  298 KFNSEIIQLR 307
Cdd:COG4942  247 GFAALKGKLP 256
PRK11281 PRK11281
mechanosensitive channel MscK;
967-1133 2.30e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   967 KSTASLQKQILGFTQRLhaaeverRSLRLEVTEFKRSVNEMKKE----LDKAQgLQMQLNEfkqskliTHEKFESACEEL 1042
Cdd:PRK11281   80 EETEQLKQQLAQAPAKL-------RQAQAELEALKDDNDEETREtlstLSLRQ-LESRLAQ-------TLDQLQNAQNDL 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  1043 N--NALL-----REEQAQMLLNEQAQQLQELNykLELHSSEEADKN-----QTLGEAVKSLSEAKMELRRKD-------Q 1103
Cdd:PRK11281  145 AeyNSQLvslqtQPERAQAALYANSQRLQQIR--NLLKGGKVGGKAlrpsqRVLLQAEQALLNAQNDLQRKSlegntqlQ 222
                         170       180       190
                  ....*....|....*....|....*....|
gi 38348729  1104 SLRQLNRHLTQLEQDkrRLEENIHDAESAL 1133
Cdd:PRK11281  223 DLLQKQRDYLTARIQ--RLEHQLQLLQEAI 250
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
970-1126 3.31e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  970 ASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEkfesaceelnnallrE 1049
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEALQKE---------------I 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729 1050 EQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKMELrrkDQSLRQLNRHLTQLEQDKRRLEENI 1126
Cdd:COG1579   99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEL---DEELAELEAELEELEAEREELAAKI 172
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
38-403 3.56e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   38 LRKKLHWAKKEKLEITTKHNaELASYESQIAKLRSEVEKGEALRQSLEYdlAVARKEAGLGRRAAEERLAEAHRIQEKLC 117
Cdd:COG4717   76 LEEELKEAEEKEEEYAELQE-ELEELEEELEELEAELEELREELEKLEK--LLQLLPLYQELEALEAELAELPERLEELE 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  118 AQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLE---KTLQEALEKHQREKNEM 194
Cdd:COG4717  153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEeelEEAQEELEELEEELEQL 232
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  195 ESHIRETALEEfRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEK----------LETEHMDCSDLLRRQTSELEFSTQ 264
Cdd:COG4717  233 ENELEAAALEE-RLKEARLLLLIAAALLALLGLGGSLLSLILTIAGvlflvlgllaLLFLLLAREKASLGKEAEELQALP 311
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  265 REERLRKEFEATTLRVRKLEENIEAERAAHLESKFnSEIIQL--RIRDLEGALQVEkASQAEAVADLEIIKNEFKE---- 338
Cdd:COG4717  312 ALEELEEEELEELLAALGLPPDLSPEELLELLDRI-EELQELlrEAEELEEELQLE-ELEQEIAALLAEAGVEDEEelra 389
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348729  339 -VESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEEL 403
Cdd:COG4717  390 aLEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREEL 455
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
986-1162 3.66e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    986 AEVERRSLRLEvtEFKRSVNEMKKELDKAQGLqmqLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQE 1065
Cdd:TIGR02169  674 AELQRLRERLE--GLKRELSSLQSELRRIENR---LDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   1066 LNYKLELHSSEEADKNQTLGEAVKSLSEAKMEL-----RRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDK 1140
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALndleaRLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828
                          170       180
                   ....*....|....*....|..
gi 38348729   1141 ECVANHMRAVENTLHKVRDQIS 1162
Cdd:TIGR02169  829 EYLEKEIQELQEQRIDLKEQIK 850
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
965-1138 3.74e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729  965 ITKSTASLQKQILGFTQRLHAAEVERRSLRLEVTEFKRSVNEMKKELDKAQG-LQMQLNEFKQSKLITHEKFESACEELN 1043
Cdd:COG4942   53 LLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEeLAELLRALYRLGRQPPLALLLSPEDFL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729 1044 ---------NALLREEQAQML-LNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKME----LRRKDQSLRQLN 1109
Cdd:COG4942  133 davrrlqylKYLAPARREQAEeLRADLAELAALRAELEAERAELEALLAELEEERAALEALKAErqklLARLEKELAELA 212
                        170       180
                 ....*....|....*....|....*....
gi 38348729 1110 RHLTQLEQDKRRLEENIHDAESALRMAAK 1138
Cdd:COG4942  213 AELAELQQEAEELEALIARLEAEAAAAAE 241
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
45-585 4.85e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.49  E-value: 4.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     45 AKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGLGRRAAEE--------------RLAEAH 110
Cdd:TIGR00618  383 TLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELcaaaitctaqceklEKIHLQ 462
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    111 RIQEKLCAQNSELQAKTNETEKAFQTSQ--QKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQ 188
Cdd:TIGR00618  463 ESAQSLKEREQQLQTKEQIHLQETRKKAvvLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLET 542
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    189 REKNemESHIRETALEEFRLQEEQWEAERRELQFIVQeQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREER 268
Cdd:TIGR00618  543 SEED--VYHQLTSERKQRASLKEQMQEIQQSFSILTQ-CDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLR 619
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    269 lRKEFEATTLRVRKLEENIEaERAAHLESKFNSEIIQLRIRDLEGALQVEKASQAEAvadLEIIKNEFKEVESAYEREKH 348
Cdd:TIGR00618  620 -KLQPEQDLQDVRLHLQQCS-QELALKLTALHALQLTLTQERVREHALSIRVLPKEL---LASRQLALQKMQSEKEQLTY 694
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    349 NaQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELvMAKKHQAFLVETCENNVKELESIL 428
Cdd:TIGR00618  695 W-KEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKEL-MHQARTVLKARTEAHFNNNEEVTA 772
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    429 DSFTvsgqwtsgihkdkdkppsfsvvLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIKELQDKLadVNK 508
Cdd:TIGR00618  773 ALQT----------------------GAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCET--LVQ 828
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38348729    509 ELSHLHTKCADREALISTLKVELQNVLHCwEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIK 585
Cdd:TIGR00618  829 EEEQFLSRLEEKSATLGEITHQLLKYEEC-SKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEITLYA 904
PRK01156 PRK01156
chromosome segregation protein; Provisional
16-515 6.10e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.04  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    16 KIASLDVKQILKNETELDITDNLRKKLHWAKKE---KLEITTKHNAELASYESQIAKLRSEVEKGEALRQ---SLEYDLA 89
Cdd:PRK01156  211 KSHSITLKEIERLSIEYNNAMDDYNNLKSALNElssLEDMKNRYESEIKTAESDLSMELEKNNYYKELEErhmKIINDPV 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    90 VARKEAGLGRRAAEERLAEAHRIQEKLCAQ----------NSELQAKTNETEKafqtsQQKWKEECRRFEHDLEERDNMI 159
Cdd:PRK01156  291 YKNRNYINDYFKYKNDIENKKQILSNIDAEinkyhaiikkLSVLQKDYNDYIK-----KKSRYDDLNNQILELEGYEMDY 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   160 QNCNREYDLLMKEksrlektlqeaLEKHQREKNEMESHIRETALEEFrLQEEQWEAERRELQFIVQEQDTAVQNMHKKVE 239
Cdd:PRK01156  366 NSYLKSIESLKKK-----------IEEYSKNIERMSAFISEILKIQE-IDPDAIKKELNEINVKLQDISSKVSSLNQRIR 433
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   240 KLETEHMDcsdlLRRQTSELE-----------FSTQREERLRKEFEATTLR----VRKLEENIEA--ERAAHLEsKFNSE 302
Cdd:PRK01156  434 ALRENLDE----LSRNMEMLNgqsvcpvcgttLGEEKSNHIINHYNEKKSRleekIREIEIEVKDidEKIVDLK-KRKEY 508
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   303 IIQLRIRDLEGALQVEKASQAEaVADLEIIKNEFKEVESAYEREKH--------------------NAQESFAKLNLLEK 362
Cdd:PRK01156  509 LESEEINKSINEYNKIESARAD-LEDIKIKINELKDKHDKYEEIKNrykslkledldskrtswlnaLAVISLIDIETNRS 587
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   363 EYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEElVMAKKHQAFLVETCENNVKELESILDSFtvsgqwTSGIH 442
Cdd:PRK01156  588 RSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENE-ANNLNNKYNEIQENKILIEKLRGKIDNY------KKQIA 660
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38348729   443 KDKDKPPSFSVVLERLRRTLTDYqNKLEDASNEEKAcnELDSTKQKIDSHTKNIKELQDKLADVNKELSHLHT 515
Cdd:PRK01156  661 EIDSIIPDLKEITSRINDIEDNL-KKSRKALDDAKA--NRARLESTIEILRTRINELSDRINDINETLESMKK 730
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
67-373 6.11e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.98  E-value: 6.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     67 IAKLRSEVEKGEALRQSLEYDLAvarKEAGLGRRAAEERLAEAHRIQEKlcaqnselQAKTNETEKAFQTSQQKWKEECR 146
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAEL---RLSHLHFGYKSDETLIASRQEER--------QETSAELNQLLRTLDDQWKEKRD 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    147 RFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQRE----KNEMESHIRETALEEFRLQEEQWEAERRElQF 222
Cdd:pfam12128  305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQlpswQSELENLEERLKALTGKHQDVTAKYNRRR-SK 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    223 IVQEQDTAVQNMHKKVEKL----ETEHMDCSDLLRRQTSElefstqreerLRKEFEATTLRVRKLEENIEaERAAHL--- 295
Cdd:pfam12128  384 IKEQNNRDIAGIKDKLAKIrearDRQLAVAEDDLQALESE----------LREQLEAGKLEFNEEEYRLK-SRLGELklr 452
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    296 --------ESKFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSK 367
Cdd:pfam12128  453 lnqatatpELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQ 532

                   ....*.
gi 38348729    368 NKKLNE 373
Cdd:pfam12128  533 AGTLLH 538
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
336-723 8.09e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 8.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    336 FKEVESAYEREKhnAQESFAKLNLLEKEYFSknkkLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVMAKKHQAFLVE 415
Cdd:TIGR02169  664 GGILFSRSEPAE--LQRLRERLEGLKRELSS----LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKE 737
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    416 TCENNVKELESILDsftvsgqwtsGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEkACNELDSTKQKIDSHTKN 495
Cdd:TIGR02169  738 RLEELEEDLSSLEQ----------EIENVKSELKELEARIEELEEDLHKLEEALNDLEARL-SHSRIPEIQAELSKLEEE 806
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    496 IKELQDKLADVNKELSHLHTkcadREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQ 575
Cdd:TIGR02169  807 VSRIEARLREIEQKLNRLTL----EKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLES 882
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    576 HLVAgcvlikqpegmldkfswselcavLQENVDALIADLNRANEKIRHLEYicknKSDTMRELQQTQEDTFTKVAEQIKA 655
Cdd:TIGR02169  883 RLGD-----------------------LKKERDELEAQLRELERKIEELEA----QIEKKRKRLSELKAKLEALEEELSE 935
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    656 QESCWHRQKK--ELELQYSELFLEVQKRAQKFQEIAEKNM----------EKLNHIEKSHEQLVLENSHFKKLLSQTQRE 723
Cdd:TIGR02169  936 IEDPKGEDEEipEEELSLEDVQAELQRVEEEIRALEPVNMlaiqeyeevlKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
PRK12704 PRK12704
phosphodiesterase; Provisional
97-294 8.12e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    97 LGRRAAEERLAEAHRIQEKLcAQNSELQAKTNETEKAFQtSQQKWKEECRRFEHDLEERDNMIQncnreydllmkeksRL 176
Cdd:PRK12704   24 VRKKIAEAKIKEAEEEAKRI-LEEAKKEAEAIKKEALLE-AKEEIHKLRNEFEKELRERRNELQ--------------KL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   177 EKTLQealekhQREKNeMESHIRETALEEFRLQEEQWEAERRELQfivqeqdtaVQNMHKKVEKLETEHMDcsdllrrqt 256
Cdd:PRK12704   88 EKRLL------QKEEN-LDRKLELLEKREEELEKKEKELEQKQQE---------LEKKEEELEELIEEQLQ--------- 142
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 38348729   257 sELEfstqREERLRKEfEATTLRVRKLEENIEAERAAH 294
Cdd:PRK12704  143 -ELE----RISGLTAE-EAKEILLEKVEEEARHEAAVL 174
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
51-289 8.36e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.54  E-value: 8.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729     51 EITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDlavaRKEAGLGRRAAEERLAEAHRIQEKLCAQNSELQAKTNET 130
Cdd:pfam01576  349 EMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESE----NAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSES 424
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    131 EKAfqtsQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTL---QEALEKHQREKNEMESHIRetaleefr 207
Cdd:pfam01576  425 ERQ----RAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLqdtQELLQEETRQKLNLSTRLR-------- 492
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    208 lqeeQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRvrkLEENI 287
Cdd:pfam01576  493 ----QLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQ---LEEKA 565

                   ..
gi 38348729    288 EA 289
Cdd:pfam01576  566 AA 567
46 PHA02562
endonuclease subunit; Provisional
346-565 8.50e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.38  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   346 EKHNAQEsfaKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCSELQEELVmakkhqaflvetceNNVKELE 425
Cdd:PHA02562  189 KIDHIQQ---QIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELL--------------NLVMDIE 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   426 SILDSFtvsGQWTSGIHKDKDKPPSFSVVLERLR---------RTLTDYQNKLEDASNEEKACN-ELDstkqKIDSHTKN 495
Cdd:PHA02562  252 DPSAAL---NKLNTAAAKIKSKIEQFQKVIKMYEkggvcptctQQISEGPDRITKIKDKLKELQhSLE----KLDTAIDE 324
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729   496 IKELQDKLADVNKELSHLHTKcadrealISTLKVELQNvlhcwekEKAQAAQSESELQKLSQAFHKDAEE 565
Cdd:PHA02562  325 LEEIMDEFNEQSKKLLELKNK-------ISTNKQSLIT-------LVDKAKKVKAAIEELQAEFVDNAEE 380
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
121-341 8.81e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.49  E-value: 8.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    121 SELQAKTNETEKAFQTSQQKWKEECRRFEHdLEERDNMIQNCNREydllMKEKSRLEKTLQEALEKHQREKNEMESHIRE 200
Cdd:pfam05557   30 IELEKKASALKRQLDRESDRNQELQKRIRL-LEKREAEAEEALRE----QAELNRLKKKYLEALNKKLNEKESQLADARE 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    201 TALE-EFRLQEEQWEAERRELQFIVQ------------EQDTAVQNMHKKVEKLETEHMDCSDlLRRQTSELEFSTQREE 267
Cdd:pfam05557  105 VISClKNELSELRRQIQRAELELQSTnseleelqerldLLKAKASEAEQLRQNLEKQQSSLAE-AEQRIKELEFEIQSQE 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348729    268 R---LRKEFEATTLRVRKLEENIEA--ERAAHL-ESKFNSEIIQLRIRDLEGALQVEKASQAEAVA---DLEIIKNEFKE 338
Cdd:pfam05557  184 QdseIVKNSKSELARIPELEKELERlrEHNKHLnENIENKLLLKEEVEDLKRKLEREEKYREEAATlelEKEKLEQELQS 263

                   ...
gi 38348729    339 VES 341
Cdd:pfam05557  264 WVK 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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