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Conserved domains on  [gi|229093316|ref|NP_775813|]
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putative phospholipase B-like 2 isoform 1 precursor [Homo sapiens]

Protein Classification

phospholipase B family protein( domain architecture ID 10522720)

phospholipase B family protein may catalyze the hydrolytic cleavage of acylester bonds in glycerophospholipids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-584 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


:

Pssm-ID: 461479  Cd Length: 483  Bit Score: 593.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNST---EFCdPKLRAFLEENL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPgSRVL 398
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELP-DGTF 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  399 TILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRL 478
Cdd:pfam04916 310 WVVEQIPGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKAL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  479 MRYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVP 558
Cdd:pfam04916 390 MRYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQP 454
                         490       500
                  ....*....|....*....|....*..
gi 229093316  559 PFQWSTSP-FSGLLHMGQPDLWKFAPV 584
Cdd:pfam04916 455 PFDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-584 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 461479  Cd Length: 483  Bit Score: 593.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNST---EFCdPKLRAFLEENL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPgSRVL 398
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELP-DGTF 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  399 TILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRL 478
Cdd:pfam04916 310 WVVEQIPGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKAL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  479 MRYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVP 558
Cdd:pfam04916 390 MRYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQP 454
                         490       500
                  ....*....|....*....|....*..
gi 229093316  559 PFQWSTSP-FSGLLHMGQPDLWKFAPV 584
Cdd:pfam04916 455 PFDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-584 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 461479  Cd Length: 483  Bit Score: 593.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYC-ERLKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNST---EFCdPKLRAFLEENL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPgSRVL 398
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELP-DGTF 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  399 TILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRL 478
Cdd:pfam04916 310 WVVEQIPGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKAL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229093316  479 MRYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVP 558
Cdd:pfam04916 390 MRYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQP 454
                         490       500
                  ....*....|....*....|....*..
gi 229093316  559 PFQWSTSP-FSGLLHMGQPDLWKFAPV 584
Cdd:pfam04916 455 PFDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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