|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-478 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 671.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 42 LAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYKWDAETQGWILGSFFYGYIV 121
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 122 TQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTI 201
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 202 SYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvp 281
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 282 wgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTI 361
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 362 SVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGP 441
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 27370146 442 IIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-478 |
5.31e-178 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 504.85 E-value: 5.31e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 43 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKecaehsapIKVHHNHTGKKYKWDAETQGWILGSFFYGYIVT 122
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST--------DKDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 123 QIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 202
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvpw 282
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 283 gsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTIS 362
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 363 VRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPI 442
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 27370146 443 IAKSLTPDN-TIREWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17318 353 IVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-478 |
7.85e-122 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 361.27 E-value: 7.85e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 43 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEhsapikvhhnhtgkkYKWDAETQGWILGSFFYGYIVT 122
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAE---------------FNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 123 QIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 202
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 203 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIvsdtpethktishyekeyivsslknqlssqkvvpw 282
Cdd:cd17382 146 FCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 283 gsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTIS 362
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 363 VRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPI 442
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
410 420 430
....*....|....*....|....*....|....*.
gi 27370146 443 IAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17382 345 IVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-491 |
5.20e-117 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 352.12 E-value: 5.20e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 30 EAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSnttltDNRTSKECAEHSAPIKVHHNhtgKKYKWDAETQG 109
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 110 WILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 190 APPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVS 268
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 269 SLKNQ-LSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 347
Cdd:TIGR00894 240 SLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 348 AADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLG 427
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27370146 428 ITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHH 491
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-478 |
1.03e-104 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 316.80 E-value: 1.03e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 44 ILAFCGFFVLYALRVNLSVALVDMvdsnttltdnrtSKEcaehsapikvhhnhtgkkYKWDAETQGWILGSFFYGYIVTQ 123
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPM------------AKE------------------FGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 124 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 203
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 204 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSdtpethktishyekeyivsslknqlssqkvvpwg 283
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 284 silkslPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwNFSTISV 363
Cdd:cd17380 178 ------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 364 RRIFSLVGMVGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPII 443
Cdd:cd17380 250 RKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328
|
410 420 430
....*....|....*....|....*....|....*
gi 27370146 444 AKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17380 329 TGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-472 |
2.99e-46 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 164.67 E-value: 2.99e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 39 RYNLAILAFCGFFVLYALRVNLSVALVDMvdsnttltdnrtskecaehsapikvhhnhtGKKYKWDAETQGWILGSFFYG 118
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 119 YIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 199 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDtpethktishyekeyivsslknqlssqk 278
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 279 vvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnf 358
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 359 stisVRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAP-SYAGILLGITNTFATIPG 437
Cdd:cd17319 246 ----ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGG 320
|
410 420 430
....*....|....*....|....*....|....*
gi 27370146 438 MTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAI 472
Cdd:cd17319 321 FVAPLLIGYLV--DATGSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-479 |
3.83e-40 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 148.48 E-value: 3.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 39 RYNLAILAFCGFFVLYALRVNLSVALVDMVDSnttltdnrtskecaehsapikvhhnhtgkkYKWDAETQGWILGSFFYG 118
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 119 YIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 199 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIlwmwivsdtpethktishyekeyivsslknqlssqk 278
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 279 vvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLrvkwnf 358
Cdd:COG2271 180 ----------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL------ 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 359 stISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGM 438
Cdd:COG2271 244 --GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 27370146 439 TGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFAK 479
Cdd:COG2271 322 LGPLLVGYLL---DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-474 |
2.20e-38 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 144.11 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 101 YKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFP 180
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--LLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 181 AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYY--MNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKti 258
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 259 shyekeyivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 338
Cdd:cd06174 182 ---------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 339 WLCMILCGQAADYLRvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIA 418
Cdd:cd06174 253 ALGSLLLGLLSDRLI---------GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 27370146 419 PSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIreWQTVFCIAAAINVFGAIFF 474
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-441 |
2.04e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 123.68 E-value: 2.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 98 GKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGV 177
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 178 TFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILwmWIVSDTPETHKT 257
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 258 ISHYEKEYIVSslknqlssqkVVPWGSILKSLPLWAIVVAhFSYNWSFYTLLTLLPTYMkEILRFNVQENGFLSALPYFG 337
Cdd:pfam07690 180 PKPAEEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 338 CWLCMILCGQAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDI 417
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 27370146 418 APSYAGILLGITNTFATIPGMTGP 441
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-478 |
3.63e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.59 E-value: 3.63e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivs 268
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 269 slKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 348
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 349 ADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 27370146 429 TNTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFA 478
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
99-477 |
3.98e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.89 E-value: 3.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 99 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVT 178
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEthkti 258
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 259 shyekeyivssLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 338
Cdd:COG2223 186 -----------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 339 WLCMILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLA-VAFLTISTTLGGFASSGFSINHLDI 417
Cdd:COG2223 255 ALGRPLGGWLSDRIG----------GRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 418 APSYAGILLGITNTFATIPGMTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
103-435 |
2.14e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.20 E-value: 2.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 103 WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAM 182
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 183 HAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV-WFILWMWIVSDTPETHKTISHy 261
Cdd:COG2814 120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARARLRG- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 262 ekeyivsslknqlssqkvvPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 341
Cdd:COG2814 199 -------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 342 MILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 421
Cdd:COG2814 260 ALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....
gi 27370146 422 AGILLGITNTFATI 435
Cdd:COG2814 330 RGRASGLYNSAFFL 343
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-446 |
9.42e-16 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 79.22 E-value: 9.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 110 WILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG--GLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 190 APPLERSKLLTISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS 259
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 260 HYEKEYIVSSLK-NQ--LSSQKVVP--WGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALP 334
Cdd:cd17327 199 EEEKELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 335 YFGCwLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVflvaagFIGCDYSLAVAFLTISTTLGGFASSGFSINH 414
Cdd:cd17327 279 ALGA-VSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII------LLAAPNPPGAYFAAYILGGGSYAGFPILLSW 346
|
330 340 350
....*....|....*....|....*....|....*
gi 27370146 415 L-DIAPSYAG--ILLGITNTFATIPGMTGPIIAKS 446
Cdd:cd17327 347 IsSNCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
95-447 |
6.43e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 76.24 E-value: 6.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 95 NHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLG 174
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 175 EGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWM--------W 246
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 247 IVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVP--WGSILK----------SLPLWaivVAHFSYNWSFYTLLTLLPT 314
Cdd:TIGR00895 199 LVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 315 YMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisVRRIFSLVGmvgpAVFLVAAGFigcDYSLAVA 394
Cdd:TIGR00895 276 LMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-------VTALLLLLG----AVFAVLVGS---TLFSPTL 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27370146 395 FLTISTTLGGFASSGFSINHLDIAPSYA--------GILLGITNTFATIpgmtGPIIAKSL 447
Cdd:TIGR00895 341 LLLLGAIAGFFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGAII----GPILAGYL 397
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
109-443 |
1.25e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 75.49 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFtpLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGI-ICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS-----HYE 262
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 263 KEYIVSSLKNQLSSQKVVPWgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 342
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQ-YVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 343 ILCGQAADYLrvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF----SINHLDIA 418
Cdd:TIGR00881 270 LLAGWLSDKL----------FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELA 339
|
330 340
....*....|....*....|....*.
gi 27370146 419 PSYA-GILLGITNTFATIPGMTGPII 443
Cdd:TIGR00881 340 PKKAaGTAAGFVGFFAYLGGILAGLP 365
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-477 |
5.36e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 5.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLgvVTLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--ALLLAGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivs 268
Cdd:cd17474 115 LFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 269 slKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGcwlcmilcGQA 348
Cdd:cd17474 180 --AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL--------LAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 349 ADYLRVKWNFSTISVRRIFsLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLG 427
Cdd:cd17474 250 GSLFVGRLLKKRFGARRIL-VIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 27370146 428 ITNTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
163-428 |
3.69e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.44 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 163 TLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYyMNWTYVFYLFGiVGIVWFI 242
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 243 LWMWIVSDTPETHKTISHYEKEyivsslknqlsSQKVVPWGSIlkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRF 322
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 323 NVQENGFLSAlpyfgcwlcmilcgqaadylrvkwnfstisvrrIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTL 402
Cdd:cd17473 231 SAALIGLALA---------------------------------IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260
....*....|....*....|....*.
gi 27370146 403 GGFAssgfsinhldIAPSYAGILLGI 428
Cdd:cd17473 278 LLLA----------LASGLWVVLLGA 293
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-475 |
8.93e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 8.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivs 268
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 269 slknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 348
Cdd:cd17324 184 ------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 349 ADylrvkwnfsTISVRRIFSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 428
Cdd:cd17324 258 AD---------RGGRRALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 27370146 429 TNTFATIPGMTGPIIAkSLTPDNTirEWQTVFCIAAAINVFGAIFFT 475
Cdd:cd17324 327 YLAAYNLGGALGAALG-GLVLDHG--GWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-243 |
4.67e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.51 E-value: 4.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 104 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAadLGVVTLVVLRALEGLGEGVTFPAMH 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL 243
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
194-477 |
8.17e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 8.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 194 ERSKLLTISYAGAQLGTVISLPLSGIICYYM------NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKtishyEKEYIV 267
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 268 SSLKnqlssqkvvpwgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 347
Cdd:COG2211 219 ESLK------------ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 348 AADYlrvkwnfstISVRRIFsLVGMVGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFASSGFSINHL----DIAP---- 419
Cdd:COG2211 287 LAKR---------FGKKKAF-IIGLLLAALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydew 353
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27370146 420 ----SYAGILLGITNTFATIPGMTGPII-----------AKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2211 354 ktgrRREGLYFGIFTFAIKLGQALAGALaglllalfgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
124-474 |
2.42e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.69 E-value: 2.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 124 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 203
Cdd:cd17371 52 ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 204 AGAQLG----TVISLPLSGIICYYMNWTYVFYLfgivGIVWFILWMWIVSDTPEThktishyeKEYIVSSLKNQLSSQKV 279
Cdd:cd17371 130 SGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL----GALPALLVLFIRRFVKEP--------PQWQAARAARRHFADRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 280 VPWG---SILKSLPLWAIVVAHFSYnWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKW 356
Cdd:cd17371 198 SLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 357 NFstisvrRIFSLVGmvgpAVFLVAAGFIGCDYSLavaFLTISTTLGGFASSGFSINHLDIAPSYA----GILLGITNTF 432
Cdd:cd17371 277 NF------ALFALGS----AISILLYFFLPLSPTL---ILILGFPLGFFASGPFSGMGAYLTELFPtavrATAQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 27370146 433 ATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFF 474
Cdd:cd17371 344 GRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
96-443 |
3.76e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 96 HTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGE 175
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 176 GVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETH 255
Cdd:cd17329 103 GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 256 ktishyekeyivsslKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPy 335
Cdd:cd17329 182 ---------------RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 336 fgcwLCMILCGQaadYLRVKWnFSTISVRRIFsLVGMVGPAVFLVAAGFIGCDYSL--AVAFLTISTTLGGFASSGFsIN 413
Cdd:cd17329 246 ----ALLIVLLQ---FPVARL-VERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLilAMIVLTLGEMLVFPAVQTL-VA 315
|
330 340 350
....*....|....*....|....*....|
gi 27370146 414 HLdIAPSYAGILLGITNTFATIPGMTGPII 443
Cdd:cd17329 316 AL-APPDKRGSYMGFYALAWGLGRAIGPLV 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-443 |
4.48e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.86 E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLglgilgtSVFTLFTPLAADL-----GVVTLVVLRALEGLGEGVTFPAMH 183
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVL-------AVGLLLMGAAALLmalvgSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL-WMWIvsdtpethktishye 262
Cdd:cd17475 107 RAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFY--------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 263 KEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 342
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 343 ILCGQAADYLRVKwnfstisvRRIFSLVGMVGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF-SINHLDIA--- 418
Cdd:cd17475 252 IGLGRVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesa 322
|
330 340
....*....|....*....|....*.
gi 27370146 419 -PSYAGILLGITNTFATIPGMTGPII 443
Cdd:cd17475 323 gPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-443 |
7.66e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 7.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMwSS 188
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMN----WTYVFYLFGIVGIVWFILWMWivSDTPETHKTISHyeke 264
Cdd:COG0738 123 ALGPETAASRLNLLHAFFSLGALLG-PLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEE---- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 265 yivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQEngflSALPYFGCWLCMIL 344
Cdd:COG0738 196 ----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAT----AALGLSLFWGGMTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 345 CGQAADYLRVKWNFSTisVRRIFSLVGMVGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFASSGFS-INHL--DIAPSY 421
Cdd:COG0738 262 GRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKR 331
|
330 340
....*....|....*....|..
gi 27370146 422 AGILLGITNTFATIPGMTGPII 443
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPL 353
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
160-484 |
1.07e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.64 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 160 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPpLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 239
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 240 WFILWMWIVSDTPETHKtishyekeyivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEi 319
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 320 LRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVFLVAAGFigcdySLAVAFLTIS 399
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL-----LLGLLGLAGLLGLLLAPGS-----LPWLWAVLLG 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 400 TTLGGFASSGFS-INHLDIAPSYAGILLGITNTFATIPGMTGPIIA---KSLTPDntireWQTVFCIAAAINVFGAIFFT 475
Cdd:COG2807 315 LGQGGLFPLALTlIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVgalHDATGS-----WTAALLLLAALAVLMLVAGL 389
|
....*....
gi 27370146 476 LFAKGEVQS 484
Cdd:COG2807 390 LAGRPYVED 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
294-477 |
1.08e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 294 IVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 373
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTpdnTI 453
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 27370146 454 REWQTVFCIAAAINVFGAIFFTLF 477
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-398 |
1.29e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.70 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 107 TQGWILGSFF-YGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 186 WSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKE 264
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 265 YIVSSLKNqlssqkvvpWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAlpYFGCWLCM-- 342
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 343 ----ILCGQAADYLRVKwnfsTISVRRIFSLVGMVGPAVFLVAAgFIGCDYSLAVAFLTI 398
Cdd:cd17328 261 vlgvLLGGILADRLRRK----TPRADPLVCAVGLLAAAPFLFLA-LVLALSNLLLAWVLL 315
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
148-243 |
1.48e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 50.27 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 148 VFTLFTPLAA---DLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM 224
Cdd:cd17503 70 LFTLGSLLCGlapNLAS--LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL 147
|
90
....*....|....*....
gi 27370146 225 NWTYVFYLFGIVGIVWFIL 243
Cdd:cd17503 148 SWRWIFYINLPIGILALLL 166
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
109-477 |
2.08e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.93 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLF--TPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMW 186
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 187 SSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM---NWTYVFYLFGIVGIVWFILWMWIVSDTPET------HKT 257
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESeglppiEEY 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 258 ISHYEKEYIVSSLKNQLSSQKVVpWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFG 337
Cdd:cd17345 201 KGDYPEEADGEEEEQELSAWEIF-VKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 338 CWLCMILCGQAADYLrvkwnfstISVRRifSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSG----FSIN 413
Cdd:cd17345 280 AIPGTLLAGWLSDKL--------FKGRR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQ 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27370146 414 HLDIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQTVFcIAAAINVFGAIFFTLF 477
Cdd:cd17345 348 ALELVPKKAaGTAAGLTGLFGYLGGSVLATALIGIIVDHF--GWNGGF-IVLLASCILAIIFLAL 409
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-248 |
2.35e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.50 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 99 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVT 178
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIV 248
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
109-477 |
4.10e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.81 E-value: 4.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF--FAVLWGLNGLFQSMGWPPCVKLLGN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivs 268
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 269 slknqlssqkvvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 348
Cdd:cd17312 185 ----------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 349 ADYLrvkWNFSTISVRRIFSLVGMVGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLG 427
Cdd:cd17312 243 SDKL---FGGRRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATG 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 27370146 428 ITNTFATIPGMTGPIIAKSLTPDNTireWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd17312 317 FVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-477 |
4.51e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVT---LVVLRALEGLGEGVTFPAMHAM 185
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 186 WSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekey 265
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA----------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 266 ivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYT-LLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIL 344
Cdd:cd06173 186 --PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 345 CGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGI 424
Cdd:cd06173 264 LGRLSKRRR----------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 27370146 425 LLGITNTFATIPGMTGPIIAKSLTPDNTIRewqTVFCIAAAINVFGAIFFTLF 477
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLS---AVFLLAGALLLLAALLLLLL 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
99-253 |
1.38e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 99 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVT 178
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27370146 179 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPE 253
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-443 |
1.49e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 104 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLgvVTLVVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM----NWTYVFYLFGIVGIVWFILWMWIvsdtpethktis 259
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLLRRRT------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 260 hyekeyivsslknqlssqkvvpwgsilkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 339
Cdd:cd17316 180 --------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 340 LCMILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTIstTLGGFASSGFSINHLDIAP 419
Cdd:cd17316 228 VGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAE 295
|
330 340
....*....|....*....|....*...
gi 27370146 420 SYA----GILLGITNTFATIPGMTGPII 443
Cdd:cd17316 296 LFPtevrATGVGLSYNLGRLGGGGAPPL 323
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
109-252 |
2.44e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP--SLLVARLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTP 252
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESR 194
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
149-252 |
2.86e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.10 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 149 FTLFTPLAA-DLGVVTLVVLRALEGLGEGVTFP-AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 226
Cdd:cd17476 73 FAIWSLIAGfSPNFIFFIICRALQGLGPAFLLPnAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWW 152
|
90 100
....*....|....*....|....*..
gi 27370146 227 TYVFYLFGIVGIVWFIL-WMWIVSDTP 252
Cdd:cd17476 153 PWIFWFLAILAAIVAVAaIFWTSPSFI 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-243 |
2.93e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.04 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 104 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMH 183
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 184 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL 243
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
160-473 |
6.97e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 6.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 160 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 239
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 240 WFILwmwivsdtpethktishyekeyivsslknqlssqkvvpwgsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEI 319
Cdd:cd17321 163 ALLL--------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 320 LRFNVQENGFLSaLPYFgcwLCMILCGQAADYLRVKWNFstisvrRIFSLVGMVGPAVFLVAAGFIGCDYS---LAVAFL 396
Cdd:cd17321 199 LGYSPLQAGLAL-LPLA---LAMLVAAPLAGRLADRFGP------RLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 397 TISTTLGGFASSGFSINHLDIAPSYAGILLGITNT--------------------FATIPGMTGPIIAKSLTPDNTIREW 456
Cdd:cd17321 269 LLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTarqlggalgvallgalltagLSANLGDSGVAALLSAAAAAFAAGF 348
|
330
....*....|....*..
gi 27370146 457 QTVFCIAAAINVFGAIF 473
Cdd:cd17321 349 HLAFLVAAALALLAALL 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-476 |
2.62e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.08 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAM----HA 184
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL--FVVLMFLAGLGAGILDTGAntfvGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 185 MWSSwapplERSKLLTISYAGAQLGTVISLPLSG-IICYYMNWTYVFYLFGIVGIVWFILWMWIVSdtPETHKTishyek 263
Cdd:cd17333 112 LFEE-----SSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLF--PELPSA------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 264 eyivsSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAlpyfGCWLCMI 343
Cdd:cd17333 179 -----RNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS----GFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 344 LCgqaadylrvKWNFSTISVRrifslvgmVGPAVFLVAAGFIGCDYSLAVAFLT------ISTTLGGFASSG----FSIN 413
Cdd:cd17333 250 IG---------RLLGGPISRR--------IKPHTLLVLSGSGALLGLLILLLAPtlvvglVATALLGLFMAAlfptILSL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27370146 414 HLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIrewQTVFCIaaaINVFGAIFFTL 476
Cdd:cd17333 313 GISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGI---QTAMLL---ITILYAIIFVL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
121-445 |
4.33e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 121 VTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVlrALEGLGEGVTFPAMHAMWSSWAPPlERSKLLT 200
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGIGSAAFHPEGARLASQAAGG-RRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 201 ISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIshyekeyivsslKNQLSSQKVV 280
Cdd:cd17478 123 IFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK------------AAAKSSARST 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 281 PWGSILKSLPLWAIVvahFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALpYFGCWLCMILCGQAADYlrvkwnfst 360
Cdd:cd17478 190 LKGVWRALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGAIGTLIGGPLSDR--------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 361 ISVRRIFsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFASSGFSINHL---DIAPSYAGILLGITNTFA-TIP 436
Cdd:cd17478 257 FGRRRVI-IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLG 330
|
....*....
gi 27370146 437 GMTGPIIAK 445
Cdd:cd17478 331 GIGAPVLGA 339
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
163-474 |
4.47e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.62 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 163 TLVVLRALEGLGeGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVIS----LPLSGIICY---YMNWTYVFYLFGI 235
Cdd:cd17341 90 GLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 236 VGIVWFILwMWIVSDTPETHKtishyekEYIVSSLKNQLSsqkvvpwgsILKSLPLWAIVVAHFSYNWSFYTLLTLLPTY 315
Cdd:cd17341 169 LLAIAAVL-VLLFGDDLPTGK-------ASALEFLKVQLA---------VLKNYRTWILSLLYGVTFGSFVGFSNVLPTY 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 316 MKEILRFNVQENGFLSALPYFGCWLCMILCGQAADylrvKWNFStisVRRIFSLVGMVGPAVFLVAAGFIgcDYSLAVAF 395
Cdd:cd17341 232 FKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGR---RRLWWLFIVMTIGAALLSLSLPT--SGTNLVLF 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 396 LTISTTLGGFASSGF-SINHL--DIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAI 472
Cdd:cd17341 303 LALFVALGLGAGAGNgSVFRMvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
..
gi 27370146 473 FF 474
Cdd:cd17341 383 WL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
287-477 |
8.53e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 287 KSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADylrvkwnfsTISVRRI 366
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 367 FsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKS 446
Cdd:COG2814 78 L-LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|.
gi 27370146 447 LTpdnTIREWQTVFCIAAAINVFGAIFFTLF 477
Cdd:COG2814 157 LA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
294-477 |
1.19e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 294 IVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 373
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 374 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAkSLTPDNTI 453
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 27370146 454 REWQTVFCIAAAINVFGAIFFTLF 477
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
109-477 |
2.24e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 109 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 189 WAPPLERSKLLTISYAGAQLGTVISLPLSGIIcyYMNWTY--VFYLFGIVGIVWFILwMWIVSDTPETHKTISHYEKeyi 266
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFL--YQHLGFavLFIVAAVLALLALLL-VFLVKDPPPVAAEEAEAGT--- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 267 vsSLKNQLSSQKVVPWGSILkslplwaiVVAHFSYNwsfyTLLTLLPTYMKEILRFNVqenGFLSALPYFGCWLCMILCG 346
Cdd:cd17489 186 --RAFRRLVEKKVLPPALIL--------FLASIAYG----AISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 347 QAADYLRVKWnfsTISVRRIFSLVGMV------GPAVFLVAAGFIGCDYSLAVAFLTIST------TLGGFASSGFSINh 414
Cdd:cd17489 249 KLSDRKGPKT---VIIPGLLLLALGLLllsfagSPWMLLLAAVLYGLGFGLLFPALQALAvdlvppHRRGAANGTFFIF- 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27370146 415 LDIAPSYAGILLGITNTFATIPGMtgpiiaksltpdntirewqtvFCIAAAINVFGAIFFTLF 477
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFGYRAM---------------------FLLAAVVVLLALVLYIFL 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
102-247 |
2.37e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 102 KWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPA 181
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL--LLAALFLLGLAGGLFNVP 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27370146 182 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWI 247
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
103-340 |
5.24e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 103 WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAadLGVVTLVVLRALEGLGEGVTFPAM 182
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALT--SGFAALLALRFLAGAASAFVFVFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 183 HAMWSSWAPPLERSKLLTISYAGAQLGTVIS-LPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIShy 261
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 262 ekeyivsslknqlSSQKVVPWGsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAL---PYFGC 338
Cdd:cd06180 187 -------------AAESAPGLN-----RPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFglaAVPSC 248
|
..
gi 27370146 339 WL 340
Cdd:cd06180 249 FL 250
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
155-248 |
6.75e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 155 LAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFG 234
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
90
....*....|....
gi 27370146 235 IVGIVWFILWMWIV 248
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-209 |
8.74e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 8.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370146 100 KYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLgvVTLVVLRALEGLGEGVTF 179
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL--WLLLLALFLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|
gi 27370146 180 PAMHAMWSSWAPPLERSKLLTISYAGAQLG 209
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
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