NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1376476223|ref|NP_742164|]
View 

sodium/potassium/calcium exchanger 4 isoform 1 precursor [Mus musculus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 2.83e-120

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 382.81  E-value: 2.83e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSNELEDGnDLYDGSYDDPS-----------VPLLG------------- 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKVMALG-DLSKGDVAEAEhtgertgeegeRPTEAegengeesggeae 668

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  293 -------------------------------QVKEKPPYGKTPVVMVDEILSSSP--------------------PKFTF 321
Cdd:TIGR00927  669 qegetetkgenesegeipaerkgeqegegeiEAKEADHKGETEAEEVEHEGETEAegtedegeietgeegeevedEGEGE 748

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  322 PEAGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPP 396
Cdd:TIGR00927  749 AEGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEV 828

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  397 PQPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKW 427
Cdd:TIGR00927  829 KDETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIY 908

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  428 VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASL 507
Cdd:TIGR00927  909 LFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSV 988

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  508 IVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKL 587
Cdd:TIGR00927  989 IVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKIL 1067

                          650
                   ....*....|....*....
gi 1376476223  588 GIYVLVLYAVFLCFSIMIE 606
Cdd:TIGR00927 1068 GFTMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 2.83e-120

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 382.81  E-value: 2.83e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSNELEDGnDLYDGSYDDPS-----------VPLLG------------- 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKVMALG-DLSKGDVAEAEhtgertgeegeRPTEAegengeesggeae 668

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  293 -------------------------------QVKEKPPYGKTPVVMVDEILSSSP--------------------PKFTF 321
Cdd:TIGR00927  669 qegetetkgenesegeipaerkgeqegegeiEAKEADHKGETEAEEVEHEGETEAegtedegeietgeegeevedEGEGE 748

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  322 PEAGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPP 396
Cdd:TIGR00927  749 AEGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEV 828

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  397 PQPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKW 427
Cdd:TIGR00927  829 KDETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIY 908

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  428 VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASL 507
Cdd:TIGR00927  909 LFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSV 988

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  508 IVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKL 587
Cdd:TIGR00927  989 IVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKIL 1067

                          650
                   ....*....|....*....
gi 1376476223  588 GIYVLVLYAVFLCFSIMIE 606
Cdd:TIGR00927 1068 GFTMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-601 2.90e-35

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 134.88  E-value: 2.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 120 DFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 200 WWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMkynmkmqtffttkqksiangnpvsneledgndly 279
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 280 dgsyddpsvpllgqvkekppygktpvvmvdeilsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsan 359
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 360 gvnskpLQNGRHENMENGNVPVENPEDPQqgqeqqpppqppppepesvetvflspfsmpeakgdkakwvfTWPLIFLLcv 439
Cdd:COG0530   126 ------IRRARKEPAWEEVEEELEEKPKM-----------------------------------------SLWKALLL-- 156

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 440 tipncskprwekffmvtFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAV 519
Cdd:COG0530   157 -----------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAV 219

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 520 SNTIGSNVFDILVGLGIPwglqtMVInygSTVKINSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGIYVLVLYAVFL 599
Cdd:COG0530   220 GNIIGSNIFNILLVLGIG-----ALI---TPIPVDPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYL 290


                  ..
gi 1376476223 600 CF 601
Cdd:COG0530   291 AL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 452-604 3.09e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 104.61  E-value: 3.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 452 FFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 531
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376476223 532 VGLGIPWGLqTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGIYVLVLYAVFLCFSIM 604
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 476-599 1.80e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 62.74  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 476 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKIns 555
Cdd:PRK10734  198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLAFSRD-- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1376476223 556 rglvYSVVLLLgSVALTVLGIhLNKWRLDRKLGIYVLVLYAVFL 599
Cdd:PRK10734  276 ----YWVMLLV-SVIFALLCW-RRKRRIGRGAGALLLGGFIVWL 313
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 2.83e-120

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 382.81  E-value: 2.83e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223   80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  237 LYVFYILIMKYNMKMQTFFttkqKSIANGNPVSNELEDGnDLYDGSYDDPS-----------VPLLG------------- 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIELWV----KEQLSRRPVAKVMALG-DLSKGDVAEAEhtgertgeegeRPTEAegengeesggeae 668

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  293 -------------------------------QVKEKPPYGKTPVVMVDEILSSSP--------------------PKFTF 321
Cdd:TIGR00927  669 qegetetkgenesegeipaerkgeqegegeiEAKEADHKGETEAEEVEHEGETEAegtedegeietgeegeevedEGEGE 748

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  322 PEAGLRIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVNSK----PLQNGRHENMENGNVPVENPEDPQQGQEQQPP 396
Cdd:TIGR00927  749 AEGKHEVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEV 828

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  397 PQPPPPEPESV-----------------------------------------------ETVFLSPFSM--PEAKGDKAKW 427
Cdd:TIGR00927  829 KDETGEQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIY 908

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  428 VFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASL 507
Cdd:TIGR00927  909 LFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSV 988

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  508 IVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKL 587
Cdd:TIGR00927  989 IVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKIL 1067

                          650
                   ....*....|....*....
gi 1376476223  588 GIYVLVLYAVFLCFSIMIE 606
Cdd:TIGR00927 1068 GFTMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 102-598 1.15e-42

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 155.94  E-value: 1.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 102 LHILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 181
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 182 LCIIGVCGLFAgQVVRLTWWaVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILimkynmkmqtFFTTKQKS 261
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLL----------FLVKNERW 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 262 IANgnpvSNELEDGNDlydgsyddpsvpllgqvkekppygktpvvmvdeilsssppkftfpeaglrimitnkfgprtrlr 341
Cdd:TIGR00367 149 VKY----DTYTEENLD---------------------------------------------------------------- 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 342 masriiinerqrlinsangvnskplqngrhenmengnvpvENPEDpqqgqeqqpppqppppepesvetvflspfsmpeak 421
Cdd:TIGR00367 161 ----------------------------------------ENNRR----------------------------------- 165

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 422 gdkakwvftwPLIFllcvtipncskprwekFFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVP 501
Cdd:TIGR00367 166 ----------PQIF----------------FSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLP 219

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 502 DCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMvinygsTVKINSRGLVYSVVLLlgsVALTVLGIHLNKW 581
Cdd:TIGR00367 220 ELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPI------PVEPLAYNLDAPVMVI---VTLLLMLFFKTSM 290

                         490
                  ....*....|....*..
gi 1376476223 582 RLDRKLGIYVLVLYAVF 598
Cdd:TIGR00367 291 KLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-601 2.90e-35

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 134.88  E-value: 2.90e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 120 DFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 200 WWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMkynmkmqtffttkqksiangnpvsneledgndly 279
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 280 dgsyddpsvpllgqvkekppygktpvvmvdeilsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsan 359
Cdd:COG0530       --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 360 gvnskpLQNGRHENMENGNVPVENPEDPQqgqeqqpppqppppepesvetvflspfsmpeakgdkakwvfTWPLIFLLcv 439
Cdd:COG0530   126 ------IRRARKEPAWEEVEEELEEKPKM-----------------------------------------SLWKALLL-- 156

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 440 tipncskprwekffmvtFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAV 519
Cdd:COG0530   157 -----------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAV 219

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 520 SNTIGSNVFDILVGLGIPwglqtMVInygSTVKINSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGIYVLVLYAVFL 599
Cdd:COG0530   220 GNIIGSNIFNILLVLGIG-----ALI---TPIPVDPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYL 290


                  ..
gi 1376476223 600 CF 601
Cdd:COG0530   291 AL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 452-604 3.09e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 104.61  E-value: 3.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 452 FFMVTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 531
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1376476223 532 VGLGIPWGLqTMVINYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGIYVLVLYAVFLCFSIM 604
Cdd:pfam01699  81 LVLGLSALI-GPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 6.17e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.84  E-value: 6.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 103 HILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1376476223 183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-245 1.13e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 95.59  E-value: 1.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  79 DPAIHEFPTDLFSNKERQHGAVLLHILGALymfyALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASV 158
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 159 IGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG-----QVVRLTWWAVcrdsvyyTLSVIVLIAFIY-DEEIVWWEGL 232
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPipvdpAVLSFDLPVM-------LAATLLLLGLLRtGGRIGRWEGL 280

                         170
                  ....*....|...
gi 1376476223 233 VLIILYVFYILIM 245
Cdd:COG0530   281 LLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
482-606 3.41e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 73.63  E-value: 3.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 482 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIpwglqTMVInygSTVKINSRGLVYS 561
Cdd:COG0530    15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGL-----AALI---RPLAVDRRVLRRD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1376476223 562 VVLLLGSVALTVLGIHLNkwRLDRKLGIYVLVLYAVFLCFSIMIE 606
Cdd:COG0530    87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 108-238 2.19e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.21  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 108 LYMFYALAIVCDDFfVPSLEKICEK---------------LHL---SEDVAGATFMAAGSSTPELFASVIGVF---ITHG 166
Cdd:TIGR00845  83 VYMFLGVSIIADRF-MASIEVITSQekeitikkpngettvTTVriwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 167 DVGVGTIVGSAVFNILCIIGVCGLF--AGQVVRL----------TWwavcrdSVYYTLSVIVLIAFIYDEEIVWWEGLVL 234
Cdd:TIGR00845 162 DLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtaAW------SVFAYVWLYLILAVFSPGVVEVWEGLLT 235


                  ....
gi 1376476223 235 IILY 238
Cdd:TIGR00845 236 FFFF 239
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 457-603 4.94e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 67.35  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 457 FITATLWIAVFSY-LMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 535
Cdd:TIGR00367   6 YLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1376476223 536 IPWGLqtmvinygSTVKINSRGLVYSVVLLLGSVALtvLGIHLNKWRLDRKLGIYVLVLYAVFLCFSI 603
Cdd:TIGR00367  86 LSAIF--------SPIIVDKDWLRRDILFYLLVSIL--LLFFGLDGQISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 455-573 1.31e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 67.89  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 455 VTFITATLWIAVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLG-DMAVSNTIGSNVFDILVG 533
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1376476223 534 LGIPWGLQTMV-INYGSTVKINSRGLVYSVVLLLGSVALTV 573
Cdd:TIGR00845 837 IGVAWSIAAIYhAANGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 476-599 1.80e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 62.74  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 476 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINYGSTVKIns 555
Cdd:PRK10734  198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLAFSRD-- 275

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1376476223 556 rglvYSVVLLLgSVALTVLGIhLNKWRLDRKLGIYVLVLYAVFL 599
Cdd:PRK10734  276 ----YWVMLLV-SVIFALLCW-RRKRRIGRGAGALLLGGFIVWL 313
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 471-605 4.82e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.20  E-value: 4.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 471 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGIPWGLQTMVINygST 550
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH--SD 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376476223 551 VKINSRGLVYSVVLLLGSValtvlgihLNKWRLDRKLGIYVLVLYAVFLCFSIMI 605
Cdd:PRK10734  100 VLRRELPLMLLVSVLAGSV--------LYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 98-603 1.85e-09

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 60.55  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  98 GAVLLHI-LGALymFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASvIGVFI--THGDVGVGTIV 174
Cdd:PLN03151  139 GYAVLGVwLVAL--FYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 175 GSAVFNILCIIGVCGL-FAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIYDEEIVWWEGLVLIILYVFYILIMKYNMKMQT 253
Cdd:PLN03151  216 GGAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRK 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 254 F-FTTKQKSIANGNPVSneledGNDLYDGSYDDPSV--PLL-GQVKEKPPYgktpvvmvdeiLSSSPPKFTFpeaglrim 329
Cdd:PLN03151  296 HaRRLKLDVVTPLLPVQ-----GSIFSPSVEEDESMysPLLeSDTESDVPR-----------LQTSLPQWMW-------- 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 330 itnkfgprtrlrmASRIIINERQRLINSANGvNSKPLQNGRHENMENGNVP---------VENPEDPQQGQEQQPPPQPP 400
Cdd:PLN03151  352 -------------ASNVAIYSNHFAKGSVHD-EERPPWGWTDEGAEVESSLfscsklfslLEMPLTIPRRLTIPIVEEDR 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 401 PPEPESVETVFLSP------FSMPEAKGDKAKWVFTWPLIFLLCV--------TIPNcSKPRWEKFFMVT--FITATLWI 464
Cdd:PLN03151  418 WSKTYAVASASLAPvllaflWSSQDDVSLQARIAAYFIGVAIGSTlgflaykyTEPD-RPPRRFLIPWVLggFIMSIVWF 496

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 465 AVFSYLMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGlGD---MAVSNTIGSNVFDILVGLGIPWGLQ 541
Cdd:PLN03151  497 YMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLG 575

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1376476223 542 TMVINYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGIYVLVLYAVFLCFSI 603
Cdd:PLN03151  576 AWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 101-245 2.28e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 56.19  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223 101 LLHILGALYMFYALAIVCDDFFVPSLekiceklhlsedVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 180
Cdd:PRK10734   13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1376476223 181 ILCIIGVCGLFAGQVVRLtwwAVCRDSVYYTLSVIVLIAFI-YDEEIVWWEGLVLIILYVFYILIM 245
Cdd:PRK10734   81 ILLILGLAALIRPFTVHS---DVLRRELPLMLLVSVLAGSVlYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 99-192 1.36e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.33  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376476223  99 AVLLHILGALYMFYALAIVCDDFFVpslekICEKLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAV 178
Cdd:PRK10734  175 AFLWLGIALIIMPMATRMVIDNATV-----LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNI 249

                          90
                  ....*....|....
gi 1376476223 179 FNILCIIGVCGLFA 192
Cdd:PRK10734  250 FNIVIVLGLPALIS 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH