|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
6-1070 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1674.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 6 PENISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882 5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 86 DCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882 85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 166 LYDKGLVYRGVKVMPFSTACGTPLSNFESNQNYKDVQDPSVFVTFPL-EEDENTSLVAWTTTPWTLPSNLALCVNPEIQY 244
Cdd:PLN02882 165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 245 VKIKDVARGKLFILTEARLSALY-------------KQESDYEILERFPGASLKGKKYKPLFDYFIKCKENgAFTVLVDH 311
Cdd:PLN02882 245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADD 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 312 YVKDEEGTGVVHQAPYFGADDHRVCMDFNIIQKDSVPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAG 391
Cdd:PLN02882 324 YVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 392 TFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFVREKRFGNWLKEARDWAISRNRYWGTPIPLWV 471
Cdd:PLN02882 404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 472 SEDLEEVVCIGSVAELEELSGTKISDLHRESIDHLTIPSRCGK--APLRRVSEVFDCWFESGSMPYAQVHYPFESKREFE 549
Cdd:PLN02882 484 SDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFE 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 550 DAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLIN 629
Cdd:PLN02882 564 KNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 630 SPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFFIQNVFRLHKEEEVKFL-YNEHTVRESPNITDRWVLSFMQSLLGFFE 708
Cdd:PLN02882 644 SPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVR 723
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLLI 788
Cdd:PLN02882 724 EEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVL 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 789 DPASlrdkdtLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALEDIR-SLE 867
Cdd:PLN02882 804 PGSE------ESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKLK 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 868 KYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMMAIKRLSNEELERFQKSGSIVVEGHELHEEDIRL 947
Cdd:PLN02882 878 EYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIKV 956
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 948 MYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYN--AKSEGRYLNN 1024
Cdd:PLN02882 957 VRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDEVDESALSQ 1036
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*.
gi 254553372 1025 VIESHTDFIFATIKAPLKPYPVPTSDNILIQEQTQLKGSELEITLT 1070
Cdd:PLN02882 1037 VLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSFKIS 1082
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-1032 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1139.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 5 VPENISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 85 WDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00427 148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 165 QLYDKGLVYRGVKVMPFSTACGTPLSNFESNQNYKDVQDPSVFVTF-------------PLEED---------------- 215
Cdd:PTZ00427 228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDkqllgekysvlynnkr 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 216 ------ENTS-----------LVAWTTTPWTLPSNLALCVNPEIQYVKIKDVARGKLFILTEARLSALYKQ----ESDYE 274
Cdd:PTZ00427 308 ensnngNNNStnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKElkwnVEDLK 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 275 ILERFPGASLKGKKYKPLFDYFIKcKEN---GAFTVLVDHYVKDEEGTGVVHQAPYFGADDHRVCMDFNIIQKDS-VPVC 350
Cdd:PTZ00427 388 IVNRFKGKELKGLRYKPLFTNFYE-KYNfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKnIFID 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 351 PVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNN 430
Cdd:PTZ00427 467 PLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 431 DLCYWVPEFVREKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVCIGSVAELEELSGTK-ISDLHRESIDHLTIP 509
Cdd:PTZ00427 547 ETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIEIK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 510 SRCGKA--PLRRVSEVFDCWFESGSMPYAQVHYPFESKRE-FEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN 586
Cdd:PTZ00427 627 NPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 587 VIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFFIQN 666
Cdd:PTZ00427 707 LICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQE 786
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 667 VFRLHKEEEVKFLYNEHTVRESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGES 746
Cdd:PTZ00427 787 VTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGSL 866
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 747 GVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLL--------------IDPASLRDKDT-LSIHYLMLPRVRE 811
Cdd:PTZ00427 867 GEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVkstnehnennetgnTKEGDLNRGVIhKSVHFIMLPQVDE 946
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 812 E-LIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALEDIRSLEKYIIEELNVRKVTLSTDKNkyGI 890
Cdd:PTZ00427 947 KyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS--CL 1024
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 891 RLRAEPDHMVLGKRLKGAFKAVMMAIKRLSNEELERFQKSGSIVVEGHELHEEDI--RLMYTF-DQATggtaqfEAHSDA 967
Cdd:PTZ00427 1025 DFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFqNDNT------DIISNN 1098
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 968 QALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEI---------TVYYNAKSEGRYLN-------NVIESHTD 1031
Cdd:PTZ00427 1099 YVTILMDFTTDQQLENMASARELCNHIQKMRKNLSLNQNSPVkmhvyiaddTLRNNMVSEMEYIKkclrrelNVIPSQED 1178
|
.
gi 254553372 1032 F 1032
Cdd:PTZ00427 1179 Y 1179
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-997 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1051.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 6 PENISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 86 DCHGLPVEYEIDKTLGIKGPeDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:COG0060 93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 166 LYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVFVTFPLEED------ENTSLVAWTTTPWTLPSNLALCVN 239
Cdd:COG0060 172 LYEKGLLYKGLKPVPWCPRCGTALAEAEVE--YKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 240 PEIQYVKIKdVARGKLFILTEARLSALYK--QESDYEILERFPGASLKGKKYKPLFDYFIKckENGAFTVLVDHYVKDEE 317
Cdd:COG0060 250 PDIDYVLVE-VTGGERLILAEALVEAVLKelGIEDYEVLATFKGAELEGLRYEHPFYYVVG--YDRAHPVILGDYVTTED 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 318 GTGVVHQAPYFGADDHRVCMDFNIiqkdsVPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAGTFTHSY 397
Cdd:COG0060 327 GTGIVHTAPGHGEDDFEVGKKYGL-----PVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 398 PFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFvREKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEE 477
Cdd:COG0060 402 PHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 478 VV----CIGSVAELEELSGTKIS---DLHRESIDHlTIPSRCGKAPLRRVSEVFDCWFESGSMPYAQVhypfeSKREfED 550
Cdd:COG0060 481 LHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL-----ENRE-EL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 551 AFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINS 630
Cdd:COG0060 554 HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASS 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 631 PvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFFIQNvfrLHkeeevKFLYNEHTVR-ESPNITDRWVLSFMQSLLGFFET 709
Cdd:COG0060 634 D--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLAN---LD-----DFDPAEDAVPyEDLPELDRWILSRLNELIKEVTE 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 710 EMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKll 787
Cdd:COG0060 703 AYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP-- 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 788 idpaslrDKDTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGR----VIRDRKTipIKYPLKEIVVIHQDPEALEDI 863
Cdd:COG0060 781 -------GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEELAAAL 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 864 RSLEKYIIEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmmaikrlsneelerfqksgsivvegheLHEE 943
Cdd:COG0060 852 ESLGDLLAEELNVSEVELVDDAEDLG----------------KDALKA----------------------------LDVE 887
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....
gi 254553372 944 DIRLMYTFDQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 997
Cdd:COG0060 888 GISVTVEVEKADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-863 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 986.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 5 VPENISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392 2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 85 WDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:TIGR00392 82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 165 QLYDKGLVYRGVKVMPFSTACGTPLSNFESNQ--NYKDVQDPSVFVTFPLEEDENT-------SLVAWTTTPWTLPSNLA 235
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKKTylkvklsSLLIWTTTPWTLPSNLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 236 LCVNPEIQYVKIKDVARGKLFILTEARLSALYKQE-SDYEILERFPGASLKGKKYKPLFDYFIKCKENGAFTVLVDHYVK 314
Cdd:TIGR00392 242 IAVHPDFEYALVQDNTKVEYFILAKKLVEKLYNKAgSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 315 DEEGTGVVHQAPYFGADDHRVCmdfniiQKDSVPV-CPVDASGCFTEEVTHFVGQYVKDADKN-------IIRMLKEQGR 386
Cdd:TIGR00392 322 TEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDiikankiIIEQLKDKGL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 387 LLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFVrEKRFGNWLKEARDWAISRNRYWGTP 466
Cdd:TIGR00392 396 LLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIP 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 467 IPLWVSEDLEEVVCIGSVAELEELSGTK-----ISDLHRESIDHLTIPS-RCGKapLRRVSEVFDCWFESGSMPYAQVHY 540
Cdd:TIGR00392 475 IPIWYCEDTGEPIVVGSIEELIELIELKgidawFEDLHRDFLDKITLKSgDGGE--YRRVPDVLDVWFDSGSMPYASIHY 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 541 PFESKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGA 620
Cdd:TIGR00392 553 PFENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGA 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 621 DALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFFIQ--NVFRLhkeeevKFLYNEHTVRESPNItDRWVLS 698
Cdd:TIGR00392 632 DILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKF------DPLFNSVAVEKFPEE-DRWILS 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 699 FMQSLLGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLT 777
Cdd:TIGR00392 703 RLNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTA 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 778 ELMYQNLKllidpaslRDKDTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDP 857
Cdd:TIGR00392 783 EEIYQNLP--------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLE 854
|
....*.
gi 254553372 858 EALEDI 863
Cdd:TIGR00392 855 AVLKAV 860
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-639 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 927.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 17 KILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEI 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 97 DKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 177 KVMPFSTACGTPLSNFESnqNYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKikdvaRGKLF 256
Cdd:pfam00133 161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 257 ILTEARLSALYKQESDYEILERFPGASLKGKKYKPLFdyfikckENGAFTVLVDHYVKDEEGTGVVHQAPYFGADDHRVC 336
Cdd:pfam00133 234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 337 MDFNIiqkdsVPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDTPLIYKSVPSWF 416
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 417 VRVEPMVDQLLKNNDLCYWVPEFvREKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVCIGSVAELEEL---SGT 493
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 494 KISDLHRESIDHLtipsRCGKAPLRRVSEVFDCWFESGSMPYAQVHYPFESKREFEDAFPADFIAEGIDQTRGWFYTLLV 573
Cdd:pfam00133 461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254553372 574 LATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
6-937 |
1.88e-126 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 410.99 E-value: 1.88e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 6 PENISFPAEEEKILEFWSKHNCFQecLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:TIGR00422 2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 86 DCHGLPVEYEIDKTLGIKGPE--DVakmGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVF 163
Cdd:TIGR00422 80 DHAGIATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 164 KQLYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEiq 243
Cdd:TIGR00422 157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 244 yvkikdvargklfiltearlsalykqesDyeilERFpgASLKGKKYK-PLFDYFIKckengaftVLVDHYVKDEEGTGVV 322
Cdd:TIGR00422 233 ----------------------------D----ERY--KHLIGKKVIlPLTGRKIP--------IIADEYVDMEFGTGAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 323 HQAPyfgADDHRvcmDFNIIQKDSVP-VCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCW 401
Cdd:TIGR00422 271 KVTP---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCW 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 402 RSDTPL-IYKSvPSWFVRVEPMVDQLLK--NNDLCYWVPEFVrEKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEV 478
Cdd:TIGR00422 345 RSGTVVePLLS-KQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEV 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 479 VcigsVAELEELSGTKISDlhresidhltipsrCGKAPLRRVSEVFDCWFESGSMPYAQVHYPfESKREFEDAFPADFIA 558
Cdd:TIGR00422 423 Y----VAKEEPLPDDKTNT--------------GPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLV 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 559 EGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSpVVRAENL 638
Cdd:TIGR00422 484 TGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDI 562
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 639 RFKE---EGVRDVLKDVllpwYNAYRFFIQNvfrlhkEEEVKFLYNEHtvrESPNITDRWVLSFMQSLLGFFETEMAAYR 715
Cdd:TIGR00422 563 NFDWkrvESARNFLNKL----WNASRFVLMN------LSDDLELSGGE---EKLSLADRWILSKLNRTIKEVRKALDKYR 629
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 716 LYTVVPRLVKFV-DILTNWYVRMNRRRLKGESgVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKllidpaslr 794
Cdd:TIGR00422 630 FAEAAKALYEFIwNDFCDWYIELVKYRLYNGN-EAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK--------- 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 795 dKDTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALEDIRSLEKYIIEEL 874
Cdd:TIGR00422 700 -EGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAI 777
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254553372 875 NVRKVTLSTDKNKYGIRL-RAEPDHMVLG--KRLKGAFKAVMMAIKRLSNEELERFQKSGSIVVEG 937
Cdd:TIGR00422 778 NFSEVEVVIEKPEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEG 843
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
406-640 |
3.73e-110 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 349.22 E-value: 3.73e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 406 PLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFVREkRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVCigsva 485
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV----- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 486 eleelsgtkisdlhresidhltipsrcgkaplRRVSEVFDCWFESGSMPYAQVHYPFESKrEFEDAFPADFIAEGIDQTR 565
Cdd:cd00818 218 --------------------------------RRVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTR 264
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254553372 566 GWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818 265 GWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-885 |
1.03e-107 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 358.35 E-value: 1.03e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 1 MVQQVPENISFPAEEEKILEFWSKHNCFQEclKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVD 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 81 RRFGWDCHGLPVEYEIDKTLGIKgPEDVAKmgiAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTlypqfMESVW 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQT-----ISPEY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 161 WV-----FKQLYDKGLVYRGVKVMPFSTACGTPLSNFEsnQNYKDVQDPSVFVTFPLEEDEntSLVAWTTTPWTLPSNLA 235
Cdd:PRK13208 151 RRisqksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVEDGE--EIEIATTRPELLPACVA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 236 LCVNPEiqyvkikdvargklfiltearlsalykqesDyeilERFpgASLKGKKYK-PLFDYFIKckengaftVLVDHYVK 314
Cdd:PRK13208 227 VVVHPD------------------------------D----ERY--KHLVGKTAIvPLFGVEVP--------ILADPLVD 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 315 DEEGTGVVHqapyfgaddhrVC-----MDFNIIQKDSVPVCPV-DASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLL 388
Cdd:PRK13208 263 PDFGTGAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLG 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 389 AAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEFVReKRFGNWLKE-ARDWAISRNRYWGTPI 467
Cdd:PRK13208 332 KQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPI 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 468 PLWVSEDLEEVVcigsVAELEELSGTKISDL---HRESidhltipsRCGKAPLRRVSEVFDCWFESGSMPYAQVHYPFES 544
Cdd:PRK13208 411 PVWYCKDCGHPI----LPDEEDLPVDPTKDEppgYKCP--------QCGSPGFEGETDVMDTWATSSITPLIVTGWERDE 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 545 KReFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADAL 623
Cdd:PRK13208 479 DL-FEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAV 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 624 RLYLINSPVvrAENLRFKEEGVRdvlkdvllpwyNAYRFFIQ--NVFRLhkeeeVKFLyNEHTVRESPNIT---DRWVLS 698
Cdd:PRK13208 557 RYWAASARL--GSDTPFDEKQVK-----------IGRRLLTKlwNASRF-----VLHF-SADPEPDKAEVLeplDRWILA 617
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 699 FMQSLLGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLT 777
Cdd:PRK13208 618 KLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFIT 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 778 ELMYQNLKllidpaslrdkdTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIhqDP 857
Cdd:PRK13208 698 EEVWSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVY--GP 763
|
890 900
....*....|....*....|....*...
gi 254553372 858 EALEDIRSLEKYIIEELNVRKVTLSTDK 885
Cdd:PRK13208 764 ADLELLEAAEEDLKAAGNIEELELVEGD 791
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
15-792 |
1.31e-103 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 351.77 E-value: 1.31e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 15 EEKILEFWSKHNCFQECLKQSKLRPkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEY 94
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 95 EIDKTLGIKGPEDvakMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYR 174
Cdd:PLN02843 88 KVLQSLDQEARKE---LTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 175 GVKVMPFSTACGTPLSnfESNQNYKDVQ-DPSVFVTFPL---------EEDE---NTSLVAWTTTPWTLPSNLALCVNPE 241
Cdd:PLN02843 165 GRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpGLSLAIWTTTPWTMPANAAVAVNDK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 242 IQY--VKIKDV--------------------ARGKLFILTEARL-SAL-YKQESDYEILERFPGASLKGKKYK-PLFDYf 296
Cdd:PLN02843 243 LQYsvVEVQSFsedestsggnkkkrpgnvlkEQQKLFLIVATDLvPALeAKWGVKLVVLKTFPGSDLEGCRYIhPLYNR- 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 297 iKCKengafTVLVDHYVKDEEGTGVVHQAPYFGADDHRVCMdfniiqKDSVP-VCPVDASGCFTEEVTHFVGQYV-KDAD 374
Cdd:PLN02843 322 -ESP-----VVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlLSPVDDAGKFTEEAGQFSGLSVlGEGN 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 375 KNIIRMLKEQGRLLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLKNNDLCYWVPEfVREKRFGNWLKEARD 454
Cdd:PLN02843 390 AAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMVSGRSD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 455 WAISRNRYWGTPIPLWVSEDLEEVVCIGS-VAELEELSGTKISDLHRE-SIDHLTIPSRCGKAP-LRRVSEVFDCWFESG 531
Cdd:PLN02843 469 WCISRQRTWGVPIPVFYHVETKEPLMNEEtIAHVKSIVAQKGSDAWWYmDVEDLLPEKYRDKASdYEKGTDTMDVWFDSG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 532 SmPYAQVhypfeSKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDP 611
Cdd:PLN02843 549 S-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDP 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 612 VSIID---------KYGADALRLY----------LINSPVVR--AENLRfkeeGVRDVLkdvllpwynayRFFIQNVFRL 670
Cdd:PLN02843 623 RLVIEggknqkqepAYGADVLRLWvasvdytgdvLIGPQILKqmSDIYR----KLRGTL-----------RYLLGNLHDW 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 671 HKEEEVKFlynehtvrESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGESGVE 749
Cdd:PLN02843 688 KPDNAVPY--------EDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNFYLDVAKDRLYVGGTTS 759
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 254553372 750 DCVMALET-LFSVLLSLCRLMAPYTPFLTELMYQNLKLLIDPAS 792
Cdd:PLN02843 760 FTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSA 803
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-181 |
4.85e-85 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 280.66 E-value: 4.85e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNK 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254553372 119 QCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPF 181
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
640-833 |
5.60e-82 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 265.95 E-value: 5.60e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 640 FKEEGVRDVLKDVLLPWYNAYRFFIQNVFRLHKEEEVKFLYNEhtvreSPNITDRWVLSFMQSLLGFFETEMAAYRLYTV 719
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVA-----SLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 720 VPRLVKFVDILTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLLIdpaslrDKDTL 799
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRREL------GDAPE 149
|
170 180 190
....*....|....*....|....*....|....
gi 254553372 800 SIHYLMLPRVREELIDKKTENAVSRMQSVIELGR 833
Cdd:cd07961 150 SVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-885 |
3.44e-70 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 253.82 E-value: 3.44e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 12 PAE-EEKILEFWSKHNCFQeclkqSKLRPkftfyDGPPFA--------TGLPHYGHILAGTIKDIVTRYAHQSGFhvdrr 82
Cdd:COG0525 9 PKEvEAKWYQYWEENGYFK-----ADPDS-----DKEPFTivipppnvTGSLHMGHALNNTLQDILIRYKRMQGY----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 83 fgwdchglpveyeidKTLGIKGpEDVAkmGIAEYNKqcraiVMRYSA-------------------EWK----STVT--- 136
Cdd:COG0525 74 ---------------NTLWQPG-TDHA--GIATQAV-----VERQLAeegksrhdlgrekflervwEWKeesgGTITnql 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 137 -RLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVFVTFPLEED 215
Cdd:COG0525 131 rRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--HEEVKGHLWHIRYPLADG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 216 ENTSLVAwTTTPWTLPSNLALCVNPEiqyvkikdvargklfiltearlsalykqesDyeilERFpgASLKGKKYK-PLFD 294
Cdd:COG0525 209 SGYIVVA-TTRPETMLGDTAVAVHPE------------------------------D----ERY--KHLIGKTVIlPLVG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 295 YFIKckengaftVLVDHYVKDEEGTGVV-----HqapyfgaddhrvcmDFN---IIQKDSVPVCPV-DASGCFTEEVTHF 365
Cdd:COG0525 252 REIP--------IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINIlDEDGTINENAGKY 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 366 VGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDT---PLIyksvpS--WFVRVEPMVDQLLK--NNDLCYWVPE 438
Cdd:COG0525 310 RGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEavEDGEIKFVPE 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 439 -FvrEKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDlEEVVcigsVAELEElsgtkisdlhresidhlTIPSRCGKAPL 517
Cdd:COG0525 385 rW--EKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVY----VARTEP-----------------EACAKAGSVNL 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 518 RRVSEVFDCWFESGSMPYAQVHYPFESKrEFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------G 580
Cdd:COG0525 441 TQDEDVLDTWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftG 502
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 581 QPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI--NSPvvrAENLRFKEEgvrdvlkdvllpWYN 658
Cdd:COG0525 503 EVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEE------------RVE 567
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 659 AYRFF---IQNVFRLHKEEEVKFLYNEHTVRESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFV-DILTNWY 734
Cdd:COG0525 568 GYRNFankLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWY 647
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 735 VRMNRRRLKGESGVEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLLIDPASlrdkdtlsihyLML---PRVRE 811
Cdd:COG0525 648 LELAKPRLYGGDEAAKRE-TRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES-----------IMLapwPEADE 715
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254553372 812 ELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALEDIRSLEKYIIEELNVRKVTLSTDK 885
Cdd:COG0525 716 ELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
15-867 |
3.84e-70 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 256.07 E-value: 3.84e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 15 EEKILEFWSKHNCFQeCLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLP--- 91
Cdd:PRK14900 25 EARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAtqm 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 92 -VEYEIDKTLGiKGPEDvakMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKG 170
Cdd:PRK14900 104 iVEKELKKTEK-KSRHD---LGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 171 LVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVF-VTFPLEEDENTSLVAwTTTPWTLPSNLALCVNPEiqyvkikd 249
Cdd:PRK14900 180 LIYREKKLINWCPDCRTALSDLEVE--HEEAHQGELWsFAYPLADGSGEIVVA-TTRPETMLGDTAVAVHPL-------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 250 vargklfiltEARLSALYKQESDYEILERfpgaslkgkkykplfdyfikckengAFTVLVDHYVKDEE-GTGVVHQAPyf 328
Cdd:PRK14900 249 ----------DPRYMALHGKKVRHPITGR-------------------------TFPIVADAILVDPKfGTGAVKVTP-- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 329 gADDHRvcmDFNIIQKDSVPVCPV-DASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGrlLAAGTFTHSYPF--CWRSDT 405
Cdd:PRK14900 292 -AHDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrCQRSAT 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 406 PLIYKSVPSWFVRVEPMVDQLLK--NNDLCYWVPEFVREKRFGnWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVCigs 483
Cdd:PRK14900 366 ILEPLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA--- 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 484 vaeleelsgtkisdlhRESidhltiPS---RCGKAPLRRVSEVFDCWFESGSMPYAQVHYPfESKREFEDAFPADFIAEG 560
Cdd:PRK14900 442 ----------------RET------PEacsTCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETG 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 561 IDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLInSPVVRAENLRF 640
Cdd:PRK14900 499 HDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKL 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 641 KE---EGVRDVLKDVllpwYNAYRFFIQNVfrlhkeeevkflyNEHTVRESP------NITDRWVLSFMQSLLGFFETEM 711
Cdd:PRK14900 578 AKeriEGYRAFANKL----WNASRFALMNL-------------SGYQERGEDparlarTPADRWILARLQRAVNETVEAL 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 712 AAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGE-SGVEDCVMAleTLFSVLLSLCRLMAPYTPFLTELMYQNLKLLID 789
Cdd:PRK14900 641 EAFRFNDAANAVYAFVwHELCDWYIELAKEALASEdPEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVLRAQVG 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 790 PASLRDkdtlSIHYLMLPRVREelIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPL---KEIVVIHQDPEALEDIRSL 866
Cdd:PRK14900 719 ASAWAD----SVLAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPALRDLLQAG 792
|
.
gi 254553372 867 E 867
Cdd:PRK14900 793 E 793
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
12-922 |
6.17e-70 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 252.72 E-value: 6.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 12 PAE-EEKILEFWSKHNCFQeclKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFhvdrrfgwdchgl 90
Cdd:PRK05729 11 PKEvEAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGY------------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 91 pveyeidKTLGIKGpEDVAkmGIAEYNKqcraiVMRYSA-------------------EWK----STVT----RLGRWID 143
Cdd:PRK05729 75 -------NTLWLPG-TDHA--GIATQMV-----VERQLAaegksrhdlgrekflekvwEWKeesgGTITnqlrRLGASCD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 144 FDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVFVTFPLEEDENTSLVAw 223
Cdd:PRK05729 140 WSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--YKEVKGKLWHIRYPLADGSDYLVVA- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 224 TTTPWTLPSNLALCVNPEiqyvkikdvargklfiltearlsalykqesDyeilERFpgASLKGKKYK-PLFDYFIKcken 302
Cdd:PRK05729 217 TTRPETMLGDTAVAVNPE------------------------------D----ERY--KHLIGKTVIlPLVGREIP---- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 303 gaftVLVDHYVKDEEGTGVV-----HqapyfgaddhrvcmDFN---IIQKDSVPVCPV-DASGCFTEEVTHFVGQYVKDA 373
Cdd:PRK05729 257 ----IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPGEYQGLDRFEA 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 374 DKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDTPL-IYKSvPSWFVRVEPMVDQLLK--NNDLCYWVPE-FvrEKRFGNWL 449
Cdd:PRK05729 319 RKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIePYLS-DQWFVKMKPLAKPALEavENGEIKFVPErW--EKTYFHWM 395
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 450 KEARDWAISRNRYWGTPIPLWVSEDlEEVVcigsVAELEelsgtkisdlhresidhltiPSRCGKAPLRRVSEVFDCWFE 529
Cdd:PRK05729 396 ENIQDWCISRQLWWGHRIPAWYDED-GEVY----VGREE--------------------PEAREKALLTQDEDVLDTWFS 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 530 SGSMPYAQVHYPfESKREFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQPPFKNVIVNGL 592
Cdd:PRK05729 451 SALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGQVPFKDVYIHGL 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 593 ILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI--NSPvvrAENLRFKEEgvrdvlkdvllpWYNAYRFF---IQNV 667
Cdd:PRK05729 513 VRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEE------------RVEGYRNFankLWNA 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 668 FR--LHKEEEVKFLYNEHtvRESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKG 744
Cdd:PRK05729 578 SRfvLMNLEGADVGELPD--PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLELAKPVLQE 655
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 745 ESGVEdcvmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKLLIDPASlrdkdtlsihyLML---PRVREELiDKKTENA 821
Cdd:PRK05729 656 AAKRA----TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEES-----------IMLapwPEADEAI-DEAAEAE 719
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 822 VSRMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALEDIRSLEKYI-----IEELNVRKVTLSTDKNKY-----GIR 891
Cdd:PRK05729 720 FEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIkrlarLESLEILADDEEAPEGAAsavvgGAE 798
|
970 980 990
....*....|....*....|....*....|....*....
gi 254553372 892 LRAEPDHMV--------LGKRLKGAFKAVMMAIKRLSNE 922
Cdd:PRK05729 799 LFLPLEGLIdveaelarLEKELAKLEKEIERVEKKLSNE 837
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
47-630 |
2.07e-57 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 203.63 E-value: 2.07e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 47 PPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDvAKMGIAEYNKQCRAIVMR 126
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 127 YSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLsnfesnqnykdvqdpsv 206
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAI----------------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 207 fvtfpleedentslvawtttpwtlpsnlalcvnpeiqyvkikdvargklfiltearlsalykqeSDYEILERfpgaslkg 286
Cdd:cd00817 151 ----------------------------------------------------------------SDIEVCSR-------- 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 287 kkykplfdyfikckengaftvlvdhyvkdeegtgvvhqapyfgaddhrvCMDfniiqkdsvPVCPvdasgcfteevthfv 366
Cdd:cd00817 159 -------------------------------------------------SGD---------VIEP--------------- 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 367 gqyvkdadkniirMLKEQgrllaagtfthsypfcwrsdtpliyksvpsWFVRVEPMVDQLLK--NNDLCYWVPEFVrEKR 444
Cdd:cd00817 166 -------------LLKPQ------------------------------WFVKVKDLAKKALEavKEGDIKFVPERM-EKR 201
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 445 FGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVVcigsVAELEELSGTKISDLHREsidhltipsRCGKAPLRRVSEVF 524
Cdd:cd00817 202 YENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWV----VAREEDEAIDKAAPEACV---------PCGGEELKQDEDVL 268
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 525 DCWFESGSMPYAQVHYPfESKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLILASDGQKMSK 603
Cdd:cd00817 269 DTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSK 346
|
570 580
....*....|....*....|....*..
gi 254553372 604 RKKNYPDPVSIIDKYGADALRLYLINS 630
Cdd:cd00817 347 SLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-784 |
1.22e-54 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 207.49 E-value: 1.22e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 13 AEEEKILEFWSKHNCFQECLKQSKlrPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PLN02943 64 TSEERIYNWWESQGYFKPNFDRGG--DPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 93 EYEIDKTLGIKGPEDVaKMGIAEYNKQCRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PLN02943 142 QLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 173 YRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPE----IQYVkik 248
Cdd:PLN02943 221 YQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPEddrySKYI--- 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 249 dvarGKLFILtearlsalykqesdyeilerfpgaSLKGKKYKPlfdyfikckengaftVLVDHYVKDEEGTGVVHQAPyf 328
Cdd:PLN02943 296 ----GKMAIV------------------------PMTYGRHVP---------------IIADRYVDKDFGTGVLKISP-- 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 329 gADDHRvcmDFNIIQKDSVPVCPVDASGCFTEEVThfvGQYVKDADKNIIRMLKEQGRLLAAGTFTHSYPFCWRSDT--- 405
Cdd:PLN02943 331 -GHDHN---DYLLARKLGLPILNVMNKDGTLNEVA---GLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEvie 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 406 PLIYKSvpsWFVRVEPMVDQLLK---NNDLCYWVPEFvrEKRFGNWLKEARDWAISRNRYWGTPIPLW--VSEDLEEVVC 480
Cdd:PLN02943 404 PLVSKQ---WFVTMEPLAEKALKaveNGELTIIPERF--EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEEDYI 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 481 igsVAELEELSGTKISDLHRESIDhltipsrcgkapLRRVSEVFDCWFESGSMPYAQVHYPFESKREFEDAFPADFIAEG 560
Cdd:PLN02943 479 ---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETG 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 561 IDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSPVVRAENLRF 640
Cdd:PLN02943 544 HDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLST 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 641 KEEGVRDVLKDVLlpwYNAYRFFIQNVFRLHKEEEVKFLYN-----EHTVRESPnITDRWVLSFMQSLLGFFETEMAAYR 715
Cdd:PLN02943 624 ERLTSNKAFTNKL---WNAGKFVLQNLPSQSDTSAWEHILAckfdkEESLLSLP-LPECWVVSKLHELIDSVTTSYDKYF 699
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 716 LYTVVPRLVKFV-DILTNWYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:PLN02943 700 FGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL 769
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-878 |
2.95e-50 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 194.07 E-value: 2.95e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 15 EEKILEFWSKHNCFQ--ECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLP- 91
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAt 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 92 ---VEYEIDKTLGIK----GPEDVAKMgIAEYNKQcraivmrYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00419 114 qvvVEKKLMKEENKTrhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 165 QLYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPSVF----------------VTFPLEEDENTSLVAWTTTPW 228
Cdd:PTZ00419 186 RLYEDGLIYRDTRLVNWCCYLKTAISDIEVE--FEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 229 TLPSNLALCVNPeiqyvkiKDvargklfiltearlsalykqesdyeilERFpgASLKGKKYK-PLF-DYFIKckengafT 306
Cdd:PTZ00419 264 TMLGDVAVAVHP-------KD---------------------------ERY--KKLHGKELIhPFIpDRKIP-------I 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 307 VLVDHYVKDEEGTGVVHQAPyfgADDHRvcmDFNIIQKDSVPVCPV-DASGCFTEEVTHFVGQYVKDADKNIIRMLKEQG 385
Cdd:PTZ00419 301 IADDELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEEELKEMG 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 386 RLLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVEPMVDQ---LLKNNDLCYWVPEFVREkrFGNWLKEARDWAISRNRY 462
Cdd:PTZ00419 375 LLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRaveAVRNGELKIIPSSHENV--WYHWLENIQDWCISRQLW 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 463 WGTPIP-----------------LWV-SEDLEEvvCIGSVAELEELSGTKISdlhresidhltipsrcgkapLRRVSEVF 524
Cdd:PTZ00419 453 WGHRIPayrviskgpetdpsdeePWVvARSEEE--ALEKAKKKFGLSEEDFE--------------------LEQDEDVL 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 525 DCWFESGSMPYAQVHYPFESKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKR 604
Cdd:PTZ00419 511 DTWFSSGLFPFSTLGWPDQTD-DLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKS 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 605 KKNYPDPVSIIDKYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV------ 652
Cdd:PTZ00419 590 KGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrvvgy 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 653 ------LlpWyNAYRFFIQNVFRLHKeeEVKFLYNEHTVRESPNITDRWVLSFMQSLLG----------FFETEMAAYRL 716
Cdd:PTZ00419 670 rhfcnkL--W-NAVKFALMKLLKDFN--LPNSTLFKPNNVESLPWEDKWILHRLNVAIKevtegfkeydFSEATQATYNF 744
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 717 YtvvprLVKFVDIltnwYVRMNRRRLKGESGVEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLkllidPASLRDK 796
Cdd:PTZ00419 745 W-----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----PNYLRKS 810
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 797 DTLSI-HYlmlPRVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIVVIHqDPEALEDIRSLEKYI----- 870
Cdd:PTZ00419 811 ESISIaKY---PQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAK-DAELIELIESAENLIstlak 886
|
....*...
gi 254553372 871 IEELNVRK 878
Cdd:PTZ00419 887 IGSVSVIP 894
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
407-628 |
1.58e-49 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 178.38 E-value: 1.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 407 LIYKS------VPSWFVRVEPMVDQLLKNNDLCYWVPEFVReKRFGNWLKEARDWAISRNRYWGTPIPLWVsedleevvc 480
Cdd:cd00668 128 LIYRGthpvriTEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAISRQRYWGTPLPEDV--------- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 481 igsvaeleelsgtkisdlhresidhltipsrcgkaplrrvsevFDCWFESGSMPYAQVHYPFEsKREFEDAFPADFIAEG 560
Cdd:cd00668 198 -------------------------------------------FDVWFDSGIGPLGSLGYPEE-KEWFKDSYPADWHLIG 233
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254553372 561 IDQTRGWFYTLLVLATALFGQPPFKNVIVNGLILASDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI 628
Cdd:cd00668 234 KDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLT 301
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
15-870 |
4.34e-40 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 161.07 E-value: 4.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 15 EEKILEFWSKHNCFQECLKQSKlrPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVE- 93
Cdd:TIGR00396 7 EEKWQQKWDENKTFKVTDDSSK--PKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAEn 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 94 YEIDKTlgiKGPEDVAKMGIAEYNKQCRAivmrysaewkstvtrLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVY 173
Cdd:TIGR00396 85 AAIKRG---IHPAKWTYENIANMKKQLQA---------------LGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAY 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 174 RgvKVMPF--------------------STACGTPLSNFESNQ------------------------NYKDVQ------D 203
Cdd:TIGR00396 147 V--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPVEKKELKQwflkitayaeellndleeldhwpeSVKEMQrnwigkS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 204 PSVFVTFPLEeDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKikdvargkLFILTEARLSALYKQESDYEILERFP--- 280
Cdd:TIGR00396 225 EGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVE--------KAAENNPKVAAFIKKILNKTVAERTKatk 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 281 ---GASLKGKKYKPLfdyfikckENGAFTVLVDHYVKDEEGTGVVHQAPyfgADDHRvcmDFNIIQKDSVPVCPVdasgc 357
Cdd:TIGR00396 296 ekkGVDTGIKAIHPL--------TGEKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKPV----- 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 358 fteevthfvgqyVKDADKNII--RMLKEQGRLLAAGTFTHSypfcwrsDTPLIYKSVPSWFVrvepmvdqllKNNdlcyw 435
Cdd:TIGR00396 357 ------------IDPAEKDLSltAAYTEDGVLVNSGEFNGL-------NSSEARNAIIDMLE----------KEG----- 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 436 vpefvREKRFGNWlkEARDWAISRNRYWGTPIPLWVSED------LEEVVCIgSVAELEELSGTKISDLHR-ESIDHLTI 508
Cdd:TIGR00396 403 -----KGKRKVNY--RLRDWGFSRQRYWGEPIPIIHCEDggvvpvPEEDLPV-ILPEDVVYDGDGGSPLSRiPEWVNVTC 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 509 PSrCGKaPLRRVSEVFDCWFESG--SMPYAQVHYP--FESKREFEDAFPADFIAEGIDQT-------RgWFYTLLVLATA 577
Cdd:TIGR00396 475 PS-CGK-PALRETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaR-FFHKFLRDIGY 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 578 LFGQPPFKNVIVNGLILA-------------------------------SDGQKMSKRKKNYPDPVSIIDKYGADALRLY 626
Cdd:TIGR00396 552 VNTKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADALRLF 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 627 LI-NSPVvrAENLRFKEEGVrdvlkdvllpwyNAYRFFIQNVFRL---HKEEEVKFLYNEHTVRESPNITDRWVLSFMQS 702
Cdd:TIGR00396 632 IMfMGPI--AASLEWNESGL------------EGARRFLDRVWNLvyeITGELDAASLTVTALEEAQKELRRDVHKFLKK 697
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 703 LLGFFEtemAAYRLYTVVPRLVKFVDILTNwyvrmnrrrlkgesgVEDCVMALETLFSVLlslcRLMAPYTPFLTELMYQ 782
Cdd:TIGR00396 698 VTEDLE---KRESFNTAISAMMELLNKLYK---------------AKKEALMLEYLKGFV----TVLSPFAPHLAEELWE 755
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 783 NLKLLidpaslrdkdTLSIHYLMLPRVREELIDKktenavSRMQSVIELGRVIRDRKTIPIKYPLKEIVVI-HQDPEALE 861
Cdd:TIGR00396 756 KLGSE----------PFIIDNAKWPVVDETALVE------DKTLIVVQVNGKFRAKITVPKDADEEQVEELaKQDPEVKK 819
|
970
....*....|.
gi 254553372 862 DI--RSLEKYI 870
Cdd:TIGR00396 820 YLenKTIKKVI 830
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-950 |
2.84e-39 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 158.49 E-value: 2.84e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 54 PHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV-----------EYEID---KTLGIkgPEDV-AKMG----IA 114
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdPETIElykSLYGI--PEEElEKFKdpeyIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 115 EYnkqcraivmrYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNfes 194
Cdd:PRK12300 79 EY----------FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGD--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 195 nQNYKDVQDPSV--FVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKIKdvARGKLFILTEArlsALYK---Q 269
Cdd:PRK12300 146 -HDLLDGEEPEIveYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE---AAEKlsfQ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 270 ESDYEILERFPGASLKGKKYK-PLFDYFIKckengaftVLVDHYVKDEEGTGVV-----HqAPYfgadDHRVCMDFNIIQ 343
Cdd:PRK12300 220 DRDVEIIEEIKGSELIGKKVKnPVTGKEVP--------ILPADFVDPDNGTGVVmsvpaH-APY----DYVALRDLKKNK 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 344 KDS-----VPVCPVD------------------------------------ASGCFTEEVTHFVGQYVKDADKNIIRMLK 382
Cdd:PRK12300 287 ELLdviepIPLIEVEgygefpakevveklgiksqedpeleeatkevyraefHKGVLKENTGEYAGKPVREAREKITKDLI 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 383 EQGrllAAGTFthsYPF------CwRSDTPLIYK----------SVPSWFVRVEPMVDQLlknnDLcywVPEFVReKRFG 446
Cdd:PRK12300 367 EKG---IADIM---YEFsnrpvyC-RCGTECVVKvvkdqwfidySDPEWKELAHKALDNM----EI---IPEEYR-KEFE 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 447 N---WLKearDWAISRNRYWGTPIPL---WVSEDLEEvvcigS--------VAELEELSGTKISDLHRESIDHLTIpsrc 512
Cdd:PRK12300 432 NtidWLK---DRACARRRGLGTRLPWdeeWIIESLSD-----StiymayytIAHKIREYGIKPEQLTPEFFDYVFL---- 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 513 GKAPLRRVSEvfdcwfESGsMPYAQVHypfESKREFEDAFPADFIAEGIDqtrgwfytlLV---LA------TALFGQ-- 581
Cdd:PRK12300 500 GKGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAIFPEek 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 582 -PpfKNVIVNGLILaSDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVLKDvll 654
Cdd:PRK12300 561 wP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQLER--- 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 655 pWYNayrfFIQNVFRLHKEEEVKFLynehtvrespnitDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLvkFVDILT--N 732
Cdd:PRK12300 631 -FYE----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYELLNdlR 690
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 733 WYVRMnrrrlkgesGVEDCVMALETLFSVLLslcRLMAPYTPFLTELMYQNLKllidpaslrDKDTLSIhyLMLPRVREE 812
Cdd:PRK12300 691 WYLRR---------VGEANNKVLREVLEIWI---RLLAPFTPHLAEELWHKLG---------GEGFVSL--EKWPEPDES 747
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 813 LIDKKTENAVSRMQSVIelgrvirdrktipikyplkeivvihqdpealEDIRSLEKYIieELNVRKVTLST-DKNKYGIr 891
Cdd:PRK12300 748 KIDEEAELAEEYVKRLI-------------------------------EDIREILKVA--KIKPKKVYIYVaPDWKYEV- 793
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 254553372 892 LRAEPDHMVLGKRLKGAFKAVMMaiKRLSNEELERFQKsgsIVVEGHELHEEDIRLMYT 950
Cdd:PRK12300 794 LEIAAENGDVKEAIKELMKDEEL--RKHGKEVAKLAQK---IVKEVLKLDKEVRKLILK 847
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-178 |
5.54e-37 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 142.17 E-value: 5.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 40 KFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVakmgIAEYNKQ 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 254553372 120 CRAIVMRYSAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKV 178
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-836 |
4.86e-30 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 129.25 E-value: 4.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 4 QVPENISFPAEEEKILEFWSKHNCFQECLKQSKlrPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRF 83
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 84 GWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQcraiVMRYSAEWKSTV----TRLGRWIDFDNDYKTLYPQFMESV 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSE----VWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 160 WWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFESNqnYKDVQDPS--------------VFVTF--PLEEDENTSLVAw 223
Cdd:PLN02381 249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVD--YIDIKERTllkvpgydkpvefgVLTSFayPLEGGLGEIVVA- 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 224 TTTPWTLPSNLALCVNPEiqyvkikdvargklfiltEARLSALYKqesdyeileRFPGASLKGKKYKPLFDyfikckeng 303
Cdd:PLN02381 326 TTRIETMLGDTAIAIHPD------------------DERYKHLHG---------KFAVHPFNGRKLPIICD--------- 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 304 afTVLVDHYVkdeeGTGVVHQAPYFGADDHRV----CMDF-NIIQKDSvpvcPVDASGCfteevTHFVGQYVKDADKNII 378
Cdd:PLN02381 370 --AILVDPNF----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNGG-----SEFAGMPRFAAREAVI 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 379 RMLKEQGRLLAAGTFTHSYPFCWRSD---TPLIYksvPSWFVRVEPMVDQLL------KNNDLCYWVPEFVREKRfgNWL 449
Cdd:PLN02381 435 EALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALdaaidgENKKLEFIPKQYLAEWK--RWL 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 450 KEARDWAISRNRYWGTPIPLW---VSEDLEEVVCIGS----VAELEE---------LSGTKIsDLHREsidhltipsrcg 513
Cdd:PLN02381 510 ENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNESdalleasqkFPGKKF-ELSQD------------ 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 514 kaplrrvSEVFDCWFESGSMPYAQVHYPfESKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLI 593
Cdd:PLN02381 577 -------PDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMI 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 594 LASDGQKMSKRKKNYPDPVSIID-------------------------------------KYGADALRLYLInSPVVRAE 636
Cdd:PLN02381 649 RDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALV-SYTAQSD 727
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 637 NLRFkeegvrDVLKDV-LLPW----YNAYRFFIQNvfrlhkeeevkfLYNEHTVRESPNITD-----RWVLSFMQSLLGF 706
Cdd:PLN02381 728 KINL------DILRVVgYRQWcnklWNAVRFAMSK------------LGDDYTPPATLSVETmpfscKWILSVLNKAISK 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 707 FETEMAAYRLYTVVPRLVK---------FVDILTNWYVRMNRRRLKGESGVEDcvmaleTLFSVLLSLCRLMAPYTPFLT 777
Cdd:PLN02381 790 TVSSLDAYEFSDAASTVYSwwqyqfcdvFIEAIKPYFAGDNPEFASERAAAQD------TLWICLDTGLRLLHPFMPFVT 863
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 254553372 778 ELMYQNLkllidPASLRDKDTLSIHYLMLPRVREELIDKKTENAVSRMQSVIELGRVIR 836
Cdd:PLN02381 864 EELWQRL-----PQPKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLR 917
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
693-851 |
1.24e-22 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 95.16 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 693 DRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGESGVEdcvMALETLFSVLLSLCRLMAP 771
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 772 YTPFLTELMYQNlkllidpaslrdkdtLSIHYLMLPrVREELIDKKTENAVSRMQSVIELGRVIRDRKTIPIKYPLKEIV 851
Cdd:pfam08264 78 FMPFITEELWQK---------------ESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-626 |
2.32e-21 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 101.05 E-value: 2.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 3 QQVPENISFPAEEEKILEFWSKHNCFQ--ECLKQSKlrPKFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHV 79
Cdd:PLN02563 74 PAAKRAYPFHEIEPKWQRYWEENRTFRtpDDVDTSK--PKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 80 DRRFGWDCHGLPVE-YEIDKtlGIKgPEDVAKMGIAEYNKQCRAIVMRYsaewkstvtrlgrwiDFDNDYKTLYPQFMES 158
Cdd:PLN02563 152 LHPMGWDAFGLPAEqYAIET--GTH-PKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEPEYYKW 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 159 VWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFE-----SNQN------------------YKD--VQD------PSVF 207
Cdd:PLN02563 214 TQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglSERGghpvirkpmrqwmlkitaYADrlLEDlddldwPESI 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 208 ---------------VTFPL-----EEDENTSLVaWTTTPWTLPSNLALCVNPEIQYVkikdvarGKLFILTEARLSALY 267
Cdd:PLN02563 294 kemqrnwigrsegaeLDFSVldgegKERDEKITV-YTTRPDTLFGATYLVVAPEHPLL-------SSLTTAEQKEAVEEY 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 268 KQ----ESDyeiLERfpgASLKGKKYKPLFDYFIKCKENG-AFTVLVDHYVKDEEGTGVVHQAPyfgADDHRvcmDFNII 342
Cdd:PLN02563 366 VDaasrKSD---LER---TELQKEKTGVFTGSYAINPATGeAIPIWVADYVLGSYGTGAIMAVP---AHDTR---DFEFA 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 343 QKDSVPVCPV---------DASGCFTEEVT---------HFVGQYVKDADKNIIRMLKEQGrllaAGTFTHSYPFcwrsd 404
Cdd:PLN02563 434 QKFDLPIKWVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIEWLEETG----NGKKKVNYKL----- 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 405 tpliyksvpswfvrvepmvdqllknndlcywvpefvrekrfgnwlkeaRDWAISRNRYWGTPIPLWVSEDLEEVVCIG-- 482
Cdd:PLN02563 505 ------------------------------------------------RDWLFARQRYWGEPIPVVFLEDSGEPVPVPes 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 483 ----SVAELEEL--SGTKISDLHRESIDHLTIPSRCGKaPLRRvsevfdcwfESGSMP--------YAQVHYPFESKREF 548
Cdd:PLN02563 537 dlplTLPELDDFtpTGTGEPPLAKAVSWVNTVDPSSGK-PARR---------ETNTMPqwagscwyYLRFMDPKNSNALV 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 549 -----EDAFPADFIAEGIDQ-------TRGW---FYTLLVLATalfgQPPFKNVIVNGLILA---------SDGQ----- 599
Cdd:PLN02563 607 dkekeKYWMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSDGEyvsad 682
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254553372 600 ----------------------------------------KMSKRKKNYPDPVSIIDKYGADALRLY 626
Cdd:PLN02563 683 tadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY 749
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
861-1033 |
2.11e-20 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 90.61 E-value: 2.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 861 EDIrslekyIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMMAIKRLSNEELERFQKSGS--IVVEGH 938
Cdd:pfam19302 1 EDI------IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 939 --ELHEEDIRLmytfdQATGgTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYNAK 1016
Cdd:pfam19302 74 eiELTSEDLLV-----TRQG-KEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGN 147
|
170
....*....|....*..
gi 254553372 1017 SEgryLNNVIESHTDFI 1033
Cdd:pfam19302 148 EM---LEAAIEKFEDYI 161
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
453-784 |
9.57e-18 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 88.95 E-value: 9.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 453 RDWAISRNRYWGTPIPLWVSEDleevvCiGSVA-----------ELEELSGTKISDLHR-ESIDHLTIPsRCGKaPLRRV 520
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLARaPEWVNVTCP-KCGG-PARRE 491
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 521 SEVFDCWFESgS---MPYAQVHYpfeskrefeDAFPADFIAE----GIDQ--------------TRgwFYTLLVLATALF 579
Cdd:COG0495 492 TDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTKVLRDLGLV 559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 580 GQP-PFKNVIVNGLI--LASDG------QKMSKRKKNYPDPVSIIDKYGADALRLYLI-NSPVVRaeNLRFKEEGVRdvl 649
Cdd:COG0495 560 SFDePFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLEWSDSGVE--- 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 650 kdvllpwyNAYRfFIQNVFRlhkeeevkfLYNEHTVRESPNIT-----DRWVLSFMQSLLGFFETEMAAYRLYTVVPRLV 724
Cdd:COG0495 635 --------GAYR-FLNRVWR---------LVVDEAEALKLDVAdlseaDKELRRALHKTIKKVTEDIERLRFNTAIAALM 696
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254553372 725 KFVDILTnwyvrmnrrRLKGESGVEDCVM--ALETlfsvllsLCRLMAPYTPFLTELMYQNL 784
Cdd:COG0495 697 ELVNALY---------KAKDSGEADRAVLreALET-------LVLLLAPFAPHIAEELWERL 742
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
657-784 |
5.68e-15 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 72.97 E-value: 5.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 657 YNAYRFFIQNvfrlhkeEEVKFLYNEHTVRESPniTDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 735
Cdd:cd07962 17 WNAARFVLMN-------LEDDDEPEEDPESLSL--ADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 254553372 736 RMNRRRLKGESGVEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:cd07962 88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-175 |
1.20e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 73.44 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKtLGIKgPEDvakmgIAEYNkqcraivmry 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK-IGRD-PED-----WTEYN---------- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 254553372 128 SAEWKSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRG 175
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
424-628 |
1.82e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.97 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 424 DQLLKN-NDLCYWvPEFVReKRFGNWLkeardwAISRNRYWGTPIPlWvsEDLeevvcigsvaeLEELSGTKISDLhRES 502
Cdd:cd00812 143 EKLLKDlEKLDGW-PEEVR-AMQENWI------GCSRQRYWGTPIP-W--TDT-----------MESLSDSTWYYA-RYT 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 503 IDHLTipsrcgKAPLRRVSEvfdcwfesgsmpyaqvhypfESKREFEDAFPADFIAEGIDQ-----TRGWFYTLLVLATA 577
Cdd:cd00812 200 DAHNL------EQPYEGDLE--------------------FDREEFEYWYPVDIYIGGKEHapnhlLYSRFNHKALFDEG 253
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 254553372 578 LFGQPPFKNVIVNGLILAsDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI 628
Cdd:cd00812 254 LVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
48-628 |
3.70e-12 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 70.53 E-value: 3.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIKGpedvAKMGIAEynkqcRAIVM 125
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIE--------LAA----EKEGITP-----QELVD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 126 RYSAEWKSTVTRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACgtplsnfesnqnykdvqdps 205
Cdd:COG0143 71 RIHAEFKELFEKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPEC-------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 206 vfvtfpleedentslvawtttpwtlpsnlalcvnpeiqyvkikdvargklfiltearlsalykqesdyeilERFpgaslk 285
Cdd:COG0143 129 -----------------------------------------------------------------------ERF------ 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 286 gkkykpLFDYFIkckengaftvlvdhyvkdeEGTgvvhqAPYFGADDHRvcmdfniiqKDSVPVCpvdasgcfteevthf 365
Cdd:COG0143 132 ------LPDRYV-------------------EGT-----CPKCGAEDAY---------GDQCENC--------------- 157
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 366 vgqyvkdadkniirmlkeqGRLLAAGTFTHsyPFCWRSDTPLIYKSVPSWFVRVEPMVDQLLK----NNDlcyWVPEFVR 441
Cdd:COG0143 158 -------------------GATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLEwieeNPD---IQPEVRN 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 442 EKRfgNWLKEA-RDWAISRNRYWGTPIPlwvsedleevvcigsvaeleelsGTKisdlhresiDHltipsrcgkaplrrv 520
Cdd:COG0143 214 EVL--SWLKEGlQDLSISRDFDWGIPVP-----------------------GDP---------GK--------------- 244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 521 seVFDCWFE------SGSMPYAQVHYPFEskrEFEDAFPAD------FIaeGIDQTRgwFYTLL---VLATAlfGQPPFK 585
Cdd:COG0143 245 --VFYVWFDaligyiSATKGYADDRGLPE---DFEKYWPAPdtelvhFI--GKDIIR--FHAIIwpaMLMAA--GLPLPK 313
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 254553372 586 NVIVNGLILaSDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI 628
Cdd:COG0143 314 KVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLL 355
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-190 |
1.05e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 65.00 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEYEIDKtLGIkGPEDVakmgiaeynkqcraiVM 125
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEK-EGI-TPEEL---------------VD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254553372 126 RYSAEWKSTVTRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLS 190
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
359-628 |
1.70e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 63.70 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 359 TEEVTHfvgqyvKDADKNIIRMLKEQGRLlaagtFTHSY--PFCWRSDTPL-IYKSVPSWFVRVEPMVDQL---LKNNDL 432
Cdd:cd00814 92 TTSPRH------KEIVQEFFKKLYENGYI-----YEGEYegLYCVSCERFLpEWREEEHYFFRLSKFQDRLlewLEKNPD 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 433 CYWVPEFVREKRfgNWLKEA-RDWAISR-NRYWGTPIPL--------WVseDleevvcigsvAELEELSGTKisdlhres 502
Cdd:cd00814 161 FIWPENARNEVL--SWLKEGlKDLSITRdLFDWGIPVPLdpgkviyvWF--D----------ALIGYISATG-------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 503 idhltipsrcgkaplrrvsevfdCWFEsgsmpyaqvhyPFESKREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLATA 577
Cdd:cd00814 219 -----------------------YYNE-----------EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 254553372 578 lfGQPPFKNVIVNGLILAsDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI 628
Cdd:cd00814 261 --GLPLPTRIVAHGYLTV-EGKKMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
398-628 |
4.08e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 60.67 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 398 PFCWRSDTPLIYKSVPSWFVRVEPMVDQLLK---NNdlcywvPEFV----REKRFGNWLKE-ARDWAISRNRY-WGTPIP 468
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLElyeAN------PDFIqpasRRNEVISFVKSgLKDLSISRTNFdWGIPVP 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 469 lwvsEDLEEVVcigSVaeleelsgtkisdlhresidhltipsrcgkaplrrvsevfdcWF------ESGSM-PYAQVhyp 541
Cdd:PRK11893 216 ----GDPKHVI---YV------------------------------------------WFdaltnyLTALGyPDDEE--- 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 542 fESKREFEDAFPAD--FIaeGIDQTR----GWfytlLVLATALfGQPPFKNVIVNGLILaSDGQKMSKRKKNYPDPVSII 615
Cdd:PRK11893 244 -LLAELFNKYWPADvhLI--GKDILRfhavYW----PAFLMAA-GLPLPKRVFAHGFLT-LDGEKMSKSLGNVIDPFDLV 314
|
250
....*....|...
gi 254553372 616 DKYGADALRLYLI 628
Cdd:PRK11893 315 DEYGVDAVRYFLL 327
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
540-628 |
2.42e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 58.27 E-value: 2.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 540 YPFESKREFEDAFPADFIAEGIDQTRgwFYT------LLVLatalfGQPPFKNVIVNGLILAsDGQKMSKRKKNYPDPVS 613
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
|
90
....*....|....*
gi 254553372 614 IIDKYGADALRLYLI 628
Cdd:PRK12267 313 LVDRYGLDALRYYLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
657-773 |
1.78e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 50.97 E-value: 1.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 657 YNAYRFFIQNVFrlhkeeevkfLYNEHTVRESPNITDRWVLSFMQSLLGFFETEMAAYRLYTVVPRLVKFVDILtNWYVR 736
Cdd:cd07375 15 YRLLSFFRKALG----------GTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLD 83
|
90 100 110
....*....|....*....|....*....|....*..
gi 254553372 737 MNRRRLKGESGVEDCVMALETLFSVLLslcRLMAPYT 773
Cdd:cd07375 84 ELKPALQTEELREAVLAVLRAALVVLT---KLLAPFT 117
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
693-831 |
8.12e-07 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 50.60 E-value: 8.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 693 DRWVLS----FMQSLLGFFETemaaYRLYTVVPRLVKFV-DILTNWYV-----RM-------NRRRlkgesgvedcvMAL 755
Cdd:cd07960 46 DRYALHrlneLIKEVREAYEN----YEFHKVYQALNNFCtVDLSAFYLdiikdRLycdakdsLERR-----------SAQ 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254553372 756 ETLFSVLLSLCRLMAPYTPFLTELMYQNLkllidPASLRDKdtlSIHYLMLPRVREELIDKKTENavsRMQSVIEL 831
Cdd:cd07960 111 TVLYHILDALLKLLAPILPFTAEEVWEHL-----PGEKKEE---SVFLEDWPELPEEWKDEELEE---KWEKLLAL 175
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
47-187 |
8.24e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 46.80 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 47 PPFATGLPHYGHilAGT--IKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidKTlgikgpedvAKmgiaEYNKQCRA 122
Cdd:PRK11893 9 IYYPNGKPHIGH--AYTtlAADVLARFKRLRGYDV--FFltGTDEHGQKIQ----RK---------AE----EAGISPQE 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254553372 123 IVMRYSAEWKSTVTRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGT 187
Cdd:PRK11893 68 LADRNSAAFKRLWEALN--ISYDDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEE 130
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
572-630 |
1.04e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 41.80 E-value: 1.04e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 254553372 572 LVLATALFGQPPFKNVIVNGLILAsDGQKMSKRKKNYPDPVSIIDKYGADALRLYLINS 630
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
48-174 |
1.36e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.83 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254553372 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIKGpedvAKMGIAEynkqcRAIVM 125
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEV--LFvcADDAHGTPIM--------LKA----EKEGITP-----EELIA 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 254553372 126 RYSAEWKSTVTRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYR 174
Cdd:PRK00133 72 RYHAEHKRDFAGFG--ISFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
576-650 |
2.26e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 41.58 E-value: 2.26e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254553372 576 TALFGQPPFKNVIVNGLILAsDGQKMSKRKKNYPDPVSIIDKYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 650
Cdd:pfam01406 230 EAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
|
|
| |
