NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24655069|ref|NP_725798|]
View 

uncharacterized protein Dmel_CG30116, isoform D [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
991-1491 1.64e-65

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 1.64e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  991 AAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQ-MTSA 1069
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1070 VLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPP 1149
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1150 NPGPVTAVhamdnddflvtvggnkitfySFrneelyvnpysrhprrkrslkrhaqaqrspsttlppitcfdlSRDSQQMA 1229
Cdd:COG2319  161 HSGAVTSV--------------------AF------------------------------------------SPDGKLLA 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1230 IASGRH-VHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDS 1308
Cdd:COG2319  179 SGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1309 LRVISTDRDSMLLVWMAHSGNLLQTIQGpykslsvtnnmrfavstngdntlkiwsltqedekysvsHSDEITCFEISADS 1388
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTG--------------------------------------HSGGVNSVAFSPDG 300

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1389 VHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVK 1468
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                        490       500
                 ....*....|....*....|...
gi 24655069 1469 VSADGSTAVSGSDDKTLIVWETK 1491
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
897-1057 8.14e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 8.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  897 TGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLRERR 976
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  977 AHIKnAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLD 1056
Cdd:COG2319  324 RTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                 .
gi 24655069 1057 N 1057
Cdd:COG2319  403 T 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
991-1491 1.64e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 1.64e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  991 AAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQ-MTSA 1069
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1070 VLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPP 1149
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1150 NPGPVTAVhamdnddflvtvggnkitfySFrneelyvnpysrhprrkrslkrhaqaqrspsttlppitcfdlSRDSQQMA 1229
Cdd:COG2319  161 HSGAVTSV--------------------AF------------------------------------------SPDGKLLA 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1230 IASGRH-VHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDS 1308
Cdd:COG2319  179 SGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1309 LRVISTDRDSMLLVWMAHSGNLLQTIQGpykslsvtnnmrfavstngdntlkiwsltqedekysvsHSDEITCFEISADS 1388
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTG--------------------------------------HSGGVNSVAFSPDG 300

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1389 VHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVK 1468
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                        490       500
                 ....*....|....*....|...
gi 24655069 1469 VSADGSTAVSGSDDKTLIVWETK 1491
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1248-1502 9.85e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.49  E-value: 9.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1248 CTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHS 1327
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1328 GNLLQTIQG---PYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSV-SHSDEITCFEISADSVHIISGSRDMSLKVW 1403
Cdd:cd00200   83 GECVRTLTGhtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1404 QATGGKLSQVLVGHSDAVTCVAVSvTNKTQVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDK 1483
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                        250
                 ....*....|....*....
gi 24655069 1484 TLIVWETKRGLALTSLQMH 1502
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGH 260
WD40 COG2319
WD40 repeat [General function prediction only];
897-1057 8.14e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 8.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  897 TGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLRERR 976
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  977 AHIKnAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLD 1056
Cdd:COG2319  324 RTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                 .
gi 24655069 1057 N 1057
Cdd:COG2319  403 T 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1243-1282 9.57e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 9.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1243 TPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWN 1282
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1249-1282 1.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.71e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24655069   1249 TLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWN 1282
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 1239-1515 2.72e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1239 MRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNlalgeiCNSfkghtapvvkvvvlmdslrVISTDRD- 1317
Cdd:PLN00181  468 LRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFE------CES-------------------IIKDGRDi 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1318 SMLLVWMAHSGNLLQTIQGPYKSLSVTnnmrfavSTNGDNTLKIWSLT--------QEDEK--YSVSHSdeitcfeiSAD 1387
Cdd:PLN00181  523 HYPVVELASRSKLSGICWNSYIKSQVA-------SSNFEGVVQVWDVArsqlvtemKEHEKrvWSIDYS--------SAD 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1388 SVHIISGSRDMSLKVWQATGGkLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDLLTGE-EVHTLAGHLGPVIG 1466
Cdd:PLN00181  588 PTLLASGSDDGSVKLWSINQG-VSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSY 666

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24655069  1467 VKVsADGSTAVSGSDDKTLIVWETKRGLA------LTSLQMHVPFTHFdISLEVS 1515
Cdd:PLN00181  667 VRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNF-VGLSVS 719
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 928-969 3.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 3.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 24655069     928 SNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWH 969
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
933-968 7.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 7.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24655069    933 HIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVW 968
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
991-1491 1.64e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 1.64e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  991 AAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQ-MTSA 1069
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1070 VLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPP 1149
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1150 NPGPVTAVhamdnddflvtvggnkitfySFrneelyvnpysrhprrkrslkrhaqaqrspsttlppitcfdlSRDSQQMA 1229
Cdd:COG2319  161 HSGAVTSV--------------------AF------------------------------------------SPDGKLLA 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1230 IASGRH-VHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDS 1308
Cdd:COG2319  179 SGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1309 LRVISTDRDSMLLVWMAHSGNLLQTIQGpykslsvtnnmrfavstngdntlkiwsltqedekysvsHSDEITCFEISADS 1388
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTG--------------------------------------HSGGVNSVAFSPDG 300

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1389 VHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVK 1468
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                        490       500
                 ....*....|....*....|...
gi 24655069 1469 VSADGSTAVSGSDDKTLIVWETK 1491
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1190-1502 1.34e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.00  E-value: 1.34e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1190 SRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRDSQQMAIASGRH-VHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEF 1268
Cdd:COG2319   55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGtVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1269 LATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQGPYK---SLSVTN 1345
Cdd:COG2319  135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavrSVAFSP 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1346 NMRFAVSTNGDNTLKIWSLTQEDEKYSVS-HSDEITCFEISADSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCV 1424
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655069 1425 AVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQMH 1502
Cdd:COG2319  295 AFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1248-1502 9.85e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.49  E-value: 9.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1248 CTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHS 1327
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1328 GNLLQTIQG---PYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEKYSV-SHSDEITCFEISADSVHIISGSRDMSLKVW 1403
Cdd:cd00200   83 GECVRTLTGhtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1404 QATGGKLSQVLVGHSDAVTCVAVSvTNKTQVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDK 1483
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                        250
                 ....*....|....*....
gi 24655069 1484 TLIVWETKRGLALTSLQMH 1502
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGH 260
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1215-1489 2.52e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.56  E-value: 2.52e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1215 PITCFDLSRDSQQMAIASG-RHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALGEICNSFK 1293
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1294 GHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQG---PYKSLSVTNNMRFAVSTNGDNTLKIWSLTQEDEK 1370
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1371 YS-VSHSDEITCFEISADSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLL 1449
Cdd:cd00200  171 ATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLR 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 24655069 1450 TGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWE 1489
Cdd:cd00200  250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
822-1284 6.17e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 6.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  822 SSDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWLPAPLPSQIRTMTVSGTGCIR 901
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  902 AVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLRERRAHIKn 981
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DGKTLASGSADGTVRLWDLATGKLLRTLT- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  982 AHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLL 1061
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1062 NTMQM-TSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHA 1140
Cdd:COG2319  240 RTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1141 GKLVRSLPPNPGPVTAVhamdnddflvtvggnkitfysfrneelyvnpysrhprrkrslkrhaqaqrspsttlppitcfD 1220
Cdd:COG2319  320 GKLLRTLTGHTGAVRSV--------------------------------------------------------------A 337

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24655069 1221 LSRDSQQMAIASG-RHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLA 1284
Cdd:COG2319  338 FSPDGKTLASGSDdGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1190-1503 8.72e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 8.72e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1190 SRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLSRDSQQMAIASGRHVHLMRINTPEYQCTLEGHTAGVSCLKFAPNGEFL 1269
Cdd:COG2319   14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1270 ATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQG---PYKSLSVTNN 1346
Cdd:COG2319   94 ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhsgAVTSVAFSPD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1347 MRFAVSTNGDNTLKIWSLTQEDEKYSVS-HSDEITCFEISADSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVA 1425
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24655069 1426 VSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQMHV 1503
Cdd:COG2319  254 FSPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 933-1282 1.39e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 1.39e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  933 HIFKGHTAAVTCllVAPQSDSELLLTGSEDATVLVWHVGLRERRAHIKNaHTAPITGVAAGANNTLIISSSEDASIAITD 1012
Cdd:cd00200    3 RTLKGHTGGVTC--VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1013 LASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLNTMQM-TSAVLRIDISWNSVFLLALCEDNAL 1091
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1092 YVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGG 1171
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1172 NkitfysfrneelyvnpysrhprrkrslkrhaqaqrspsttlppitcfdlsrdsqqmaiasgRHVHLMRINTPEYQCTLE 1251
Cdd:cd00200  240 D-------------------------------------------------------------GTIRVWDLRTGECVQTLS 258

                        330       340       350
                 ....*....|....*....|....*....|.
gi 24655069 1252 GHTAGVSCLKFAPNGEFLATGSEDRLVHIWN 1282
Cdd:cd00200  259 GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
820-1173 1.08e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 1.08e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  820 RKSSDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSM--TVRSATAWCDGyAVPLLVPLTGWLPAPLPSQirtmtvsgT 897
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdGRLLASASADG-TVRLWDLATGLLLRTLTGH--------T 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  898 GCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLRERRA 977
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLATGKLLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  978 HIKnAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDN 1057
Cdd:COG2319  199 TLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1058 FTLLNTMQM-TSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIY 1136
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 24655069 1137 DMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGNK 1173
Cdd:COG2319  358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
1262-1502 2.60e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 2.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1262 FAPNGEFLATGSEDRLVHIWNLALGEICNSFKGHTAPVVKVVVLMDSLRVISTDRDSMLLVWMAHSGNLLQTIQG---PY 1338
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGhtaAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1339 KSLSVTNNMRFAVSTNGDNTLKIWSL-TQEDEKYSVSHSDEITCFEISADSVHIISGSRDMSLKVWQATGGKLSQVLVGH 1417
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLaTGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1418 SDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALT 1497
Cdd:COG2319  162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240


                 ....*
gi 24655069 1498 SLQMH 1502
Cdd:COG2319  241 TLTGH 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 897-1137 1.31e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 1.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  897 TGCIRAV-WLAPSKQhliLATSSGD--VQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLR 973
Cdd:cd00200   51 TGPVRDVaASADGTY---LASGSSDktIRLWDLETGECVRTLTGHTSYVSSVAFSP--DGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  974 ERRAHIKnAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVW 1053
Cdd:cd00200  126 KCLTTLR-GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1054 DLDNFTLLNTMQ-MTSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTR 1132
Cdd:cd00200  205 DLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 24655069 1133 ALIYD 1137
Cdd:cd00200  285 IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 905-1174 2.78e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.08  E-value: 2.78e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  905 LAPSKQHLILATSSGD--VQQWHIMSNSLDHIFKGHTAAVTCllVAPQSDSELLLTGSEDATVLVWHVGLRERRAHIKnA 982
Cdd:cd00200   15 VAFSPDGKLLATGSGDgtIKVWDLETGELLRTLKGHTGPVRD--VAASADGTYLASGSSDKTIRLWDLETGECVRTLT-G 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  983 HTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNFTLLN 1062
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1063 TMQM-TSAVLRIDISWNSVFLLALCEDNALYVRTLATGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAG 1141
Cdd:cd00200  172 TLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                        250       260       270
                 ....*....|....*....|....*....|...
gi 24655069 1142 KLVRSLPPNPGPVTAVHAMDNDDFLVTVGGNKI 1174
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
897-1057 8.14e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 8.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  897 TGCIRAVWLAPSKQHLILATSSGDVQQWHIMSNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWHVGLRERR 976
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP--DGKLLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  977 AHIKnAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLD 1056
Cdd:COG2319  324 RTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                 .
gi 24655069 1057 N 1057
Cdd:COG2319  403 T 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1410-1502 6.59e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 6.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1410 LSQVLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWE 1489
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90
                 ....*....|...
gi 24655069 1490 TKRGLALTSLQMH 1502
Cdd:cd00200   80 LETGECVRTLTGH 92
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1243-1282 9.57e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 9.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1243 TPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWN 1282
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1249-1282 1.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.71e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24655069   1249 TLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWN 1282
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1354-1485 7.58e-08

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 56.23  E-value: 7.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069   1354 NGDNTLKIWSLTQEDEKYSVS-HSDEITCFEISADSVHIISGSRDMSLKVWQATGGKLSQ-------------------- 1412
Cdd:pfam20426  101 NWENSFQVISLNDGRMVQSIRqHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaet 180

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24655069   1413 ---VLVGHSDAVTCVAVSVTNKTqVLSGSKDMNLILWDLLTGEEVHTLAGHLG-PVIGVKVSADGSTAVSGSDDKTL 1485
Cdd:pfam20426  181 pfhILCGHDDIITCLYVSVELDI-VISGSKDGTCIFHTLREGRYVRSIRHPSGcPLSKLVASRHGRIVLYADDDLSL 256
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1450-1489 6.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 6.27e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1450 TGEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWE 1489
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1451-1489 5.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 5.39e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24655069   1451 GEEVHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWE 1489
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1408-1447 2.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.58e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1408 GKLSQVLVGHSDAVTCVAVSvTNKTQVLSGSKDMNLILWD 1447
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 1239-1515 2.72e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1239 MRINTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNlalgeiCNSfkghtapvvkvvvlmdslrVISTDRD- 1317
Cdd:PLN00181  468 LRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFE------CES-------------------IIKDGRDi 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1318 SMLLVWMAHSGNLLQTIQGPYKSLSVTnnmrfavSTNGDNTLKIWSLT--------QEDEK--YSVSHSdeitcfeiSAD 1387
Cdd:PLN00181  523 HYPVVELASRSKLSGICWNSYIKSQVA-------SSNFEGVVQVWDVArsqlvtemKEHEKrvWSIDYS--------SAD 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  1388 SVHIISGSRDMSLKVWQATGGkLSQVLVGHSDAVTCVAVSVTNKTQVLSGSKDMNLILWDLLTGE-EVHTLAGHLGPVIG 1466
Cdd:PLN00181  588 PTLLASGSDDGSVKLWSINQG-VSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSY 666

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 24655069  1467 VKVsADGSTAVSGSDDKTLIVWETKRGLA------LTSLQMHVPFTHFdISLEVS 1515
Cdd:PLN00181  667 VRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNF-VGLSVS 719
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 928-969 3.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 3.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 24655069     928 SNSLDHIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVWH 969
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1015-1054 4.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 4.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1015 SGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWD 1054
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 1082-1162 5.12e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.42  E-value: 5.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069   1082 LLALC-EDNALYVRTLaTGKELHTL--KGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLPPNPGPVTAVH 1158
Cdd:pfam12894    9 LIALAtEDGELLLHRL-NWQRVWTLspDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLG 87


                   ....
gi 24655069   1159 AMDN 1162
Cdd:pfam12894   88 WGEN 91
WD40 pfam00400
WD domain, G-beta repeat;
1408-1447 6.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 6.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24655069   1408 GKLSQVLVGHSDAVTCVAVSvTNKTQVLSGSKDMNLILWD 1447
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
933-968 7.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 7.35e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24655069    933 HIFKGHTAAVTCLLVAPqsDSELLLTGSEDATVLVW 968
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1381-1500 1.21e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.22  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069   1381 CF---EISADSVHIISGSRDMSLKVWQATGGKLSQVLVGHSDAVTCVAVSvTNKTQVLSGSKDMNLILWDLLTGEE---- 1453
Cdd:pfam20426   84 CFatlQTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVT-SDGSILATGSYDTTVMVWEVLRGRSsekr 162

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24655069   1454 -------------------VHTLAGHLGPVIGVKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQ 1500
Cdd:pfam20426  163 srntqtefprkdhviaetpFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIR 228
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
959-1172 1.41e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069  959 GSEDATVLVWHVGLRERRAHIKNAHTAPITGVAAGANNTLIISSSEDASIAITDLASGKLRHRITHHRGPvSGIVVAGAc 1038
Cdd:COG3391   43 GVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPD- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069 1039 dvlisgglDRTICVWDLDNftllntmqmtSAVLRIDISWNSVfllalcednalyVRTLATGKELHtlkghkskirSISIG 1118
Cdd:COG3391  121 --------GGRLYVADSGN----------GRVSVIDTATGKV------------VATIPVGAGPH----------GIAVD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 24655069 1119 KDSQRCVVGCDDTRAL-----IYDMHAGKLVRSLPPNPGPVTAVHAMDNDDFLVTVGGN 1172
Cdd:COG3391  161 PDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGS 219
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 938-1035 1.58e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069    938 HTAAVTCLLVApqSDSELLLTGSEDATVLVWHVgLR----ERRA-------------------HIKNAHTAPITGVAAGA 994
Cdd:pfam20426  123 HKDVVSCVAVT--SDGSILATGSYDTTVMVWEV-LRgrssEKRSrntqtefprkdhviaetpfHILCGHDDIITCLYVSV 199

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 24655069    995 NNTLIISSSEDASIAITDLASGKLRHRITHHRG-PVSGIVVA 1035
Cdd:pfam20426  200 ELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGcPLSKLVAS 241
WD40 pfam00400
WD domain, G-beta repeat;
1016-1054 2.34e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24655069   1016 GKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWD 1054
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1098-1137 4.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 4.21e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 24655069    1098 TGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYD 1137
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1099-1137 7.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 7.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24655069   1099 GKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYD 1137
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 996-1190 8.88e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.52  E-value: 8.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069    996 NTLIISSSEDASIAITDLASGKLRHRITHHRGPVSGIVVAGACDVLISGGLDRTICVWDLDNftlLNTMQMTSAVLRIDI 1075
Cdd:pfam20426   94 NFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLR---GRSSEKRSRNTQTEF 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069   1076 SWNSVFLlalcednalyvrtlaTGKELHTLKGHKSKIRSISIGKDSQRCVVGCDDTRALIYDMHAGKLVRSLP-PNPGPV 1154
Cdd:pfam20426  171 PRKDHVI---------------AETPFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRhPSGCPL 235

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 24655069   1155 TAvhamdnddfLVTVGGNKITFYSfrNEELYVNPYS 1190
Cdd:pfam20426  236 SK---------LVASRHGRIVLYA--DDDLSLHLYS 260
WD40 pfam00400
WD domain, G-beta repeat;
1375-1403 1.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.06e-03
                           10        20
                   ....*....|....*....|....*....
gi 24655069   1375 HSDEITCFEISADSVHIISGSRDMSLKVW 1403
Cdd:pfam00400   10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1375-1403 1.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.84e-03
                            10        20
                    ....*....|....*....|....*....
gi 24655069    1375 HSDEITCFEISADSVHIISGSRDMSLKVW 1403
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 1004-1144 3.12e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 41.23  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24655069   1004 EDASIAITDLASGKLRHRITHHRGPVSGIVVAGacDVLISGGLDRTICVWDLDNFTLLNTMQMTSAVLRI-DISWNSVFL 1082
Cdd:pfam13360    1 ADGVVTALDAATGAELWRVDLETGLGGGVAVDG--GRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGApLVAGGRVFV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24655069   1083 LAlcEDNALYVRTLATGKELHTLKGHKSKIRSISIG---KDSQRCVVGCDDTRALIYDMHAGKLV 1144
Cdd:pfam13360   79 VA--GDGSLIALDAADGRRLWSYQRSGEPLALRSSGspaVVGDTVVAGFSSGKLVALDPATGKVR 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH