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Conserved domains on  [gi|24584213|ref|NP_723847|]
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mitochondrial ribosomal protein S23 [Drosophila melanogaster]

Protein Classification

mS23 family ribosomal protein( domain architecture ID 10564645)

mS23 family ribosomal protein such as mammalian mitochondrial 28S ribosomal protein MRPS23

Gene Ontology:  GO:0003735|GO:0006412
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-126 5.19e-63

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


:

Pssm-ID: 463108  Cd Length: 128  Bit Score: 190.93  E-value: 5.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584213     2 AQSRLEKIGTIFTRVQGLLRGGAMKTEDKPIWYDVYAAFPPKLEPRFDRPAPEI--PVRQIFYAEDVVRAKLHKE-NKPQ 78
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKEEEKPLWYDVYEAFPPKREPLYNRPAPRIedPVREIFYEEDVIRAKFYKVyGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24584213    79 ETISLFDHRRSTQSQQFVQIYQDLKGQGALDEQRIYETALDLLAEQRQ 126
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-126 5.19e-63

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 190.93  E-value: 5.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584213     2 AQSRLEKIGTIFTRVQGLLRGGAMKTEDKPIWYDVYAAFPPKLEPRFDRPAPEI--PVRQIFYAEDVVRAKLHKE-NKPQ 78
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKEEEKPLWYDVYEAFPPKREPLYNRPAPRIedPVREIFYEEDVIRAKFYKVyGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24584213    79 ETISLFDHRRSTQSQQFVQIYQDLKGQGALDEQRIYETALDLLAEQRQ 126
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 10-106 2.22e-17

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 73.03  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584213  10 GTIFTRVQGLLRGGAMkteDKPIWYDVYAAFPPKLEPRFDRPapeiPVRQIFYAEDVVRAKLHKENkPQEtislfdhRRS 89
Cdd:cd23701   1 GDLLTRVRKLLRGGVI---EKPLWLDAVERFPPPTPPRRNLG----KPPKITYPEDRLRKKFYKKH-PEE-------AYD 65

                        90
                ....*....|....*..
gi 24584213  90 TQSQQFVQIYQDLKGQG 106
Cdd:cd23701  66 VAEQEFYEERQELEKEQ 82
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-126 5.19e-63

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 190.93  E-value: 5.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584213     2 AQSRLEKIGTIFTRVQGLLRGGAMKTEDKPIWYDVYAAFPPKLEPRFDRPAPEI--PVRQIFYAEDVVRAKLHKE-NKPQ 78
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKEEEKPLWYDVYEAFPPKREPLYNRPAPRIedPVREIFYEEDVIRAKFYKVyGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 24584213    79 ETISLFDHRRSTQSQQFVQIYQDLKGQGALDEQRIYETALDLLAEQRQ 126
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 10-106 2.22e-17

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 73.03  E-value: 2.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584213  10 GTIFTRVQGLLRGGAMkteDKPIWYDVYAAFPPKLEPRFDRPapeiPVRQIFYAEDVVRAKLHKENkPQEtislfdhRRS 89
Cdd:cd23701   1 GDLLTRVRKLLRGGVI---EKPLWLDAVERFPPPTPPRRNLG----KPPKITYPEDRLRKKFYKKH-PEE-------AYD 65

                        90
                ....*....|....*..
gi 24584213  90 TQSQQFVQIYQDLKGQG 106
Cdd:cd23701  66 VAEQEFYEERQELEKEQ 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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