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Conserved domains on  [gi|24581946|ref|NP_723087|]
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uncharacterized protein Dmel_CG31915 [Drosophila melanogaster]

Protein Classification

Glyco_tranf_GTA_type and Glyco_transf_25 domain-containing protein( domain architecture ID 10953614)

Glyco_tranf_GTA_type and Glyco_transf_25 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 334-555 3.15e-42

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 152.08  E-value: 3.15e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 334 RIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLlemgVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWV 413
Cdd:COG3306   2 KIFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEEL----ARYDRAKALRRYGRPLTPGEIGCFLSHRKAWQ 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 414 MMVRKQLKEVLILEDDIRFEPYFRQnavrILNQARN-AAQYDLIYFG-RKRLKEESEPAVENADN--LVHAGYSYW-TLG 488
Cdd:COG3306  78 KIVESGLPYALILEDDVILSPDFAE----VLEALAWlPADWDIVKLEtSKRKVFLGRRKIKKLGGyrLVRPYSPPLgTAG 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581946 489 YVISLQGALKLLA-AKPLDklIPVDEFLplmfdrhpnktwtEAFPKRNLVAFSASPLLLYPIYYTGES 555
Cdd:COG3306 154 YLISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALVIQDSGLLGS 206
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 32-146 6.29e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd04192:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 229  Bit Score: 50.75  E-value: 6.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946  32 VLIAllVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDnsgdlyhsvsyefKPEEQSFVngTSPY 111
Cdd:cd04192   1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQILEFAAA-------------KPNFQLKI--LNNS 63

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24581946 112 EWPASRFKHLIALKEEAFQYgrdiwaDYVFFLDAD 146
Cdd:cd04192  64 RVSISGKKNALTTAIKAAKG------DWIVTTDAD 92
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 334-555 3.15e-42

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 152.08  E-value: 3.15e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 334 RIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLlemgVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWV 413
Cdd:COG3306   2 KIFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEEL----ARYDRAKALRRYGRPLTPGEIGCFLSHRKAWQ 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 414 MMVRKQLKEVLILEDDIRFEPYFRQnavrILNQARN-AAQYDLIYFG-RKRLKEESEPAVENADN--LVHAGYSYW-TLG 488
Cdd:COG3306  78 KIVESGLPYALILEDDVILSPDFAE----VLEALAWlPADWDIVKLEtSKRKVFLGRRKIKKLGGyrLVRPYSPPLgTAG 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581946 489 YVISLQGALKLLA-AKPLDklIPVDEFLplmfdrhpnktwtEAFPKRNLVAFSASPLLLYPIYYTGES 555
Cdd:COG3306 154 YLISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALVIQDSGLLGS 206
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 334-515 5.58e-42

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 147.75  E-value: 5.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 334 RIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLlemgVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWV 413
Cdd:cd06532   1 KIFVINLDRSTDRRERMEAQLAALGLDFEFFDAVDGKDLSEEEL----AALYDALFLPRYGRPLTPGEIGCFLSHYKLWQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 414 MMVRKQLKEVLILEDDIRFEPyfrqnavrilnqarnaaqydliyfgrkrlkeesepavenadnlvhagysYWTLGYVISL 493
Cdd:cd06532  77 KIVESNLEYALILEDDAILDP-------------------------------------------------DGTAGYLVSR 107

                       170       180
                ....*....|....*....|...
gi 24581946 494 QGALKLLAA-KPLDKliPVDEFL 515
Cdd:cd06532 108 KGAKKLLAAlEPIDL--PVDVFL 128
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 335-515 1.29e-32

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 124.47  E-value: 1.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   335 IFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLLEmgvRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWVM 414
Cdd:pfam01755   4 IYVISLKRATERREHIQKEFGKLNIPFQFFDAIDGKELPNHLLFK---LYNFLLRSKYAGRPLTLGEIGCFLSHYSLWQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   415 MVRKQLKEVLILEDDIRFEPYFRQNaVRILNQARNAAQYDLIYFGRKRLKEESEPAVENADNLVHAGYSY---------- 484
Cdd:pfam01755  81 CVELNLEYIIILEDDVILSENFKAI-LQFLLKEINELEFLRLGEWLKTRFDPNDKFIVRLETFLMDSKKFkrtpiadygn 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 24581946   485 -----------WTLGYVISLQGALKLL-AAKPLdkLIPVDEFL 515
Cdd:pfam01755 160 rafyllksghaGTAGYLITPKAAKKLLkYSKNW--PLPVDDLM 200
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 32-146 6.29e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 50.75  E-value: 6.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946  32 VLIAllVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDnsgdlyhsvsyefKPEEQSFVngTSPY 111
Cdd:cd04192   1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQILEFAAA-------------KPNFQLKI--LNNS 63

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24581946 112 EWPASRFKHLIALKEEAFQYgrdiwaDYVFFLDAD 146
Cdd:cd04192  64 RVSISGKKNALTTAIKAAKG------DWIVTTDAD 92
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 5-160 7.39e-07

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 51.28  E-value: 7.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   5 VIFGLLLACILVCISGQDEEDYQESPTVLIALLVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWld 84
Cdd:COG1215   4 LLALLALLYLLLLALARRRRAPADLPRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDETAEIAREL-- 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24581946  85 nsGDLYHSVSYEFKPEEQSFVNgtspyewpasrfkhliALkEEAFQYGRdiwADYVFFLDADVLLtSKDSLKVLTR 160
Cdd:COG1215  82 --AAEYPRVRVIERPENGGKAA----------------AL-NAGLKAAR---GDIVVFLDADTVL-DPDWLRRLVA 134
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 39-158 1.48e-03

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 38.38  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946    39 RNKAHILPMFLSYLEQQDYpkERIAIWlrCDHSNDDSIELLRQWLDnsGDLYHSVSyefkpeeqsfvngtspyEWPASRF 118
Cdd:pfam13704   1 RNEADILPQWLAHHLALGF--DHIYVY--DNGSDDGTAEILARLPD--VSILRSDL-----------------SYKDARF 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24581946   119 KHLI--ALKEEAFqygrdiWADYVFFLDADVLLTSKDSLKVL 158
Cdd:pfam13704  58 QVDWrnALLARYA------EADWVLVVDADEFLVYPPGDRSL 93
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
 334-555 3.15e-42

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 152.08  E-value: 3.15e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 334 RIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLlemgVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWV 413
Cdd:COG3306   2 KIFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEEL----ARYDRAKALRRYGRPLTPGEIGCFLSHRKAWQ 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 414 MMVRKQLKEVLILEDDIRFEPYFRQnavrILNQARN-AAQYDLIYFG-RKRLKEESEPAVENADN--LVHAGYSYW-TLG 488
Cdd:COG3306  78 KIVESGLPYALILEDDVILSPDFAE----VLEALAWlPADWDIVKLEtSKRKVFLGRRKIKKLGGyrLVRPYSPPLgTAG 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581946 489 YVISLQGALKLLA-AKPLDklIPVDEFLplmfdrhpnktwtEAFPKRNLVAFSASPLLLYPIYYTGES 555
Cdd:COG3306 154 YLISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALVIQDSGLLGS 206
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
 334-515 5.58e-42

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 147.75  E-value: 5.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 334 RIFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLlemgVRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWV 413
Cdd:cd06532   1 KIFVINLDRSTDRRERMEAQLAALGLDFEFFDAVDGKDLSEEEL----AALYDALFLPRYGRPLTPGEIGCFLSHYKLWQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946 414 MMVRKQLKEVLILEDDIRFEPyfrqnavrilnqarnaaqydliyfgrkrlkeesepavenadnlvhagysYWTLGYVISL 493
Cdd:cd06532  77 KIVESNLEYALILEDDAILDP-------------------------------------------------DGTAGYLVSR 107

                       170       180
                ....*....|....*....|...
gi 24581946 494 QGALKLLAA-KPLDKliPVDEFL 515
Cdd:cd06532 108 KGAKKLLAAlEPIDL--PVDVFL 128
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
 335-515 1.29e-32

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 124.47  E-value: 1.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   335 IFMINLKRRPERREKMERLFDEIGIEAEHFPAVDGKELSTERLLEmgvRFLPGYEDPYHHRAMTMGEIGCFLSHYNIWVM 414
Cdd:pfam01755   4 IYVISLKRATERREHIQKEFGKLNIPFQFFDAIDGKELPNHLLFK---LYNFLLRSKYAGRPLTLGEIGCFLSHYSLWQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   415 MVRKQLKEVLILEDDIRFEPYFRQNaVRILNQARNAAQYDLIYFGRKRLKEESEPAVENADNLVHAGYSY---------- 484
Cdd:pfam01755  81 CVELNLEYIIILEDDVILSENFKAI-LQFLLKEINELEFLRLGEWLKTRFDPNDKFIVRLETFLMDSKKFkrtpiadygn 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 24581946   485 -----------WTLGYVISLQGALKLL-AAKPLdkLIPVDEFL 515
Cdd:pfam01755 160 rafyllksghaGTAGYLITPKAAKKLLkYSKNW--PLPVDDLM 200
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 32-146 6.29e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 50.75  E-value: 6.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946  32 VLIAllVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWLDnsgdlyhsvsyefKPEEQSFVngTSPY 111
Cdd:cd04192   1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQILEFAAA-------------KPNFQLKI--LNNS 63

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24581946 112 EWPASRFKHLIALKEEAFQYgrdiwaDYVFFLDAD 146
Cdd:cd04192  64 RVSISGKKNALTTAIKAAKG------DWIVTTDAD 92
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 5-160 7.39e-07

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 51.28  E-value: 7.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   5 VIFGLLLACILVCISGQDEEDYQESPTVLIALLVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQWld 84
Cdd:COG1215   4 LLALLALLYLLLLALARRRRAPADLPRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDETAEIAREL-- 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24581946  85 nsGDLYHSVSYEFKPEEQSFVNgtspyewpasrfkhliALkEEAFQYGRdiwADYVFFLDADVLLtSKDSLKVLTR 160
Cdd:COG1215  82 --AAEYPRVRVIERPENGGKAA----------------AL-NAGLKAAR---GDIVVFLDADTVL-DPDWLRRLVA 134
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 5-86 2.49e-04

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 42.95  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946   5 VIFGLLLACILVC---ISGQDEEDYQESPTVLIAllVRNKAHILPMFLSYLEQQDYPKERIAIWLRCDHSNDDSIELLRQ 81
Cdd:cd06439   3 FGYPLLLKLLARLrpkPPSLPDPAYLPTVTIIIP--AYNEEAVIEAKLENLLALDYPRDRLEIIVVSDGSTDGTAEIARE 80


                ....*
gi 24581946  82 WLDNS 86
Cdd:cd06439  81 YADKG 85
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 39-158 1.48e-03

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 38.38  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946    39 RNKAHILPMFLSYLEQQDYpkERIAIWlrCDHSNDDSIELLRQWLDnsGDLYHSVSyefkpeeqsfvngtspyEWPASRF 118
Cdd:pfam13704   1 RNEADILPQWLAHHLALGF--DHIYVY--DNGSDDGTAEILARLPD--VSILRSDL-----------------SYKDARF 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24581946   119 KHLI--ALKEEAFqygrdiWADYVFFLDADVLLTSKDSLKVL 158
Cdd:pfam13704  58 QVDWrnALLARYA------EADWVLVVDADEFLVYPPGDRSL 93
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 34-149 2.53e-03

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 39.03  E-value: 2.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581946  34 IALLVRNKAHILPMFLSYLEQQDYPKERIaiWLRCDHSNDDSIELLRQWLDNsgdlYHSVSYEFKPEEQSfvngtspyew 113
Cdd:cd00761   1 VIIPAYNEEPYLERCLESLLAQTYPNFEV--IVVDDGSTDGTLEILEEYAKK----DPRVIRVINEENQG---------- 64

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24581946 114 pasrfkhLIALKEEAFQYGRdiwADYVFFLDADVLL 149
Cdd:cd00761  65 -------LAAARNAGLKAAR---GEYILFLDADDLL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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