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Conserved domains on  [gi|123317861|ref|NP_722545|]
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germ cell-specific gene 1 protein isoform 2 [Homo sapiens]

Protein Classification

GSG-1 domain-containing protein( domain architecture ID 10544657)

GSG-1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 11-124 2.36e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


:

Pssm-ID: 462270  Cd Length: 109  Bit Score: 206.33  E-value: 2.36e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123317861   11 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 90
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123317861   91 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 124
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 11-124 2.36e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 206.33  E-value: 2.36e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123317861   11 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 90
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123317861   91 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 124
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 11-124 2.36e-67

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 206.33  E-value: 2.36e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123317861   11 SGQRTLLSAILSMLSLSFSTTSLLSNYWFVGTQKVPKPLCEKGLAAKCFDMpvsldGDTNTSTQEVVQYNWETGDDRFSF 90
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGKGKQTNCIDF-----GSSNTSDSEVVQYIWETGDDRFSF 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 123317861   91 RSFRSGMWLSCEETVEEPGERCRSFIELTPPAKR 124
Cdd:pfam07803  76 RYFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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