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Conserved domains on  [gi|300797277|ref|NP_705932|]
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sodium/potassium/calcium exchanger 4 isoform 1 precursor [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 9.63e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 9.63e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   237 LYVFYILIMKYN------VKMQ----------AFFTVKQKSIA--------NGNPVNSELEAGNDFYDGSYDDPSVPLLG 292
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQlsrrpvakvmALGDLSKGDVAeaehtgerTGEEGERPTEAEGENGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   293 QVK-EKPQYGKNPVVMVDE-------------------IMSSSPPKFTFPE--------------------------AGL 326
Cdd:TIGR00927  674 ETKgENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   327 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 401
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   402 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 432
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   433 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 512
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   513 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 592
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797277   593 VLYAIFLCFSIMIE 606
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 9.63e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 9.63e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   237 LYVFYILIMKYN------VKMQ----------AFFTVKQKSIA--------NGNPVNSELEAGNDFYDGSYDDPSVPLLG 292
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQlsrrpvakvmALGDLSKGDVAeaehtgerTGEEGERPTEAEGENGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   293 QVK-EKPQYGKNPVVMVDE-------------------IMSSSPPKFTFPE--------------------------AGL 326
Cdd:TIGR00927  674 ETKgENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   327 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 401
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   402 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 432
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   433 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 512
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   513 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 592
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797277   593 VLYAIFLCFSIMIE 606
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-601 1.87e-34

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 132.56  E-value: 1.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 120 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 200 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMkynvkmqafftvkqksiangnpvnseleagndfy 279
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 280 dgsyddpsvpllgqvkekpqygknpvvmvdeimsssppkftfpeaglrimitnkfgprtrLRMASRiiinerqrlinsan 359
Cdd:COG0530  126 ------------------------------------------------------------IRRARK-------------- 131

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 360 gvssKPLQNGRHENIENGNVPvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcv 439
Cdd:COG0530  132 ----EPAWEEVEEELEEKPKM-------------------------------------------------SLWKALLL-- 156

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 440 tipncskprwekffmvtFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAV 519
Cdd:COG0530  157 -----------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAV 219

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 520 SNTIGSNVFDILVGLGVPWGLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFL 599
Cdd:COG0530  220 GNIIGSNIFNILLVLGIGALITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYL 290


                 ..
gi 300797277 600 CF 601
Cdd:COG0530  291 AL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 2.37e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 104.99  E-value: 2.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  103 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797277  183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 460-595 5.41e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 64.28  E-value: 5.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 460 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 532
Cdd:PRK10734 175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797277 533 GLGVPWGLQTMVVNYGSTVKinsrglVYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 595
Cdd:PRK10734 255 VLGLPALISPGEINPLAFSR------DYWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 80-606 9.63e-119

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 378.95  E-value: 9.63e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277    80 PAIH---EFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFA 156
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   157 SVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLII 236
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   237 LYVFYILIMKYN------VKMQ----------AFFTVKQKSIA--------NGNPVNSELEAGNDFYDGSYDDPSVPLLG 292
Cdd:TIGR00927  594 AYALYVFTMKWNkqielwVKEQlsrrpvakvmALGDLSKGDVAeaehtgerTGEEGERPTEAEGENGEESGGEAEQEGET 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   293 QVK-EKPQYGKNPVVMVDE-------------------IMSSSPPKFTFPE--------------------------AGL 326
Cdd:TIGR00927  674 ETKgENESEGEIPAERKGEqegegeieakeadhkgeteAEEVEHEGETEAEgtedegeietgeegeevedegegeaeGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   327 RIMIT-NKFGPRTRLRMASRIIINERQRLINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPP 401
Cdd:TIGR00927  754 EVETEgDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   402 PEPEPV-----------------------------------------------EADFLSPFSV--PEARGDKVKWVFTWP 432
Cdd:TIGR00927  834 EQELNAenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   433 LIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQ 512
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277   513 GLGDMAVSNTIGSNVFDILVGLGVPWGLQTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVL 592
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          650
                   ....*....|....
gi 300797277   593 VLYAIFLCFSIMIE 606
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 102-598 7.30e-44

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 159.03  E-value: 7.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  102 LHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 181
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  182 LCIIGVCGLFAgQVVRLTWWaVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILimkynvkmqafFTVKQKS 261
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLL-----------FLVKNER 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  262 IANgnpvnseleagndfYDGSYDDpsvpllgQVKEKPQYgknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlr 341
Cdd:TIGR00367 148 WVK--------------YDTYTEE-------NLDENNRR----------------------------------------- 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  342 masriiinerqrlinsangvsskplqngrheniengnvpvenpedpqqnqeqqpppqppppepepveadflspfsvpear 421
Cdd:TIGR00367     --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  422 gdkvkwvftwPLIFllcvtipncskprwekFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVP 501
Cdd:TIGR00367 166 ----------PQIF----------------FSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLP 219

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  502 DCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVnygSTVKINSRGLVYSVVLLLgsvaltVLGIHLNKW 581
Cdd:TIGR00367 220 ELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPV---EPLAYNLDAPVMVIVTLL------LMLFFKTSM 290

                         490
                  ....*....|....*..
gi 300797277  582 RLDRKLGVYVLVLYAIF 598
Cdd:TIGR00367 291 KLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-601 1.87e-34

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 132.56  E-value: 1.87e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 120 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 199
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 200 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMkynvkmqafftvkqksiangnpvnseleagndfy 279
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL---------------------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 280 dgsyddpsvpllgqvkekpqygknpvvmvdeimsssppkftfpeaglrimitnkfgprtrLRMASRiiinerqrlinsan 359
Cdd:COG0530  126 ------------------------------------------------------------IRRARK-------------- 131

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 360 gvssKPLQNGRHENIENGNVPvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcv 439
Cdd:COG0530  132 ----EPAWEEVEEELEEKPKM-------------------------------------------------SLWKALLL-- 156

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 440 tipncskprwekffmvtFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAV 519
Cdd:COG0530  157 -----------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAV 219

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 520 SNTIGSNVFDILVGLGVPWGLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFL 599
Cdd:COG0530  220 GNIIGSNIFNILLVLGIGALITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYL 290


                 ..
gi 300797277 600 CF 601
Cdd:COG0530  291 AL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 103-245 2.37e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 104.99  E-value: 2.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  103 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 182
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797277  183 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 245
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 452-604 5.22e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.84  E-value: 5.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  452 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 531
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797277  532 VGLGVPWGLQTMVVnYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGVYVLVLYAIFLCFSIM 604
Cdd:pfam01699  81 LVLGLSALIGPVKV-DSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-245 5.79e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 96.36  E-value: 5.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  79 DPAIHEFPTDLFSNKERQHGAVLLHILGALymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 158
Cdd:COG0530  132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 159 IGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG-----QVVRLTWWAVcrdsvyyTISVIVLIVFIY-DEQIVWWEGL 232
Cdd:COG0530  208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPipvdpAVLSFDLPVM-------LAATLLLLGLLRtGGRIGRWEGL 280

                        170
                 ....*....|...
gi 300797277 233 VLIILYVFYILIM 245
Cdd:COG0530  281 LLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
482-606 1.07e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 482 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVpwglqTMVVnygSTVKINSRGLVYS 561
Cdd:COG0530   15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGL-----AALI---RPLAVDRRVLRRD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 300797277 562 VVLLLGSVALTVLGIHLNkwRLDRKLGVYVLVLYAIFLCFSIMIE 606
Cdd:COG0530   87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 108-238 1.29e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.98  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  108 LYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAGSSTPELFASVIGVF---ITHGD 167
Cdd:TIGR00845  83 VYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAGD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  168 VGVGTIVGSAVFNILCIIGVCGLF--AGQVVRL----------TWwavcrdSVY-YTISVIVLIVFIYDEQIVwWEGLVL 234
Cdd:TIGR00845 163 LGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtaAW------SVFaYVWLYLILAVFSPGVVEV-WEGLLT 235


                  ....
gi 300797277  235 IILY 238
Cdd:TIGR00845 236 FFFF 239
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 457-603 5.99e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.96  E-value: 5.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  457 FITATLWIAVFSY-IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 535
Cdd:TIGR00367   6 YLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300797277  536 vpwglqtmVVNYGSTVKINSRGLVYSVVLLLGSVALtvLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 603
Cdd:TIGR00367  86 --------LSAIFSPIIVDKDWLRRDILFYLLVSIL--LLFFGLDGQISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 455-573 7.19e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.67  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  455 VTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLG-DMAVSNTIGSNVFDILVG 533
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 300797277  534 LGVPWGLQTMV-VNYGSTVKINSRGLVYSVVLLLGSVALTV 573
Cdd:TIGR00845 837 IGVAWSIAAIYhAANGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 460-595 5.41e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 64.28  E-value: 5.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 460 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 532
Cdd:PRK10734 175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300797277 533 GLGVPWGLQTMVVNYGSTVKinsrglVYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 595
Cdd:PRK10734 255 VLGLPALISPGEINPLAFSR------DYWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 471-605 1.16e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 63.13  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 471 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNygST 550
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH--SD 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 300797277 551 VKINSRGLVYSVVLLLGSValtvlgihLNKWRLDRKLGVYVLVLYAIFLCFSIMI 605
Cdd:PRK10734 100 VLRRELPLMLLVSVLAGSV--------LYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 98-603 3.83e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 62.86  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  98 GAVLLHI-LGALymFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASvIGVFI--THGDVGVGTIV 174
Cdd:PLN03151 139 GYAVLGVwLVAL--FYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 175 GSAVFNILCIIGVCGL-FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQA 253
Cdd:PLN03151 216 GGAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 254 F-FTVKQKSIANGNPVNseleaGNDFYDGSYDDPSV--PLLGQVKEK--PQygknpvvmvdeiMSSSPPKFTFpeaglri 328
Cdd:PLN03151 296 HaRRLKLDVVTPLLPVQ-----GSIFSPSVEEDESMysPLLESDTESdvPR------------LQTSLPQWMW------- 351

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 329 mitnkfgprtrlrmASRIIINERQRLINSANGvSSKPLQNGRHENIENGNvPVENPEDPQQNQEQQPPPQPPPPEPEPVE 408
Cdd:PLN03151 352 --------------ASNVAIYSNHFAKGSVHD-EERPPWGWTDEGAEVES-SLFSCSKLFSLLEMPLTIPRRLTIPIVEE 415

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 409 ADFLSPFSVPEARGDKVKWVFTWP-----------LIFLLCVTI---------PNCSKPRWEKFFMVT-----FITATLW 463
Cdd:PLN03151 416 DRWSKTYAVASASLAPVLLAFLWSsqddvslqariAAYFIGVAIgstlgflayKYTEPDRPPRRFLIPwvlggFIMSIVW 495

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 464 IAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGlGD---MAVSNTIGSNVFDILVGLGVPWGL 540
Cdd:PLN03151 496 FYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLL 574

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797277 541 QTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 603
Cdd:PLN03151 575 GAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 101-245 7.28e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 54.65  E-value: 7.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277 101 LLHILGALYMFYALAIVCDDFFVPSLekicerlhlsedVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 180
Cdd:PRK10734  13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300797277 181 ILCIIGVCGLFAGQVVRLtwwAVCRDSVYYTISVIVLI-VFIYDEQIVWWEGLVLIILYVFYILIM 245
Cdd:PRK10734  81 ILLILGLAALIRPFTVHS---DVLRRELPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 99-192 1.20e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.72  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797277  99 AVLLHILGALYMFYALAIVCDDFFVpslekICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAV 178
Cdd:PRK10734 175 AFLWLGIALIIMPMATRMVIDNATV-----LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNI 249

                         90
                 ....*....|....
gi 300797277 179 FNILCIIGVCGLFA 192
Cdd:PRK10734 250 FNIVIVLGLPALIS 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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