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Conserved domains on  [gi|241982696|ref|NP_700465|]
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aladin [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 2.83e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 316 AQmwTCEAWPTLSGRCQ---TGCWSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGHVGGAKSATIvadlsettiqTPDG 391
Cdd:COG2319  275 LA--TGELLRTLTGHSGgvnSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG 342

                        250       260
                 ....*....|....*....|....*....
gi 241982696 392 eERL--GGEAHSM-VWDPSGERLAVLMKG 417
Cdd:COG2319  343 -KTLasGSDDGTVrLWDLATGELLRTLTG 370
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 2.83e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 316 AQmwTCEAWPTLSGRCQ---TGCWSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGHVGGAKSATIvadlsettiqTPDG 391
Cdd:COG2319  275 LA--TGELLRTLTGHSGgvnSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG 342

                        250       260
                 ....*....|....*....|....*....
gi 241982696 392 eERL--GGEAHSM-VWDPSGERLAVLMKG 417
Cdd:COG2319  343 -KTLasGSDDGTVrLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-413 1.12e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 155 RVFAWHPHTNKFAVALLDDSIRVYNANSTivpSLKHRLQ---RNVAALAWKPLSASVLAVACQSCILIWTLDptslstrp 231
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKghtGPVRDVAASADGTYLASGSSDKTIRLWDLE-------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 232 SSGCAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATTPS 308
Cdd:cd00200   82 TGECVRTLT--GHTsYVSSVAFSPDGRILSSSS-RDKTIKVWDVETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 309 AVFRVWEAQMWTCEAwpTLSG---RCQTGCWSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGH---------------- 368
Cdd:cd00200  157 GTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGHengvnsvafspdgyll 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 241982696 369 VGGAKSATI-VADL-SETTIQTPDGEErlgGEAHSMVWDPSGERLAV 413
Cdd:cd00200  235 ASGSEDGTIrVWDLrTGECVQTLSGHT---NSVTSLAWSPDGKRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.48e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 241982696   237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 1.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 241982696  237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 2.83e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 316 AQmwTCEAWPTLSGRCQ---TGCWSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGHVGGAKSATIvadlsettiqTPDG 391
Cdd:COG2319  275 LA--TGELLRTLTGHSGgvnSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG 342

                        250       260
                 ....*....|....*....|....*....
gi 241982696 392 eERL--GGEAHSM-VWDPSGERLAVLMKG 417
Cdd:COG2319  343 -KTLasGSDDGTVrLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-413 1.12e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 155 RVFAWHPHTNKFAVALLDDSIRVYNANSTivpSLKHRLQ---RNVAALAWKPLSASVLAVACQSCILIWTLDptslstrp 231
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKghtGPVRDVAASADGTYLASGSSDKTIRLWDLE-------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 232 SSGCAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATTPS 308
Cdd:cd00200   82 TGECVRTLT--GHTsYVSSVAFSPDGRILSSSS-RDKTIKVWDVETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 309 AVFRVWEAQMWTCEAwpTLSG---RCQTGCWSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGH---------------- 368
Cdd:cd00200  157 GTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGHengvnsvafspdgyll 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 241982696 369 VGGAKSATI-VADL-SETTIQTPDGEErlgGEAHSMVWDPSGERLAV 413
Cdd:cd00200  235 ASGSEDGTIrVWDLrTGECVQTLSGHT---NSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 4.26e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 4.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 158 AWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPlSASVLAVACQSC-ILIWTLDPTSlstrpssgCA 236
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE--------LL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 237 QVLSHPGHtPVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEA 316
Cdd:COG2319  282 RTLTGHSG-GVNSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                        170       180       190
                 ....*....|....*....|....*....|.
gi 241982696 317 QmwTCEAWPTLSG---RCQTGCWSPDGNRLL 344
Cdd:COG2319  360 A--TGELLRTLTGhtgAVTSVAFSPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
154-413 1.72e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 1.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 154 LRVFAWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSS 233
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--------TG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 234 GCAQVLShpGHT-PVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFR 312
Cdd:COG2319  153 KLLRTLT--GHSgAVTSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 313 VWEAQmwTCEAWPTLSGrcQTGC-----WSPDGNRLLFTVL-GEALIYSLSFPERCGTGKGHVGGAKSATIVAD------ 380
Cdd:COG2319  230 LWDLA--TGKLLRTLTG--HSGSvrsvaFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkllas 305

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 241982696 381 -LSETTIQ---TPDGEERLGGEAH-----SMVWDPSGERLAV 413
Cdd:COG2319  306 gSDDGTVRlwdLATGKLLRTLTGHtgavrSVAFSPDGKTLAS 347
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-380 1.72e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 153 CLRVFAWHPHTNKFAVALLDDSIRVYNANStivPSLKHRL---QRNVAALAWKPLSASVLAVACQSCILIWTLdptslst 229
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLET---GECVRTLtghTSYVSSVAFSPDGRILSSSSRDKTIKVWDV------- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 230 rPSSGCAQVLshPGHT-PVTSLAWAPNGgWLLSASPVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATT 306
Cdd:cd00200  123 -ETGKCLTTL--RGHTdWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVAT--LTGhtGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 241982696 307 PSAVFRVWEAQMWTCEAwpTLSG---RCQTGCWSPDGnRLLFTVLGEALIY--SLSFPERCGTGKGHVGGAKSATIVAD 380
Cdd:cd00200  197 SDGTIKLWDLSTGKCLG--TLRGhenGVNSVAFSPDG-YLLASGSEDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPD 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-315 4.91e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 4.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 133 SLRSEDLIAEFAQVTNWSSCClrvfAWHPhTNKF-AVALLDDSIRVYNANStivPSLKHRL---QRNVAALAWKPLSASV 208
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSV----AFSP-DGTFvASSSQDGTIKLWDLRT---GKCVATLtghTGEVNSVAFSPDGEKL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 209 LAVACQSCILIWTLDPTSlstrpssgCAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG 287
Cdd:cd00200  193 LSSSSDGTIKLWDLSTGK--------CLGTLR--GHEnGVNSVAFSPDGYLLASGS-EDGTIRVWDLRTGECVQT--LSG 259

                        170       180       190
                 ....*....|....*....|....*....|
gi 241982696 288 --GGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:cd00200  260 htNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
158-317 2.60e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 158 AWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPlSASVLAVACQSC-ILIWTLDPTSLstrpssgca 236
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGtVRLWDLATGKL--------- 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 237 qVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  323 -LRTLTGHTgAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 ..
gi 241982696 316 AQ 317
Cdd:COG2319  401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
167-413 8.66e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 8.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 167 AVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDPTSLSTRPssgcaqvlsHPGHTP 246
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---------LGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 247 VTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEAQmwTCEAWPT 326
Cdd:COG2319   81 VLSVAFSPDGRLLASASA-DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 327 LSG---RCQTGCWSPDGnRLLFTVL--GEALIYSLSFPERCGTGKGHVGGAKSA-------TIVADLSETTIQ---TPDG 391
Cdd:COG2319  158 LTGhsgAVTSVAFSPDG-KLLASGSddGTVRLWDLATGKLLRTLTGHTGAVRSVafspdgkLLASGSADGTVRlwdLATG 236

                        250       260
                 ....*....|....*....|....*..
gi 241982696 392 EERL-----GGEAHSMVWDPSGERLAV 413
Cdd:COG2319  237 KLLRtltghSGSVRSVAFSPDGRLLAS 263
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 243-413 7.58e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 7.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 243 GHT-PVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEAQMWTC 321
Cdd:cd00200    7 GHTgGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 322 EAwpTLSGRCQ---TGCWSPDGnRLLFT--VLGEALIYSLSFPERCGTGKGHVGGAKSATI-----------------VA 379
Cdd:cd00200   86 VR--TLTGHTSyvsSVAFSPDG-RILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasssqdgtikLW 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 241982696 380 DL-SETTIQTPDGEErlgGEAHSMVWDPSGERLAV 413
Cdd:cd00200  163 DLrTGKCVATLTGHT---GEVNSVAFSPDGEKLLS 194
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 219-359 6.69e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 49.29  E-value: 6.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 241982696 219 IWTLDPTSLSTRpssgcaQVLSHPGHtpVTSLAWAPNGGWLL--SASPVDAVILVWDVSTETCVPLpWFRGGGVTNLLWS 296
Cdd:COG0823   13 IYVVDLDGGEPR------RLTNSPGI--DTSPAWSPDGRRIAftSDRGGGPQIYVVDADGGEPRRL-TFGGGYNASPSWS 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 241982696 297 PDGSKVL-ATTPSAVFRVW--------EAQMWTCEAWPTlsgrcqtgcWSPDGNRLLFT--VLGEALIYSLSFP 359
Cdd:COG0823   84 PDGKRLAfVSRSDGRFDIYvldldggaPRRLTDGPGSPS---------WSPDGRRIVFSsdRGGRPDLYVVDLD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.48e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 241982696   237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 1.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 241982696  237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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