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Conserved domains on  [gi|23503241|ref|NP_699161|]
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dnaJ homolog subfamily B member 8 [Homo sapiens]

Protein Classification

molecular chaperone DnaJ( domain architecture ID 1000952)

molecular chaperone DnaJ, part of the DnaK-DnaJ-GrpE system, prevents the aggregation of unfolded substrate and acts primarily by stimulating the ATPase activity of Hsp70

CATH:  2.10.230.10
Gene Ontology:  GO:0051082|GO:0005524|GO:0009408|GO:0006457
PubMed:  8016869|15063739|29290615
SCOP:  4003813|4002149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10767 super family cl35946
chaperone protein DnaJ; Provisional
 1-106 3.34e-41

chaperone protein DnaJ; Provisional


The actual alignment was detected with superfamily member PRK10767:

Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 144.13  E-value: 3.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MA--NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDR---AGCDSWRA 75
Cdd:PRK10767   1 MAkrDYYEVLGVSRNASEDEIKKAYRKLAMKYHPDRNPGDK-EAEEKFKEIKEAYEVLSDPQKRAAYDQyghAAFEQGGG 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 23503241   76 GGGAStpyhSPFDTGYTFrnpEDIFREFFGG 106
Cdd:PRK10767  80 GGGFG----GGGGFGDIF---GDIFGDIFGG 103
 
Name Accession Description Interval E-value
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 1-106 3.34e-41

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 144.13  E-value: 3.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MA--NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDR---AGCDSWRA 75
Cdd:PRK10767   1 MAkrDYYEVLGVSRNASEDEIKKAYRKLAMKYHPDRNPGDK-EAEEKFKEIKEAYEVLSDPQKRAAYDQyghAAFEQGGG 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 23503241   76 GGGAStpyhSPFDTGYTFrnpEDIFREFFGG 106
Cdd:PRK10767  80 GGGFG----GGGGFGDIF---GDIFGDIFGG 103
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 4-106 1.32e-39

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 139.27  E-value: 1.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241     4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPY 83
Cdd:TIGR02349   2 YYEILGVSKDASEEEIKKAYRKLAKKYHPDRNKD--KEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGGGGGGG 79

                          90       100
                  ....*....|....*....|...
gi 23503241    84 HSPFDTGYtFRNPEDIFREFFGG 106
Cdd:TIGR02349  80 FNGFDIGF-FGDFGDIFGDFFGG 101
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 3-66 3.54e-36

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 121.81  E-value: 3.54e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23503241     3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYD 66
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRKLALKYHPDKNPGDP-EAEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 3-97 4.33e-36

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 124.43  E-value: 4.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241   3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:COG0484   1 DYYEILGVSRDASAEEIKKAYRKLAKKYHPDRNPGDP-EAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAELLLATELAE 79

                        90
                ....*....|....*
gi 23503241  83 YHSPFDTGYTFRNPE 97
Cdd:COG0484  80 SAAAEAAAAEAKEEA 94
DnaJ smart00271
DnaJ molecular chaperone homology domain;
3-61 1.15e-31

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 110.40  E-value: 1.15e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 23503241      3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKK 61
Cdd:smart00271   2 DYYEILGVPRDASLDEIKKAYRKLALKYHPDKNPGDKEEAEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 3-58 6.90e-29

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 103.01  E-value: 6.90e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23503241   3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNkEEAEKKFKLVSEAYEVLSD 58
Cdd:cd06257   1 DYYDILGVPPDASDEEIKKAYRKLALKYHPDKNPDD-PEAEEKFKEINEAYEVLSD 55
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
3-121 1.01e-25

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 103.75  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGAStp 82
Cdd:NF037946   6 DYYEVLGVDRDADDQEIKKAFRKLAKKYHPDRN--KAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFG-- 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 23503241   83 yhspFDtgytfrnPEDIFREFFGGLDPFSFEFWDSPFNS 121
Cdd:NF037946  82 ----FD-------AFDVFSSFFETINKSGAFLDDSVDES 109
 
Name Accession Description Interval E-value
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 1-106 3.34e-41

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 144.13  E-value: 3.34e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MA--NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDR---AGCDSWRA 75
Cdd:PRK10767   1 MAkrDYYEVLGVSRNASEDEIKKAYRKLAMKYHPDRNPGDK-EAEEKFKEIKEAYEVLSDPQKRAAYDQyghAAFEQGGG 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 23503241   76 GGGAStpyhSPFDTGYTFrnpEDIFREFFGG 106
Cdd:PRK10767  80 GGGFG----GGGGFGDIF---GDIFGDIFGG 103
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 4-106 1.32e-39

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 139.27  E-value: 1.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241     4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPY 83
Cdd:TIGR02349   2 YYEILGVSKDASEEEIKKAYRKLAKKYHPDRNKD--KEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGGGGGGG 79

                          90       100
                  ....*....|....*....|...
gi 23503241    84 HSPFDTGYtFRNPEDIFREFFGG 106
Cdd:TIGR02349  80 FNGFDIGF-FGDFGDIFGDFFGG 101
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 3-66 3.54e-36

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 121.81  E-value: 3.54e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23503241     3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYD 66
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRKLALKYHPDKNPGDP-EAEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 3-97 4.33e-36

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 124.43  E-value: 4.33e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241   3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:COG0484   1 DYYEILGVSRDASAEEIKKAYRKLAKKYHPDRNPGDP-EAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAELLLATELAE 79

                        90
                ....*....|....*
gi 23503241  83 YHSPFDTGYTFRNPE 97
Cdd:COG0484  80 SAAAEAAAAEAKEEA 94
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 3-106 7.88e-32

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 119.27  E-value: 7.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTp 82
Cdd:PRK14290   4 DYYKILGVDRNASQEDIKKAFRELAKKWHPDLHPGNKAEAEEKFKEISEAYEVLSDPQKRRQYDQTGTVDFGAGGSNFN- 82

                         90       100
                 ....*....|....*....|....
gi 23503241   83 yhspFDTGYTFRNPEDIFREFFGG 106
Cdd:PRK14290  83 ----WDNFTHFSDINDIFNQIFGG 102
DnaJ smart00271
DnaJ molecular chaperone homology domain;
3-61 1.15e-31

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 110.40  E-value: 1.15e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 23503241      3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKK 61
Cdd:smart00271   2 DYYEILGVPRDASLDEIKKAYRKLALKYHPDKNPGDKEEAEEKFKEINEAYEVLSDPEK 60
PRK14297 PRK14297
molecular chaperone DnaJ;
1-106 2.41e-31

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 118.35  E-value: 2.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MAN--YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGG 78
Cdd:PRK14297   1 MASkdYYEVLGLEKGASDDEIKKAFRKLAIKYHPDKNKGNK-EAEEKFKEINEAYQVLSDPQKKAQYDQFGTADFNGAGG 79

                         90       100
                 ....*....|....*....|....*...
gi 23503241   79 ASTPYHSPFDTGyTFRNPEDIFREFFGG 106
Cdd:PRK14297  80 FGSGGFGGFDFS-DMGGFGDIFDSFFGG 106
PRK14280 PRK14280
molecular chaperone DnaJ;
3-106 4.45e-31

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 117.52  E-value: 4.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKnpdNKEE-AEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGAST 81
Cdd:PRK14280   5 DYYEVLGVSKSASKDEIKKAYRKLSKKYHPDI---NKEEgADEKFKEISEAYEVLSDDQKRAQYDQFGHAGPNQGFGGGG 81

                         90       100
                 ....*....|....*....|....*
gi 23503241   82 PYHSPFDTGYTFrnpEDIFREFFGG 106
Cdd:PRK14280  82 FGGGDFGGGFGF---EDIFSSFFGG 103
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 3-105 1.48e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 115.99  E-value: 1.48e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTp 82
Cdd:PRK14301   5 DYYEVLGVSRDASEDEIKKAYRKLALQYHPDRNPDN-PEAEQKFKEAAEAYEVLRDAEKRARYDRFGHAGVNGNGGFGG- 82

                         90       100
                 ....*....|....*....|...
gi 23503241   83 YHSPFDtgyTFRNPEDIFREFFG 105
Cdd:PRK14301  83 FSSAED---IFSHFSDIFGDLFG 102
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 2-105 1.59e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 116.10  E-value: 1.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    2 ANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASt 81
Cdd:PRK14284   1 MDYYTILGVSKTASPEEIKKAYRKLAVKYHPDKNPGDA-EAEKRFKEVSEAYEVLSDAQKRESYDRYGKDGPFAGAGGF- 78

                         90       100
                 ....*....|....*....|....
gi 23503241   82 pyhspfdTGYTFRNPEDIFREFFG 105
Cdd:PRK14284  79 -------GGAGMGNMEDALRTFMG 95
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 3-121 2.01e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 115.66  E-value: 2.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCdswragGGASTP 82
Cdd:PRK14282   5 DYYEILGVSRNATQEEIKRAYKRLVKEWHPDRHPENRKEAEQKFKEIQEAYEVLSDPQKRAMYDRFGY------VGEQPP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 23503241   83 YHSPFDTGYTFrnpEDIFREF--FGGLDPFSFEFWDSPFNS 121
Cdd:PRK14282  79 YQETESGGGFF---EDIFKDFenIFNRDIFDIFFGERRTQE 116
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 3-113 3.15e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 115.29  E-value: 3.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDR---AGCDSWRAGGGA 79
Cdd:PRK14281   4 DYYEVLGVSRSADKDEIKKAYRKLALKYHPDKNPDNK-EAEEHFKEVNEAYEVLSNDDKRRRYDQfghAGVGSSAASGGG 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 23503241   80 STPYHSPFDTGYTFRNPEDIFR--EFFGGLDPFSFE 113
Cdd:PRK14281  83 PGYGGGGGDFNDIFSAFNDMFGggARRGGGSPFGFE 118
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 4-105 3.65e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 114.86  E-value: 3.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTpy 83
Cdd:PRK14294   6 YYEILGVTRDASEEEIKKSYRKLAMKYHPDRNPGDK-EAEELFKEAAEAYEVLSDPKKRGIYDQYGHEGLSGTGFSGF-- 82

                         90       100
                 ....*....|....*....|..
gi 23503241   84 hSPFDTgyTFRNPEDIFREFFG 105
Cdd:PRK14294  83 -SGFDD--IFSSFGDIFEDFFG 101
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 3-106 8.90e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 113.79  E-value: 8.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGcdswragggastp 82
Cdd:PRK14298   6 DYYEILGLSKDASVEDIKKAYRKLAMKYHPDKNKE--PDAEEKFKEISEAYAVLSDAEKRAQYDRFG------------- 70

                         90       100       110
                 ....*....|....*....|....*....|...
gi 23503241   83 yHSPFDTGYT----FRNP-----EDIFREFFGG 106
Cdd:PRK14298  71 -HAGIDNQYSaediFRGAdfggfGDIFEMFFGG 102
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 1-106 1.04e-29

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 113.64  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MAN--YYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdnKEE-AEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGG 77
Cdd:PRK14276   1 MNNteYYDRLGVSKDASQDEIKKAYRKLSKKYHPDIN---KEPgAEEKYKEVQEAYETLSDPQKRAAYDQYGAAGANGGF 77

                         90       100
                 ....*....|....*....|....*....
gi 23503241   78 GASTPYHSPFDTGYTFRNPEDIFREFFGG 106
Cdd:PRK14276  78 GGGAGGFGGFDGSGGFGGFEDIFSSFFGG 106
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 1-106 1.47e-29

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 113.22  E-value: 1.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MA-NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGcDSWRAGGGA 79
Cdd:PRK14278   1 MArDYYGLLGVSRNASDAEIKRAYRKLARELHPDVNPD--EEAQEKFKEISVAYEVLSDPEKRRIVDLGG-DPLESAGGG 77

                         90       100
                 ....*....|....*....|....*..
gi 23503241   80 STPYhspfdtGYTFRNPEDIFREFFGG 106
Cdd:PRK14278  78 GGGF------GGGFGGLGDVFEAFFGG 98
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 3-113 3.40e-29

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 112.56  E-value: 3.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:PRK14291   4 DYYEILGVSRNATQEEIKKAYRRLARKYHPDFNKN--PEAEEKFKEINEAYQVLSDPEKRKLYDQFGHAAFSGSGQQQQG 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 23503241   83 YHSpfDTGYTFRNPEDIFREFFgglDPFSFE 113
Cdd:PRK14291  82 QEG--FSDFGGGNIEDILEDVF---DIFGFG 107
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 3-58 6.90e-29

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 103.01  E-value: 6.90e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23503241   3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNkEEAEKKFKLVSEAYEVLSD 58
Cdd:cd06257   1 DYYDILGVPPDASDEEIKKAYRKLALKYHPDKNPDD-PEAEEKFKEINEAYEVLSD 55
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
1-86 1.05e-28

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 103.64  E-value: 1.05e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241   1 MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRagcdSWRAGGGAS 80
Cdd:COG2214   4 LKDHYAVLGVPPDASLEEIRQAYRRLAKLLHPDRGGELKALAEELFQRLNEAYEVLSDPERRAEYDR----ELGQSGKGS 79


                ....*.
gi 23503241  81 TPYHSP 86
Cdd:COG2214  80 ASQPSA 85
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 1-107 1.82e-28

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 110.36  E-value: 1.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGcdswrAGGGAS 80
Cdd:PRK14292   1 MMDYYELLGVSRTASADEIKSAYRKLALKYHPDRNKE--KGAAEKFAQINEAYAVLSDAEKRAHYDRFG-----TAPGAG 73

                         90       100
                 ....*....|....*....|....*..
gi 23503241   81 TPYHSPFdtGYTFRNPEDIFREFFGGL 107
Cdd:PRK14292  74 MPGGDPF--GGMGFDPMDIFEQLFGGA 98
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 3-106 3.88e-28

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 109.51  E-value: 3.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGG----- 77
Cdd:PRK14277   6 DYYEILGVDRNATEEEIKKAYRRLAKKYHPDLNPGDK-EAEQKFKEINEAYEILSDPQKRAQYDQFGHAAFDPGGfgqgg 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 23503241   78 ---GASTPYHSPFDTGYTFRNPEDIFREFFGG 106
Cdd:PRK14277  85 fgqGGFGGGGFDFDFGGFGDIFEDIFGDFFGT 116
PRK14289 PRK14289
molecular chaperone DnaJ;
3-111 3.32e-27

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 107.22  E-value: 3.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDR---AGCDSWRAGGGA 79
Cdd:PRK14289   6 DYYEVLGVSKTATVDEIKKAYRKKAIQYHPDKNPGDK-EAEEKFKEAAEAYDVLSDPDKRSRYDQfghAGVGGAAGGGGF 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 23503241   80 STPYHSPFDtgyTFRNPEDIFREFFGGLDPFS 111
Cdd:PRK14289  85 SGEGMSMED---IFSMFGDIFGGHGGGFGGFG 113
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 4-106 3.82e-27

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 106.61  E-value: 3.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAG-GGASTP 82
Cdd:PRK14286   6 YYDILGVSKSANDEEIKSAYRKLAIKYHPDKNKGNK-ESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVNAGaGGFGQG 84

                         90       100
                 ....*....|....*....|....
gi 23503241   83 YHSPFDTgyTFRNPEDIFREFFGG 106
Cdd:PRK14286  85 AYTDFSD--IFGDFGDIFGDFFGG 106
PRK14295 PRK14295
molecular chaperone DnaJ;
3-93 7.84e-27

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 106.09  E-value: 7.84e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRA----GCDSWRAGGG 78
Cdd:PRK14295  10 DYYKVLGVPKDATEAEIKKAYRKLAREYHPDANKGDA-KAEERFKEISEAYDVLSDEKKRKEYDEArslfGNGGFRPGPG 88

                         90
                 ....*....|....*
gi 23503241   79 ASTPYHSPFDTGYTF 93
Cdd:PRK14295  89 GGGGGGFNFDLGDLF 103
SEC63 COG5407
Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular ...
 3-62 4.91e-26

Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444165 [Multi-domain]  Cd Length: 61  Bit Score: 95.84  E-value: 4.91e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241   3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKR 62
Cdd:COG5407   1 DPYEVLGVAKTASADEIKKAYRKLAKKYHPDRNKGDP-KAEERFKEINEAYELLSDAEKR 59
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 3-106 7.11e-26

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 103.15  E-value: 7.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGastp 82
Cdd:PRK14285   4 DYYEILGLSKGASKDEIKKAYRKIAIKYHPDKNKGNK-EAESIFKEATEAYEVLIDDNKRAQYDRFGHTAFEGGGG---- 78

                         90       100
                 ....*....|....*....|....*....
gi 23503241   83 yHSPFDTGYT-----FRNPEDIFREFFGG 106
Cdd:PRK14285  79 -FEGFSGGFSgfsdiFEDFGDIFDSFFTG 106
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
3-121 1.01e-25

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 103.75  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGAStp 82
Cdd:NF037946   6 DYYEVLGVDRDADDQEIKKAFRKLAKKYHPDRN--KAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFG-- 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 23503241   83 yhspFDtgytfrnPEDIFREFFGGLDPFSFEFWDSPFNS 121
Cdd:NF037946  82 ----FD-------AFDVFSSFFETINKSGAFLDDSVDES 109
PRK14293 PRK14293
molecular chaperone DnaJ;
1-106 7.04e-25

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 100.45  E-value: 7.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKnpdNKEE-AEKKFKLVSEAYEVLSDSKKRSLYDRAGcdswRAGGGA 79
Cdd:PRK14293   2 AADYYEILGVSRDADKDELKRAYRRLARKYHPDV---NKEPgAEDRFKEINRAYEVLSDPETRARYDQFG----EAGVSG 74

                         90       100
                 ....*....|....*....|....*..
gi 23503241   80 STPYHSPFDTGyTFrnpEDIFREFFGG 106
Cdd:PRK14293  75 AAGFPDMGDMG-GF---ADIFETFFSG 97
PRK14279 PRK14279
molecular chaperone DnaJ;
3-107 1.85e-24

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 99.81  E-value: 1.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYD-------------RAG 69
Cdd:PRK14279  10 DFYKELGVSSDASAEEIKKAYRKLARELHPDANPGDP-AAEERFKAVSEAHDVLSDPAKRKEYDetrrlfagggfggRRF 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 23503241   70 CDSWRAGGGASTPYHSPFDTGYTFRNPEDI----FREFFGGL 107
Cdd:PRK14279  89 DGGGGFGGFGTGGDGAEFNLNDLFDAAGRGggggIGDLFGGL 130
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 3-112 1.99e-24

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 99.51  E-value: 1.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGcdswragggastp 82
Cdd:PRK14283   6 DYYEVLGVDRNADKKEIKKAYRKLARKYHPDVSEE--EGAEEKFKEISEAYAVLSDDEKRQRYDQFG------------- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 23503241   83 yHSPFDtGYT----FRNP--EDIFREFFGGL----DPFSF 112
Cdd:PRK14283  71 -HAGMD-GFSqediFNNInfEDIFQGFGFGIgnifDMFGF 108
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 3-106 6.63e-24

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 96.55  E-value: 6.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:PRK14299   5 DYYAILGVPKNASQDEIKKAFKKLARKYHPDVNKS--PGAEEKFKEINEAYTVLSDPEKRRIYDTYGTTAASAGWQGPPP 82

                         90       100
                 ....*....|....*....|....*.
gi 23503241   83 YHSPFD--TGYTFRNPEDIFREFFGG 106
Cdd:PRK14299  83 GPPGGGdfSGFNVGDFSDFFQQLFGG 108
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 3-106 2.95e-22

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 93.54  E-value: 2.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSW-----RAGG 77
Cdd:PRK14300   4 DYYQILGVSKTASQADLKKAYLKLAKQYHPDTT--DAKDAEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFqnqqsRGGG 81

                         90       100
                 ....*....|....*....|....*....
gi 23503241   78 GASTPYHSPFDTGYTfrnpeDIFREFFGG 106
Cdd:PRK14300  82 GNHGGFHPDINDIFG-----DFFSDFMGG 105
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 4-106 4.12e-21

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 90.65  E-value: 4.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDnkeeaEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGAStpy 83
Cdd:PTZ00037  30 LYEVLNLSKDCTTSEIKKAYRKLAIKHHPDKGGD-----PEKFKEISRAYEVLSDPEKRKIYDEYGEEGLEGGEQPA--- 101

                         90       100
                 ....*....|....*....|...
gi 23503241   84 hspfdtgytfrNPEDIFREFFGG 106
Cdd:PTZ00037 102 -----------DASDLFDLIFGG 113
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 3-106 9.04e-20

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 86.60  E-value: 9.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAG-CDSWRAGGGAST 81
Cdd:PRK14287   5 DYYEVLGVDRNASVDEVKKAYRKLARKYHPDVN--KAPDAEDKFKEVKEAYDTLSDPQKKAHYDQFGhTDPNQGFGGGGA 82

                         90       100
                 ....*....|....*....|....*
gi 23503241   82 PYHSPFDtgytfrnpeDIFREFFGG 106
Cdd:PRK14287  83 GDFGGFS---------DIFDMFFGG 98
PRK14288 PRK14288
molecular chaperone DnaJ;
3-100 1.90e-19

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 85.51  E-value: 1.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:PRK14288   4 SYYEILEVEKHSNQETIKKSYRKLALKYHPDRNAGDK-EAEEKFKLINEAYGVLSDEKKRALYDRYGKKGLNQAGASQSD 82

                         90
                 ....*....|....*....
gi 23503241   83 YHSPF-DTGYTFrnpEDIF 100
Cdd:PRK14288  83 FSDFFeDLGSFF---EDAF 98
PRK10266 PRK10266
curved DNA-binding protein;
3-105 3.62e-18

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 81.41  E-value: 3.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPD--KNPDnkeeAEKKFKLVSEAYEVLSDSKKRSLYDRAgcdsW--RAGGG 78
Cdd:PRK10266   5 DYYAIMGVKPTDDLKTIKTAYRRLARKYHPDvsKEPD----AEARFKEVAEAWEVLSDEQRRAEYDQL----WqhRNDPQ 76

                         90       100
                 ....*....|....*....|....*..
gi 23503241   79 ASTPYHSPFDTGYTFRNPEDIFREFFG 105
Cdd:PRK10266  77 FNRQFQHGDGQSFNAEDFDDIFSSIFG 103
termin_org_DnaJ TIGR03835
terminal organelle assembly protein TopJ; This model describes TopJ (MG_200, CbpA), a DnaJ ...
 3-104 2.13e-17

terminal organelle assembly protein TopJ; This model describes TopJ (MG_200, CbpA), a DnaJ homolog and probable assembly protein of the Mycoplasma terminal organelle. The terminal organelle is involved in both cytadherence and gliding motility. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 274808 [Multi-domain]  Cd Length: 871  Bit Score: 80.63  E-value: 2.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241     3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGcdswragggastp 82
Cdd:TIGR03835   3 DYYEVLGIDRDADEQEIKKAFRKLAKKYHPDRN--KAPDAASIFAEINEANDVLSNPKKRANYDKYG------------- 67

                          90       100
                  ....*....|....*....|..
gi 23503241    83 yHSPFDTGYTFRNPEDIFREFF 104
Cdd:TIGR03835  68 -HDGVDREDDFDFQADVFNSFF 88
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 3-105 1.86e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 77.29  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    3 NYYEVLGVQASASPEDIKKAYRKLALRWHPDKNpdNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTP 82
Cdd:PRK14296   5 DYYEVLGVSKTASEQEIRQAYRKLAKQYHPDLN--KSPDAHDKMVEINEAADVLLDKDKRKQYDQFGHAAFDGSSGFSSN 82

                         90       100
                 ....*....|....*....|....*....
gi 23503241   83 YhSPFDTGYT------FRNPEDIFREFFG 105
Cdd:PRK14296  83 F-GDFEDLFSnmgssgFSSFTNIFSDFFG 110
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
1-64 2.60e-15

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 68.28  E-value: 2.60e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23503241   1 MANYYEVLGVQASASPEDIKKAYRKLALRWHPDK-----NPDNKEEAEKKFKLVSEAYEVLSDSKKRSL 64
Cdd:COG1076   3 LDDAFELLGLPPDADDAELKRAYRKLQREHHPDRlaaglPEEEQRLALQKAAAINEAYETLKDPRGIDL 71
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 4-71 3.56e-10

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 59.41  E-value: 3.56e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23503241     4 YYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNkeEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCD 71
Cdd:PTZ00341  575 FYDILGVGVNADMKEISERYFKLAENYYPPKRSGN--EGFHKFKKINEAYQILGDIDKKKMYNKFGYD 640
djlA PRK09430
co-chaperone DjlA;
5-34 1.49e-07

co-chaperone DjlA;


Pssm-ID: 236512 [Multi-domain]  Cd Length: 267  Bit Score: 50.58  E-value: 1.49e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 23503241    5 YEVLGVQASASPEDIKKAYRKLALRWHPDK 34
Cdd:PRK09430 203 YKVLGVSESDDDQEIKRAYRKLMSEHHPDK 232
ZUO1 COG5269
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / ...
 2-66 3.03e-07

Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227594 [Multi-domain]  Cd Length: 379  Bit Score: 50.42  E-value: 3.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23503241   2 ANYYEVLGV---QASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKK-FKLVSEAYEVLSDSKKRSLYD 66
Cdd:COG5269  43 VDLYALLGLskyRTKAIPPQILKAHKKKVYKYHPDKTAAGGNKGCDEfFKLIQKAREVLGDRKLRLQYD 111
hscB PRK01356
co-chaperone HscB; Provisional
 1-65 5.45e-06

co-chaperone HscB; Provisional


Pssm-ID: 167217 [Multi-domain]  Cd Length: 166  Bit Score: 45.25  E-value: 5.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23503241    1 MANYYEVLGVQA--SASPEDIKKAYRKLALRWHPDKnPDNKEEAEKKFKLVSE---AYEVLSDSKKRSLY 65
Cdd:PRK01356   1 MQNYFQLLGLPQeyNIDLKILEKQYFAMQVKYHPDK-AKTLQEKEQNLIIASElnnAYSTLKDALKRAEY 69
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 7-71 2.49e-03

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 35.73  E-value: 2.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23503241   7 VLGVQASASPEDIKKAYRKLALRWHPDKnpdnkeeaeKKFKLVSEAYEVLSDSKKRSLYDRAGCD 71
Cdd:cd01801  15 TLEVSSSATVADLKKAIHKKKKKLYPER---------QRLRLEVPKGKVLKDDKTLSSYGVKDGS 70
PHA03102 PHA03102
Small T antigen; Reviewed
 8-62 2.66e-03

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 37.34  E-value: 2.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 23503241    8 LGVQASASPEDIKKAYRKLALRWHPDKNPDnkeeaEKKFKLVSEAYEVLSDSKKR 62
Cdd:PHA03102  13 LPRSAWGNLPLMRKAYLRKCLEFHPDKGGD-----EEKMKELNTLYKKFRESVKS 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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