NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1653960582|ref|NP_694984|]
View 

bromodomain and WD repeat-containing protein 3 [Homo sapiens]

Protein Classification

WD40 and Bromo_WDR9_I_like domain-containing protein( domain architecture ID 10077633)

protein containing domains WD40, Bromo_WDR9_I_like, and Bromodomain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 7.03e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 7.03e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319    118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319    198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319    266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1653960582  418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319    330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1301-1442 1.78e-55

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05496:

Pssm-ID: 445827  Cd Length: 119  Bit Score: 188.44  E-value: 1.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1301 NPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLE 1380
Cdd:cd05496      2 DESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYP-------------------------DYRDIIDTPMDLGTVKETLF 56

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1381 AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQK 1442
Cdd:cd05496     57 GGNYDDPMEFAKDVRLIFSNSKSYTPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNE 118
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1130-1242 3.04e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99958  Cd Length: 128  Bit Score: 156.73  E-value: 3.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1130 LYKPQEGEWG--------AHSRDEECERVIQGINHLL---SLDFASPFAVPVDL-SAYPLYCTVVAYPTDLNTIRRRLEN 1197
Cdd:cd05529      1 LYNPLSSEWElfdpgweqPHIRDEERERLISGLDKLLlslQLEIAEYFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLEN 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582 1198 RFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Cdd:cd05529     81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRIL 125
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 7.03e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 7.03e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319    118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319    198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319    266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1653960582  418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319    330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1301-1442 1.78e-55

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 188.44  E-value: 1.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1301 NPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLE 1380
Cdd:cd05496      2 DESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYP-------------------------DYRDIIDTPMDLGTVKETLF 56

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1381 AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQK 1442
Cdd:cd05496     57 GGNYDDPMEFAKDVRLIFSNSKSYTPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNE 118
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-494 2.05e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 195.25  E-value: 2.05e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISD-MAVNYeNTLIAAGSCDKVVRVWC 250
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  251 LRTCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFWQWH----VKTMKFRDRPVKftersrpgvqisCSSF 326
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWDVEtgkcLTTLRGHTDWVN------------SVAF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  327 SSGGMFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMA 406
Cdd:cd00200    144 SPDGTFVASSSQDGTIKLWDLRTGKC--VATLTGHTGEVNSVAFSPDGE--KLLSSSSDGTIKLW------------DLS 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  407 TKMTGNNLPSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIIlSAGH 486
Cdd:cd00200    208 TGKCLGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSA 281


                   ....*...
gi 1653960582  487 DGNIFIWD 494
Cdd:cd00200    282 DGTIRIWD 289
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1130-1242 3.04e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 156.73  E-value: 3.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1130 LYKPQEGEWG--------AHSRDEECERVIQGINHLL---SLDFASPFAVPVDL-SAYPLYCTVVAYPTDLNTIRRRLEN 1197
Cdd:cd05529      1 LYNPLSSEWElfdpgweqPHIRDEERERLISGLDKLLlslQLEIAEYFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLEN 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582 1198 RFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Cdd:cd05529     81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRIL 125
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1147-1233 1.94e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 92.76  E-value: 1.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1147 CERVIQginHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSP 1226
Cdd:pfam00439    1 CLEILD---KLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSV 77


                   ....*..
gi 1653960582 1227 IVKAAKI 1233
Cdd:pfam00439   78 IYKAAEK 84
BROMO smart00297
bromo domain;
1145-1240 7.55e-20

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 86.18  E-value: 7.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  1145 EECERVIQGI-NHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEP 1223
Cdd:smart00297    6 KKLQELLKAVlDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGP 85

                            90
                    ....*....|....*..
gi 1653960582  1224 DSPIVKAAKIVTDVLLR 1240
Cdd:smart00297   86 DSEVYKDAKKLEKFFEK 102
BROMO smart00297
bromo domain;
1306-1430 2.40e-18

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 81.94  E-value: 2.40e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  1306 KKQCKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYG 1385
Cdd:smart00297    9 QELLKAVLDKLDSHPLSWPFLKPVSRKEAP-------------------------DYYDIIKKPMDLKTIKKKLENGKYS 63

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1653960582  1386 SPLEFYKDVRQIFNNSKAYTSnKKSRIYSMMLRLSALFESHIKNI 1430
Cdd:smart00297   64 SVEEFVADFNLMFSNARTYNG-PDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1309-1418 1.73e-13

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 67.34  E-value: 1.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1309 CKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYP-------------------------DYYSVIKKPMDLSTIKKKLENGEYKSLA 55

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1653960582 1389 EFYKDVRQIFNNSKAYtsNKK-SRIYSMMLR 1418
Cdd:pfam00439   56 EFLADVKLIFSNARTY--NGPgSVIYKAAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1164-1438 3.87e-09

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 60.59  E-value: 3.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1164 SPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYR------RISALMWEvryiehNARTFNEPDSPIVKAAKIVTDV 1237
Cdd:COG5076    167 SIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKsfeefvSDLNLMFD------NCKLYNGPDSSVYVDAKELEKY 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1238 LLRFIgdqsctdildtynkikaeernstdaeedteivdldsdgpgtssgrkvkcrgrrqslkcnpdawKKQCKELLSLIY 1317
Cdd:COG5076    241 FLKLI---------------------------------------------------------------EEIPEEMLELSI 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1318 EREDSEPFRQPADLLsyPGHQEQEGESSESVVPERQQdsslSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQI 1397
Cdd:COG5076    258 KPGREEREERESVLI--TNSQAHVGAWPFLRPVSDEE----VPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLF 331

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1653960582 1398 FNN----SKAYTSNKKSRIysmmlrlsALFESHIKNI--ISEYKSAI 1438
Cdd:COG5076    332 FDNcvmyNGEVTDYYKNAN--------VLEDFVIKKTrlIREYPKLI 370
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-494 6.64e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 6.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1653960582   454 TGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-391 7.13e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 7.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  181 SSVYC-VAFDRSGRRIFTGSDDCLVKIWATD----DGRLL----ATLRGHSaEISDMAVN-YENTLIAAGSCDKVVRVWC 250
Cdd:PLN00181   483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  251 LRTCAPVAVLQGHSASITSIQFcpsTKGTNRYLTSTGADGTICFWQWH----VKTMKFRdrpvkftersrpgVQISCSSF 326
Cdd:PLN00181   562 VARSQLVTEMKEHEKRVWSIDY---SSADPTLLASGSDDGSVKLWSINqgvsIGTIKTK-------------ANICCVQF 625

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1653960582  327 -SSGGMFITTGSTDHviRIYYLGSEVPE-KIAELESHTDKVVAVQFCnngDSLRFVSGSRDGTARIW 391
Cdd:PLN00181   626 pSESGRSLAFGSADH--KVYYYDLRNPKlPLCTMIGHSKTVSYVRFV---DSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
212-249 2.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1653960582  212 GRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
178-496 7.03e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 7.03e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319    118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  258 AVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRdrpvkfTERSRPGVQISCSSFSSGGMFITTGS 337
Cdd:COG2319    198 RTLTGHTGAVRSVAFSPD----GKLLASGSADGTVRL--WDLATGKLL------RTLTGHSGSVRSVAFSPDGRLLASGS 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  338 TDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSG 417
Cdd:COG2319    266 ADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLL--ASGSDDGTVRLW------------DLATGKLLRTLTGH 329

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1653960582  418 EDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319    330 TG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
177-529 2.85e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.76  E-value: 2.85e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAP 256
Cdd:COG2319     75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  257 VAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRDRpvkFTERSRPgvqISCSSFSSGGMFITTG 336
Cdd:COG2319    155 LRTLTGHSGAVTSVAFSPD----GKLLASGSDDGTVRL--WDLATGKLLRT---LTGHTGA---VRSVAFSPDGKLLASG 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  337 STDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPS 416
Cdd:COG2319    223 SADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAFSPDGRLL--ASGSADGTVRLW------------DLATGELLRTLTG 286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  417 GEDKITKlkvtmVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLD 496
Cdd:COG2319    287 HSGGVNS-----VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA 360

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1653960582  497 RGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFA 529
Cdd:COG2319    361 TGELLRTL------TGHtGAVTSVAFSPDGRTLA 388
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1301-1442 1.78e-55

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 188.44  E-value: 1.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1301 NPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLE 1380
Cdd:cd05496      2 DESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYP-------------------------DYRDIIDTPMDLGTVKETLF 56

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1381 AGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQK 1442
Cdd:cd05496     57 GGNYDDPMEFAKDVRLIFSNSKSYTPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNE 118
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-494 2.05e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 195.25  E-value: 2.05e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  172 MHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISD-MAVNYeNTLIAAGSCDKVVRVWC 250
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  251 LRTCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFWQWH----VKTMKFRDRPVKftersrpgvqisCSSF 326
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPD----GRILSSSSRDKTIKVWDVEtgkcLTTLRGHTDWVN------------SVAF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  327 SSGGMFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMA 406
Cdd:cd00200    144 SPDGTFVASSSQDGTIKLWDLRTGKC--VATLTGHTGEVNSVAFSPDGE--KLLSSSSDGTIKLW------------DLS 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  407 TKMTGNNLPSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIIlSAGH 486
Cdd:cd00200    208 TGKCLGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSA 281


                   ....*...
gi 1653960582  487 DGNIFIWD 494
Cdd:cd00200    282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
175-539 5.36e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 5.36e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  175 RILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTC 254
Cdd:COG2319     31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  255 APVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFwqWHVKTMKFRDRpvkFTERSRPgvqISCSSFSSGGMFIT 334
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAFSPD----GKTLASGSADGTVRL--WDLATGKLLRT---LTGHSGA---VTSVAFSPDGKLLA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  335 TGSTDHVIRIYYLGSevPEKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWqyqqqewksivlDMATKMTGNNL 414
Cdd:COG2319    179 SGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLW------------DLATGKLLRTL 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  415 PSGEDkitklKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:COG2319    243 TGHSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1653960582  495 LDRGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFACTDSHGHLLL 539
Cdd:COG2319    317 LATGKLLRTL------TGHtGAVRSVAFSPDGKTLASGSDDGTVRL 356
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1130-1242 3.04e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 156.73  E-value: 3.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1130 LYKPQEGEWG--------AHSRDEECERVIQGINHLL---SLDFASPFAVPVDL-SAYPLYCTVVAYPTDLNTIRRRLEN 1197
Cdd:cd05529      1 LYNPLSSEWElfdpgweqPHIRDEERERLISGLDKLLlslQLEIAEYFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLEN 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582 1198 RFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Cdd:cd05529     81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRIL 125
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-392 3.81e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 148.25  E-value: 3.81e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWC 250
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  251 LRTCAPVAVLQGHSASITSIQFCPstkgTNRYLTSTGADGTICFW----QWHVKTMKFRDRPVkftersrpgvqiSCSSF 326
Cdd:cd00200    164 LRTGKCVATLTGHTGEVNSVAFSP----DGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENGV------------NSVAF 227

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1653960582  327 SSGGMFITTGSTDHVIRIYYLGSEVPekIAELESHTDKVVAVQFCNNGdsLRFVSGSRDGTARIWQ 392
Cdd:cd00200    228 SPDGYLLASGSEDGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDG--KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
187-540 6.40e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 6.40e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  187 AFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSAS 266
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  267 ITSIQFCPSTkgtnRYLTSTGADGTICFWQwhVKTMKFRDRPVKFTERsrpgvqISCSSFSSGGMFITTGSTDHVIRIYY 346
Cdd:COG2319     81 VLSVAFSPDG----RLLASASADGTVRLWD--LATGLLLRTLTGHTGA------VRSVAFSPDGKTLASGSADGTVRLWD 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  347 LGSevPEKIAELESHTDKVVAVQFcnNGDSLRFVSGSRDGTARIWqyqqqewksivlDMATKMTGNNLPSGEDkitklKV 426
Cdd:COG2319    149 LAT--GKLLRTLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTG-----AV 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  427 TMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRNYfn 506
Cdd:COG2319    208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL-- 284

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1653960582  507 miegQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
Cdd:COG2319    285 ----TGHsGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-540 8.40e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 8.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  321 ISCSSFSSGGMFITTGSTDHVIRIYYLgsEVPEKIAELESHTDKVVAVQFCNNGDSLrfVSGSRDGTARIWQYQQQEwKS 400
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKTIRLWDLETGE-CV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  401 IVLDMATKMtgnnlpsgedkitklkVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRI 480
Cdd:cd00200     87 RTLTGHTSY----------------VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTF 149

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653960582  481 ILSAGHDGNIFIWDLDRGTKIRNYfnmiegQGH-GAVFDCKFSPDGNHFACTDSHGHLLLF 540
Cdd:cd00200    150 VASSSQDGTIKLWDLRTGKCVATL------TGHtGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
178-349 2.45e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 2.45e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257
Cdd:COG2319    244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  258 AVLQGHSASITSIQFCPstkgTNRYLTSTGADGTICFWQWHVKTmkfrdRPVKFTERSRPgvqISCSSFSSGGMFITTGS 337
Cdd:COG2319    324 RTLTGHTGAVRSVAFSP----DGKTLASGSDDGTVRLWDLATGE-----LLRTLTGHTGA---VTSVAFSPDGRTLASGS 391

                          170
                   ....*....|..
gi 1653960582  338 TDHVIRIYYLGS 349
Cdd:COG2319    392 ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-525 8.99e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 8.99e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  355 IAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIWQYQQQEWKsivldmaTKMTGNNLPsgedkitklkVTMVAWDRY 434
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELL-------RTLKGHTGP----------VRDVAASAD 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  435 DTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRNYfnmiegQGH- 513
Cdd:cd00200     63 GTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL------RGHt 135

                          170
                   ....*....|..
gi 1653960582  514 GAVFDCKFSPDG 525
Cdd:cd00200    136 DWVNSVAFSPDG 147
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1147-1233 1.94e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 92.76  E-value: 1.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1147 CERVIQginHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSP 1226
Cdd:pfam00439    1 CLEILD---KLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSV 77


                   ....*..
gi 1653960582 1227 IVKAAKI 1233
Cdd:pfam00439   78 IYKAAEK 84
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1145-1232 1.76e-20

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 87.81  E-value: 1.76e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1145 EECERVIQGINHLLsLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPD 1224
Cdd:cd04369      3 KKLRSLLDALKKLK-RDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPG 81


                   ....*...
gi 1653960582 1225 SPIVKAAK 1232
Cdd:cd04369     82 SPIYKDAK 89
BROMO smart00297
bromo domain;
1145-1240 7.55e-20

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 86.18  E-value: 7.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  1145 EECERVIQGI-NHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEP 1223
Cdd:smart00297    6 KKLQELLKAVlDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGP 85

                            90
                    ....*....|....*..
gi 1653960582  1224 DSPIVKAAKIVTDVLLR 1240
Cdd:smart00297   86 DSEVYKDAKKLEKFFEK 102
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1305-1427 3.77e-19

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 83.96  E-value: 3.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1305 WKKQCKELLSLIYE--REDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAG 1382
Cdd:cd04369      1 LKKKLRSLLDALKKlkRDLSEPFLEPVDPKEAP-------------------------DYYEVIKNPMDLSTIKKKLKNG 55

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1653960582 1383 NYGSPLEFYKDVRQIFNNSKAYtsNKK-SRIYSMMLRLSALFESHI 1427
Cdd:cd04369     56 EYKSLEEFEADVRLIFSNAKTY--NGPgSPIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
1306-1430 2.40e-18

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 81.94  E-value: 2.40e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  1306 KKQCKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYG 1385
Cdd:smart00297    9 QELLKAVLDKLDSHPLSWPFLKPVSRKEAP-------------------------DYYDIIKKPMDLKTIKKKLENGKYS 63

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1653960582  1386 SPLEFYKDVRQIFNNSKAYTSnKKSRIYSMMLRLSALFESHIKNI 1430
Cdd:smart00297   64 SVEEFVADFNLMFSNARTYNG-PDSEVYKDAKKLEKFFEKKLREL 107
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 1312-1427 5.73e-16

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 75.17  E-value: 5.73e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1312 LLSLIYEREDSEPFRQPAD--LLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPLE 1389
Cdd:cd05495     12 LEKLYKQDPESLPFRQPVDpkLLGIP-------------------------DYFDIVKNPMDLSTIRRKLDTGQYQDPWQ 66

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1653960582 1390 FYKDVRQIFNNSKAYtsNKK-SRIYSMMLRLSALFESHI 1427
Cdd:cd05495     67 YVDDVWLMFDNAWLY--NRKtSRVYKYCTKLAEVFEQEI 103
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 1305-1425 8.28e-16

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 74.67  E-value: 8.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1305 WKKQCKELLSLIYEREDSEPFRQPADLLSYPGHqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNY 1384
Cdd:cd05506      1 VMKQCGTLLRKLMKHKWGWVFNAPVDVVALGLP-----------------------DYFDIIKKPMDLGTVKKKLEKGEY 57

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1653960582 1385 GSPLEFYKDVRQIFNNSKAYTSnKKSRIYSMMLRLSALFES 1425
Cdd:cd05506     58 SSPEEFAADVRLTFANAMRYNP-PGNDVHTMAKELLKIFET 97
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1163-1242 2.49e-15

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 73.36  E-value: 2.49e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1163 ASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Cdd:cd05509     19 AWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKL 98
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1309-1418 1.73e-13

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 67.34  E-value: 1.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1309 CKELLSLIYEREDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYP-------------------------DYYSVIKKPMDLSTIKKKLENGEYKSLA 55

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1653960582 1389 EFYKDVRQIFNNSKAYtsNKK-SRIYSMMLR 1418
Cdd:pfam00439   56 EFLADVKLIFSNARTY--NGPgSVIYKAAEK 84
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1308-1430 1.09e-12

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 65.65  E-value: 1.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1308 QCKELLSLIYEREDSEPFRQPADllsypghqeqegessESVVPerqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSP 1387
Cdd:cd05509      5 QLKKVLDSLKNHKSAWPFLEPVD---------------KEEAP----------DYYDVIKKPMDLSTMEEKLENGYYVTL 59

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1653960582 1388 LEFYKDVRQIFNNSKAYtsNKKSRIYSMML-RLSALFESHIKNI 1430
Cdd:cd05509     60 EEFVADLKLIFDNCRLY--NGPDTEYYKCAnKLEKFFWKKLKEL 101
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1360-1424 7.01e-12

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 63.45  E-value: 7.01e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1653960582 1360 EDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTsNKKSRIYSMMLRLSALFE 1424
Cdd:cd05498     36 HDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN-PPDHPVHAMARKLQDVFE 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1306-1427 1.22e-11

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 62.72  E-value: 1.22e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1306 KKQCKELLSLIY---EREDSEPFRQPADllsypghqeqegessesvvPERQQdsslSEDYQDVIDTPVDFSTVKETLEAG 1382
Cdd:cd05500      3 KHQHKFLLSSIRslkRLKDARPFLVPVD-------------------PVKLN----IPHYPTIIKKPMDLGTIERKLKSN 59

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582 1383 NYGSPLEFYKDVRQIFNNSKAYtSNKKSRIYSMMLRLSALFESHI 1427
Cdd:cd05500     60 VYTSVEEFTADFNLMVDNCLTF-NGPEHPVSQMGKRLQAAFEKHL 103
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1309-1400 2.56e-11

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 61.62  E-value: 2.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1309 CKELLSLIYEREDSEPFRQPADLLSYPGhqeqegessesvvperqqdsslsedYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
Cdd:cd05503      5 CETILDEMEAHEDAWPFLEPVNTKLVPG-------------------------YRKIIKKPMDFSTIREKLESGQYKTLE 59

                           90
                   ....*....|..
gi 1653960582 1389 EFYKDVRQIFNN 1400
Cdd:cd05503     60 EFAEDVRLVFDN 71
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 1306-1418 3.13e-11

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 61.40  E-value: 3.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1306 KKQCKELLSLIYEREDSEPFRQPadllsypghqeqegessesvvPERQQdsslSEDYQDVIDTPVDFSTVKETLEAGNYG 1385
Cdd:cd05505      2 LQKCEEILSKILKYRFSWPFREP---------------------VTADE----AEDYKKVITNPMDLQTMQTKCSCGSYS 56

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1653960582 1386 SPLEFYKDVRQIFNNSKAYTSNkKSRIYSMMLR 1418
Cdd:cd05505     57 SVQEFLDDMKLVFSNAEKYYEN-GSYVLSCMRK 88
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1162-1237 5.01e-11

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 61.14  E-value: 5.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1653960582 1162 FASPFAVPVDLSAYPL--YCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDV 1237
Cdd:cd05498     20 YAWPFYKPVDPEALGLhdYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDV 97
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 1306-1433 8.34e-11

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 60.77  E-value: 8.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1306 KKQCKELLSLIYEREDSEPFRQPAdllsypghqeqegessesvvperqqdSSLSEDYQDVIDTPVDFSTVKETLEAGN-- 1383
Cdd:cd05502      6 QRKCERLLLELYCHELSLPFHEPV--------------------------SPSVPNYYKIIKTPMDLSLIRKKLQPKSpq 59

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1384 -YGSPLEFYKDVRQIFNNskAYTSNK-KSRIYSMMLRLSALFESHIKNIISE 1433
Cdd:cd05502     60 hYSSPEEFVADVRLMFKN--CYKFNEeDSEVAQAGKELELFFEEQLKEILPD 109
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1163-1233 1.29e-10

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 59.70  E-value: 1.29e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653960582 1163 ASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKI 1233
Cdd:cd05503     18 AWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGHN 88
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1162-1239 1.85e-10

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 59.74  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1162 FASPFAVPVDLSAY--PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLL 1239
Cdd:cd05497     22 FAWPFQQPVDAVKLnlPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLFL 101
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1173-1240 2.12e-10

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 59.24  E-value: 2.12e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1653960582 1173 SAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLR 1240
Cdd:cd05515     34 SEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVLLE 101
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1147-1232 2.15e-10

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 59.22  E-value: 2.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1147 CERVIQGINHLLSLDFASPFAVPVDLSAY--PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPD 1224
Cdd:cd05499      5 CEEVLKELMKPKHSAYNWPFLDPVDPVALniPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEG 84


                   ....*...
gi 1653960582 1225 SPIVKAAK 1232
Cdd:cd05499     85 TDVYMMGH 92
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1163-1240 2.73e-10

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 58.86  E-value: 2.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1163 ASPFAVPVDLSAY--PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLR 1240
Cdd:cd05500     22 ARPFLVPVDPVKLniPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQAAFEK 101
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 1309-1430 5.69e-10

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 58.56  E-value: 5.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1309 CKELLSLIYEREDSEPFRQPAdllsypghqeqegesSESVVPerqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
Cdd:cd05504     17 LEQLLVEIVKHKDSWPFLRPV---------------SKIEVP----------DYYDIIKKPMDLGTIKEKLNMGEYKLAE 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1653960582 1389 EFYKDVRQIFNNSKAYtSNKKSRIYSMMLRLSALFESHIKNI 1430
Cdd:cd05504     72 EFLSDIQLVFSNCFLY-NPEHTSVYKAGTRLQRFFIKRCRKL 112
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1164-1438 3.87e-09

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 60.59  E-value: 3.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1164 SPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYR------RISALMWEvryiehNARTFNEPDSPIVKAAKIVTDV 1237
Cdd:COG5076    167 SIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKsfeefvSDLNLMFD------NCKLYNGPDSSVYVDAKELEKY 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1238 LLRFIgdqsctdildtynkikaeernstdaeedteivdldsdgpgtssgrkvkcrgrrqslkcnpdawKKQCKELLSLIY 1317
Cdd:COG5076    241 FLKLI---------------------------------------------------------------EEIPEEMLELSI 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1318 EREDSEPFRQPADLLsyPGHQEQEGESSESVVPERQQdsslSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQI 1397
Cdd:COG5076    258 KPGREEREERESVLI--TNSQAHVGAWPFLRPVSDEE----VPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLF 331

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1653960582 1398 FNN----SKAYTSNKKSRIysmmlrlsALFESHIKNI--ISEYKSAI 1438
Cdd:COG5076    332 FDNcvmyNGEVTDYYKNAN--------VLEDFVIKKTrlIREYPKLI 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 457-531 7.33e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 7.33e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1653960582  457 LLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWDLDRGTKIRnyfnmiEGQGH-GAVFDCKFSPDGNHFACT 531
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR------TLKGHtGPVRDVAASADGTYLASG 69
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 1175-1232 8.99e-09

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 54.75  E-value: 8.99e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1653960582 1175 YPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAK 1232
Cdd:cd05517     36 YPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDAN 93
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 1157-1238 1.18e-08

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 54.29  E-value: 1.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1157 LLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAK-IVT 1235
Cdd:cd05507     15 LASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVeMQR 94


                   ...
gi 1653960582 1236 DVL 1238
Cdd:cd05507     95 EVM 97
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1163-1234 1.03e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 51.62  E-value: 1.03e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1163 ASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIV 1234
Cdd:cd05508     20 AEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAAKAI 91
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1362-1426 1.34e-07

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 51.13  E-value: 1.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1653960582 1362 YQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNskAYTSNKK-SRIYSMMLRLSALFESH 1426
Cdd:cd05499     38 YFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKN--CYTFNPEgTDVYMMGHQLEEVFNDK 101
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1152-1232 2.18e-07

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 51.11  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1152 QGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAA 1231
Cdd:cd05511      7 EIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKA 86


                   .
gi 1653960582 1232 K 1232
Cdd:cd05511     87 K 87
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 1165-1223 4.56e-07

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 49.64  E-value: 4.56e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653960582 1165 PFAVPVDLSAY--PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEP 1223
Cdd:cd05506     20 VFNAPVDVVALglPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPP 80
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 1175-1239 6.15e-07

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 49.26  E-value: 6.15e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1653960582 1175 YPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLL 1239
Cdd:cd05519     36 YPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFK 100
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-494 6.64e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 6.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1653960582   454 TGQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-391 7.13e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 7.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  181 SSVYC-VAFDRSGRRIFTGSDDCLVKIWATD----DGRLL----ATLRGHSaEISDMAVN-YENTLIAAGSCDKVVRVWC 250
Cdd:PLN00181   483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  251 LRTCAPVAVLQGHSASITSIQFcpsTKGTNRYLTSTGADGTICFWQWH----VKTMKFRdrpvkftersrpgVQISCSSF 326
Cdd:PLN00181   562 VARSQLVTEMKEHEKRVWSIDY---SSADPTLLASGSDDGSVKLWSINqgvsIGTIKTK-------------ANICCVQF 625

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1653960582  327 -SSGGMFITTGSTDHviRIYYLGSEVPE-KIAELESHTDKVVAVQFCnngDSLRFVSGSRDGTARIW 391
Cdd:PLN00181   626 pSESGRSLAFGSADH--KVYYYDLRNPKlPLCTMIGHSKTVSYVRFV---DSSTLVSSSTDNTLKLW 687
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1310-1413 1.23e-06

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 48.55  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1310 KELLSLIYEREDSEPFRQPADLlsypghqeqegesseSVVPerqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPLE 1389
Cdd:cd05512      7 RKTLDQLQEKDTAEIFSEPVDL---------------SEVP----------DYLDHIKQPMDFSTMRKKLESQRYRTLED 61

                           90       100
                   ....*....|....*....|....
gi 1653960582 1390 FYKDVRQIFNNSKAYtsNKKSRIY 1413
Cdd:cd05512     62 FEADFNLIINNCLAY--NAKDTIF 83
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1161-1231 1.63e-06

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 48.16  E-value: 1.63e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653960582 1161 DFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAA 1231
Cdd:cd05512     17 DTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAA 87
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-207 1.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.64e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1653960582   171 KMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIW 207
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 1147-1232 1.79e-06

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 48.44  E-value: 1.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1147 CERVIQginHLLSLDFASPFAVPVDLSAyPLYCTVVAYPTDLNTIRRRLENRF---YRRISALMWEVRYIEHNARTFNEP 1223
Cdd:cd05502      9 CERLLL---ELYCHELSLPFHEPVSPSV-PNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCYKFNEE 84


                   ....*....
gi 1653960582 1224 DSPIVKAAK 1232
Cdd:cd05502     85 DSEVAQAGK 93
WD40 pfam00400
WD domain, G-beta repeat;
212-249 2.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1653960582  212 GRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-249 2.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 2.09e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1653960582   211 DGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVW 249
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
174-207 2.46e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1653960582  174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIW 207
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 1303-1407 2.67e-06

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 47.74  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1303 DAWKKQCKELLSLIYEREDSEPFRQPadllsypghqeqegessesvVPERQqdsslSEDYQDVIDTPVDFSTVKETLEAG 1382
Cdd:cd05507      2 RAWKKAILLVYRTLASHRYASVFLKP--------------------VTEDI-----APGYHSVVYRPMDLSTIKKNIENG 56

                           90       100
                   ....*....|....*....|....*
gi 1653960582 1383 NYGSPLEFYKDVRQIFNNSKAYTSN 1407
Cdd:cd05507     57 TIRSTAEFQRDVLLMFQNAIMYNSS 81
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 1353-1432 2.73e-06

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 47.42  E-value: 2.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1353 QQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYtsNKKSRIYSMMLRLSALFESHIKNIIS 1432
Cdd:cd05501     24 ISKPYYIRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLF--YKDDDFGQVGITLEKKFEKNFKEVFA 101
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1361-1428 2.84e-06

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 47.80  E-value: 2.84e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNskAYTSNKKSR-IYSMMLRLSALFESHIK 1428
Cdd:cd05497     39 DYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTN--CYIYNKPGDdVVLMAQTLEKLFLQKLA 105
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-295 4.04e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 4.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1653960582   253 TCAPVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFW 295
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1175-1242 6.40e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 46.55  E-value: 6.40e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1653960582 1175 YPLYCTVVAYPTDLNTIRRRLENrfYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFI 1242
Cdd:cd05521     37 YPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYINDVI 102
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 1306-1430 6.72e-06

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 46.65  E-value: 6.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1306 KKQCKELLSLI--YERED----SEPFRQpadllsypghqeqegessesvVPERQQdssLSEDYQdVIDTPVDFSTVKETL 1379
Cdd:cd05516      3 TKKMNKIVDVVikYKDSDgrqlAEVFIQ---------------------LPSRKE---LPEYYE-LIRKPVDFKKIKERI 57

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1653960582 1380 EAGNYGSPLEFYKDVRQIFNNSKAYtSNKKSRIYSMMLRLSALFESHIKNI 1430
Cdd:cd05516     58 RNHKYRSLEDLEKDVMLLCQNAQTF-NLEGSLIYEDSIVLQSVFKSARQKI 107
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 353-391 6.72e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 6.72e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1653960582   353 EKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIW 391
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 1349-1434 7.15e-06

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 46.56  E-value: 7.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1349 VPERQQDSslseDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSnKKSRIYSMMLRLSALFESHIK 1428
Cdd:cd05524     32 VPKRRNEP----EYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYK-PDSPEHKDACKLWELFLSARN 106


                   ....*.
gi 1653960582 1429 NIISEY 1434
Cdd:cd05524    107 EVLSGG 112
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1166-1232 1.09e-05

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 45.86  E-value: 1.09e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1653960582 1166 FAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAK 1232
Cdd:cd05513     22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAK 88
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 1360-1404 1.18e-05

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 46.20  E-value: 1.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582 1360 EDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAY 1404
Cdd:cd05528     34 PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEY 78
WD40 pfam00400
WD domain, G-beta repeat;
455-494 1.82e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 1.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1653960582  455 GQLLHTLSGHDDEVFVLEAHPfDQRIILSAGHDGNIFIWD 494
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1361-1416 3.27e-05

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 44.95  E-value: 3.27e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYtsNKKSRIYSMM 1416
Cdd:cd05511     32 DYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLY--NGPDSVYTKK 85
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1361-1431 3.28e-05

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 44.62  E-value: 3.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEagNYGSPLEFYKDVRQIFNNSKAYTSnKKSRIYsmmlRLSALFESHIKNII 1431
Cdd:cd05521     39 DYYKIIKNPLSLNTVKKRLP--HYTNAQEFVNDLAQIPWNARLYNT-KGSVIY----KYALILEKYINDVI 102
WD40 pfam00400
WD domain, G-beta repeat;
256-295 4.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 4.90e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1653960582  256 PVAVLQGHSASITSIQFCPStkgtNRYLTSTGADGTICFW 295
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1145-1244 5.22e-05

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 44.35  E-value: 5.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1145 EECERVIqgiNHLLSL-DFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFN-E 1222
Cdd:cd05510     10 ESLDKVL---NELKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNsD 86

                           90       100
                   ....*....|....*....|....*
gi 1653960582 1223 PDSPIVKAA---KIVTDVLLRFIGD 1244
Cdd:cd05510     87 PSHPLRRHAnfmKKKAEHLLKLIPD 111
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 197-390 6.11e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 6.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  197 TGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCA-PVAVLQGHSASITSIQFCPS 275
Cdd:PLN00181   593 SGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS 672

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582  276 TKgtnryLTSTGADGTICFWQWHVKTMKFRDRPV-KFTERSRPGVQISCsSFSSGgmFITTGSTDHVIRIYYLGSEVP-- 352
Cdd:PLN00181   673 ST-----LVSSSTDNTLKLWDLSMSISGINETPLhSFMGHTNVKNFVGL-SVSDG--YIATGSETNEVFVYHKAFPMPvl 744

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1653960582  353 -------EKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARI 390
Cdd:PLN00181   745 sykfktiDPVSGLEVDDASQFISSVCWRGQSSTLVAANSTGNIKI 789
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 1163-1242 8.60e-05

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 43.59  E-value: 8.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1163 ASPFAVPVD--LSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLR 1240
Cdd:cd05495     22 SLPFRQPVDpkLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKLAEVFEQ 101


                   ..
gi 1653960582 1241 FI 1242
Cdd:cd05495    102 EI 103
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1361-1430 1.02e-04

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 43.58  E-value: 1.02e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNI 1430
Cdd:cd05510     40 DYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSDPSHPLRRHANFMKKKAEHLLKLI 109
WD40 pfam00400
WD domain, G-beta repeat;
353-391 1.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.63e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1653960582  353 EKIAELESHTDKVVAVQFCNNGDslRFVSGSRDGTARIW 391
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1155-1231 2.48e-04

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 42.23  E-value: 2.48e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1653960582 1155 NHLLSLDFASpfaVPvDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAA 1231
Cdd:cd05522     21 GRLLTLHFEK---LP-DKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDA 93
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 1165-1242 2.61e-04

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 42.38  E-value: 2.61e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1653960582 1165 PFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIvkaAKIVTDVLLRFI 1242
Cdd:cd05504     32 PFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSV---YKAGTRLQRFFI 106
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 1145-1228 2.99e-04

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 41.75  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1145 EECERVIQGInhlLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPD 1224
Cdd:cd05505      3 QKCEEILSKI---LKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENG 79


                   ....
gi 1653960582 1225 SPIV 1228
Cdd:cd05505     80 SYVL 83
WD40 COG2319
WD40 repeat [General function prediction only];
174-211 3.03e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 3.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1653960582  174 KRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDD 211
Cdd:COG2319    366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 1175-1238 6.69e-04

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 40.89  E-value: 6.69e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1653960582 1175 YPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVL 1238
Cdd:cd05518     36 YPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVL 99
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1361-1404 1.17e-03

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 40.07  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAY 1404
Cdd:cd05525     40 DYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKY 83
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 1176-1237 3.34e-03

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 38.95  E-value: 3.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1176 PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDV 1237
Cdd:cd05516     38 PEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSV 99
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1362-1413 4.29e-03

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 38.55  E-value: 4.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1653960582 1362 YQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYtsNKKSRIY 1413
Cdd:cd05513     34 YSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKY--NKPDTIY 83
Bromo_TBP7_like cd05491
Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is ...
 1183-1239 4.50e-03

Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99923  Cd Length: 119  Bit Score: 38.97  E-value: 4.50e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1653960582 1183 AYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSpIVKAAKIVTDVLL 1239
Cdd:cd05491     62 FYNMDLDTIEERLWNGYYATPKDFLKDIKRIVRDAKTIGDRER-LLKANEMFANAEL 117
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1312-1407 4.56e-03

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 38.13  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653960582 1312 LLSLIYER---EDSEPFRQPADLLSYPghqeqegessesvvperqqdsslseDYQDVIDTPVDFSTVKETLEAGNYGSPL 1388
Cdd:cd05508      7 LLKFALERmkqPGAEPFLKPVDLEQFP-------------------------DYAQYVFKPMDLSTLEKNVRKKAYGSTD 61

                           90
                   ....*....|....*....
gi 1653960582 1389 EFYKDVRQIFNNSKAYTSN 1407
Cdd:cd05508     62 AFLADAKWILHNAIIYNGG 80
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 1173-1231 5.88e-03

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 38.09  E-value: 5.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1653960582 1173 SAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAA 1231
Cdd:cd05520     34 RKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDA 92
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 1176-1231 5.96e-03

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 38.47  E-value: 5.96e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1653960582 1176 PLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAA 1231
Cdd:cd05524     39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDA 94
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1361-1413 7.14e-03

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 38.05  E-value: 7.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1653960582 1361 DYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYtSNKKSRIY 1413
Cdd:cd05515     38 DYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKY-NEPDSQIY 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH