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Conserved domains on  [gi|116325985|ref|NP_690878|]
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protein NATD1 [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10629420)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to vertebrate protein NATD1

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  9175471|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 29-103 2.22e-23

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


:

Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 85.65  E-value: 2.22e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116325985   29 QFTVRLNGCHDRAVLLYEyVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENP 103
Cdd:pfam14542   1 RFEIRVDGGAEVAFLTYR-RGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPLCSYVAAYLEKHP 74
 
Name Accession Description Interval E-value
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 29-103 2.22e-23

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 85.65  E-value: 2.22e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116325985   29 QFTVRLNGCHDRAVLLYEyVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENP 103
Cdd:pfam14542   1 RFEIRVDGGAEVAFLTYR-RGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPLCSYVAAYLEKHP 74
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
19-103 9.27e-21

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 79.04  E-value: 9.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325985  19 IRVEHDRRRRQFTVRLNGcHDRAVLLYEYVGKRIVdLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKY 98
Cdd:COG2388    1 MEITHNEEKGRFELEVDG-ELAGELTYRLEGGVII-ITHTEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAY 78


                 ....*
gi 116325985  99 VKENP 103
Cdd:COG2388   79 FERHP 83
 
Name Accession Description Interval E-value
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 29-103 2.22e-23

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 85.65  E-value: 2.22e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116325985   29 QFTVRLNGCHDRAVLLYEyVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENP 103
Cdd:pfam14542   1 RFEIRVDGGAEVAFLTYR-RGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKIVPLCSYVAAYLEKHP 74
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
19-103 9.27e-21

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 79.04  E-value: 9.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116325985  19 IRVEHDRRRRQFTVRLNGcHDRAVLLYEYVGKRIVdLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKY 98
Cdd:COG2388    1 MEITHNEEKGRFELEVDG-ELAGELTYRLEGGVII-ITHTEVPPALRGQGIASALVEAALDDARERGLKVVPLCPFVAAY 78


                 ....*
gi 116325985  99 VKENP 103
Cdd:COG2388   79 FERHP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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