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Conserved domains on  [gi|22749499|ref|NP_689979|]
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transmembrane protein 256 precursor [Homo sapiens]

Protein Classification

DUF423 domain-containing protein( domain architecture ID 10515198)

DUF423 domain-containing protein, possibly an integral membrane protein similar to human transmembrane protein 256 and Bacillus subtilis membrane protein YwdK

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-98 1.34e-14

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


:

Pssm-ID: 461234  Cd Length: 86  Bit Score: 63.31  E-value: 1.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749499    22 FASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPHC-------RKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....
gi 22749499    95 TLAP 98
Cdd:pfam04241  80 PITP 83
 
Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-98 1.34e-14

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 63.31  E-value: 1.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749499    22 FASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPHC-------RKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....
gi 22749499    95 TLAP 98
Cdd:pfam04241  80 PITP 83
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
11-105 4.07e-06

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 42.47  E-value: 4.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749499  11 LGALSGAAALGFASYGAHG-AQFPDAYGKELFDKANKHHFLHSLALLGV------PHCRKPLWAGLLLASGTTLFCTSFY 83
Cdd:COG2363   9 LGALLGALAVALGAFGAHGlKGRLSPEALATFETAVRYQMYHALALLALgllaqrLPSRLLRLAGWLFLLGILLFSGSLY 88

                        90       100
                ....*....|....*....|..
gi 22749499  84 YQALSGDPSIQTLAPAGGTLLL 105
Cdd:COG2363  89 ALALTGIKLLGAITPIGGLLFI 110
 
Name Accession Description Interval E-value
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 22-98 1.34e-14

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 63.31  E-value: 1.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749499    22 FASYGAHGAQfPDAYGKELFDKANKHHFLHSLALLGVPHC-------RKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQ 94
Cdd:pfam04241   1 LGAFGAHGLK-ARPEQLAVFETAVQYQMYHALALLAVALLargapraRLLNLAGWLFLAGIVLFSGSLYALALTGIKWLG 79


                  ....
gi 22749499    95 TLAP 98
Cdd:pfam04241  80 PITP 83
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
11-105 4.07e-06

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 42.47  E-value: 4.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749499  11 LGALSGAAALGFASYGAHG-AQFPDAYGKELFDKANKHHFLHSLALLGV------PHCRKPLWAGLLLASGTTLFCTSFY 83
Cdd:COG2363   9 LGALLGALAVALGAFGAHGlKGRLSPEALATFETAVRYQMYHALALLALgllaqrLPSRLLRLAGWLFLLGILLFSGSLY 88

                        90       100
                ....*....|....*....|..
gi 22749499  84 YQALSGDPSIQTLAPAGGTLLL 105
Cdd:COG2363  89 ALALTGIKLLGAITPIGGLLFI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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