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Conserved domains on  [gi|22749235|ref|NP_689814|]
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zinc finger protein 709 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.93e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22749235     3 SVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-551 4.57e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235  77 SQFGETISQTPNPKPNKKTFTRV---KPYECSVCGKDYMCHSSLNRHMRSHTehrsyeyhkyGEKSYEC--KECGKRFSF 151
Cdd:COG5048   6 SQSSSSNNSVLSSTPKSTLKSLSnapRPDSCPNCTDSFSRLEHLTRHIRSHT----------GEKPSQCsySGCDKSFSR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 152 RSSFRIHERTHTGEKPYKC-KQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKEC- 229
Cdd:COG5048  76 PLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNn 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 230 GKTFSHPSSFRNHERTHSGEKPyeckqcgKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHERIHTGEKPYK 309
Cdd:COG5048 156 SSSVNTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 310 CKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHmimhtgngpykckecgkafdcpSSFQIHERTHTG- 388
Cdd:COG5048 229 LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS----------------------SPNESDSSSEKGf 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 389 EKPYECKQCGKAFSCSSSFRMHERT--HTGE--KPHEC--KQCGKAFSCSSSVRIHERTHTGEKPYECKQC-------GK 455
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPL 366

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 456 AFSCSSSFRMHERIHTGEKPYEC--KQCGKAFSFSSSFRMHERTHTGEKPYECK--QCGKAFSCSSSFRMHERTHTGEKP 531
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                       490       500
                ....*....|....*....|
gi 22749235 532 YECKQCGKAFSCSSSIRIHE 551
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 6.06e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   574 SVRMHERTHTGVKPYECKQCDKAFSC 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-627 7.23e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   602 SFRIHERTHTGEKPYACQQCGKAFKC 627
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-571 7.90e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.90e-03
                          10        20
                  ....*....|....*....|....
gi 22749235   548 RIHERTHTGEKPYECKQCGKAFSC 571
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.93e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22749235     3 SVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 8.35e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 8.35e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 22749235      4 VVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 5.73e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 5.73e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 22749235   6 FEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASI 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-551 4.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235  77 SQFGETISQTPNPKPNKKTFTRV---KPYECSVCGKDYMCHSSLNRHMRSHTehrsyeyhkyGEKSYEC--KECGKRFSF 151
Cdd:COG5048   6 SQSSSSNNSVLSSTPKSTLKSLSnapRPDSCPNCTDSFSRLEHLTRHIRSHT----------GEKPSQCsySGCDKSFSR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 152 RSSFRIHERTHTGEKPYKC-KQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKEC- 229
Cdd:COG5048  76 PLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNn 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 230 GKTFSHPSSFRNHERTHSGEKPyeckqcgKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHERIHTGEKPYK 309
Cdd:COG5048 156 SSSVNTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 310 CKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHmimhtgngpykckecgkafdcpSSFQIHERTHTG- 388
Cdd:COG5048 229 LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS----------------------SPNESDSSSEKGf 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 389 EKPYECKQCGKAFSCSSSFRMHERT--HTGE--KPHEC--KQCGKAFSCSSSVRIHERTHTGEKPYECKQC-------GK 455
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPL 366

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 456 AFSCSSSFRMHERIHTGEKPYEC--KQCGKAFSFSSSFRMHERTHTGEKPYECK--QCGKAFSCSSSFRMHERTHTGEKP 531
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                       490       500
                ....*....|....*....|
gi 22749235 532 YECKQCGKAFSCSSSIRIHE 551
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-235 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|..
gi 22749235   214 HMRMHTGEKPYKCKECGKTFSH 235
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 6.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   574 SVRMHERTHTGVKPYECKQCDKAFSC 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-627 7.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   602 SFRIHERTHTGEKPYACQQCGKAFKC 627
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-571 7.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.90e-03
                          10        20
                  ....*....|....*....|....
gi 22749235   548 RIHERTHTGEKPYECKQCGKAFSC 571
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.93e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22749235     3 SVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 8.35e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 8.35e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 22749235      4 VVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 5.73e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 5.73e-17
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 22749235   6 FEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASI 43
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-551 4.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235  77 SQFGETISQTPNPKPNKKTFTRV---KPYECSVCGKDYMCHSSLNRHMRSHTehrsyeyhkyGEKSYEC--KECGKRFSF 151
Cdd:COG5048   6 SQSSSSNNSVLSSTPKSTLKSLSnapRPDSCPNCTDSFSRLEHLTRHIRSHT----------GEKPSQCsySGCDKSFSR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 152 RSSFRIHERTHTGEKPYKC-KQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKEC- 229
Cdd:COG5048  76 PLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNn 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 230 GKTFSHPSSFRNHERTHSGEKPyeckqcgKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHERIHTGEKPYK 309
Cdd:COG5048 156 SSSVNTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 310 CKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHmimhtgngpykckecgkafdcpSSFQIHERTHTG- 388
Cdd:COG5048 229 LTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS----------------------SPNESDSSSEKGf 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 389 EKPYECKQCGKAFSCSSSFRMHERT--HTGE--KPHEC--KQCGKAFSCSSSVRIHERTHTGEKPYECKQC-------GK 455
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPL 366

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 456 AFSCSSSFRMHERIHTGEKPYEC--KQCGKAFSFSSSFRMHERTHTGEKPYECK--QCGKAFSCSSSFRMHERTHTGEKP 531
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                       490       500
                ....*....|....*....|
gi 22749235 532 YECKQCGKAFSCSSSIRIHE 551
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-579 4.97e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 4.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 166 KPYKCKQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTT--FRGHMRMHTGEKPYKCKECGKTFSHPSSFRNHE 243
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 244 RTHSGE-KPYECKQCGKAFRYYQTFQIHERTHTGEKPYQCKQC-GKALSCPTSFRSHERIHTGEKPykckkcgKAFSFPS 321
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 322 SFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHTGNGPYKCKECGKAFDCPSSFQIHERTHTGEKPYECKQC---- 397
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESprss 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 398 -GKAFSCSSSF-RMHERTHTG-EKPHECKQCGKAFSCSSSVRIHERT--HTGE--KPYEC--KQCGKAFSCSSSFRMHER 468
Cdd:COG5048 265 lPTASSQSSSPnESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 469 IHTGEKPYECK--QCGKAFSFSS-----SFRMHERTHTGEKPYEC--KQCGKAFSCSSSFRMHERTHTGEKPYECK--QC 537
Cdd:COG5048 345 LHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 22749235 538 GKAFSCSSSIRIHERTHTGEKPYECKQCGKAFSCSSSVRMHE 579
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-635 7.44e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 7.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 222 KPYKCKECGKTFSHPSSFRNHERTHSGEKPYECKQCGKAFRYY--QTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHE 299
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 300 RIHTGE-KPYKCKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFI----SLPSYRRHMIMHTGNGPYKCkecgkafd 374
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSN-------- 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 375 cpSSFQIHERTHTGEKPYECKQCG---KAFSCSSSFRMHERTHTGEKPHECKQCGKAFSCSSSVR----IHERTHTGEKP 447
Cdd:COG5048 184 --LSLLISSNVSTSIPSSSENSPLsssYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSslssSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 448 YECKQcgKAFSCSSSF-RMHERIHTG-EKPYECKQCGKAFSFSSSFRMHERT--HTGE--KPYEC--KQCGKAFSCSSSF 519
Cdd:COG5048 262 RSSLP--TASSQSSSPnESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749235 520 RMHERTHTGEKPYECKQC-------GKAFSCSSSIRIHERTHTGEKPYEC--KQCGKAFSCSSSVRMHERTHTGVKPYEC 590
Cdd:COG5048 340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*..
gi 22749235 591 K--QCDKAFSCSRSFRIHERTHTGEKPYACQQCGKAFKCSRSFRIHE 635
Cdd:COG5048 420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-235 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|..
gi 22749235   214 HMRMHTGEKPYKCKECGKTFSH 235
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   490 SFRMHERTHTGEKPYECKQCGKAFSC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   518 SFRMHERTHTGEKPYECKQCGKAFSC 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   406 SFRMHERTHTGEKPHECKQCGKAFSC 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 3.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.71e-03
                          10        20
                  ....*....|....*....|....*
gi 22749235   294 SFRSHERIHTGEKPYKCKKCGKAFS 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 4.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.51e-03
                          10        20
                  ....*....|....*....|....*
gi 22749235   462 SFRMHERIHTGEKPYECKQCGKAFS 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 5.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   378 SFQIHERTHTGEKPYECKQCGKAFSC 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 6.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   574 SVRMHERTHTGVKPYECKQCDKAFSC 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 71-127 6.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22749235  71 CERKEGSQFG-----------ETISQTPNPKPNKKTFTRVKPYECSVCGKDYMCHSSLNRHmRSHTEH 127
Cdd:COG5189 357 CNKKYKNQNGlkyhmlhghqnQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 6.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   434 SVRIHERTHTGEKPYECKQCGKAFSC 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-178 6.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.30e-03
                          10        20
                  ....*....|....*....|....*
gi 22749235   154 SFRIHERTHTGEKPYKCKQCGKAFS 178
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-627 7.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   602 SFRIHERTHTGEKPYACQQCGKAFKC 627
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-207 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   182 SFQIHERTHTGEKPYECKECGKAFIY 207
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
548-571 7.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.90e-03
                          10        20
                  ....*....|....*....|....
gi 22749235   548 RIHERTHTGEKPYECKQCGKAFSC 571
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 8.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   322 SFRKHERIHTGEKPYDCKECGKAFIS 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-263 8.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   238 SFRNHERTHSGEKPYECKQCGKAFRY 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 8.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 22749235   350 SYRRHMIMHTGNGPYKCKECGKAFDC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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