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Conserved domains on  [gi|22748717|ref|NP_689541|]
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adenylosuccinate synthetase isozyme 1 isoform 2 [Homo sapiens]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-454 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 746.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   115 KNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLILPYHKALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFRE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   195 RFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVT 271
Cdd:pfam00709 156 KLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:pfam00709 235 SSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   352 MVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIR 431
Cdd:pfam00709 315 RINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVE 394
                         410       420
                  ....*....|....*....|...
gi 22748717   432 FVENHVGVAVKWVGVGKSRESMI 454
Cdd:pfam00709 395 FIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-454 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 746.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   115 KNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLILPYHKALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFRE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   195 RFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVT 271
Cdd:pfam00709 156 KLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:pfam00709 235 SSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   352 MVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIR 431
Cdd:pfam00709 315 RINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVE 394
                         410       420
                  ....*....|....*....|...
gi 22748717   432 FVENHVGVAVKWVGVGKSRESMI 454
Cdd:pfam00709 395 FIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
33-454 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 673.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717     33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    113 AEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 192
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    193 SSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYP 268
Cdd:smart00788 152 REKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYP 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    269 FVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILR 348
Cdd:smart00788 231 YVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLR 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    349 YAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQN 428
Cdd:smart00788 311 YAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKK 390
                          410       420
                   ....*....|....*....|....*.
gi 22748717    429 YIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:smart00788 391 YIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
30-454 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 635.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   30 GSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNEKKGlKDWEKRLIISDRAHLVFDFHQAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDF 189
Cdd:PTZ00350  91 LEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQAIDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  190 DEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPF 269
Cdd:PTZ00350 168 ETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPY 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  270 VTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRY 349
Cdd:PTZ00350 247 VTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRY 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  350 AHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 427
Cdd:PTZ00350 327 VQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQ 406
                        410       420
                 ....*....|....*....|....*..
gi 22748717  428 NYIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:PTZ00350 407 KYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
33-456 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 627.04  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 113 AEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 192
Cdd:COG0104  81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 193 SSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTY 267
Cdd:COG0104 156 REKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTY 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 268 PFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMIL 347
Cdd:COG0104 234 PYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVAL 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 348 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 427
Cdd:COG0104 314 RYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENAR 393
                       410       420
                ....*....|....*....|....*....
gi 22748717 428 NYIRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:COG0104 394 AYVERIEELLGVPISIVSVGPDREQTIVR 422
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
32-454 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 529.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 112 EAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfde 191
Cdd:cd03108  81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 192 fssrfknlahqhqsmfptleidiegqlkrlkgfaerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVT 271
Cdd:cd03108 150 --------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVT 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:cd03108 191 SSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAV 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 352 MVNGFTALALTKLDIldvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIR 431
Cdd:cd03108 271 RINGLTELALTKLDV----------------------------------------------------------NAQKYIE 292
                       410       420
                ....*....|....*....|...
gi 22748717 432 FVENHVGVAVKWVGVGKSRESMI 454
Cdd:cd03108 293 RIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
35-456 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 512.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   115 KNEKkGLKDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDE 191
Cdd:TIGR00184  81 YLEK-RGISVRDRLFVSYRCHLILPYHKKLDKARE---KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   192 FSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVT 271
Cdd:TIGR00184 157 AKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:TIGR00184 236 SSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYAC 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   352 MVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIR 431
Cdd:TIGR00184 316 RLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIE 395
                         410       420
                  ....*....|....*....|....*
gi 22748717   432 FVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:TIGR00184 396 RIEELTGVPVTIISTGPEREQTIDL 420
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
33-355 5.19e-27

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 109.77  E-value: 5.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQ-GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGL 109
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNEKKGLkDWEKRLIISDRAHLvfdfhqaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdf 189
Cdd:NF038379  81 REEIEELEDAGH-DVGKRLLIHEQATV-------IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN----------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  190 defssrfknlahqhqsmfPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPF 269
Cdd:NF038379 142 ------------------PSTLGDAEGDFGEGAVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPY 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  270 VTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKAYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRR 338
Cdd:NF038379 204 CTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRR 275
                        330
                 ....*....|....*..
gi 22748717  339 CGWLDLMILRYAHMVNG 355
Cdd:NF038379 276 VGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-454 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 746.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   115 KNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLILPYHKALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFRE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   195 RFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVT 271
Cdd:pfam00709 156 KLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYVT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:pfam00709 235 SSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   352 MVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIR 431
Cdd:pfam00709 315 RINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVE 394
                         410       420
                  ....*....|....*....|...
gi 22748717   432 FVENHVGVAVKWVGVGKSRESMI 454
Cdd:pfam00709 395 FIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
33-454 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 673.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717     33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    113 AEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 192
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEVL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    193 SSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYP 268
Cdd:smart00788 152 REKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTYP 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    269 FVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILR 348
Cdd:smart00788 231 YVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLR 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    349 YAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQN 428
Cdd:smart00788 311 YAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKK 390
                          410       420
                   ....*....|....*....|....*.
gi 22748717    429 YIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:smart00788 391 YIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
30-454 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 635.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   30 GSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNEKKGlKDWEKRLIISDRAHLVFDFHQAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDF 189
Cdd:PTZ00350  91 LEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQAIDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-NF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  190 DEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPF 269
Cdd:PTZ00350 168 ETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYPY 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  270 VTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRY 349
Cdd:PTZ00350 247 VTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRY 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  350 AHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 427
Cdd:PTZ00350 327 VQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQ 406
                        410       420
                 ....*....|....*....|....*..
gi 22748717  428 NYIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:PTZ00350 407 KYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
33-456 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 627.04  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 113 AEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 192
Cdd:COG0104  81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEVL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 193 SSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGTY 267
Cdd:COG0104 156 REKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGTY 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 268 PFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMIL 347
Cdd:COG0104 234 PYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVAL 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 348 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 427
Cdd:COG0104 314 RYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENAR 393
                       410       420
                ....*....|....*....|....*....
gi 22748717 428 NYIRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:COG0104 394 AYVERIEELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
32-456 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 612.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:PRK01117   2 KNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  112 EAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEVQRqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLsDFD 190
Cdd:PRK01117  82 EIDELEARGV-DVRERLRISERAHLILPYHRALDKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  191 EFSSRFKNLAHQH----QSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFG 265
Cdd:PRK01117 156 TFAEKLEENLEYKnfllTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDIDHG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  266 TYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLM 345
Cdd:PRK01117 234 TYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAV 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  346 ILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQ 425
Cdd:PRK01117 314 ALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPEN 393
                        410       420       430
                 ....*....|....*....|....*....|.
gi 22748717  426 AQNYIRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:PRK01117 394 ARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
PLN02513 PLN02513
adenylosuccinate synthase
31-454 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 597.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   31 SRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVV-VDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PLN02513   2 SQVSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEVQRqaqEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDF 189
Cdd:PLN02513  82 FEEIDGLESNGV-SCEGRLLVSDRAHLLFDFHQEVDGLREAEL---AGSKIGTTKRGIGPAYSSKATRNGLRVGDLR-HM 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  190 DEFSSRFKNLAHQHQSMFPTLEID---IEGQLKRLKGFAERIRPMVRDGVYFMYEAlHGPPKKILVEGANAALLDIDFGT 266
Cdd:PLN02513 157 DTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFGT 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  267 YPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMI 346
Cdd:PLN02513 236 YPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVA 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  347 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL-NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQ 425
Cdd:PLN02513 316 LKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAA 395
                        410       420
                 ....*....|....*....|....*....
gi 22748717  426 AQNYIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:PLN02513 396 AQAYVERIEELVGVPVHYIGVGPGRDALI 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
32-454 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 529.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 112 EAEKNEKKGLkDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfde 191
Cdd:cd03108  81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD------- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 192 fssrfknlahqhqsmfptleidiegqlkrlkgfaerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFVT 271
Cdd:cd03108 150 --------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYVT 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:cd03108 191 SSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAV 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717 352 MVNGFTALALTKLDIldvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYIR 431
Cdd:cd03108 271 RINGLTELALTKLDV----------------------------------------------------------NAQKYIE 292
                       410       420
                ....*....|....*....|...
gi 22748717 432 FVENHVGVAVKWVGVGKSRESMI 454
Cdd:cd03108 293 RIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
35-456 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 512.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717    35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   115 KNEKkGLKDWEKRLIISDRAHLVFDFHQAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FDE 191
Cdd:TIGR00184  81 YLEK-RGISVRDRLFVSYRCHLILPYHKKLDKARE---KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAEK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   192 FSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFVT 271
Cdd:TIGR00184 157 AKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYVT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAH 351
Cdd:TIGR00184 236 SSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYAC 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   352 MVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIR 431
Cdd:TIGR00184 316 RLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIE 395
                         410       420
                  ....*....|....*....|....*
gi 22748717   432 FVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:TIGR00184 396 RIEELTGVPVTIISTGPEREQTIDL 420
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
34-456 4.37e-128

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 377.76  E-value: 4.37e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   34 TVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEA 113
Cdd:PRK13787   4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEEC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  114 EKNEKKGLKDWEKrLIISDRAHLVFDFHQAVDGLQEVQrQAQEGKnIGTTKKGIGPTYSSKAARTGLRICDLLSDfdEFS 193
Cdd:PRK13787  84 DRLQKEGFPVKDK-LLLSDACHLLFPYHSQIDSARETT-SSQEHK-IGTTKKGIGICYADKMMRTGLRVGDLLDK--SYK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  194 SRFKNLAH-------QHQSMFPTLEIDIEgqlKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGT 266
Cdd:PRK13787 159 RRLKHLVDeknreldKLYGMPPVSYNDIN---DGLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFGT 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  267 YPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMI 346
Cdd:PRK13787 235 YPYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEM 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  347 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPAnqEMLQKVEVEYETLPGWKADTTGARRWEDLPPQA 426
Cdd:PRK13787 315 LKHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKC 392
                        410       420       430
                 ....*....|....*....|....*....|
gi 22748717  427 QNYIRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:PRK13787 393 KNYISALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
34-455 3.01e-120

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 357.57  E-value: 3.01e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   34 TVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVsFIGNGVVIHLPGLFEEA 113
Cdd:PRK13786   3 TIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  114 EKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQegknIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFS 193
Cdd:PRK13786  82 DMLEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKERLM 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  194 SRFKNLAHQHQSMFPTLEIDI-----EGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYP 268
Cdd:PRK13786 157 RRLEELAPQKEKEIKELGGDPsivrdEALIDKYLELGRQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGTQK 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  269 FVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILR 348
Cdd:PRK13786 236 FVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLK 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  349 YAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQN 428
Cdd:PRK13786 316 KAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARN 395
                        410       420
                 ....*....|....*....|....*..
gi 22748717  429 YIRFVENHVGVAVKWVGVGKSRESMIQ 455
Cdd:PRK13786 396 YVERLEELMGVPIKYISVGPGREQTFK 422
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
35-456 3.12e-119

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 354.41  E-value: 3.12e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  115 KNEKKGlKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRqaqeGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDfDEFSS 194
Cdd:PRK13783  84 ELKEKF-PDYSGRIFISELAHVVLPVHKELDEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKLRE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  195 RFKNLAHQHQSMFpTLEIDIEGQLKRLKGFAERIRPMVRDGVYfMYEALHGppKKILVEGANAALLDIDFGTYPFVTSSN 274
Cdd:PRK13783 158 FLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPVE-IKRILEE--KSVLFEGTQGVLLDLDVGTYPYVTSSN 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  275 CTVGGVCTGLGIPPQnIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVN 354
Cdd:PRK13783 234 CSTTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVS 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  355 GFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYfPANQEMLQKVEVEYETLPGWKadTTGARRWEDlppqaqnYIRFVE 434
Cdd:PRK13783 313 GVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVRD-PSSLRDLEKAEPVYEEFDGWK--SLEDKNFLK-------FVDFIE 382
                        410       420
                 ....*....|....*....|..
gi 22748717  435 NHVGVAVKWVGVGKSRESMIQL 456
Cdd:PRK13783 383 RETGRKIAYISTGPKIEEIVEV 404
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
36-451 9.12e-117

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 347.95  E-value: 9.12e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   36 VLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEK 115
Cdd:PRK13788   6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEEREN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  116 NEKKGLkdwEKRLIISDRAHLVFDFHQAVDGlqevqrqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLSD--FDEF 192
Cdd:PRK13788  86 LRAGGL---NPKLLISERAHLVLPHHKYVDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDLLDEavLRER 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  193 SSRFknLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEAL-HGppKKILVEGANAALLDIDFGTYPFVT 271
Cdd:PRK13788 153 VERL--LEAKPNSTREAGWDTVEKALADLAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYVT 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  272 SSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRG----HEWGVTTGRKRRCGWLDLMIL 347
Cdd:PRK13788 229 SSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  348 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKripyfpanqemlqkveVEYETLPGWkADTTGARRWEDLPPQAQ 427
Cdd:PRK13788 309 KYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDGQ----------------PVYKELPGW-GDLDGVKSREALPKEAQ 371
                        410       420
                 ....*....|....*....|....
gi 22748717  428 NYIRFVENHVGVAVKWVGVGKSRE 451
Cdd:PRK13788 372 AYLELIEETTGVPVVMFSTSPRRE 395
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
33-456 9.59e-109

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 329.03  E-value: 9.59e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   33 VTVVlGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKaVSFIGNGVVIHLPGLFEE 112
Cdd:PRK13785   3 VTIV-GSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  113 AEKNEKKGLkDWEKRliISDRAHLVFDFHQAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 192
Cdd:PRK13785  81 IDALRERGL-DPDVR--VAERAHVILPYHRVLDGIEE-EAKSDSDLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPDVL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  193 SSRFKNLAHQHQSMFPTL----------EIDIEGQLKRLKGFAERIRP--MVRDGVYFMYEALHGPpKKILVEGANAALL 260
Cdd:PRK13785 156 RDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDG-DNVMLEGAQGTSI 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  261 DIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGD--VYGVVKAYTTRVGIGAFPTE---------------QINEIGGLLQ 323
Cdd:PRK13785 235 DIDHGNYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATYIR 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  324 TRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEY 403
Cdd:PRK13785 315 EEGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNF 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 22748717  404 ETLPGWKA---DTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:PRK13785 395 RSFDGWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVL 450
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
35-454 1.03e-93

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 289.61  E-value: 1.03e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:PRK13784   5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  115 KNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLqevqRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFSS 194
Cdd:PRK13784  85 RLQAKGIAISAENLFVSESCTIITSYHKLLDAV----RESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLF-DKDLLRS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  195 RFKNLAHQHQSMF--------PTLEIDIEgqlkRLKGFAERIRPMVRDGVYFMYEALhGPPKKILVEGANAALLDIDFGT 266
Cdd:PRK13784 160 RLAISLAEKETLFrdlykveyPTLEQEFD----KLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDVDYGT 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  267 YPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMI 346
Cdd:PRK13784 235 YPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPL 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  347 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIpYFPANQEMLQKVEVEYETLPGWKADTTGARrwEDLPPQA 426
Cdd:PRK13784 315 LKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEI-YCAYPGIDLYKVEPILVEMEPFSIDETVTK--DNMPAAL 391
                        410       420
                 ....*....|....*....|....*...
gi 22748717  427 QNYIRFVENHVGVAVKWVGVGKSRESMI 454
Cdd:PRK13784 392 KTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
33-456 5.11e-64

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 209.74  E-value: 5.11e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   33 VTVVLGAQWGDEGKGKVVDLLA-TD-ADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLF 110
Cdd:PRK04293   3 CTIVVGGFFGDEGKGKIIAYLAlKDkPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  111 EEAEKNEKKGlkdwekRLIISDRAHLVFDFHQAVDglqevQRQAQEGKNIGTTKKGIGPTYSSKAARTGlricDLLSDFD 190
Cdd:PRK04293  83 KEVEELNVGG------RVFVDYRCGIIEEKHVEED-----RSDEHLSKKIGSTGTGCGPANADRVLRRL----KLAKDVE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  191 EfssrfknlahqhqsmfptleidiegqlkrlkgfaerIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 270
Cdd:PRK04293 148 E------------------------------------LEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYYGTYPYV 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  271 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGgllQTRG-HEWGVTTGRKRRCGWLDLMILRY 349
Cdd:PRK04293 191 TSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEA---EKLGlVEYGTVTGRRRRVGPFDFELARR 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  350 AHMVNGFTALALTKLDILDvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkADTTGARRWEDLPPQAQNY 429
Cdd:PRK04293 268 AARINGATQIAITKLDKLD------------------------------------------KEAYGVTEYDKLPPEAKKF 305
                        410       420
                 ....*....|....*....|....*..
gi 22748717  430 IRFVENHVGVAVKWVGVGKSRESMIQL 456
Cdd:PRK04293 306 IEEIEEELGVPVTLISTGPELEDTIDL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
33-355 5.19e-27

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 109.77  E-value: 5.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQ-GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGL 109
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNEKKGLkDWEKRLIISDRAHLvfdfhqaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsdf 189
Cdd:NF038379  81 REEIEELEDAGH-DVGKRLLIHEQATV-------IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN----------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  190 defssrfknlahqhqsmfPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPF 269
Cdd:NF038379 142 ------------------PSTLGDAEGDFGEGAVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYPY 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  270 VTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKAYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKRR 338
Cdd:NF038379 204 CTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVRR 275
                        330
                 ....*....|....*..
gi 22748717  339 CGWLDLMILRYAHMVNG 355
Cdd:NF038379 276 VGTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
33-197 8.57e-13

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 70.47  E-value: 8.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717   33 VTVVLGAQWGDEGKGKVVDLLATD--ADIISRCQGGNNAGHTVVVD-GKEYDFHLLPSGIINTKAVSFIGNGVVIHlPGL 109
Cdd:PTZ00351 171 VIMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMD-PVS 249
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748717  110 FEEAEKNE--KKGLkDWEKRLIISDRAhLVFDFHQAVDGLQEVQRQaqegknigTTKKGIGPTYSSKAARTGLRICDLLS 187
Cdd:PTZ00351 250 FMEKEIIQliDAGI-DYRDRLFIGNVC-IVTPYHKLLDLLGSAANS--------STLKGMAPVHGSKVMKRGIRLDHIFN 319
                        170
                 ....*....|
gi 22748717  188 DFDEFSSRFK 197
Cdd:PTZ00351 320 DDETLRKRLE 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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