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Conserved domains on  [gi|56847620|ref|NP_689478|]
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transcription factor BTF3 homolog 4 isoform 1 [Homo sapiens]

Protein Classification

nascent polypeptide-associated complex subunit family protein( domain architecture ID 15349547)

nascent polypeptide-associated complex (NAC) subunit beta family protein similar to transcription factor BTF3 that is associated with NACA to prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER)

CATH:  2.20.70.30
Gene Ontology:  GO:0005854|GO:0003723
PubMed:  12475173|26428578|10219998

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAC_BTF3 cd22055
basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role ...
 4-120 3.01e-75

basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role in the transcriptional regulation linked to growth and development in eukaryotes. In mammals, the BTF3 gene encodes two alternative splicing isoforms, BTF3a and BTF3b. The full length BTF3a protein excites transcription. The shortened BTF3b, which lacks the first 44 amino-terminal extension, is a component of the nascent polypeptide-associated complex (NAC), involved in regulating protein localization during translation. BTF3 is involved in oncogenesis; overexpression of BTF3 has been shown to be associated with a variety of malignancies such as cancer of the colon, pancreas, stomach, prostate and breast. It is upregulated in hypopharyngeal squamous cell carcinoma (HSCC) tumors correlating with lymph node metastasis and tumor promotion, thus indicating that BTF3 is a potential therapeutic target and prognostic biomarker for HSCC. BTF3 has also been implicated in the pathogenesis of osteosarcoma (OS), a malignant cancer that affects rapidly proliferating bones, and has a poor prognosis.


:

Pssm-ID: 409234 [Multi-domain]  Cd Length: 117  Bit Score: 220.12  E-value: 3.01e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56847620   4 EKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTF 83
Cdd:cd22055   1 EKLAKLQAAVRIGGKGTPRRKKKVVHKTATTDDKKLQSTLKKLGVQPIPGIEEVNMFKDDGTVIHFNNPKVQASIAANTF 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56847620  84 AITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQF 120
Cdd:cd22055  81 VISGKPETKTLTELLPGILNQLGPENLDNLKKLAEQF 117
 
Name Accession Description Interval E-value
NAC_BTF3 cd22055
basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role ...
 4-120 3.01e-75

basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role in the transcriptional regulation linked to growth and development in eukaryotes. In mammals, the BTF3 gene encodes two alternative splicing isoforms, BTF3a and BTF3b. The full length BTF3a protein excites transcription. The shortened BTF3b, which lacks the first 44 amino-terminal extension, is a component of the nascent polypeptide-associated complex (NAC), involved in regulating protein localization during translation. BTF3 is involved in oncogenesis; overexpression of BTF3 has been shown to be associated with a variety of malignancies such as cancer of the colon, pancreas, stomach, prostate and breast. It is upregulated in hypopharyngeal squamous cell carcinoma (HSCC) tumors correlating with lymph node metastasis and tumor promotion, thus indicating that BTF3 is a potential therapeutic target and prognostic biomarker for HSCC. BTF3 has also been implicated in the pathogenesis of osteosarcoma (OS), a malignant cancer that affects rapidly proliferating bones, and has a poor prognosis.


Pssm-ID: 409234 [Multi-domain]  Cd Length: 117  Bit Score: 220.12  E-value: 3.01e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56847620   4 EKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTF 83
Cdd:cd22055   1 EKLAKLQAAVRIGGKGTPRRKKKVVHKTATTDDKKLQSTLKKLGVQPIPGIEEVNMFKDDGTVIHFNNPKVQASIAANTF 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56847620  84 AITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQF 120
Cdd:cd22055  81 VISGKPETKTLTELLPGILNQLGPENLDNLKKLAEQF 117
NAC pfam01849
NAC domain;
38-90 2.07e-24

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 89.06  E-value: 2.07e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56847620    38 KLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAE 90
Cdd:pfam01849   1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAE 53
 
Name Accession Description Interval E-value
NAC_BTF3 cd22055
basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role ...
 4-120 3.01e-75

basal transcription factor BTF3; Basal transcription factor 3 (BTF3) plays an important role in the transcriptional regulation linked to growth and development in eukaryotes. In mammals, the BTF3 gene encodes two alternative splicing isoforms, BTF3a and BTF3b. The full length BTF3a protein excites transcription. The shortened BTF3b, which lacks the first 44 amino-terminal extension, is a component of the nascent polypeptide-associated complex (NAC), involved in regulating protein localization during translation. BTF3 is involved in oncogenesis; overexpression of BTF3 has been shown to be associated with a variety of malignancies such as cancer of the colon, pancreas, stomach, prostate and breast. It is upregulated in hypopharyngeal squamous cell carcinoma (HSCC) tumors correlating with lymph node metastasis and tumor promotion, thus indicating that BTF3 is a potential therapeutic target and prognostic biomarker for HSCC. BTF3 has also been implicated in the pathogenesis of osteosarcoma (OS), a malignant cancer that affects rapidly proliferating bones, and has a poor prognosis.


Pssm-ID: 409234 [Multi-domain]  Cd Length: 117  Bit Score: 220.12  E-value: 3.01e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56847620   4 EKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTF 83
Cdd:cd22055   1 EKLAKLQAAVRIGGKGTPRRKKKVVHKTATTDDKKLQSTLKKLGVQPIPGIEEVNMFKDDGTVIHFNNPKVQASIAANTF 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56847620  84 AITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQF 120
Cdd:cd22055  81 VISGKPETKTLTELLPGILNQLGPENLDNLKKLAEQF 117
NAC pfam01849
NAC domain;
38-90 2.07e-24

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 89.06  E-value: 2.07e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 56847620    38 KLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAE 90
Cdd:pfam01849   1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAE 53
NAC cd21114
NAC domain; This family contains the NAC domain, named after the nascent ...
 51-93 2.53e-12

NAC domain; This family contains the NAC domain, named after the nascent polypeptide-associated complex (NAC) whose subunits contain NAC domains. In eukaryotes, the NAC complex, which plays an important role in co-translational targeting of nascent polypeptides to endoplasmic reticulum (ER), consists of 2 subunits: NAC alpha and a shortened splice variant of the basal transcription factor 3 (BTF3; also called BTF3b or NAC beta). The full length BTF3a protein excites transcription.


Pssm-ID: 409232  Cd Length: 43  Bit Score: 58.08  E-value: 2.53e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 56847620  51 IAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKP 93
Cdd:cd21114   1 IPGIEEVTMVMEDGSVIVFTMPKVQASLASNVFVVTGEATREQ 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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