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Conserved domains on  [gi|312596924|ref|NP_671692|]
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proteasome assembly chaperone 2 isoform 2 [Homo sapiens]

Protein Classification

PAC2 family protein( domain architecture ID 10561008)

PAC2 family protein similar to vertebrate chaperone protein proteasome assembly chaperone 2 (PAC2), which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1

CATH:  3.40.50.10900
Gene Ontology:  GO:0043248|GO:0051131
PubMed:  18786393
SCOP:  4002309

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAC2 pfam09754
PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, ...
 2-92 6.61e-16

PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.


:

Pssm-ID: 462883  Cd Length: 175  Bit Score: 72.64  E-value: 6.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596924    2 DLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSL---PSRKLVALQLRSIFIKYKSkpFCEKLLSW 78
Cdd:pfam09754  17 DHLIEELEAEEVGEIDSDYLFPYRGRRPVVTFDEGGVREWPPLRLYAVrdpGGRDLLLLQGPEPDLQWER--FAEAVLDW 94

                          90
                  ....*....|....
gi 312596924   79 VKSSGCARVIVLSS 92
Cdd:pfam09754  95 AERLGVKEVVTLGG 108
 
Name Accession Description Interval E-value
PAC2 pfam09754
PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, ...
 2-92 6.61e-16

PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.


Pssm-ID: 462883  Cd Length: 175  Bit Score: 72.64  E-value: 6.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596924    2 DLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSL---PSRKLVALQLRSIFIKYKSkpFCEKLLSW 78
Cdd:pfam09754  17 DHLIEELEAEEVGEIDSDYLFPYRGRRPVVTFDEGGVREWPPLRLYAVrdpGGRDLLLLQGPEPDLQWER--FAEAVLDW 94

                          90
                  ....*....|....
gi 312596924   79 VKSSGCARVIVLSS 92
Cdd:pfam09754  95 AERLGVKEVVTLGG 108
COG1938 COG1938
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
4-91 4.01e-06

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 441541  Cd Length: 236  Bit Score: 46.39  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596924   4 IISTLNMSKIGYFYTDCLVPMVgnnpyaTTEGNSTELSInaEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSG 83
Cdd:COG1938   27 LIETLDMEEVGSIDSDELPPVV------TFEDGRPRPPL--RLYANEDRDVLLLVGDVPEPPRRWEEFAAAVLDWAEELG 98


                 ....*...
gi 312596924  84 CARVIVLS 91
Cdd:COG1938   99 VSEVVSLG 106
 
Name Accession Description Interval E-value
PAC2 pfam09754
PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, ...
 2-92 6.61e-16

PAC2 family; This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.


Pssm-ID: 462883  Cd Length: 175  Bit Score: 72.64  E-value: 6.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596924    2 DLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSL---PSRKLVALQLRSIFIKYKSkpFCEKLLSW 78
Cdd:pfam09754  17 DHLIEELEAEEVGEIDSDYLFPYRGRRPVVTFDEGGVREWPPLRLYAVrdpGGRDLLLLQGPEPDLQWER--FAEAVLDW 94

                          90
                  ....*....|....
gi 312596924   79 VKSSGCARVIVLSS 92
Cdd:pfam09754  95 AERLGVKEVVTLGG 108
COG1938 COG1938
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
4-91 4.01e-06

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 441541  Cd Length: 236  Bit Score: 46.39  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596924   4 IISTLNMSKIGYFYTDCLVPMVgnnpyaTTEGNSTELSInaEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSG 83
Cdd:COG1938   27 LIETLDMEEVGSIDSDELPPVV------TFEDGRPRPPL--RLYANEDRDVLLLVGDVPEPPRRWEEFAAAVLDWAEELG 98


                 ....*...
gi 312596924  84 CARVIVLS 91
Cdd:COG1938   99 VSEVVSLG 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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