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Conserved domains on  [gi|22128751|ref|NP_667330|]
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olfactory receptor family 51 subfamily AI member 2 [Mus musculus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 29-303 5.53e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 439.63  E-value: 5.53e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 29-303 5.53e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 439.63  E-value: 5.53e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 39-312 6.61e-96

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 284.78  E-value: 6.61e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751    39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTSPLVHI 278
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQI 244

                         250       260       270
                  ....*....|....*....|....*....|....
gi 22128751   279 LMGTVSVLFPPVMNPVIYSIKTQQIRRAIVKVIS 312
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 29-303 5.53e-157

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 439.63  E-value: 5.53e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15222   1 HWISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15222  81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15222 161 MKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15222 241 GKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 29-303 3.50e-103

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 303.06  E-value: 3.50e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15917 241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 39-312 6.61e-96

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 284.78  E-value: 6.61e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751    39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTSPLVHI 278
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQI 244

                         250       260       270
                  ....*....|....*....|....*....|....
gi 22128751   279 LMGTVSVLFPPVMNPVIYSIKTQQIRRAIVKVIS 312
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-303 1.16e-94

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 281.54  E-value: 1.16e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15951  81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15951 161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15951 241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 29-303 1.53e-93

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 278.76  E-value: 1.53e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15953   1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15953  81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15953 161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15953 241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 28-304 2.03e-93

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 278.71  E-value: 2.03e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  28 HHWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHF 107
Cdd:cd15948   1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 108 LHSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQD 187
Cdd:cd15948  81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 188 MIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHR 267
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 268 FGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIR 304
Cdd:cd15948 241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 30-303 1.33e-88

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 266.08  E-value: 1.33e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15221   2 WISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15221  82 FVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFG 269
Cdd:cd15221 162 RLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15221 242 RHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 29-307 2.96e-86

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 260.30  E-value: 2.96e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15223   1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDM 188
Cdd:cd15223  81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF 268
Cdd:cd15223 161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRF 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15223 241 GKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 30-303 4.91e-85

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 256.96  E-value: 4.91e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15950   2 WIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15950  82 SFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFG 269
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15950 242 QGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 30-303 2.46e-84

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 255.38  E-value: 2.46e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15952   2 WIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15952  82 TFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIA 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLaMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFG 269
Cdd:cd15952 162 KLACASIRINIIYGLFAISV-LVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15952 241 HNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 14-304 1.03e-82

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 251.62  E-value: 1.03e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  14 AIFLLTGFPGLEWAHHWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDA 93
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  94 RMVGLVPCVLQQHFLHSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYC 173
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 174 HPGALSHAYCLHQDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVL 253
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22128751 254 CFYVPVLGLSIVHRFGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIR 304
Cdd:cd15949 242 AFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 30-303 2.70e-75

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 232.45  E-value: 2.70e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFG 269
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15956 242 HSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 29-303 2.69e-74

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 229.66  E-value: 2.69e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15955   1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAA-ITAAPSLHLLTFDYCHPGALSHAYCLHQD 187
Cdd:cd15955  81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVlIIPCPLLIKLRLHHFRSTVISHSYCEHMA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 188 MIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHR 267
Cdd:cd15955 161 VVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHR 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 268 FGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15955 241 FGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 30-303 9.05e-71

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 220.85  E-value: 9.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15954   2 WISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRF- 268
Cdd:cd15954 162 KLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFg 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQI 303
Cdd:cd15954 242 GHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 39-299 1.70e-55

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 181.14  E-value: 1.70e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd13954  11 YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd13954  91 LAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIvhRFGQHTSPLVHI 278
Cdd:cd13954 171 NELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYV--RPSSSYSSDLDK 248

                       250       260
                ....*....|....*....|.
gi 22128751 279 LMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd13954 249 VVSVFYTVVTPMLNPIIYSLR 269
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 39-307 7.56e-44

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 151.22  E-value: 7.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15235  12 YLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15235  92 LAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSI--VHRFGQHTSPLV 276
Cdd:cd15235 172 NELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFqpSSSYSADKDRVA 251

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128751 277 HILMGTVSvlfpPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15235 252 TVMYTVVT----PMLNPFIYSLRNKDVKGAL 278
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 31-307 3.86e-42

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 147.03  E-value: 3.86e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHS 110
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 111 FSFMESAVLFAMALDRLIAIRFPLRYASVLTGP---RVALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQD 187
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKvclQLAAASWLCGFLNSAVHTVLTFRL---SFCGSNQISHFFCDIPP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 188 MIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYV--------PV 259
Cdd:cd15231 160 LLKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGtaifnynrPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22128751 260 LGLSIvhrfgqHTSPLVHILMGTVSvlfpPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15231 240 SGYSL------DKDTLISVLYSIVT----PMLNPIIYSLRNKEVKGAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 30-299 4.73e-42

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 146.36  E-value: 4.73e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTgPRVALIGTVLGMRSAAITAAPSLHLL-TFDYCHPGALSHAYCLHQDM 188
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMT-PKLCTQLAAGCWLCGFLGPVPEIILIsTLPFCGPNQIQHIFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 IRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIvhRF 268
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYL--RL 238

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15914 239 SKSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 39-307 1.66e-40

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 142.59  E-value: 1.66e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15225  11 YLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRY--------------ASVLTGPRVALIGTVLgmrsaaitaapslhLLTFDYCHPGALSHAYCL 184
Cdd:cd15225  91 LAAMAYDRYVAICNPLRYtlimnrrvclqlvaGSWLSGILVSLGQTTL--------------IFSLPFCGSNEINHFFCD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 185 HQDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVlglSI 264
Cdd:cd15225 157 IPPVLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCA---SF 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22128751 265 VH-RFGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15225 234 TYlRPKSSYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 39-299 2.95e-40

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 141.60  E-value: 2.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15918  11 YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15918  91 LAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTSP-LVH 277
Cdd:cd15918 171 NELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKdSVA 250

                       250       260
                ....*....|....*....|..
gi 22128751 278 ILMGTVsvlFPPVMNPVIYSIK 299
Cdd:cd15918 251 AVMYTV---VTPMLNPFIYSLR 269
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 34-309 1.95e-39

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 139.70  E-value: 1.95e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  34 PIFMG-YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFS 112
Cdd:cd15417   5 VLFLGiYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 113 FMESAVLFAMALDRLIAIRFPLRYASVLTGPR-VALIGT--VLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMI 189
Cdd:cd15417  85 LTECFLLAAMAYDRYVAICNPLLYSVIMSPRLcVQLVAGayLGGFLNSLIQTVSMFQL---SFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRFG 269
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGT--GLFVYLRPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15417 240 SSHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 16-304 2.50e-39

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 139.76  E-value: 2.50e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  16 FLLTGFPGlewaHHWISLPIFMG----YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWF 91
Cdd:cd15408   1 FILLGFTD----QPELQVLLFVVflliYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  92 DARMVGLVPCVLQQHFLHSFSFMESAVLFAMALDRLIAIRFPLRYaSVLTGPRV--ALIGT--VLGMRSAAITAAPSLHL 167
Cdd:cd15408  77 ERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLY-TVIMSQRVcvSLVAGsyLAGFLNSTVHTGFILRL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 168 ltfDYCHPGALSHAYCLHQDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVS 247
Cdd:cd15408 156 ---SFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCAS 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 248 HILAVLCFYVpvlglSIVHRFGQHTSPLVHILMGTVSVLFP---PVMNPVIYSIKTQQIR 304
Cdd:cd15408 233 HLTAVTLFYG-----SLAFMYLRPSSRYSLDLDKVASVFYTvviPMLNPLIYSLRNKEVK 287
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 35-306 8.26e-39

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 138.07  E-value: 8.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15421   7 ILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYaSVLTGPRVALIGTV----LGMRSAAITAAPSLHlltFDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15421  87 ECLLLALMAYDRYVAICHPLRY-PVLMSPRVCLLMAAgswlGGSLNSLIHTVYTMH---FPYCGSREIHHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRF--NRLYGLCIIMLAMgsDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRF 268
Cdd:cd15421 163 LSCADTSAyeTVVYVSGVLFLLI--PFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGP--AIFTYMRP 238

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128751 269 GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRA 306
Cdd:cd15421 239 GSYHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 39-306 5.44e-38

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 135.92  E-value: 5.44e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15420  11 YIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRVALIGTVLGMRSAAITAAPSLHL-LTFDYCHPGALSHAYCLHQDMIRLACSDTR 197
Cdd:cd15420  91 LAVMSYDRYVAICHPLRY-TVIMNWRVCTTLAATSWACGFLLALVHVVLlLRLPFCGPNEVNHFFCEILAVLKLACADTW 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 198 FNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTSPLVH 277
Cdd:cd15420 170 INEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKI 249

                       250       260
                ....*....|....*....|....*....
gi 22128751 278 ILMgtVSVLFPPVMNPVIYSIKTQQIRRA 306
Cdd:cd15420 250 LSL--FYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 16-311 2.12e-37

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 135.09  E-value: 2.12e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  16 FLLTGFPGlewaHHWISLPIFMG----YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWF 91
Cdd:cd15410   1 FILLGFTD----YPELQVPLFLVflaiYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  92 DARMVGLVPCVLQQHFLHSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIgtVLGMRSAAITAAPSLHLLTFD 171
Cdd:cd15410  77 EDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLL--VAGSYLWGIVCSLIHTCGLLR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 172 --YCHPGALSHAYCLHQDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHI 249
Cdd:cd15410 155 lsFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHL 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22128751 250 LAVLCFYVPVLGLSIVhrfgqhtsPLVHILMGTV---SVLFP---PVMNPVIYSIKTQQIRRAIVKVI 311
Cdd:cd15410 235 TAITIFHGTILFMYCR--------PSSSYSLDTDkvaSVFYTvviPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 39-307 2.23e-37

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 134.48  E-value: 2.23e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15228  11 YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRV-ALIGTVLGMRSAaiTAAPSLHLLTFD--YCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15228  91 YTVMAYDRYVAICHPLRY-LLIMNRRVcALLAAGTWITSS--FHATILTSLTFTlpYCGSNVVDYFFCDIFPVLKLACAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLsivhrfgqHTSPL 275
Cdd:cd15228 168 TSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALI--------YTQPT 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 276 VHILMGTV----SVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15228 240 PSPVLVTPvqifNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 39-309 7.43e-37

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 133.29  E-value: 7.43e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15412  11 YLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYM 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGP---RVALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15412  91 LAVMAYDRYMAICNPLLYSVKMSRRvciSLVTFPYIYGFLNGLIQTILTFRL---SFCGSNVINHFYCADPPLIKLSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYvPVLGLSIVHRFGQHT--- 272
Cdd:cd15412 168 TYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFY-GTLFCMYLRPPSEESveq 246

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 273 SPLVHILMGTVSvlfpPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15412 247 SKIVAVFYTFVS----PMLNPLIYSLRNKDVKQALKK 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 35-299 1.06e-36

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 132.36  E-value: 1.06e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15947   7 VLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYAsVLTGPRV----ALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15947  87 ECVLLAVMAFDRYVAVCRPLHYT-VIMHPRLcvqlAALSWLSGLANSLLQTTLTLQL---PLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRFN--RLYGLCIIMLAMgsDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIV--H 266
Cdd:cd15947 163 LACVDTTFNelELFVASVFFLLV--PLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQppS 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128751 267 RFGQHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15947 241 SYSQDQGKFISLFYTVVT----PTLNPLIYTLR 269
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 35-307 1.42e-36

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 132.17  E-value: 1.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15424   7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLTGPR---VALIGTVLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRL 191
Cdd:cd15424  87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWRqlqLALSCWAIGFLLSVINVGCTLRHP---FCGPNHINHFFCELPVVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 192 ACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGqh 271
Cdd:cd15424 164 ACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG-- 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 272 TSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 33-299 1.79e-36

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 131.84  E-value: 1.79e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  33 LPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFS 112
Cdd:cd15912   5 LLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 113 FMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIgtVLG--MRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15912  85 TTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQL--VLGswVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIvhRFGQ 270
Cdd:cd15912 163 LSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYV--RPSQ 240

                       250       260
                ....*....|....*....|....*....
gi 22128751 271 HTSPLVHILMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLR 269
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 39-307 2.22e-36

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 131.93  E-value: 2.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15234  11 YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRVALIGTVLGMRSAAITAAP-SLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTR 197
Cdd:cd15234  91 LAVMAYDRYVAICHPLHY-TVIMNPCLCGLLVLLSLLISILDSLLhSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 198 FNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQ-HTSPLV 276
Cdd:cd15234 170 INNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHsSRKTAV 249

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128751 277 HILMGTVsvlFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15234 250 ASVMYTV---VTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 35-299 1.01e-35

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 129.70  E-value: 1.01e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15237   7 FLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLTGP---RVALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRL 191
Cdd:cd15237  87 ECVLLAVMAYDRYVAICNPLRYSVIMSRRvcvRLAATSWASGFLNSLVLTSLTLRL---PFCGPNHINHFFCEAPAVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 192 ACSDTRFNRL--YGLCIIMLamGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIV--HR 267
Cdd:cd15237 164 ACADTSLNEAviFVTSVLVL--LIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRphST 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128751 268 FGQHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15237 242 HSPDQDKMISVFYTIVT----PMLNPLIYSLR 269
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 39-307 1.27e-35

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 129.64  E-value: 1.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLglCMS--TLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMES 116
Cdd:cd15229  11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDI--CYSsvTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 117 AVLFAMALDRLIAIRFPLRYASVLTGPR-VALIGT--VLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLAC 193
Cdd:cd15229  89 FLLSAMAYDRYAAICHPLHYVQIMSKQVcVQLVGGawALGFLYALINTLLLLNL---HFCGPNEINHFSCELPSLLPLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 194 SDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLgLSIVHRFGQHTS 273
Cdd:cd15229 166 SDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGF-FRYLRPNSASSS 244

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 274 PLVHILMGTVSVLfPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15229 245 VLDRVFSIQYSIL-TPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 39-299 1.36e-35

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 129.55  E-value: 1.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15230  11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTgpRVALIGTVLGMRSAAITAAPSLHLLTF--DYCHPGALSHAYCLHQDMIRLACSDT 196
Cdd:cd15230  91 LAAMAYDRYVAICNPLLYTVIMS--KRVCIQLVAGSYLCGFVNSIVHTSSTFslSFCGSNVINHFFCDIPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 197 RFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLgLSIVHRFGQHTSPLV 276
Cdd:cd15230 169 HINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLI-FMYLRPSSSYSLDQD 247

                       250       260
                ....*....|....*....|....*.
gi 22128751 277 HIlmgtVSV---LFPPVMNPVIYSIK 299
Cdd:cd15230 248 KV----VSVfytVVIPMLNPLIYSLR 269
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 39-307 2.23e-35

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 129.11  E-value: 2.23e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVL-GVLWFDARMVGLVPCVLQQHFLHSFSFMESA 117
Cdd:cd15916  11 YLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFFHFLGSTECF 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 118 VLFAMALDRLIAIRFPLRYASVLTG---PRVALIGTVLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15916  91 LYTLMAYDRYLAICHPLHYPTIMTGrlcTRLATGTWVAGSLHSAIHTSLTFRLP---FCGPNRIDYFFCDIPPLLKLACA 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRFGQHTSp 274
Cdd:cd15916 168 DTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVP--CVFIYLRPGSKEA- 244

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 275 lvhiLMGTVSVLF---PPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15916 245 ----LDGVIAVFYtvvTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 35-309 8.36e-35

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 127.81  E-value: 8.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15419   7 FLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLtgPRVALIGTVLGMRSAAITAAPSLHLLTF--DYCHPGALSHAYCLHQDMIRLA 192
Cdd:cd15419  87 EGFLLAAMAYDRFIAICNPLLYPVIM--SRRVCVQLVAGSYLCGCINSIIQTSFTFslSFCGSNEIDHFFCDVPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 193 CSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHrfGQHT 272
Cdd:cd15419 165 CSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQP--GAVS 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 273 SPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15419 243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 39-299 9.76e-35

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 127.18  E-value: 9.76e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP-SVLGVLWfDARMVGLVPCVLQQHFLHSFSFMESA 117
Cdd:cd15227  11 YLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPkSIANSLT-NTRSISFLGCVAQVFLFIFFAASELA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 118 VLFAMALDRLIAIRFPLRYASVLTgPRV----ALIGTVLGMRSAAITAAPSLHLLTfdyCHPGALSHAYCLHQDMIRLAC 193
Cdd:cd15227  90 LLTVMAYDRYVAICHPLHYEVIMN-RGAcvqmAAASWLSGLLYGALHTANTFSLPF---CGSNVIHQFFCDIPQLLKLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 194 SDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRFGQHTS 273
Cdd:cd15227 166 SDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLST--GSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*.
gi 22128751 274 PLVHILMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLR 269
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 31-307 1.60e-34

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 126.73  E-value: 1.60e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHS 110
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 111 FSFMESAVLFAMALDRLIAIRFPLRYaSVLTGPR----VALIGTVLGMRSAAITAAPSLHLLTfdyCHPGALSHAYCLHQ 186
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHY-TVVMHPRlcwkLVAMSWLIGFGNSLVLSPLTLSLPR---CGHHRVDHFFCEMP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 187 DMIRLACSDTRFNR--LYGLCIIMLAMgsDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSI 264
Cdd:cd15434 159 ALIKLACVDTTAYEatIFALGVFILLF--PLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22128751 265 V--HRFGQHTSPLVHILMGTVsvlfPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15434 237 QpkNSVSQDQGKFLTLFYTIV----TPSLNPLIYTLRNKDVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 35-311 3.62e-34

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 126.32  E-value: 3.62e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15943  21 FLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATT 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYaSVLTGPRVAlIGTVLGMRSAAITAAPSLHLLTF--DYCHPGALSHAYCLHQDMIRLA 192
Cdd:cd15943 101 ECFLLAVMAYDRYVAICNPLLY-TVIMSPRVC-IQLVAGSYLIGFVNALIQTICTFrlPFCGSNVINHFFCDVPPLLKLS 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 193 CSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLsivhrfgqHT 272
Cdd:cd15943 179 CSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFM--------YL 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22128751 273 SPLVHILMG---TVSVLFP---PVMNPVIYSIKTQQIRRAIVKVI 311
Cdd:cd15943 251 RPSSSYSLDqdkVVSVFYTvviPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 39-306 9.19e-34

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 124.82  E-value: 9.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15429  11 YLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFIL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGP---RVALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15429  91 LAVMAYDRYVAVCHPLRYTVIMSGGlciQLAAASWTSGFLNSLVQTAFTFRL---PFCGHNTINHFSCELLAVVRLACVD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRlyglcIIMLAMGSDVL-----FILLSYAVILRTVLAIASAGERLKALNTCVSHILAV-LCFYVPVLGLSivhRFG 269
Cdd:cd15429 168 TSLNE-----VAILVSSVVVLltpcfLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVsLCYGTAIFTYM---RPR 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 270 QHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRA 306
Cdd:cd15429 240 SGSSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 36-307 1.06e-33

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 124.91  E-value: 1.06e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15233   8 LLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGAD 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLT-GPRVALIG-TVLGMRSAAITAAPSLHLLTFdyCHPGALSHAYCLHQDMIRLAC 193
Cdd:cd15233  88 CFLLTAMAYDRYLAICQPLTYSVRMSwRVQTALVGiSCACAFTNALTHTVAMSTLKF--CGPNVINHFFCDLPPLFQLSC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 194 SDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRFGQHTS 273
Cdd:cd15233 166 SSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGT--GVFSYMRLGSVYS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 274 PLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15233 244 SDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 35-309 1.32e-33

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 124.45  E-value: 1.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLglCMSTL--PSVLGVLWFDARMVGLVPCVLQQHFLHSFS 112
Cdd:cd15415   7 FLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDL--CYSSVfaPRLLVNFLVEKKTISYSACIAQHFFFAVFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 113 FMESAVLFAMALDRLIAIRFPLRYASVLtgPRVALIGTVLGMRSAAITAAPS--LHLLTFDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15415  85 TTEGFLLAVMAYDRYVAICNPLLYTVAM--TKRVCVQLVAGSYLGGLINSLThtIGLLKLSFCGPNVINHYFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVlGLSIVHRFGQ 270
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSV-SFSYIQPSSQ 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22128751 271 HTsplvhILMGTVSVLF----PPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15415 242 YS-----LEQEKVSAVFytlvIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 39-309 2.10e-33

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 123.97  E-value: 2.10e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15411  11 YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTgpRVALIGTVLGMRSAAITAA--PSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDT 196
Cdd:cd15411  91 LGLMAYDRYVAICNPLLYTVVMS--RRVCLKLAAGSYAAGFLNSliHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 197 RFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYvpvlGLSIVHRFGQHTSPLV 276
Cdd:cd15411 169 HVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFY----GTGIFTYLRPSSSYSL 244

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 277 HilMGTVSVLF----PPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15411 245 G--QDKVASVFytvvIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 39-297 2.35e-33

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 123.75  E-value: 2.35e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15911  11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGpRVAL---IGTVLGMRSAAITAAPSLHLLTFdyCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15911  91 LAVMSYDRYLAICKPLHYASLMNG-RLCLqlaAGSWISGFLASTITVILMSQLTF--CGPNEIDHFFCDFAPLLKLSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlgLSIVHRFGQHTSPL 275
Cdd:cd15911 168 TSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGT---LIIVYVVPSTNTSR 244

                       250       260
                ....*....|....*....|....*
gi 22128751 276 VhiLMGTVSVL---FPPVMNPVIYS 297
Cdd:cd15911 245 D--LNKVFSLFytvLTPLVNPLIYS 267
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 39-299 4.82e-33

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 122.72  E-value: 4.82e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15431  11 YLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLhLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15431  91 LAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQALLKLACSDTSL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRlyglcIIMLAMGSDVL-----FILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYvpvlGLSIV------HR 267
Cdd:cd15431 170 NE-----ILMFATSIFTLllpfsFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFY----GTAIFmylrpqSK 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128751 268 FGQHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15431 241 SSSDQDKIISVFYGVVT----PMLNPLIYSLR 268
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 35-311 8.61e-33

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 122.48  E-value: 8.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMG-YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLglCMSTL--PSVLGVLWFDARMVGLVPCVLQQHFLHSF 111
Cdd:cd15406  15 LFLGiYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDL--CYSSVitPKMLVNFVSEKNIISYPECMTQLFFFCVF 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 112 SFMESAVLFAMALDRLIAIRFPLRYaSVLTGPRVALIgTVLGMRSAAITAAP--SLHLLTFDYCHPGALSHAYCLHQDMI 189
Cdd:cd15406  93 AIAECYMLTAMAYDRYVAICNPLLY-NVTMSPRVCSL-LVAGVYIMGLIGATvhTSCMLRLSFCGDNVINHYFCDILPLL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVpvlglSIVHRFG 269
Cdd:cd15406 171 KLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYG-----SIIFMYL 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22128751 270 QHTSpLVHILMGTVSVLF----PPVMNPVIYSIKTQQIRRAIVKVI 311
Cdd:cd15406 246 KPSS-SSSMTQEKVSSVFyttvIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 39-299 1.00e-32

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 121.98  E-value: 1.00e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15232  11 YAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15232  91 LTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCI-IMLAMGSdVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIvhRFGQHTSP--- 274
Cdd:cd15232 171 NEIMAFVAdVFFGVGN-FLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYI--RPSSSYSPekd 247

                       250       260
                ....*....|....*....|....*.
gi 22128751 275 -LVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15232 248 kVVAVLYSVVT----PTLNPLIYSLR 269
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 39-307 1.32e-32

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 121.82  E-value: 1.32e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15428  11 YLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECAL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15428  91 LSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRL--YGLCIIMLAMgsDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVlgLSIVHRFGQHTSPLV 276
Cdd:cd15428 171 AEMamFIMCVFTLVL--PVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSV--LSTYMRPKSSTSKEY 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128751 277 HILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15428 247 DKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 36-309 2.12e-32

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 121.36  E-value: 2.12e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15409   8 LAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLTgPRVAL----IGTVLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRL 191
Cdd:cd15409  88 CFLLAAMAYDRYVAICNPLLYPVVMS-NRLCVqlitASYIGGFLHSMIHVGLTFRLS---FCGSNEINHFFCDIPPLLKI 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 192 ACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQH 271
Cdd:cd15409 164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128751 272 TSPlvHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15409 244 LDQ--DMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 39-307 2.30e-32

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 121.00  E-value: 2.30e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15942  11 YLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGpRVAL---IGTVL-GMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15942  91 YTVMAYDRFLAICKPLHYSTIMNH-RACLclsLGTWLgGCLHSTFQTSLTFRL---PYGQKNEVDYIFCDIPAMLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLglsivhrFGQHTSP 274
Cdd:cd15942 167 DTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLT-------FIYLRPG 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 275 LVHILMGTVSVLF---PPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15942 240 SQDPLDGVVAVFYttvTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 39-299 2.39e-32

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 120.87  E-value: 2.39e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15915  11 YLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAML 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRV----ALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15915  91 LAVMAYDRYVAICNPLRY-TVIMNPQVclllAVACWVTGFFHALMHTVMTSRL---PFCGPNKINHFFCDIKPLLKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNrLYGLCII--MLAMGSdVLFILLSYAVILRTVLAIA-SAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGqh 271
Cdd:cd15915 167 DTSLN-LWLLNIVtgSIALGT-FILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG-- 242

                       250       260
                ....*....|....*....|....*...
gi 22128751 272 TSPLVHILMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLR 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 16-309 2.21e-31

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 119.08  E-value: 2.21e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  16 FLLTGF---PGLEWAHHWISLPIfmgYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFD 92
Cdd:cd15945   1 FILLGFtdyLSLKVTLFLVFLLV---YLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  93 ARMVGLVPCVLQQHFLHSFSFMESAVLFAMALDRLIAIRFPLRYAsVLTGPRVALIGTVLGMRSAAITAApsLHL-LTFD 171
Cdd:cd15945  78 RKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYT-TAMSRRVCYLLLVGAYLSGMATSL--VHTtLTFR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 172 YCHPGA--LSHAYCLHQDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHI 249
Cdd:cd15945 155 LSFCGSntINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHL 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 250 LAVLCFYVPVLGLSIvhRFGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15945 235 TAVGLFYGTLLFMYL--RPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 39-299 3.27e-31

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 117.96  E-value: 3.27e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15946  11 YLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGP---RVALIGTVLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15946  91 FSVMAYDRYVAICHPLRYKVIMSWGlciLMVAGSWVCGVFSSLLHTFFTMRL---PYCGPNEINHYFCEVPAVLKLACAD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPvlGLSIVHRFGQHTSPL 275
Cdd:cd15946 168 TSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGP--AMFMYMRPGSNYSPE 245

                       250       260
                ....*....|....*....|....
gi 22128751 276 VHILMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15946 246 RDKKISLFYNVFTALLNPVIYSLR 269
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 35-307 5.97e-31

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 117.58  E-value: 5.97e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15432   7 FLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGST 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15432  87 ECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYvpvlgLSIVHRFGQHTSP 274
Cdd:cd15432 167 DTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFY-----GTAISMYLQPPSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 275 LVHILMGTVSV---LFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15432 242 SSHDRGKMVALfygIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 39-309 6.66e-31

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 117.42  E-value: 6.66e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15413  11 YLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15413  91 LSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHE 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVpvlglSIVHRFGQHTSPlvHI 278
Cdd:cd15413 171 KELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYG-----TLIFMYLQPKSS--HS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128751 279 L----MGTV-SVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15413 244 LdtdkMASVfYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 39-307 9.46e-31

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 116.79  E-value: 9.46e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15236  11 YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIgtVLGMRSAAiTAAPSLHLLTFD---YCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15236  91 LAVMAYDRYVAICHPLHYTAIMRPELCVLL--VAGSWVLT-CFHALLHTLLLArlsFCADNVIPHFFCDLVALLKLSCSS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIvhRFGQHTSPL 275
Cdd:cd15236 168 TSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYF--FPSSNNSSD 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128751 276 VHILMGTVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15236 246 KDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 39-309 1.38e-30

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 116.70  E-value: 1.38e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15416  11 YSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRVAL---IGTVLGMRSAAITAAPSLHLLTFdyCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15416  91 LAAMAYDRYVAICNPLLY-STIMSQKVCVllvAASYLGGCLNALVFTTCVFSLSF--CGPNEINHFFCDFPPLLKLSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVpvlglSIVHRFGQHTSPL 275
Cdd:cd15416 168 IRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYG-----TITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 276 VHILMGTVSVLFP---PVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15416 243 SMDQNKVVSVFYMvviPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 39-311 2.28e-30

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 115.99  E-value: 2.28e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15414  11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYaSVLTGPRVA---LIGT-VLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15414  91 LASMAYDRYVAICNPLLY-TVIMSQRVCvqlVVGPyVVGLLNTTTHTTAAFFLP---FCGPNVINHFFCDIPPLLSLSCA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLYgLCIIMLAMG-SDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVlgLSIVHRFGQHTS 273
Cdd:cd15414 167 DTQINKWV-LFIMAGALGvLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTL--FFIYVRPSSSSS 243

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128751 274 PLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVKVI 311
Cdd:cd15414 244 LDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 35-299 3.93e-30

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 115.11  E-value: 3.93e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15913   7 FSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15913  87 ECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTsp 274
Cdd:cd15913 167 PAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNST-- 244

                       250       260
                ....*....|....*....|....*....
gi 22128751 275 lvhiLMGTVSVLF----PPVMNPVIYSIK 299
Cdd:cd15913 245 ----GMQKIVTLFysvvTPLLNPLIYSLR 269
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 39-307 2.54e-29

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 113.02  E-value: 2.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQ-PMYYFLAILAVTDLGLCMSTLPSVL-GVLWFDARMVGLVPCVLQQHFLHSFSFMES 116
Cdd:cd15941  11 YLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYAFHFLASTEC 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 117 AVLFAMALDRLIAIRFPLRYASVLtGPRVAL----IGTVLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRLA 192
Cdd:cd15941  91 FLYTVMAYDRYLAICHPLHYPTAM-NRRMCAglagGTWATGATHAAIHTSLTFRLP---YCGPCQIAYFFCDIPPVLKLA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 193 CSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHT 272
Cdd:cd15941 167 CADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAG 246

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 273 SPLVHILMGTVSvlfpPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15941 247 AGAPAVFYTIVT----PMLNPFIYTLRNKEVKRAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 33-307 8.74e-29

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 111.74  E-value: 8.74e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  33 LPIF----MGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15405   1 IPLFflflGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTgPRVAL---IGTVLGMRSAAITAAPSLHLLTFdyCHPGALSHAYCLH 185
Cdd:cd15405  81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMS-PQVCSllmLGSYVMGFAGAMAHTGCMLRLTF--CDSNIINHYMCDI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 186 QDMIRLACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYvpvlGLSIV 265
Cdd:cd15405 158 LPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFF----GSGAF 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22128751 266 HRFgqHTSPLVHILMGTVSVLF----PPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15405 234 MYL--KPSSVGSVNQGKVSSVFytnvVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 39-311 1.38e-28

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 111.41  E-value: 1.38e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15944  24 YLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTgpRVALIGTVLGMRSAAITAAPSLHLLTF--DYCHPGALSHAYCLHQDMIRLACSDT 196
Cdd:cd15944 104 LAAMAYDRYVAICNPLLYSTLMS--KRVCLQLMAGSYLAGLVNLVIHTTATFslSFCGSNIINHFFCDVPPLLALSCSDT 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 197 RFNR--LYGLCIIMLAmgSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSI----VHRFGQ 270
Cdd:cd15944 182 HINEilLYVFCGFVEM--SSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLrptsVYSLDQ 259

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22128751 271 HTSPLVHIlmgTVSVlfpPVMNPVIYSIKTQQIRRAIVKVI 311
Cdd:cd15944 260 DKWASVFY---TVVI---PMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 39-309 2.45e-28

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 110.59  E-value: 2.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15407  11 YLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGT---VLGMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15407  91 LASMAYDRHAAVCKPLHYTTTMTTKVCACLTIgcyVCGFLNASIHTGNTFRL---SFCKSNVINHFFCDIPPVLALSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTSPl 275
Cdd:cd15407 168 IHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDT- 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128751 276 vHILMGTVSVLFPPVMNPVIYSIKTQQIRRAIVK 309
Cdd:cd15407 247 -DKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 39-299 2.70e-28

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 110.22  E-value: 2.70e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15940  11 YLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTgpRVALIGTVLGMRSAAITAAPSLHLLTFD--YCHPGALSHAYCLHQDMIRLACSDT 196
Cdd:cd15940  91 LTIMAYDRYVAICNPLHYPTVMN--HKVCLWLVAALWLGGTVHSLAQTFLTIRlpYCGPNEIDSFFCDVPPVIKLACTDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 197 RFNRLygLCIIMLAMGSDVLFILL--SYAVILRTVLAIASAGeRLKALNTCVSHILAVLCFYVPVLglsivhrFGQHTSP 274
Cdd:cd15940 169 YLIDI--LIVSNSGLISLVCFVALlgSYIVILVSLRKRSTEG-RRKALSTCASHLTVVTLFFGPCI-------FIYTRPS 238

                       250       260
                ....*....|....*....|....*...
gi 22128751 275 LVHILMGTVSVLF---PPVMNPVIYSIK 299
Cdd:cd15940 239 TSFSEDKVVSVFYtvvTPLLNPIIYTLR 266
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 36-299 3.19e-28

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 109.99  E-value: 3.19e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15226   8 SLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLTgPRV----ALIGTVLGMRSAAITAAPSLHLLtfdYCHPGALSHAYCLHQDMIRL 191
Cdd:cd15226  88 MVLLIAMAFDRYVAICKPLHYLTIMS-PRMcillVVASWIIGFIHSLSQLAFVVNLP---FCGPNVVDSFFCDLPLVIKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 192 ACSDTrfnrlYGLCIIMLA---MGSDVLFILL--SYAVILRTVLAIASAGeRLKALNTCVSHILAVLCFYVPVLglsIVH 266
Cdd:cd15226 164 ACTDT-----YVLELMVVAnsgLISLVCFLLLliSYIVILVTVRKHSSGG-SSKALSTCSAHITVVVLFFGPCI---FIY 234

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128751 267 RFGQHTSPLVHILMGTVSVLFpPVMNPVIYSIK 299
Cdd:cd15226 235 VWPFSTFPVDKFLAVFYTVIT-PLLNPIIYTLR 266
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 39-299 6.96e-28

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 108.84  E-value: 6.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15939  11 YLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15939  91 LTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 nrlYGLCII----MLAMGSdVLFILLSYAVILRTVLAIASAGERlKALNTCVSHILAVLCFYVPVLGLSIvhrfgqhtSP 274
Cdd:cd15939 171 ---IGLLVVansgLICLLS-FLILLISYIVILYSLRTHSSEGRR-KALSTCGSHITVVVLFFVPCIFIYM--------RP 237

                       250       260
                ....*....|....*....|....*....
gi 22128751 275 LVHILMGTVSVLF----PPVMNPVIYSIK 299
Cdd:cd15939 238 VTTFPIDKVVAVFytiiTPMLNPLIYTLR 266
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 34-310 1.56e-27

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 108.33  E-value: 1.56e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  34 PIFMG-YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFS 112
Cdd:cd15418   6 VVFLLsYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 113 FMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLA 192
Cdd:cd15418  86 YSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 193 CSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRfGQHT 272
Cdd:cd15418 166 CDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS-SSHT 244

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128751 273 SPLVHILMGTVSVLFpPVMNPVIYSIKTQQIRRAIVKV 310
Cdd:cd15418 245 PDRDKVVALFYTVVN-PLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 36-299 2.12e-27

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 107.81  E-value: 2.12e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15936   8 LLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLTgPRVA---LIGTVLG--MRSAAITAApslhLLTFDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15936  88 VFLLSVMAYDRYIAIHKPLHYLTIMN-QGVCtglVAGSWLGgfAHSIVQVAL----LLQLPFCGPNVLDNFYCDVPQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERlKALNTCVSHILAVLCFYVPVLGLsivhrfgq 270
Cdd:cd15936 163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKR-KALSTCASQITVVTLIFVPCIYI-------- 233

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128751 271 HTSPLVHILMGT-VSVLF---PPVMNPVIYSIK 299
Cdd:cd15936 234 YARPFQTFPMDKaVSVLYtviTPMLNPMIYTLR 266
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 35-307 4.45e-27

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 107.18  E-value: 4.45e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFM 114
Cdd:cd15433   7 VLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 115 ESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15433  87 ECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFN--RLYGLCIIMLAMgsDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFY--VPVLGLSIVHRFGQ 270
Cdd:cd15433 167 DDETTevQMFVARVVILLL--PAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYgsAIYTYLQPIHRYSQ 244

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 271 HTSPLVHILMGTVSvlfpPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15433 245 AHGKFVSLFYTVMT----PALNPLIYTLRNKDVKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 39-299 2.81e-26

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 104.76  E-value: 2.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd15430  11 YLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRF 198
Cdd:cd15430  91 LAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHRFGQhtSPLVHI 278
Cdd:cd15430 171 NEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN--AQISDK 248

                       250       260
                ....*....|....*....|.
gi 22128751 279 LMGTVSVLFPPVMNPVIYSIK 299
Cdd:cd15430 249 LITLFYGVVTPMLNPIIYSLR 269
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 36-299 3.28e-26

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 104.67  E-value: 3.28e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15224   8 LIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLTgPRVALIGTVLGMRSAAITAAPSLHLL-TFDYCHPGALSHAYCLHQDMIRLACS 194
Cdd:cd15224  88 CVLLAVMAYDRYVAICHPLRYPVIMT-HQLCVQLAAGSWLSGFLISMIKVYFIsQLSFCGPNVINHFFCDISPLLNLSCT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRL--YGLCIIMLAMGSDVlfILLSYAVILRTVLAIASAGERLKALNTCVSHILAVLCFYVPVLGL----SIVHRF 268
Cdd:cd15224 167 DMSLAELvdFILALIILLVPLLV--TVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMyarpKAISSF 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128751 269 gqHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15224 245 --DSNKLVSVLYTVVT----PLLNPIIYCLR 269
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 31-299 6.76e-26

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 103.69  E-value: 6.76e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFVAIMGNATILHLVRTDPSLHQ-PMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVL---GMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQ 186
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACwagGFLHSATQAALVLRL---PFCGPNELDNFYCDVP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 187 DMIRLACSDTRFNRLygLCIIMLAMGSDVLFILL--SYAVILRTVLAIASAGeRLKALNTCVSHILAVLCFYVPVLGLSI 264
Cdd:cd15935 160 QVIKLACMDTYVVEV--LMVANSGLLSLVCFLVLlvSYGIILTTLRGRFREG-GGKALSTCSSHLTVVSLIFVPCIFVYL 236

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128751 265 VHRFGQHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15935 237 RPFSSSSVDKVASVFYTLIT----PALNPLIYTLR 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 36-299 4.10e-22

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 93.40  E-value: 4.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  36 FMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFME 115
Cdd:cd15938   8 LLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 116 SAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSD 195
Cdd:cd15938  88 MFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 196 TrfnrlyglCIIMLAMGSD------VLFILL--SYAVILRTvlaIASAGERLKALNTCVSHILAVLCFYVPVLGLSIVHR 267
Cdd:cd15938 168 T--------CVTELLMVSNsglistVCFVVLvtSYTTILVT---IRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPF 236

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128751 268 FGQHTSPLVHILMGTVSvlfpPVMNPVIYSIK 299
Cdd:cd15938 237 STFPVDKHVSVLYNVIT----PMLNPLIYTLR 264
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 35-299 4.91e-22

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 93.26  E-value: 4.91e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIM-GNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSF 113
Cdd:cd15937   6 LFLLFYLIILpGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 114 MESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVL---GMRSAAITAAPSLHLltfDYCHPGALSHAYCLHQDMIR 190
Cdd:cd15937  86 AEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASwagGFIHSIIQVALIIRL---PFCGPNVLDNFFCDITQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 191 LACSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERlKALNTCVSHILAVLCFYVPVLGLsIVHRFgq 270
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKS-KAASTCITHIIIVFVMFGPAIYI-YARPF-- 238

                       250       260
                ....*....|....*....|....*....
gi 22128751 271 HTSPLVHILMGTVSVLFpPVMNPVIYSIK 299
Cdd:cd15937 239 RSFPMDKVVAVFHTVIF-PLLNPMIYTLR 266
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 45-296 2.67e-17

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 80.03  E-value: 2.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751    45 GNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMV-GLVPCVLQQHFLHSFSFMESAVLFAMA 123
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPfGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   124 LDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPgalSHAYCLHQDMIRLACsdtrfNRLYG 203
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751   204 LCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERL-------KALNTCVSHILAVLCFYVPVLGLSIVH---RFGQHTS 273
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDslaLDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 22128751   274 PLVHILMGTVSV-LFPPVMNPVIY 296
Cdd:pfam00001 233 LLDKALSVTLWLaYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 40-299 6.65e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 79.25  E-value: 6.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQqHFLHSFSFMESAV- 118
Cdd:cd00637  10 VVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLL-GFLQSVSLLASILt 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGalshayclhqdMIRLACSDTRF 198
Cdd:cd00637  89 LTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYC-----------CCCLCWPDLTL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 199 NRLYGLCIIMLAMGSDVLFILLSYAVILRTVL--------------AIASAGERLKALNTCVSHILAVLCFYVPVLGLSI 264
Cdd:cd00637 158 SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLL 237

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128751 265 VHRFGQHTSPLVHIL--MGTVSVLFPPVMNPVIYSIK 299
Cdd:cd00637 238 LDVFGPDPSPLPRILyfLALLLAYLNSAINPIIYAFF 274
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 41-306 7.13e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 52.68  E-value: 7.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLhsFSFMESAV-L 119
Cdd:cd14972  11 FIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLV--LSLLASAYsL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 120 FAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIrlacsdtrfn 199
Cdd:cd14972  89 LAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGLPKSYL---------- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 200 rLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILAV----------LCfYVPVLGLSIVHRFG 269
Cdd:cd14972 159 -VLILVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAKtvvivlgvflVC-WLPLLILLVLDVLC 236

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128751 270 QHTSPLVHIL-MGTVSVLFPPVMNPVIYSIKTQQIRRA 306
Cdd:cd14972 237 PSVCDIQAVFyYFLVLALLNSAINPIIYAFRLKEMRRA 274
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 40-307 6.38e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.02  E-value: 6.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAVL 119
Cdd:cd15083  12 LIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 120 FAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL--------HLLT---FDYchpgalshayclhqdm 188
Cdd:cd15083  92 AAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgwsryvleGLLTscsFDY---------------- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 189 irlaCSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTV----LAIASAGERLKALN-------------TCVSHILA 251
Cdd:cd15083 156 ----LSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVrrheKAMKEMAKRFSKSElsspkarrqaevkTAKIALLL 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 252 VLCFYVPVLGLSIVHRFGQHTSP-LVHILMGTVSVLFPP---VMNPVIYSIKTQQIRRAI 307
Cdd:cd15083 232 VLLFCLAWTPYAVVALIGQFGYLeVLTPLATAIPAAFAKtsaIYNPVIYAFSHPKFRRAL 291
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 30-163 7.94e-07

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 49.48  E-value: 7.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDL--GLC---MSTLPSVLGVLWFdarmvGLVPCvlq 104
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLlvALLvmpFSAVYTLLGYWPF-----GPVLC--- 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22128751 105 qHFLHSFSFMESAV----LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAP 163
Cdd:cd14967  73 -RFWIALDVLCCTAsilnLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPP 134
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 34-306 2.20e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 48.23  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  34 PIFMG--YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSF 111
Cdd:cd14971   4 PLFFAliFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 112 SFMESAVLFAMALDRLIAIRFPLRYASVLTgPRVALIGTVLGMRSAAITAAPSLHLLTFDycHPGALSHAYCLHQDmirl 191
Cdd:cd14971  84 MHASIFTLVAMSLDRFLAVVYPLRSLHIRT-PRNALAASGCIWVVSLAVAAPVLALHRLR--NYTPGNRTVCSEAW---- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 192 acSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTV------LAIASAGERLKALNTCVSHILAVLCF--YVPVLGLS 263
Cdd:cd14971 157 --PSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLwrvavrPVLSEGSRRAKRKVTRLVLVVVVLFAacWGPIHAIL 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22128751 264 IVHRFGQHTSPLVHILMGTVSVLFP---PVMNPVIYSIKTQQIRRA 306
Cdd:cd14971 235 LLVALGPFPLTYATYALRIWAHCLAysnSAVNPVLYAFLSEHFRKA 280
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 41-165 4.05e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 47.62  E-value: 4.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGV-LWFDARMVGlvpCVLQQHFLHSFSFMESAVL 119
Cdd:cd15069  13 LSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITIsLGFCTDFHS---CLFLACFVLVLTQSSIFSL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22128751 120 FAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL 165
Cdd:cd15069  90 LAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFL 135
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 40-306 4.83e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 47.35  E-value: 4.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLglcmstLPSVLgVLWFDARMVGLVPCVLQQHFLH---SFSFMES 116
Cdd:cd15065  11 VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADL------LVALL-VMTFAVVNDLLGYWLFGETFCNiwiSFDVMCS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 117 AV----LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPsLHLltfdYCHPGALSHAYCLHQDMIRLA 192
Cdd:cd15065  84 TAsilnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLP-IHL----GWHRLSQDEIKGLNHASNPKP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 193 CSDTRFNRLYGL----------CIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSH-------------- 248
Cdd:cd15065 159 SCALDLNPTYAVvsslisfyipCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFQVPSLSSKHnnqgvsdhkaavtl 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22128751 249 --ILAV-LCFYVPVLGLSIVHRFGQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIRRA 306
Cdd:cd15065 239 giIMGVfLICWLPFFIINIIAAFCKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRA 299
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 41-165 8.31e-06

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 46.48  E-value: 8.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLglcmstlpsvlgvlwfdarMVGLV--PCVL-----QQHFLHSFSF 113
Cdd:cd14968  13 LSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADI-------------------LVGALaiPLAIlislgLPTNFHGCLF 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22128751 114 MESAV----------LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL 165
Cdd:cd14968  74 MACLVlvltqssifsLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMF 135
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 41-172 1.05e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 46.30  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMV-GLVPCVLQQHFLHSFSFMESAVL 119
Cdd:cd15005  13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTL 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22128751 120 FAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDY 172
Cdd:cd15005  93 FCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTF 145
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 29-136 1.10e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 46.15  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  29 HWISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP-SVLGVLWFDARMVGLVPCVLQQH- 106
Cdd:cd15052   1 NWAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTl 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 22128751 107 --FLHSFSFMEsavLFAMALDRLIAIRFPLRY 136
Cdd:cd15052  81 dvLFCTASIMH---LCTISLDRYMAIRYPLRT 109
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 41-304 1.22e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 46.08  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP-SVLGVLWFDARMVGlvpCVLQQHFLHSFSFMESAVL 119
Cdd:cd15068  13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPfAITISTGFCAACHG---CLFIACFVLVLTQSSIFSL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 120 FAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL----------HLLTFDYCHPGALShayCLHQDMI 189
Cdd:cd15068  90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLgwnncgqpkeGKNHSQGCGEGQVA---CLFEDVV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 190 RLACSdTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERL-----KALNTCVSHILAVLCFYVPVLGLSI 264
Cdd:cd15068 167 PMNYM-VYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERArstlqKEVHAAKSLAIIVGLFALCWLPLHI 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22128751 265 VHRF-----GQHTSPLVHILMGTVSVLFPPVMNPVIYSIKTQQIR 304
Cdd:cd15068 246 INCFtffcpDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 35-307 2.15e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 45.39  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYF--VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMV-GLVPCVLQQHFLHSF 111
Cdd:cd15337   5 IYIAIVgiLGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGFAGGIF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 112 SFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHL-----------LTFDYchpgalsh 180
Cdd:cd15337  85 GFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWgryvpegfqtsCTFDY-------- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 181 aycLHQDMIrlacsdtrfNRLYGLCIIMLAMGSDVLFILLSYAVILRTV-------LAIASAGER-------------LK 240
Cdd:cd15337 157 ---LSRDLN---------NRLFILGLFIFGFLCPLLIIIFCYVNIIRAVrnhekemTQTAKSGMGkdtekndarkkaeIR 224

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 241 ALNTCVSHILAVLCFYVPVLGLSIVHRFGQHTspLVHILMGTVSVLF---PPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15337 225 IAKVAIILISLFLLSWTPYAVVALLGQFGPAY--WITPYVSELPVMFakaSAIYNPIIYALSHPKFRAAL 292
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 39-167 4.35e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 44.29  E-value: 4.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPC----VLQQHFLHSFSFM 114
Cdd:cd14986  11 FVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCrivkYLQVVGLFASTYI 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22128751 115 esavLFAMALDRLIAIRFPLryaSVLTGPRVALIGTVLGMRSAAITAAPSLHL 167
Cdd:cd14986  91 ----LVSMSLDRYQAIVKPM---SSLKPRKRARLMIVVAWVLSFLFSIPQLVI 136
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 41-162 5.10e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.01  E-value: 5.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQ-----------HFLH 109
Cdd:cd15351  13 VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHmdnvidtmicsSVVS 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22128751 110 SFSFmesavLFAMALDRLIAIRFPLRYASVLTGPRValIGTVLGMRSAAITAA 162
Cdd:cd15351  93 SLSF-----LGAIAVDRYITIFYALRYHSIMTLQRA--VNAIAGIWLASTVSS 138
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
 40-143 6.28e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 43.74  E-value: 6.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751    40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVlgVLWFDARMVGLVPCVLQQHFLHSFSFMESAVL 119
Cdd:pfam10320   2 VIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFV--VLLFTGTQLTRNECFWMISFYIFGQTAQGPLM 79

                          90       100
                  ....*....|....*....|....
gi 22128751   120 FAMALDRLIAIRFPLRYASVLTGP 143
Cdd:pfam10320  80 LMIGIDRLIAVKFPIFYRLLSSSK 103
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 40-136 1.01e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 42.99  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCmstLPSVLGVLWFDARMV---GLVPCVLQQhFLHSFS-FME 115
Cdd:cd15196  12 VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVA---LFNVLPQLIWDITYRfygGDLLCRLVK-YLQVVGmYAS 87

                        90       100
                ....*....|....*....|.
gi 22128751 116 SAVLFAMALDRLIAIRFPLRY 136
Cdd:cd15196  88 SYVLVATAIDRYIAICHPLSS 108
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 62-306 1.14e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 43.13  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  62 PMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAVLFAMALDRLIAIRFPLRYASVLT 141
Cdd:cd15104  34 KSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 142 GPRVALIGTVLGMRSAAITAAPSLHLLTFDYCHPGALSHAYCLHQDMIRLACSDTRFNrlygLCIIMLAMGSDVLFILLS 221
Cdd:cd15104 114 GKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRVLLVLSCMVFFP----ALLLFVFCYCDILKIARV 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 222 YAVILRTV-LAIASAGER------LKALNTCVSHILAVLCFYVPVLGLSIVHRFGQ--HTSPLVHILMGTVSvLFPPVMN 292
Cdd:cd15104 190 HSRAIYKVeHALARQIHPrrtlsdFKAARTVAVLIGCFLLSWLPFQITGLVQALCDecKLYDVLEDYLWLLG-LCNSLLN 268

                       250
                ....*....|....
gi 22128751 293 PVIYSIKTQQIRRA 306
Cdd:cd15104 269 PWIYAFWQKEVRRA 282
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 31-148 1.70e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 42.42  E-value: 1.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGY--FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15050   1 APLGIALSTisLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALI 148
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLM 120
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 31-159 2.06e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 2.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMgyFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDAR-MVGLVPCvlqqHFLH 109
Cdd:cd15053   5 LFLLLLP--LLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILC----DIYI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128751 110 SFSFMESAV----LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAI 159
Cdd:cd15053  79 AMDVMCSTAsifnLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAI 132
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 62-167 2.06e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 42.23  E-value: 2.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  62 PMYYFLAILAVTDLGLCMSTLPSVLGVlwFDARMVGLVPCVLQQH--FLHSFSFMESA-VLFAMALDRLIAIRFPLRYAS 138
Cdd:cd14981  36 VFYRLVAGLAITDLLGILLTSPVVLAV--YASNFEWDGGQPLCDYfgFMMSFFGLSSLlIVCAMAVERFLAITHPFFYNS 113

                        90       100
                ....*....|....*....|....*....
gi 22128751 139 VLTGPRVALIGTVLGMRSAAITAAPSLHL 167
Cdd:cd14981 114 HVKKRRARLMLGAVWAFALLIASLPLLGL 142
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 40-163 2.28e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 42.32  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCvlqqHFLHSFSFMESAV- 118
Cdd:cd15051  12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFC----NIYISLDVMLCTAs 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22128751 119 ---LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAP 163
Cdd:cd15051  88 ilnLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLP 135
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 39-168 2.47e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 42.09  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLgLCMSTLPSVLGVLW-FDARMVGLVPCVLQQHFLHSFSFMESA 117
Cdd:cd15928  11 MLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWrYRPWRFGDLLCRLMYFFSETCTYASIL 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22128751 118 VLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMrSAAITAAPSLHLL 168
Cdd:cd15928  90 HITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWA-VAIVSAGPALVLV 139
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 31-165 3.95e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 41.42  E-value: 3.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFV--AIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPsvlgvlwFDARMVGLVPCVLQQHFL 108
Cdd:cd15326   1 ILLGLVLGAFIlfAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-------FSATLEILGYWVFGRIFC 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22128751 109 HSFSFMESAV-------LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL 165
Cdd:cd15326  74 DIWAAVDVLCctasilsLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLL 137
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 30-145 4.63e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 41.30  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGyFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPsvLGVLWFDARMVGLVPCVLQQHFLH 109
Cdd:cd15070   3 YISIEILIG-LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLV 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 22128751 110 SFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRV 145
Cdd:cd15070  80 VFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRI 115
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 40-307 6.96e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 40.66  E-value: 6.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDL---GLCMstlPSVLGVLWFDARMVGLVPCVLqqhflhsFSFMES 116
Cdd:cd14993  12 LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLlvsLFCM---PLTLLENVYRPWVFGEVLCKA-------VPYLQG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 117 AV-------LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMrSAAITAAPSL---HLLTFDYCHPGALSHAYClhQ 186
Cdd:cd14993  82 VSvsasvltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV-IAIIIMLPLLvvyELEEIISSEPGTITIYIC--T 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 187 DMIrlacSDTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGERLKALNTCVSHILA------------VLC 254
Cdd:cd14993 159 EDW----PSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILRskkkvarmlivvVVL 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22128751 255 F---YVPVLGLSIVHRFGqhtSPLVHILMGTVSVLFPPV---------MNPVIYSIKTQQIRRAI 307
Cdd:cd14993 235 FalsWLPYYVLSILLDFG---PLSSEESDENFLLILPFAqllgysnsaINPIIYCFMSKKFRRGF 296
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 41-237 7.34e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 40.57  E-value: 7.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESAVLF 120
Cdd:cd15202  13 FSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLT 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 121 AMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSLHLLTFDY--------CHPGALSHAyclhqdmirla 192
Cdd:cd15202  93 AIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYsedivrslCLEDWPERA----------- 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 22128751 193 csdTRFNRLYGLCIIMLAMGSDVLFILLSYAVILRTVLAIASAGE 237
Cdd:cd15202 162 ---DLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGD 203
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 31-165 9.28e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 40.16  E-value: 9.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFV--AIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP-----SVLGVLWFDARMVGLVPCVl 103
Cdd:cd15062   1 IVVGVALGAFIlfAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPfsatlEVLGYWAFGRIFCDVWAAV- 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22128751 104 qQHFLHSFSFMEsavLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL 165
Cdd:cd15062  80 -DVLCCTASIMS---LCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLL 137
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 40-307 1.20e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 39.95  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLqQHFLHSFSFMESAV- 118
Cdd:cd15001  11 VLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLQLLSFICSVLt 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 119 LFAMALDRLIAIRFPL--RYASVLTGPRVALIGTVLgmrSAAITAAPSLHL--LTFDYCHPGALSHAYClhqdmirLACS 194
Cdd:cd15001  90 LTAISIERYYVILHPMkaKSFCTIGRARKVALLIWI---LSAILASPVLFGqgLVRYESENGVTVYHCQ-------KAWP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751 195 DTRFNRLY----GLCIIMLAmgsdvlFILLSYAVILRTvlaiasageRLKALNTCVSHILAVLCFYVPVLGLSIVHRFG- 269
Cdd:cd15001 160 STLYSRLYvvylAIVIFFIP------LIVMTFAYARDT---------RKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDv 224

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22128751 270 ---QHTSPLVHILMG-TVSVLFPPVMNPVIYSIKTQQIRRAI 307
Cdd:cd15001 225 istLHTQALKYMRIAfHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 40-148 1.24e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 39.92  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  40 FVAIMGNATILhLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLG-VLWFDARMVGLVPCVLQQHFLHSFSFMESAV 118
Cdd:cd14978  12 IFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYPLANTFQTA 90

                        90       100       110
                ....*....|....*....|....*....|....
gi 22128751 119 ----LFAMALDRLIAIRFPLRYASVLTGPRVALI 148
Cdd:cd14978  91 svwlTVALTVERYIAVCHPLKARTWCTPRRARRV 124
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 35-160 1.56e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 39.65  E-value: 1.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDL--GLC---MSTLPSVLGVLWFDARMVglvpCVLqqhfLH 109
Cdd:cd15067   6 LSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLlvGSIvmpFSILHEMTGGYWLFGRDW----CDV----WH 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128751 110 SFSFMESAV----LFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAIT 160
Cdd:cd15067  78 SFDVLASTAsilnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS 132
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
 39-176 1.76e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 39.42  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  39 YFVAIMGNATILH-LVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFLHSFSFMESA 117
Cdd:cd15097  11 FLLGTVGNSLVLAvLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSF 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22128751 118 VLFAMALDRLIAIRFPLRYASVLTgPRVALIGTVLGMRSAAITAAPSL-HLLTFDY-----CHPG 176
Cdd:cd15097  91 TLAAVSVDRYLAIRYPLRSRELRT-PRNAVAAIALIWGLSLLFAGPYLsYYDLIDYanstvCMPG 154
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 35-148 3.48e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 38.49  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  35 IFMGYFVA-IMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP-SVLGVLWFDARMVGLVPCVLQQHFLHSFS 112
Cdd:cd14979   6 IYVAIFVVgIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPvELYNFWWQYPWAFGDGGCKLYYFLFEACT 85

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 22128751 113 FMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALI 148
Cdd:cd14979  86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRF 121
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 31-163 4.25e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 38.34  E-value: 4.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFV--AIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHFL 108
Cdd:cd15325   1 IVLGVILGGFIlfGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128751 109 HSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAP 163
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGP 135
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 41-148 5.18e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 5.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  41 VAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVglvpcVLQQHFL-HSFSFMESAV- 118
Cdd:cd15354  13 ISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL-----VIEDAFVrHIDNVFDSLIc 87

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22128751 119 ---------LFAMALDRLIAIRFPLRYASVLTGPRVALI 148
Cdd:cd15354  88 isvvasmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGII 126
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 30-163 9.03e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 37.43  E-value: 9.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  30 WISLPIFMGYFVAIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLPSVLGVLWFDARMVGLVPCVLQQHfLH 109
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTS-VD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128751 110 SFSFMES-AVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAP 163
Cdd:cd15058  81 VLCVTASiETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVP 135
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 31-165 9.62e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.20  E-value: 9.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128751  31 ISLPIFMGYFV--AIMGNATILHLVRTDPSLHQPMYYFLAILAVTDLGLCMSTLP--SVLGVLWFDArmVGLVPCVLQQH 106
Cdd:cd15327   1 VGVGVFLAIFIlmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfsATLEVLGFWA--FGRVFCDIWAA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22128751 107 FLHSFSFMESAVLFAMALDRLIAIRFPLRYASVLTGPRVALIGTVLGMRSAAITAAPSL 165
Cdd:cd15327  79 VDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLL 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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