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Conserved domains on  [gi|112983541|ref|NP_667302|]
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olfactory receptor 568 [Mus musculus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 28-298 1.14e-163

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 456.19  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLH 104
Cdd:cd15222    2 WISIPFCLLYLvalLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVI 184
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 185 QLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYG 264
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 112983541 265 HSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 28-298 1.14e-163

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 456.19  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLH 104
Cdd:cd15222    2 WISIPFCLLYLvalLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVI 184
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 185 QLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYG 264
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 112983541 265 HSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 33-306 4.93e-101

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 297.88  E-value: 4.93e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541   33 FCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:pfam13853   1 FCLMYLiifLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPA 269
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 112983541  270 FVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 28-298 1.14e-163

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 456.19  E-value: 1.14e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLH 104
Cdd:cd15222    2 WISIPFCLLYLvalLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVI 184
Cdd:cd15222   82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 185 QLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYG 264
Cdd:cd15222  162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 112983541 265 HSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15222  242 KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 27-298 2.01e-121

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 349.28  E-value: 2.01e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15917    1 IWLSIPFCAMYlvaLLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15917   81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15917  161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15917  241 GHHVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 27-298 2.90e-114

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 331.15  E-value: 2.90e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15953    1 IWISIPFCLMYivtLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15953   81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15953  161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15953  241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 27-298 9.38e-113

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 327.32  E-value: 9.38e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15221    1 VWISIPFCSMYivaLLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15221   81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15221  161 ARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15221  241 GRHIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 27-298 3.98e-112

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 325.84  E-value: 3.98e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15951    1 VWISIPFCIMYavaLLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15951  161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15951  241 GHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 27-298 2.47e-107

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 313.55  E-value: 2.47e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15952    1 FWIGFPFCAVYLIallGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15952   81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALfSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15952  161 AKLACASIRINIIYGLFAI-SVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRF 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15952  240 GHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 33-306 4.93e-101

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 297.88  E-value: 4.93e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541   33 FCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:pfam13853   1 FCLMYLiifLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPA 269
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 112983541  270 FVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 27-298 1.62e-100

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 296.25  E-value: 1.62e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15950    1 FWIAIPFCSMYviaLLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15950  241 GQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 13-299 1.80e-99

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 294.38  E-value: 1.80e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  13 TFLLTGIPGLRAAQVWISIPFCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAR 89
Cdd:cd15949    3 TFILLGIPGLEPLHVWISIPFCSMYLIavlGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  90 EINLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCS 169
Cdd:cd15949   83 EIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 170 SLVLSHSYCYHVDVIQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAI 249
Cdd:cd15949  163 TNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILA 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 112983541 250 FYIPLISLSLVHRYGHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIR 299
Cdd:cd15949  243 FYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 26-299 2.33e-98

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 291.04  E-value: 2.33e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  26 QVWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFF 102
Cdd:cd15948    1 HPWISIPFCSAFtvaLLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 103 LHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVD 182
Cdd:cd15948   81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 183 VIQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHR 262
Cdd:cd15948  161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 112983541 263 YGHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIR 299
Cdd:cd15948  241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 28-302 3.00e-94

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 280.33  E-value: 3.00e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLH 104
Cdd:cd15223    2 WLSLPFLLLYlvaLVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVI 184
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 185 QLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYG 264
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 112983541 265 HSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15223  242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 27-298 1.42e-89

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 268.56  E-value: 1.42e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15955    1 HWIGIPFCIMFLlavLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVK-RLSFCSSLVLSHSYCYHVD 182
Cdd:cd15955   81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 183 VIQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHR 262
Cdd:cd15955  161 VVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 112983541 263 YGHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15955  241 FGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 27-298 2.04e-89

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 268.23  E-value: 2.04e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15954    1 IWISIPFCFMYIiamVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15954   81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15954  161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 112983541 264 -GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15954  241 gGHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 27-298 1.55e-86

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 260.95  E-value: 1.55e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15956    1 VWLSLPFCFIYvlsLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15956   81 HAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd15956  161 VKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 264 GHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQI 298
Cdd:cd15956  241 GHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 27-294 7.05e-72

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 223.13  E-value: 7.05e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd13954    1 ILLFVLFLLIYLltlLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 264 GHSAPafVHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd13954  241 SYSSD--LDKVVSVFYTVVTPMLNPIIYSLR 269
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 33-302 2.40e-56

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 183.43  E-value: 2.40e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15225    7 FLLIYlvtLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15225   87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPa 269
Cdd:cd15225  167 DTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPE- 245

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112983541 270 fVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15225  246 -TDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 35-302 1.11e-54

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 179.31  E-value: 1.11e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15234   12 LVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15234   92 AVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLIN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFY----IPLISLSLVHRYGHSAPAf 270
Cdd:cd15234  172 NILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYgtglGVYISSAVTHSSRKTAVA- 250

                        250       260       270
                 ....*....|....*....|....*....|..
gi 112983541 271 vhTVMANVfllIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15234  251 --SVMYTV---VTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 35-292 4.01e-53

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 175.11  E-value: 4.01e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15918   12 LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15918   92 AVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLgLFALFSTTGFDCP-CILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPAfvHT 273
Cdd:cd15918  172 ELV-ILVLGGLVGLVPFlCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASK--DS 248

                        250
                 ....*....|....*....
gi 112983541 274 VMANVFLLIPPVLNPIIYS 292
Cdd:cd15918  249 VAAVMYTVVTPMLNPFIYS 267
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 35-302 6.07e-53

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 174.72  E-value: 6.07e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15235   13 LLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNAR-IAQIGTIVLIRNVAVMLPVVLfVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRI 193
Cdd:cd15235   93 AVMAYDRYVAICHPLHYATVMSPKRcLLLVAGSWLLSHLHSLLHTLL-MSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 194 NSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGHSAPAFVHT 273
Cdd:cd15235  172 NELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYF--QPSSSYSADKDR 249

                        250       260
                 ....*....|....*....|....*....
gi 112983541 274 VMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15235  250 VATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 33-294 4.81e-51

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 169.61  E-value: 4.81e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15230    7 FLLIYlitLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15230   87 ECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLgLFALFSTTGFDCPC-ILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAP 268
Cdd:cd15230  167 DTHINELV-LFAFSGFIGLSTLLiILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLD 245

                        250       260
                 ....*....|....*....|....*..
gi 112983541 269 afvHTVMANVF-LLIPPVLNPIIYSVK 294
Cdd:cd15230  246 ---QDKVVSVFyTVVIPMLNPLIYSLR 269
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 27-294 2.82e-50

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 167.55  E-value: 2.82e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15914    1 LLLFILLLLIYLfiiTGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINsVLGLFALFSTTGF-DCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhR 262
Cdd:cd15914  161 LSLACTDTSLN-VLVDFVIHAVIILlTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYL--R 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 112983541 263 YGHSAPAFVHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15914  238 LSKSYSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 35-302 3.17e-49

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 165.13  E-value: 3.17e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15231   12 LVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15231   92 AVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPafVHTV 274
Cdd:cd15231  172 EVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLD--KDTL 249

                        250       260
                 ....*....|....*....|....*...
gi 112983541 275 MANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15231  250 ISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 14-306 4.44e-49

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 165.14  E-value: 4.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  14 FLLTGIPGLRAAQVWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEARE 90
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYgitLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  91 INLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSS 170
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 171 LVLSHSYCYHVDVIQLSCTDNRINSVLgLFALFS-TTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAI 249
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELL-LFIFGSlNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 112983541 250 FYIPLISLSLVHRYGHSapafVHTV-MANVFL-LIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:cd15410  240 FHGTILFMYCRPSSSYS----LDTDkVASVFYtVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 35-304 1.38e-48

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 163.72  E-value: 1.38e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15412   12 LITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYML 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15412   92 AVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVK 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SvlglFALFSTTGFDCPC----ILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPaf 270
Cdd:cd15412  172 E----TAMFIVAGFNLSSslliILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVE-- 245

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 271 vHTVMANVF-LLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15412  246 -QSKIVAVFyTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 35-304 3.43e-48

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 162.43  E-value: 3.43e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGN-SMILLVIVREQsLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV 113
Cdd:cd15417   12 LVTLLWNlGLIILIRMDSH-LHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 114 LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRI 193
Cdd:cd15417   91 LAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 194 NSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPafVHT 273
Cdd:cd15417  171 SQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQD--QDK 248

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 274 VMANVFLLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15417  249 VASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 35-302 7.41e-48

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 161.61  E-value: 7.41e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15229   12 LLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15229   92 SAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFAN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLgLFALFSTTGFDC-PCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGHSAPAFVHT 273
Cdd:cd15229  172 KMV-LLTSSVIFGLGSfLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYL--RPNSASSSVLDR 248

                        250       260
                 ....*....|....*....|....*....
gi 112983541 274 VMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15229  249 VFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 33-292 9.19e-48

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 161.27  E-value: 9.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15232    7 FLFLYaaaLTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15232   87 ELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLIslslvhrYGHSAPA 269
Cdd:cd15232  167 DTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVI-------YTYIRPS 239

                        250       260
                 ....*....|....*....|....*...
gi 112983541 270 FVHT-----VMANVFLLIPPVLNPIIYS 292
Cdd:cd15232  240 SSYSpekdkVVAVLYSVVTPTLNPLIYS 267
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 33-301 1.79e-47

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 160.57  E-value: 1.79e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15420    7 FSLLYiftLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15420   87 ECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHsaPA 269
Cdd:cd15420  167 DTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN--SA 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 112983541 270 FVHTVMANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15420  245 EQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 14-306 3.10e-47

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 160.61  E-value: 3.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  14 FLLTGIPGLRAAQVWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEARE 90
Cdd:cd15943    2 FILLGLTDNPELQVILFAVFLVIYlitLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  91 INLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSS 170
Cdd:cd15943   82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 171 LVLSHSYCYHVDVIQLSCTDNRINSVLgLFALFSTTG-FDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAI 249
Cdd:cd15943  162 NVINHFFCDVPPLLKLSCSDTHVNEIV-LFAFAIFLGiFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112983541 250 FYIPLISLSLvhRYGHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:cd15943  241 FYGTTLFMYL--RPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 14-299 8.54e-47

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 159.02  E-value: 8.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  14 FLLTGIPGLRAAQVWISIPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEARE 90
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYvitLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  91 INLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQI---GTIVLIRNVAVMLPVVLfvkRLSF 167
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLvagSYLAGFLNSTVHTGFIL---RLSF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 168 CSSLVLSHSYCYHVDVIQLSCTDNRINSVLglfaLFSTTGFD----CPCILLSYVLIIRSVLSIASSDERQKAFNTCISH 243
Cdd:cd15408  158 CGSNVINHFFCDGPPLLALSCSDTSLNEML----LFAFVGFNvlttTLVILISYTYILATILRMRSAEGRHKAFSTCASH 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112983541 244 ISAVAIFYIPLISLSLVHRYGHSAPafvHTVMANVFL-LIPPVLNPIIYSVKTKQIR 299
Cdd:cd15408  234 LTAVTLFYGSLAFMYLRPSSRYSLD---LDKVASVFYtVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 31-304 9.57e-47

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 158.74  E-value: 9.57e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFT 107
Cdd:cd15407    5 IIFTLIYlitLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 108 FMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLS 187
Cdd:cd15407   85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 188 CTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSA 267
Cdd:cd15407  165 CSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSM 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 112983541 268 PAfvhTVMANVFL-LIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15407  245 DT---DKMASVFYtMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 33-292 2.85e-46

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 157.26  E-value: 2.85e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15911    7 FLVIYIvtmAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAAT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15911   87 ECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapA 269
Cdd:cd15911  167 DTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS--R 244

                        250       260
                 ....*....|....*....|...
gi 112983541 270 FVHTVMANVFLLIPPVLNPIIYS 292
Cdd:cd15911  245 DLNKVFSLFYTVLTPLVNPLIYS 267
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 35-304 2.86e-46

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 157.48  E-value: 2.86e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGN-SMILLVIVREQsLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV 113
Cdd:cd15413   12 LTTVMGNlGMIILTRLDSR-LQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 114 LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRI 193
Cdd:cd15413   91 LSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 194 NSVLGL-FALFSTTgFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapaFVH 272
Cdd:cd15413  171 KELIILiFAGFNLI-SSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHS---LDT 246

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112983541 273 TVMANVF-LLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15413  247 DKMASVFyTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 35-292 2.96e-45

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 154.56  E-value: 2.96e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15912   12 LLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR-- 192
Cdd:cd15912   92 AVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRli 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 --INSVLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHS---- 266
Cdd:cd15912  172 elLDFILASVVLLGSLLL----TIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSldln 247

                        250       260
                 ....*....|....*....|....*..
gi 112983541 267 -APAFVHTVMAnvfllipPVLNPIIYS 292
Cdd:cd15912  248 kVVALLNTVVT-------PLLNPFIYT 267
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 35-304 4.00e-45

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 154.49  E-value: 4.00e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15409   12 LITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15409   92 AAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSIN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPafvHTV 274
Cdd:cd15409  172 ELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALD---QDM 248

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 275 MANVFL-LIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15409  249 MDSLFYtIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 35-304 2.63e-44

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 152.47  E-value: 2.63e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15411   12 VITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15411   92 GLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLIslsLVHRYGHSAPAFVHTV 274
Cdd:cd15411  172 EMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGI---FTYLRPSSSYSLGQDK 248

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 275 MANVFL-LIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15411  249 VASVFYtVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 31-306 6.68e-44

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 151.75  E-value: 6.68e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLS-------GN-SMILLVIVREQsLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFF 102
Cdd:cd15406   10 LPLFLLFLGiyvvtvvGNlGMILLITLSSQ-LHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 103 LHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVD 182
Cdd:cd15406   89 FCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 183 VIQLSCTDNRINSVLGL----FALFSTTGfdcpCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLS 258
Cdd:cd15406  169 LLKLSCSSTYINELLLFivggFNVLATTL----AILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMY 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 112983541 259 LvhryghsAPAFVHTV----MANVFL-LIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:cd15406  245 L-------KPSSSSSMtqekVSSVFYtTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 33-292 8.69e-44

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 150.68  E-value: 8.69e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLslslCTLSTTLGVLWFEA----REINLNACIAQMFFLHG 105
Cdd:cd15227    7 FLLIYLaalTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDL----CYISVTVPKSIANSltntRSISFLGCVAQVFLFIF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 106 FTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNV--AVMLPVVLFvkRLSFCSSLVLSHSYCyhvDV 183
Cdd:cd15227   83 FAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLlyGALHTANTF--SLPFCGSNVIHQFFC---DI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQL---SCTDNRINSVlGLFALFSTTGFDC-PCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYiplISLSL 259
Cdd:cd15227  158 PQLlklSCSDTYLNEI-GVLVLSVCLGLGCfVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFL---STGSF 233

                        250       260       270
                 ....*....|....*....|....*....|....
gi 112983541 260 VHRYGHSAPAFVHTVMANVFL-LIPPVLNPIIYS 292
Cdd:cd15227  234 AYLKPPSDSPSLLDLLLSVFYsVVPPTLNPIIYS 267
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 14-304 1.14e-43

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 151.05  E-value: 1.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  14 FLLTGIPGLRAAQVWISIPFCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEARE 90
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLtlvGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  91 INLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSS 170
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 171 LVLSHSYCYHVDVIQLSCTDNRINSVLgLFALFSTTGFDCPC-ILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAI 249
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELL-LFALCGFIQTSTFLaIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 112983541 250 FYIPLISLSLvhrYGHSAPAFVHTVMANVF-LLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15945  240 FYGTLLFMYL---RPSSSYSLDTDKMTSVFyTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 35-301 1.22e-43

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 150.63  E-value: 1.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15429   12 LLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15429   92 AVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapAFVHTV 274
Cdd:cd15429  172 EVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS--ALQEKM 249

                        250       260
                 ....*....|....*....|....*..
gi 112983541 275 MANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15429  250 ISLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 33-294 3.40e-43

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 149.38  E-value: 3.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15915   10 LYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15915   90 LLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 INSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDE-RQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPAfv 271
Cdd:cd15915  170 LNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVRSKEgRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQ-- 247

                        250       260
                 ....*....|....*....|...
gi 112983541 272 HTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15915  248 DRIVALLYTVVTPVLNPLIYTLR 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 28-292 3.64e-43

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 149.30  E-value: 3.64e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFT 107
Cdd:cd15431    5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 108 FMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIgtIVLIRNVAVMLPVV-LFVKRLSFCSSLVLSHSYCYHVDVIQL 186
Cdd:cd15431   85 ITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQL--AAGSWVSAFLLTVIpVLTMPLHFCGPNVINHFFCEVQALLKL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 187 SCTDNRINSVL----GLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHR 262
Cdd:cd15431  163 ACSDTSLNEILmfatSIFTLLLPFSF----ILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQ 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 263 YGHSAPAfvhTVMANVFL-LIPPVLNPIIYS 292
Cdd:cd15431  239 SKSSSDQ---DKIISVFYgVVTPMLNPLIYS 266
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 33-304 1.36e-42

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 147.84  E-value: 1.36e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15419    7 FLVIYmvtVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15419   87 EGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLglfaLFSTTGF----DCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLIslslvhrYGH 265
Cdd:cd15419  167 DTFINELV----MFVLCGLiivsTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVF-------FMY 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 112983541 266 SAPAFVHT-----VMANVFLLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15419  236 AQPGAVSSpeqskVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 33-292 3.47e-42

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 146.65  E-value: 3.47e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15237   10 IYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15237   90 LLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTS 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 INS----VLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAP 268
Cdd:cd15237  170 LNEavifVTSVLVLLIPFSL----ILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPD 245

                        250       260
                 ....*....|....*....|....*
gi 112983541 269 afvHTVMANVFL-LIPPVLNPIIYS 292
Cdd:cd15237  246 ---QDKMISVFYtIVTPMLNPLIYS 267
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 35-302 1.40e-41

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 145.26  E-value: 1.40e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15424   12 LLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15424   92 GAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHIT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGhSAPAFvHTV 274
Cdd:cd15424  172 EAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG-STPDR-DKQ 249

                        250       260
                 ....*....|....*....|....*...
gi 112983541 275 MANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15424  250 IAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 33-309 1.54e-41

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 145.26  E-value: 1.54e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15414   10 VYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQ--IGTIVLIRNVAVMLPVVLFvkRLSFCSSLVLSHSYCYHVDVIQLSCTD 190
Cdd:cd15414   90 LLASMAYDRYVAICNPLLYTVIMSQRVCVQlvVGPYVVGLLNTTTHTTAAF--FLPFCGPNVINHFFCDIPPLLSLSCAD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 191 NRINSVLgLFALFSTTGFDCPC-ILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGHSAPA 269
Cdd:cd15414  168 TQINKWV-LFIMAGALGVLSGLiILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYV--RPSSSSSL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 112983541 270 FVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAILKVLNQK 309
Cdd:cd15414  245 DLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 38-304 2.35e-41

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 144.82  E-value: 2.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAM 117
Cdd:cd15416   15 LLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAM 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 118 AFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRINSVL 197
Cdd:cd15416   95 AYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKIL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 198 GLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPAfvHTVMAN 277
Cdd:cd15416  175 PSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQ--NKVVSV 252

                        250       260
                 ....*....|....*....|....*..
gi 112983541 278 VFLLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15416  253 FYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 31-302 4.74e-41

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 143.73  E-value: 4.74e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFME 110
Cdd:cd15228    8 LAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 111 SGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNV--AVMLPVVLFvkRLSFCSSLVLSHSYCYHVDVIQLSC 188
Cdd:cd15228   88 CLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSfhATILTSLTF--TLPYCGSNVVDYFFCDIFPVLKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 189 TDNRINSVLGlfalFSTTGF-DCPC---ILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLslvhrYG 264
Cdd:cd15228  166 ADTSIAETVS----FTNVGLvPLTCfllILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALI-----YT 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 112983541 265 HSAPAFVHTVMANVFL-LIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15228  237 QPTPSPVLVTPVQIFNnVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 33-302 6.17e-41

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 6.17e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15236    7 FLAMYLTtvlGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15236   87 DSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPA 269
Cdd:cd15236  167 STSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDK 246

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112983541 270 fvHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15236  247 --DIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 33-294 1.23e-40

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 142.35  E-value: 1.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLY---LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15939    7 FLLIYlatVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15939   87 EIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRinsVLGLFALfSTTGFDCP----CILLSYVLIIRSvLSIASSDERQKAFNTCISHISAVAIFYIPLISLslvhrYGH 265
Cdd:cd15939  167 DTY---VIGLLVV-ANSGLICLlsflILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFI-----YMR 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 112983541 266 SAPAF-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15939  237 PVTTFpIDKVVAVFYTIITPMLNPLIYTLR 266
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 35-304 4.43e-40

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 141.40  E-value: 4.43e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15415   12 FITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15415   92 AVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHIN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVL-----GLFALFSTTgfdcpCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLIslslvhrYGHSAPA 269
Cdd:cd15415  172 ELLlltfsGVIAMSTLL-----TIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVS-------FSYIQPS 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 112983541 270 FVHT-----VMANVFLLIPPVLNPIIYSVKTKQIRKAILK 304
Cdd:cd15415  240 SQYSleqekVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 35-302 7.33e-40

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 140.66  E-value: 7.33e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTL-GVLWFEAREINLNACIAQMFFLHGFTFMESGV 113
Cdd:cd15916   12 LLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFFHFLGSTECFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 114 LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRI 193
Cdd:cd15916   92 YTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 194 NSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRyghsAPAFVHT 273
Cdd:cd15916  172 NELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG----SKEALDG 247

                        250       260
                 ....*....|....*....|....*....
gi 112983541 274 VMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15916  248 VIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 35-291 8.47e-40

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 140.50  E-value: 8.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15224   12 VLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15224   92 AVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLIslslvhrYGHSAPAFVHTV 274
Cdd:cd15224  172 ELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATL-------FMYARPKAISSF 244

                        250       260
                 ....*....|....*....|..
gi 112983541 275 MAN-----VFLLIPPVLNPIIY 291
Cdd:cd15224  245 DSNklvsvLYTVVTPLLNPIIY 266
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 33-294 1.12e-39

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 140.07  E-value: 1.12e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15947   10 FYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15947   90 LLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 IN----SVLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLV--HRYGHS 266
Cdd:cd15947  170 FNelelFVASVFFLLVPLSL----ILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQppSSYSQD 245

                        250       260
                 ....*....|....*....|....*...
gi 112983541 267 APAFVhtvmANVFLLIPPVLNPIIYSVK 294
Cdd:cd15947  246 QGKFI----SLFYTVVTPTLNPLIYTLR 269
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 33-302 2.50e-39

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 139.44  E-value: 2.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15434   10 FYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNA---RIAQIGTIVLIRNVAVMLPVVLfvkRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15434   90 LLAVMAYDRYAAVCQPLHYTVVMHPRlcwKLVAMSWLIGFGNSLVLSPLTL---SLPRCGHHRVDHFFCEMPALIKLACV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINS----VLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGH 265
Cdd:cd15434  167 DTTAYEatifALGVFILLFPLSL----ILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYL--QPKN 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 112983541 266 SAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15434  241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 40-302 4.68e-39

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 138.77  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAMAF 119
Cdd:cd15233   17 GNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 120 DRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRINSVLGL 199
Cdd:cd15233   97 DRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 200 FALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIplISLSLVHRYGHSAPAFVHTVMANVF 279
Cdd:cd15233  177 VFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYG--TGVFSYMRLGSVYSSDKDKVIGILN 254

                        250       260
                 ....*....|....*....|...
gi 112983541 280 LLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15233  255 TVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 33-302 6.46e-39

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 138.38  E-value: 6.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15432   10 FYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15432   90 LLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 INSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhrYGHSAPAFVH 272
Cdd:cd15432  170 ANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYL---QPPSNSSHDR 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 273 TVMANVFL-LIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15432  247 GKMVALFYgIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 33-294 1.45e-38

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 136.95  E-value: 1.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15226    7 FSLFYVAtvlGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15226   87 EMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DnriNSVLGLFALfSTTGFDCPC----ILLSYVLIIRSVLSiASSDERQKAFNTCISHISAVAIFYIPLISLslvhrYGH 265
Cdd:cd15226  167 D---TYVLELMVV-ANSGLISLVcfllLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFI-----YVW 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 112983541 266 SAPAF-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15226  237 PFSTFpVDKFLAVFYTVITPLLNPIIYTLR 266
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 35-301 2.62e-38

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 136.53  E-value: 2.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15421   12 LVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR-- 192
Cdd:cd15421   92 ALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSay 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 -----INSVLGLFALFSTtgfdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSA 267
Cdd:cd15421  172 etvvyVSGVLFLLIPFSL-------ILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSP 244

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 112983541 268 PafvHTVMANVFL-LIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15421  245 E---QDKVVSVFYtILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 35-305 5.26e-38

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 136.07  E-value: 5.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15418   13 ILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15418   93 AAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPAfvHTV 274
Cdd:cd15418  173 ELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDR--DKV 250

                        250       260       270
                 ....*....|....*....|....*....|.
gi 112983541 275 MANVFLLIPPVLNPIIYSVKTKQIRKAILKV 305
Cdd:cd15418  251 VALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 31-294 6.98e-38

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 135.26  E-value: 6.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFME 110
Cdd:cd15940    8 LVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 111 SGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTD 190
Cdd:cd15940   88 IFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 191 NRINSVLgLFALFSTTGFDCPCILL-SYVLIIRSVLSIaSSDERQKAFNTCISHISAVAIFYIPLISLslvhrYGHSAPA 269
Cdd:cd15940  168 TYLIDIL-IVSNSGLISLVCFVALLgSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFI-----YTRPSTS 240

                        250       260
                 ....*....|....*....|....*.
gi 112983541 270 F-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15940  241 FsEDKVVSVFYTVVTPLLNPIIYTLR 266
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 14-306 2.01e-37

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 134.91  E-value: 2.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  14 FLLTGIPGLRAAQVWISIPFCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEARE 90
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVnvvGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  91 INLNACIAQMFFLHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSS 170
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 171 LVLSHSYCYHVDVIQLSCTDNRINSVL----GLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISA 246
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILlyvfCGFVEMSSLSI----ILISYLFILVAILRMRSAEGRRKAFSTCASHFTG 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 112983541 247 VAIFYIPLISLSLVhryGHSAPAFVHTVMANVFL-LIPPVLNPIIYSVKTKQIRKAILKVL 306
Cdd:cd15944  237 VTLFYGTVIFMYLR---PTSVYSLDQDKWASVFYtVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 31-302 5.58e-37

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 133.31  E-value: 5.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLS-------GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15405    1 IPLFFLFLGiyvvtvvGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDV 183
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYiplISLSLVHRY 263
Cdd:cd15405  161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFF---GSGAFMYLK 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 112983541 264 GHSAPAFVHTVMANVF-LLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15405  238 PSSVGSVNQGKVSSVFyTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 35-302 9.79e-37

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 132.56  E-value: 9.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15942   12 LLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15942   92 TVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGHSAPafVHTV 274
Cdd:cd15942  172 ELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL--RPGSQDP--LDGV 247

                        250       260
                 ....*....|....*....|....*...
gi 112983541 275 MANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15942  248 VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 35-302 1.12e-35

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 129.91  E-value: 1.12e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15428   12 LMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR-- 192
Cdd:cd15428   92 SVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHqa 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 --INSVLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRyghSAPAF 270
Cdd:cd15428  172 emAMFIMCVFTLVLPVLL----ILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK---SSTSK 244

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112983541 271 VHTVMANVF-LLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15428  245 EYDKMISVFyIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 33-294 1.54e-35

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 129.14  E-value: 1.54e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15946    7 FLLIYLSillGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGIT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15946   87 ECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINS----VLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLvhRYGH 265
Cdd:cd15946  167 DTSLNEmvdfVLGVIVLVVPLSL----ILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYM--RPGS 240

                        250       260
                 ....*....|....*....|....*....
gi 112983541 266 SAPAFVHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15946  241 NYSPERDKKISLFYNVFTALLNPVIYSLR 269
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 35-294 9.15e-35

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 127.10  E-value: 9.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15430   12 LVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd15430   92 AVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLN 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 195 SVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapAFVHTV 274
Cdd:cd15430  172 EIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNA--QISDKL 249

                        250       260
                 ....*....|....*....|
gi 112983541 275 MANVFLLIPPVLNPIIYSVK 294
Cdd:cd15430  250 ITLFYGVVTPMLNPIIYSLR 269
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 33-302 4.59e-33

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 122.98  E-value: 4.59e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15433   10 FYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15433   90 LLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 INSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFY--IPLISLSLVHRYGHSAPAF 270
Cdd:cd15433  170 TTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYgsAIYTYLQPIHRYSQAHGKF 249

                        250       260       270
                 ....*....|....*....|....*....|..
gi 112983541 271 VhtvmANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15433  250 V----SLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 33-294 6.03e-33

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 122.44  E-value: 6.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15936    7 FLLVYLTtwlGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQI-------GTIVLIRNVAVMLPvvlfvkrLSFCSSLVLSHSYCYHVD 182
Cdd:cd15936   87 EVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLvagswlgGFAHSIVQVALLLQ-------LPFCGPNVLDNFYCDVPQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 183 VIQLSCTDNRINSVL-----GLFALFsttgfdCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISL 257
Cdd:cd15936  160 VIKLACTDTFLLELLmvsnsGLVTLL------IFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYI 233

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 112983541 258 slvhrYGHSAPAF-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15936  234 -----YARPFQTFpMDKAVSVLYTVITPMLNPMIYTLR 266
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 35-294 2.11e-32

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 120.88  E-value: 2.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15913   12 ILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTD---- 190
Cdd:cd15913   92 SVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPapgt 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 191 NRINSVLGLFALFSTTGFdcpcILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHsaPAF 270
Cdd:cd15913  172 ELICYTLSSLIIFGTFLF----ILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN--STG 245

                        250       260
                 ....*....|....*....|....
gi 112983541 271 VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15913  246 MQKIVTLFYSVVTPLLNPLIYSLR 269
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 35-302 1.34e-29

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 113.79  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHE-PMYYFLSMLSITDLSLSLCTLSTTL-GVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15941   12 LLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYAFHFLASTECF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNR 192
Cdd:cd15941   92 LYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 193 INSVLGLFALFSTTGFDCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPAfvh 272
Cdd:cd15941  172 INELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAG--- 248

                        250       260       270
                 ....*....|....*....|....*....|
gi 112983541 273 tVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15941  249 -APAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 38-294 1.91e-29

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 112.94  E-value: 1.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHE-PMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLA 116
Cdd:cd15935   15 LLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 117 MAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCTDNRINSV 196
Cdd:cd15935   95 MAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 197 L-----GLFALFsttgfdCPCILLSYVLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapafV 271
Cdd:cd15935  175 LmvansGLLSLV------CFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS----V 244

                        250       260
                 ....*....|....*....|...
gi 112983541 272 HTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15935  245 DKVASVFYTLITPALNPLIYTLR 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 33-294 5.04e-27

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 106.50  E-value: 5.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLS---GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFM 109
Cdd:cd15938    7 FLLAYTMvlvGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 110 ESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15938   87 EMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGL--FALFSTTGFdcPCILLSYVLIIrsvLSIASSDERQKAFNTCISHISAVAIFYIPLISLslvhrYGHSA 267
Cdd:cd15938  167 DTCVTELLMVsnSGLISTVCF--VVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFI-----YARPF 236

                        250       260
                 ....*....|....*....|....*...
gi 112983541 268 PAF-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15938  237 STFpVDKHVSVLYNVITPMLNPLIYTLR 264
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 31-294 1.40e-26

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 105.59  E-value: 1.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFME 110
Cdd:cd15937    8 LLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 111 SGVLLAMAFDRFVAICDPLRYTTILT-NARIAQIGTIVLIRNVAVMLPVVLFVkRLSFCSSLVLSHSYCYHVDVIQLSCT 189
Cdd:cd15937   88 MFLLVAMAYDRYVAICKPLHYTTVVNrRVCCVLVGASWAGGFIHSIIQVALII-RLPFCGPNVLDNFFCDITQVIKLACT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLSYVLIIrSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLslvhrYGHSAPA 269
Cdd:cd15937  167 NTYTVELLMFSNSGLVILLCFLLLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYI-----YARPFRS 240

                        250       260
                 ....*....|....*....|....*.
gi 112983541 270 F-VHTVMANVFLLIPPVLNPIIYSVK 294
Cdd:cd15937  241 FpMDKVVAVFHTVIFPLLNPMIYTLR 266
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 40-291 1.51e-21

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 91.59  E-value: 1.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541   40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTL-STTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAMA 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLpFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  119 FDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSlvlSHSYCYHVDVIQLSCTdnrinsvLG 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSKP-------VS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  199 LFALFSTTGFDCPC--ILLSYVLIIRSVLSIASSDER-------QKAFNTCISHISAVAIFYIPLISLSLVHRYGHSAPA 269
Cdd:pfam00001 151 YTLLISVLGFLLPLlvILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCEL 230

                         250       260
                  ....*....|....*....|....*.
gi 112983541  270 FVHTVMA----NVFLLIPPVLNPIIY 291
Cdd:pfam00001 231 SRLLDKAlsvtLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 38-294 1.87e-15

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 75.02  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAM 117
Cdd:cd00637   13 LVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 118 AFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFcsslvlshsycYHVDVIQLSCTDNRINSVL 197
Cdd:cd00637   93 SVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-----------GGYCCCCLCWPDLTLSKAY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 198 GLFALFSTTGFDCPCILLSYVLIIRSVL--------------SIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRY 263
Cdd:cd00637  162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVF 241

                        250       260       270
                 ....*....|....*....|....*....|...
gi 112983541 264 GHSAPAFVHTV--MANVFLLIPPVLNPIIYSVK 294
Cdd:cd00637  242 GPDPSPLPRILyfLALLLAYLNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 28-302 1.58e-09

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 57.57  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  28 WISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLH 104
Cdd:cd14967    1 LLAVFLSLIILvtvFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNAR-IAQIGTIVLIRNVAVMLPVVLFVKRLSFCSslvlSHSYCYHvdv 183
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRaLIMIAAVWVYSLLISLPPLVGWRDETQPSV----VDCECEF--- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 iqlscTDNRInsvlglFALFSTT-GFDCPCILLS--YVLIIRsvlsIASSDerQKAFNTCISHISAVAIFYIPLISLSLV 260
Cdd:cd14967  154 -----TPNKI------YVLVSSViSFFIPLLIMIvlYARIFR----VARRE--LKAAKTLAIIVGAFLLCWLPFFIIYLV 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 112983541 261 hrYGHSAPAFVHTVMANVFLLIPPV---LNPIIYSVKTKQIRKAI 302
Cdd:cd14967  217 --SAFCPPDCVPPILYAVFFWLGYLnsaLNPIIYALFNRDFRRAF 259
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 31-167 1.03e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 52.36  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYL-------SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNA-CIAQMFF 102
Cdd:cd14979    1 VLVTAIYVaifvvgiVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGgCKLYYFL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112983541 103 LHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSF 167
Cdd:cd14979   81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYL 145
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 29-141 3.95e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 50.37  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  29 ISIPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFeareiNLNACIAQMFFLHGFTF 108
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLV-----SLTPSPATWLLRKGSLV 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 112983541 109 MeSGV-----LLAMAFDRFVAICDPLRYTTILTNARIA 141
Cdd:cd14972   79 L-SLLasaysLLAIAVDRYISIVHGLTYVNNVTNKRVK 115
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 34-131 1.41e-06

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 48.77  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  34 CLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLgvLW-----FEAREInlnAC----IAQMFFLH 104
Cdd:cd15196   11 LVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQL--IWdityrFYGGDL---LCrlvkYLQVVGMY 85

                         90       100
                 ....*....|....*....|....*..
gi 112983541 105 GFTFmesgVLLAMAFDRFVAICDPLRY 131
Cdd:cd15196   86 ASSY----VLVATAIDRYIAICHPLSS 108
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 38-233 1.57e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 48.83  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWfeAREINL---NACIAQMFFLHGFTFMESGVL 114
Cdd:cd14997   15 VLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETW--AREPWLlgeFMCKLVPFVELTVAHASVLTI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKrlsfcsslvlsHSYCYHVDVIQLSCTDNRIN 194
Cdd:cd14997   93 LAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITE-----------FKEEDFNDGTPVAVCRTPAD 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 112983541 195 SVLGLFALFSTTG--FDCPCILLS--YVLIIRSVLSIASSDER 233
Cdd:cd14997  162 TFWKVAYILSTIVvfFVVPLAILSglYSVICRRLVGHPALESR 204
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 38-167 6.07e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 47.07  E-value: 6.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTL-----GVLWFEAreinLNACIAQMFFLHGFTFMESG 112
Cdd:cd15005   15 LAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMasvrhGSGWIYG----ALSCKVIAFLAVLFCFHSAF 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSF 167
Cdd:cd15005   91 TLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTF 145
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 29-140 6.91e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 46.71  E-value: 6.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  29 ISIPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCtLSTTLGVLWfEAREINLN--ACIAQMFFLHGF 106
Cdd:cd15928    6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLV-LPLDLYRLW-RYRPWRFGdlLCRLMYFFSETC 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 112983541 107 TFMESGVLLAMAFDRFVAICDPLRYTTILTNARI 140
Cdd:cd15928   84 TYASILHITALSVERYLAICHPLRAKVLVTRGRV 117
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 34-301 1.08e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 46.13  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  34 CLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV 113
Cdd:cd15096   11 FIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 114 LLAMAFDRFVAICDPLRYTTILT--NARIAQIGT--IVLIRNVAVMlpvvlFVKRLSFCSSLVLSHSYCYHvdviqlscT 189
Cdd:cd15096   91 LVLMSLDRYLAVVHPITSMSIRTerNTLIAIVGIwiVILVANIPVL-----FLHGVVSYGFSSEAYSYCTF--------L 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 190 DNRINSVLGLFALFSTTGFDCPCILLS--YVLIIRSVL---------SIASSDERQKAFNTCISHISAVAIFYIPLISLS 258
Cdd:cd15096  158 TEVGTAAQTFFTSFFLFSYLIPLTLICvlYMLMLRRLRrqkspggrrSAESQRGKRRVTRLVVVVVVVFAICWLPIHIIL 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 112983541 259 LVHRYGH---SAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15096  238 LLKYYGVlpeTVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKA 283
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 34-153 1.30e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 45.94  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  34 CLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV 113
Cdd:cd15351   11 GLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTMICSSV 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 112983541 114 LLAMAF------DRFVAICDPLRYTTILTNARIAQIGTIVLIRNVA 153
Cdd:cd15351   91 VSSLSFlgaiavDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTV 136
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 27-302 1.32e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 45.77  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIpFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLN-ACIAQMFFLHG 105
Cdd:cd15337    5 IYIAI-VGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIWGKvACELYGFAGGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 106 FTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRlsfcsslvlshsycYHVDVIQ 185
Cdd:cd15337   84 FGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGR--------------YVPEGFQ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 186 LSCT--------DNRINSvLGLFALfsttGFDCP--CILLSYVLIIRSVL---------------SIASSDERQKAFNTC 240
Cdd:cd15337  150 TSCTfdylsrdlNNRLFI-LGLFIF----GFLCPllIIIFCYVNIIRAVRnhekemtqtaksgmgKDTEKNDARKKAEIR 224

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112983541 241 ISHISAVAIF-----YIPLISLSLVHRYGHSApaFVHTVMANVfllipPVL--------NPIIYSVKTKQIRKAI 302
Cdd:cd15337  225 IAKVAIILISlfllsWTPYAVVALLGQFGPAY--WITPYVSEL-----PVMfakasaiyNPIIYALSHPKFRAAL 292
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 34-170 3.29e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 44.90  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  34 CLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAqMFFLHGfTFMESGV 113
Cdd:cd14993   11 FLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA-VPYLQG-VSVSASV 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 112983541 114 --LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSS 170
Cdd:cd14993   89 ltLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISS 147
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 33-160 3.96e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 3.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWfEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd15053   10 LPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEV-NGGKWYLGPILCDIYIAMDVMCSTAS 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 V--LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVL 160
Cdd:cd15053   89 IfnLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLF 138
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 33-302 7.84e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 43.35  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESG 112
Cdd:cd14969   10 IGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSIS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 VLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIrNVAVMLPVVLFVKRlsfcsslvlshsycYHVDVIQLSC---- 188
Cdd:cd14969   90 TLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLY-GLFWALPPLFGWSS--------------YVPEGGGTSCsvdw 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 189 TDNRINSVLGLFALFsTTGFDCP--CILLSYVLIIRSVLSIASSD---------------ERQKAFNTCIShISAVAIFY 251
Cdd:cd14969  155 YSKDPNSLSYIVSLF-VFCFFLPlaIIIFCYYKIYRTLRKMSKRAarrknsaitkrtkkaEKKVAKMVLVM-IVAFLIAW 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 112983541 252 IP--LISLSLVHRYGHSAPAFVHTVMAnVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd14969  233 TPyaVVSLYVSFGGESTIPPLLATIPA-LFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 24-139 8.11e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 43.38  E-value: 8.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  24 AAQVWISIPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLctLSTTLGVLWFEAREINLNACIAQMFFL 103
Cdd:cd15069    1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGL--FAIPFAITISLGFCTDFHSCLFLACFV 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 112983541 104 HGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNAR 139
Cdd:cd15069   79 LVLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKR 114
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 32-302 8.81e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.20  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  32 PFCLLY-------LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACiAQMFFLH 104
Cdd:cd15012    1 IFIILYtlvfcccFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLC-RMYQFVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMES-GVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFcssLVLSHSYCYHVDV 183
Cdd:cd15012   80 SLSYTASiGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEI---LVTQDGQEEEICV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 184 IQLSCTDNRINSVLGLFALFSTTgfdcPCILLSYVLIIRSVLSIASSDE-RQKAFNTCISHISAVAIFYIP-----LISL 257
Cdd:cd15012  157 LDREMFNSKLYDTINFIVWYLIP----LLIMTVLYSKISIVLWKSSSIEaRRKVVRLLVAVVVSFALCNLPyharkMWQY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 112983541 258 SLVHRYGHSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15012  233 WSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 41-147 1.01e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 43.25  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  41 NSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAR--------EINLNACIAQMFFLHGFTFMESg 112
Cdd:cd15103   18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGylvprdsfEQHIDNVIDSMICSSLLASICS- 96

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 112983541 113 vLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIV 147
Cdd:cd15103   97 -LLAIAVDRYITIFYALRYHSIMTVRRAGVIITAI 130
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 33-160 1.20e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 42.73  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCT-----LSTTLGVLWFEAREinlnacIAQMFflHGFT 107
Cdd:cd15067    9 FCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVmpfsiLHEMTGGYWLFGRD------WCDVW--HSFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112983541 108 FMESGV----LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVL 160
Cdd:cd15067   81 VLASTAsilnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIA 137
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 40-140 1.66e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 42.63  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSL----CTLSTTLGVlwfearEINLNACIAQMFFLHGFTFMESGVLL 115
Cdd:cd14968   17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGAlaipLAILISLGL------PTNFHGCLFMACLVLVLTQSSIFSLL 90

                         90       100
                 ....*....|....*....|....*
gi 112983541 116 AMAFDRFVAICDPLRYTTILTNARI 140
Cdd:cd14968   91 AIAIDRYLAIKIPLRYKSLVTGRRA 115
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 26-224 2.26e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 42.23  E-value: 2.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  26 QVWISIPFCLLYLSGNSMILLVIVReQSLHEPMYYFLSMLSITDLSLSLCTLSTTLgvLWFEAREINLNACIAQMFFLH- 104
Cdd:cd14978    3 YGYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFL--LPYIADYSSSFLSYFYAYFLPy 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 ----GFTFMESGVLL--AMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSYC 178
Cdd:cd14978   80 iyplANTFQTASVWLtvALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 112983541 179 YHVDVIQLSCTDNRINSVlgLFALFSTTGfdcPCILLSY--VLIIRSV 224
Cdd:cd14978  160 IPTLLRQNETYLLKYYFW--LYAIFVVLL---PFILLLIlnILLIRAL 202
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 40-140 2.36e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 42.03  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAMAF 119
Cdd:cd15197   17 GNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSI 96

                         90       100
                 ....*....|....*....|.
gi 112983541 120 DRFVAICDPLRYTTILTNARI 140
Cdd:cd15197   97 DRYDAICHPMNFSQSGRQARV 117
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 35-139 2.68e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 41.85  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREInlnaCIAQMFFLHGFTFMESGV- 113
Cdd:cd15354   12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL----VIEDAFVRHIDNVFDSLIc 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 112983541 114 ---------LLAMAFDRFVAICDPLRYTTILTNAR 139
Cdd:cd15354   88 isvvasmcsLLAIAVDRYVTIFYALRYHNIMTVRR 122
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 38-130 5.91e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 40.82  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNAC----IAQMFFLHGFTFMesgv 113
Cdd:cd14986   15 LVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCrivkYLQVVGLFASTYI---- 90

                         90
                 ....*....|....*..
gi 112983541 114 LLAMAFDRFVAICDPLR 130
Cdd:cd14986   91 LVSMSLDRYQAIVKPMS 107
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 40-157 6.41e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 40.78  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAMAF 119
Cdd:cd15083   17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAV 96

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 112983541 120 DRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLP 157
Cdd:cd15083   97 DRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP 134
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 33-302 6.47e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 40.72  E-value: 6.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIaqmffLHGFTFMESG 112
Cdd:cd15074   10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCV-----FYGFCGFLFG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 113 V-----LLAMAFDRFVAICDPlRYTTILTNARIaqIGTIVLIRNVAvmlpvvlfvkrLSFCSSLVLSHSYcYHVDVIQLS 187
Cdd:cd15074   85 CcsintLTAISIYRYLKICHP-PYGPKLSRRHV--CIVIVAIWLYA-----------LFWAVAPLVGWGS-YGPEPFGTS 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 188 CTDN---RINSVLGLFALFSTT--GFDCPC--ILLSYVLIIRSV----LSIASSDERQKAFNTCISHISAVAI-----FY 251
Cdd:cd15074  150 CSIDwtgASASVGGMSYIISIFifCYLLPVliIVFSYVKIIRKVkssrKRVAGFDSRSKRQHKIERKVTKVAVlicagFL 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 112983541 252 I-----PLISLSLVHRYGHSAPAFVhTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15074  230 IawtpyAVVSMWSAFGSPDSVPILA-SILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
 36-302 7.40e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 40.55  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  36 LYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLctlstTLGVLWFEARE-----INLNACIAQMFFLHGFTFME 110
Cdd:cd15082   26 LSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSL-----TGGTISFLTNArgyffLGVWACVLEGFAVTFFGIVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 111 SGVLLAMAFDRFVAICDPLryttiltnariaqiGTIVLIRNVAVMlpVVLFVKRLSFCSSL--VLSHSyCYHVDVIQLSC 188
Cdd:cd15082  101 LWSLAVLAFERFFVICRPL--------------GNIRLQGKHAAL--GLLFVWTFSFIWTIppVLGWS-SYTVSKIGTTC 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 189 TDNRINSVL---GLFALFSTTGFDCP--CILLSYVLIIRSV---------LSIASSDERQK---------AFNTCISHIS 245
Cdd:cd15082  164 EPNWYSGNMhdhTYIITFFTTCFILPlgVIFVSYGKLLQKLrkvsntqgrLGNARKPERQVtrmvvvmivAFMVCWTPYA 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 112983541 246 AVAIFYIPLISLSLVHRYGhSAPAFVHTVMAnvfllippVLNPIIYSVKTKQIRKAI 302
Cdd:cd15082  244 AFSILVTAHPTIHLDPRLA-AIPAFFSKTAA--------VYNPIIYVFMNKQFRKCL 291
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 35-147 8.13e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 40.28  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV- 113
Cdd:cd15353   12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVNIDNVIDSVICSSLLa 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 112983541 114 ----LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIV 147
Cdd:cd15353   92 sicsLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCI 129
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 38-160 8.34e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 40.35  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSttLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL--L 115
Cdd:cd15330   15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP--MAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILhlC 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 112983541 116 AMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVL 160
Cdd:cd15330   93 AIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML 137
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 33-139 9.06e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 40.26  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTL--STTLGVL--WFEAR-------EINLNACIAQMF 101
Cdd:cd15326   10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLpfSATLEILgyWVFGRifcdiwaAVDVLCCTASIL 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 112983541 102 flhgftfmesgVLLAMAFDRFVAICDPLRYTTILTNAR 139
Cdd:cd15326   90 -----------SLCAISIDRYIGVRHSLQYPTIVTRKR 116
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
 23-302 1.13e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 39.76  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  23 RAAQVWISIPFCLLYLSgNSMILLVIVREQSLHEPMYYFLSMLSITDLslsLCTLSTTLGVLWFEAREINLNAciAQMFF 102
Cdd:cd15102    1 GATSVVFVAICCFIVLE-NLLVLIAIWRHMKFHRPMYYFLGNLALSDL---LAGAAYLANILLSGARTLRLSP--AQWFL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 103 LHGFTFMESGV----LLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLF--VKRLSFCSSLVLSHS 176
Cdd:cd15102   75 REGSMFVALSAsvfsLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWncLGALDACSTVLPLYS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 177 YCYhvdviqlsctdnrINSVLGLFALFSTTgfdcpcILLSYVLIIRSVLSIASSDERQKA-------FNTCISHISAVAI 249
Cdd:cd15102  155 KHY-------------VLFCVTIFAGILAA------IVALYARIYCLVRASGRKATRASAsprslalLKTVLIVLLVFIA 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 112983541 250 FYIPLISLSLVHRYG--HSAPAFVHTVMANVFLLIPPVLNPIIYSVKTKQIRKAI 302
Cdd:cd15102  216 CWGPLFILLLLDVACpvKTCPILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 31-301 1.18e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 39.82  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYL-------SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFE-AREINLNACIAQMFF 102
Cdd:cd15133    1 FPVCLTYLlifvvgvVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNyPFLLGSGGCYFKTFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 103 LHGFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVlFVKRLSFCSSLVLSHSYCYHVD 182
Cdd:cd15133   81 FETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNT-SLHGIKFLGSGVPASAQCTVRK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 183 VIQLSCTDNRINSVlgLFALFSTTGFDCPCILLSYVL--------------IIRSVLSIASSDERQKAFNTCISHISAV- 247
Cdd:cd15133  160 PQAIYNMIPQHTGH--LFFVLPMAVISVLYLLMALRLarergldatgagskIGTRTGQLLQHPRTRAQVTKMLFILVVVf 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 112983541 248 ----AIFYIPLISLSLVHRYG---HSAPAFVHtVMANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15133  238 aicwAPFHIDRLMWSFISDWTdnlHEVFQYVH-IISGVFFYLSSAVNPILYNLMSTRFREM 297
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 35-299 1.22e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 115 LAMAFDRFVAICDPlryttiltnariaqIGTIVLIRNVAVMLPVVLFVKRLSFCSSLVLSHSyCYHVDVIQLSCT---DN 191
Cdd:cd15085   92 TLLAYERYNVVCKP--------------MGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWS-SYGPEGVQTSCSigwEE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 192 RINSVLGLFALFSTTGFDCPC--ILLSYVLIIRSVLSIASSDERQ----------KAFNTCISHISAVAIFYIP--LISL 257
Cdd:cd15085  157 RSWSNYSYLILYFLMCFVIPVaiIGFSYGNVLRSLHKLNKKIEQQggkncpeeeeRAVIMVLAMVIAFLICWLPytVFAL 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 112983541 258 SLVHRYGHSAPAFVHTvMANVFLLIPPVLNPIIYSVKTKQIR 299
Cdd:cd15085  237 IVVVNPELSISPLAAT-MPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 35-140 1.34e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 39.76  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLctLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15070   12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGV--LVIPLAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSL 89

                         90       100
                 ....*....|....*....|....*.
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARI 140
Cdd:cd15070   90 LAIAVDRYLRVKLTVRYRIVTTQRRI 115
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
 40-156 1.48e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 39.50  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541   40 GNSMILLVIVREQSLHEPMYYFLSMLSITDLslsLCTLSTTL-GVLWFEAREINLNACIAQMFFLHGFTFMESGVLLAMA 118
Cdd:pfam10320   7 GNVLMIHLTFRKKKLRSKCSILICVQCIAHL---ICLCGEIVfVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLMLMIG 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 112983541  119 FDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVML 156
Cdd:pfam10320  84 IDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITV 121
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 35-136 1.59e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 39.74  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLS----TTLGVLWFEAR-------EINLNACIAQMFFL 103
Cdd:cd15317   12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfsmiRTVETCWYFGDlfckfhtGLDLLLCTTSIFHL 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 112983541 104 hgftfmesgvlLAMAFDRFVAICDPLRYTTILT 136
Cdd:cd15317   92 -----------CFIAIDRYYAVCDPLRYPSKIT 113
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
 29-301 1.89e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 39.48  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  29 ISIPFCLLYL---SGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCtLSTTLGVLWfEAREINLNACIAQMFFLHG 105
Cdd:cd15131    3 ITVTCVLLFVvgvTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLC-MPLDLYRLW-QYRPWNFGDLLCKLFQFVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 106 FTFMESGVL--LAMAFDRFVAICDPLRYTTILTNARIAQigtivlirnvavmlpVVLFVKRLSFCSS---LVL----SHS 176
Cdd:cd15131   81 ESCTYSTILniTALSVERYFAICFPLRAKVVVTKRRVKL---------------VILVLWAVSFLSAgpiFVLvgveHEN 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 177 YCYHVDVIQLSCTDNRINS-VLGLFALFSTTGFDCP--CILLSYVLIIRSVL------SIASSDERQKAFNTCISHIsAV 247
Cdd:cd15131  146 GTNPIDTNECKATEYAVRSgLLTIMVWVSSVFFFLPvfCLTVLYSLIGRKLWrrrrenIGPNASHRDKNNRQTVKML-AV 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112983541 248 AIFYIPLISLSL-VHRY--GHSAPAF---------VHTVMANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15131  225 VVFAFVLCWLPFhVGRYlfSKSFEAGsleialisqYCNLVSFVLFYLSAAINPILYNIMSKKYRVA 290
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
 38-167 2.21e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.16  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITD-LSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVLLA 116
Cdd:cd15217   15 LAGNLIVSLLVLKDRALHKAPYYFLLDLCLADtIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLFC 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 112983541 117 MAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSF 167
Cdd:cd15217   95 ISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKF 145
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 35-130 2.41e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.03  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLgvLW---FEAREINLNACIAQMFFLHGFtFMES 111
Cdd:cd15387   12 FLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQL--IWditFRFYGPDFLCRLVKYLQVVGM-FAST 88

                         90
                 ....*....|....*....
gi 112983541 112 GVLLAMAFDRFVAICDPLR 130
Cdd:cd15387   89 YMLLLMSIDRCLAICQPLR 107
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
 41-301 2.73e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 38.62  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  41 NSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLctLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV--LLAMA 118
Cdd:cd15333   22 NAFVIATIYLTRKLHTPANYLIASLAVTDLLVSI--LVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASIlhLCVIA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 119 FDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPvVLFVKRLSfcsslvlshsycyhvdvIQLSCTDNRINSVLG 198
Cdd:cd15333  100 LDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLP-PFFWRQAK-----------------AEEEVSECVVNTDHI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 199 LFALFSTTG-FDCPCILLsyvLIIRSVLSIASSDERQKAFNTCISHISAVAIFYIPLISLSLVHRYGHSApAFVHTVMAN 277
Cdd:cd15333  162 LYTVYSTVGaFYIPTLLL---IALYGRIYVEARARERKATKTLGIILGAFIVCWLPFFIISLVLPICKDA-CWFHLAIFD 237

                        250       260
                 ....*....|....*....|....*..
gi 112983541 278 VFL---LIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15333  238 FFTwlgYLNSLINPIIYTMSNEDFKQA 264
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 31-178 2.82e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 38.64  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFME 110
Cdd:cd15202    8 SFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVS 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 111 SGVLLAMAFDRFVAICDPLRYTTILTNAR--IAQIGTIVLirnvAVMLPVVLFVKRLSFCSSLVLSHSYC 178
Cdd:cd15202   88 AYTLTAIAVDRYQAIMHPLKPRISKTKAKfiIAVIWTLAL----AFALPHAICSKLETFKYSEDIVRSLC 153
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 38-147 3.51e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 38.22  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  38 LSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNA--------CIAQMFFLHGFTFM 109
Cdd:cd15350   15 LLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSLFCLSLLGSI 94

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 112983541 110 ESgvLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIV 147
Cdd:cd15350   95 FS--ILAIAADRYITIFHALRYHNIMTMRRTLVILAII 130
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 27-139 3.66e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.38  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYLSGNSMILLVIVREQSLHE--PMYYFLSMLSITDLsLSLCTLSTTLGVLWFEAREINLNACIAQMF-FL 103
Cdd:cd14981    4 PAPPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDL-LGILLTSPVVLAVYASNFEWDGGQPLCDYFgFM 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 112983541 104 HGFTFMESG-VLLAMAFDRFVAICDPLRYTTILTNAR 139
Cdd:cd14981   83 MSFFGLSSLlIVCAMAVERFLAITHPFFYNSHVKKRR 119
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 35-167 3.91e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 38.31  E-value: 3.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  35 LLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGVL 114
Cdd:cd15978   12 LLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNL 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 112983541 115 LAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKRLSF 167
Cdd:cd15978   92 VAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
 27-141 4.54e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 38.27  E-value: 4.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPFCLLYL---SGNSMILLVIVRE-QSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREINLNACIAQMFF 102
Cdd:cd15097    1 VIVPVVFSLIFLlgtVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 112983541 103 LHGFTFMESGVLLAMAFDRFVAICDPLRYTTILT--NARIA 141
Cdd:cd15097   81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTprNAVAA 121
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
 31-159 6.16e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 37.51  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  31 IPFCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTL-----STTLGVLWfearEINLNACIAQMFFLHG 105
Cdd:cd15308    8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLplyvySEFQGGVW----TLSPVLCDALMTMDVM 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 112983541 106 FTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVV 159
Cdd:cd15308   84 LCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVI 137
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 33-154 6.43e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 37.70  E-value: 6.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  33 FCLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTL--STTLGV-------LWFEAREINLNACIAQMFFL 103
Cdd:cd15051   10 IILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLpfSAIYELrgewplgPVFCNIYISLDVMLCTASIL 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 112983541 104 HgftfmesgvLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAV 154
Cdd:cd15051   90 N---------LFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAV 131
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 29-301 7.05e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 37.70  E-value: 7.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  29 ISIPFCLLYLSG---NSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLCTLSTTLGVLWFEAREI-NLNACIAQMFFLH 104
Cdd:cd15134    3 ITIIYGIIFVTGvvgNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVfGEVFCKLRAFLSE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 105 GFTFMESGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVK----RLSFCSSLVLSHSYcyh 180
Cdd:cd15134   83 MSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRivylEYPPTSGEALEESA--- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 181 vdviqlSCT-DNRINSVLGLFALFSTTGFDCPCILLS--YVLI---IRS-------VLSIASSDERQKAFNTCISHISAV 247
Cdd:cd15134  160 ------FCAmLNEIPPITPVFQLSTFLFFIIPMIAIIvlYVLIglqLRRstllrrgQRSVSGGRRSSQSRRTVLRMLVAV 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112983541 248 AI-FYI---PLISLSLVHRYGHS---APAFVHTVM---ANVFLLIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15134  234 VVaFFIcwaPFHAQRLLTVYAKNmtpPYLFINRILfyiSGVLYYVSSTVNPILYNVMSAKYRQA 297
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
 41-301 7.09e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 37.62  E-value: 7.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  41 NSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLctLSTTLGVLWFEAREINLNACIAQMFFLHGFTFMESGV--LLAMA 118
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAV--LVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSIlhLSAIA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 119 FDRFVAICDPLRYTTILTNARIAQIGTIVLIRNVAVMLPVVLFVKR-LSFCSSLVLSHSYCyhvdviqlsctdnrinsvl 197
Cdd:cd15334   96 LDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQtTSREDECIIKHDHI------------------- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541 198 gLFALFSTtgFDCPCILLSYVLIIRSVLSIASSDERqKAFNTCISHISAVAIFYIPLISLSLVHRYGHSapAFVHTVMAN 277
Cdd:cd15334  157 -VFTIYST--FGAFYIPLALILILYYKIYRAATRER-KAATTLGLILGAFVICWLPFFVKEVIVNTCDS--CYISEEMSN 230

                        250       260
                 ....*....|....*....|....*..
gi 112983541 278 VFL---LIPPVLNPIIYSVKTKQIRKA 301
Cdd:cd15334  231 FLTwlgYINSLINPLIYTIFNEDFKKA 257
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 27-149 8.93e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 37.43  E-value: 8.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  27 VWISIPF---CLLYLSGNSMILLVIVREQSLHEPMYYFLSMLSITDLSLSLC--------------TLSTTLGVLWFEAR 89
Cdd:cd15058    1 PGLLLLLaliILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLvvplgativvtgkwQLGNFWCELWTSVD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 112983541  90 EINLNACIaqmfflhgftfmesGVLLAMAFDRFVAICDPLRYTTILTNARIAQIGTIVLI 149
Cdd:cd15058   81 VLCVTASI--------------ETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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