NCBI Conserved Domain Search

Conserved domains on [gi|22128983|ref|NP_667185|]

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olfactory receptor family 4 subfamily C member 127 [Mus musculus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

6.05e-162

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.28 E-value: 6.05e-162

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 22128983 260 FHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

6.05e-162

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.28 E-value: 6.05e-162

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 22128983 260 FHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

28-297

2.10e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 128.77 E-value: 2.10e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983    28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTDt 187
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   188 htlgplIAANSGSMCLLIFS-------MLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:pfam13853 162 ------IKVNNIYGLFVVTStfgidslLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFG 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 22128983   260 FHIDKIVSVF----YTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:pfam13853 236 HNVPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

6.05e-162

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.28 E-value: 6.05e-162

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 22128983 260 FHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

21-286

1.18e-126

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 361.91 E-value: 1.18e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                       250       260
                ....*....|....*....|....*.
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15226 242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

21-286

7.19e-118

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 339.84 E-value: 7.19e-118

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI- 258
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSs 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 259 -SFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd13954 242 ySSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

21-286

1.91e-114

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 331.01 E-value: 1.91e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 260 FH--IDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15230 242 YSldQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

21-290

1.65e-113

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 329.03 E-value: 1.65e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPksS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVK 274

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

21-286

9.50e-111

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 321.59 E-value: 9.50e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                       250       260
                ....*....|....*....|....*.
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15936 242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

21-286

1.89e-110

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 320.93 E-value: 1.89e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*.
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15940 242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

6-297

8.84e-109

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 317.77 E-value: 8.84e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   6 EFILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKS 85
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  86 TISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCG 165
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 166 PNIINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVL 244
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128983 245 FFVPCSYLYVRPVISFHI--DKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

7-290

3.28e-108

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 315.80 E-value: 3.28e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   7 FILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKST 86
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  87 ISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGP 166
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 167 NIINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLF 245
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22128983 246 FVPCSYLYVRPVI--SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15408 241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

7-297

6.06e-104

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 305.35 E-value: 6.06e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   7 FILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKST 86
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  87 ISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGP 166
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 167 NIINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLF 245
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTiLRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128983 246 FVPCSYLYVRPVISF--HIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:cd15410 241 HGTILFMYCRPSSSYslDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

21-293

9.25e-103

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 301.82 E-value: 9.25e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI- 258
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSa 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 259 -SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15229 242 sSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

21-286

1.41e-100

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 295.93 E-value: 1.41e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGpLIAANSGSMCLLI-FSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV- 257
Cdd:cd15912 162 KLSCSDTRLIE-LLDFILASVVLLGsLLLTIVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSq 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22128983 258 -ISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15912 241 sSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

21-293

1.71e-100

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 296.10 E-value: 1.71e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV-- 257
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSsg 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15231 242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

21-286

4.38e-100

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 294.78 E-value: 4.38e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLgPLIAANSGSMCLLI-FSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP-- 256
Cdd:cd15911 162 KLSCSDTSLV-ELVTFILSSIVTLPpFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPst 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22128983 257 VISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15911 241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

21-293

3.59e-97

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 287.52 E-value: 3.59e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPViS 259
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPG-S 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 260 FH---IDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15421 241 YHspeQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

20-286

4.64e-97

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 286.86 E-value: 4.64e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPvI 258
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRP-H 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128983 259 SFHI---DKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15237 240 STHSpdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

22-295

7.80e-96

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 284.21 E-value: 7.80e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15411   3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15411  83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 261 HI--DKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15411 243 SLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

22-295

8.97e-96

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 283.87 E-value: 8.97e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 261 HID--KIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15416 243 SMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

19-293

2.10e-95

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 282.96 E-value: 2.10e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  19 QKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFA 98
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIP 178
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 179 LLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV 257
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128983 258 ISFHIDK--IVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15235 241 SSYSADKdrVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

21-295

2.67e-95

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 282.99 E-value: 2.67e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANsgSMCLLIFSMLVA--SYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV 257
Cdd:cd15417 162 SLSCSDTFISQVVLFLV--AVLFGVFSVLVVliSYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22128983 258 I--SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15417 240 SshSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

7-295

4.30e-95

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 282.79 E-value: 4.30e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   7 FILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKST 86
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  87 ISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGP 166
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 167 NIINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLF 245
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22128983 246 FVPCSYLYVRPVISFHI--DKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

21-286

1.95e-94

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 280.30 E-value: 1.95e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPssS 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

11-297

5.47e-94

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 280.02 E-value: 5.47e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  11 GLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFN 90
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  91 GCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIIN 170
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 171 HFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC 249
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22128983 250 SYLYVRPVISFHID--KIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:cd15406 241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

21-286

2.79e-93

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 277.18 E-value: 2.79e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIaQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAvLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqsK 240

                       250       260
                ....*....|....*....|....*....
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

22-286

3.54e-93

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 277.26 E-value: 3.54e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSL--RNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI- 258
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSg 242

                       250       260
                ....*....|....*....|....*....
gi 22128983 259 -SFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15915 243 dSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

21-295

3.79e-93

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 277.27 E-value: 3.79e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgaV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15419 242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

21-286

4.33e-93

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 277.03 E-value: 4.33e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPAL-ATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                       250       260
                ....*....|....*....|....*..
gi 22128983 260 FHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15935 242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

22-295

8.40e-93

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 276.51 E-value: 8.40e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGsmCLLIFSMLVA--SYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI 258
Cdd:cd15413 163 LSCSDTHEKELIILIFAG--FNLISSLLIVlvSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22128983 259 --SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15413 241 shSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

21-295

9.02e-93

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 276.60 E-value: 9.02e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22128983 260 FHI--DKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15409 242 YALdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

21-286

9.58e-93

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 275.98 E-value: 9.58e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15938   2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRnhSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                       250       260
                ....*....|....*....|....*.
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15938 240 PVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

22-290

5.90e-92

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 274.28 E-value: 5.90e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV--I 258
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRsgS 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128983 259 SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVK 274

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

22-295

1.04e-91

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 273.91 E-value: 1.04e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15415   3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15415  83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 261 HID--KIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15415 243 SLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

21-286

1.35e-91

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 273.17 E-value: 1.35e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV-- 257
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPsd 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15227 242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

21-301

1.84e-91

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 273.15 E-value: 1.84e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22128983 260 F--HIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKLLGSNH 301
Cdd:cd15414 242 SslDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

21-286

1.91e-91

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 272.77 E-value: 1.91e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*.
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15937 242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

21-291

3.09e-91

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 272.38 E-value: 3.09e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15228   2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15228 162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128983 260 FHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKR 291
Cdd:cd15228 242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKA 273

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

20-295

2.59e-90

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 270.04 E-value: 2.59e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI 258
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22128983 259 --SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15412 241 eeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

20-286

4.75e-90

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 269.10 E-value: 4.75e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP-- 256
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPps 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22128983 257 VISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

21-290

5.30e-90

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 269.32 E-value: 5.30e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKS-TISFNGCMTQLFAE 99
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGkVISFGGCVAQLYFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI 258
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128983 259 SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15916 242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVK 273

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

21-286

1.17e-89

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 268.00 E-value: 1.17e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPkaI 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15224 242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

22-286

8.50e-88

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 263.33 E-value: 8.50e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22128983 261 HID--KIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15947 243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

7-297

3.78e-87

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 262.80 E-value: 3.78e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   7 FILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKST 86
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  87 ISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGP 166
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 167 NIINHFICDLIPLLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLF 245
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128983 246 FVPCSYLYVRP--VISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:cd15944 241 YGTVIFMYLRPtsVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

21-290

1.27e-86

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 260.72 E-value: 1.27e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 260 F--HIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15420 242 NsaEQEKILSLFYSLFNPMLNPLIYSLRNKQVK 274

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

22-295

5.94e-83

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 251.57 E-value: 5.94e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHT----LGPLIAANSGSMCLLIFSmlvaSYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP 256
Cdd:cd15407 163 LSCSDIHIseivLFFLASFNVFFALLVILI----SYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQP 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22128983 257 VI--SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKK 295
Cdd:cd15407 239 SSshSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

20-293

1.20e-81

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 248.06 E-value: 1.20e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP-- 256
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPkn 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 257 VISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

19-296

1.13e-80

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 245.85 E-value: 1.13e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  19 QKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFA 98
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIP 178
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 179 LLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV 257
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22128983 258 IS--FHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVMKKL 296
Cdd:cd15418 241 SShtPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

22-290

4.06e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 244.25 E-value: 4.06e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--VI 258
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPssVG 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128983 259 SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVK 274

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

21-293

5.06e-79

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 241.18 E-value: 5.06e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--- 256
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrsg 241

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 257 VISFHiDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15424 242 STPDR-DKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

20-286

3.54e-78

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 238.81 E-value: 3.54e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDThTLGPLIAANSGSMCLLIFSMLVA-SYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP- 256
Cdd:cd15430 161 LKLACVDI-SLNEIIMLVGNIIFLVIPLLLICiSYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPk 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128983 257 -VISFHIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15430 240 sKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

22-293

4.11e-78

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 238.87 E-value: 4.11e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISF 260
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15942 243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

21-293

8.05e-78

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 238.21 E-value: 8.05e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALAT-PMYFFLSYLSIIDGFYSSSITPKMIYDLIS-EKSTISFNGCMTQLFA 98
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIP 178
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 179 LLELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPV 257
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

21-286

1.25e-76

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 234.96 E-value: 1.25e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVvLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 260 FHI--DKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15914 242 YSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

21-286

5.27e-76

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 233.36 E-value: 5.27e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAvLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 260 FH--IDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15913 242 NStgMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

20-291

1.85e-74

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 229.67 E-value: 1.85e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI 258
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128983 259 SFHID--KIVSVFYTLVTPLLNPLIYTLRNEEVKR 291
Cdd:cd15432 241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKE 275

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

21-293

8.45e-73

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 225.53 E-value: 8.45e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 260 F--HIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15234 242 HssRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

21-293

1.25e-72

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 225.06 E-value: 1.25e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYV-VILRSLRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLgsV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

21-290

1.39e-72

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 225.05 E-value: 1.39e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP--V 257
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTvFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVK 274

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

20-290

1.51e-72

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 224.67 E-value: 1.51e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPL 179
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 LELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVI 258
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128983 259 SFHID--KIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15433 241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVK 274

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

21-286

8.67e-72

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 222.74 E-value: 8.67e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 22128983 260 F--HIDKIVSVFYTLVTPLLNPLIYTLRN 286
Cdd:cd15946 242 YspERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

21-290

1.65e-68

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 214.63 E-value: 1.65e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 260 FHIDK--IVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15236 242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIK 274

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

21-290

3.62e-57

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 185.57 E-value: 3.62e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDT---HTLGPLIA-ANSGSMCLLIFsmlvASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFF--VPCSYLY 253
Cdd:cd15223 162 SLACGDTtinSIYGLAVAwLIVGSDIILIF----FSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLT 237

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22128983 254 VR--PVISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15223 238 YRfgKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIR 276

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

28-289

3.77e-54

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 177.61 E-value: 3.77e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15950   9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVciflVVAAGIVGFVHGMIQTT----FIAQLPFCGPNIINHFICDLIPLLELA 183
Cdd:cd15950  89 GVLLAMAFDRYVAICHPLRYSAILTSQV----IAQIGLAIVLRALLFMTpltcLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 184 CTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVP-CSYLYVRPV---I 258
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPgLLSIYTQRFgqgV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128983 259 SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15950 245 PPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-289

2.82e-53

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 175.17 E-value: 2.82e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  29 IYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEII 108
Cdd:cd15917  10 MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 109 LLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTDT- 187
Cdd:cd15917  90 VLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTr 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 188 -HTLGPLIAAnsgsMCLLIFSMLV--ASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISFHID 263
Cdd:cd15917 170 vNSIYGLFVA----LLIVGFDLLFiaLSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVP 245

                       250       260       270
                ....*....|....*....|....*....|
gi 22128983 264 K----IVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15917 246 PhvhiLLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

28-289

1.07e-50

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 168.62 E-value: 1.07e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15221   9 SMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTDT 187
Cdd:cd15221  89 AILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 188 --HTLGPLIAANSGSMCLLIFsmLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC--SYLYVR--PVISF 260
Cdd:cd15221 169 tvNIWYGLTVALLTVGLDVVL--IAVSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAffSFLTHRfgRHIPR 246

                       250       260
                ....*....|....*....|....*....
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15221 247 HVHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

28-289

2.89e-48

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 162.16 E-value: 2.89e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTD- 186
Cdd:cd15952  89 AVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASi 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 187 -THTLGPLIAAnsgSMCLLIFSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC--SYLYVR--PVISF 260
Cdd:cd15952 169 rINIIYGLFAI---SVLVLDVILIALSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPAlfSFLTHRfgHNIPR 245

                       250       260
                ....*....|....*....|....*....
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15952 246 YIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

22-289

6.00e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 156.12 E-value: 6.00e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLE 181
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 LACTDTHT--LGPLIAANS--GSMCLLIfsmlVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRP 256
Cdd:cd15222 163 LACSDTRVnsIYGLFVVLStmGLDSLLI----LLSYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVH 238

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22128983 257 VISFHIDKIVSVF----YTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15222 239 RFGKHASPLVHVLmanvYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

28-289

7.83e-46

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 155.97 E-value: 7.83e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTDT 187
Cdd:cd15951  89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 188 HtlgpLIAANSGSMCLLI----FSMLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC--SYLYVR--PVI 258
Cdd:cd15951 169 R----VSRAYGLSVAFLVggldVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPAlfSFLTHRfgHNV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 22128983 259 SFHIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15951 245 PPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

28-289

7.57e-45

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 153.57 E-value: 7.57e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15953   9 LMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVciflVVAAGIVGFVHGMIQTT----FIAQLPFCGPNIINHFICDLIPLLELA 183
Cdd:cd15953  89 AVLVAMAFDRYVAICNPLRYATILTNSR----IAKLGLVGLIRGVLLILplplLLSRLPFCANRIIPHTYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 184 CTDT---HTLGPLIA-ANSGSMCLLIfsmlVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC--SYLYVR- 255
Cdd:cd15953 165 CGDTtinRIYGLVVAlLVVGLDLLLI----ALSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPAlfSFLTHRf 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22128983 256 -PVISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15953 241 gQGIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

5-290

1.89e-43

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 150.31 E-value: 1.89e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   5 TEFILLGLTQDPDLQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEK 84
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  85 STISFNGCMTQLFAEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFC 164
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 165 GPNIINHFICDLIPLLELACTDThTLGPLIAANSGSMCLLIFSM-LVASYVVILRSLRN-HSAEGRRKALSTCASHVTVV 242
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDV-SINNHYGLTIGFLVLIMDSLfIVLSYIMILRVVQRlATSEARLKTFGTCVSHVCAI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22128983 243 VLFFVP--CSYLYVR--PVISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15949 241 LAFYVPiaVSSLIHRfgQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-290

1.13e-38

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 137.34 E-value: 1.13e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  29 IYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEII 108
Cdd:cd15948  11 AFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESA 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 109 LLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAgIVGFVHGMIQTTFIAQ-LPFCGPNIINHFICDLIPLLELACTDT 187
Cdd:cd15948  91 VLLAMAFDRYVAICNPLRYATILTNSVITKIGLAA-LARAVTLMTPLPFLLRrLPYCRSHVIAHCYCEHMAVVKLACGDT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 188 ---HTLGPLIAansgsMCLLIFSML--VASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC----SYLYVRPV 257
Cdd:cd15948 170 rfnNIYGIAVA-----LFIVGLDLMfiILSYVFILRAvLSLASKEEQLKAFGTCGSHICAILVFYTPVvlssTMHRFARH 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 22128983 258 ISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEVK 290
Cdd:cd15948 245 VAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

29-289

3.20e-36

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 131.14 E-value: 3.20e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  29 IYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEII 108
Cdd:cd15956  10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 109 LLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELAC---T 185
Cdd:cd15956  90 VLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACgatT 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 186 DTHTLGPLIAANSGSMCLLIFSMlvaSYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYV----RPVISF 260
Cdd:cd15956 170 VDSLYGLALALFIGGGDVLFIAY---SYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPS 246

                       250       260
                ....*....|....*....|....*....
gi 22128983 261 HIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

28-297

2.10e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 128.77 E-value: 2.10e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983    28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFICDLIPLLELACTDt 187
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   188 htlgplIAANSGSMCLLIFS-------MLVASYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVIS 259
Cdd:pfam13853 162 ------IKVNNIYGLFVVTStfgidslLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFG 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 22128983   260 FHIDKIVSVF----YTLVTPLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:pfam13853 236 HNVPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-289

1.42e-34

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 126.86 E-value: 1.42e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  29 IYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEII 108
Cdd:cd15954  10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 109 LLISMAYDRYVAICKPLHYMTIMNRHVciflVVAAGIVGFVHGMIQ----TTFIAQLPFCGPNIINHFICDLIPLLELAC 184
Cdd:cd15954  90 VLMLMALDRYVAICYPLRYATILTNPV----ITKAGLATFLRGVMLiipfPLLTKRLPYCRGNFIPHTYCDHMSVVKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 185 TDTHT---LGPLIAANSGSMCLLIFSMlvaSYVVILRS-LRNHSAEGRRKALSTCASHVTVVVLFFVPC-----SYLYVR 255
Cdd:cd15954 166 ANIRVdaiYGLMVALLIGGFDILCISV---SYAMILRAvVSLSSKEARSKAFSTCTAHICAIVITYTPAfftffAHRFGG 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22128983 256 PVISFHIDKIVSVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15954 243 HHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

28-289

1.23e-28

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 111.01 E-value: 1.23e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15955   9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFES 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVV-----AAGIVGFVHGMIQTtfiaQLPFCGPNIINHFICDLIPLLEL 182
Cdd:cd15955  89 GILLAMALDRYVAICHPLRHSSILTPQVLLGIGVlvvvrAVVLIIPCPLLIKL----RLHHFRSTVISHSYCEHMAVVKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 183 ACTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSL-RNHSAEGRRKALSTCASHVTVVVLFFVPCSYLYVRPVISFH 261
Cdd:cd15955 165 AADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHH 244

                       250       260       270
                ....*....|....*....|....*....|..
gi 22128983 262 IDKIV----SVFYTLVTPLLNPLIYTLRNEEV 289
Cdd:cd15955 245 VAPYVhillSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

36-282

8.99e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 97.37 E-value: 8.99e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983    36 GNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMI-YDLISEKSTISFNGCMTQLFAEHFFAAAEIILLISMA 114
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   115 YDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPniiNHFICDLIPLLELACTDTHTLGPLI 194
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983   195 AANSGSMCLLIFsmlvaSYVVILRSLRNHSAEG--------RRKALSTCASHVTVVVLFFVPCSYLYVRPVISF------ 260
Cdd:pfam00001 158 LGFLLPLLVILV-----CYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALdcelsr 232

                         250       260
                  ....*....|....*....|....
gi 22128983   261 HIDKIVSV--FYTLVTPLLNPLIY 282
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

22-286

1.07e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 81.18 E-value: 1.07e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNIINHFicdliplle 181
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC--------- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 laCTDTHTLGPLIAANSGSMCLLIFSMLVASYVVILRSLRNHSAEGRRKALSTCASH------------VTVVVLFFV-- 247
Cdd:cd00637 152 --WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22128983 248 -PCSYLYVRPVISFHIDKIVSVFYTLVTPL------LNPLIYTLRN 286
Cdd:cd00637 230 lPYFILLLLDVFGPDPSPLPRILYFLALLLaylnsaINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

21-293

6.61e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 61.42 E-value: 6.61e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVhgmiqttfIAQLPFcgpnIINHFICDLIPLL 180
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL--------ISLPPL----VGWRDETQPSVVD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELaCTDTHTLGPLIAANSGSMCLLIFSMLVAsYVVILRSLRNHsaegrRKALSTcashVTVVVLFFVPC------SYLYV 254
Cdd:cd14967 149 CE-CEFTPNKIYVLVSSVISFFIPLLIMIVL-YARIFRVARRE-----LKAAKT----LAIIVGAFLLCwlpffiIYLVS 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22128983 255 RPVISFHIDKIV-SVFYTL--VTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd14967 218 AFCPPDCVPPILyAVFFWLgyLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

27-291

1.21e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 54.90 E-value: 1.21e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  27 LIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAE 106
Cdd:cd14969   8 SLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 107 IILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAagivgfvhgMIQTTFIAQLPFCGpniINHFIcdliplLELACT- 185
Cdd:cd14969  88 ISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFI---------WLYGLFWALPPLFG---WSSYV------PEGGGTs 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 186 ---DTHTLGPliAANSGSMCLLIFSML------VASYVVILRSLRNHSAEGRRKALSTCAS-----------HVTVVVLF 245
Cdd:cd14969 150 csvDWYSKDP--NSLSYIVSLFVFCFFlplaiiIFCYYKIYRTLRKMSKRAARRKNSAITKrtkkaekkvakMVLVMIVA 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128983 246 FVPC--SYLYVRPVISFHIDKIVSVFYTLVTPLL-------NPLIYTLRNEEVKR 291
Cdd:cd14969 228 FLIAwtPYAVVSLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRR 282

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

24-145

6.04e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 52.62 E-value: 6.04e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYS-SSITPKMIYDLiseksTISFNG----CMTQLFA 98
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYGgdllCRLVKYL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGI 145
Cdd:cd15196  80 QVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVL 126

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

24-293

1.11e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 51.91 E-value: 1.11e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLIS--EKSTISFNGCMTQLFAEhF 101
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVslTPSPATWLLRKGSLVLS-L 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 102 FAAAEIILLIsmAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVhgmiqttfIAQLPFCGPNIINHFICDLIPlle 181
Cdd:cd14972  82 LASAYSLLAI--AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL--------LALLPVLGWNCVLCDQESCSP--- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 182 lactdthtLGPLIAANSGSMCLLIFSMLVAS----YVVILRSLRNHSAEGRRKALSTCASH--------VTVVVLFFV-- 247
Cdd:cd14972 149 --------LGPGLPKSYLVLILVFFFIALVIivflYVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIVLGVfl 220

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128983 248 ----PCSYLYVRPVISFHIDKIVSVFY-----TLVTPLLNPLIYTLRNEEVKRVM 293
Cdd:cd14972 221 vcwlPLLILLVLDVLCPSVCDIQAVFYyflvlALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

21-290

2.18e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 50.96 E-value: 2.18e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVhgmiqttfIAQLPFCGPNIINHFICDLIPLL 180
Cdd:cd15063  82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV--------ICFPPLVGWNDGKDGIMDYSGSS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELA--CTDTHTLGPLIAANSGSMCLLIFSMLVAsYVVILRSLRNHSaegrrKALSTCASHVTVVVLFFVPCSYLY-VRPV 257
Cdd:cd15063 154 SLPctCELTNGRGYVIYSALGSFYIPMLVMLFF-YFRIYRAARMET-----KAAKTVAIIVGCFIFCWLPFFTVYlVRAF 227

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22128983 258 ISFHIDKIV-SVFYTL--VTPLLNPLIYTLRNEEVK 290
Cdd:cd15063 228 CEDCIPPLLfSVFFWLgyCNSALNPCIYALFSRDFR 263

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

21-149

2.54e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 51.20 E-value: 2.54e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLiTLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSI-TPKMIYDLISEkSTISFNGCMTQLFAE 99
Cdd:cd15065   2 IGIFLSLIIVL-AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVmTFAVVNDLLGY-WLFGETFCNIWISFD 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFV 149
Cdd:cd15065  80 VMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

21-146

1.00e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 49.37 E-value: 1.00e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPkmiYDLISEKSTISFNG---CMTQLF 97
Cdd:cd15317   2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHTG 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22128983  98 AEHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIV 146
Cdd:cd15317  79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

21-291

2.41e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 48.08 E-value: 2.41e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIylITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITP-KMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15052   4 ALLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGF-------VHGMIQTTFIAQLPFCGPNIINHF 172
Cdd:cd15052  82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIgisspipVLGIIDTTNVLNNGTCVLFNPNFV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 173 IcdlipllelactdthtlgpliaanSGSMC--LLIFSMLVASYVVILRSLRNhsaegRRKALSTCASHVTVVVLFFVPCS 250
Cdd:cd15052 162 I------------------------YGSIVafFIPLLIMVVTYALTIRLLSN-----EQKASKVLGIVFAVFVICWCPFF 212

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22128983 251 YLYVRPVISFH-----IDKIVSVFYTL--VTPLLNPLIYTLRNEEVKR 291
Cdd:cd15052 213 ITNILTGLCEEcncriSPWLLSVFVWLgyVSSTINPIIYTIFNKTFRR 260

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

24-150

3.37e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 47.63 E-value: 3.37e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLiSVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQL-----FA 98
Cdd:cd14978   5 YVLPVICIFGIIGNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPL 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVH 150
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLL 135

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

22-145

1.47e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 45.62 E-value: 1.47e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPkmiYDLISEKSTISFNG---CMTQLFA 98
Cdd:cd15318   3 IYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP---FSTIRSVESCWYFGdsfCRLHTCL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMN-RHVCIFLVVAAGI 145
Cdd:cd15318  80 DTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTiRVACIFIAAGWLV 127

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

20-142

1.61e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 45.79 E-value: 1.61e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVA 142
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAV 123

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

21-154

1.69e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 45.52 E-value: 1.69e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRH-----VCIFLVVAAgIVGFVHGMIQ 154
Cdd:cd15058  82 LCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRrarviVCVVWIVSA-LVSFVPIMNQ 139

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

21-247

1.87e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 45.36 E-value: 1.87e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLiSEKSTISFNGCMTQL--FA 98
Cdd:cd14997   2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVET-WAREPWLLGEFMCKLvpFV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHG--MIQTTFIAQLPFCGPniinhficDL 176
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSspVLFITEFKEEDFNDG--------TP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 177 IPLLELACTDTHTLGPLIAANSgSMCLLIFSMLVASYVVILRSLRNHSA--EGRRKALSTCASH---------VTVVVLF 245
Cdd:cd14997 153 VAVCRTPADTFWKVAYILSTIV-VFFVVPLAILSGLYSVICRRLVGHPAleSRRADAANRHTLRsrrqvvymlITVVVLF 231


                ..
gi 22128983 246 FV 247
Cdd:cd14997 232 FV 233

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

27-152

3.69e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 44.54 E-value: 3.69e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  27 LIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIydLISEKSTISFNGCMTQLFAEHFFAAAE 106
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--TISLGFCTDFHSCLFLACFVLVLTQSS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22128983 107 IILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGM 152
Cdd:cd15069  86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGL 131

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

24-297

7.67e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 43.40 E-value: 7.67e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFA 103
Cdd:cd15307   5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 104 AAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFV------------HGMIQTTFIAQLPFCGPNIINH 171
Cdd:cd15307  85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAmslplslmyskdHASVLVNGTCQIPDPVYKLVGS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 172 FICDLIPLLelactdthtlgpliaansgsmcllifsMLVASYVVILRSL-RNHSAEGRRKALSTCASHVTVVVLF----- 245
Cdd:cd15307 165 IVCFYIPLG---------------------------VMLLTYCLTVRLLaRQRSRHGRIIRLEQKATKVLGVVFFtfvil 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22128983 246 FVPCSYLYVRPVISFHID-KIVSVFYTLVT------PLLNPLIYTLRNEEVKRVMKKLL 297
Cdd:cd15307 218 WSPFFVLNLLPTVCAECEeRISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKVL 276

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

23-129

8.21e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 43.57 E-value: 8.21e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  23 FIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYS-SSITPKMIYDLISEKSTISFnGCMTQLFAEHF 101
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEWRAGDF-ACKVIRYLQVV 82

                        90       100
                ....*....|....*....|....*...
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHYMT 129
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNFSQ 110

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

24-291

1.03e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 42.90 E-value: 1.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPAL-ATPMYFFLSYLSIIDgFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFF 102
Cdd:cd15341   5 VLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALAD-FLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 103 AAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCiflVVAAGIVgfvhgMIQTTFIAQLPFCGPNIINhficdliplLEL 182
Cdd:cd15341  84 FTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRA---LVALAVM-----WVLTALIAYLPLMGWNCCP---------LNS 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 183 ACTDthtLGPLIAAN--SGSMCLL--IFSMLVASYVVILRSLRNHSA--------EGRRKA--------LSTCASHVTVV 242
Cdd:cd15341 147 PCSE---LFPLIPNDylLSWLLLVaiLLSGIIYTYGHVLWKAHKHVVymekhqdqQGPGNArmrldvrlAKTLGLVLAVL 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128983 243 VLFFVPCSYLYVRPVISFHIDKIVSVF-----YTLVTPLLNPLIYTLRNEEVKR 291
Cdd:cd15341 224 LICWSPVLALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRS 277

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

22-141

1.10e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 43.11 E-value: 1.10e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPkmiYDLISEKSTISFNG---CMTQLFA 98
Cdd:cd15312   3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMP---YSMVRSVESCWYFGdlfCKIHSSL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPLHY-MTIMNRHVCIFLVV 141
Cdd:cd15312  80 DMMLSTTSIFHLCFIAVDRYYAVCDPLHYrTKITTPVIKVFLVI 123

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

25-142

1.45e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 42.78 E-value: 1.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  25 VCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAA 104
Cdd:cd15336   6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22128983 105 AEIILLISMAYDRYVAICKPLHYMTIMN-RHVCIFLVVA 142
Cdd:cd15336  86 TSMITLLAISLDRYLVITKPLASIRWVSkKRAMIIILLV 124

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

24-127

1.49e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 42.61 E-value: 1.49e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITP-KMIYDLISEKSTISFNGCMTQLFAEHFF 102
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLF 84

                        90       100
                ....*....|....*....|....*
gi 22128983 103 AAAEIILLISMAYDRYVAICKPLHY 127
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHH 109

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

24-125

1.57e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 42.50 E-value: 1.57e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLiTLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSS-SITPKMIYDLiseksTISFNG----CMTQLFA 98
Cdd:cd15387   6 VLALILFL-ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGpdflCRLVKYL 79

                        90       100
                ....*....|....*....|....*..
gi 22128983  99 EHFFAAAEIILLISMAYDRYVAICKPL 125
Cdd:cd15387  80 QVVGMFASTYMLLLMSIDRCLAICQPL 106

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

21-141

2.31e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 42.16 E-value: 2.31e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPkmiYDLISEKSTISFNG---CMTQLF 97
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP---FSMIRSIETCWYFGdtfCKLHSS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22128983  98 AEHFFAAAEIILLISMAYDRYVAICKPLHYMT-IMNRHVCIFLVV 141
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLLYPTkITIRRVKICICL 123

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

21-149

2.47e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 41.73 E-value: 2.47e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15301   2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFV 149
Cdd:cd15301  82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLL 130

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

28-145

2.99e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 41.82 E-value: 2.99e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRH-----VCIFLVVAAGI 145
Cdd:cd15959  89 ETLCAIAVDRYLAITNPLRYEALVTKRrartaVCLVWAISAAI 131

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

21-284

3.08e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 41.57 E-value: 3.08e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFN-GCMTQLFAE 99
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDgGCKLYYFLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRH--------VCIFLVVAAGIVGFVHGMIQTTFIAQLPFCGPNiinh 171
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRrvkrfilaIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSA---- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 172 fICDLIPllelactDTHTLGPLIAANSGSMCLLIFSMLVASYVVI---LRSLRNHSAEGRRKALSTCASH---------- 238
Cdd:cd14979 158 -VCTLVV-------DRSTFKYVFQVSTFIFFVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSlsqqarrqvv 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22128983 239 ---VTVVVLFFVPCSYLYVRPVISFHIDK---IVSVFYTLVTPL----------LNPLIYTL 284
Cdd:cd14979 230 kmlGAVVIAFFVCWLPFHAQRLMFSYASKedtFLFDFYQYLYPIsgilfylssaINPILYNL 291

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

20-291

3.73e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 41.30 E-value: 3.73e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMiydLISEKSTISFNgcMTQLFAE 99
Cdd:cd15102   1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANI---LLSGARTLRLS--PAQWFLR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 H---FFA-AAEIILLISMAYDRYVAICKPLHYmTIMNRHVCIFLVVAAGIVGFVHGMiqttfiaqLPFCGPNIINHFicd 175
Cdd:cd15102  76 EgsmFVAlSASVFSLLAIAIERHLTMAKMKPY-GASKTSRVLLLIGACWLISLLLGG--------LPILGWNCLGAL--- 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 176 lipllelacTDTHTLGPLIAANSGSMCLLIFSMLVAS--------YVVILRSLRNHSAEGRRKALSTCASHVTVVVLFFV 247
Cdd:cd15102 144 ---------DACSTVLPLYSKHYVLFCVTIFAGILAAivalyariYCLVRASGRKATRASASPRSLALLKTVLIVLLVFI 214

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128983 248 PC-----SYL---YVRPVISFHIDKIVSVFYTLVT--PLLNPLIYTLRNEEVKR 291
Cdd:cd15102 215 ACwgplfILLlldVACPVKTCPILYKADWFLALAVlnSALNPIIYTLRSRELRR 268

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

28-143

3.99e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 41.29 E-value: 3.99e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTI-SFNGCMTQLFAEHFFAAAE 106
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHS 88

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 22128983 107 IILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAA 143
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMA 125

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

23-153

4.60e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 41.09 E-value: 4.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  23 FIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIydLISEKSTISFNGCmtqLFAEHF- 101
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGC---LFMACLv 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22128983 102 --FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMI 153
Cdd:cd14968  79 lvLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLT 132

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

21-291

4.94e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 41.15 E-value: 4.94e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSItPKMIYDLISEKSTI-SFNGCMTQLFAE 99
Cdd:cd15168   2 FLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSL-PFLIYYYANGDHWIfGDFMCKLVRFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMiqttfiAQLPFCGPNIINHFIcdlipl 179
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLL------PILFFATTGRKNNRT------ 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 180 lelACTDTHTLGPLIAANSGSMCLLI------FSMLVASYVVILRSL-----RNHSAEGRRKALSTCASHVTVVVLFFVP 248
Cdd:cd15168 149 ---TCYDTTSPEELNDYVIYSMVLTGlgfllpLLIILACYGLIVRALirklgEGVTSALRRKSIRLVIIVLALFAVCFLP 225

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22128983 249 -----CSYLYVR---PVISFHIDKIVSVFYTLVTPL------LNPLIYTLRNEEVKR 291
Cdd:cd15168 226 fhvtrTINLAARllsGTASCATLNGIYVAYKVTRPLaslnscLNPLLYFLAGDKFRR 282

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

21-127

7.09e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 40.24 E-value: 7.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15324   2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81

                        90       100
                ....*....|....*....|....*..
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHY 127
Cdd:cd15324  82 LFCTSSIVHLCAISLDRYWSVTKAVSY 108

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

28-293

7.22e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 40.49 E-value: 7.22e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFAAAEI 107
Cdd:cd15073   9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 108 ILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAgivgfvhgmiqttfiaqlpfcgpniINHFICDLIPLLELACTDT 187
Cdd:cd15073  89 GLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAW-------------------------TNAFFWAAMPLVGWASYAL 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 188 HTLGPLIAAN---------SGSMCLLI------FSMLVASYVVILRSLRNHSAEGRRKALSTCASH--------VTVVVL 244
Cdd:cd15073 144 DPTGATCTINwrkndssfvSYTMSVIVvnfivpLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqndvtkmsVIMIVM 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22128983 245 FFVPCS-YLYVRPVISFHIDKIVSVFYTLVTPLL-------NPLIYTLRNEEVKRVM 293
Cdd:cd15073 224 FLVAWSpYSIVCLWASFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

21-149

7.43e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 40.30 E-value: 7.43e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITP-KMIYdlisekstiSFNGCMtqLFAE 99
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPpSMVR---------SVETCW--YFGD 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22128983 100 HF----------FAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVA----AGIVGFV 149
Cdd:cd15314  71 LFckihssfditLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILIswsvSALVGFG 134

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

21-127

1.21e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 39.56 E-value: 1.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                        90       100
                ....*....|....*....|....*..
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHY 127
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVITRPLTY 108

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

20-125

1.38e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 39.80 E-value: 1.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  20 KLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIID---GFYSssITPKMIYDLiseksTISFNG----C 92
Cdd:cd15385   1 KLEIAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADlvvAFFQ--VLPQLCWDI-----TYRFYGpdflC 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 22128983  93 MTQLFAEHFFAAAEIILLISMAYDRYVAICKPL 125
Cdd:cd15385  74 RIVKHLQVLGMFASTYMLVMMTADRYIAICHPL 106

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

24-125

1.55e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 39.67 E-value: 1.55e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  24 IVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYS-SSITPKMIYDLISEKSTISFnGCMTQLFAEHFF 102
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGDV-LCRIVKYLQVVG 83

                        90       100
                ....*....|....*....|...
gi 22128983 103 AAAEIILLISMAYDRYVAICKPL 125
Cdd:cd14986  84 LFASTYILVSMSLDRYQAIVKPM 106

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

18-127

2.06e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 39.01 E-value: 2.06e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  18 LQKLLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLF 97
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82

                        90       100       110
                ....*....|....*....|....*....|
gi 22128983  98 AEHFFAAAEIILLISMAYDRYVAICKPLHY 127
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEY 112

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

21-291

2.49e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 38.88 E-value: 2.49e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFvhgmiqttFIAQLPFCGPNiiNHFicdliPLL 180
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVGPS--WHG-----RRG 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 181 ELACTDTHTLGPLIAAnsgSMCLLIFSMLVASYVViLRSLRnhSAEGRRKALSTcashVTVVVLFFVPC------SYLyV 254
Cdd:cd15061 146 LGSCYYTYDKGYRIYS---SMGSFFLPLLLMLFVY-LRIFR--VIAKERKTAKT----LAIVVGCFIVCwlpffiMYL-I 214

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22128983 255 RPVISFHIDKIVSVFYTLV---TPLLNPLIYTLRNEEVKR 291
Cdd:cd15061 215 EPFCDCQFSEALSTAFTWLgyfNSVINPFIYAFYNKDFRR 254

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

37-293

2.50e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 38.76 E-value: 2.50e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  37 NMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFngcMTQLFAEHFFAAAeIILLISMAYD 116
Cdd:cd15962  18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL---ITVGFLVASFTAS-VSSLLAITVD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 117 RYVAICKPLHYMTimnrhvciflvvaAGIVGFVHGMIQTTFIAQLpFCGpniinhficdLIPLLELACTDTHT----LGP 192
Cdd:cd15962  94 RYLSLYNALTYYS-------------EKTVLGVHLMLAATWGVSL-CLG----------LLPVLGWNCLEERAscsiVRP 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 193 LIAANSGSMC---LLIFSMLVASYVVILRSLRNHSAE--------------GRRKALSTCAshvtvVVLFFVPCSYL--Y 253
Cdd:cd15962 150 LTKSNVTLLSasfFFIFILMLHLYIKICKIVCRHAHQialqqhfltashyvATKKGVSTLA-----IILGTFGASWLpfA 224

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22128983 254 VRPVISFHIDKIVSVFYTLV----TPLLNPLIYTLRNEEVKRVM 293
Cdd:cd15962 225 IYCVVGDHEYPAVYTYATLLpatyNSMINPIIYAYRNQEIQRSM 268

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

21-125

3.69e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 38.33 E-value: 3.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNmliSVTIFI---SPALATPMYFFLSYLSIIDgFYSSSITPKMIYDLISEKSTISFNGCMTQLF 97
Cdd:cd15079   2 LLGFIYIFLGIVSLLGN---GLVIYIfstTKSLRTPSNMLVVNLAISD-FLMMIKMPIFIYNSFYEGWALGPLGCQIYAF 77

                        90       100
                ....*....|....*....|....*...
gi 22128983  98 AEHFFAAAEIILLISMAYDRYVAICKPL 125
Cdd:cd15079  78 LGSLSGIGSIWTNAAIAYDRYNVIVKPL 105

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

21-125

3.89e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 38.22 E-value: 3.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15205   2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQS 81

                        90       100
                ....*....|....*....|....*
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPL 125
Cdd:cd15205  82 TAVVTSILTMTCIAVERHQGIVHPL 106

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

28-140

4.38e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 38.39 E-value: 4.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  28 IIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKS-TISFNGCMTQLFAEHFFAAAE 106
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHA 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 22128983 107 IILLISMAYDRYVAICKPLHYMTIMNRHVCIFLV 140
Cdd:cd15217  89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVI 122

7tmA_P2Y6_P2Y3-like

cd15968

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...

21-291

5.21e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320634 [Multi-domain] Cd Length: 285 Bit Score: 37.83 E-value: 5.21e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSItPKMIYDLISEKSTISFN-GCMTQLFAE 99
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSL-PLLIYNYAMRDRWLFGDfMCRLVRFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHgMIQTTFIAQLPFcgpnIINHFIC-DLIP 178
Cdd:cd15968  81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQ-TLPILIFARTGI----IRNRTVCyDLAP 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 179 LLELacTDTHTLGPLIAAnsgSMCLLIFSMLVASYVVILRSLRNH-------SAEGRRKALSTCashVTVVVLF---FVP 248
Cdd:cd15968 156 PALF--PHYVPYGMALTV---SGFLLPFSIILWCYCLVVRTLCRTlgpaeppAQARRRKSIRTI---VTVTLLFalcFLP 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22128983 249 -----CSYLYVR--PVISFHIDKIVSVFYTLVTPL------LNPLIYTLRNEEVKR 291
Cdd:cd15968 228 fhitrTIYLAVRvtPGVPCHVLEAVAACYKITRPLasansvLNPLLYFLTKKKFGR 283

7tmA_GPR17

cd15161

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...

21-248

6.23e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.

Pssm-ID: 320289 [Multi-domain] Cd Length: 277 Bit Score: 37.77 E-value: 6.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVC-LIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAE 99
Cdd:cd15161   1 ILFALFyILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTI---MNRHV-CIFL----VVAAGIVGFVHGMIQTTfiaqlpfcgpniiNH 171
Cdd:cd15161  81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIrkpLYAHVvCGFLwvivTVAMAPLLVSPQTVEVN-------------NT 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 172 FICDLiplLELACTDTHTLGPLIAAnsgsmCLLIFSMLVASYVVILRSLRNHSAEGR---RKALSTCASHVTVVVLFFVP 248
Cdd:cd15161 148 TVCLQ---LYREKASRGALVSLAVA-----FTIPFVTTVTCYLLIIRSLRTGKREEKplkDKAIKMIILVLTIFLICFVP 219

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

21-180

6.40e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 37.61 E-value: 6.40e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIydLISEKSTISFNGCMTQLFAEH 100
Cdd:cd15068   2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983 101 FFAAAEIILLISMAYDRYVAICKPLHYMTIMNRH-------VCIFLVVAAGI---VGFVHGMIQTTFIAQLPFCGPNII- 169
Cdd:cd15068  80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTrakgiiaICWVLSFAIGLtpmLGWNNCGQPKEGKNHSQGCGEGQVa 159

                       170       180
                ....*....|....*....|....*.
gi 22128983 170 ---------------NHFICDLIPLL 180
Cdd:cd15068 160 clfedvvpmnymvyfNFFACVLVPLL 185

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

21-149

7.20e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 37.32 E-value: 7.20e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITP-KMIYDLISEKSTISFnGCMTQLFAE 99
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPfSLVNELMGYWYFGSV-WCEIWLALD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFV 149
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAV 130

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

22-127

7.30e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 37.23 E-value: 7.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  22 LFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHF 101
Cdd:cd15322   3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82

                        90       100
                ....*....|....*....|....*.
gi 22128983 102 FAAAEIILLISMAYDRYVAICKPLHY 127
Cdd:cd15322  83 FCTSSIVHLCAISLDRYWSITQAIEY 108

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

21-148

7.71e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 37.12 E-value: 7.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIY-DLISEKSTISFNGCMTQLFAE 99
Cdd:cd15308   2 AALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYsEFQGGVWTLSPVLCDALMTMD 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGF 148
Cdd:cd15308  82 VMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSF 130

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

27-142

8.09e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 37.19 E-value: 8.09e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  27 LIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITP-KMIYDLISEKSTISFNGCMTQLFAEHFFAAA 105
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLFSTA 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 22128983 106 EIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVA 142
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAA 124

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

21-149

8.39e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 37.25 E-value: 8.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  21 LLFIVCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYS-SSITPKMIYDLISEKStISFNGCMTQLFAE 99
Cdd:cd15297   2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGvFSMNLYTLYTVIGYWP-LGPVVCDLWLALD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22128983 100 HFFAAAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFV 149
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFI 130

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-131

8.53e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 37.08 E-value: 8.53e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  25 VCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFA- 103
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIDNVIDSm 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 22128983 104 -----AAEIILLISMAYDRYVAICKPLHYMTIM 131
Cdd:cd15103  86 icsslLASICSLLAIAVDRYITIFYALRYHSIM 118

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

25-153

9.29e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 37.18 E-value: 9.29e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22128983  25 VCLIIYLITLAGNMLISVTIFISPALATPMYFFLSYLSIIDGFYSSSITPKMIYDLISEKSTISFNGCMTQLFAEHFFA- 103
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSm 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22128983 104 -----AAEIILLISMAYDRYVAICKPLHYMTIMNRHVCIFLVVAAGIVGFVHGMI 153
Cdd:cd15352  86 icislVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIV 140

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01